The increasing focus on electrocatalysis for sustainable hydrogen(H_(2))production has prompted significant interest in MXenes,a class of two-dimensional(2D)materials comprising metal carbides,carbonitrides,and nitrid...The increasing focus on electrocatalysis for sustainable hydrogen(H_(2))production has prompted significant interest in MXenes,a class of two-dimensional(2D)materials comprising metal carbides,carbonitrides,and nitrides.These materials exhibit intriguing chemical and physical properties,including excellent electrical conductivity and a large surface area,making them attractive candidates for the hydrogen evolution reaction(HER).This scientific review explores recent advancements in MXene-based electrocatalysts for HER kinetics.It discusses various compositions,functionalities,and explicit design principles while providing a comprehensive overview of synthesis methods,exceptional properties,and electro-catalytic approaches for H_(2) production via electrochemical reactions.Furthermore,challenges and future prospects in designing MXenes-based electrocatalysts with enhanced kinetics are highlighted,emphasizing the potential of incorporating different metals to expand the scope of electrochemical reactions.This review suggests possible efforts for developing advanced MXenes-based electrocatalysts,particularly for efficient H_(2) generation through electrochemical water-splitting reactions..展开更多
The removal of bisphenol A (BPA) in seawater using microalgae is still a challenge due to the low removal efficiency and weak tolerance. A novel Oocystis algal strain was isolated for BPA removal with an efficiency (&...The removal of bisphenol A (BPA) in seawater using microalgae is still a challenge due to the low removal efficiency and weak tolerance. A novel Oocystis algal strain was isolated for BPA removal with an efficiency (> 98%) over two times higher than that of the common microalgae Chlorella (42.8%). The maximal carbon capture rate of Oocystis was 0.16 g/(L·d) which was much higher than that of Chlorella (0.06 g/(L·d)). The BPA removal fitted a first-order kinetic model and Oocystis showed a maximum removal rate of 29.80 µg/(L·d) at a BPA concentration of 2000 µg/L. The new Oocystis strain had a wide range of pH adaptability for BPA removal. The sharp increase in peroxidase (POD) activity indicated its involvement in BPA degradation. Transcriptome analysis showed that BPA mainly affected the photosynthesis-related genes while the engagement of glutathione POD in the BPA biodegradation was confirmed. BPA could also serve as growth promoter for Oocystis during the removal process, which subsequently enhanced the growth and carbon capture. BPA could be removed by the Oocystis strain through hydroxylation, demethylation, and conjugation. The Oocystis strain still maintained high BPA removal efficiency (100%) and carbon capture rate (0.2 g/(L·d)) in the pilot-scale tailwater treatment system, illustrating microalgal processes were efficient for marine pollution control. This study also provides new ideas for developing low-cost carbon capture technologies to achieve the goal of carbon neutrality.展开更多
Signal transducer and activator of transcription 3(STAT3)is a member of the transcription factors involved in regulating many physiological and pathological processes,such as cell proliferation,angiogenesis and immune...Signal transducer and activator of transcription 3(STAT3)is a member of the transcription factors involved in regulating many physiological and pathological processes,such as cell proliferation,angiogenesis and immune escape.STAT3 has been identified as a potential therapeutic target for various cancers.Although numerous STAT3 inhibitors have been discovered and optimized to directly inhibit STAT3 activity,they are not yet authorized for clinical use and only a few have entered clinical trials.Furthermore,several proteolysis-targeting chimera(PROTAC)molecules with STAT3 degrading effects have been developed.The event-driven action of PROTAC overcome the drawbacks of STAT3,a traditional undruggable target,and addressed possible resistance to small-molecule inhibitors by degrading the entire STAT3 protein.In this review,we presented a brief introduction to STAT3 and its functions in various cancers,and systematically overviewed the pharmacological effects of inhibitors targeting different domains of STAT3 in the last three years,the structural characterization of the main scaffold,the design strategies,and the pharmacological activities of the substituents.Also,the binding patterns and interactions of some inhibitors with STAT3 were analyzed in detail and the recent advances in STAT3 degraders are also summarized.We anticipate that this perspective will contribute to the design and optimize more novel effective and specific STAT3 inhibitors or degraders for carcinoma treatment.展开更多
