摘要
我国金莲花属(Trollius)药用植物有16种,7个变种,具有清热、解毒、消肿等功效,用于治疗急慢性扁桃体炎、急性中耳炎、慢性支气管炎和尿路感染等疾病。通过查阅中国知网、万方数据库、百度学术和Pub Med等多个数据库中关于金莲花属植物从1972年到2019年的文献资料,整理归纳了我国金莲花属药用植物的栽培种植、质量控制方法、提取纯化工艺、化学成分、药理作用、药动和代谢等方面的内容。栽培种植研究,主要集中在种子处理和组织培养体系的建立;质量控制方面,主要以荭草苷和总黄酮为指标;提取纯化工艺研究,主要为总黄酮类成分的提取纯化;化学成分方面,目前从该属植物中分离得到的主要化合物有100多个,包括黄酮类、有机酸类、生物碱类、香豆素类和苯乙素类等,其中黄酮类单体80个,有机酸类单体12个,生物碱类单体3个,香豆素类单体4个,苯乙素类单体14个;药理作用方面,主要为药材粗提物的体外实验;药动和代谢方面的资料主要集中在黄酮单体成分的研究。
There are 16 species and 7 varieties of medicinal plants of Trollius in China,with effects in clearing heat,detoxification and swelling,they are used for the treatment of acute and chronic tonsillitis,acute otitis media,chronic bronchitis and urinary tract infections.Through retrieval of literatures on nasturtium from1972 to 2019 in a number of databases,such as CNKI,Wanfang Database,Baidu Academic and PubMed,the cultivation and quality control methods,extraction and purification processes,chemical composition,pharmacological effects,pharmacokinetics and metabolism of medicinal plants of the genus nasturtium were summarized.The researches of cultivation mainly focus on the establishment of seed treatment and tissue culture system.Quality control is mainly based on orientin and flavonoids.Research on extraction and purification technology mainly focused on the extraction and purification of total flavonoids.In terms of chemical composition,there are currently more than 100 major compounds isolated from this genus,including flavonoids,organic acids,alkaloids,coumarins and styrenes.Among them,there are 80 flavonoids,12 organic acid monomers,3 alkaloid monomers,4 coumarin monomers and 14 styrene monomers.In terms of pharmacological action,there are mainly in vitro experiments of crude extracts of medicinal materials.The data of pharmacokinetics and metabolism mainly focus on the study of flavone monomers.
作者
李洪涛
樊锐锋
赵金椽
苏连杰
LI Hong-tao;FAN Rui-feng;ZHAO Jin-chuan;SU Lian-jie(Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第7期239-250,共12页
Chinese Journal of Experimental Traditional Medical Formulae
基金
哈尔滨市应用技术研究与开发项目(2017RAXXJ082).
关键词
金莲花属
栽培
质量控制
提取纯化
化学成分
药理作用
Trollius
cultivation
quality control
extraction and purification
chemical composition
pharmacological action
