An improved meshfree moving-Kriging(MK)formulation for free vibration analysis of functionally graded material-functionally graded carbon nanotube-reinforced composite(FGM-FGCNTRC)sandwich shells is first proposed in ...An improved meshfree moving-Kriging(MK)formulation for free vibration analysis of functionally graded material-functionally graded carbon nanotube-reinforced composite(FGM-FGCNTRC)sandwich shells is first proposed in this article.The proposed sandwich structure consists of skins of FGM layers and an FGCNTRC core.This structure possesses all the advantages of FGM and FGCNTRC,including high electrical or thermal insulating properties,high fatigue resistance,good corrosion resistance,high stiffness,low density,high strength,and high aspect ratios.Such sandwich structures can be used to replace conventional FGM structures.The present formulation has been established by using an improved meshfree MK method and the first-order shear deformation shell theory(FSDT).The effective material characteristics of the FGM-skin layers and the FGCNTRC core were calculated using the rule of mixture.Key parameters and factors such as the thickness-to-radius ratio,the length-to-radius ratio,layer-thickness ratios,CNT distributions,the volume fraction of CNTs,the power-law index,and various boundary conditions were rigorously investigated.A nonlinear CNT distribution that we term FG-nX is first proposed in this work,and many new results of FGM-FGCNTRC sandwich shells have been provided.展开更多
Objective:To determine the morphological characteristics of variations in populations of female adult sand fly,Sergentomyia anodontis Quate and Fairchild,1961 in caves in southern Thailand using morphometric analysis....Objective:To determine the morphological characteristics of variations in populations of female adult sand fly,Sergentomyia anodontis Quate and Fairchild,1961 in caves in southern Thailand using morphometric analysis.Methods:A total of 107 female Sergentomyia anodontis were isolated from 651 sand flies captured by CDC light traps overnight in caves in Surat Thani,Nakhon Si Thammarat,Satun and Songkhla provinces from February to December 2017.Measurement of 23 external and internal morphological characteristics was conducted.Data were tested with preliminary statistics(Kolmogorov-Smirnov test,Levene’s test and Box’s test of equality of covariance matrices)and by one-way ANOVA or Kruskal-Wallis test.Measurements were analyzed using canonical discriminant analysis.Results:There were 11 morphological characteristics with high variability while two characteristics exhibited low variation.The sand fly populations from Nakhon Si Thammarat,Satun and Songkhla provinces were very similar but were separate from that in Surat Thani province based on canonical discriminant analysis data.This indicates that the morphological variation founding is a result of the diversity of habitats in each population and the geographic features of caves in each area,such as their altitude above sea level.Conclusions:There is a certain variation in the morphology of Sergentomyia anodontis sand flies at the population level which may be used for future classification of sand flies.展开更多
OBJECTIVE: To assess Atractylodis Rhizoma Alba extract(ARE) neuroprotective function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice and related genes. METHODS: Examined m RNA-DNA methylation change...OBJECTIVE: To assess Atractylodis Rhizoma Alba extract(ARE) neuroprotective function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice and related genes. METHODS: Examined m RNA-DNA methylation changes induced by ARE in MPTP-induced Parkinson's disease(PD) model's substantia nigra. RESULTS: ARE mitigated MPTP-induced motor impairment in rotarod and open field tests and preserved tyrosine hydroxylase-positive neuronal cells in substantia nigra and striatum. Genome RNA-Sequencing and Methyl-Sequencing in substantia nigra of vehicle/ARE-treated MPTP-induced PD mice showed 84 differentially expressed genes(DEGs) and 1804 differentially methylated regions(DMRs). Upregulated genes involved zinc ion homeostasis, cilium protein localization, and transcription;downregulated genes linked to ephrin receptor signaling, somitogenesis, and gene expression regulation. Hyper/hypomethylated DMRs post-ARE treatment associated with Wnt signaling, mitochondrial organization, dopamine biosynthesis, and hindbrain development. No significant correlation between DEGs and methylated genes related to PD pathogenesis. CONCLUSION: This research has identified the epigenetic targets of ARE's therapeutic action and gives insight on how ARE protects neurons in Parkinson's disease.展开更多
Objective:To study the number of leptospirosis cases in relations to the seasonal pattern,and its association with climate factors.Methods:Time series analysis was used to study the time variations in the number of le...Objective:To study the number of leptospirosis cases in relations to the seasonal pattern,and its association with climate factors.Methods:Time series analysis was used to study the time variations in the number of leptospirosis cases.The Autoregressive Integrated Moving Average (ARIMA) model was used in data curve fitting and predicting the next leptospirosis cases. Results:We found that the amount of rainfall was correlated to leptospirosis cases in both regions of interest,namely the northern and northeastern region of Thailand,while the temperature played a role in the northeastern region only.The use of multivariate ARIMA(ARIMAX) model showed that factoring in rainfall(with an 8 months lag) yields the best model for the northern region while the model,which factors in rainfall(with a 10 months kg) and temperature(with an 8 months lag) was the best for the northeaslern region.Conclusions:The models are able to show the trend in leptospirosis cases and closely fit the recorded data in both regions.The models can also be used to predict the next seasonal peak quite accurately.展开更多
Background:Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side effects.The aim of the present work was ...Background:Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side effects.The aim of the present work was to compare the changes in the main components of hemostasis under experimental drug-induced hepatosis and hepatitis in rats.Methods:We modeled diclofenac-induced hepatitis and tetracycline-induced hepa-tosis.Hemostasis response was gauged by measuring fibrinogen,factor X,protein C(PC),and prothrombin in plasma.The decarboxylated form of prothrombin was de-tected by measuring prothrombin index and ecamulin index.Platelet reactivity was studied using aggregometry.Results:Both hepatitis and hepatosis decreased the synthesis of fibrinogen,factor X,and prothrombin.However,protein carboxylation was not disrupted in hepatosis but was much impaired in hepatitis.PC decreased in both models as a consequence of its consumption possibly during inflammatory response.Platelet aggregation rate was lower in hepatosis but higher in hepatitis.Conclusions:Our findings imply the need for a thorough monitoring of the hemostasis system in liver diseases to avoid possible thrombotic complications.Its state indicates the disorder's rate and character.展开更多