Snow cover plays a critical role in global climate regulation and hydrological processes.Accurate monitoring is essential for understanding snow distribution patterns,managing water resources,and assessing the impacts...Snow cover plays a critical role in global climate regulation and hydrological processes.Accurate monitoring is essential for understanding snow distribution patterns,managing water resources,and assessing the impacts of climate change.Remote sensing has become a vital tool for snow monitoring,with the widely used Moderate-resolution Imaging Spectroradiometer(MODIS)snow products from the Terra and Aqua satellites.However,cloud cover often interferes with snow detection,making cloud removal techniques crucial for reliable snow product generation.This study evaluated the accuracy of four MODIS snow cover datasets generated through different cloud removal algorithms.Using real-time field camera observations from four stations in the Tianshan Mountains,China,this study assessed the performance of these datasets during three distinct snow periods:the snow accumulation period(September-November),snowmelt period(March-June),and stable snow period(December-February in the following year).The findings showed that cloud-free snow products generated using the Hidden Markov Random Field(HMRF)algorithm consistently outperformed the others,particularly under cloud cover,while cloud-free snow products using near-day synthesis and the spatiotemporal adaptive fusion method with error correction(STAR)demonstrated varying performance depending on terrain complexity and cloud conditions.This study highlighted the importance of considering terrain features,land cover types,and snow dynamics when selecting cloud removal methods,particularly in areas with rapid snow accumulation and melting.The results suggested that future research should focus on improving cloud removal algorithms through the integration of machine learning,multi-source data fusion,and advanced remote sensing technologies.By expanding validation efforts and refining cloud removal strategies,more accurate and reliable snow products can be developed,contributing to enhanced snow monitoring and better management of water resources in alpine and arid areas.展开更多
Quantification of river flood risks is a prerequisite for floodplain management and development.The lower Yellow River(LYR)is characterized by a complex channel–floodplain system,which is prone to flooding but inhabi...Quantification of river flood risks is a prerequisite for floodplain management and development.The lower Yellow River(LYR)is characterized by a complex channel–floodplain system,which is prone to flooding but inhabits a large population on the floodplains.Many floodplain management modes have been presented,but implementation effects of these management modes have not been evaluated correctly.An integrated model was first proposed to evaluate the flood risks to people’s life and property,covering an improved module of two-dimensional(2D)morphodynamic processes and a module of flood risk evaluation for people,buildings and crops on the floodplains.Two simulation cases were then conducted to validate the model accuracy,including the hyperconcentrated flood event and dike-breach induced flood event occurring in the LYR.Finally,the integrated model was applied to key floodplains in the LYR,and the effects of different floodplain management modes were quantified on the risks to people’s life and property under an extreme flood event.Results indicate that:①Satisfactory accuracy was achieved in the simulation of these two flood events.The maximum sediment concentration was just underestimated by 9%,and the simulated inundation depth agreed well with the field record;②severe inundation was predicted to occur in most domains under the current topography(SchemeⅠ),which would be alleviated after implementing different floodplain management modes,with the area in slight inundation degree accounting for a large proportion under the mode of“construction of protection embankment”(SchemeⅡ)and the area in medium inundation degree occupying a high ratio under the mode of“floodplain partition harnessing”(SchemeⅢ);and③compared with SchemeⅠ,the high-risk area for people’s life and property would reduce by 21%–49%under SchemeⅡ,and by 35%–93%under SchemeⅢ.展开更多
In this study we report the results of a decade-long breeding program for japonica super rice made by Nanjing Branch of Chinese National Center for Rice Improvement in Jiangsu Academy of Agricultural Sciences. We conc...In this study we report the results of a decade-long breeding program for japonica super rice made by Nanjing Branch of Chinese National Center for Rice Improvement in Jiangsu Academy of Agricultural Sciences. We concluded that selection of parents with good comprehensive traits and complementary advantages and disadvantages of both parents in the hybrid combination, and early selection of high heritability traits in earlier segregating generations could significantly improve the breeding efficiency. The use of closely-linked functional markers in pyramiding of multiple genes could greatly increase breeding efficiency, avoiding time-consuming and laborious steps that were used in traditional breeding program. It is also important to coordinate the yield components with variety characteristics such as yield stability, wide adaptability, lodging resistance, and an attractive grain appearance during late growth stage of rice.展开更多
The relationship between fracture calcite veins and shale gas enrichment in the deep Ordovician Wufeng Formation-Silurian Longmaxi Formation (Wufeng-Longmaxi) shales in southern Sichuan Basin was investigated through ...The relationship between fracture calcite veins and shale gas enrichment in the deep Ordovician Wufeng Formation-Silurian Longmaxi Formation (Wufeng-Longmaxi) shales in southern Sichuan Basin was investigated through core and thin section observations, cathodoluminescence analysis, isotopic geochemistry analysis, fluid inclusion testing, and basin simulation. Tectonic fracture calcite veins mainly in the undulating part of the structure and non-tectonic fracture calcite veins are mainly formed in the gentle part of the structure. The latter, mainly induced by hydrocarbon generation, occurred at the stage of peak oil and gas generation, while the former turned up with the formation of Luzhou paleouplift during the Indosinian. Under the influence of hydrocarbon generation pressurization process, fractures were opened and closed frequently, and oil and gas episodic activities are recorded by veins. The formation pressure coefficient at the maximum paleodepth exceeds 2.0. The formation uplift stage after the Late Yanshanian is the key period for shale gas migration. Shale gas migrates along the bedding to the high part of the structure. The greater the structural fluctuation is, the more intense the shale gas migration activity is, and the loss is more. The gentler the formation is, the weaker the shale gas migration activity is, and the loss is less. The shale gas enrichment in the core of gentle anticlines and gentle synclines is relatively higher.展开更多
