摘要
目的探讨鼻咽癌患者外周血中性粒细胞与淋巴细胞比值(NLR)检测的价值。方法回顾性分析255例鼻咽癌患者的临床资料,对患者的基本资料、白细胞计数、淋巴细胞计数以及NLR进行记录,比较未复发组与复发组的各项指标水平。结果255例鼻咽癌患者中123例患者复发,132例患者未复发,两组性别、年龄差异无统计学意义(P>0.05);复发组患者的中性粒细胞水平高于未复发组,淋巴细胞水平低于未复发组,差异具有统计学意义(P<0.05);复发组患者的NLR高于未复发组,差异具有统计学意义(P<0.05);NLR诊断鼻咽癌复发的灵敏度与特异度均高于中性粒细胞与淋巴细胞,差异具有统计学意义(P<0.05);通过绘制ROC曲线,当NLR<3.69时未复发率明显高于复发率,当NLR≥3.69时未复发率明显低于复发率,差异均具有统计学意义(P<0.05)。结论鼻咽癌预后复发评估中NLR可发挥一定价值,可能成为临床上对鼻咽癌患者预后进行评估的方便指标。
Objective To explore the value of neutrophil-lymphocyte ratio(NLR)detection in peripheral blood of patients with nasopharyngeal carcinoma.Methods The clinical data of 255 patients with nasopharyngeal carcinoma were retrospectively analyzed.The basic data,white blood cell count,lymphocyte count,and NLR of the patients were recorded,and the levels of various indicators in the non-relapsed group and the relapsed group were compared.Results Among the 255 patients with nasopharyngeal carcinoma,123 patients relapsed,and 132 patients did not relapse.There was no significant difference in gender and age between the two groups(P>0.05).The neutrophil levels were higher in the relapse group than in the non-relapse group.The lymphocyte level was lower than that of the non-relapsed group,and the difference was statistically significant(P<0.05).The NLR in the relapsed group was higher than that of the non-relapsed group,and the difference was statistically significant(P<0.05).The sensitivity and specificity were higher than that of neutrophils and lymphocytes,and the difference was statistically significant(P<0.05).By plotting the ROC curve,the non-relapse rate was significantly higher than the recurrence rate when NLR<3.69,and when NLR≥3.69 The non-recurrence rate was significantly lower than the recurrence rate,and the differences were statistically significant(P<0.05).Conclusion NLR can play a certain role in the evaluation of prognosis and recurrence of nasopharyngeal carcinoma,and it may be a convenient index for evaluating the prognosis of patients with nasopharyngeal carcinoma.
作者
赵以谦
练键勤
罗春林
ZHAO Yiqian;LIAN Jianqin;LUO Chunlin(Department of Otolaryngology,Hui Ya Hospital of The First Affiliated Hospital,Sun Yat-sen University,Huizhou,Guangdong 516000,China)
出处
《新疆医学》
2020年第7期681-684,共4页
Xinjiang Medical Journal
基金
惠州市科技计划项目(项目编号:2019Y370)
关键词
鼻咽癌
外周血
中性粒细胞/淋巴细胞
预后
Nasopharyngeal Carcinoma
Peripheral Blood
Neutrophil/Lymphocyte
Prognosis