On the model of Cu-induced liver fibrosis, the relationship between the activity of prooxidant-antioxidant system, immune system parameters, liver morphology and several physiological parameters (body temperature and ...On the model of Cu-induced liver fibrosis, the relationship between the activity of prooxidant-antioxidant system, immune system parameters, liver morphology and several physiological parameters (body temperature and performance ability of the animals, taking into account their ages) was investigated. Classical biochemical, immunological, histological and physiological methods of investigation were used. The subjects of the study were male Wistar rats of 3-month (young) and 20-month (old) age. For the induction of liver fibrosis, experimental animals were successively injected with copper sulfate (three times at intervals of 24 hours at a dose corresponding to 33% of the lethal one). It was shown that after five days of sulfate copper administration inflammatory reactions in the liver, damage of the vessel epithelium, an increase in collagen content, and other morphological changes were detected. At this time, the content of lipid hydroperoxides in the liver and blood serum was increased, the activity of a number of antioxidant enzymes was reduced, and the activity of aconitase was two times less compared to values in the control group. These changes correlated with a decrease in the amount and activity of phagocytic cells in the blood of experimental animals. Inhibition of the general metabolism was accompanied by a decrease in body temperature, loss of body weight and performance ability. The relationship between a specific metabolic pattern in animals with Cu-induced fibrosis was age-dependent. The formed specific adaptive metabolic pattern is unstable, and in the future it can be realized in one of three possible adaptive strategies, the choice of which is influenced by age.展开更多
The works of Alvaro Siza have been referred that they were not the theoretical architecture but the sensual and experiential one. His works were designed on the base of their locality that each of them located. For th...The works of Alvaro Siza have been referred that they were not the theoretical architecture but the sensual and experiential one. His works were designed on the base of their locality that each of them located. For the study, I selected a work of him, which was the Mimesis Art Museum at Paju in South Korea, and reviewed existing literatures to understand how he controlled the light and created the architectural spaces and forms in relation with the light, and I measured the illumination levels of the inside areas of the Mimesis Art Museum, and then, I surveyed the visitors’ responses on the lighting conditions of the Mimesis Art Museum. The results of the measurements showed that the illumination levels of the Mimesis Art museum on the first floor were effectively controlled to display the art works. The illumination levels on the third floor, however, were much higher than recommended illumination values for museum because of less controlled natural light. Therefore, more considerations to control the natural light are needed to secure stable environment in the exhibition spaces. Meanwhile, the answers of questionnaires concerning the quality of lighting conditions in the Mimesis Art Museum showed that the natural light was so effective to light the museum although the natural light illuminated some areas of the museum with high illumination levels.展开更多
BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms...BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones.展开更多
Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathologic...Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathological examination of metastatic sites which included an ulcer in the gastric body and a mass in the rectum. Metastatic disease also involved the liver as well. Patient was treated with systemic chemotherapy but unfortunately expired five months after the diagnosis was made.展开更多
In this paper, we present a proof-of-concept study of the enhancement of photocatalytic activity via a combined strategy of fabricating a visible-light responsive ternary heterostructure and improving overall photosta...In this paper, we present a proof-of-concept study of the enhancement of photocatalytic activity via a combined strategy of fabricating a visible-light responsive ternary heterostructure and improving overall photostability by incorporating magnetic zinc oxide/graphene/iron oxide (ZGF). A solvothermal approach was used to synthesize the catalyst. X-ray diffraction (XRD), scanning electron microscopic, energy dispersive X-ray, transmission electron microscopic, vibrating sample magnetometric, and ultraviolet–visible diffuse reflectance spectroscopic techniques were used to characterize the synthesized samples. The obtained optimal Zn(NO_(3))_(2) concentration, temperature, and heating duration were 0.10 mol/L, 600℃, and 1 h, respectively. The XRD pattern revealed the presence of peaks corresponding to zinc oxide, graphene, and iron oxide, indicating that the ZGF catalyst was effectively synthesized. Furthermore, when the developed ZGF was used for methylene blue dye degradation, the optimum irradiation time, dye concentration, catalyst dosage, irradiation intensity, and solution pH were 90 min, 10 mg/L, 0.03 g/L, 100 W, and 8.0, respectively. Therefore, the synthesized ZGF system could be used as a catalyst to degrade dyes in wastewater samples. This hybrid nanocomposite consisting of zinc oxide, graphene, and iron oxide could also be used as an effective photocatalytic degrader for various dye pollutants.展开更多
Rutherford backscattering spectroscopy (RBS) with channeling technique has been used to analyze the damage and its annealing of Si+ and P+ implanted InP:Fe. 150 keV Si ions and 160 keV P ions were implanted with doses...Rutherford backscattering spectroscopy (RBS) with channeling technique has been used to analyze the damage and its annealing of Si+ and P+ implanted InP:Fe. 150 keV Si ions and 160 keV P ions were implanted with doses ranging from 1×1013 to 1×1015 / cm2 at room temperature, 200℃ and 77K. Thermal annealing was performed in a conventional open tube furnace under flow of pure N2 for 15 minutes. Annealing temperature was chosen from 150℃ to 800 ℃ It was found that a dose of 8×1013cm2 Si+ was sufficient to produce an amorphous layer at room temperature and its epitaxial regrowth takes place at temperature below 150 ℃. The epitaxial regrowth of amorphous layer produced by 1×1014/cm2 Si ions occurs from both substrate and surface while that produced by co-implantation of 1×1014 /cm2 Si ions with the same dose of P ions takes place from substrate only. It was also noticed that for the former sample, its amorphized layer can be nearly completely recrystallized by epitaxial growth at 650 ℃, but for the latter much residual disorder remains even after annealing at 750 ℃. As for 77K implant at dose as low as 5×1013/cm2, Si ions begin to produce an amorphous layer that can be wholly reordered at 750℃. Samples implanted at 200℃remain crystalline only with small fraction of disorder due to self-annealing effect during the implantation. The damage annealing in the implanted layer corresponds to the change of electrical parameters got from Hall measurements.展开更多
The objective of this study was to analyze the indications of cesarean sections performed in a Level II clinic and to evaluate early maternal and neonatal outcome in the context of decentralization of obstetric and em...The objective of this study was to analyze the indications of cesarean sections performed in a Level II clinic and to evaluate early maternal and neonatal outcome in the context of decentralization of obstetric and emergency newborn care. Material and Method: This was a retrospective descriptive and analytical study conducted at the maternity CSNC over a period of 12 months from 1 July 2010 to 30 June 2011. It included all women in childbirth by caesarean section and excluded patients admitted for management of complications of cesarean section performed in another structure. Results: During the study period, 595 caesarean sections were performed on a total of 4410 births, a rate of 13.5%. The average age of patients was 27 years. The mean parity was 2. The patients came from them even 55%. They were admitted with a single uterine scar in 28.40% of cases and bi-scar in 25.4% of cases. A pathology was associated with pregnancy in 31.6% of cases. These pathologies were dominated by vascular and renal syndromes (75.5%), anemia (13.8%) and the obstacles previa (10.1%). Caesarean sections were performed in 517 patients in emergency. The technique of Misgav Ladach was the most common 75.1%. The average hospital stay was 4.2 days with extremes of 0 and 15 days. Postoperative maternal mortality was 0.34%. Operative follow-up was simple in 98.3% of patients. Two patients (0.34%) died after surgery. In 92.4% of the cases, the newborns were alive. The Apgar score in the first minute was favorable (greater than or equal to 7/10) in 503 newborns (95.1%) and unfavorable (less than 7/10) in 47 cases (8.55%). At the fifth minute, he was favorable in 98.5% of the cases. Overall stillbirth was 72.26‰ with a total of 43 stillbirths including 3 macerated stillbirths. Conclusion: Cesarean section is by far the most accomplished action in gynecology and obstetrics. Its ease of implementation and low cost, and of course his results in terms of reduction of maternal-fetal morbidity and mortality make a key intervention and allowed its extension.展开更多