The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content(OHC). Here, we provide the first analysis of recent OHC cha...The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content(OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ(1 zetta J = 1021 J) using the IAP/CAS dataset and by16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Nino-Southern Oscillation(ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans,and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation.展开更多
The long-term warming of the ocean is a critical indicator of both the past and present state of the climate system. It also provides insights about the changes to come, owing to the persistence of both decadal variat...The long-term warming of the ocean is a critical indicator of both the past and present state of the climate system. It also provides insights about the changes to come, owing to the persistence of both decadal variations and secular trends,which the ocean records extremely well(Hansen et al., 2011;IPCC, 2013;Rhein et al., 2013;Trenberth et al., 2016;Abram et al., 2019).展开更多
<b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:""><span style="font-family:Verdana;"> The aim of this study was to ...<b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:""><span style="font-family:Verdana;"> The aim of this study was to investigate whether magnetic resonance spectrum (MRS) and MR imaging features can be used for non-invasive medulloblastoma subgrouping, and analyse patient characteristics and prognosis of molecular subtypes of medulloblastoma. </span><b><span style="font-family:Verdana;">Material and Methods: </span></b><span style="font-family:Verdana;">32 patients with medulloblastoma underwent MRI prior to surgical resection, 16 of them underwent MRS. MR imaging features and metabolites measured by MRS were analysed to distinguish molecular subtypes of medulloblastoma. Patient demographics, histopathological types, and prognosis of different molecular subtypes were analysed and compared respectively. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">MRS and MR imaging features </span><span style="font-family:Verdana;">differed from different individuals, but without statistical significance that involves acquiring non-quantitative MR imaging features and NAA/Cr, Cho/Cr, Lip/Cr, Glu and Gln/Cr ratio, to be used to determine molecular subtypes. There was no significant difference of the three molecular subtypes in age, gender and pathological type. The 5-year event-free survival (EFS) of SHH, WNT and non SHH/WNT subtype respectively were 75%, 57.1%, 38.1%, with no significant difference (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.382). 5-year EFS of non SHH/WNT subtype was significantly higher in ≤3 years old group than >3 years old group (</span><i><span style="font-family:Verdana;">p </span></i><span style="font-family:Verdana;">= 0.047). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> MRS and MR imaging features can’t be used to determine molecular subtypes based on our small sample study. There was no significant difference of the prognosis in the three molecular subtypes. The prognosis of ≤3 years old group of non SHH/WNT subtype is better than >3 years old group.展开更多
Applied linguistics means a wide range of actions which include addressing a few language-based problems or solving some language-based concerns.Emails stay in the leading positions for business as well as personal us...Applied linguistics means a wide range of actions which include addressing a few language-based problems or solving some language-based concerns.Emails stay in the leading positions for business as well as personal use.This popularity grabs the interest of individuals with malevolent inten-tions—phishing and spam email assaults.Email filtering mechanisms were developed incessantly to follow unwanted,malicious content advancement to protect the end-users.But prevailing solutions were focused on phishing email filtering and spam and whereas email labelling and analysis were not fully advanced.Thus,this study provides a solution related to email message body text automatic classification into phishing and email spam.This paper presents an Improved Fruitfly Optimization with Stacked Residual Recurrent Neural Network(IFFO-SRRNN)based on Applied Linguistics for Email Classification.The presented IFFO-SRRNN technique examines the intrinsic features of email for the identification of spam emails.At the preliminary level,the IFFO-SRRNN model follows the email pre-processing stage to make it compatible with further computation.Next,the SRRNN method can be useful in recognizing and classifying spam emails.As hyperparameters of the SRRNN model need to be effectually tuned,the IFFO algorithm can be utilized as a hyperparameter optimizer.To investigate the effectual email classification results of the IFFO-SRDL technique,a series of simulations were taken placed on public datasets,and the comparison outcomes highlight the enhancements of the IFFO-SRDL method over other recent approaches with an accuracy of 98.86%.展开更多
