Psoriasis is a potentially debilitating inflammatory dermatosis affecting 0.2%-4.8% of the population worldwide causing a significant occupational, personal or psychosocial morbidity to these patients for life. The ba...Psoriasis is a potentially debilitating inflammatory dermatosis affecting 0.2%-4.8% of the population worldwide causing a significant occupational, personal or psychosocial morbidity to these patients for life. The basic aim of psoriasis therapy is to control the disease to maximum possible extent and improve the patient's quality of life. Management of triggers for flareups, lifestyle modifications, and dietary supplements are often recommended. Intermittent or rotational therapy with frequent alterations in treatment options is usually needed to reduce toxicity of anti-psoriatic drugs in the absence of safer alternatives. Currently, several biological agents categorized as either T-cell targeted(e.g., Alefacept, Efalizumab) or cytokine modulating(e.g., Adalimumab, Infliximab, Etanercept) are available for treating severe psoriasis. However, their high cost is often precluding for most patients. The usefulness of systemic(methotrexate, cyclosporine, acitretin or several other therapeutic agents) or topical(tar, anthralin, corticosteroids or calcipotriol ointments, phototherapy with or without psoralens) therapies has been well established for the management of psoriasis. The literature is also replete with benefits of less used non-standard and unconventional treatment modalities(hydroxycarbamide, azathioprine, leflunomide, mycophenolate mofetil, isotretinoin, fumarates, topical calcineurin inhibitors, peroxisome proliferator-activated receptors agonists, statins, sulfasalazine, pentoxifylline, colchicine, grenz ray therapy, excimer laser, climatotherapy and balneophototherapy, peritoneal dialysis, tonsillectomy, ichthyotherapy, etc.). These can be used alternatively to treat psoriasis patients who have mild/minimal lesions, are intolerant to conventional drugs, have developed side effects or achieved recommended cumulative dose, where comorbidities pose unusual therapeutic challenges, or may be as intermittent, rotational or combination treatment alternatives.展开更多
Let G be a finite group and H a subgroup of G.The normal index of H in G is defined as the order of K/H_(G),where K is a normal supplement of H in G such that|K|is minimal and H_(G)≤K■G.Let p be a prime which divide...Let G be a finite group and H a subgroup of G.The normal index of H in G is defined as the order of K/H_(G),where K is a normal supplement of H in G such that|K|is minimal and H_(G)≤K■G.Let p be a prime which divides the order of a group G.In this paper,some characterizations of G being p-solvable or p-supersolvable were obtained by analyzing the normal index of certain subgroups of G.These results can be viewed as local version of recent results in the literature.展开更多
In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizh...In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizhong Zhou,Hongxia Liu and Yang Xu(2022).Then,an A_(α)-spectral condition is given to ensure that G is a fractional ID-[a,b]-factor-critical covered graph and an(a,b,k)-factor-critical graph,respectively.In fact,(a,b,k)-factor-critical graph is a graph which has an[a,b]-factor for k=0.Thus,these above results extend the results of Jia Wei and Shenggui Zhang(2023)and Ao Fan,Ruifang Liu and Guoyan Ao(2023)in some sense.展开更多
The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and e...The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and existence of uniform attractor under some suitable assumptions on the nonlinear term g(u),the nonlinear damping f(u_(t))and the external force h(x,t).Specifically,the asymptotic compactness of the semigroup is verified by the energy reconstruction method.展开更多
Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery...Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery.We rst derive the projection formulas for a vector onto the feasible sets.The centralized circumcentered-reection method is designed to solve the convex feasibility problem.Some numerical experiments demonstrate the feasibility and e ectiveness of the proposed algorithm,showing superior performance compared to conventional alternating projection methods.展开更多
Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capa...Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capacity compared to olaparib.It is not affected by adenosine triphosphate(ATP)-binding cassette transporters.展开更多
Cloud computing has become an essential technology for the management and processing of large datasets,offering scalability,high availability,and fault tolerance.However,optimizing data replication across multiple dat...Cloud computing has become an essential technology for the management and processing of large datasets,offering scalability,high availability,and fault tolerance.However,optimizing data replication across multiple data centers poses a significant challenge,especially when balancing opposing goals such as latency,storage costs,energy consumption,and network efficiency.This study introduces a novel Dynamic Optimization Algorithm called Dynamic Multi-Objective Gannet Optimization(DMGO),designed to enhance data replication efficiency in cloud environments.Unlike traditional static replication systems,DMGO adapts dynamically to variations in network conditions,system demand,and resource availability.The approach utilizes multi-objective optimization approaches to efficiently balance data access latency,storage efficiency,and operational costs.DMGO consistently evaluates data center performance and adjusts replication algorithms in real time to guarantee optimal system efficiency.Experimental evaluations conducted in a simulated cloud environment demonstrate that DMGO significantly outperforms conventional static algorithms,achieving faster data access,lower storage overhead,reduced energy consumption,and improved scalability.The proposed methodology offers a robust and adaptable solution for modern cloud systems,ensuring efficient resource consumption while maintaining high performance.展开更多
