Doping is essential for modulating semiconductor conductivity,forming p-n junctions,and reducing contact resistance[1].Notably,as organic semiconductors(OSCs)advance toward high performance,flexibility,and miniaturiza...Doping is essential for modulating semiconductor conductivity,forming p-n junctions,and reducing contact resistance[1].Notably,as organic semiconductors(OSCs)advance toward high performance,flexibility,and miniaturization,achieving precise regionally selective doping becomes critical for building complex,highly integrated devices[2].In inorganic semiconductors(e.g.,silicon),sub-100-nanometer regional doping is achievable through photolithography and ion implantation—techniques foundational to modern complementary metaloxide-semiconductor(CMOS)technology[3].展开更多
Microwave absorption(MA)materials often face poor synergy between impedance matching and attenuation in the low-frequency range.Balancing permittivity and permeability through magnetic-dielectric synergy is a promisin...Microwave absorption(MA)materials often face poor synergy between impedance matching and attenuation in the low-frequency range.Balancing permittivity and permeability through magnetic-dielectric synergy is a promising strategy to address this issue.To realize the synergy,herein,Sn whiskers with an in situ oxide layer served as substrates for magnetic-loss-active CoNi nanosheet growth,forming a hierarchical CoNi@SnO_(2)@Sn(CNS)heterostructure.The CNS absorber achieves a minimum reflection loss(RL_(min))value of-62.29 dB with an effective absorption bandwidth(EAB)of 2.2 GHz,covering the entire C-band with 70%absorption at only 2.61 mm thickness.The nanosheet design of CoNi enhances magnetic anisotropy to promote natural resonance,while the conductive Sn core and abundant Sn/SnO_(2) and CoNi/SnO_(2) heterointerfaces facilitate conduction loss and dielectric polarization.When composited into a thermoplastic polyurethane(TPU)matrix,the resulting CNS/TPU-2 film(20 wt%CNS)exhibits an RL_(min) value of-61.04 dB and a 2.5 GHz EAB.Its in-plane and through-plane thermal conductivities reach 2.41 and 0.51 W m^(-1) K^(-1),representing 4.1 and 2.6 times those of pure TPU films,respectively,facilitating heat dissipation from protected devices.This work provides valuable insights into magnetic-dielectric synergy for low-frequency MA of 1D metal-based materials,offering promising potential for 5G communications and flexible electronics.展开更多
Background:The present study evaluated the psychometric properties of Problematic Internet Use(PIU)instruments and their correlation with psychological distress and time spent on Internet activities among university s...Background:The present study evaluated the psychometric properties of Problematic Internet Use(PIU)instruments and their correlation with psychological distress and time spent on Internet activities among university students in Ghana.Methods:In the present cross-sectional survey design study,520 participants(35.96% female)were recruited with a mean age of 19.55 years(SD=1.94)from several university departments(i.e.,Behavioral Sciences,Materials Engineering,Nursing and Midwifery,and Biochemistry and Biotechnology)of Kwame Nkrumah University of Science and Technology(KNUST)between 19 July and 04 August,2023.Participants completed a survey that included the following measures:the Gaming Disorder Test(GDT),Gaming Disorder Scale for Adolescents(GADIS-A),Internet Gaming Disorder Scale-Short Form(IGDS9-SF),Bergen Social Media Addiction Scale(BSMAS),Smartphone Application Based Addiction Scale(SABAS),Nomophobia Questionnaire(NMP-Q),and the external criterion measure:Depression Anxiety Stress Scale-21(DASS-21).Confirmatory factor analysis(CFA)was carried out to evaluate the structure of the instruments.Cronbach’s α,McDonald’s ω,and composite reliability were used to evaluate internal consistency.Pearson correlation was used to examine the associations between the scores of instruments assessing PIU,time spent on Internet activities,and the level of psychological distress.Results:Model fits confirmed the(i)unidimensional structure of the GDT,BSMAS,SABAS,IGDS9-SF,(ii)two-factor structure of the GADIS-A,and(iii)four-factor structure of the NMP-Q.Additionally,the study found that different types of PIU were significantly associated with psychological distress and time spent on related Internet activities.Conclusion:The six instruments validated in the present study demonstrated very good to excellent psychometric properties when applied to university students in Ghana.The significant associations between Internet-related disorders,time spent on Internet-related activities,and psychological distress highlight the importance of addressing issues of PIU among this population.展开更多
Improving the quality of life for Earth's growing population is a complex task that requires the development of new technologies and materials. Perhaps the biggest challenge is access to clean and renewable energy...Improving the quality of life for Earth's growing population is a complex task that requires the development of new technologies and materials. Perhaps the biggest challenge is access to clean and renewable energy sources that can drive a sustainable future. Photovoltaics, today mainly represented by silicon-based solar cells, convert solar energy into electricity and is already an important component in the renewable energy portfolio.展开更多
Aqueous zinc-ion batteries(AZIBs)have garnered extensive attention as the promising energy storage technology owing to their high safety,cost-effectiveness,and environmental friendliness.Nevertheless,their practical a...Aqueous zinc-ion batteries(AZIBs)have garnered extensive attention as the promising energy storage technology owing to their high safety,cost-effectiveness,and environmental friendliness.Nevertheless,their practical application is hindered by critical challenges,including Hydrogen evolution reactions(HER)and non-uniform Zn deposition,which compromise electrochemical performance and cycling stability.Herein,we propose a multifunctional hybrid electrolyte additive consisting of vanillin and Dimethyl sulfoxide,designed to weaken the interaction between Zn^(2+)and H_(2)O molecules,effectively modulating the solvation shell structure.In situ optical microscopy shows the hybrid additive significantly suppresses HER and promotes Zn^(2+)deposition on the(002)plane,inhibiting dendritic growth.The Zn||Zn symmetric cells with hybrid additive exhibit exceptional cycling stability,achieving over 4000 h at 1.0 mA cm^(-2)/1.0 m A h cm^(-2).The research on hybrid additives presents significant potential for exploration,offering a promising approach to the development of durable AZIBs.展开更多
