摘要
目的观察妊娠晚期GBS检测与产时干预对妊娠晚期GBS阳性产妇的妊娠结局及新生儿结局的影响。方法以产时干预实施前(2018.1~12)收治的58例GBS阳性产妇作为未产时干预组,以产时干预实施后(2019.1~12)收治的58例GBS阳性产妇作为产时干预组。未产时干预组未给予任何药物干预。产时干预组给予青霉素(产前4h给予500万单位静脉滴注)的抗生素和金双歧益生菌(分娩前1w,每天6-8粒,分早晚2次服用)的微生态制剂。对比分析产时干预组和未产时干预组妊娠晚期产妇的妊娠结局、新生儿结局及新生儿脐血炎性指标的组间差异。结果孕妇妊娠结局(PRM、IBI、PD、TAF、PH、FD)发生率比较,产时干预组均低于未产时干预组(P均<0.05)。产时干预组的新生儿不良结局(NA、NS、NBIM、NJ、NP)发生率均低于未产时干预组(P均<0.05)。产时干预组的新生儿脐血炎症因子(PCT、IL-6、CRP)表达值均低于未产时干预组(P均<0.05)。结论妊娠晚期GBS检测与微生态制剂联合抗生素的产时干预在改善GBS阳性产妇妊娠结局及婴儿结局上效果显著,可避免妊娠晚期GBS阳性导致的炎性反应对妊娠结局的影响。
Objective:To observe the effect of GBS detection in the third trimester of pregnancy and prenatal intervention on pregnancy outcome and neonatal outcome of group B streptococcus(GBS)positive pregnant women.Methods:Taking the late pregnant women admitted by Benyuan from January 2018 to December 2019 as the study object,58 late pregnant women from January 2018 to December 2018 were taken as the retrospective control group,and 58 late pregnant women from January 2019 to December 2019 were taken as the intervention study group.There was no drug intervention in the retrospective control group.The intervention group was given antibiotics of penicillin for injection(5 million units intravenous drip,3 times a week from)and microecological preparation of probiotics of Bifidus aureus(6-8 capsules per day before delivery,twice in the morning and evening).to compare and analyze the difference of pregnancy outcome,neonatal outcome and inflammatory index of cord blood between the parturient intervention group and non-parturient Intervention Group.Results:The incidence of pregnancy outcome(PRM,IBI,PD,TAF,Ph,FD)in the intervention group was lower than that in the non-intervention Group(P<0.05).The incidence of neonatal adverse outcomes(NA,NS,NBIM,NJ,NP)in the intervention group was lower than that in the non-intervention Group(P<0.05).The expression of Procalcitonin,IL-6 and CRP in cord blood of the intervention group was lower than that of the non-intervention Group(P<0.05).Conclusion:The effect of GBS detection and microecological agents combined with antibiotics during labor on improving the pregnancy outcome and infant outcome of GBS positive pregnant women is significant,which can avoid the influence of inflammatory reaction caused by GBS positive in late pregnancy on pregnancy outcome.
作者
房姝妍
李涛淘
王杨
王红霞
张薇
FANG Shu-yan;LI Tao-tao;WANG Yang;WANG Hong-xia;ZHANG Wei(Obstetrics and Gynecology,Baoshihua Hospital,Liaohe Oilfield,Panjin 124010)
出处
《中国优生与遗传杂志》
2020年第7期841-843,共3页
Chinese Journal of Birth Health & Heredity
关键词
B族链球菌阳性
妊娠结局
益生菌
预防性治疗
微生态制剂
青霉素
Group B Streptococcus positive
Pregnancy outcome
Probiotics
Preventive treatment
Microecological agents
Penicillin
