摘要
目的回顾分析南京地区新生儿先天性甲状腺功能减低症筛查情况。方法选择1987年1月~2019年12月出生的1325810例新生儿,于出生48-72h充分哺乳后采集足跟血,制成干血滤纸片,先后采用放射免疫分析法(Radioimmunoassay,RIA;1987年1月~1993年8月)、时间分辨荧光免疫法(Time resolved fluoroisnmunoassay,TRFIA;1993年9月至今)检测促甲状腺激素(thyroid stimulating hormone,TSH),可疑阳性患儿召回检测甲状腺功能,确诊患儿给予规范治疗并定期随访。结果1325810例新生儿中确诊先天性甲状腺功能减低症、高TSH血症共664例,统计发病率为1/1997。早产患儿中永久性甲减者较多,体重、分娩方式与患儿预后没有明显相关性。结论新生儿筛查可早期发现先天性甲状腺功能减低症,早期诊断和规范治疗有助于改善患儿预后。
Objective:To retrospectively analyze neonatal screening for congenital hypothyroidism in Nanjing.Methods:Select 1325810 newborn children who born in Nanjing from January 1987 to December 2019,the samples of neonatal heel blood filter paper were collected at 48—72h after infant birth and adequate lactation,adopt RIA(from January 1987 to August 1993)and DEFIA(from September 1993 so far)measure TSH,suspicious positive cases were recalled to test thyroid,confirmed cases were given standardized treatment and regular follow-up.Results:664 children have been diagnosed as CH and High?TSH Hyperthyroidemia,the incidence is 1/1997,there was no correlation between weight and delivery way,preterm children have?obvious?relativity?with permanency CH.Conclusion:Neonatal screening for congenital hypothyroidism can find cases early,and standardized treatment early,which contribute to improve prognosis.
作者
管贤伟
梁晓威
程威
陈玉林
GUAN Xian-wei;LIANG Xiao-wei;CHENG Wei;CHEN Yu-lin(New Screening Center of Women′s Hospital of Nanjing Medical University(Nanjing Maternity and Child Heath Care Hospital)Centre for Genetic Medicine,Nanjing 210004;New Screening Center of Women′s Hospital of Nanjing Medical University(Nanjing Maternity and Child Heath Care Hospital)Department of Paediatrics,Nanjing 210004)
出处
《中国优生与遗传杂志》
2020年第7期863-865,共3页
Chinese Journal of Birth Health & Heredity
