Separation bubbles forming on airfoils significantly influence aerodynamic behavior,particularly at low Reynolds numbers,making their accurate prediction a critical challenge in transition modelling.This study investi...Separation bubbles forming on airfoils significantly influence aerodynamic behavior,particularly at low Reynolds numbers,making their accurate prediction a critical challenge in transition modelling.This study investigates numerical modeling of a separation bubble and the effects of airfoil thickness and camber variation on the formation of the bubble dynamics at low Reynolds numbers.The numerical results were compared with the experimental results obtained from surface pressure distribution measurements,oil flow visualisation,and surface shear measurements to analyse the detailed flow behavior.The combination of pressure and flow visualisation techniques provided complementary insights,enabling a detailed characterisation of bubble formation.The results reveal that both the thickness and camber of the airfoil significantly influence the location,length,and stability of the bubble.At low Reynolds number flows(Re=0.5×10^(5)),particularly for highly cambered profiles,closer to the leading edge,separation and long bubbles were observed.As the Reynolds number increased,the separation point shifted to the leading edge,and reattachment became more likely.In numerical studies,transition models can accurately model the bubble initiation point;however,they often fail to model the bubble reattachment points accurately.This is due to the inadequacy of models that use empirical expressions for turbulence modelling,particularly in low Reynolds number flows,in their viscous modelling.In this study,it was concluded that transition onset terms,which specifically affect bubble formation,should be modified for more accurate modeling.展开更多
Neuromorphic devices have shown great potential in simulating the function of biological neurons due to their efficient parallel information processing and low energy consumption.MXene-Ti_(3)C_(2)T_(x),an emerging two...Neuromorphic devices have shown great potential in simulating the function of biological neurons due to their efficient parallel information processing and low energy consumption.MXene-Ti_(3)C_(2)T_(x),an emerging twodimensional material,stands out as an ideal candidate for fabricating neuromorphic devices.Its exceptional electrical performance and robust mechanical properties make it an ideal choice for this purpose.This review aims to uncover the advantages and properties of MXene-Ti_(3)C_(2)T_(x)in neuromorphic devices and to promote its further development.Firstly,we categorize several core physical mechanisms present in MXene-Ti_(3)C_(2)T_(x)neuromorphic devices and summarize in detail the reasons for their formation.Then,this work systematically summarizes and classifies advanced techniques for the three main optimization pathways of MXene-Ti_(3)C_(2)T_(x),such as doping engineering,interface engineering,and structural engineering.Significantly,this work highlights innovative applications of MXene-Ti_(3)C_(2)T_(x)neuromorphic devices in cutting-edge computing paradigms,particularly near-sensor computing and in-sensor computing.Finally,this review carefully compiles a table that integrates almost all research results involving MXene-Ti_(3)C_(2)T_(x)neuromorphic devices and discusses the challenges,development prospects,and feasibility of MXene-Ti_(3)C_(2)T_(x)-based neuromorphic devices in practical applications,aiming to lay a solid theoretical foundation and provide technical support for further exploration and application of MXene-Ti_(3)C_(2)T_(x)in the field of neuromorphic devices.展开更多
A novel active contour model is proposed, which incorporates local information distributions in a fuzzy energy function to effectively deal with the intensity inhomogeneity. Moreover, the proposed model is convex with...A novel active contour model is proposed, which incorporates local information distributions in a fuzzy energy function to effectively deal with the intensity inhomogeneity. Moreover, the proposed model is convex with respect to the variable which is used for extracting the contour. This makes the model independent on the initial condition and suitable for an automatic segmentation. Furthermore, the energy function is minimized in a computationally efficient way by calculating the fuzzy energy alterations directly. Experiments are carried out to prove the performance of the proposed model over some existing methods. The obtained results confirm the efficiency of the method.展开更多
This study presents a numerical investigation of shallow water wave dynamics with particular emphasis on the role of surface tension.In the absence of surface tension,shallow water waves are primarily driven by gravit...This study presents a numerical investigation of shallow water wave dynamics with particular emphasis on the role of surface tension.In the absence of surface tension,shallow water waves are primarily driven by gravity and are well described by the classical Boussinesq equation,which incorporates fourth-order dispersion.Under this framework,solitary and shock waves arise through the balance of nonlinearity and gravity-induced dispersion,producing waveforms whose propagation speed,amplitude,and width depend largely on depth and initial disturbance.The resulting dynamics are comparatively smoother,with solitary waves maintaining coherent structures and shock waves displaying gradual transitions.When surface tension is incorporated,however,the dynamics become significantly richer.Surface tension introduces additional sixth-order dispersive terms into the governing equation,extending the classical model to the sixth-order Boussinesq equation.This higher-order dispersion modifies the balance between nonlinearity and dispersion,leading to sharper solitary wave profiles,altered shock structures,and a stronger sensitivity of wave stability to parametric variations.Surface tension effects also change the scaling laws for wave amplitude and velocity,producing conditions where solitary waves can narrow while maintaining large amplitudes,or where shock fronts steepen more rapidly compared to the tension-free case.These differences highlight how capillary forces,though often neglected in macroscopic wave studies,play a fundamental role in shaping dynamics at smaller scales or in systems with strong fluid–interface interactions.The analysis in this work is carried out using the Laplace-Adomian Decomposition Method(LADM),chosen for its efficiency and accuracy in solving high-order nonlinear partial differential equations.The numerical scheme successfully recovers both solitary and shock wave solutions under the sixth-order model,with error analysis confirming remarkably low numerical deviations.These results underscore the robustness of the method while demonstrating the profound contrast between shallow water wave dynamics without and with surface tension.展开更多