[Objectives]The paper was to investigate the correlation between the microscopic characteristic constants and the index component polysaccharide content of Dendrobium officinale from Guangxi.[Methods]The paraffin sect...[Objectives]The paper was to investigate the correlation between the microscopic characteristic constants and the index component polysaccharide content of Dendrobium officinale from Guangxi.[Methods]The paraffin sections of D.officinale were made,and the microscopic characteristic constants of D.officinale stem,including cross section area,vascular bundle area and phloem area,were determined by NIS-Elements D microscopic image processing software.The contents of polysaccharides in D.officinale were determined by UV-Vis spectrophotometry,and the quantitative values of microscopic characteristics of D.officinale with different growth years were analyzed by SPSS 23.0(IBM SPSS Statistics 23.0)data statistical software.The correlation between quantitative microscopic characteristics of D.officinale and its polysaccharide content was analyzed.[Results]According to the correlation between the index component of D.officinale and its quantitative microscopic characteristics,the measurement indexes,the percentage of vascular bundle in the cross section area and the percentage of hard structure in the cross section area,were strongly negatively correlated with polysaccharide content.[Conclusions]The microscopic characteristic constant values of vascular bundles of D.officinale can be used as a method to verify polysaccharide content.展开更多
In this paper,key dimensions of a co-axial dual-mechanical-port flux-switching permanent magnet(CADMP-FSPM)machine for fuel-based extended range electric vehicles(ER-EVs),including split ratio,stator/rotor pole arcs,r...In this paper,key dimensions of a co-axial dual-mechanical-port flux-switching permanent magnet(CADMP-FSPM)machine for fuel-based extended range electric vehicles(ER-EVs),including split ratio,stator/rotor pole arcs,rotor yoke thickness,etc.,are analyzed and optimized.Firstly,the topologies and operation principles of an exampled 3-phase CADMP-FSPM are introduced briefly,in which an inner-rotor FSPM machine with 12-stator-slots/10-rotor-poles for high-speed generation and an outer-rotor FSPM machine with 12-stator-slots/22-rotor-poles for low-speed motoring are assembled co-axially.Then,the relationship between the key dimensions and electromagnetic performance,particularly for electromagnetic torque(power),of the CADMP-FSPM machine is studied by 2D-finite element analysis(FEA).Further,the reasonable matches of split ratio,rotor/stator pole arcs and rotor yoke are determined and the original CADMP-FSPM machine is optimized correspondingly.Finally,the static characteristics,including no-load PM flux-linkage,electro-motive-force(EMF),winding inductances,cogging torques and electromagnetic torques,of the original and optimized machines are compared by 2D-FEA.The results verify that the optimized CADMP-FSPM machine can exhibit improved torque characteristics than the original one,i.e.,the torque ripples of the inner and outer machines can be reduced by 22.7%and 4.7%,respectively,and the average torque of the inner and outer machines can be increased by 0.43Nm and 2Nm,respectively.展开更多
Despite the efforts made to fight the tuberculosis, <i><i><span style="font-family:Verdana;">Mycobacterium tuberculosis</span></i><span style="font-family:Verdana;"...Despite the efforts made to fight the tuberculosis, <i><i><span style="font-family:Verdana;">Mycobacterium tuberculosis</span></i><span style="font-family:Verdana;"></span></i> still remains a public health problem, particularly for low-income countries. According to the World Health Organization data, our country, Mali has detected only half of the 10,385 cases of tuberculosis expected for 2014 for a population of 17,309,000 inhabitants. The objective of this present work was to describe the different clinical aspects and the epidemiology of tuberculosis at Hospital Sominé Dolo <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">in</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Mopti. We performed a retro-prospective and descriptive of tuberculosis cases diagnosed in our department of medicine between May 2016 and August 2018. A total of 96 tuberculosis cases were recorded, <i></i></span><i><i><span style="font-family:Verdana;">i.e</span></i><span style="font-family:Verdana;">.</span></i> 4.6% and 1.0% for hospitalizations and consultations patterns, respectively. The median of age was 41 with extremes from 5 to 80 years. The age group [31</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">40 years] was the most affected with 20.8%. Men and women were affected in identical proportions, <i></i></span><i><i><span style="font-family:Verdana;">i.e</span></i><span style="font-family:Verdana;">.</span></i> 50%. Pulmonary locations were the most frequent with 55.2%. Pleural tuberculosis was far the most frequent of the extra-pulmonary forms with 24.0% followed by the peritoneal and bone localization with 6.3% each. The majority of patients were followed on an outpatient basis, <i></i></span><i><i><span style="font-family:Verdana;">i.e</span></i><span style="font-family:Verdana;">.</span></i> 90.6%. The disease lethality was 7.3%. Our data show that the cases of extra</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">pulmonary tuberculosis are in an increasing proportion and their diagnosis confirmation remains difficult in our context.</span></span></span>展开更多
Rapid developments in hardware, software, and communication technologies have facilitated the emergence of Internet-connected sensory devices that provide observations and data measurements from the physical world. By...Rapid developments in hardware, software, and communication technologies have facilitated the emergence of Internet-connected sensory devices that provide observations and data measurements from the physical world. By 2020, it is estimated that the total number of Internet-connected devices being used will be between 25 and 50 billion. As these numbers grow and technologies become more mature, the volume of data being published will increase. The technology of Internet-connected devices, referred to as Internet of Things （IoT）, continues to extend the current Internet by providing connectivity and interactions between the physical and cyber worlds. In addition to an increased volume, the IoT generates big data characterized by its velocity in terms of time and location dependency, with a variety of multiple modalities and varying data quality. Intelligent processing and analysis of this big data are the key to developing smart IoT applications. This article assesses the various machine learning methods that deal with the challenges presented by IoT data by considering smart cities as the main use case. The key contribution of this study is the presentation of a taxonomy of machine learning algorithms explaining how different techniques are applied to the data in order to extract higher level information. The potential and challenges of machine learning for IoT data analytics will also be discussed. A use case of applying a Support Vector Machine （SVM） to Aarhus smart city traffic data is presented for a more detailed exploration.展开更多
