摘要
目的应用胃食管反流病量表(gastroesophageal reflux disease questionnaire,Gerd Q)分析肺癌患者化疗后胃食管反流病患病情况,并分析其相关影响因素。方法采用横断面调查法,应用Gerd Q量表对泰兴市人民医院2017年10月~2018年10月间肿瘤科住院接受化疗的163例肺癌患者进行问卷调查,分析肺癌患者化疗后胃食管反流病的患病情况及其相关影响因素。结果患者胃食管反流病发生81例,未发生82例,患病率49.69%;单因素分析肺癌患者化疗后胃食管反流病发病影响因素包括:年龄、文化程度、肺癌病理分型、肿瘤TNM分期、化疗次数及化疗方案。二元Logistic回归分析发生胃食管反流病危险因素由大到小分别为化疗次数、肿瘤TNM分期、年龄、化疗方案(OR值6.566、3.231、1.666、0.163),保护因素为文化程度(OR=0.611)。结论Gerd Q量表可用于肺癌患者化疗后胃食管反流病初步诊断,肺癌患者应用吉西他滨+铂类方案化疗方案最易引发胃食管反流病。对年龄大于65岁、化疗次数大于4次、肿瘤TNM分期大于Ⅲ期、文化程度初中以下的肺癌化疗患者应提早干预,预防胃食管反流病的发生或减轻患者化疗后胃食管反流症状,减轻患者痛苦,提高治疗效果及生存质量。
Objective To apply the gastroesophageal reflux disease questionnaire(Gerd Q)to analyze the prevalence of gastroesophageal reflux disease in patients with lung cancer after chemotherapy,and analyze its related influencing factors.Methods Using the cross-sectional survey method,the Gerd Q scale was used to conduct a questionnaire survey on 163 patients with lung cancer who received chemotherapy in the oncology department of Taixing People’s Hospital from October 2017 to October 2018,and analyzed the prevalence and related influencing factors of gastroesophageal reflux disease in patients with lung cancer after chemotherapy.Results 81 cases of gastroesophageal reflux disease occurred in patients,82 cases did not occur,the prevalence rate was 49.69%;Univariate analysis of factors affecting the incidence of gastroesophageal reflux disease in lung cancer patients after chemotherapy included:age,education level,lung cancer pathological type,Tumor TNM staging,number of chemotherapy and chemotherapy regimen.Binary Logistic regression analysis showed that the risk factors for gastroesophageal reflux disease in descending order were the number of chemotherapies,tumor TNM stage,age,chemotherapy regimen(OR=6.566,3.231,1.666,0.163),and the protective factor was education level(OR=0.611).Conclusion The Gerd Q scale can be used for the preliminary diagnosis of gastroesophageal reflux disease in patients with lung cancer after chemotherapy.Gastroesophageal reflux disease is most likely to be caused by the chemotherapy of gemcitabine+platinum-based regimen in patients with lung cancer.For lung cancer chemotherapy patients who are older than 65 years old,more than 4 times of chemotherapy,tumor TNM stage greater than stageⅢ,and education level below junior high school should intervene early to prevent the occurrence of gastroesophageal reflux disease or reduce the symptoms of gastroesophageal reflux after chemotherapy,alleviate the suffering of patients,improve treatment effect and quality of life.
作者
李宇
肖扬
王逢民
LI Yu;XIAO Yang;WANG Fengmin(Taixing People's Hospital,Taixing 225400,Jiangsu,China)
出处
《新疆医学》
2021年第7期771-775,765,共6页
Xinjiang Medical Journal
基金
泰州市科技支撑社会发展计划(指导性)项目(项目编号:2017-33)
关键词
Gerd
Q量表
肺癌患者
化疗
胃食管反流病
Gerd Q scale
lung cancer patient
undergoing chemotherapy
gastroesophageal