This paper describes specific constraints of vision systems that are dedicated to be embedded in mobile robots. If PC-based hardware architecture is convenient in this field because of its versatility, flexibility, pe...This paper describes specific constraints of vision systems that are dedicated to be embedded in mobile robots. If PC-based hardware architecture is convenient in this field because of its versatility, flexibility, performance, and cost, current real-time operating systems are not completely adapted to long processing with varying duration, and it is often necessary to oversize the system to guarantee fail-safe functioning. Also, interactions with other robotic tasks having more priority are difficult to handle. To answer this problem, we have developed a dynamically reconfigurable vision processing system, based on the innovative features of Cleopatre real-time applicative layer concerning scheduling and fault tolerance. This framework allows to define emergency and optional tasks to ensure a minimal quality of service for the other subsystems of the robot, while allowing to adapt dynamically vision processing chain to an exceptional overlasting vision process or processor overload. Thus, it allows a better cohabitation of several subsystems in a single hardware, and to develop less expensive but safe systems, as they will be designed for the regular case and not rare exceptional ones. Finally, it brings a new way to think and develop vision systems, with pairs of complementary operators.展开更多
Sodium ion batteries and capacitors have demonstrated their potential applications for next-generation low-cost energy storage devices.These devices’s rate ability is determined by the fast sodium ion storage behavio...Sodium ion batteries and capacitors have demonstrated their potential applications for next-generation low-cost energy storage devices.These devices’s rate ability is determined by the fast sodium ion storage behavior in electrode materials.Herein,a defective TiO2@reduced graphene oxide(M-TiO2@rGO)self-supporting foam electrode is constructed via a facile MXene decomposition and graphene oxide self-assembling process.The employment of the MXene parent phase exhibits distinctive advantages,enabling defect engineering,nanoengineering,and fluorine-doped metal oxides.As a result,the M-TiO2@rGO electrode shows a pseudocapacitance-dominated hybrid sodium storage mechanism.The pseudocapacitance-dominated process leads to high capacity,remarkable rate ability,and superior cycling performance.Significantly,an M-TiO2@rGO//Na3 V2(PO4)3 sodium full cell and an M-TiO2@rGO//HPAC sodium ion capacitor are fabricated to demonstrate the promising application of M-TiO2@rGO.The sodium ion battery presents a capacity of 177.1 mAh g-1 at 500 mA g-1 and capacity retention of 74%after 200 cycles.The sodium ion capacitor delivers a maximum energy density of 101.2 Wh kg-1 and a maximum power density of 10,103.7 W kg-1.At 1.0 A g-1,it displays an energy retention of 84.7%after 10,000 cycles.展开更多
Hazards and disasters have always negative impacts on the way of life.Landslide is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout theworld.Th...Hazards and disasters have always negative impacts on the way of life.Landslide is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout theworld.The present study aimed to assess and compare the prediction efficiency of different models in landslide susceptibility in the Kysuca river basin,Slovakia.In this regard,the fuzzy decision-making trial and evaluation laboratory combining with the analytic network process(FDEMATEL-ANP),Naïve Bayes(NB)classifier,and random forest(RF)classifier were considered.Initially,a landslide inventory map was produced with 2000 landslide and nonlandslide points by randomly dividedwith a ratio of 70%:30%for training and testing,respectively.The geospatial database for assessing the landslide susceptibility was generated with the help of 16 landslide conditioning factors by allowing for topographical,hydrological,lithological,and land cover factors.The ReliefF methodwas considered for determining the significance of selected conditioning factors and inclusion in the model building.Consequently,the landslide susceptibility maps(LSMs)were generated using the FDEMATEL-ANP,Naïve Bayes(NB)classifier,and random forest(RF)classifier models.Finally,the area under curve(AUC)and different arithmetic evaluation were used for validating and comparing the results and models.The results revealed that random forest(RF)classifier is a promising and optimum model for landslide susceptibility in the study area with a very high value of area under curve(AUC=0.954),lower value of mean absolute error(MAE=0.1238)and root mean square error(RMSE=0.2555),and higher value of Kappa index(K=0.8435)and overall accuracy(OAC=92.2%).展开更多
