抑郁症发展成为应激与个体对应激易感性的相互作用的结果,早期的生活压力和基因–环境相互作用可能是抑郁症的危险因素,并在个体应激易感的进展中发挥重要作用。糖皮质激素受体基因启动子的表观调节被认为是应激易感性的分子基础。脑源...抑郁症发展成为应激与个体对应激易感性的相互作用的结果,早期的生活压力和基因–环境相互作用可能是抑郁症的危险因素,并在个体应激易感的进展中发挥重要作用。糖皮质激素受体基因启动子的表观调节被认为是应激易感性的分子基础。脑源性神经营养因子启动子的组蛋白修饰可能是抗抑郁药和电休克治疗的调节机制。临床遗传学研究表明基因组印记参与了双向障碍的发病,但还没有直接的分子证据的报道。通过组蛋白脱乙酰基酶抑制剂-丙戊酸盐及DNA甲基化供体-S-腺苷甲硫氨酸的抗躁狂作用的研究,认为DNA甲基化参与了情绪的调节。双向障碍患者的尸检发现,其脑组织膜结合儿茶酚胺-O-甲基转移酶的启动子区的DNA存在甲基化改变。一对患有双向障碍单卵双生的双胞胎的PPIEL被发现存在DNA甲基化状态。在一个双向障碍II型的对照病例中发现PPIEL低甲基化。这些研究结果表明表观遗传在情感障碍中可能发生作用。对情感障碍的表观遗传机制的进一步研究是必要的。Depression developed into a result of the interaction of stress and individual stress susceptibility, the possible risk factors were the early life pressure and gene-environment interaction, which played an important role in the development of individual stress susceptibility. The glucocorticoid receptor gene promoter apparent adjustment was considered to be the molecular basis of the susceptibility of stress. Brain-deried neurotrophic factor promoters of the protein modification may be antidepressants and electric shock treatment of adjustment mechanism. Clinical genetics research indicated that genomic imprinting involved in the biplor disorder come on, but had no direct evidence of the molecules of the report. Through the research resistance to manic function of group of protein deacelation base enzyme inhibitors-valproic acid salt and DNA methylation donor-S-adenosine armour sulfur acid, showed that DNA methylation involved in emotional adjustment. Two-way barrier patient autopsy discovered that the brain membrane combined with catecholamine-O-phenol-o-methyl shift enzyme promoter of the DNA methylation change there. A single egg with two-way obstacles of twins shared the PPIEL was found DNA methylation state. The conclusion was that epigenetic may act in emotional disorders. It was necessary for further study of epigenetic mechanisms of affective disorder.展开更多
目的:针对抑郁症群体年轻化趋势,本研究致力于探究绘画团体辅导在初中学生群体中对抑郁症状和整体心理健康水平的影响,为青少年抑郁症状干预提供科学有效的普适性方法。方法:选取山东省威海市某四年制初中学校存在抑郁症状的80名学生作...目的:针对抑郁症群体年轻化趋势,本研究致力于探究绘画团体辅导在初中学生群体中对抑郁症状和整体心理健康水平的影响,为青少年抑郁症状干预提供科学有效的普适性方法。方法:选取山东省威海市某四年制初中学校存在抑郁症状的80名学生作为研究对象,随机分为实验组40人(绘画团体辅导)和对照组40人(学校标准课程)。通过流调用抑郁量表(CES-D)和中小学生心理健康诊断测验(MHT)来测量绘画团体辅导的干预效果。试验结束后的3个月和9个月,采用流调用抑郁量表进行随访。结果:实验组CES-D基线的均数与干预后、3月后、9月后量表得分总体均数相比,存在统计学差异(F = 3.93, P = 0.01);时间和处理因素交互效应无统计学意义(P = 0.15);实验组和对照组在干预后CES-D得分,有统计学差异(t = 3.56, P = 0.001)。MHT量表总分在干预后两组存在统计学差异(Z = −2.32, P = 0.023);学习压力得分在干预后两组无统计学差异(t = −0.7, P = 0.49)。干预后,达到临床显著改善实验组与对照组相比,两组有明显统计学差异(χ2 = 15.22, P = 0.001)。结论:本研究结果支持绘画团体辅导对初中学生抑郁症状的改善是有效的,且这种改善效果在随访过程中得以持续。绘画团体辅导可以作为一种简便而有效的干预方法,为初中生的健康成长发挥积极作用。Objective: In response to the trend of youth depression, this study aims to explore the effects of group art therapy on depression symptoms and overall mental health in junior high school students, and provide a scientifically effective and universally applicable method for intervention of adolescent depression. Methods: 80 students with depression symptoms from a four-year junior high school in Weihai, Shandong province, China were randomly divided into an experimental group (group art therapy, n = 40) and a control group (standard school curriculum, n = 40). The intervention effects of group art therapy were measured using the Center for Epidemiologic Studies Depression Scale (CES-D) and the Mental Health Test for Primary and Secondary School Students (MHT). Follow-up assessments were conducted at 3 months and 9 months after the end of the intervention using CES-D. Results: There was a statistically significant difference between the experimental group and control group in terms of CES-D scores after the intervention (t = 3.56, P = 0.001). The baseline mean of CES-D scores in the experimental group was significantly different from the mean scores after the intervention, at 3 months, and at 9 months (F = 3.93, P = 0.01). There was no significant interaction effect between time and treatment factors (P = 0.15). There was a statistically significant difference between the two groups in terms of MHT total scores after