Recently Zhang et al.(2024) published their study entitled “Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: A long-term follow-up pilot study....Recently Zhang et al.(2024) published their study entitled “Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: A long-term follow-up pilot study.” The authors present three metachromatic leukodystrophy(MLD) patients treated with gene therapy and claim stabilization or even improvement, despite advanced symptomatic disease stage. The metachromatic leukodystrophy initiative(MLDi)(Schoenmakers et al., 2022), an international collaborative network and registry for MLD, urges caution in interpreting these results, as the evidence raises several critical concerns. These claims risk fostering false hope among MLD patients and their families, particularly given the significant gaps in the data provided(Fig. 1).展开更多
Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and one of the most common preventable causes of intellectual disability in the world. CH may be due to developmental or functional thyroid...Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and one of the most common preventable causes of intellectual disability in the world. CH may be due to developmental or functional thyroid defects (primary or peripheral CH) or be hypothalamic-pituitary in origin (central CH). In most cases, primary CH is caused by a developmental malformation of the gland (thyroid dysgenesis, TD) or by a defect in thyroid hormones synthesis (dyshormonogenesis, DH). TD represents about 65% of CH and a genetic cause is currently identified in fewer than 5% of patients. The remaining 35% are cases of DH and are explained with certainty at the molecular level in more than 50% of cases. The etiology of CH is mostly unknown and may include contributions from individual and environmental factors. In recent years, the detailed phenotypic description of patients, high-throughput sequencing technologies, and the use of animal models have made it possible to discover new genes involved in the development or function of the thyroid gland. This paper reviews all the genetic causes of CH. The modes by which CH is transmitted will also be discussed, including a new oligogenic model. CH is no longer simply a dominant disease for cases of CH due to TD and recessive for cases of CH due to DH, but a far more complex disorder.展开更多
Interleukin(IL)-17A,a pro-inflammatory cytokine,is a fundamental function in the onset and advancement of multiple immune diseases.To uncover the primary compounds with IL-17A inhibitory activity,a large-scale screeni...Interleukin(IL)-17A,a pro-inflammatory cytokine,is a fundamental function in the onset and advancement of multiple immune diseases.To uncover the primary compounds with IL-17A inhibitory activity,a large-scale screening of the library of traditional Chinese medicine constituents and microbial secondary metabolites was conducted using splenic cells from IL-17A-GFP reporter mice cultured under Th17-priming conditions.Our results indicated that some aureane-type sesquiterpene tetraketides isolated from a wetland mud-derived fungus,Myrothecium gramineum,showed remarkable IL-17A inhibitory activity.Nine new aureane-type sesquiterpene tetraketides,myrogramins A-I(1,4-11),and two known ones(2 and 3)were isolated and identified from the strain.Compounds 1,3,4,10,and 11 exhibited significant IL-17A inhibitory activity.Among them,compound 3,with a high fermentation yield dosedependently inhibited the generation of IL-17A and suppressed glycolysis in splenic cells under Th17-priming conditions.Strikingly,compound 3 suppressed immunopathology in both IL-17A-mediated animal models of experimental autoimmune encephalomyelitis and pulmonary hypertension.Our results revealed that aureane-type sesquiterpene tetraketides are a novel class of immunomodulators with IL-17A inhibitory activity,and hold great promise applications in treating IL-17A-mediated immune diseases.展开更多
基金the financial support from the Sunway University International Research Network Grant Scheme(STR-IRNGSSET-GAMRG-01-2022)the Universiti Kebangsaan Malaysia Grant(GUP-2022-080)。
文摘The increasing focus on electrocatalysis for sustainable hydrogen(H_(2))production has prompted significant interest in MXenes,a class of two-dimensional(2D)materials comprising metal carbides,carbonitrides,and nitrides.These materials exhibit intriguing chemical and physical properties,including excellent electrical conductivity and a large surface area,making them attractive candidates for the hydrogen evolution reaction(HER).This scientific review explores recent advancements in MXene-based electrocatalysts for HER kinetics.It discusses various compositions,functionalities,and explicit design principles while providing a comprehensive overview of synthesis methods,exceptional properties,and electro-catalytic approaches for H_(2) production via electrochemical reactions.Furthermore,challenges and future prospects in designing MXenes-based electrocatalysts with enhanced kinetics are highlighted,emphasizing the potential of incorporating different metals to expand the scope of electrochemical reactions.This review suggests possible efforts for developing advanced MXenes-based electrocatalysts,particularly for efficient H_(2) generation through electrochemical water-splitting reactions..