In order to improve the harsh dynamic environment experienced by heavy rockets during different external excitations,this study presents a novel active variable stiffness vibration isolator(AVS-VI)used as the vibratio...In order to improve the harsh dynamic environment experienced by heavy rockets during different external excitations,this study presents a novel active variable stiffness vibration isolator(AVS-VI)used as the vibration isolation device to reduce excessive vibration of the whole-spacecraft isolation system.The AVS-VI is composed of horizontal stiffness spring,positive stiffness spring,parallelogram linkage mechanism,piezoelectric actuator,acceleration sensor,viscoelastic damping,and PID active controller.Based on the AVS-VI,the generalized vibration transmissibility determined by the nonlinear output frequency response functions and the energy absorption rate is applied to analyze the isolation performance of the whole-spacecraft system with AVS-VI.The AVS-VI can conduct adaptive vibration suppression with variable stiffness to the whole-spacecraft system,and the analysis results indicate that the AVS-VI is efTective in reducing the extravagant vibration of the whole-spacecraft system,where the vibration isolation is decreased up to above 65%under different acceleration excitations.Finally,different parameters of AVS-VI are considered to optimize the whole-spacecraft system based on the generalized vibration transmissibility and the energy absorption rate.展开更多
Background Inflammation of the mammary tissue(mastitis)is one of the most detrimental health conditions in dairy ruminants and is considered the most economically important infectious disease of the dairy sector.Impro...Background Inflammation of the mammary tissue(mastitis)is one of the most detrimental health conditions in dairy ruminants and is considered the most economically important infectious disease of the dairy sector.Improving mastitis resistance is becoming an important goal in dairy ruminant breeding programmes.However,mastitis resistance is a complex trait and identification of mastitis-associated alleles in livestock is difficult.Currently,the only applicable approach to identify candidate loci for complex traits in large farm animals is to combine different information that supports the functionality of the identified genomic regions with respect to a complex trait.Methods To identify the most promising candidate loci for mastitis resistance we integrated heterogeneous data from multiple sources and compiled the information into a comprehensive database of mastitis-associated candidate loci.Mastitis-associated candidate genes reported in association,expression,and mouse model studies were collected by searching the relevant literature and databases.The collected data were integrated into a single database,screened for overlaps,and used for gene set enrichment analysis.Results The database contains candidate genes from association and expression studies and relevant transgenic mouse models.The 2448 collected candidate loci are evenly distributed across bovine chromosomes.Data integration and analysis revealed overlaps between different studies and/or with mastitis-associated QTL,revealing promising candidate genes for mastitis resistance.Conclusion Mastitis resistance is a complex trait influenced by numerous alleles.Based on the number of independent studies,we were able to prioritise candidate genes and propose a list of the 22 most promising.To our knowledge this is the most comprehensive database of mastitis associated candidate genes and could be helpful in selecting genes for functional validation studies.展开更多
Recently, damage caused by liquid droplet impingement erosion (LDIE) in addition to flow-accelerated corrosion (FAC) has frequently occurred in the secondary side steam piping of nuclear power plants, and the damage-o...Recently, damage caused by liquid droplet impingement erosion (LDIE) in addition to flow-accelerated corrosion (FAC) has frequently occurred in the secondary side steam piping of nuclear power plants, and the damage-occurring frequency is expected to increase as their operating years’ increase. In order to scrutinize its causes, therefore, an experimental study was conducted to understand how the behavior of LDIE-FAC multiple degradation changes when the piping of nuclear power plants is operated for a long time. Experimental results show that more magnetite was formed on the surface of the carbon steel specimen than on the low-alloy steel specimen, and that the rate of magnetite formation and extinction reached equilibrium due to the complex action of liquid droplet impingement erosion and flow-accelerated corrosion after a certain period of time. Furthermore, it was confirmed at the beginning of the experiment that A106 Gr.B specimen has more mass loss than A335 P22 specimen. After a certain period of time, however, the mass loss tends to be the opposite. This is presumed to have resulted from the magnetite formed on the surface playing a role in suppressing liquid droplet impingement erosion. In addition, it was confirmed that the amount of erosion linearly increases under the conditions in which the formation and extinction of magnetite reach equilibrium.展开更多
Most biochemical processes in cells are usually modeled by reaction-diffusion （RD） equations. In these RD models, the diffusive process is assumed to be Gaussian. However, a growing number of studies have noted that...Most biochemical processes in cells are usually modeled by reaction-diffusion （RD） equations. In these RD models, the diffusive process is assumed to be Gaussian. However, a growing number of studies have noted that intracellular diffusion is anomalous at some or all times, which may result from a crowded environment and chemical kinetics. This work aims to computationally study the effects of chemical reactions on the diffusive dynamics of RD systems by using both stochastic and deterministic algorithms. Numerical method to estimate the mean-square displacement （MSD） from a deterministic algorithm is also investigated. Our computational results show that anomalous diffusion can be solely due to chemical reactions. The chemical reactions alone can cause anomalous sub-diffusion in the RD system at some or all times. The time-dependent anomalous diffusion exponent is found to depend on many parameters, including chemical reaction rates, reaction orders, and chemical concentrations.展开更多
文摘An improved meshfree moving-Kriging(MK)formulation for free vibration analysis of functionally graded material-functionally graded carbon nanotube-reinforced composite(FGM-FGCNTRC)sandwich shells is first proposed in this article.The proposed sandwich structure consists of skins of FGM layers and an FGCNTRC core.This structure possesses all the advantages of FGM and FGCNTRC,including high electrical or thermal insulating properties,high fatigue resistance,good corrosion resistance,high stiffness,low density,high strength,and high aspect ratios.Such sandwich structures can be used to replace conventional FGM structures.The present formulation has been established by using an improved meshfree MK method and the first-order shear deformation shell theory(FSDT).The effective material characteristics of the FGM-skin layers and the FGCNTRC core were calculated using the rule of mixture.Key parameters and factors such as the thickness-to-radius ratio,the length-to-radius ratio,layer-thickness ratios,CNT distributions,the volume fraction of CNTs,the power-law index,and various boundary conditions were rigorously investigated.A nonlinear CNT distribution that we term FG-nX is first proposed in this work,and many new results of FGM-FGCNTRC sandwich shells have been provided.