BACKGROUND Solid pseudopapillary neoplasm(SPN)of the pancreas is a rare epithelial tumor that primarily affects young women.Since the condition is often asymptomatic or presents with non-specific symptoms,its diagnosi...BACKGROUND Solid pseudopapillary neoplasm(SPN)of the pancreas is a rare epithelial tumor that primarily affects young women.Since the condition is often asymptomatic or presents with non-specific symptoms,its diagnosis can be difficult.CASE SUMMARY This report details the case of a 15-year-old girl who presented with a 2-year history of abdominal pain,with no significant findings during physical examination.Abdominal ultrasound revealed a well-defined heterogeneous solidcystic mass in the epigastric region,likely originating from the tail of the pancreas.A subsequent contrast-enhanced computed tomography scan indicated a welldefined cystic lesion with an enhancing solid component and capsule in the tail of the pancreas,suggestive of a cystic neoplasm.The patient underwent an open distal pancreatectomy with splenectomy,and histopathological analysis confirmed the diagnosis of SPN of the pancreas.CONCLUSION This case highlights the risk of SPN in adolescent girls and the necessity of early diagnosis and intervention for better outcomes.展开更多
A species introduction experiment including several tropical pines and eucalypts was established in 1966/1967 in the Tchianga research station in Angolan Highlands. Despite 27 years of political conflict （1975-2002）...A species introduction experiment including several tropical pines and eucalypts was established in 1966/1967 in the Tchianga research station in Angolan Highlands. Despite 27 years of political conflict （1975-2002） and lack of management, the research experiment has remained relatively well conserved. We measured the best conserved plots that were 41 years old in 2007 to obtain information on the growth of different pine species. We calculated stand characteristics including basal area, dominant height, mean diameter, and stand volume for Pinus patula Schiede ex Schiltdl. Et Cham., Pinus pseudostrobus Lindl., Pinus kesiya Royle ex Gordon, Pinus devoniana Lindl., Pinus chiapensis （Martinez） Andresen, Pinus elliottii Engelm., Pinus greggii Engelm. Ex Parl., Pinus montezumae Lamb. and Pinus oocarpa Schiede ex Schltdl. The growing stock volume at 41 years was the highest in P. pseudostrobus, 1,325 m3^· ha^-1, followed by P. kesiya with 1,200 m^3· ha^-1. The widely planted P. patula had growing stock volume of 892 m^3· ha-^1. P. oocarpa and P. pseudostrobus had the highest stand basal area, over 80 m^2·ha^-1. Using increment core analyses we studied the temporal development of stand characteristics. Analysis of the mean annual increment （MAI） showed that rotation lengths of 20-30 years would maximize wood production. With these rotation lengths, the MAI of P. pseudostrobus would be 35 m^3· ha^-1. Other productive species were P. kesiya, P. ooearpa and P. chiapensis. P. patula had a maximum MAI of 20 m^3· ha^-1. P. greggii had the lowest mean annual volume production, only about 13 m^3· ha^-1.展开更多
Objective:To assess the distribution of ABO blood group and their relationship with Plasmodium falciparum(P.falciparum) malaria among febrile outpatients who sought medical attention at Dore Bafeno Health Center,South...Objective:To assess the distribution of ABO blood group and their relationship with Plasmodium falciparum(P.falciparum) malaria among febrile outpatients who sought medical attention at Dore Bafeno Health Center,Southern Ethiopia.Methods:A total of 269 febrile outpatients who visited Dore Bafeno Health Center,Southern Ethiopia,were examined for malaria and also tested for ABO blood groups in January 2010.The blood specimens were collected by finger pricking,stained with Geimsa,and examined microscopically.Positive cases of the parasitemia were counted.CareStart^(TM) Malaria PflPv Combo was also used to test the blood specimens for malaria.ABO blood groups were determined by agglutination test using ERYCLONE antisera.Data on socio-demographic characteristics and treatment status of the participants were also collected.Chi-square and ANOVA tests were used to assess the difference between frequencies and means,respectively.Results:Out of a total of 269 participants,178(66.2%) febrile patients were found to be infected with Plasmodium parasites,among which 146(54.3%),28(10.4%),and 4(1.5%) belonged to P.falciparum,P.vivax,and mixed infections,respectively.All febrile patients were also tested for ABO blood groups and 51.3%,23.5%,21.9%and 3.3%were found to be blood types of 0,A,B and AB,respectively.Both total malaria infection and P.falciparum infection showed significant association with blood types(P<0.05).The proportion of A or B but not 0 phenotypes was higher(P<0.05) in individuals with P.falciparum as compared with non-infected individuals.The chance of having P.falciparum infection in patients with blood groups A,B and AB was 2.5,2.5 and 3.3times more than individuals showing blood 0 phenotypes,respectively.The mean P.falciparum malaria parasitemia for blood groups A,B,AB,and 0 were 3 744/μ L,1 805/ μ L,5 331/μ L,and1 515/μ L,respectively(P<0.01).Conclusions:The present findings indicate that individuals of blood groups A,B and AB are more susceptible to P.falciparum infection as compared with individuals of blood group O.Nevertheless,further in depth studies are required to clearly establish the role that ABO blood group plays in P.falciparum malaria.展开更多
