摘要
目的观察加味薏苡附子败酱散治疗复杂性肛瘘(正虚邪恋证)疗效,并探讨其对患者创面新血管生成、炎性因子及创伤应激水平的影响。方法随机将石家庄中医院2019年2月—2020年3月收治的90例肛瘘(正虚邪恋证)住院患者分为观察组和对照组。所有患者均行肛瘘切开挂线术治疗,术后切口不予缝合;对照组45例给予重组牛碱性成纤维细胞生长因子外用治疗,观察组45例给予加味薏苡附子败酱散外用治疗,疗程均为3周。比较两组术后1周、3周创面新血管生成情况,干预前后中医证候积分、炎性因子、创伤应激相关指标,创面愈合时间和临床疗效等。结果观察组术后1周、3周创面肉芽颜色积分均低于对照组,创面新生毛细血管数和愈合率均高于对照组(P<0.05);干预后,两组中医证候积分均有明显降低,且观察组低于对照组(P<0.05);干预后,两组白细胞介素-2(IL-2)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平均有明显降低,且观察组低于对照组(P<0.05);干预后,两组晚期氧化蛋白产物(AOPP)、8-羟基脱氧鸟苷(8-OHDG)和皮质醇水平均有明显降低,且观察组低于对照组(P<0.05);观察组创面愈合时间低于对照组(P<0.05);两组临床治疗总有效率比较差异无统计学意义(P>0.05),但疗效分布差异具有统计学意义,观察组临床疗效优于对照组(P<0.05)。结论加味薏苡附子败酱散治疗复杂性肛瘘(正虚邪恋证)疗效确切,能够促进创面新生血管生成,改善炎症反应和创伤应激指标,从而加速创面愈合。
Objective To observe the curative effect of Modified Yiyi Fuzi Baijiang Powder(加味薏苡附子败酱散)in the treatment of complex anal fistula(syndrome of lingering pathogen due to deficient vital Qi),and to explore its influence on neovascularization,inflammatory factors and traumatic stress level of patients.Methods From February 2019 to March 2020,90 patients with anal fistula(syndrome of lingering pathogen due to deficient vital Qi)were randomly divided into observation group and control group.All patients were treated with fistula incision and thread drawing,and the incision was not sutured;the control group(45 cases)was given recombinant bovine basic fibroblast growth factor(rbb FGF)for external use,and the observation group(45 cases)was given Modified Yiyi Fuzi Baijiang Powder for external use,and the course of treatment was 3 weeks.The neovascularization,TCM syndrome score,inflammatory factors,wound stress related indicators,wound healing time and clinical efficacy were compared between the two groups 1 week and 3 weeks after operation.Results The score of granulation color in the observation group was lower than that in the control group at 1 week and 3 weeks after operation,and the number of new capillaries and healing rate in the observation group were higher than those in the control group(P<0.05);After the intervention,the TCM syndrome scores of the two groups were significantly decreased,and the observation group was lower than the control group(P<0.05);After intervention,the levels of interleukin-2(IL-2),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were significantly lower than those in the control group(P<0.05);After the intervention,the levels of AOPP,8-OHDG and cortisol in the observation group were significantly lower than those in the control group(P<0.05);The wound healing time of the observation group was lower than that of the control group(P<0.05);There was no significant difference in the total effective rate between the two groups(P>0.05),but the rank sum test showed that P<0.05.The distribution of curative effect between the two groups was different.The clinical efficacy of the observation group was better than that of the control group(P<0.05).Conclusion Modified Yiyi Fuzi Baijiang Powder is effective in the treatment of complex anal fistula(syndrome of lingering pathogen due to deficient vital Qi).It can promote the angiogenesis of wound,improve the inflammatory reaction and trauma stress index,so as to accelerate the wound healing.
作者
吴剑箫
鲍虎豹
张东臣
冯奇
王瑜
WU Jianxiao;BAO Hubao;ZHANG Dongchen;FENG Qi;WANG Yu(Shijiazhuang Hospital of Traditional Chinese Medicine,Shijiazhuang 050051,Hebei,China)
出处
《辽宁中医药大学学报》
CAS
2021年第7期135-138,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
河北省中医药管理局中医药类科研计划项目(2019436)
关键词
复杂性肛瘘
加味薏苡附子败酱散
血管生成
炎性因子
创伤应激
complex anal fistula
Modified Yiyi Fuzi Baijiang Powder(加味薏苡附子败酱散)
angiogenesis
inflammatory factors
traumatic stress
