MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices tak...MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices take the advantage of the exceptional electrical conductivity,mechanical flexibility,and biocompatibility of two-dimensional MXenes to enable noninvasive,tear-based monitoring of key physiological markers such as intraocular pressure and glucose levels.Recent developments focus on the integration of transparent MXene films into the conventional lens materials,allowing multifunctional performance including photothermal therapy,antimicrobial and anti-inflammation protection,and dehydration resistance.These innovations offer promising strategies for ocular disease management and eye protection.In addition to their multifunctionality,improvements in MXene synthesis and device engineering have enhanced the stability,transparency,and wearability of these lenses.Despite these advances,challenges remain in long-term biostability,scalable production,and integration with wireless communication systems.This review summarizes the current progress,key challenges,and future directions of MXene-based smart contact lenses,highlighting their transformative potential in next-generation digital healthcare and ophthalmic care.展开更多
Objectives: To report the 2-years follow-up of patients with bulbar urethral strictures treated with the new AlliumTM Bulbar Urethral Stent (Allium BUS). Methods: The stent is a fully covered, self-expendable, large c...Objectives: To report the 2-years follow-up of patients with bulbar urethral strictures treated with the new AlliumTM Bulbar Urethral Stent (Allium BUS). Methods: The stent is a fully covered, self-expendable, large caliber metal stent specially designed for the treatment of bulbar urethral strictures. The stent is comprised of a coiled super-elastic structure covered by a polymeric coating designed to prevent mucosal hyperplasia. The indwelling time is 12 months, after which the stent should have been removed. Sixty-four patients with recurrent bulbar stricture were treated with Allium BUS in 3 worldwide centers. Results: All stents were successfully inserted with no perioperative complications. In a median follow-up of 25.5 months, the mean maximal flow rate following stent insertion was significantly higher compared to the pre-surgical flow rate (14 ml/sec vs 6.6 ml/sec, p < 0.0001). Longer indwelling time and shorter stricture length were significantly related to success rate. The main complications were stent migration, stent re-stenosis and urinary tract infections. Conclusions: The temporary placement of the AlliumTM BUS showed encouraging results with long-term failure rate of only 25%.展开更多
AIM:To evaluate certain anthropometric,clinical and laboratory features indicating liver fibrosis in nonalcoholic steatohepatitis and to establish the noninvasive markers for liver fibrosis.METHODS:Eighty-one patients...AIM:To evaluate certain anthropometric,clinical and laboratory features indicating liver fibrosis in nonalcoholic steatohepatitis and to establish the noninvasive markers for liver fibrosis.METHODS:Eighty-one patients (40 male,41 female) who were diagnosed with fatty liver by ultrasonographic examination and fulfilled the inclusion criteria participated in the study.Anamnesis,anthropometric,clinical and laboratory features of all cases were recorded and then liver biopsy was performed after obtaining patient consent.Steatosis,necroinflammation and liver fibrosis were examined according to age ≥ 45,gender,body mass index,central obesity,aspartate amino-transferase (AST)/alanine aminotransferase (ALT)>1,γ-glutamyltransferase (GGT)/ALT>1,platelet count,insulin,c-peptide levels and the presence of hypertension,diabetes,hypertriglyceridemia and insulin resis-tance.RESULTS:Eighty-one patients with non-alcoholic steatohepatitis (NASH) enrolled in the study.69 of 81 patients were diagnosed with NASH,11 were diagnosed with simple fatty liver and 1 was diagnosed with cirrhosis.AST/ALT>1,GGT/ALT>11,high serum ferritin and fasting insulin levels,the presence of diabetes,hypertension,hypertriglyceridemia and insulin resistance seemed to enhance the severity of steatosis,necroinflammation and fibrosis but these results were not statistically significant.CONCLUSION:Liver steatosis and fibrosis can occur in individuals with normal weight.There was no significant concordance between severity of liver histology and the presence of predictors for liver fibrosis including metabolic risk factors.展开更多
Previous studies in literatures adequately emphasized that inserting fins into phase change material is among the most promising techniques to augment thermal performance of shell-and-tube latent heat thermal energy s...Previous studies in literatures adequately emphasized that inserting fins into phase change material is among the most promising techniques to augment thermal performance of shell-and-tube latent heat thermal energy storage unit.In this study,the novel unequal-length fins are designed from the perspective of synergistic benefits of heat transfer and energy storage performance,and the effects of arrangement,number and total length of unequal-length fins are numerically investigated.Results show that utilization of fins with ascending length,when short and long fins are located in the inlet and outlet of heat transfer fluid respectively,can further promote the heat transfer and energy storage performance compared with equal length fins,and a maximum 6.17%and 0.43%increment of heat transfer performance and stored energy is achieved in full melting time,respectively.The number of unequal-length fins plays a major role in the energy storage,and 18.95%and 0.91%improvement of heat transfer performance and stored energy is realized when equipped with 2 unequal-length fins.A 21.17%improvement of the heat transfer performance is obtained when the total length of unequal-length fins is 18 mm.The present study is helpful to make further efforts to enhance heat transfer and energy storage of shell-and-tube latent heat thermal energy storage unit with unequal-length fins.展开更多
文摘MXene-based smart contact lenses demonstrate a cutting-edge advancement in wearable ophthalmic technology,combining real-time biosensing,therapeutic capabilities,and user comfort in a single platform.These devices take the advantage of the exceptional electrical conductivity,mechanical flexibility,and biocompatibility of two-dimensional MXenes to enable noninvasive,tear-based monitoring of key physiological markers such as intraocular pressure and glucose levels.Recent developments focus on the integration of transparent MXene films into the conventional lens materials,allowing multifunctional performance including photothermal therapy,antimicrobial and anti-inflammation protection,and dehydration resistance.These innovations offer promising strategies for ocular disease management and eye protection.In addition to their multifunctionality,improvements in MXene synthesis and device engineering have enhanced the stability,transparency,and wearability of these lenses.Despite these advances,challenges remain in long-term biostability,scalable production,and integration with wireless communication systems.This review summarizes the current progress,key challenges,and future directions of MXene-based smart contact lenses,highlighting their transformative potential in next-generation digital healthcare and ophthalmic care.