Conventional soil maps(CSMs)often have multiple soil types within a single polygon,which hinders the ability of machine learning to accurately predict soils.Soil disaggregation approaches are commonly used to improve ...Conventional soil maps(CSMs)often have multiple soil types within a single polygon,which hinders the ability of machine learning to accurately predict soils.Soil disaggregation approaches are commonly used to improve the spatial and attribute precision of CSMs.The approach disaggregation and harmonization of soil map units through resampled classification trees(DSMART)is popular but computationally intensive,as it generates and assigns synthetic samples to soil series based on the areal coverage information of CSMs.Alternatively,the disaggregation approach pure polygon disaggregation(PPD)assigns soil series based solely on the proportions of soil series in pure polygons in CSMs.This study compared these two disaggregation approaches by applying them to a CSM of Middlesex County,Ontario,Canada.Four different sampling methods were used:two sampling designs,simple random sampling(SRS)and conditional Latin hypercube sampling(cLHS),with two sample sizes(83100 and 19420 samples per sampling plan),both based on an area-weighted approach.Two machine learning algorithms(MLAs),C5.0 decision tree(C5.0)and random forest(RF),were applied to the disaggregation approaches to compare the disaggregation accuracy.The accuracy assessment utilized a set of 500 validation points obtained from the Middlesex County soil survey report.The MLA C5.0(Kappa index=0.58–0.63)showed better performance than RF(Kappa index=0.53–0.54)based on the larger sample size,and PPD with C5.0 based on the larger sample size was the best-performing(Kappa index=0.63)approach.Based on the smaller sample size,both cLHS(Kappa index=0.41–0.48)and SRS(Kappa index=0.40–0.47)produced similar accuracy results.The disaggregation approach PPD exhibited lower processing capacity and time demands(1.62–5.93 h)while yielding maps with lower uncertainty as compared to DSMART(2.75–194.2 h).For CSMs predominantly composed of pure polygons,utilizing PPD for soil series disaggregation is a more efficient and rational choice.However,DSMART is the preferable approach for disaggregating soil series that lack pure polygon representations in the CSMs.展开更多
The presence of heterozygous individuals in a population is crucial for maintaining genetic diversity,which can positively affect fitness and adaptability to environmental changes.While inbreeding generally reduces th...The presence of heterozygous individuals in a population is crucial for maintaining genetic diversity,which can positively affect fitness and adaptability to environmental changes.While inbreeding generally reduces the proportion of heterozygous individuals in a population,polyploidy tends to increase the proportion.North American Populus tremuloides is one of the most widely distributed and ecologically important tree species in the Northern Hemisphere.However,genetic variation in Mexican populations of P.tremuloides,including the genetic signatures of their adaptation to a variety of environments,remains largely uncharacterized.The aim of this study was to analyze how inbreeding coefficient(FIS)and ploidy are associated with clonal richness,population cover,climate and soil traits in 91 marginal to small,isolated populations of this tree species throughout its entire distribution in Mexico.Genetic variables were determined using 36,810 filtered SNPs derived from genome re-sequencing.We found that FIS was approximately between 0 and e1,indicating an extreme heterozygosity excess.One key contributor to the observed extreme heterozygosity excess was asexual reproduction,although ploidy levels cannot explain this excess.Analysis of all neutral SNPs showed that asexual reproduction was positively correlated with observed heterozygosity(Ho)but negatively correlated with expected heterozygosity(He).Analysis of outlier SNPs also showed that asexual reproductionwas positively correlated with Ho and negatively correlated with He,although this latter correlation was not significant.These findings support the presence of a Meselson effect.展开更多