Background:More efficacious,noninvasive screening methods are needed for advanced colorectal neoplasia.miR-92a is a reliable and reproducible biomarker for early colorectal cancer detection in stool samples.We compare...Background:More efficacious,noninvasive screening methods are needed for advanced colorectal neoplasia.miR-92a is a reliable and reproducible biomarker for early colorectal cancer detection in stool samples.We compared the diagnostic efficacies of miR-92a,immunochemical fecal occult blood testing(FIT),and their combination(FIT+miR-92a)in a prospective multicenter screening trial.Methods:Overall,16,240 participants aged 30-75 years were enrolled between April 1,2021,and December 31,2023.A total of 15,586 participants returned samples available for both FIT and miR-92a tests.All those with positive,and a random selection of those with negative screening tests were recommended to undergo colonoscopy.Follow-ups were performed until participants completed the colonoscopic examination.A total of 1401 screen-positive and 2079 randomly selected screen-negative individuals completed colonoscopies.Primary outcomes included sensitivity,number needed to screen(NNS),Youden index and receiver operating characteristic area under the curve(AUC)for advanced adenomas and colorectal cancer[advanced neoplasia(AN)]for each screening modality in the diagnostic performance analysis.Results:Colonoscopy was performed in 3480 individuals.The colonoscopy compliance rate was 47.8%for screen-positive individuals.The sensitivity of miR-92a vs.FIT for AN was 70.9%vs.54.3%(P<0.001),NNS was 24.7 vs.32.2(P=0.001),Youden index was 47.9%vs.35.0%(P<0.001),AUC was 0.74 vs.0.67(P=0.010).FIT+miR-92a had a sensitivity of 85.4%,an NNS of 20.5,a Youden index of 47.9%and an AUC of 0.74 for AN.Conclusions:For AN screening,miR-92a demonstrated better sensitivity,NNS,Youden index and AUC as compared with FIT.Compared with FIT,using miR-92a appears to be more efficient for population-based screening programs.Screening sensitivity for AN can be further enhanced if conditionally used in combination with FIT.Trial registration Chinese Clinical Trial Registration Number:ChiCTR2200065415.展开更多
This work presents and analyses a geostatistical methodology for spatial modelling of Soil Lime Requirements (SLR) considering punctual samples of Cation Exchange Capacity (CEC) and Base Saturation (BS) soil propertie...This work presents and analyses a geostatistical methodology for spatial modelling of Soil Lime Requirements (SLR) considering punctual samples of Cation Exchange Capacity (CEC) and Base Saturation (BS) soil properties. Geostatistical Sequential Indicator Simulation is used to draw realizations from the joint uncertainty distributions of the CEC and the BS input variables. The joint distributions are accomplished applying the Principal Component Analyses (PCA) approach. The Monte Carlo method for handling error propagations is used to obtain realization values of the SLR model which are considered to compute and store statistics from the output uncertainty model. From these statistics, it is obtained predictions and uncertainty maps that represent the spatial variation of the output variable and the propagated uncertainty respectively. Therefore, the prediction map of the output model is qualified with uncertainty information that should be used on decision making activities related to the planning and management of environmental phenomena. The proposed methodology for SLR modelling presented in this article is illustrated using CEC and BS input sample sets obtained in a farm located in Ponta Grossa city, Paraná state, Brazil.展开更多
Objective: The integrated method was investigated to measure Vm/Km of mouse liver glutathione S-transfer-ase (GST) activity on GSH and 7-Cl-4-nitrobenzofurazozan. Methods: Presetting concentration of one substrate twe...Objective: The integrated method was investigated to measure Vm/Km of mouse liver glutathione S-transfer-ase (GST) activity on GSH and 7-Cl-4-nitrobenzofurazozan. Methods: Presetting concentration of one substrate twenty-fold above the other's and taking maximum product absorbance Am as parameter while Km as constant, Vm/Km was obtained by nonlinear fitting of GST reaction curve to the integrated Michaelis-Menten equation In [Am/(Am -Ai)] + Ai/ ( ξ× Km ) = ( Vm/Km )×ti (1). Results: Vm/Km for GST showed slight dependence on initial substrate concentration and data range, but it was resistant to background absorbance, error in reaction origin and small deviation in presetting Km. Vm/Km was proportional to the amount of GST with upper limit higher than that by initial rate. There was close correlation between Vm/Km and initial rate of the same GST. Consistent results were obtained by this integrated method and classical initial rate method for the measurement of mouse liver GST. Conclusion: With the concentration of one substrate twenty-fold above the other's, this integrated method was reliable to measure the activity of enzyme on two substrates , and substrate concentration of the lower one close to its apparent Km was able to be used.展开更多
BACKGROUND Dyskeratosis congenita is a rare disease characterized by bone marrow failure and a clinical triad of oral leukoplakia,nail dystrophy,and abnormal skin pigmentation.The genetics of dyskeratosis congenita in...BACKGROUND Dyskeratosis congenita is a rare disease characterized by bone marrow failure and a clinical triad of oral leukoplakia,nail dystrophy,and abnormal skin pigmentation.The genetics of dyskeratosis congenita include mutations in genes involved in telomere maintenance,including TINF2.CASE SUMMARY Here,we report a female patient who presented thrombocytopenia,anemia,reticulate hyperpigmentation,dystrophy in fingernails and toenails,and leukoplakia on the tongue.A histopathological study of the skin showed dyskeratocytes;however,a bone marrow biopsy revealed normal cell morphology.The patient was diagnosed with dyskeratosis congenita,but her family history did not reveal significant antecedents.Whole-exome sequencing showed a novel heterozygous punctual mutation in exon 6 from the TINF2 gene,namely,NM_001099274.1:-c.854delp.(Val285-Alafs*32).An analysis of telomere length showed short telomeres relative to the patient’s age.CONCLUSION The disease in this patient was caused by a germline novel mutation of TINF2 in one of her parents.展开更多