the intervention (Z = −2.32, P = 0.023), but no significant difference in learning stress scores (t = −0.7, P = 0.49). The experimental group had significantly more participants achieving clinically significant improvement compared to the control group (χ2 = 15.22, P = 0.001). Conclusion: The results of this study support the effectiveness of group art therapy in improving depression symptoms in junior high school students, with sustained effectiveness observed during follow-up. Group art therapy can be considered as a simple and effective intervention method, playing a positive role in the healthy development of junior high school students.展开更多
目的:研究自评健康和日常生活活动能力(ADL)对老年人抑郁的影响,为其防治提供数据支撑。方法:利用2018年中国老年健康数据调查的数据,以9969例老年人为研究对象,抑郁的测量采用流调中心抑郁量表。利用卡方检验和二元Logistic回归分析分...目的:研究自评健康和日常生活活动能力(ADL)对老年人抑郁的影响,为其防治提供数据支撑。方法:利用2018年中国老年健康数据调查的数据,以9969例老年人为研究对象,抑郁的测量采用流调中心抑郁量表。利用卡方检验和二元Logistic回归分析分析影响老年人抑郁的因素。构建多层感知器(MLP)的神经网络,探究自评健康和ADL对老年人抑郁的影响的重要性。结果:二元Logistic回归分析的结果显示:女性(OR = 1.119, 95% CI = 1.031~1.214)、农村(OR = 1.380, 95% CI = 1.260~1.511)、≥85岁(OR = 1.311, 95% CI = 1.199~1.433)、ADL失能(OR = 1.283, 95% CI = 1.145~1.439)、独居(OR = 1.311, 95% CI = 1.174~1.465)、居住在养老机构(OR = 1.544, 95% CI = 1.228~1.940)、自评健康一般(OR = 1.492, 95% CI = 1.367~1.629)、自评健康不好(OR = 2.728, 95% CI = 2.386~3.118)、经济状况一般(OR = 1.144, 95% CI = 1.030~1.270)及经济状况困难(OR = 1.723, 95% CI = 1.457~2.037)会增加老年人抑郁的风险。MLP神经网络的重要性排序:自评健康(0.258)、ADL(0.233)、经济状况(0.188)、年龄(0.156)、居住方式(0.088)、民族(0.035)、城乡分布(0.027)、性别(0.026)。结论:自评健康和ADL都会影响老年人抑郁,且自评健康的重要性大于ADL的重要性。改善老年人自评健康状况,鼓励ADL失能的老年人进行康复训练并经常安排心理疏导,有助于降低老年人发生抑郁的风险。Objective: To study the effects of self-rated health and activities of daily living on depression in the elderly, and to provide data support for its Prevention and treatment. Methods: Based on the data of the 2018 China Elderly Health Data Survey, 9969 elderly people were selected as the research objects, and depression was measured using center for epidemiologic studies depression scale. Chi-square test and binary logistic regression analysis were used to analyze the factors influencing depression in the elderly. The importance of constructing a neural network with multilayer perceptron to explore the impact of self-rated health and daily living ability on depression in older adults. Results: The results of binary logistic regression analysis showed that female (OR = 1.119, 95% CI = 1.031~1.214), rural (OR = 1.380, 95% CI = 1.260~1.511), ≥85 years old (OR = 1.311, 95% CI = 1.199~1.433), ADL disability (OR = 1.283, 95% CI = 1.145~1.439), and living alone (OR = 1.311, 95% CI = 1.174~1.465), living in nursing institutions (OR = 1.544, 95% CI = 1.228~1.940), self-rated average healthy (OR = 1.492, 95% CI = 1.367~1.629), self-rated poor healthy (OR = 2.728, 95% CI = 2.386~3.118), average economic status (OR = 1.144, 95% CI = 1.030~1.270), and difficult economic status (OR = 1.723, 95% CI = 1.457~2.037) increased the risk of depression in older adults. The importance ranking of MLP neural networks was self-rated health (0.258), ADL (0.233), economic status (0.188), age (0.156), residence style (0.088), ethnicity (0.035), urban-rural distribution (0.027), and gender (0.026). Conclusion: Both self-rated health and ability to perform activities of daily living affect depression in older adults, and the importance of self-rated health is greater than that of activities of daily living. Improving the self-rated health status of older adults, encouraging rehabilitation training for older adults with ADL disability, and arranging psychological counseling frequently can help reduce the risk of depression in older adults.展开更多