Accurate quantification of life-cycle greenhouse gas(GHG)footprints(GHG_(fp))for a crop cultivation system is urgently needed to address the conflict between food security and global warming mitigation.In this study,t...Accurate quantification of life-cycle greenhouse gas(GHG)footprints(GHG_(fp))for a crop cultivation system is urgently needed to address the conflict between food security and global warming mitigation.In this study,the hydrobiogeochemical model,CNMM-DNDC,was validated with in situ observations from maize-based cultivation systems at the sites of Yongji(YJ,China),Yanting(YT,China),and Madeya(MA,Kenya),subject to temperate,subtropical,and tropical climates,respectively,and updated to enable life-cycle GHG_(fp)estimation.The model validation provided satisfactory simulations on multiple soil variables,crop growth,and emissions of GHGs and reactive nitrogen gases.The locally conventional management practices resulted in GHG_(fp)values of 0.35(0.09–0.53 at the 95%confidence interval),0.21(0.01–0.73),0.46(0.27–0.60),and 0.54(0.21–0.77)kg CO_(2)e kg~(-1)d.m.(d.m.for dry matter in short)for maize–wheat rotation at YJ and YT,and for maize–maize and maize–Tephrosia rotations at MA,respectively.YT's smallest GHG_(fp)was attributed to its lower off-farm GHG emissions than YJ,though the soil organic carbon(SOC)storage and maize yield were slightly lower than those of YJ.MA's highest SOC loss and low yield in shifting cultivation for maize–Tephrosia rotation contributed to its highest GHG_(fp).Management practices of maize cultivation at these sites could be optimized by combination of synthetic and organic fertilizer(s)while incorporating 50%–100%crop residues.Further evaluation of the updated CNMM-DNDC is needed for different crops at site and regional scales to confirm its worldwide applicability in quantifying GHG_(fp)and optimizing management practices for achieving multiple sustainability goals.展开更多
In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→...In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→∞)x′(t)e^(t)=0,where t_(0) and ψ_(0) are real constants,φ(s)=s/√1−s^(2),s∈R with s∈(−1,1),f:[t_(0),∞)×R→R satisfies the Lipschitz or Osgood-type conditions.展开更多
This paper investigates the following mixed local and nonlocal elliptic problem fea-turing concave-convex nonlinearities and a discontinuous right-hand side:{L(u)=H(u−μ)|u|^(p−2)u+λ|u|^(q−2)u,x∈Ω,u≥0,x∈Ω,u=0,x...This paper investigates the following mixed local and nonlocal elliptic problem fea-turing concave-convex nonlinearities and a discontinuous right-hand side:{L(u)=H(u−μ)|u|^(p−2)u+λ|u|^(q−2)u,x∈Ω,u≥0,x∈Ω,u=0,x∈R^(N)\Ω,where Ω R^(N)(N>2)is a bounded domain,μ≥0 and λ>0 are real parameters,H denotes the Heaviside function(H(t)=0 for t<0,H(t)=1 for t>0),and the mixed local and nolocal operator is defined as L(u)=−Δu+(−Δ)^(s)u with(−Δ)^(s) being the restricted fractional Laplace(0<s<1).The exponents satisfy 1<q<2<p.By employing a novel non-smooth variational principle,we establish the existence of an M-solution for this problem and identify a range for the exponent p.展开更多
In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random vari...In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random variables,and another is for sub-orthogonal random variables.Both extend the strong law of large numbers for independent random variables under sublinear expectations to the non-independent case.展开更多
AIM:To comparatively evaluate PCR and other diagnostic methods (the rapid urease test and/or culture) in order to determine which of the three PCR methods (ureA,glmM and 26-kDa,SSA gene) was most appropriate in the di...AIM:To comparatively evaluate PCR and other diagnostic methods (the rapid urease test and/or culture) in order to determine which of the three PCR methods (ureA,glmM and 26-kDa,SSA gene) was most appropriate in the diagnosis of Helicobacterpylori(Hpylori) infection and also to evaluate the detection of a putative virulence marker of H pylori,the cage,gene,by PCR in biopsy specimens. METHODS:One hundred and eighty-nine biopsy specimens were collected from 63 patients (three biopsies each) undergoing upper gastroduodenal endoscopy for various dyspeptic symptoms.The PCR methods used to detect H pylori DNA directly from biopsies were the glmM,26-kDa, ureA and then cagA was used to compare the culture technique and CLO for urease with the culture technique being used as the gold standard. RESULTS:Thirty-five percent of the biopsies were positive for H pylori DNA using the 3 PCR methods,while 68% of these were positive for the cagA gene.Twenty-four percent of the biopsies were negative for H pylori DNA in all PCR methods screened.The remaining 41% were either positive for ureA gene only,glmM only,26-kDa only,or ureA+glmM, ureA+26-kDa,glmM+26-kDa.Out of the 35% positive biopsies,41% and 82% were positive by culture and CLO respectively,while all negative biopsies were also negative by culture and cagA.Cag A+ infection was also predominantly found in H pylori DNA of the biopsies irrespective of the clinical diagnosis. CONCLUSION:This method is useful for correctly identifying infections caused by H pylori and can be easily applied in our laboratory for diagnostic purposes.展开更多
