The aim of this paper was to characterize through experiment the moisture and temperature kinetic behavior of Eucalyptus gomphocephala wood samples using microwave heating(MWH)in two scenarios:intermittently and conti...The aim of this paper was to characterize through experiment the moisture and temperature kinetic behavior of Eucalyptus gomphocephala wood samples using microwave heating(MWH)in two scenarios:intermittently and continuously.The mechanical properties and surface appearance of the heated samples were also investigated.Continuous and intermittent microwave drying kinetic experiments were conducted at a frequency of 2.45 GHz using a microwave laboratory oven at 300,500,and 1000 watts.Drying rate curves indicated three distinct phases of MWH.Increasing the microwave power with a shorter drying time led to rapid increases in internal temperature and water evaporation rates of the heated samples.Mechanical results indicated that samples heated under continuous MW(Microwave)power at 300 watts had a modulus of rupture(MOR)and modulus of elasticity(MOE)in three static bending tests higher than 29%and 36%,respectively,than samples heated at 1000 watts.Intermittent microwave heating(IMWH)of samples at 300 and 1000 watts produced the highest MOR and MOE values of 31%and 51%,respectively,unlike those heated under continuous microwave heating(CMWH).External qualitative observation showed that samples heated at high microwave power had severe surface checks.These defects were missing when using IMWH.An analysis of variance(ANOVA)showed that mechanical properties were linked to both microwave power level and the heating scenario,except for MOR in axial compression under CMWH.展开更多
This study investigates the long-term thermal-oxidative stability and mechanical properties of phenolcontaining phthalonitrile monomer(PN75)and dicyanate ester of bisphenol-A(DCBA)composites reinforced with short carb...This study investigates the long-term thermal-oxidative stability and mechanical properties of phenolcontaining phthalonitrile monomer(PN75)and dicyanate ester of bisphenol-A(DCBA)composites reinforced with short carbon fibers T700SC(SCF)within a temperature range of 330375℃.The research focuses on the PN75 monomer and DCBA blend reinforced SCF composites with varying SCF content,examining mass loss and changes in flexural strength after thermal aging for 50 h(h).Results show that the SCF-reinforced composites based on the PN75/DCBA blend consistently outperform the neat blend in flexural strength,both at room temperature and after thermal aging.The introduction of the SCF significantly improves the composites'thermal stability and mechanical retention,with higher SCF content correlating to better performance.Notably,after aging at 350℃,the SCF-reinforced composites based(30%(mass)SCF)retained 88.8%of its flexural strength,compared to 61.1%for the neat blend.Morphological analysis reveals that while thermal aging causes degradation of the PN75/DCBA blend layer on SCF surfaces,the overall composite structure maintains good mechanical properties up to 350℃.At 375℃,significant degradation occurs,yet the composites still retain flexural strengths above 78 MPa.This study demonstrates the potential of the SCF-reinforced composites based on PN75/DCBA blend for high-temperature applications,establishing their upper-temperature limit for long-term use in oxidative environments.展开更多
In this study,we simulated the thermal behavior of the mud-brick walls of a Nubian vault.We used EnergyPlus software for the simulation.The results obtained showed that the indoor temperature varies from 25.5℃ to 26....In this study,we simulated the thermal behavior of the mud-brick walls of a Nubian vault.We used EnergyPlus software for the simulation.The results obtained showed that the indoor temperature varies from 25.5℃ to 26.5℃ for the period of January 2018.It varies from 33.2℃ to 33.6℃ with an average value of 33.1℃ for the month of April 2018.For the period of July 2018,it varies from 30.3℃ to 32.2℃ with an average value of 31.2℃..Relative humidity for the period of July ranged from 62.3%to 73.5%,with an average value of 67.9%.The simulation enabled us to compare simulated and measured temperature and humidity values.We found that the level of thermal comfort in the Nubian vault is acceptable in both cool and hot periods.In view of these results,we can say that the Nubian vault is an architecture suited to our climate.The technical concept of the Nubian vault is adapted to the climatic conditions and traditional know-how of the Sahel.We also found that the use of raw earth,a locally available material,and the Nubian vault architectural process,contribute to thermal comfort and a reappropriation of local and adapted know-how.展开更多
BACKGROUND Glucocorticoids(GC)are the cornerstone in the treatment of severe alcoholassociated hepatitis(SAH)but may be associated with adverse events.CASE SUMMARY We report a prospective series of patients with SAH w...BACKGROUND Glucocorticoids(GC)are the cornerstone in the treatment of severe alcoholassociated hepatitis(SAH)but may be associated with adverse events.CASE SUMMARY We report a prospective series of patients with SAH who were treated with GC and developed de novo arthropathy within 2 weeks of GC cessation.Five patients were included in this series,three of whom were women.All patients underwent ultrasound evaluation and were referred to the Rheumatology Clinics.Final diagnoses were:Arthralgia associated with GC cessation(n=3),polymyalgia rheumatica(n=1)and psoriatic arthritis(n=1).Joint soreness was the main symptom,whereas arthritis occurred rarely.Patients with arthralgia associated with GC cessation required longer regimes of GC and tapering strategies but remained free of symptoms and specific treatment in the long term.CONCLUSION De novo arthropathy may occur following GC for SAH.Close monitoring and tapering regimes are advised.展开更多