基金supported by the Faculty of Science Research Fund,Prince of Songkla University,Contract No.1-2559-02-012supported by the Prince of Songkla University,Contract No.MET610469S
文摘Objective:To determine the morphological characteristics of variations in populations of female adult sand fly,Sergentomyia anodontis Quate and Fairchild,1961 in caves in southern Thailand using morphometric analysis.Methods:A total of 107 female Sergentomyia anodontis were isolated from 651 sand flies captured by CDC light traps overnight in caves in Surat Thani,Nakhon Si Thammarat,Satun and Songkhla provinces from February to December 2017.Measurement of 23 external and internal morphological characteristics was conducted.Data were tested with preliminary statistics(Kolmogorov-Smirnov test,Levene’s test and Box’s test of equality of covariance matrices)and by one-way ANOVA or Kruskal-Wallis test.Measurements were analyzed using canonical discriminant analysis.Results:There were 11 morphological characteristics with high variability while two characteristics exhibited low variation.The sand fly populations from Nakhon Si Thammarat,Satun and Songkhla provinces were very similar but were separate from that in Surat Thani province based on canonical discriminant analysis data.This indicates that the morphological variation founding is a result of the diversity of habitats in each population and the geographic features of caves in each area,such as their altitude above sea level.Conclusions:There is a certain variation in the morphology of Sergentomyia anodontis sand flies at the population level which may be used for future classification of sand flies.
基金the Development of Sustainable Application for Standard Herbal Resource by the Korea Institute of Oriental Medicine (No. KSN2012320)。
文摘OBJECTIVE: To assess Atractylodis Rhizoma Alba extract(ARE) neuroprotective function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated mice and related genes. METHODS: Examined m RNA-DNA methylation changes induced by ARE in MPTP-induced Parkinson's disease(PD) model's substantia nigra. RESULTS: ARE mitigated MPTP-induced motor impairment in rotarod and open field tests and preserved tyrosine hydroxylase-positive neuronal cells in substantia nigra and striatum. Genome RNA-Sequencing and Methyl-Sequencing in substantia nigra of vehicle/ARE-treated MPTP-induced PD mice showed 84 differentially expressed genes(DEGs) and 1804 differentially methylated regions(DMRs). Upregulated genes involved zinc ion homeostasis, cilium protein localization, and transcription;downregulated genes linked to ephrin receptor signaling, somitogenesis, and gene expression regulation. Hyper/hypomethylated DMRs post-ARE treatment associated with Wnt signaling, mitochondrial organization, dopamine biosynthesis, and hindbrain development. No significant correlation between DEGs and methylated genes related to PD pathogenesis. CONCLUSION: This research has identified the epigenetic targets of ARE's therapeutic action and gives insight on how ARE protects neurons in Parkinson's disease.
基金supported by Centre of Encellecne Mathentatics CHEThailand finanieally Sudaral Chadsuthi is supported by the Commission on Higher Education Thailand for its grant support under the Strategie Scholarships for Frintier Research Network for joint Ph.D.Programssupported by the National Science and Technology Development Agency (NSTDA) and Faculty of Science,Mahidol University
文摘Objective:To study the number of leptospirosis cases in relations to the seasonal pattern,and its association with climate factors.Methods:Time series analysis was used to study the time variations in the number of leptospirosis cases.The Autoregressive Integrated Moving Average (ARIMA) model was used in data curve fitting and predicting the next leptospirosis cases. Results:We found that the amount of rainfall was correlated to leptospirosis cases in both regions of interest,namely the northern and northeastern region of Thailand,while the temperature played a role in the northeastern region only.The use of multivariate ARIMA(ARIMAX) model showed that factoring in rainfall(with an 8 months lag) yields the best model for the northern region while the model,which factors in rainfall(with a 10 months kg) and temperature(with an 8 months lag) was the best for the northeaslern region.Conclusions:The models are able to show the trend in leptospirosis cases and closely fit the recorded data in both regions.The models can also be used to predict the next seasonal peak quite accurately.
基金National Academy of Sciences of Ukraine research,Grant/Award Number:0119U002512。
文摘Background:Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side effects.The aim of the present work was to compare the changes in the main components of hemostasis under experimental drug-induced hepatosis and hepatitis in rats.Methods:We modeled diclofenac-induced hepatitis and tetracycline-induced hepa-tosis.Hemostasis response was gauged by measuring fibrinogen,factor X,protein C(PC),and prothrombin in plasma.The decarboxylated form of prothrombin was de-tected by measuring prothrombin index and ecamulin index.Platelet reactivity was studied using aggregometry.Results:Both hepatitis and hepatosis decreased the synthesis of fibrinogen,factor X,and prothrombin.However,protein carboxylation was not disrupted in hepatosis but was much impaired in hepatitis.PC decreased in both models as a consequence of its consumption possibly during inflammatory response.Platelet aggregation rate was lower in hepatosis but higher in hepatitis.Conclusions:Our findings imply the need for a thorough monitoring of the hemostasis system in liver diseases to avoid possible thrombotic complications.Its state indicates the disorder's rate and character.