Long-life energy storage batteries are integral to energy storage systems and electric vehicles,with lithium-ion batteries(LIBs)currently being the preferred option for extended usage-life energy storage.To further ex...Long-life energy storage batteries are integral to energy storage systems and electric vehicles,with lithium-ion batteries(LIBs)currently being the preferred option for extended usage-life energy storage.To further extend the life span of LIBs,it is essential to intensify investments in battery design,manufacturing processes,and the advancement of ancillary materials.The pursuit of long durability introduces new challenges for battery energy density.The advent of electrode material offers effective support in enhancing the battery’s long-duration performance.Often underestimated as part of the cathode composition,the binder plays a pivotal role in the longevity and electrochemical performance of the electrode.Maintaining the mechanical integrity of the electrode through judicious binder design is a fundamental requirement for achieving consistent long-life cycles and high energy density.This paper primarily concentrates on the commonly employed cathode systems in lithium-ion batteries,elucidates the significance of binders for both,discusses the application status,strengths,and weaknesses of novel binders,and ultimately puts forth corresponding optimization strategies.It underscores the critical function of binders in enhancing battery performance and advancing the sustainable development of lithium-ion batteries,aiming to offer fresh insights and perspectives for the design of high-performance LIBs.展开更多
As modern power systems grow in complexity,accurate and efficient fault detection has become increasingly important.While many existing reviews focus on a single modality,this paper presents a comprehensive survey fro...As modern power systems grow in complexity,accurate and efficient fault detection has become increasingly important.While many existing reviews focus on a single modality,this paper presents a comprehensive survey from a dual-modality perspective-infrared imaging and voiceprint analysis-two complementary,non-contact techniques that capture different fault characteristics.Infrared imaging excels at detecting thermal anomalies,while voiceprint signals provide insight into mechanical vibrations and internal discharge phenomena.We review both traditional signal processing and deep learning-based approaches for each modality,categorized by key processing stages such as feature extraction and classification.The paper highlights how these modalities address distinct fault types and how they may be fused to improve robustness and accuracy.Representative datasets are summarized,and practical challenges such as noise interference,limited fault samples,and deployment constraints are discussed.By offering a cross-modal,comparative analysis,this work aims to bridge fragmented research and guide future development in intelligent fault detection systems.The review concludes with research trends including multimodal fusion,lightweight models,and self-supervised learning.展开更多
Fluorescent probes have revolutionized optical imaging and biosensing by enabling real-time visualization, quantification, and tracking of biological processes at molecular and cellular levels. These probes, ranging f...Fluorescent probes have revolutionized optical imaging and biosensing by enabling real-time visualization, quantification, and tracking of biological processes at molecular and cellular levels. These probes, ranging from organic dyes to genetically encoded proteins and nanomaterials, provide unparalleled specificity, sensitivity, and multiplexing capabilities. However, challenges such as brightness, photobleaching, biocompatibility, and emission range continue to drive innovation in probe design and application. This special issue, comprising four review papers and seven original research studies, highlights cutting-edge advancements in fluorescent probe technologies and their transformative roles in super-resolution imaging, in vivo diagnostics, and cancer therapeutics.展开更多
文摘Psoriasis is a potentially debilitating inflammatory dermatosis affecting 0.2%-4.8% of the population worldwide causing a significant occupational, personal or psychosocial morbidity to these patients for life. The basic aim of psoriasis therapy is to control the disease to maximum possible extent and improve the patient's quality of life. Management of triggers for flareups, lifestyle modifications, and dietary supplements are often recommended. Intermittent or rotational therapy with frequent alterations in treatment options is usually needed to reduce toxicity of anti-psoriatic drugs in the absence of safer alternatives. Currently, several biological agents categorized as either T-cell targeted(e.g., Alefacept, Efalizumab) or cytokine modulating(e.g., Adalimumab, Infliximab, Etanercept) are available for treating severe psoriasis. However, their high cost is often precluding for most patients. The usefulness of systemic(methotrexate, cyclosporine, acitretin or several other therapeutic agents) or topical(tar, anthralin, corticosteroids or calcipotriol ointments, phototherapy with or without psoralens) therapies has been well established for the management of psoriasis. The literature is also replete with benefits of less used non-standard and unconventional treatment modalities(hydroxycarbamide, azathioprine, leflunomide, mycophenolate mofetil, isotretinoin, fumarates, topical calcineurin inhibitors, peroxisome proliferator-activated receptors agonists, statins, sulfasalazine, pentoxifylline, colchicine, grenz ray therapy, excimer laser, climatotherapy and balneophototherapy, peritoneal dialysis, tonsillectomy, ichthyotherapy, etc.). These can be used alternatively to treat psoriasis patients who have mild/minimal lesions, are intolerant to conventional drugs, have developed side effects or achieved recommended cumulative dose, where comorbidities pose unusual therapeutic challenges, or may be as intermittent, rotational or combination treatment alternatives.