This study addresses a challenge of parametrizing a resolution function of a neutron beam from the neutron time of flight facility n_TOF at CERN.A difficulty stems from a fact that a resolution function exhibits rathe...This study addresses a challenge of parametrizing a resolution function of a neutron beam from the neutron time of flight facility n_TOF at CERN.A difficulty stems from a fact that a resolution function exhibits rather strong variations in shape,over approximately ten orders of magnitude in neutron energy.To avoid a need for a manual identification of the appropri-ate analytical forms-hindering past attempts at its parametrization-we take advantage of the versatile machine learning techniques.Specifically,we parametrized it by training a multilayer feedforward neural network,relying on a key idea that such network acts as a universal approximator.The proof-of-concept is presented for a resolution function for the first experimental area of the n_TOF facility from the third phase of its operation.We propose an optimal network structure for a resolution function in question,which is also expected to be optimal or near-optimal for other experimental areas and for different phases of n_TOF operation.To reconstruct several resolution function forms in common use from a single para-metrized form,we provide a practical tool in the form of a specialized C++class encapsulating the computationally efficient procedures suited to the task.展开更多
We report the observation of Zeeman splitting in multiple spectral lines emitted by a laser-produced,magnetized plasma(1–3×10^(18)cm^(-3),1–15 eV)in the context of a laboratory astrophysics experiment under a c...We report the observation of Zeeman splitting in multiple spectral lines emitted by a laser-produced,magnetized plasma(1–3×10^(18)cm^(-3),1–15 eV)in the context of a laboratory astrophysics experiment under a controlled magneticfield up to 20T.Nitrogen lines(NII)in the visible range were used to diagnose the magneticfield and plasma conditions.This was performed by coupling our data with(563–574 nm)the Stark–Zeeman line-shape code PPPB.The excellent agreement between experiment and simulations paves the way for a non-intrusive experimental platform to get time-resolved measurements of the local magneticfield in laboratory plasmas.展开更多
AIM: To find the point mutations meaningful for inactivationof liver-related putative tumor suppressor gene (LPTS) gene,a human novel liver-related putative tumor suppressor geneand telomerase inhibitor in hepatocellu...AIM: To find the point mutations meaningful for inactivationof liver-related putative tumor suppressor gene (LPTS) gene,a human novel liver-related putative tumor suppressor geneand telomerase inhibitor in hepatocellular carcinoma.METHODS: The entire coding sequence of LPTS genewas examined for mutations by single strand conformationpolymorphism (SSCP) assay and PCR products directsequencing in 56 liver cancer cell lines, 7 ovarian cancerand 7 head & neck tumor cell lines and 70 pairs of HCCtissues samples. The cDNA fragment coding for the mostfrequent mutant protein was subcloned into GST fusionexpression vector. The product was expressed in E. coliand purified by glutathione-agarose column. Telomericrepeat amplification protocol (TRAP) assays wereperformed to study the effect of point mutation totelomerase inhibitory activity.RESULTS: SSCP gels showed the abnormal shifting bandsand DNA sequencing found that there were 5 differentmutations and/or polymorphisms in 12 tumor cell lineslocated at exon2, exon5 and exon7. The main alterationswere A(778)A/G and A(880)T in exon7. The change in siteof 778 could not be found in HCC tissue samples, while themutation in position 880 was seen in 7 (10 %) cases. Themutation in the site of 880 had no effect on telomeraseinhibitory activity.CONCLUSION: Alterations identified in this study arepolymorphisms of LPTS gene. LPTS mutations occur in HCCbut are infrequent and of little effect on the telomeraseinhibitory function of the protein. Epigenetics, such asmethylation, acetylation, may play the key role in inactivationof LPTS.展开更多
文摘The aim of this paper was to characterize through experiment the moisture and temperature kinetic behavior of Eucalyptus gomphocephala wood samples using microwave heating(MWH)in two scenarios:intermittently and continuously.The mechanical properties and surface appearance of the heated samples were also investigated.Continuous and intermittent microwave drying kinetic experiments were conducted at a frequency of 2.45 GHz using a microwave laboratory oven at 300,500,and 1000 watts.Drying rate curves indicated three distinct phases of MWH.Increasing the microwave power with a shorter drying time led to rapid increases in internal temperature and water evaporation rates of the heated samples.Mechanical results indicated that samples heated under continuous MW(Microwave)power at 300 watts had a modulus of rupture(MOR)and modulus of elasticity(MOE)in three static bending tests higher than 29%and 36%,respectively,than samples heated at 1000 watts.Intermittent microwave heating(IMWH)of samples at 300 and 1000 watts produced the highest MOR and MOE values of 31%and 51%,respectively,unlike those heated under continuous microwave heating(CMWH).External qualitative observation showed that samples heated at high microwave power had severe surface checks.These defects were missing when using IMWH.An analysis of variance(ANOVA)showed that mechanical properties were linked to both microwave power level and the heating scenario,except for MOR in axial compression under CMWH.