基金supported by the National Natural Science Foundation of China(No.42277037)the National Key R&D Program of China(Nos.2023YFD2400405 and 2023YFD2400400)+1 种基金the Taishan Scholars Program(No.tstp20240522)the Ocean Negative Carbon Emissions(ONCE)Program,and Fundamental Research Funds for the Central Universities(No.3072025YC2701).
文摘The removal of bisphenol A (BPA) in seawater using microalgae is still a challenge due to the low removal efficiency and weak tolerance. A novel Oocystis algal strain was isolated for BPA removal with an efficiency (> 98%) over two times higher than that of the common microalgae Chlorella (42.8%). The maximal carbon capture rate of Oocystis was 0.16 g/(L·d) which was much higher than that of Chlorella (0.06 g/(L·d)). The BPA removal fitted a first-order kinetic model and Oocystis showed a maximum removal rate of 29.80 µg/(L·d) at a BPA concentration of 2000 µg/L. The new Oocystis strain had a wide range of pH adaptability for BPA removal. The sharp increase in peroxidase (POD) activity indicated its involvement in BPA degradation. Transcriptome analysis showed that BPA mainly affected the photosynthesis-related genes while the engagement of glutathione POD in the BPA biodegradation was confirmed. BPA could also serve as growth promoter for Oocystis during the removal process, which subsequently enhanced the growth and carbon capture. BPA could be removed by the Oocystis strain through hydroxylation, demethylation, and conjugation. The Oocystis strain still maintained high BPA removal efficiency (100%) and carbon capture rate (0.2 g/(L·d)) in the pilot-scale tailwater treatment system, illustrating microalgal processes were efficient for marine pollution control. This study also provides new ideas for developing low-cost carbon capture technologies to achieve the goal of carbon neutrality.
基金supported by grants from the National Key Research and Development Program of China(No.2023YFA1800403)The Science and Technology Commission of Shanghai Municipality(No.21S11907800)Key Research and Development Program of Ningxia(No.2023BEG02010).
文摘Signal transducer and activator of transcription 3(STAT3)is a member of the transcription factors involved in regulating many physiological and pathological processes,such as cell proliferation,angiogenesis and immune escape.STAT3 has been identified as a potential therapeutic target for various cancers.Although numerous STAT3 inhibitors have been discovered and optimized to directly inhibit STAT3 activity,they are not yet authorized for clinical use and only a few have entered clinical trials.Furthermore,several proteolysis-targeting chimera(PROTAC)molecules with STAT3 degrading effects have been developed.The event-driven action of PROTAC overcome the drawbacks of STAT3,a traditional undruggable target,and addressed possible resistance to small-molecule inhibitors by degrading the entire STAT3 protein.In this review,we presented a brief introduction to STAT3 and its functions in various cancers,and systematically overviewed the pharmacological effects of inhibitors targeting different domains of STAT3 in the last three years,the structural characterization of the main scaffold,the design strategies,and the pharmacological activities of the substituents.Also,the binding patterns and interactions of some inhibitors with STAT3 were analyzed in detail and the recent advances in STAT3 degraders are also summarized.We anticipate that this perspective will contribute to the design and optimize more novel effective and specific STAT3 inhibitors or degraders for carcinoma treatment.
基金funded by the Third Xinjiang Scientific Expedition Program(2021xjkk1400)the National Natural Science Foundation of China(42071049)+2 种基金the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2019D01C022)the Xinjiang Uygur Autonomous Region Innovation Environment Construction Special Project&Science and Technology Innovation Base Construction Project(PT2107)the Tianshan Talent-Science and Technology Innovation Team(2022TSYCTD0006).