基金Supported by the National Natural Science Foundation of China(Grant No.12071092)Guangdong Basic and Applied Basic Research Foundation(Grant No.2025A1515012072)+1 种基金the Natural Science Research Project of Anhui Educational Committee(Grant No.2024AH051298)the Scientific Research Foundation of Bozhou University(Grant No.BYKQ202419).
文摘Let G be a finite group and H a subgroup of G.The normal index of H in G is defined as the order of K/H_(G),where K is a normal supplement of H in G such that|K|is minimal and H_(G)≤K■G.Let p be a prime which divides the order of a group G.In this paper,some characterizations of G being p-solvable or p-supersolvable were obtained by analyzing the normal index of certain subgroups of G.These results can be viewed as local version of recent results in the literature.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11961041,12261055)the Key Project of Natural Science Foundation of Gansu Province(Grant No.24JRRA222)the Foundation for Innovative Fundamental Research Group Project of Gansu Province(Grant No.25JRRA805).
文摘In this paper,we first give a sufficient condition for a graph being fractional ID-[a,b]-factor-critical covered in terms of its independence number and minimum degree,which partially answers the problem posed by Sizhong Zhou,Hongxia Liu and Yang Xu(2022).Then,an A_(α)-spectral condition is given to ensure that G is a fractional ID-[a,b]-factor-critical covered graph and an(a,b,k)-factor-critical graph,respectively.In fact,(a,b,k)-factor-critical graph is a graph which has an[a,b]-factor for k=0.Thus,these above results extend the results of Jia Wei and Shenggui Zhang(2023)and Ao Fan,Ruifang Liu and Guoyan Ao(2023)in some sense.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11961059,1210502)the University Innovation Project of Gansu Province(Grant No.2023B-062)the Gansu Province Basic Research Innovation Group Project(Grant No.23JRRA684).
文摘The goal of this paper is to investigate the long-time dynamics of solutions to a Kirchhoff type suspension bridge equation with nonlinear damping and memory term.For this problem we establish the well-posedness and existence of uniform attractor under some suitable assumptions on the nonlinear term g(u),the nonlinear damping f(u_(t))and the external force h(x,t).Specifically,the asymptotic compactness of the semigroup is verified by the energy reconstruction method.
基金Supported by the Natural Science Foundation of Guangxi Province(Grant Nos.2023GXNSFAA026067,2024GXN SFAA010521)the National Natural Science Foundation of China(Nos.12361079,12201149,12261026).
文摘Convex feasibility problems are widely used in image reconstruction,sparse signal recovery,and other areas.This paper is devoted to considering a class of convex feasibility problem arising from sparse signal recovery.We rst derive the projection formulas for a vector onto the feasible sets.The centralized circumcentered-reection method is designed to solve the convex feasibility problem.Some numerical experiments demonstrate the feasibility and e ectiveness of the proposed algorithm,showing superior performance compared to conventional alternating projection methods.
基金supported in part by funding from BeiGene,Ltd.,USA(Grant No.:KPR081)with additional support from the Alessandra Bono Foundation,Italy.
文摘Pamiparib is a potent and selective oral poly(adenosine diphosphate(ADP)-ribose)-polymerase(PARP)1/2inhibitor(PARPi).Pamiparib has good bioavailability and shows greater cytotoxic potency and similar DNA-trapping capacity compared to olaparib.It is not affected by adenosine triphosphate(ATP)-binding cassette transporters.
