摘要
目的研究苯磺酸左旋氨氯地平治疗继发性高血压的疗效及对患者动脉硬化的影响。方法采用分层抽样法从2016年1月—2019年12月湖北省应城市人民医院收治的继发性高血压患者中抽选82例纳入本次实验,并采用随机数字表法将其中41例纳入参照组,剩余41例纳入研究组,分别实施苯磺酸氨氯地平治疗和苯磺酸左旋氨氯地平治疗,统计并比较两种治疗方式下的治疗总有效率、患者血压水平改善、动脉硬化改善情况以及不良反应情况。结果研究组治疗总有效率97.56%高于参照组的87.81%(P<0.05);治疗后2组收缩压、舒张压水平均降低,但研究组比参照组更低(P<0.05);治疗前组间动脉硬化各指标水平差异均无统计学意义(P>0.05),治疗后2组动脉硬化各指标水平均改善,但研究组治疗后水平均优于参照组(P<0.05);研究组不良反应发生率4.88%低于参照组的14.63%,(P<0.05)。结论苯磺酸左旋氨氯地平可提高对继发性高血压患者的治疗效果,利于患者血压降低和血管动脉硬化的改善,并且可降低药物不良反应发生率,是一种可以安全、有效治疗继发性高血压的方法。
Objective To study the effect of L-amlodipine besylate on secondary hypertension and its effect on patients with arteriosclerosis.Methods Stratified sampling was used to select 82 patients with secondary hypertension from January 2016 to December 2019 in the hospital for inclusion in this experiment,and 41 of them were included in the reference group using random number table method.The remaining 41 cases were included in the study group,respectively,and were treated with amlodipine besylate and levamlodipine besylate.The total treatment efficiency,blood pressure level,improvedarteriosclerosis under the two treatment methodsand adverse reactions were counted and compared.Results The total effective rate of treatment in the study group was 97.56%,whichwas higher than 87.81%in the reference group(P<0.05).After treatment,the systolic and diastolic blood pressures of the two groups decreased,but the study group was lower than those in the reference group(P<0.05).There was no significant difference in the levels of arteriosclerosis between the groups before treatment(P>0.05).After treatment,the levels of the arteriosclerosis indicators improved in both groups,but the study group was better than the reference group after treatment(P<0.05).The incidence of adverse reactions in the group was 4.88%,which was lower than 14.63%in the reference group(P<0.05).Conclusion L-amlodipine besylate can improve the therapeutic effect on patients with secondary hypertension,which is beneficial to the reduction of blood pressure and vascular arteriosclerosis,and can reduce the incidence of adverse drug reactions.It is a safe and effective treatment for secondary method of essential hypertension.
作者
张礼丙
ZHANG Libing(Department of Cardiology,Hubei Yingcheng People's Hospital,Yingcheng 432400,China)
出处
《实用心脑肺血管病杂志》
2020年第S01期88-90,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
苯磺酸左旋氨氯地平
继发性高血压
血压水平
动脉硬化
不良反应
L-amlodipine besylate
Secondary hypertension
Blood pressure level
Arteriosclerosis
Adverse reactions