文摘On the model of Cu-induced liver fibrosis, the relationship between the activity of prooxidant-antioxidant system, immune system parameters, liver morphology and several physiological parameters (body temperature and performance ability of the animals, taking into account their ages) was investigated. Classical biochemical, immunological, histological and physiological methods of investigation were used. The subjects of the study were male Wistar rats of 3-month (young) and 20-month (old) age. For the induction of liver fibrosis, experimental animals were successively injected with copper sulfate (three times at intervals of 24 hours at a dose corresponding to 33% of the lethal one). It was shown that after five days of sulfate copper administration inflammatory reactions in the liver, damage of the vessel epithelium, an increase in collagen content, and other morphological changes were detected. At this time, the content of lipid hydroperoxides in the liver and blood serum was increased, the activity of a number of antioxidant enzymes was reduced, and the activity of aconitase was two times less compared to values in the control group. These changes correlated with a decrease in the amount and activity of phagocytic cells in the blood of experimental animals. Inhibition of the general metabolism was accompanied by a decrease in body temperature, loss of body weight and performance ability. The relationship between a specific metabolic pattern in animals with Cu-induced fibrosis was age-dependent. The formed specific adaptive metabolic pattern is unstable, and in the future it can be realized in one of three possible adaptive strategies, the choice of which is influenced by age.
文摘The works of Alvaro Siza have been referred that they were not the theoretical architecture but the sensual and experiential one. His works were designed on the base of their locality that each of them located. For the study, I selected a work of him, which was the Mimesis Art Museum at Paju in South Korea, and reviewed existing literatures to understand how he controlled the light and created the architectural spaces and forms in relation with the light, and I measured the illumination levels of the inside areas of the Mimesis Art Museum, and then, I surveyed the visitors’ responses on the lighting conditions of the Mimesis Art Museum. The results of the measurements showed that the illumination levels of the Mimesis Art museum on the first floor were effectively controlled to display the art works. The illumination levels on the third floor, however, were much higher than recommended illumination values for museum because of less controlled natural light. Therefore, more considerations to control the natural light are needed to secure stable environment in the exhibition spaces. Meanwhile, the answers of questionnaires concerning the quality of lighting conditions in the Mimesis Art Museum showed that the natural light was so effective to light the museum although the natural light illuminated some areas of the museum with high illumination levels.
基金Supported by Key R&D Program of Jiangsu Province,No.BE2019712British Heart Foundation,No.PG/14/19/30751 and No.PG/16/65/32313.
文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones.
文摘Adenocarcinoma of the lung infrequently metastasizes to the gastrointestinal tract. We report a rare case of a 65-year-old male with no respiratory symptoms diagnosed with adenocarcinoma of the lung by histopathological examination of metastatic sites which included an ulcer in the gastric body and a mass in the rectum. Metastatic disease also involved the liver as well. Patient was treated with systemic chemotherapy but unfortunately expired five months after the diagnosis was made.
基金supported by the Research and Development Institute at Nakhon Si Thammarat Rajabhat University and the Nanomaterials Chemistry Research Unit at Nakhon Si Thammarat Rajabhat University,Nakhon Si Thammarat,Thailand(Grant No.004/2563).
文摘In this paper, we present a proof-of-concept study of the enhancement of photocatalytic activity via a combined strategy of fabricating a visible-light responsive ternary heterostructure and improving overall photostability by incorporating magnetic zinc oxide/graphene/iron oxide (ZGF). A solvothermal approach was used to synthesize the catalyst. X-ray diffraction (XRD), scanning electron microscopic, energy dispersive X-ray, transmission electron microscopic, vibrating sample magnetometric, and ultraviolet–visible diffuse reflectance spectroscopic techniques were used to characterize the synthesized samples. The obtained optimal Zn(NO_(3))_(2) concentration, temperature, and heating duration were 0.10 mol/L, 600℃, and 1 h, respectively. The XRD pattern revealed the presence of peaks corresponding to zinc oxide, graphene, and iron oxide, indicating that the ZGF catalyst was effectively synthesized. Furthermore, when the developed ZGF was used for methylene blue dye degradation, the optimum irradiation time, dye concentration, catalyst dosage, irradiation intensity, and solution pH were 90 min, 10 mg/L, 0.03 g/L, 100 W, and 8.0, respectively. Therefore, the synthesized ZGF system could be used as a catalyst to degrade dyes in wastewater samples. This hybrid nanocomposite consisting of zinc oxide, graphene, and iron oxide could also be used as an effective photocatalytic degrader for various dye pollutants.
文摘Rutherford backscattering spectroscopy (RBS) with channeling technique has been used to analyze the damage and its annealing of Si+ and P+ implanted InP:Fe. 150 keV Si ions and 160 keV P ions were implanted with doses ranging from 1×1013 to 1×1015 / cm2 at room temperature, 200℃ and 77K. Thermal annealing was performed in a conventional open tube furnace under flow of pure N2 for 15 minutes. Annealing temperature was chosen from 150℃ to 800 ℃ It was found that a dose of 8×1013cm2 Si+ was sufficient to produce an amorphous layer at room temperature and its epitaxial regrowth takes place at temperature below 150 ℃. The epitaxial regrowth of amorphous layer produced by 1×1014/cm2 Si ions occurs from both substrate and surface while that produced by co-implantation of 1×1014 /cm2 Si ions with the same dose of P ions takes place from substrate only. It was also noticed that for the former sample, its amorphized layer can be nearly completely recrystallized by epitaxial growth at 650 ℃, but for the latter much residual disorder remains even after annealing at 750 ℃. As for 77K implant at dose as low as 5×1013/cm2, Si ions begin to produce an amorphous layer that can be wholly reordered at 750℃. Samples implanted at 200℃remain crystalline only with small fraction of disorder due to self-annealing effect during the implantation. The damage annealing in the implanted layer corresponds to the change of electrical parameters got from Hall measurements.