High-entropy alloys(HEAs)have emerged as promising catalysts for the hydrogen evolution reaction(HER)due to their compositional diversity and synergistic effects.In this study,machine learning-accelerated density func...High-entropy alloys(HEAs)have emerged as promising catalysts for the hydrogen evolution reaction(HER)due to their compositional diversity and synergistic effects.In this study,machine learning-accelerated density functional theory(DFT)calculations were employed to assess the catalytic performance of PtPd-based HEAs with the formula PtPdXYZ(X,Y,Z=Fe,Co,Ni,Cu,Ru,Rh,Ag,Au;X≠Y≠Z).Among 56 screened HEA(111)surfaces,PtPdRuCoNi(111)was identified as the most promising,with adsorption energies(E_(ads))between−0.50 and−0.60 eV and high d-band center of−1.85 eV,indicating enhanced activity.This surface showed the hydrogen adsorption free energy(ΔG_(H^(*)))of−0.03 eV for hydrogen adsorption,outperforming Pt(111)by achieving a better balance between adsorption and desorption.Machine learning models,particularly extreme gradient boosting regression(XGBR),significantly reduced computational costs while maintaining high accuracy(root-mean-square error,RMSE=0.128 eV).These results demonstrate the potential of HEAs for efficient and sustainable hydrogen production.展开更多
Zinc metal batteries(ZnBs)are poised as the next-generation energy storage solution,complementing lithium-ion batteries,thanks to their costeffectiveness and safety advantages.These benefits originate from the abundan...Zinc metal batteries(ZnBs)are poised as the next-generation energy storage solution,complementing lithium-ion batteries,thanks to their costeffectiveness and safety advantages.These benefits originate from the abundance of zinc and its compatibility with non-flammable aqueous electrolytes.However,the inherent instability of zinc in aqueous environments,manifested through hydrogen evolution reactions(HER)and dendritic growth,has hindered commercialization due to poor cycling stability.Enter potassium polyacrylate(PAAK)-based water-in-polymer salt electrolyte(WiPSE),a novel variant of water-in-salt electrolytes(WiSE),designed to mitigate side reactions associated with water redox processes,thereby enhancing the cyclic stability of ZnBs.In this study,WiPSE was employed in ZnBs featuring lignin and carbon composites as cathode materials.Our research highlights the crucial function of acrylate groups from WiPSE in stabilizing the ionic flux on the surface of the Zn electrode.This stabilization promotes the parallel deposition of Zn along the(002)plane,resulting in a significant reduction in dendritic growth.Notably,our sustainable Zn-lignin battery showcases remarkable cyclic stability,retaining 80%of its initial capacity after 8000 cycles at a high current rate(1 A g^(-1))and maintaining over 75%capacity retention up to 2000 cycles at a low current rate(0.2 A g^(-1)).This study showcases the practical application of WiPSE for the development of low-cost,dendrite-free,and scalable ZnBs.展开更多
The growing sophistication of cyberthreats,among others the Distributed Denial of Service attacks,has exposed limitations in traditional rule-based Security Information and Event Management systems.While machine learn...The growing sophistication of cyberthreats,among others the Distributed Denial of Service attacks,has exposed limitations in traditional rule-based Security Information and Event Management systems.While machine learning–based intrusion detection systems can capture complex network behaviours,their“black-box”nature often limits trust and actionable insight for security operators.This study introduces a novel approach that integrates Explainable Artificial Intelligence—xAI—with the Random Forest classifier to derive human-interpretable rules,thereby enhancing the detection of Distributed Denial of Service(DDoS)attacks.The proposed framework combines traditional static rule formulation with advanced xAI techniques—SHapley Additive exPlanations and Scoped Rules-to extract decision criteria from a fully trained model.The methodology was validated on two benchmark datasets,CICIDS2017 and WUSTL-IIOT-2021.Extracted rules were evaluated against conventional Security Information and Event Management Systems rules with metrics such as precision,recall,accuracy,balanced accuracy,and Matthews Correlation Coefficient.Experimental results demonstrate that xAI-derived rules consistently outperform traditional static rules.Notably,the most refined xAI-generated rule achieved near-perfect performance with significantly improved detection of DDoS traffic while maintaining high accuracy in classifying benign traffic across both datasets.展开更多
Copper complexes inspired by O_(2)-activating enzymes have been widely investigated as molecular water oxidation catalysts,capable of facile and reversible O─O bond formation and cleavage under mild conditions.In thi...Copper complexes inspired by O_(2)-activating enzymes have been widely investigated as molecular water oxidation catalysts,capable of facile and reversible O─O bond formation and cleavage under mild conditions.In this study,two copper phenanthroline complexes,namely,Cu(phen)and Cu(dophen),exhibit high turnover frequencies(TOFs)of 74±13 and(5.66±0.29)×10^(3)s^(−1)for water oxidation,respectively.Moreover,amino acid-functionalized carbon dots(CDs)were used to support the adhesion of the[Cu]complexes onto the electrode,significantly enhancing the TOFs of(2.80±0.12)×10^(3)and(4.11±0.24)×10^(4)s^(−1),respectively,exceeding the activity of photosystem Ⅱ in nature.Remarkably,the amino acid-functionalized CDs provide a secondary sphere that mimics the catalytic microenvironment of the copper centre,which promotes proton-coupled electron transfer and O─O bond formation.Finally,the photovoltaic-electrolysis(PVE)system was established using CDs-supported Cu catalysts and commercial silicon solar panels,achieving a high solar-to-hydrogen efficiency of 11.59%under the illumination of AM 1.5 G.This represents the most efficient solar-driven water splitting system based on copper-based catalysts to date,introducing the biomimetic secondary sphere to a“proton-rocking”process for water oxidation catalysis and application of the PVE system.展开更多
Introducing a stoichiometric excess of lead iodide(PbI_(2))in perovskite films has been demonstrated as an effective passivation strategy that can improve the power conversion efficiency(PCE)of perovskite solar cells(...Introducing a stoichiometric excess of lead iodide(PbI_(2))in perovskite films has been demonstrated as an effective passivation strategy that can improve the power conversion efficiency(PCE)of perovskite solar cells(PSCs),However,excess PbI_(2)is also known to accelerate the degradation of the perovskite layer.In this study,we show that this degradation primarily stems from the decomposition of PbI_(2)at the bottom of the perovskite film which is exposed to light We further show that when using a two-step spin coating deposition procedure,the excess PbI_(2)results from the decomposition of the perovskite during the annealing process rather than the presence of non-reacted PbI_(2).Finally,we demonstrate that the spatial distribution of PbI_(2)within the perovskite films can be controlled in a way that mitigates the PbI_(2)induced perovskite decomposition.In this manner,we produced devices exhibiting initial power conversion efficiencies over 25%,maintaining 98.6% after 1000 h of maximum power point tracking under continuous illumination.These findings offer valuable insights into achieving high performance PSCs through judicious process control using a two-step spin-coating procedure.展开更多