文摘Cloud computing has become an essential technology for the management and processing of large datasets,offering scalability,high availability,and fault tolerance.However,optimizing data replication across multiple data centers poses a significant challenge,especially when balancing opposing goals such as latency,storage costs,energy consumption,and network efficiency.This study introduces a novel Dynamic Optimization Algorithm called Dynamic Multi-Objective Gannet Optimization(DMGO),designed to enhance data replication efficiency in cloud environments.Unlike traditional static replication systems,DMGO adapts dynamically to variations in network conditions,system demand,and resource availability.The approach utilizes multi-objective optimization approaches to efficiently balance data access latency,storage efficiency,and operational costs.DMGO consistently evaluates data center performance and adjusts replication algorithms in real time to guarantee optimal system efficiency.Experimental evaluations conducted in a simulated cloud environment demonstrate that DMGO significantly outperforms conventional static algorithms,achieving faster data access,lower storage overhead,reduced energy consumption,and improved scalability.The proposed methodology offers a robust and adaptable solution for modern cloud systems,ensuring efficient resource consumption while maintaining high performance.
文摘BACKGROUND Solid pseudopapillary neoplasm(SPN)of the pancreas is a rare epithelial tumor that primarily affects young women.Since the condition is often asymptomatic or presents with non-specific symptoms,its diagnosis can be difficult.CASE SUMMARY This report details the case of a 15-year-old girl who presented with a 2-year history of abdominal pain,with no significant findings during physical examination.Abdominal ultrasound revealed a well-defined heterogeneous solidcystic mass in the epigastric region,likely originating from the tail of the pancreas.A subsequent contrast-enhanced computed tomography scan indicated a welldefined cystic lesion with an enhancing solid component and capsule in the tail of the pancreas,suggestive of a cystic neoplasm.The patient underwent an open distal pancreatectomy with splenectomy,and histopathological analysis confirmed the diagnosis of SPN of the pancreas.CONCLUSION This case highlights the risk of SPN in adolescent girls and the necessity of early diagnosis and intervention for better outcomes.
文摘A species introduction experiment including several tropical pines and eucalypts was established in 1966/1967 in the Tchianga research station in Angolan Highlands. Despite 27 years of political conflict （1975-2002） and lack of management, the research experiment has remained relatively well conserved. We measured the best conserved plots that were 41 years old in 2007 to obtain information on the growth of different pine species. We calculated stand characteristics including basal area, dominant height, mean diameter, and stand volume for Pinus patula Schiede ex Schiltdl. Et Cham., Pinus pseudostrobus Lindl., Pinus kesiya Royle ex Gordon, Pinus devoniana Lindl., Pinus chiapensis （Martinez） Andresen, Pinus elliottii Engelm., Pinus greggii Engelm. Ex Parl., Pinus montezumae Lamb. and Pinus oocarpa Schiede ex Schltdl. The growing stock volume at 41 years was the highest in P. pseudostrobus, 1,325 m3^· ha^-1, followed by P. kesiya with 1,200 m^3· ha^-1. The widely planted P. patula had growing stock volume of 892 m^3· ha-^1. P. oocarpa and P. pseudostrobus had the highest stand basal area, over 80 m^2·ha^-1. Using increment core analyses we studied the temporal development of stand characteristics. Analysis of the mean annual increment （MAI） showed that rotation lengths of 20-30 years would maximize wood production. With these rotation lengths, the MAI of P. pseudostrobus would be 35 m^3· ha^-1. Other productive species were P. kesiya, P. ooearpa and P. chiapensis. P. patula had a maximum MAI of 20 m^3· ha^-1. P. greggii had the lowest mean annual volume production, only about 13 m^3· ha^-1.
基金Supported by School of Graduate Studies through Aklilu LemmaInstitute of Pathobiology,Addis Ababa University(No:RDP/Py-014/09)
文摘Objective:To assess the distribution of ABO blood group and their relationship with Plasmodium falciparum(P.falciparum) malaria among febrile outpatients who sought medical attention at Dore Bafeno Health Center,Southern Ethiopia.Methods:A total of 269 febrile outpatients who visited Dore Bafeno Health Center,Southern Ethiopia,were examined for malaria and also tested for ABO blood groups in January 2010.The blood specimens were collected by finger pricking,stained with Geimsa,and examined microscopically.Positive cases of the parasitemia were counted.CareStart^(TM) Malaria PflPv Combo was also used to test the blood specimens for malaria.ABO blood groups were determined by agglutination test using ERYCLONE antisera.Data on socio-demographic characteristics and treatment status of the participants were also collected.Chi-square and ANOVA tests were used to assess the difference between frequencies and means,respectively.Results:Out of a total of 269 participants,178(66.2%) febrile patients were found to be infected with Plasmodium parasites,among which 146(54.3%),28(10.4%),and 4(1.5%) belonged to P.falciparum,P.vivax,and mixed infections,respectively.All febrile patients were also tested for ABO blood groups and 51.3%,23.5%,21.9%and 3.3%were found to be blood types of 0,A,B and AB,respectively.Both total malaria infection and P.falciparum infection showed significant association with blood types(P<0.05).The proportion of A or B but not 0 phenotypes was higher(P<0.05) in individuals with P.falciparum as compared with non-infected individuals.The chance of having P.falciparum infection in patients with blood groups A,B and AB was 2.5,2.5 and 3.3times more than individuals showing blood 0 phenotypes,respectively.The mean P.falciparum malaria parasitemia for blood groups A,B,AB,and 0 were 3 744/μ L,1 805/ μ L,5 331/μ L,and1 515/μ L,respectively(P<0.01).Conclusions:The present findings indicate that individuals of blood groups A,B and AB are more susceptible to P.falciparum infection as compared with individuals of blood group O.Nevertheless,further in depth studies are required to clearly establish the role that ABO blood group plays in P.falciparum malaria.
