摘要
目的对胚胎停育流产物进行染色体微阵列分析,探讨流产物染色体异常与胚胎停育流产的关系。方法收集166例胚胎停育并行人工流产患者的流产物,进行染色体微阵列分析检测。结果166例标本共检出染色体异常100例,检出率60.24%;其中染色体数目异常84例(占84.00%),染色体结构异常14例(占14.00%),单亲二倍体2例(2.00%)。结论胚胎停育流产与流产物染色体异常密切相关,且染色体数目异常是导致胚胎停育流产的主要原因。
Objective:To investigate the relationship between chromosomal abnormalities and abortion by chromosomal microarray analysis on abortion tissues.Methods:The chromosomal microarray analysis was performed on 166 abortion tissues.Results:In all,chromosomal abnormalities were found in 100 cases(60.24%).Of them,the numerical chromosomal abnormalities were detected in 84(84.00%),following by 14 cases of structural chromosomal abnormalities(14.00%),and 2 cases of uniparental disomy(2.00%).Conclusions:The abortion is intimately correlated with the chromosomal abnormality of abortion tissues,and especially the numerical chromosomal abnormalities is the material cause that result in abortion.
作者
张池
胡晞江
刘翎
向萍霞
宁丽芳
余宏盛
黄会
ZHANG Chi;HU Xi-jiang;LIU Ling;XIANG Ping-xia;NING Li-fang;YU Hong-sheng;HUANG Hui(Eugenic Genetic Laboratory,Wuhan Children′s Hospital(Wuhan Maternal and Child Healthcare Hospital),Tongji Medical College,Huazhong University of Science&Technology,Wuhan 430016,China)
出处
《中国优生与遗传杂志》
2020年第7期793-794,852,共3页
Chinese Journal of Birth Health & Heredity
关键词
流产物
染色体微阵列分析
染色体数目异常
染色体结构异常
Abortion tissue
Chromosomal microarray analysis
Numerical chromosomal abnormalities
Structural chromosomal abnormalities