AIM: To determine if the severity of gastroesophageal reflux disease is dependent on the size of a hiatus hernia. METHODS: Seventy-five patients with either a small(n = 25), medium(n = 25) or large(n = 25) hiatus hern...AIM: To determine if the severity of gastroesophageal reflux disease is dependent on the size of a hiatus hernia. METHODS: Seventy-five patients with either a small(n = 25), medium(n = 25) or large(n = 25) hiatus hernia(assessed by high resolution esophageal manometry) were investigated using 24-h esophageal monitoring and a self-assessed symptom questionnaire. The questionnaire comprised the following items, each graded from 0 to 3 according to severity: heartburn; pharyngeal burning sensation; acid regurgitation; and chest pain. RESULTS: The percentage total reflux time was significantly longer in the group with hernia of 5 cm or more compared with the group with a hernia of < 3 cm(P < 0.002), and the group with a hernia of 3 to < 5 cm(P < 0.04). Pharyngeal burning sensation, heartburn and acid regurgitation were more common with large hernias than small hernias, but the frequency of chest pain was similar in all three hernia groups. CONCLUSION: Patients with a large hiatus hernia are more prone to have pathological gastroesophageal reflux and to have more acid symptoms than patients with a small hiatus hernia. However, it is unlikely that patients with an absence of acid symptoms will have pathological reflux regardless of hernia size.展开更多
AIM:To investigate whether nitrite administered prior to ischemia/reperfusion(I/R)reduces liver injury.METHODS:Thirty-six male Sprague-Dawley rats were randomized to 3 groups,including sham operated(n=8),45-min segmen...AIM:To investigate whether nitrite administered prior to ischemia/reperfusion(I/R)reduces liver injury.METHODS:Thirty-six male Sprague-Dawley rats were randomized to 3 groups,including sham operated(n=8),45-min segmental ischemia of the left liver lobe(IR,n=14)and ischemia/reperfusion(I/R)preceded by the administration of 480 nmol of nitrite(n=14).Serum transaminases were measured after 4 h of reperfusion.Liver microdialysate(MD)was sampled in 30-min intervals and analyzed for glucose,lactate,pyruvate and glycerol as well as the total nitrite and nitrate(NOx).The NOx was measured in serum.RESULTS:Aspartate aminotransferase(AST)at the end of reperfusion was higher in the IR group than in the nitrite group(40±6.8μkat/L vs 22±2.6μkat/L,P=0.022).Similarly,alanine aminotransferase(ALT)was also higher in the I/R group than in the nitrite group(34±6μkat vs 14±1.5μkat,P=0.0045).The NOx in MD was significantly higher in the nitrite group than in the I/R group(10.1±2.9μmol/L vs 3.2±0.9μmol/L,P=0.031)after the administration of nitrite.During ischemia,the levels decreased in both groups and then increased again during reperfusion.At the end of reperfusion,there was a tendency towards a higher NOx in the I/R group than in the nitrite group(11.6±0.7μmol/L vs 9.2±1.1μmol/L,P=0.067).Lactate in MD was significantly higher in the IR group than in the nitrite group(3.37±0.18 mmol/L vs 2.8±0.12 mmol/L,P=0.01)during ischemia and the first 30 min of reperfusion.During the same period,glycerol was also higher in the IRI group than in the nitrite group(464±38μmol/L vs 367±31μmol/L,P=0.049).With respect to histology,there were more signs of tissue damage in the I/R group than in the nitrite group,and29%of the animals in the I/R group exhibited necrosis compared with none in the nitrite group.Inducible nitric oxide synthase transcription increased between early ischemia(t=15)and the end of reperfusion in both groups.CONCLUSION:Nitrite administered before liver ischemia in the rat liver reduces anaerobic metabolism and cell necrosis,which could be important in the clinical setting.展开更多
AIM:To study the effects of preconditioning on inducible nitric oxide synthase(iNOS)and interleukin 1(IL-1)receptor transcription in rat liver ischemia/reperfusion injury(IRI).METHODS:Seventy-two male rats were random...AIM:To study the effects of preconditioning on inducible nitric oxide synthase(iNOS)and interleukin 1(IL-1)receptor transcription in rat liver ischemia/reperfusion injury(IRI).METHODS:Seventy-two male rats were randomized into 3 groups:the one-hour segmental ischemia(IRI,n=24)group,the ischemic preconditioning(IPC,n=24)group or the remote ischemic preconditioning(RIPC,n=24)group.The IPC and R-IPC were performed as 10 min of ischemia and 10 min of reperfusion.The iNOS and the IL-1 receptor mRNA in the liver tissue was analyzed with real time PCR.The total Nitrite and Nitrate(NOx)in continuously sampled microdialysate(MD)from the liver was analyzed.In addition,the NOx levels in the serum were analyzed.RESULTS:After 4 h of reperfusion,the iNOS mRNA was significantly higher in the R-IPC(ΔCt:3.44±0.57)group than in the IPC(ΔCt:5.86±0.82)group(P=0.025).The IL-1 receptor transcription activity was reduced in the IPC group(ΔCt:1.88±0.53 to 4.81±0.21),but not in the R-IPC group,during reperfusion(P=0.027).In the MD,a significant drop in the NOx levels was noted in the R-IPC group(12.3±2.2 to 4.7±1.2μmol/L)at the end of ischemia compared with the levels in early ischemia(P=0.008).A similar trend was observed in the IPC group(11.8±2.1 to 6.4±1.5μmol/L),although this difference was not statistically significant.The levels of NOx rose quickly during reperfusion in both groups.CONCLUSION:IPC,but not R-IPC,reduces iNOS and IL-1 receptor transcription during early reperfusion,indicating a lower inflammatory reaction.NOx is consumed in the ischemic liver lobe.展开更多
In order to explicit the environmental activity of heavy metals affected by different organic acids in soil,a batch incubation experiment was explored to investigate the influence of high relative molecular mass organ...In order to explicit the environmental activity of heavy metals affected by different organic acids in soil,a batch incubation experiment was explored to investigate the influence of high relative molecular mass organic acid(HMWOA)(humic acid and fulvic acid)and low relative molecular mass organic acid(LMWOA)(threonic acid and oxalic acid)on the release or immobilization of Pb,Cu and Cd in soils.Results showed that LMWOA,especially threonic acid,had a good performance in the release of Pb,Cu and Cd from soils,and decrease in the fractions of HOAc-extractable,reducible and oxidable Pb,Cu and Cd.Conversely,HMWOA,especially humic acid,decreased the release of Pb,Cu and Cd,while it increased the fractions of HOAc-extractable,reducible and oxidable Pb,Cu and Cd,indicating that HMWOA can immobilize heavy metals.The release of Pb,Cu and Cd caused by LMWOA was attributed to the dissociation of soil organic matter and amorphous iron oxides since the total organic carbon and the water-soluble iron increased.The immobilization of Pb,Cu and Cd by HMWOA was attributed to the adsorption onto HMWOA followed by amorphous iron since HMWOA resulted in a significant decrease of zeta potential and an increase of amorphous iron oxide.It can be concluded that LMWOA has a potential application in soil washing remediation,while HMWOA can be used in the immobilization remediation for heavy metals contaminated soils.展开更多