文摘抑郁症发展成为应激与个体对应激易感性的相互作用的结果,早期的生活压力和基因–环境相互作用可能是抑郁症的危险因素,并在个体应激易感的进展中发挥重要作用。糖皮质激素受体基因启动子的表观调节被认为是应激易感性的分子基础。脑源性神经营养因子启动子的组蛋白修饰可能是抗抑郁药和电休克治疗的调节机制。临床遗传学研究表明基因组印记参与了双向障碍的发病,但还没有直接的分子证据的报道。通过组蛋白脱乙酰基酶抑制剂-丙戊酸盐及DNA甲基化供体-S-腺苷甲硫氨酸的抗躁狂作用的研究,认为DNA甲基化参与了情绪的调节。双向障碍患者的尸检发现,其脑组织膜结合儿茶酚胺-O-甲基转移酶的启动子区的DNA存在甲基化改变。一对患有双向障碍单卵双生的双胞胎的PPIEL被发现存在DNA甲基化状态。在一个双向障碍II型的对照病例中发现PPIEL低甲基化。这些研究结果表明表观遗传在情感障碍中可能发生作用。对情感障碍的表观遗传机制的进一步研究是必要的。Depression developed into a result of the interaction of stress and individual stress susceptibility, the possible risk factors were the early life pressure and gene-environment interaction, which played an important role in the development of individual stress susceptibility. The glucocorticoid receptor gene promoter apparent adjustment was considered to be the molecular basis of the susceptibility of stress. Brain-deried neurotrophic factor promoters of the protein modification may be antidepressants and electric shock treatment of adjustment mechanism. Clinical genetics research indicated that genomic imprinting involved in the biplor disorder come on, but had no direct evidence of the molecules of the report. Through the research resistance to manic function of group of protein deacelation base enzyme inhibitors-valproic acid salt and DNA methylation donor-S-adenosine armour sulfur acid, showed that DNA methylation involved in emotional adjustment. Two-way barrier patient autopsy discovered that the brain membrane combined with catecholamine-O-phenol-o-methyl shift enzyme promoter of the DNA methylation change there. A single egg with two-way obstacles of twins shared the PPIEL was found DNA methylation state. The conclusion was that epigenetic may act in emotional disorders. It was necessary for further study of epigenetic mechanisms of affective disorder.
文摘目的:针对抑郁症群体年轻化趋势,本研究致力于探究绘画团体辅导在初中学生群体中对抑郁症状和整体心理健康水平的影响,为青少年抑郁症状干预提供科学有效的普适性方法。方法:选取山东省威海市某四年制初中学校存在抑郁症状的80名学生作为研究对象,随机分为实验组40人(绘画团体辅导)和对照组40人(学校标准课程)。通过流调用抑郁量表(CES-D)和中小学生心理健康诊断测验(MHT)来测量绘画团体辅导的干预效果。试验结束后的3个月和9个月,采用流调用抑郁量表进行随访。结果:实验组CES-D基线的均数与干预后、3月后、9月后量表得分总体均数相比,存在统计学差异(F = 3.93, P = 0.01);时间和处理因素交互效应无统计学意义(P = 0.15);实验组和对照组在干预后CES-D得分,有统计学差异(t = 3.56, P = 0.001)。MHT量表总分在干预后两组存在统计学差异(Z = −2.32, P = 0.023);学习压力得分在干预后两组无统计学差异(t = −0.7, P = 0.49)。干预后,达到临床显著改善实验组与对照组相比,两组有明显统计学差异(χ2 = 15.22, P = 0.001)。结论:本研究结果支持绘画团体辅导对初中学生抑郁症状的改善是有效的,且这种改善效果在随访过程中得以持续。绘画团体辅导可以作为一种简便而有效的干预方法,为初中生的健康成长发挥积极作用。Objective: In response to the trend of youth depression, this study aims to explore the effects of group art therapy on depression symptoms and overall mental health in junior high school students, and provide a scientifically effective and universally applicable method for intervention of adolescent depression. Methods: 80 students with depression symptoms from a four-year junior high school in Weihai, Shandong province, China were randomly divided into an experimental group (group art therapy, n = 40) and a control group (standard school curriculum, n = 40). The intervention effects of group art therapy were measured using the Center for Epidemiologic Studies Depression Scale (CES-D) and the Mental Health Test for Primary and Secondary School Students (MHT). Follow-up assessments were conducted at 3 months and 9 months after the end of the intervention using CES-D. Results: There was a statistically significant difference between the experimental group and control group in terms of CES-D scores after the intervention (t = 3.56, P = 0.001). The baseline mean of CES-D scores in the experimental group was significantly different from the mean scores after the intervention, at 3 months, and at 9 months (F = 3.93, P = 0.01). There was no significant interaction effect between time and treatment factors (P = 0.15). There was a statistically significant difference between the two groups in terms of MHT total scores after the intervention (Z = −2.32, P = 0.023), but no significant difference in learning stress scores (t = −0.7, P = 0.49). The experimental group had significantly more participants achieving clinically significant improvement compared to the control group (χ2 = 15.22, P = 0.001). Conclusion: The results of this study support the effectiveness of group art therapy in improving depression symptoms in junior high school students, with sustained effectiveness observed during follow-up. Group art therapy can be considered as a simple and effective intervention method, playing a positive role in the healthy development of junior high school students.