The grassland in the Hindu Kush Himalayan(HKH) region is one of the large st and most biodiverse mountain grassland types in the world,and its ecosystem service functions have profound impacts on the sustainable devel...The grassland in the Hindu Kush Himalayan(HKH) region is one of the large st and most biodiverse mountain grassland types in the world,and its ecosystem service functions have profound impacts on the sustainable development of the HKH region.Monitoring the spatiotemporal distribution of grassland aboveground biomass(AGB) accurately and quantifying its response to climate change are indispensable sources of information for sustainably managing grassland ecosystems in the HKH region.In this study,a pure vegetation index model(PVIM) was applied to estimate the long-term dynamics of grassland AGB in the HKH region during 2000-2018.We further quantified the response of grassland AGB to climate change(temperature and precipitation) by partial correlation and variance partitioning analyses and then compared their differences with elevation.Our results demonstrated that the grassland AGB predicted by the PVIM had a good linear relationship with the ground sampling data.The grassland AGB distribution pattern showed a decreasing trend from east to west across the HKH region except in the southern Himalayas.From 2000 to 2018,the mean AGB of the HKH region increased at a rate of 1.57 g/(m~2·yr) and ranged from 252.9(2000) to 307.8 g/m~2(2018).AGB had a positive correlation with precipitation in more than 80% of the grassland,and temperature was positively correlated with AGB in approximately half of the region.The change in grassland AGB was more responsive to the cumulative effect of annual precipitation,while it was more sensitive to the change in temperature in the growing season;in addition,the influence of climate varied at different elevations.Moreover,compared with that of temperature,the contribution of precipitation to grassland AGB change was greater in approximately 60% of the grassland,but the differences in the contribution for each climate factor were small between the two temporal scales at elevations over 2000 m.An accurate assessment of the temporal and spatial distributions of grassland AGB and the quantification of its response to climate change are of great significance for grassland management and sustainable development in the HKH region.展开更多
The recent systematic review and meta-analysis provided a comprehensive focus on the current state of cardiac resynchronization therapy(CRT).The authors determined the feasibility of physiological left bundle branch a...The recent systematic review and meta-analysis provided a comprehensive focus on the current state of cardiac resynchronization therapy(CRT).The authors determined the feasibility of physiological left bundle branch area pacing(LBBAP)in patients indicated for CRT through a careful analysis of trials.They found that LBBAP was associated with significant reductions in QRS duration,New York Heart Association functional class,B-type natriuretic peptide levels,and pacing thresholds as well as improvements in echocardiographic parameters compared to biventricular pacing.展开更多
The strongly anisotropic mechanical behaviors commonly observed in Zr-4 sheets typically lead to inferior formability.In this study,the mechanical behavior and texture evolution of a cold-rolled Zr-4 sheet under uniax...The strongly anisotropic mechanical behaviors commonly observed in Zr-4 sheets typically lead to inferior formability.In this study,the mechanical behavior and texture evolution of a cold-rolled Zr-4 sheet under uniaxial tension in various directions were systematically investigated,and the results showed both anisotropic yielding and hardening behavior in the Zr-4 sheet.The microstructure and texture features revealed by electron backscattered diffraction(EBSD)method indicate that this anisotropic mechanical behavior is closely related to the initial texture and its evolution during plastic deformation.In conjunction with experimental observations,a visco-plastic self-consistent(VPSC)model was employed to quantitatively analyze the relationship between the mechanical anisotropy and the texture features and activation of deformation modes.It was found that the yield anisotropy is affected by the distinct activity of prismaticslip,while the different activities of basalslip and extension twinning(ETW)result in anisotropic hardening.The distinct activation of deformation modes is mainly caused by differences in the evolution of the Schmid factor(SF)and critical resolved shear stress(CRSS)with increasing strain.Additionally,the results prove that the limited twinning activation with a fraction of less than 3%plays a non-negligible role in the hardening behavior during tension along the transverse direction.The latent hardening effect caused by the interaction between prismatic slip and tensile twinning is considered to successfully capture the anisotropic hardening behavior of the Zr-4 sheet.The implementation and insights from the predictions are presented and discussed in this work.展开更多
A new probability function of mining overlying strata and subsidence is put forward that has a general statistical significance based on the ideal stochastic medium displacement model. It establishes a new system of p...A new probability function of mining overlying strata and subsidence is put forward that has a general statistical significance based on the ideal stochastic medium displacement model. It establishes a new system of prediction on horizontal mining subsidence and deformation, which gives a new method for prediction on mining subsidence and deformation.展开更多
The Desierto de los Leones National Park is a place that features recreational activities for residents and visitors to Mexico City. The Presa de los Patos (Ducks Dam) is one of the many bodies of water that are prese...The Desierto de los Leones National Park is a place that features recreational activities for residents and visitors to Mexico City. The Presa de los Patos (Ducks Dam) is one of the many bodies of water that are present in the park. By means of physico-chemical and microbiological analysis, it was determined that the water of the Presa de los Patos cannot be considered potable. The pH range was between 5.5 - 5.9. The turbidity exceeded the values established in the standards (10.7 - 32.3 Nephelometric Turbidity Units (NTU’s)). Chemical Oxygen Demand (COD) showed that large amounts of oxygen are needed to oxidize organic matter (106 - 450 mg/L). The amount of coliforms and fecal coliforms exceeds the values established by the standards used (total coliforms 98 - 956 Colony Forming Units (CFU’s), fecal coliforms 78 - 807 CFU’s). Five bacterial genera (Escherichia coli, Pseudomona, Klebsiella, Shigella and Salmonella) were isolated and identified. Most of the bacteria isolated were resistant to ampicillin (90%), while 25% were resistant to ciprofloxacin. The water consumption of the Presa de los Patos is a great risk for the habitants and visitors of the park.展开更多
基金the Scientific and Technological Research Council of Turkey(TÜB˙ITAK)for support under project number:122M826to the Scientific Research Projects Unit of Erciyes University under contract No.:FYL-2023-13162 and FYL-2024-13701.