Non-alcoholic fatty liver disease(NAFLD),which has a global prevalence of 20%–33%,has become the main cause of chronic liver disease.Except for lifestyle medication,no definitive medical treatment has been establishe...Non-alcoholic fatty liver disease(NAFLD),which has a global prevalence of 20%–33%,has become the main cause of chronic liver disease.Except for lifestyle medication,no definitive medical treatment has been established so far,making it urgent to find effective strategies for the treatment of NAFLD.With the identification of the significant role played by the gut microbiota in the pathogenesis of NAFLD,studies on probiotics for the prevention and treatment of NAFLD are increasing in number.Bacteria from the Bifidobacterium and Lactobacillus genera constitute the most widely used traditional probiotics.More recently,emerging next-generation probiotics(NGPs)such as Akkermansia muciniphila and Faecalibacterium prausnitzii have also gained attention due to their potential as therapeutic options for the treatment of NAFLD.This review provides an overview of the effects of oral administration of traditional probiotics and NGPs on the development and progress of NAFLD.The mechanisms by which probiotics directly or indirectly affect the disease are illustrated,based on the most recent animal and clinical studies.Although numerous studies have been published on this topic,further research is required to comprehensively understand the specific underlying mechanisms among probiotics,gut microbiota,and NAFLD,and additional large-scale clinical trials are required to evaluate the therapeutic efficacy of probiotics for the treatment of NAFLD,as well as the safety of probiotics in the human body.展开更多
Dislocation plays a crucial role in controlling the strength and plasticity of bulk materials.However,determining the densities of geometrically necessary dislocations(GNDs)and statistically stored dislocations(SSDs)i...Dislocation plays a crucial role in controlling the strength and plasticity of bulk materials.However,determining the densities of geometrically necessary dislocations(GNDs)and statistically stored dislocations(SSDs)is one of the classical problems in material research for several decades.Here,we proposed a new approach based on indentation size effect(ISE)and strengthening theories.This approach was performed on a laser powder bed fused(L-PBF)Hastelloy X(HX),and the results were verified by the Hough-based EBSD and modified Williamson-Hall(m-WH)methods.Furthermore,to better understand the new approach and essential mechanisms,an in-depth investigation of the microstructure was conducted.The distribution of dislocations shows a clear grain orientation-dependent:low density in large<101>preferentially orientated grains while high density in fine<001>orientated grains.The increment of strengthening in L-PBF HX is attributed to a huge amount of edge-GNDs.Planar slip is the main operative deformation mechanism during indentation tests,and the slip step patterns depend mostly on grain orientations and stacking fault energy.This study provides quantitative results of GND and SSD density for L-PBF HX,which constructs a firm basis for future quantitative work on other metals with different crystal structures.展开更多
The void formation and plastic deformation micromechanisms of a cold-rolled DP600 steel during tensile loading were studied by scanning electron microscopy(SEM) and electron backscatter diffraction(EBSD).The SEM obser...The void formation and plastic deformation micromechanisms of a cold-rolled DP600 steel during tensile loading were studied by scanning electron microscopy(SEM) and electron backscatter diffraction(EBSD).The SEM observations revealed that the main void nucleation mechanism in the DP600 steel is decohesion at the ferrite-martensite interfaces.The voids were mostly observed between the closely spaced martensite islands situated at the boundaries of relatively finer ferrite grains.The EBSD results indicated a strain gradient developed from the ferrite-martensite and ferrite-ferrite interfaces into the interior of ferrite grains during the tensile deformation,which led to a stress concentration at these interfaces.Moreover,it was demonstrated that local misorientation inside the finer ferrite grains surrounded by martensite islands was higher than that for the coarser ferrite grains,which made the former more prone to void initiation.展开更多
BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of ...BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients.展开更多
The tremendous amount of wasted heat from solar radiation and industry dissipation has motivated the development of thermoelectric concepts that directly convert heat into electricity.The main challenge in practical a...The tremendous amount of wasted heat from solar radiation and industry dissipation has motivated the development of thermoelectric concepts that directly convert heat into electricity.The main challenge in practical applications for thermoelectrics is the high cost from both materials and manufacturing.Recently,breakthrough progresses in ionic thermoelectrics open up new possibilities to charge energy storage devices when submitted to a temperature gradient.The charging voltage is internally from the ionic Seebeck effect of the electrolyte between two electrodes.Hence electrolytes with high thermoelectric figure of merit are classified as ionic thermoelectric materials.Most ionic thermoelectric materials are composed of abundant elements,and they can generate hundreds of times larger thermal voltage than that of electronic materials.This emerging thermoelectric category brings new hope to fabricate low cost and large area heat-to-energy conversion devices,and triggers a renewed interest for ionic thermodiffusion.In this review,we summarize the state of the art in the new field of ionic thermoelectrics,from the driving force of the ionic thermodiffusion to material and application developments.We present a general map of ionic thermoelectric materials,discuss the unique characters of each type of the reported electrolytes,and propose potential optimization and future topics of ionic thermoelectrics.展开更多
文摘Doping is essential for modulating semiconductor conductivity,forming p-n junctions,and reducing contact resistance[1].Notably,as organic semiconductors(OSCs)advance toward high performance,flexibility,and miniaturization,achieving precise regionally selective doping becomes critical for building complex,highly integrated devices[2].In inorganic semiconductors(e.g.,silicon),sub-100-nanometer regional doping is achievable through photolithography and ion implantation—techniques foundational to modern complementary metaloxide-semiconductor(CMOS)technology[3].
