甘精胰岛素注射液联合阿卡波糖片对磺脲类继发性失效的2型糖尿病疗效、血糖指标及安全性研究被引量：10

Study on the efficacy, blood glucose index and safety of insulin glargine injection combined with acarbose tablet in the treatment of type 2 diabetes mellitus with secondary failure of sulfonylurea

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摘要目的磺脲类继发失效2型糖尿病应用阿卡波糖联合甘精胰岛素注射液临床疗效、血糖与安全性情况分析。方法选取本院2018年11月-2019年11月诊治110例磺脲类继发失效2型糖尿病患者资料,随机分为两组,对照组予阿卡波糖,研究组予以阿卡波糖联合甘精胰岛素注射液,分析两组疗效、血糖指标与安全性情况。结果治疗后,研究组24 h血糖的达标(11.86±2.36)h比对照组低;研究组SDS(抑郁自评量表)(37.21±1.52)、SAS(焦虑自评量表)(36.69±2.67)分等心理指标比对照组低,比较具统计意义(P<0.05);研究组糖化血红蛋白(6.71±0.73)%、空腹血糖(6.89±0.59)mmol/L和餐后2h血糖(11.85±1.25)mmol/L,均比对照组低,差异具统计意义(P<0.05);研究组发生心悸、头晕等不良反应5.45%比对照组18.18%少,差异具统计意义(P<0.05)。结论磺脲类继发失效2型糖尿病应用阿卡波糖联合甘精胰岛素注射液治疗,能有效改善患者心理指标,减少血糖的达标时间,降低其血糖水平,具临床用药的安全性。 Objective To analyze the clinical efficacy,blood glucose and safety of acarbose combined with insulin glargine injection in type 2 diabetes mellitus with secondary failure of sulfonylurea.Methods From November 2018 to November 2019,110 patients with secondary failure of sulfonylurea type 2 diabetes were randomly divided into two groups:the control group was given acarbose,the study group was given acarbose combined with insulin glargine injection,and the efficacy,blood glucose index and safety of the two groups were analyzed.Results After treatment,the blood glucose level in the study group was 11.86±2.36 h lower than that of the control group.The scores of SDS(37.21±1.52)and SAS(36.69±2.67)in the study group were lower than that of the control group,with statistical significance(P<0.05).Hba1 c(6.71±0.73)%,fasting glucose(6.89±0.59)mmol/L and postprandial 2 h glucose(11.85±1.25)mmol/L were all lower in the study group than of the control group,with statistically significant differences(P<0.05).Adverse reactions such as palpitations and dizziness were less in the study group(5.45%)than of the control group(18.18%),and the difference was statistically significant(P<0.05).Conclusion The application of acarbose combined with insulin glargine injection in the treatment of secondary failure type 2 diabetes with sulfonylureas can effectively improve the psychological indicators of patients,reduce the time of blood glucose reaching the standard,and reduce their blood glucose level,which is safe for clinical use.

作者杨丽斌 YANG Libin(Urumqi Friendship Hospital,Urumqi,830049,China)

机构地区乌鲁木齐市友谊医院

出处《新疆医学》 2020年第7期685-687,共3页 Xinjiang Medical Journal

关键词磺脲类继发失效2型糖尿病阿卡波糖甘精胰岛素疗效血糖安全性 Secondary Failure of Sulfonylurea Type 2 Diabetes Acarbose Insulin Glargine Curative Effect Blood Sugar Security

分类号 R587.1 [医药卫生—内分泌]