文摘目的:研究自评健康和日常生活活动能力(ADL)对老年人抑郁的影响,为其防治提供数据支撑。方法:利用2018年中国老年健康数据调查的数据,以9969例老年人为研究对象,抑郁的测量采用流调中心抑郁量表。利用卡方检验和二元Logistic回归分析分析影响老年人抑郁的因素。构建多层感知器(MLP)的神经网络,探究自评健康和ADL对老年人抑郁的影响的重要性。结果:二元Logistic回归分析的结果显示:女性(OR = 1.119, 95% CI = 1.031~1.214)、农村(OR = 1.380, 95% CI = 1.260~1.511)、≥85岁(OR = 1.311, 95% CI = 1.199~1.433)、ADL失能(OR = 1.283, 95% CI = 1.145~1.439)、独居(OR = 1.311, 95% CI = 1.174~1.465)、居住在养老机构(OR = 1.544, 95% CI = 1.228~1.940)、自评健康一般(OR = 1.492, 95% CI = 1.367~1.629)、自评健康不好(OR = 2.728, 95% CI = 2.386~3.118)、经济状况一般(OR = 1.144, 95% CI = 1.030~1.270)及经济状况困难(OR = 1.723, 95% CI = 1.457~2.037)会增加老年人抑郁的风险。MLP神经网络的重要性排序:自评健康(0.258)、ADL(0.233)、经济状况(0.188)、年龄(0.156)、居住方式(0.088)、民族(0.035)、城乡分布(0.027)、性别(0.026)。结论:自评健康和ADL都会影响老年人抑郁,且自评健康的重要性大于ADL的重要性。改善老年人自评健康状况,鼓励ADL失能的老年人进行康复训练并经常安排心理疏导,有助于降低老年人发生抑郁的风险。Objective: To study the effects of self-rated health and activities of daily living on depression in the elderly, and to provide data support for its Prevention and treatment. Methods: Based on the data of the 2018 China Elderly Health Data Survey, 9969 elderly people were selected as the research objects, and depression was measured using center for epidemiologic studies depression scale. Chi-square test and binary logistic regression analysis were used to analyze the factors influencing depression in the elderly. The importance of constructing a neural network with multilayer perceptron to explore the impact of self-rated health and daily living ability on depression in older adults. Results: The results of binary logistic regression analysis showed that female (OR = 1.119, 95% CI = 1.031~1.214), rural (OR = 1.380, 95% CI = 1.260~1.511), ≥85 years old (OR = 1.311, 95% CI = 1.199~1.433), ADL disability (OR = 1.283, 95% CI = 1.145~1.439), and living alone (OR = 1.311, 95% CI = 1.174~1.465), living in nursing institutions (OR = 1.544, 95% CI = 1.228~1.940), self-rated average healthy (OR = 1.492, 95% CI = 1.367~1.629), self-rated poor healthy (OR = 2.728, 95% CI = 2.386~3.118), average economic status (OR = 1.144, 95% CI = 1.030~1.270), and difficult economic status (OR = 1.723, 95% CI = 1.457~2.037) increased the risk of depression in older adults. The importance ranking of MLP neural networks was self-rated health (0.258), ADL (0.233), economic status (0.188), age (0.156), residence style (0.088), ethnicity (0.035), urban-rural distribution (0.027), and gender (0.026). Conclusion: Both self-rated health and ability to perform activities of daily living affect depression in older adults, and the importance of self-rated health is greater than that of activities of daily living. Improving the self-rated health status of older adults, encouraging rehabilitation training for older adults with ADL disability, and arranging psychological counseling frequently can help reduce the risk of depression in older adults.