基金supported by the National Natural Science Foundation of China(52171033,52431003,U23A20574)the Fundamental Research Funds for the Central Universities(2242025K20004)the SEU Innovation Capability Enhancement Plan for Doctoral Students(CXJH_SEU 24148,CXJH_SEU 25036).
文摘Microwave absorption(MA)materials often face poor synergy between impedance matching and attenuation in the low-frequency range.Balancing permittivity and permeability through magnetic-dielectric synergy is a promising strategy to address this issue.To realize the synergy,herein,Sn whiskers with an in situ oxide layer served as substrates for magnetic-loss-active CoNi nanosheet growth,forming a hierarchical CoNi@SnO_(2)@Sn(CNS)heterostructure.The CNS absorber achieves a minimum reflection loss(RL_(min))value of-62.29 dB with an effective absorption bandwidth(EAB)of 2.2 GHz,covering the entire C-band with 70%absorption at only 2.61 mm thickness.The nanosheet design of CoNi enhances magnetic anisotropy to promote natural resonance,while the conductive Sn core and abundant Sn/SnO_(2) and CoNi/SnO_(2) heterointerfaces facilitate conduction loss and dielectric polarization.When composited into a thermoplastic polyurethane(TPU)matrix,the resulting CNS/TPU-2 film(20 wt%CNS)exhibits an RL_(min) value of-61.04 dB and a 2.5 GHz EAB.Its in-plane and through-plane thermal conductivities reach 2.41 and 0.51 W m^(-1) K^(-1),representing 4.1 and 2.6 times those of pure TPU films,respectively,facilitating heat dissipation from protected devices.This work provides valuable insights into magnetic-dielectric synergy for low-frequency MA of 1D metal-based materials,offering promising potential for 5G communications and flexible electronics.
基金supported in part by Higher Education Sprout Project,Ministry of Education to the Headquarters of University Advancement at National Cheng Kung University(NCKU)supported in part by(received funding from)the National Science and Technology Council,Taiwan(NSTC 112-2410-H-006-089-SS2).
文摘Background:The present study evaluated the psychometric properties of Problematic Internet Use(PIU)instruments and their correlation with psychological distress and time spent on Internet activities among university students in Ghana.Methods:In the present cross-sectional survey design study,520 participants(35.96% female)were recruited with a mean age of 19.55 years(SD=1.94)from several university departments(i.e.,Behavioral Sciences,Materials Engineering,Nursing and Midwifery,and Biochemistry and Biotechnology)of Kwame Nkrumah University of Science and Technology(KNUST)between 19 July and 04 August,2023.Participants completed a survey that included the following measures:the Gaming Disorder Test(GDT),Gaming Disorder Scale for Adolescents(GADIS-A),Internet Gaming Disorder Scale-Short Form(IGDS9-SF),Bergen Social Media Addiction Scale(BSMAS),Smartphone Application Based Addiction Scale(SABAS),Nomophobia Questionnaire(NMP-Q),and the external criterion measure:Depression Anxiety Stress Scale-21(DASS-21).Confirmatory factor analysis(CFA)was carried out to evaluate the structure of the instruments.Cronbach’s α,McDonald’s ω,and composite reliability were used to evaluate internal consistency.Pearson correlation was used to examine the associations between the scores of instruments assessing PIU,time spent on Internet activities,and the level of psychological distress.Results:Model fits confirmed the(i)unidimensional structure of the GDT,BSMAS,SABAS,IGDS9-SF,(ii)two-factor structure of the GADIS-A,and(iii)four-factor structure of the NMP-Q.Additionally,the study found that different types of PIU were significantly associated with psychological distress and time spent on related Internet activities.Conclusion:The six instruments validated in the present study demonstrated very good to excellent psychometric properties when applied to university students in Ghana.The significant associations between Internet-related disorders,time spent on Internet-related activities,and psychological distress highlight the importance of addressing issues of PIU among this population.
基金financially supported by the National Science Foundation of China grant (62322407, 22279034, 52261145698, W2421103)Shanghai Science and Technology Innovation Action Plan (22ZR1418900, 24110714100)+1 种基金the Swedish Research Council (project grant no. 2020-04538)the Swedish Government Strategic Research Area in Materials Science on Functional Materials at Link?ping University (Faculty Grant SFO Mat LiU no. 2009 00971)。
文摘Improving the quality of life for Earth's growing population is a complex task that requires the development of new technologies and materials. Perhaps the biggest challenge is access to clean and renewable energy sources that can drive a sustainable future. Photovoltaics, today mainly represented by silicon-based solar cells, convert solar energy into electricity and is already an important component in the renewable energy portfolio.
基金supported by the National Natural Science Foundation of China(52402247)the Innovative Funds Plan of Henan University of Technology(2020ZKCJ07)+1 种基金the Cultivation Project of Tuoxin Team in Henan University of Technology(2024TXTD14)the Doctoral Fund of Henan University of Technology(31401577)。
文摘Aqueous zinc-ion batteries(AZIBs)have garnered extensive attention as the promising energy storage technology owing to their high safety,cost-effectiveness,and environmental friendliness.Nevertheless,their practical application is hindered by critical challenges,including Hydrogen evolution reactions(HER)and non-uniform Zn deposition,which compromise electrochemical performance and cycling stability.Herein,we propose a multifunctional hybrid electrolyte additive consisting of vanillin and Dimethyl sulfoxide,designed to weaken the interaction between Zn^(2+)and H_(2)O molecules,effectively modulating the solvation shell structure.In situ optical microscopy shows the hybrid additive significantly suppresses HER and promotes Zn^(2+)deposition on the(002)plane,inhibiting dendritic growth.The Zn||Zn symmetric cells with hybrid additive exhibit exceptional cycling stability,achieving over 4000 h at 1.0 mA cm^(-2)/1.0 m A h cm^(-2).The research on hybrid additives presents significant potential for exploration,offering a promising approach to the development of durable AZIBs.
基金the Second Century Fund(C2F),Chulalongkorn UniversityThailand Science Research and Innovation Fund Chulalongkorn University(No.IND_FF_68_054_2100_009)National Science and Technology Development Agency,Thailand,Hub of Knowledge funding,and the Mid-Career Research Grant 2024,National Research Council of Thailand(No.N42A670295).