基金funded by the Innovative Research Group project of the National Natural Science Foundation of China(52373003).
文摘This study investigates the long-term thermal-oxidative stability and mechanical properties of phenolcontaining phthalonitrile monomer(PN75)and dicyanate ester of bisphenol-A(DCBA)composites reinforced with short carbon fibers T700SC(SCF)within a temperature range of 330375℃.The research focuses on the PN75 monomer and DCBA blend reinforced SCF composites with varying SCF content,examining mass loss and changes in flexural strength after thermal aging for 50 h(h).Results show that the SCF-reinforced composites based on the PN75/DCBA blend consistently outperform the neat blend in flexural strength,both at room temperature and after thermal aging.The introduction of the SCF significantly improves the composites'thermal stability and mechanical retention,with higher SCF content correlating to better performance.Notably,after aging at 350℃,the SCF-reinforced composites based(30%(mass)SCF)retained 88.8%of its flexural strength,compared to 61.1%for the neat blend.Morphological analysis reveals that while thermal aging causes degradation of the PN75/DCBA blend layer on SCF surfaces,the overall composite structure maintains good mechanical properties up to 350℃.At 375℃,significant degradation occurs,yet the composites still retain flexural strengths above 78 MPa.This study demonstrates the potential of the SCF-reinforced composites based on PN75/DCBA blend for high-temperature applications,establishing their upper-temperature limit for long-term use in oxidative environments.
文摘In this study,we simulated the thermal behavior of the mud-brick walls of a Nubian vault.We used EnergyPlus software for the simulation.The results obtained showed that the indoor temperature varies from 25.5℃ to 26.5℃ for the period of January 2018.It varies from 33.2℃ to 33.6℃ with an average value of 33.1℃ for the month of April 2018.For the period of July 2018,it varies from 30.3℃ to 32.2℃ with an average value of 31.2℃..Relative humidity for the period of July ranged from 62.3%to 73.5%,with an average value of 67.9%.The simulation enabled us to compare simulated and measured temperature and humidity values.We found that the level of thermal comfort in the Nubian vault is acceptable in both cool and hot periods.In view of these results,we can say that the Nubian vault is an architecture suited to our climate.The technical concept of the Nubian vault is adapted to the climatic conditions and traditional know-how of the Sahel.We also found that the use of raw earth,a locally available material,and the Nubian vault architectural process,contribute to thermal comfort and a reappropriation of local and adapted know-how.
基金Supported by the Instituto de Salud Carlos III,No.PI22/00910.
文摘BACKGROUND Glucocorticoids(GC)are the cornerstone in the treatment of severe alcoholassociated hepatitis(SAH)but may be associated with adverse events.CASE SUMMARY We report a prospective series of patients with SAH who were treated with GC and developed de novo arthropathy within 2 weeks of GC cessation.Five patients were included in this series,three of whom were women.All patients underwent ultrasound evaluation and were referred to the Rheumatology Clinics.Final diagnoses were:Arthralgia associated with GC cessation(n=3),polymyalgia rheumatica(n=1)and psoriatic arthritis(n=1).Joint soreness was the main symptom,whereas arthritis occurred rarely.Patients with arthralgia associated with GC cessation required longer regimes of GC and tapering strategies but remained free of symptoms and specific treatment in the long term.CONCLUSION De novo arthropathy may occur following GC for SAH.Close monitoring and tapering regimes are advised.