文摘The objective of this study was to analyze the indications of cesarean sections performed in a Level II clinic and to evaluate early maternal and neonatal outcome in the context of decentralization of obstetric and emergency newborn care. Material and Method: This was a retrospective descriptive and analytical study conducted at the maternity CSNC over a period of 12 months from 1 July 2010 to 30 June 2011. It included all women in childbirth by caesarean section and excluded patients admitted for management of complications of cesarean section performed in another structure. Results: During the study period, 595 caesarean sections were performed on a total of 4410 births, a rate of 13.5%. The average age of patients was 27 years. The mean parity was 2. The patients came from them even 55%. They were admitted with a single uterine scar in 28.40% of cases and bi-scar in 25.4% of cases. A pathology was associated with pregnancy in 31.6% of cases. These pathologies were dominated by vascular and renal syndromes (75.5%), anemia (13.8%) and the obstacles previa (10.1%). Caesarean sections were performed in 517 patients in emergency. The technique of Misgav Ladach was the most common 75.1%. The average hospital stay was 4.2 days with extremes of 0 and 15 days. Postoperative maternal mortality was 0.34%. Operative follow-up was simple in 98.3% of patients. Two patients (0.34%) died after surgery. In 92.4% of the cases, the newborns were alive. The Apgar score in the first minute was favorable (greater than or equal to 7/10) in 503 newborns (95.1%) and unfavorable (less than 7/10) in 47 cases (8.55%). At the fifth minute, he was favorable in 98.5% of the cases. Overall stillbirth was 72.26‰ with a total of 43 stillbirths including 3 macerated stillbirths. Conclusion: Cesarean section is by far the most accomplished action in gynecology and obstetrics. Its ease of implementation and low cost, and of course his results in terms of reduction of maternal-fetal morbidity and mortality make a key intervention and allowed its extension.
基金Supported by 2020 Operation Subsidy Project of Guangxi Key Research Laboratory of Zhuang&Yao Medicine(20-065-14)"Quantification of Microscopic Characteristics of Dendrobium officinale from Guangxi and Its Correlation with the Quality of Medicinal Materials"(GXZYYKF2020A-13)2011 Guangxi Collaborative Innovation Center"Pharmaceutical Collaborative Innovation Center of Zhuang&Yao Medicine"(GJKY[2013]20)+6 种基金Guangxi Engineering Research Center for Resources and Application of Ethnic Medicine(GFGGJH[2020]2605)National Natural Science Foundation of China(82060695)Joint Research Laboratory of Zhuang&Yao Medicine of Guangxi University of Traditional Chinese Medicine and Central South University(GKJZ[2021]238)Guangxi Science and Technology Base and Talent Project(GK AD19245090)2018 Research Start-up Fund Project of Guangxi University of Chinese Medicine for Introduced Doctors(2018BS019)2019 Basic Scientific Research Ability Improvement Project for Young and Middle-aged Teachers in Colleges and Universities in Guangxi(2019KY0310)2019-2021 Guangxi First-class Discipline Construction Open Project of Guangxi University of Traditional Chinese Medicine(2019XK101)。
文摘[Objectives]The paper was to investigate the correlation between the microscopic characteristic constants and the index component polysaccharide content of Dendrobium officinale from Guangxi.[Methods]The paraffin sections of D.officinale were made,and the microscopic characteristic constants of D.officinale stem,including cross section area,vascular bundle area and phloem area,were determined by NIS-Elements D microscopic image processing software.The contents of polysaccharides in D.officinale were determined by UV-Vis spectrophotometry,and the quantitative values of microscopic characteristics of D.officinale with different growth years were analyzed by SPSS 23.0(IBM SPSS Statistics 23.0)data statistical software.The correlation between quantitative microscopic characteristics of D.officinale and its polysaccharide content was analyzed.[Results]According to the correlation between the index component of D.officinale and its quantitative microscopic characteristics,the measurement indexes,the percentage of vascular bundle in the cross section area and the percentage of hard structure in the cross section area,were strongly negatively correlated with polysaccharide content.[Conclusions]The microscopic characteristic constant values of vascular bundles of D.officinale can be used as a method to verify polysaccharide content.
基金This work was supported by The National Basic Research Program(973 Program)(2013CB035603).
文摘In this paper,key dimensions of a co-axial dual-mechanical-port flux-switching permanent magnet(CADMP-FSPM)machine for fuel-based extended range electric vehicles(ER-EVs),including split ratio,stator/rotor pole arcs,rotor yoke thickness,etc.,are analyzed and optimized.Firstly,the topologies and operation principles of an exampled 3-phase CADMP-FSPM are introduced briefly,in which an inner-rotor FSPM machine with 12-stator-slots/10-rotor-poles for high-speed generation and an outer-rotor FSPM machine with 12-stator-slots/22-rotor-poles for low-speed motoring are assembled co-axially.Then,the relationship between the key dimensions and electromagnetic performance,particularly for electromagnetic torque(power),of the CADMP-FSPM machine is studied by 2D-finite element analysis(FEA).Further,the reasonable matches of split ratio,rotor/stator pole arcs and rotor yoke are determined and the original CADMP-FSPM machine is optimized correspondingly.Finally,the static characteristics,including no-load PM flux-linkage,electro-motive-force(EMF),winding inductances,cogging torques and electromagnetic torques,of the original and optimized machines are compared by 2D-FEA.The results verify that the optimized CADMP-FSPM machine can exhibit improved torque characteristics than the original one,i.e.,the torque ripples of the inner and outer machines can be reduced by 22.7%and 4.7%,respectively,and the average torque of the inner and outer machines can be increased by 0.43Nm and 2Nm,respectively.
文摘Despite the efforts made to fight the tuberculosis, <i><i><span style="font-family:Verdana;">Mycobacterium tuberculosis</span></i><span style="font-family:Verdana;"></span></i> still remains a public health problem, particularly for low-income countries. According to the World Health Organization data, our country, Mali has detected only half of the 10,385 cases of tuberculosis expected for 2014 for a population of 17,309,000 inhabitants. The objective of this present work was to describe the different clinical aspects and the epidemiology of tuberculosis at Hospital Sominé Dolo <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">in</span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Mopti. We performed a retro-prospective and descriptive of tuberculosis cases diagnosed in our department of medicine between May 2016 and August 2018. A total of 96 tuberculosis cases were recorded, <i></i></span><i><i><span style="font-family:Verdana;">i.e</span></i><span style="font-family:Verdana;">.</span></i> 4.6% and 1.0% for hospitalizations and consultations patterns, respectively. The median of age was 41 with extremes from 5 to 80 years. The age group [31</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">40 years] was the most affected with 20.8%. Men and women were affected in identical proportions, <i></i></span><i><i><span style="font-family:Verdana;">i.e</span></i><span style="font-family:Verdana;">.</span></i> 50%. Pulmonary locations were the most frequent with 55.2%. Pleural tuberculosis was far the most frequent of the extra-pulmonary forms with 24.0% followed by the peritoneal and bone localization with 6.3% each. The majority of patients were followed on an outpatient basis, <i></i></span><i><i><span style="font-family:Verdana;">i.e</span></i><span style="font-family:Verdana;">.</span></i> 90.6%. The disease lethality was 7.3%. Our data show that the cases of extra</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">pulmonary tuberculosis are in an increasing proportion and their diagnosis confirmation remains difficult in our context.</span></span></span>
文摘Rapid developments in hardware, software, and communication technologies have facilitated the emergence of Internet-connected sensory devices that provide observations and data measurements from the physical world. By 2020, it is estimated that the total number of Internet-connected devices being used will be between 25 and 50 billion. As these numbers grow and technologies become more mature, the volume of data being published will increase. The technology of Internet-connected devices, referred to as Internet of Things （IoT）, continues to extend the current Internet by providing connectivity and interactions between the physical and cyber worlds. In addition to an increased volume, the IoT generates big data characterized by its velocity in terms of time and location dependency, with a variety of multiple modalities and varying data quality. Intelligent processing and analysis of this big data are the key to developing smart IoT applications. This article assesses the various machine learning methods that deal with the challenges presented by IoT data by considering smart cities as the main use case. The key contribution of this study is the presentation of a taxonomy of machine learning algorithms explaining how different techniques are applied to the data in order to extract higher level information. The potential and challenges of machine learning for IoT data analytics will also be discussed. A use case of applying a Support Vector Machine （SVM） to Aarhus smart city traffic data is presented for a more detailed exploration.