文摘Snow cover plays a critical role in global climate regulation and hydrological processes.Accurate monitoring is essential for understanding snow distribution patterns,managing water resources,and assessing the impacts of climate change.Remote sensing has become a vital tool for snow monitoring,with the widely used Moderate-resolution Imaging Spectroradiometer(MODIS)snow products from the Terra and Aqua satellites.However,cloud cover often interferes with snow detection,making cloud removal techniques crucial for reliable snow product generation.This study evaluated the accuracy of four MODIS snow cover datasets generated through different cloud removal algorithms.Using real-time field camera observations from four stations in the Tianshan Mountains,China,this study assessed the performance of these datasets during three distinct snow periods:the snow accumulation period(September-November),snowmelt period(March-June),and stable snow period(December-February in the following year).The findings showed that cloud-free snow products generated using the Hidden Markov Random Field(HMRF)algorithm consistently outperformed the others,particularly under cloud cover,while cloud-free snow products using near-day synthesis and the spatiotemporal adaptive fusion method with error correction(STAR)demonstrated varying performance depending on terrain complexity and cloud conditions.This study highlighted the importance of considering terrain features,land cover types,and snow dynamics when selecting cloud removal methods,particularly in areas with rapid snow accumulation and melting.The results suggested that future research should focus on improving cloud removal algorithms through the integration of machine learning,multi-source data fusion,and advanced remote sensing technologies.By expanding validation efforts and refining cloud removal strategies,more accurate and reliable snow products can be developed,contributing to enhanced snow monitoring and better management of water resources in alpine and arid areas.
基金supported by the National Natural Science Foundation of China(U2243238)the Program of the National Key Research and Development Plan(2023YFC3209304).
文摘Quantification of river flood risks is a prerequisite for floodplain management and development.The lower Yellow River(LYR)is characterized by a complex channel–floodplain system,which is prone to flooding but inhabits a large population on the floodplains.Many floodplain management modes have been presented,but implementation effects of these management modes have not been evaluated correctly.An integrated model was first proposed to evaluate the flood risks to people’s life and property,covering an improved module of two-dimensional(2D)morphodynamic processes and a module of flood risk evaluation for people,buildings and crops on the floodplains.Two simulation cases were then conducted to validate the model accuracy,including the hyperconcentrated flood event and dike-breach induced flood event occurring in the LYR.Finally,the integrated model was applied to key floodplains in the LYR,and the effects of different floodplain management modes were quantified on the risks to people’s life and property under an extreme flood event.Results indicate that:①Satisfactory accuracy was achieved in the simulation of these two flood events.The maximum sediment concentration was just underestimated by 9%,and the simulated inundation depth agreed well with the field record;②severe inundation was predicted to occur in most domains under the current topography(SchemeⅠ),which would be alleviated after implementing different floodplain management modes,with the area in slight inundation degree accounting for a large proportion under the mode of“construction of protection embankment”(SchemeⅡ)and the area in medium inundation degree occupying a high ratio under the mode of“floodplain partition harnessing”(SchemeⅢ);and③compared with SchemeⅠ,the high-risk area for people’s life and property would reduce by 21%–49%under SchemeⅡ,and by 35%–93%under SchemeⅢ.
基金supported by the National Key Technologies R&D Program of China during the 12th Five-Year Plan period(2015BAD01B02)the Special Program for Rice Scientific Research,Ministry of Agriculture,China(201603002-5-1)the Construction of Modern Agricultural and Industrial Technology System Project special fund,China(CARS01-47)
文摘In this study we report the results of a decade-long breeding program for japonica super rice made by Nanjing Branch of Chinese National Center for Rice Improvement in Jiangsu Academy of Agricultural Sciences. We concluded that selection of parents with good comprehensive traits and complementary advantages and disadvantages of both parents in the hybrid combination, and early selection of high heritability traits in earlier segregating generations could significantly improve the breeding efficiency. The use of closely-linked functional markers in pyramiding of multiple genes could greatly increase breeding efficiency, avoiding time-consuming and laborious steps that were used in traditional breeding program. It is also important to coordinate the yield components with variety characteristics such as yield stability, wide adaptability, lodging resistance, and an attractive grain appearance during late growth stage of rice.
基金Supported by the PetroChina Science and Technology Project(2022KT1205).
文摘The relationship between fracture calcite veins and shale gas enrichment in the deep Ordovician Wufeng Formation-Silurian Longmaxi Formation (Wufeng-Longmaxi) shales in southern Sichuan Basin was investigated through core and thin section observations, cathodoluminescence analysis, isotopic geochemistry analysis, fluid inclusion testing, and basin simulation. Tectonic fracture calcite veins mainly in the undulating part of the structure and non-tectonic fracture calcite veins are mainly formed in the gentle part of the structure. The latter, mainly induced by hydrocarbon generation, occurred at the stage of peak oil and gas generation, while the former turned up with the formation of Luzhou paleouplift during the Indosinian. Under the influence of hydrocarbon generation pressurization process, fractures were opened and closed frequently, and oil and gas episodic activities are recorded by veins. The formation pressure coefficient at the maximum paleodepth exceeds 2.0. The formation uplift stage after the Late Yanshanian is the key period for shale gas migration. Shale gas migrates along the bedding to the high part of the structure. The greater the structural fluctuation is, the more intense the shale gas migration activity is, and the loss is more. The gentler the formation is, the weaker the shale gas migration activity is, and the loss is less. The shale gas enrichment in the core of gentle anticlines and gentle synclines is relatively higher.