文摘Separation bubbles forming on airfoils significantly influence aerodynamic behavior,particularly at low Reynolds numbers,making their accurate prediction a critical challenge in transition modelling.This study investigates numerical modeling of a separation bubble and the effects of airfoil thickness and camber variation on the formation of the bubble dynamics at low Reynolds numbers.The numerical results were compared with the experimental results obtained from surface pressure distribution measurements,oil flow visualisation,and surface shear measurements to analyse the detailed flow behavior.The combination of pressure and flow visualisation techniques provided complementary insights,enabling a detailed characterisation of bubble formation.The results reveal that both the thickness and camber of the airfoil significantly influence the location,length,and stability of the bubble.At low Reynolds number flows(Re=0.5×10^(5)),particularly for highly cambered profiles,closer to the leading edge,separation and long bubbles were observed.As the Reynolds number increased,the separation point shifted to the leading edge,and reattachment became more likely.In numerical studies,transition models can accurately model the bubble initiation point;however,they often fail to model the bubble reattachment points accurately.This is due to the inadequacy of models that use empirical expressions for turbulence modelling,particularly in low Reynolds number flows,in their viscous modelling.In this study,it was concluded that transition onset terms,which specifically affect bubble formation,should be modified for more accurate modeling.
基金supported by the National Science Foundation for Distinguished Young Scholars of China(Grant No.12425209)the National Natural Science Foundation of China(Grant No.U20A20390,11827803,12172034,11822201,62004056,62104058,62271269).
文摘Neuromorphic devices have shown great potential in simulating the function of biological neurons due to their efficient parallel information processing and low energy consumption.MXene-Ti_(3)C_(2)T_(x),an emerging twodimensional material,stands out as an ideal candidate for fabricating neuromorphic devices.Its exceptional electrical performance and robust mechanical properties make it an ideal choice for this purpose.This review aims to uncover the advantages and properties of MXene-Ti_(3)C_(2)T_(x)in neuromorphic devices and to promote its further development.Firstly,we categorize several core physical mechanisms present in MXene-Ti_(3)C_(2)T_(x)neuromorphic devices and summarize in detail the reasons for their formation.Then,this work systematically summarizes and classifies advanced techniques for the three main optimization pathways of MXene-Ti_(3)C_(2)T_(x),such as doping engineering,interface engineering,and structural engineering.Significantly,this work highlights innovative applications of MXene-Ti_(3)C_(2)T_(x)neuromorphic devices in cutting-edge computing paradigms,particularly near-sensor computing and in-sensor computing.Finally,this review carefully compiles a table that integrates almost all research results involving MXene-Ti_(3)C_(2)T_(x)neuromorphic devices and discusses the challenges,development prospects,and feasibility of MXene-Ti_(3)C_(2)T_(x)-based neuromorphic devices in practical applications,aiming to lay a solid theoretical foundation and provide technical support for further exploration and application of MXene-Ti_(3)C_(2)T_(x)in the field of neuromorphic devices.
文摘A novel active contour model is proposed, which incorporates local information distributions in a fuzzy energy function to effectively deal with the intensity inhomogeneity. Moreover, the proposed model is convex with respect to the variable which is used for extracting the contour. This makes the model independent on the initial condition and suitable for an automatic segmentation. Furthermore, the energy function is minimized in a computationally efficient way by calculating the fuzzy energy alterations directly. Experiments are carried out to prove the performance of the proposed model over some existing methods. The obtained results confirm the efficiency of the method.