文摘High-entropy alloys(HEAs)have emerged as promising catalysts for the hydrogen evolution reaction(HER)due to their compositional diversity and synergistic effects.In this study,machine learning-accelerated density functional theory(DFT)calculations were employed to assess the catalytic performance of PtPd-based HEAs with the formula PtPdXYZ(X,Y,Z=Fe,Co,Ni,Cu,Ru,Rh,Ag,Au;X≠Y≠Z).Among 56 screened HEA(111)surfaces,PtPdRuCoNi(111)was identified as the most promising,with adsorption energies(E_(ads))between−0.50 and−0.60 eV and high d-band center of−1.85 eV,indicating enhanced activity.This surface showed the hydrogen adsorption free energy(ΔG_(H^(*)))of−0.03 eV for hydrogen adsorption,outperforming Pt(111)by achieving a better balance between adsorption and desorption.Machine learning models,particularly extreme gradient boosting regression(XGBR),significantly reduced computational costs while maintaining high accuracy(root-mean-square error,RMSE=0.128 eV).These results demonstrate the potential of HEAs for efficient and sustainable hydrogen production.
基金primarily supported by the Proof-of-Concept project “high-voltage aqueous electrolytes (KAW 2020.0174)”the “Wood Wal enberg Science Center” funded by Knut and Alice Wal enberg (KAW) foundation+6 种基金supported by the Swedish Research Council (2016-05990)the Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-Li U No. 2009-00971)the competence center Fun Mat-II funded by the Swedish Agency for Innovation Systems (Vinnova, grant no 2016-05156)Aforsk foundation for the project “anode free Zn-ion battery (21-130)” and “Zn-lignin battery (22-134)”Swedish Electricity Storage and Balancing Centre (SESBC) funded by Energyimyndigghetenthe Swedish Research Council VR International Postdoc Grant 2022-00213“STand UP for energy col aboration and Swedish Research Council (2020-05223)”
文摘Zinc metal batteries(ZnBs)are poised as the next-generation energy storage solution,complementing lithium-ion batteries,thanks to their costeffectiveness and safety advantages.These benefits originate from the abundance of zinc and its compatibility with non-flammable aqueous electrolytes.However,the inherent instability of zinc in aqueous environments,manifested through hydrogen evolution reactions(HER)and dendritic growth,has hindered commercialization due to poor cycling stability.Enter potassium polyacrylate(PAAK)-based water-in-polymer salt electrolyte(WiPSE),a novel variant of water-in-salt electrolytes(WiSE),designed to mitigate side reactions associated with water redox processes,thereby enhancing the cyclic stability of ZnBs.In this study,WiPSE was employed in ZnBs featuring lignin and carbon composites as cathode materials.Our research highlights the crucial function of acrylate groups from WiPSE in stabilizing the ionic flux on the surface of the Zn electrode.This stabilization promotes the parallel deposition of Zn along the(002)plane,resulting in a significant reduction in dendritic growth.Notably,our sustainable Zn-lignin battery showcases remarkable cyclic stability,retaining 80%of its initial capacity after 8000 cycles at a high current rate(1 A g^(-1))and maintaining over 75%capacity retention up to 2000 cycles at a low current rate(0.2 A g^(-1)).This study showcases the practical application of WiPSE for the development of low-cost,dendrite-free,and scalable ZnBs.
基金funded under the Horizon Europe AI4CYBER Projectwhich has received funding from the European Union’s Horizon Europe Research and Innovation Programme under grant agreement No.101070450.
文摘The growing sophistication of cyberthreats,among others the Distributed Denial of Service attacks,has exposed limitations in traditional rule-based Security Information and Event Management systems.While machine learning–based intrusion detection systems can capture complex network behaviours,their“black-box”nature often limits trust and actionable insight for security operators.This study introduces a novel approach that integrates Explainable Artificial Intelligence—xAI—with the Random Forest classifier to derive human-interpretable rules,thereby enhancing the detection of Distributed Denial of Service(DDoS)attacks.The proposed framework combines traditional static rule formulation with advanced xAI techniques—SHapley Additive exPlanations and Scoped Rules-to extract decision criteria from a fully trained model.The methodology was validated on two benchmark datasets,CICIDS2017 and WUSTL-IIOT-2021.Extracted rules were evaluated against conventional Security Information and Event Management Systems rules with metrics such as precision,recall,accuracy,balanced accuracy,and Matthews Correlation Coefficient.Experimental results demonstrate that xAI-derived rules consistently outperform traditional static rules.Notably,the most refined xAI-generated rule achieved near-perfect performance with significantly improved detection of DDoS traffic while maintaining high accuracy in classifying benign traffic across both datasets.
基金supported by the National Natural Science Foundation of China(No.52273187)National Key R&D Program of China(2021YFA1500800)+1 种基金Guangdong Basic and Applied Basic Research Foundation(2022A1515110372,2023A1515011306,2023A1515240077)Guangdong-Hong Kong Joint Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province(2023B1212120011)。
文摘Copper complexes inspired by O_(2)-activating enzymes have been widely investigated as molecular water oxidation catalysts,capable of facile and reversible O─O bond formation and cleavage under mild conditions.In this study,two copper phenanthroline complexes,namely,Cu(phen)and Cu(dophen),exhibit high turnover frequencies(TOFs)of 74±13 and(5.66±0.29)×10^(3)s^(−1)for water oxidation,respectively.Moreover,amino acid-functionalized carbon dots(CDs)were used to support the adhesion of the[Cu]complexes onto the electrode,significantly enhancing the TOFs of(2.80±0.12)×10^(3)and(4.11±0.24)×10^(4)s^(−1),respectively,exceeding the activity of photosystem Ⅱ in nature.Remarkably,the amino acid-functionalized CDs provide a secondary sphere that mimics the catalytic microenvironment of the copper centre,which promotes proton-coupled electron transfer and O─O bond formation.Finally,the photovoltaic-electrolysis(PVE)system was established using CDs-supported Cu catalysts and commercial silicon solar panels,achieving a high solar-to-hydrogen efficiency of 11.59%under the illumination of AM 1.5 G.This represents the most efficient solar-driven water splitting system based on copper-based catalysts to date,introducing the biomimetic secondary sphere to a“proton-rocking”process for water oxidation catalysis and application of the PVE system.