基金the National Natural Science Foundation of China(Project Nos.12022213,11772205 and 11902203)the Scieatifie Research Fund of Liaoning Provineinl Education Department(No.L201703)+1 种基金the Program of Liaoning Revitalization Talents(XLYC1807172)the Tralning Project of Liaoning Higher Education Institutions in Domestic and Oveseas(Nos.2018LNGXGJWPY-YB008).
文摘In order to improve the harsh dynamic environment experienced by heavy rockets during different external excitations,this study presents a novel active variable stiffness vibration isolator(AVS-VI)used as the vibration isolation device to reduce excessive vibration of the whole-spacecraft isolation system.The AVS-VI is composed of horizontal stiffness spring,positive stiffness spring,parallelogram linkage mechanism,piezoelectric actuator,acceleration sensor,viscoelastic damping,and PID active controller.Based on the AVS-VI,the generalized vibration transmissibility determined by the nonlinear output frequency response functions and the energy absorption rate is applied to analyze the isolation performance of the whole-spacecraft system with AVS-VI.The AVS-VI can conduct adaptive vibration suppression with variable stiffness to the whole-spacecraft system,and the analysis results indicate that the AVS-VI is efTective in reducing the extravagant vibration of the whole-spacecraft system,where the vibration isolation is decreased up to above 65%under different acceleration excitations.Finally,different parameters of AVS-VI are considered to optimize the whole-spacecraft system based on the generalized vibration transmissibility and the energy absorption rate.
基金Slovenian Research Agency for funding through the progra mme grant no.P40220postgradua te"young researchers"funding to ZB。
文摘Background Inflammation of the mammary tissue(mastitis)is one of the most detrimental health conditions in dairy ruminants and is considered the most economically important infectious disease of the dairy sector.Improving mastitis resistance is becoming an important goal in dairy ruminant breeding programmes.However,mastitis resistance is a complex trait and identification of mastitis-associated alleles in livestock is difficult.Currently,the only applicable approach to identify candidate loci for complex traits in large farm animals is to combine different information that supports the functionality of the identified genomic regions with respect to a complex trait.Methods To identify the most promising candidate loci for mastitis resistance we integrated heterogeneous data from multiple sources and compiled the information into a comprehensive database of mastitis-associated candidate loci.Mastitis-associated candidate genes reported in association,expression,and mouse model studies were collected by searching the relevant literature and databases.The collected data were integrated into a single database,screened for overlaps,and used for gene set enrichment analysis.Results The database contains candidate genes from association and expression studies and relevant transgenic mouse models.The 2448 collected candidate loci are evenly distributed across bovine chromosomes.Data integration and analysis revealed overlaps between different studies and/or with mastitis-associated QTL,revealing promising candidate genes for mastitis resistance.Conclusion Mastitis resistance is a complex trait influenced by numerous alleles.Based on the number of independent studies,we were able to prioritise candidate genes and propose a list of the 22 most promising.To our knowledge this is the most comprehensive database of mastitis associated candidate genes and could be helpful in selecting genes for functional validation studies.
文摘Recently, damage caused by liquid droplet impingement erosion (LDIE) in addition to flow-accelerated corrosion (FAC) has frequently occurred in the secondary side steam piping of nuclear power plants, and the damage-occurring frequency is expected to increase as their operating years’ increase. In order to scrutinize its causes, therefore, an experimental study was conducted to understand how the behavior of LDIE-FAC multiple degradation changes when the piping of nuclear power plants is operated for a long time. Experimental results show that more magnetite was formed on the surface of the carbon steel specimen than on the low-alloy steel specimen, and that the rate of magnetite formation and extinction reached equilibrium due to the complex action of liquid droplet impingement erosion and flow-accelerated corrosion after a certain period of time. Furthermore, it was confirmed at the beginning of the experiment that A106 Gr.B specimen has more mass loss than A335 P22 specimen. After a certain period of time, however, the mass loss tends to be the opposite. This is presumed to have resulted from the magnetite formed on the surface playing a role in suppressing liquid droplet impingement erosion. In addition, it was confirmed that the amount of erosion linearly increases under the conditions in which the formation and extinction of magnetite reach equilibrium.
基金supported by the Thailand Research Fund and Mahidol University(Grant No.TRG5880157),the Thailand Center of Excellence in Physics(ThEP),CHE,Thailand,and the Development Promotion of Science and Technology
文摘Most biochemical processes in cells are usually modeled by reaction-diffusion （RD） equations. In these RD models, the diffusive process is assumed to be Gaussian. However, a growing number of studies have noted that intracellular diffusion is anomalous at some or all times, which may result from a crowded environment and chemical kinetics. This work aims to computationally study the effects of chemical reactions on the diffusive dynamics of RD systems by using both stochastic and deterministic algorithms. Numerical method to estimate the mean-square displacement （MSD） from a deterministic algorithm is also investigated. Our computational results show that anomalous diffusion can be solely due to chemical reactions. The chemical reactions alone can cause anomalous sub-diffusion in the RD system at some or all times. The time-dependent anomalous diffusion exponent is found to depend on many parameters, including chemical reaction rates, reaction orders, and chemical concentrations.