文摘This study presents a numerical investigation of shallow water wave dynamics with particular emphasis on the role of surface tension.In the absence of surface tension,shallow water waves are primarily driven by gravity and are well described by the classical Boussinesq equation,which incorporates fourth-order dispersion.Under this framework,solitary and shock waves arise through the balance of nonlinearity and gravity-induced dispersion,producing waveforms whose propagation speed,amplitude,and width depend largely on depth and initial disturbance.The resulting dynamics are comparatively smoother,with solitary waves maintaining coherent structures and shock waves displaying gradual transitions.When surface tension is incorporated,however,the dynamics become significantly richer.Surface tension introduces additional sixth-order dispersive terms into the governing equation,extending the classical model to the sixth-order Boussinesq equation.This higher-order dispersion modifies the balance between nonlinearity and dispersion,leading to sharper solitary wave profiles,altered shock structures,and a stronger sensitivity of wave stability to parametric variations.Surface tension effects also change the scaling laws for wave amplitude and velocity,producing conditions where solitary waves can narrow while maintaining large amplitudes,or where shock fronts steepen more rapidly compared to the tension-free case.These differences highlight how capillary forces,though often neglected in macroscopic wave studies,play a fundamental role in shaping dynamics at smaller scales or in systems with strong fluid–interface interactions.The analysis in this work is carried out using the Laplace-Adomian Decomposition Method(LADM),chosen for its efficiency and accuracy in solving high-order nonlinear partial differential equations.The numerical scheme successfully recovers both solitary and shock wave solutions under the sixth-order model,with error analysis confirming remarkably low numerical deviations.These results underscore the robustness of the method while demonstrating the profound contrast between shallow water wave dynamics without and with surface tension.
基金This work was supported by the French research office(No.01 K 0742)under the Cléopatre project.
文摘This paper describes specific constraints of vision systems that are dedicated to be embedded in mobile robots. If PC-based hardware architecture is convenient in this field because of its versatility, flexibility, performance, and cost, current real-time operating systems are not completely adapted to long processing with varying duration, and it is often necessary to oversize the system to guarantee fail-safe functioning. Also, interactions with other robotic tasks having more priority are difficult to handle. To answer this problem, we have developed a dynamically reconfigurable vision processing system, based on the innovative features of Cleopatre real-time applicative layer concerning scheduling and fault tolerance. This framework allows to define emergency and optional tasks to ensure a minimal quality of service for the other subsystems of the robot, while allowing to adapt dynamically vision processing chain to an exceptional overlasting vision process or processor overload. Thus, it allows a better cohabitation of several subsystems in a single hardware, and to develop less expensive but safe systems, as they will be designed for the regular case and not rare exceptional ones. Finally, it brings a new way to think and develop vision systems, with pairs of complementary operators.
基金supported by the National Natural Science Foundation of China(51702063,51672056)Natural Science Foundation of Heilongjiang(LC2018004)+1 种基金China Postdoctoral Science Foundation(2018M630340,2019T120254)the Fundamental Research Funds for the Central University。
文摘Sodium ion batteries and capacitors have demonstrated their potential applications for next-generation low-cost energy storage devices.These devices’s rate ability is determined by the fast sodium ion storage behavior in electrode materials.Herein,a defective TiO2@reduced graphene oxide(M-TiO2@rGO)self-supporting foam electrode is constructed via a facile MXene decomposition and graphene oxide self-assembling process.The employment of the MXene parent phase exhibits distinctive advantages,enabling defect engineering,nanoengineering,and fluorine-doped metal oxides.As a result,the M-TiO2@rGO electrode shows a pseudocapacitance-dominated hybrid sodium storage mechanism.The pseudocapacitance-dominated process leads to high capacity,remarkable rate ability,and superior cycling performance.Significantly,an M-TiO2@rGO//Na3 V2(PO4)3 sodium full cell and an M-TiO2@rGO//HPAC sodium ion capacitor are fabricated to demonstrate the promising application of M-TiO2@rGO.The sodium ion battery presents a capacity of 177.1 mAh g-1 at 500 mA g-1 and capacity retention of 74%after 200 cycles.The sodium ion capacitor delivers a maximum energy density of 101.2 Wh kg-1 and a maximum power density of 10,103.7 W kg-1.At 1.0 A g-1,it displays an energy retention of 84.7%after 10,000 cycles.
文摘Hazards and disasters have always negative impacts on the way of life.Landslide is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout theworld.The present study aimed to assess and compare the prediction efficiency of different models in landslide susceptibility in the Kysuca river basin,Slovakia.In this regard,the fuzzy decision-making trial and evaluation laboratory combining with the analytic network process(FDEMATEL-ANP),Naïve Bayes(NB)classifier,and random forest(RF)classifier were considered.Initially,a landslide inventory map was produced with 2000 landslide and nonlandslide points by randomly dividedwith a ratio of 70%:30%for training and testing,respectively.The geospatial database for assessing the landslide susceptibility was generated with the help of 16 landslide conditioning factors by allowing for topographical,hydrological,lithological,and land cover factors.The ReliefF methodwas considered for determining the significance of selected conditioning factors and inclusion in the model building.Consequently,the landslide susceptibility maps(LSMs)were generated using the FDEMATEL-ANP,Naïve Bayes(NB)classifier,and random forest(RF)classifier models.Finally,the area under curve(AUC)and different arithmetic evaluation were used for validating and comparing the results and models.The results revealed that random forest(RF)classifier is a promising and optimum model for landslide susceptibility in the study area with a very high value of area under curve(AUC=0.954),lower value of mean absolute error(MAE=0.1238)and root mean square error(RMSE=0.2555),and higher value of Kappa index(K=0.8435)and overall accuracy(OAC=92.2%).
基金supported by the Capital’s Funds for Health Improvement and Research(2024-1G-4023)the National Natural Science Foundation of China(82273721).