基金funding support from the National Key R&D Program of China(2021YFF0501900)the Excellent Young Scholar Fund from the National Natural Science Foundation of China(22122903)+1 种基金the Tianjin Distinguished Young Scholar Fund(20JCJQJC00260)support from the Tianchi Talent Program of Xinjiang Uygur Autonomous Region。
文摘Introducing a stoichiometric excess of lead iodide(PbI_(2))in perovskite films has been demonstrated as an effective passivation strategy that can improve the power conversion efficiency(PCE)of perovskite solar cells(PSCs),However,excess PbI_(2)is also known to accelerate the degradation of the perovskite layer.In this study,we show that this degradation primarily stems from the decomposition of PbI_(2)at the bottom of the perovskite film which is exposed to light We further show that when using a two-step spin coating deposition procedure,the excess PbI_(2)results from the decomposition of the perovskite during the annealing process rather than the presence of non-reacted PbI_(2).Finally,we demonstrate that the spatial distribution of PbI_(2)within the perovskite films can be controlled in a way that mitigates the PbI_(2)induced perovskite decomposition.In this manner,we produced devices exhibiting initial power conversion efficiencies over 25%,maintaining 98.6% after 1000 h of maximum power point tracking under continuous illumination.These findings offer valuable insights into achieving high performance PSCs through judicious process control using a two-step spin-coating procedure.
文摘AIM: To determine if the severity of gastroesophageal reflux disease is dependent on the size of a hiatus hernia. METHODS: Seventy-five patients with either a small(n = 25), medium(n = 25) or large(n = 25) hiatus hernia(assessed by high resolution esophageal manometry) were investigated using 24-h esophageal monitoring and a self-assessed symptom questionnaire. The questionnaire comprised the following items, each graded from 0 to 3 according to severity: heartburn; pharyngeal burning sensation; acid regurgitation; and chest pain. RESULTS: The percentage total reflux time was significantly longer in the group with hernia of 5 cm or more compared with the group with a hernia of < 3 cm(P < 0.002), and the group with a hernia of 3 to < 5 cm(P < 0.04). Pharyngeal burning sensation, heartburn and acid regurgitation were more common with large hernias than small hernias, but the frequency of chest pain was similar in all three hernia groups. CONCLUSION: Patients with a large hiatus hernia are more prone to have pathological gastroesophageal reflux and to have more acid symptoms than patients with a small hiatus hernia. However, it is unlikely that patients with an absence of acid symptoms will have pathological reflux regardless of hernia size.
文摘AIM:To investigate whether nitrite administered prior to ischemia/reperfusion(I/R)reduces liver injury.METHODS:Thirty-six male Sprague-Dawley rats were randomized to 3 groups,including sham operated(n=8),45-min segmental ischemia of the left liver lobe(IR,n=14)and ischemia/reperfusion(I/R)preceded by the administration of 480 nmol of nitrite(n=14).Serum transaminases were measured after 4 h of reperfusion.Liver microdialysate(MD)was sampled in 30-min intervals and analyzed for glucose,lactate,pyruvate and glycerol as well as the total nitrite and nitrate(NOx).The NOx was measured in serum.RESULTS:Aspartate aminotransferase(AST)at the end of reperfusion was higher in the IR group than in the nitrite group(40±6.8μkat/L vs 22±2.6μkat/L,P=0.022).Similarly,alanine aminotransferase(ALT)was also higher in the I/R group than in the nitrite group(34±6μkat vs 14±1.5μkat,P=0.0045).The NOx in MD was significantly higher in the nitrite group than in the I/R group(10.1±2.9μmol/L vs 3.2±0.9μmol/L,P=0.031)after the administration of nitrite.During ischemia,the levels decreased in both groups and then increased again during reperfusion.At the end of reperfusion,there was a tendency towards a higher NOx in the I/R group than in the nitrite group(11.6±0.7μmol/L vs 9.2±1.1μmol/L,P=0.067).Lactate in MD was significantly higher in the IR group than in the nitrite group(3.37±0.18 mmol/L vs 2.8±0.12 mmol/L,P=0.01)during ischemia and the first 30 min of reperfusion.During the same period,glycerol was also higher in the IRI group than in the nitrite group(464±38μmol/L vs 367±31μmol/L,P=0.049).With respect to histology,there were more signs of tissue damage in the I/R group than in the nitrite group,and29%of the animals in the I/R group exhibited necrosis compared with none in the nitrite group.Inducible nitric oxide synthase transcription increased between early ischemia(t=15)and the end of reperfusion in both groups.CONCLUSION:Nitrite administered before liver ischemia in the rat liver reduces anaerobic metabolism and cell necrosis,which could be important in the clinical setting.
文摘AIM:To study the effects of preconditioning on inducible nitric oxide synthase(iNOS)and interleukin 1(IL-1)receptor transcription in rat liver ischemia/reperfusion injury(IRI).METHODS:Seventy-two male rats were randomized into 3 groups:the one-hour segmental ischemia(IRI,n=24)group,the ischemic preconditioning(IPC,n=24)group or the remote ischemic preconditioning(RIPC,n=24)group.The IPC and R-IPC were performed as 10 min of ischemia and 10 min of reperfusion.The iNOS and the IL-1 receptor mRNA in the liver tissue was analyzed with real time PCR.The total Nitrite and Nitrate(NOx)in continuously sampled microdialysate(MD)from the liver was analyzed.In addition,the NOx levels in the serum were analyzed.RESULTS:After 4 h of reperfusion,the iNOS mRNA was significantly higher in the R-IPC(ΔCt:3.44±0.57)group than in the IPC(ΔCt:5.86±0.82)group(P=0.025).The IL-1 receptor transcription activity was reduced in the IPC group(ΔCt:1.88±0.53 to 4.81±0.21),but not in the R-IPC group,during reperfusion(P=0.027).In the MD,a significant drop in the NOx levels was noted in the R-IPC group(12.3±2.2 to 4.7±1.2μmol/L)at the end of ischemia compared with the levels in early ischemia(P=0.008).A similar trend was observed in the IPC group(11.8±2.1 to 6.4±1.5μmol/L),although this difference was not statistically significant.The levels of NOx rose quickly during reperfusion in both groups.CONCLUSION:IPC,but not R-IPC,reduces iNOS and IL-1 receptor transcription during early reperfusion,indicating a lower inflammatory reaction.NOx is consumed in the ischemic liver lobe.