文摘Objectives: To report the 2-years follow-up of patients with bulbar urethral strictures treated with the new AlliumTM Bulbar Urethral Stent (Allium BUS). Methods: The stent is a fully covered, self-expendable, large caliber metal stent specially designed for the treatment of bulbar urethral strictures. The stent is comprised of a coiled super-elastic structure covered by a polymeric coating designed to prevent mucosal hyperplasia. The indwelling time is 12 months, after which the stent should have been removed. Sixty-four patients with recurrent bulbar stricture were treated with Allium BUS in 3 worldwide centers. Results: All stents were successfully inserted with no perioperative complications. In a median follow-up of 25.5 months, the mean maximal flow rate following stent insertion was significantly higher compared to the pre-surgical flow rate (14 ml/sec vs 6.6 ml/sec, p < 0.0001). Longer indwelling time and shorter stricture length were significantly related to success rate. The main complications were stent migration, stent re-stenosis and urinary tract infections. Conclusions: The temporary placement of the AlliumTM BUS showed encouraging results with long-term failure rate of only 25%.
基金Supported by The Uludag University Scientific Project Grant
文摘AIM:To evaluate certain anthropometric,clinical and laboratory features indicating liver fibrosis in nonalcoholic steatohepatitis and to establish the noninvasive markers for liver fibrosis.METHODS:Eighty-one patients (40 male,41 female) who were diagnosed with fatty liver by ultrasonographic examination and fulfilled the inclusion criteria participated in the study.Anamnesis,anthropometric,clinical and laboratory features of all cases were recorded and then liver biopsy was performed after obtaining patient consent.Steatosis,necroinflammation and liver fibrosis were examined according to age ≥ 45,gender,body mass index,central obesity,aspartate amino-transferase (AST)/alanine aminotransferase (ALT)>1,γ-glutamyltransferase (GGT)/ALT>1,platelet count,insulin,c-peptide levels and the presence of hypertension,diabetes,hypertriglyceridemia and insulin resis-tance.RESULTS:Eighty-one patients with non-alcoholic steatohepatitis (NASH) enrolled in the study.69 of 81 patients were diagnosed with NASH,11 were diagnosed with simple fatty liver and 1 was diagnosed with cirrhosis.AST/ALT>1,GGT/ALT>11,high serum ferritin and fasting insulin levels,the presence of diabetes,hypertension,hypertriglyceridemia and insulin resistance seemed to enhance the severity of steatosis,necroinflammation and fibrosis but these results were not statistically significant.CONCLUSION:Liver steatosis and fibrosis can occur in individuals with normal weight.There was no significant concordance between severity of liver histology and the presence of predictors for liver fibrosis including metabolic risk factors.
基金This investigation was financially supported by the National Science Foundation of China(NSFC)(No.52078110)the Natural Science Foundation of Heilongjiang Province(No.LH2019E015)the Scientific Project of Ministry of Housing and Urban-Rural Development of China(No.2020-K-184,No.2021-K-160).
文摘Previous studies in literatures adequately emphasized that inserting fins into phase change material is among the most promising techniques to augment thermal performance of shell-and-tube latent heat thermal energy storage unit.In this study,the novel unequal-length fins are designed from the perspective of synergistic benefits of heat transfer and energy storage performance,and the effects of arrangement,number and total length of unequal-length fins are numerically investigated.Results show that utilization of fins with ascending length,when short and long fins are located in the inlet and outlet of heat transfer fluid respectively,can further promote the heat transfer and energy storage performance compared with equal length fins,and a maximum 6.17%and 0.43%increment of heat transfer performance and stored energy is achieved in full melting time,respectively.The number of unequal-length fins plays a major role in the energy storage,and 18.95%and 0.91%improvement of heat transfer performance and stored energy is realized when equipped with 2 unequal-length fins.A 21.17%improvement of the heat transfer performance is obtained when the total length of unequal-length fins is 18 mm.The present study is helpful to make further efforts to enhance heat transfer and energy storage of shell-and-tube latent heat thermal energy storage unit with unequal-length fins.