文摘Background:More efficacious,noninvasive screening methods are needed for advanced colorectal neoplasia.miR-92a is a reliable and reproducible biomarker for early colorectal cancer detection in stool samples.We compared the diagnostic efficacies of miR-92a,immunochemical fecal occult blood testing(FIT),and their combination(FIT+miR-92a)in a prospective multicenter screening trial.Methods:Overall,16,240 participants aged 30-75 years were enrolled between April 1,2021,and December 31,2023.A total of 15,586 participants returned samples available for both FIT and miR-92a tests.All those with positive,and a random selection of those with negative screening tests were recommended to undergo colonoscopy.Follow-ups were performed until participants completed the colonoscopic examination.A total of 1401 screen-positive and 2079 randomly selected screen-negative individuals completed colonoscopies.Primary outcomes included sensitivity,number needed to screen(NNS),Youden index and receiver operating characteristic area under the curve(AUC)for advanced adenomas and colorectal cancer[advanced neoplasia(AN)]for each screening modality in the diagnostic performance analysis.Results:Colonoscopy was performed in 3480 individuals.The colonoscopy compliance rate was 47.8%for screen-positive individuals.The sensitivity of miR-92a vs.FIT for AN was 70.9%vs.54.3%(P<0.001),NNS was 24.7 vs.32.2(P=0.001),Youden index was 47.9%vs.35.0%(P<0.001),AUC was 0.74 vs.0.67(P=0.010).FIT+miR-92a had a sensitivity of 85.4%,an NNS of 20.5,a Youden index of 47.9%and an AUC of 0.74 for AN.Conclusions:For AN screening,miR-92a demonstrated better sensitivity,NNS,Youden index and AUC as compared with FIT.Compared with FIT,using miR-92a appears to be more efficient for population-based screening programs.Screening sensitivity for AN can be further enhanced if conditionally used in combination with FIT.Trial registration Chinese Clinical Trial Registration Number:ChiCTR2200065415.
文摘This work presents and analyses a geostatistical methodology for spatial modelling of Soil Lime Requirements (SLR) considering punctual samples of Cation Exchange Capacity (CEC) and Base Saturation (BS) soil properties. Geostatistical Sequential Indicator Simulation is used to draw realizations from the joint uncertainty distributions of the CEC and the BS input variables. The joint distributions are accomplished applying the Principal Component Analyses (PCA) approach. The Monte Carlo method for handling error propagations is used to obtain realization values of the SLR model which are considered to compute and store statistics from the output uncertainty model. From these statistics, it is obtained predictions and uncertainty maps that represent the spatial variation of the output variable and the propagated uncertainty respectively. Therefore, the prediction map of the output model is qualified with uncertainty information that should be used on decision making activities related to the planning and management of environmental phenomena. The proposed methodology for SLR modelling presented in this article is illustrated using CEC and BS input sample sets obtained in a farm located in Ponta Grossa city, Paraná state, Brazil.
基金National Natural Science Foundation of China (No.30200266)
文摘Objective: The integrated method was investigated to measure Vm/Km of mouse liver glutathione S-transfer-ase (GST) activity on GSH and 7-Cl-4-nitrobenzofurazozan. Methods: Presetting concentration of one substrate twenty-fold above the other's and taking maximum product absorbance Am as parameter while Km as constant, Vm/Km was obtained by nonlinear fitting of GST reaction curve to the integrated Michaelis-Menten equation In [Am/(Am -Ai)] + Ai/ ( ξ× Km ) = ( Vm/Km )×ti (1). Results: Vm/Km for GST showed slight dependence on initial substrate concentration and data range, but it was resistant to background absorbance, error in reaction origin and small deviation in presetting Km. Vm/Km was proportional to the amount of GST with upper limit higher than that by initial rate. There was close correlation between Vm/Km and initial rate of the same GST. Consistent results were obtained by this integrated method and classical initial rate method for the measurement of mouse liver GST. Conclusion: With the concentration of one substrate twenty-fold above the other's, this integrated method was reliable to measure the activity of enzyme on two substrates , and substrate concentration of the lower one close to its apparent Km was able to be used.
文摘BACKGROUND Dyskeratosis congenita is a rare disease characterized by bone marrow failure and a clinical triad of oral leukoplakia,nail dystrophy,and abnormal skin pigmentation.The genetics of dyskeratosis congenita include mutations in genes involved in telomere maintenance,including TINF2.CASE SUMMARY Here,we report a female patient who presented thrombocytopenia,anemia,reticulate hyperpigmentation,dystrophy in fingernails and toenails,and leukoplakia on the tongue.A histopathological study of the skin showed dyskeratocytes;however,a bone marrow biopsy revealed normal cell morphology.The patient was diagnosed with dyskeratosis congenita,but her family history did not reveal significant antecedents.Whole-exome sequencing showed a novel heterozygous punctual mutation in exon 6 from the TINF2 gene,namely,NM_001099274.1:-c.854delp.(Val285-Alafs*32).An analysis of telomere length showed short telomeres relative to the patient’s age.CONCLUSION The disease in this patient was caused by a germline novel mutation of TINF2 in one of her parents.