基金the financial supports from the National Natural Science Foundation of China(No.U20A20267)the National Key R&D Program of China(Nos.2020YFC1808002,2021YFC1809203)。
文摘In order to explicit the environmental activity of heavy metals affected by different organic acids in soil,a batch incubation experiment was explored to investigate the influence of high relative molecular mass organic acid(HMWOA)(humic acid and fulvic acid)and low relative molecular mass organic acid(LMWOA)(threonic acid and oxalic acid)on the release or immobilization of Pb,Cu and Cd in soils.Results showed that LMWOA,especially threonic acid,had a good performance in the release of Pb,Cu and Cd from soils,and decrease in the fractions of HOAc-extractable,reducible and oxidable Pb,Cu and Cd.Conversely,HMWOA,especially humic acid,decreased the release of Pb,Cu and Cd,while it increased the fractions of HOAc-extractable,reducible and oxidable Pb,Cu and Cd,indicating that HMWOA can immobilize heavy metals.The release of Pb,Cu and Cd caused by LMWOA was attributed to the dissociation of soil organic matter and amorphous iron oxides since the total organic carbon and the water-soluble iron increased.The immobilization of Pb,Cu and Cd by HMWOA was attributed to the adsorption onto HMWOA followed by amorphous iron since HMWOA resulted in a significant decrease of zeta potential and an increase of amorphous iron oxide.It can be concluded that LMWOA has a potential application in soil washing remediation,while HMWOA can be used in the immobilization remediation for heavy metals contaminated soils.
基金This study was supported by grants from the National Key Research and Development Program of China(2018YFC2000500)the National Natural Science Foundation of China(81790631 and 81330011).
文摘Non-alcoholic fatty liver disease(NAFLD),which has a global prevalence of 20%–33%,has become the main cause of chronic liver disease.Except for lifestyle medication,no definitive medical treatment has been established so far,making it urgent to find effective strategies for the treatment of NAFLD.With the identification of the significant role played by the gut microbiota in the pathogenesis of NAFLD,studies on probiotics for the prevention and treatment of NAFLD are increasing in number.Bacteria from the Bifidobacterium and Lactobacillus genera constitute the most widely used traditional probiotics.More recently,emerging next-generation probiotics(NGPs)such as Akkermansia muciniphila and Faecalibacterium prausnitzii have also gained attention due to their potential as therapeutic options for the treatment of NAFLD.This review provides an overview of the effects of oral administration of traditional probiotics and NGPs on the development and progress of NAFLD.The mechanisms by which probiotics directly or indirectly affect the disease are illustrated,based on the most recent animal and clinical studies.Although numerous studies have been published on this topic,further research is required to comprehensively understand the specific underlying mechanisms among probiotics,gut microbiota,and NAFLD,and additional large-scale clinical trials are required to evaluate the therapeutic efficacy of probiotics for the treatment of NAFLD,as well as the safety of probiotics in the human body.
基金supported by the Swedish Governmental Agency for Innovation Systems(Vinnova Grant No.2016-05175)the Center for Additive Manufacturing-metal(CAM2)。
文摘Dislocation plays a crucial role in controlling the strength and plasticity of bulk materials.However,determining the densities of geometrically necessary dislocations(GNDs)and statistically stored dislocations(SSDs)is one of the classical problems in material research for several decades.Here,we proposed a new approach based on indentation size effect(ISE)and strengthening theories.This approach was performed on a laser powder bed fused(L-PBF)Hastelloy X(HX),and the results were verified by the Hough-based EBSD and modified Williamson-Hall(m-WH)methods.Furthermore,to better understand the new approach and essential mechanisms,an in-depth investigation of the microstructure was conducted.The distribution of dislocations shows a clear grain orientation-dependent:low density in large<101>preferentially orientated grains while high density in fine<001>orientated grains.The increment of strengthening in L-PBF HX is attributed to a huge amount of edge-GNDs.Planar slip is the main operative deformation mechanism during indentation tests,and the slip step patterns depend mostly on grain orientations and stacking fault energy.This study provides quantitative results of GND and SSD density for L-PBF HX,which constructs a firm basis for future quantitative work on other metals with different crystal structures.
文摘The void formation and plastic deformation micromechanisms of a cold-rolled DP600 steel during tensile loading were studied by scanning electron microscopy(SEM) and electron backscatter diffraction(EBSD).The SEM observations revealed that the main void nucleation mechanism in the DP600 steel is decohesion at the ferrite-martensite interfaces.The voids were mostly observed between the closely spaced martensite islands situated at the boundaries of relatively finer ferrite grains.The EBSD results indicated a strain gradient developed from the ferrite-martensite and ferrite-ferrite interfaces into the interior of ferrite grains during the tensile deformation,which led to a stress concentration at these interfaces.Moreover,it was demonstrated that local misorientation inside the finer ferrite grains surrounded by martensite islands was higher than that for the coarser ferrite grains,which made the former more prone to void initiation.
基金Medical Research Council of Southeast Sweden(FORSS)and Division of Medical Diagnostics(Futurum),Region Jönköping County,Sweden.
文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients.
基金support by the French National Research Agency through grant ANR-19-CE300012by the European Research Council(ERC)through grant No.772725。
文摘The tremendous amount of wasted heat from solar radiation and industry dissipation has motivated the development of thermoelectric concepts that directly convert heat into electricity.The main challenge in practical applications for thermoelectrics is the high cost from both materials and manufacturing.Recently,breakthrough progresses in ionic thermoelectrics open up new possibilities to charge energy storage devices when submitted to a temperature gradient.The charging voltage is internally from the ionic Seebeck effect of the electrolyte between two electrodes.Hence electrolytes with high thermoelectric figure of merit are classified as ionic thermoelectric materials.Most ionic thermoelectric materials are composed of abundant elements,and they can generate hundreds of times larger thermal voltage than that of electronic materials.This emerging thermoelectric category brings new hope to fabricate low cost and large area heat-to-energy conversion devices,and triggers a renewed interest for ionic thermodiffusion.In this review,we summarize the state of the art in the new field of ionic thermoelectrics,from the driving force of the ionic thermodiffusion to material and application developments.We present a general map of ionic thermoelectric materials,discuss the unique characters of each type of the reported electrolytes,and propose potential optimization and future topics of ionic thermoelectrics.