基金supported by the National Natural Science Foundation of China(Grant No.42122046,42076202)Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB42040402)+5 种基金National Natural Science Foundation of China(Grant No.42076202)National Key R&D Program of China(Grant No.2017YFA0603202)Key Deployment Project of Centre for Ocean Mega-Research of Science,CAS(Grant Nos.COMS2019Q01 and COMS2019Q07)NCAR is sponsored by the US National Science Foundationsupported by NASA Award 80NSSC17K0565the Regional and Global Model Analysis(RGMA)component of the Earth and Environmental System Modeling Program of the U.S.Department of Energy’s Office of Biological&Environmental Research(BER)via National Science Foundation IA 1844590。
文摘The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content(OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ(1 zetta J = 1021 J) using the IAP/CAS dataset and by16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Nino-Southern Oscillation(ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans,and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation.
基金supported by the National Key R&D Program of China (Grant No. 2017YFA0603202)the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB42040402)+4 种基金Key Deployment Project of Centre for Ocean Mega-Research of Science, CAS (Grant No. COMS2019Q01)sponsored by the US National Science Foundationsupported by NASA Award 80NSSC17K0565the Regional and Global Model Analysis (RGMA) component of the Earth and Environmental System Modeling Program of the U.S. Department of Energy's Office of Biological & Environmental Research (BER) via National Science Foundation IA 1844590partially supported by NOAA (grant NA14NES4320003 to CISESS-MD at the University of Maryland)。
文摘The long-term warming of the ocean is a critical indicator of both the past and present state of the climate system. It also provides insights about the changes to come, owing to the persistence of both decadal variations and secular trends,which the ocean records extremely well(Hansen et al., 2011;IPCC, 2013;Rhein et al., 2013;Trenberth et al., 2016;Abram et al., 2019).
文摘<b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:""><span style="font-family:Verdana;"> The aim of this study was to investigate whether magnetic resonance spectrum (MRS) and MR imaging features can be used for non-invasive medulloblastoma subgrouping, and analyse patient characteristics and prognosis of molecular subtypes of medulloblastoma. </span><b><span style="font-family:Verdana;">Material and Methods: </span></b><span style="font-family:Verdana;">32 patients with medulloblastoma underwent MRI prior to surgical resection, 16 of them underwent MRS. MR imaging features and metabolites measured by MRS were analysed to distinguish molecular subtypes of medulloblastoma. Patient demographics, histopathological types, and prognosis of different molecular subtypes were analysed and compared respectively. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">MRS and MR imaging features </span><span style="font-family:Verdana;">differed from different individuals, but without statistical significance that involves acquiring non-quantitative MR imaging features and NAA/Cr, Cho/Cr, Lip/Cr, Glu and Gln/Cr ratio, to be used to determine molecular subtypes. There was no significant difference of the three molecular subtypes in age, gender and pathological type. The 5-year event-free survival (EFS) of SHH, WNT and non SHH/WNT subtype respectively were 75%, 57.1%, 38.1%, with no significant difference (</span><i><span style="font-family:Verdana;">p</span></i><span style="font-family:Verdana;"> = 0.382). 5-year EFS of non SHH/WNT subtype was significantly higher in ≤3 years old group than >3 years old group (</span><i><span style="font-family:Verdana;">p </span></i><span style="font-family:Verdana;">= 0.047). </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> MRS and MR imaging features can’t be used to determine molecular subtypes based on our small sample study. There was no significant difference of the prognosis in the three molecular subtypes. The prognosis of ≤3 years old group of non SHH/WNT subtype is better than >3 years old group.
基金Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2022R281)Princess Nourah bint Abdulrahman University,Riyadh,SaudiArabia.The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code:(22UQU4331004DSR31).
文摘Applied linguistics means a wide range of actions which include addressing a few language-based problems or solving some language-based concerns.Emails stay in the leading positions for business as well as personal use.This popularity grabs the interest of individuals with malevolent inten-tions—phishing and spam email assaults.Email filtering mechanisms were developed incessantly to follow unwanted,malicious content advancement to protect the end-users.But prevailing solutions were focused on phishing email filtering and spam and whereas email labelling and analysis were not fully advanced.Thus,this study provides a solution related to email message body text automatic classification into phishing and email spam.This paper presents an Improved Fruitfly Optimization with Stacked Residual Recurrent Neural Network(IFFO-SRRNN)based on Applied Linguistics for Email Classification.The presented IFFO-SRRNN technique examines the intrinsic features of email for the identification of spam emails.At the preliminary level,the IFFO-SRRNN model follows the email pre-processing stage to make it compatible with further computation.Next,the SRRNN method can be useful in recognizing and classifying spam emails.As hyperparameters of the SRRNN model need to be effectually tuned,the IFFO algorithm can be utilized as a hyperparameter optimizer.To investigate the effectual email classification results of the IFFO-SRDL technique,a series of simulations were taken placed on public datasets,and the comparison outcomes highlight the enhancements of the IFFO-SRDL method over other recent approaches with an accuracy of 98.86%.