基金supported by the Croatian Science Foundation under the project number HRZZ-IP-2022-10-3878funding from the European Union’s Horizon Europe Research and Innovation programme under Grant Agreement No 101057511Funding Open access funding provided by CERN (European Organization for Nuclear Research).
文摘This study addresses a challenge of parametrizing a resolution function of a neutron beam from the neutron time of flight facility n_TOF at CERN.A difficulty stems from a fact that a resolution function exhibits rather strong variations in shape,over approximately ten orders of magnitude in neutron energy.To avoid a need for a manual identification of the appropri-ate analytical forms-hindering past attempts at its parametrization-we take advantage of the versatile machine learning techniques.Specifically,we parametrized it by training a multilayer feedforward neural network,relying on a key idea that such network acts as a universal approximator.The proof-of-concept is presented for a resolution function for the first experimental area of the n_TOF facility from the third phase of its operation.We propose an optimal network structure for a resolution function in question,which is also expected to be optimal or near-optimal for other experimental areas and for different phases of n_TOF operation.To reconstruct several resolution function forms in common use from a single para-metrized form,we provide a practical tool in the form of a specialized C++class encapsulating the computationally efficient procedures suited to the task.
基金supported by grants managed by l’Agence Nationale de la Recherche under the Investissements d’Avenir programs Grant Nos. ANR-18-EURE-0014, ANR-10-LABX-0039-PALM, and ANR-22-CE30-0044supported by grants from Japan Society for the Promotion of Science (JSPS) KAKENHI (Grant No. 23K20038)+2 种基金JSPS Core-to-Core program (Grant No. JPJSCCA20230003)carried out within the framework of the EUROfusion Consortium, funded by the European Union via the Euratom Research and Training Programme (Grant Agreement No. 101052200-EUROfusion)operated within the framework of the Enabling Research Project No. AWP24-ENR-IFE.02.CEA-01 “Magnetized ICF”
文摘We report the observation of Zeeman splitting in multiple spectral lines emitted by a laser-produced,magnetized plasma(1–3×10^(18)cm^(-3),1–15 eV)in the context of a laboratory astrophysics experiment under a controlled magneticfield up to 20T.Nitrogen lines(NII)in the visible range were used to diagnose the magneticfield and plasma conditions.This was performed by coupling our data with(563–574 nm)the Stark–Zeeman line-shape code PPPB.The excellent agreement between experiment and simulations paves the way for a non-intrusive experimental platform to get time-resolved measurements of the local magneticfield in laboratory plasmas.
基金a grant from National High Technology"863"Program of China,No.2001AA221021a grant from Special Funds for Major State Basic Research"973"of China,No.001CB510205+1 种基金a grant from the National Natural Sciences Foundation of China,No.30170524Chine-France PRA dans le domaine de la Biologie 2001.No.PRA B 01-05
文摘AIM: To find the point mutations meaningful for inactivationof liver-related putative tumor suppressor gene (LPTS) gene,a human novel liver-related putative tumor suppressor geneand telomerase inhibitor in hepatocellular carcinoma.METHODS: The entire coding sequence of LPTS genewas examined for mutations by single strand conformationpolymorphism (SSCP) assay and PCR products directsequencing in 56 liver cancer cell lines, 7 ovarian cancerand 7 head & neck tumor cell lines and 70 pairs of HCCtissues samples. The cDNA fragment coding for the mostfrequent mutant protein was subcloned into GST fusionexpression vector. The product was expressed in E. coliand purified by glutathione-agarose column. Telomericrepeat amplification protocol (TRAP) assays wereperformed to study the effect of point mutation totelomerase inhibitory activity.RESULTS: SSCP gels showed the abnormal shifting bandsand DNA sequencing found that there were 5 differentmutations and/or polymorphisms in 12 tumor cell lineslocated at exon2, exon5 and exon7. The main alterationswere A(778)A/G and A(880)T in exon7. The change in siteof 778 could not be found in HCC tissue samples, while themutation in position 880 was seen in 7 (10 %) cases. Themutation in the site of 880 had no effect on telomeraseinhibitory activity.CONCLUSION: Alterations identified in this study arepolymorphisms of LPTS gene. LPTS mutations occur in HCCbut are infrequent and of little effect on the telomeraseinhibitory function of the protein. Epigenetics, such asmethylation, acetylation, may play the key role in inactivationof LPTS.