基金Under the auspices of the Strategic Priority Research Program of the Chinese Academy of Sciences (No.XDA19030202)National Key Research and Development Program of China (No. 2020YFE0200800)+1 种基金International Cooperation and Exchange of National Natural Science Foundation of China (No. 31761143018)National Natural Science Foundation of China (No.42071344)。
文摘The grassland in the Hindu Kush Himalayan(HKH) region is one of the large st and most biodiverse mountain grassland types in the world,and its ecosystem service functions have profound impacts on the sustainable development of the HKH region.Monitoring the spatiotemporal distribution of grassland aboveground biomass(AGB) accurately and quantifying its response to climate change are indispensable sources of information for sustainably managing grassland ecosystems in the HKH region.In this study,a pure vegetation index model(PVIM) was applied to estimate the long-term dynamics of grassland AGB in the HKH region during 2000-2018.We further quantified the response of grassland AGB to climate change(temperature and precipitation) by partial correlation and variance partitioning analyses and then compared their differences with elevation.Our results demonstrated that the grassland AGB predicted by the PVIM had a good linear relationship with the ground sampling data.The grassland AGB distribution pattern showed a decreasing trend from east to west across the HKH region except in the southern Himalayas.From 2000 to 2018,the mean AGB of the HKH region increased at a rate of 1.57 g/(m~2·yr) and ranged from 252.9(2000) to 307.8 g/m~2(2018).AGB had a positive correlation with precipitation in more than 80% of the grassland,and temperature was positively correlated with AGB in approximately half of the region.The change in grassland AGB was more responsive to the cumulative effect of annual precipitation,while it was more sensitive to the change in temperature in the growing season;in addition,the influence of climate varied at different elevations.Moreover,compared with that of temperature,the contribution of precipitation to grassland AGB change was greater in approximately 60% of the grassland,but the differences in the contribution for each climate factor were small between the two temporal scales at elevations over 2000 m.An accurate assessment of the temporal and spatial distributions of grassland AGB and the quantification of its response to climate change are of great significance for grassland management and sustainable development in the HKH region.
文摘The recent systematic review and meta-analysis provided a comprehensive focus on the current state of cardiac resynchronization therapy(CRT).The authors determined the feasibility of physiological left bundle branch area pacing(LBBAP)in patients indicated for CRT through a careful analysis of trials.They found that LBBAP was associated with significant reductions in QRS duration,New York Heart Association functional class,B-type natriuretic peptide levels,and pacing thresholds as well as improvements in echocardiographic parameters compared to biventricular pacing.
基金financially supported by the National Major Science and Technology Projects of China(No.2019ZX06002001)the National Natural Science Foundation of China(No.52105413)the supports from Institute of Metal Research,Chinese Academy of Sciences(No.E055A501)。
文摘The strongly anisotropic mechanical behaviors commonly observed in Zr-4 sheets typically lead to inferior formability.In this study,the mechanical behavior and texture evolution of a cold-rolled Zr-4 sheet under uniaxial tension in various directions were systematically investigated,and the results showed both anisotropic yielding and hardening behavior in the Zr-4 sheet.The microstructure and texture features revealed by electron backscattered diffraction(EBSD)method indicate that this anisotropic mechanical behavior is closely related to the initial texture and its evolution during plastic deformation.In conjunction with experimental observations,a visco-plastic self-consistent(VPSC)model was employed to quantitatively analyze the relationship between the mechanical anisotropy and the texture features and activation of deformation modes.It was found that the yield anisotropy is affected by the distinct activity of prismaticslip,while the different activities of basalslip and extension twinning(ETW)result in anisotropic hardening.The distinct activation of deformation modes is mainly caused by differences in the evolution of the Schmid factor(SF)and critical resolved shear stress(CRSS)with increasing strain.Additionally,the results prove that the limited twinning activation with a fraction of less than 3%plays a non-negligible role in the hardening behavior during tension along the transverse direction.The latent hardening effect caused by the interaction between prismatic slip and tensile twinning is considered to successfully capture the anisotropic hardening behavior of the Zr-4 sheet.The implementation and insights from the predictions are presented and discussed in this work.
文摘A new probability function of mining overlying strata and subsidence is put forward that has a general statistical significance based on the ideal stochastic medium displacement model. It establishes a new system of prediction on horizontal mining subsidence and deformation, which gives a new method for prediction on mining subsidence and deformation.
文摘The Desierto de los Leones National Park is a place that features recreational activities for residents and visitors to Mexico City. The Presa de los Patos (Ducks Dam) is one of the many bodies of water that are present in the park. By means of physico-chemical and microbiological analysis, it was determined that the water of the Presa de los Patos cannot be considered potable. The pH range was between 5.5 - 5.9. The turbidity exceeded the values established in the standards (10.7 - 32.3 Nephelometric Turbidity Units (NTU’s)). Chemical Oxygen Demand (COD) showed that large amounts of oxygen are needed to oxidize organic matter (106 - 450 mg/L). The amount of coliforms and fecal coliforms exceeds the values established by the standards used (total coliforms 98 - 956 Colony Forming Units (CFU’s), fecal coliforms 78 - 807 CFU’s). Five bacterial genera (Escherichia coli, Pseudomona, Klebsiella, Shigella and Salmonella) were isolated and identified. Most of the bacteria isolated were resistant to ampicillin (90%), while 25% were resistant to ciprofloxacin. The water consumption of the Presa de los Patos is a great risk for the habitants and visitors of the park.