文摘Recently Zhang et al.(2024) published their study entitled “Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: A long-term follow-up pilot study.” The authors present three metachromatic leukodystrophy(MLD) patients treated with gene therapy and claim stabilization or even improvement, despite advanced symptomatic disease stage. The metachromatic leukodystrophy initiative(MLDi)(Schoenmakers et al., 2022), an international collaborative network and registry for MLD, urges caution in interpreting these results, as the evidence raises several critical concerns. These claims risk fostering false hope among MLD patients and their families, particularly given the significant gaps in the data provided(Fig. 1).
基金Athanasia Stoupa received a research grant from the European Society for Paediatric Endocrinology (ESPE). Aurore Carré, Dulanjalee Kariyawasam, and Michel Polak received funding from Sandoz SAS and Merck Serono France, the French Society of Endocrinology and Paediatric Diabetology (SFEDP), and the French National Research Agency (ANR-21-CE14-0055-01-MITHY-PLA) .
文摘Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and one of the most common preventable causes of intellectual disability in the world. CH may be due to developmental or functional thyroid defects (primary or peripheral CH) or be hypothalamic-pituitary in origin (central CH). In most cases, primary CH is caused by a developmental malformation of the gland (thyroid dysgenesis, TD) or by a defect in thyroid hormones synthesis (dyshormonogenesis, DH). TD represents about 65% of CH and a genetic cause is currently identified in fewer than 5% of patients. The remaining 35% are cases of DH and are explained with certainty at the molecular level in more than 50% of cases. The etiology of CH is mostly unknown and may include contributions from individual and environmental factors. In recent years, the detailed phenotypic description of patients, high-throughput sequencing technologies, and the use of animal models have made it possible to discover new genes involved in the development or function of the thyroid gland. This paper reviews all the genetic causes of CH. The modes by which CH is transmitted will also be discussed, including a new oligogenic model. CH is no longer simply a dominant disease for cases of CH due to TD and recessive for cases of CH due to DH, but a far more complex disorder.
基金supported by the National Key Research and Development Program of China(2018YFA0903200,2018YFA0903201,and 2020YFA0803502)the National Natural Science Foundation of China(81925037,U22A20371,31830021,32030036,and 82270055)+5 种基金the 111 Project(B16021,China)National High-level Personnel of Special Support Program(2017RA2259,China)Guangdong International Science and Technology Cooperation Base(2021A0505020015,China)Innovative and Research Teams Project of Guangdong Higher Education Institution(2021KCXTD001,China)Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y036,China)Guangdong Natural Science Funds for Distinguished Young Scholar(2021B1515020065,China)。
文摘Interleukin(IL)-17A,a pro-inflammatory cytokine,is a fundamental function in the onset and advancement of multiple immune diseases.To uncover the primary compounds with IL-17A inhibitory activity,a large-scale screening of the library of traditional Chinese medicine constituents and microbial secondary metabolites was conducted using splenic cells from IL-17A-GFP reporter mice cultured under Th17-priming conditions.Our results indicated that some aureane-type sesquiterpene tetraketides isolated from a wetland mud-derived fungus,Myrothecium gramineum,showed remarkable IL-17A inhibitory activity.Nine new aureane-type sesquiterpene tetraketides,myrogramins A-I(1,4-11),and two known ones(2 and 3)were isolated and identified from the strain.Compounds 1,3,4,10,and 11 exhibited significant IL-17A inhibitory activity.Among them,compound 3,with a high fermentation yield dosedependently inhibited the generation of IL-17A and suppressed glycolysis in splenic cells under Th17-priming conditions.Strikingly,compound 3 suppressed immunopathology in both IL-17A-mediated animal models of experimental autoimmune encephalomyelitis and pulmonary hypertension.Our results revealed that aureane-type sesquiterpene tetraketides are a novel class of immunomodulators with IL-17A inhibitory activity,and hold great promise applications in treating IL-17A-mediated immune diseases.