基金the Ontario Ministry of Agriculture,Food and Rural Affairs,Canada,who supported this project by providing updated soil information on Ontario and Middlesex Countysupported by the Natural Science and Engineering Research Council of Canada(No.RGPIN-2014-4100)。
文摘Conventional soil maps(CSMs)often have multiple soil types within a single polygon,which hinders the ability of machine learning to accurately predict soils.Soil disaggregation approaches are commonly used to improve the spatial and attribute precision of CSMs.The approach disaggregation and harmonization of soil map units through resampled classification trees(DSMART)is popular but computationally intensive,as it generates and assigns synthetic samples to soil series based on the areal coverage information of CSMs.Alternatively,the disaggregation approach pure polygon disaggregation(PPD)assigns soil series based solely on the proportions of soil series in pure polygons in CSMs.This study compared these two disaggregation approaches by applying them to a CSM of Middlesex County,Ontario,Canada.Four different sampling methods were used:two sampling designs,simple random sampling(SRS)and conditional Latin hypercube sampling(cLHS),with two sample sizes(83100 and 19420 samples per sampling plan),both based on an area-weighted approach.Two machine learning algorithms(MLAs),C5.0 decision tree(C5.0)and random forest(RF),were applied to the disaggregation approaches to compare the disaggregation accuracy.The accuracy assessment utilized a set of 500 validation points obtained from the Middlesex County soil survey report.The MLA C5.0(Kappa index=0.58–0.63)showed better performance than RF(Kappa index=0.53–0.54)based on the larger sample size,and PPD with C5.0 based on the larger sample size was the best-performing(Kappa index=0.63)approach.Based on the smaller sample size,both cLHS(Kappa index=0.41–0.48)and SRS(Kappa index=0.40–0.47)produced similar accuracy results.The disaggregation approach PPD exhibited lower processing capacity and time demands(1.62–5.93 h)while yielding maps with lower uncertainty as compared to DSMART(2.75–194.2 h).For CSMs predominantly composed of pure polygons,utilizing PPD for soil series disaggregation is a more efficient and rational choice.However,DSMART is the preferable approach for disaggregating soil series that lack pure polygon representations in the CSMs.
基金We thank the Mexican Consejo Nacional de Humanidades,Ciencias y Tecnologías(CONAHCYT)for the financial support provided to the first author to carry out his training in the Institutional Doctoral Program in Agricultural and Forestry Sciences(PIDCAFUJED)with Scholarship No.334852financial support with agreement number CONACYT-FRQ-2016:279459 for the project“Genome-wide scans for detecting adaptation to climate and soil in Populus tremuloides as the most widely distributed tree species in North America”Dr.Jesús M.Olivas-García assisted in the sampling in the state of Chihuahua,Mexico,and Katrin Groppe,Thünen Institute of Forest Genetics,Germany,provided excellent lab work.The Emerging Leaders of the Americas Program(ELAP)of the Government of Canada awarded a scholarship and the Institute of Integrative and Systems Biology(IBIS)of Laval University allowed the use of its campus and contributed to the training of the first author.
文摘The presence of heterozygous individuals in a population is crucial for maintaining genetic diversity,which can positively affect fitness and adaptability to environmental changes.While inbreeding generally reduces the proportion of heterozygous individuals in a population,polyploidy tends to increase the proportion.North American Populus tremuloides is one of the most widely distributed and ecologically important tree species in the Northern Hemisphere.However,genetic variation in Mexican populations of P.tremuloides,including the genetic signatures of their adaptation to a variety of environments,remains largely uncharacterized.The aim of this study was to analyze how inbreeding coefficient(FIS)and ploidy are associated with clonal richness,population cover,climate and soil traits in 91 marginal to small,isolated populations of this tree species throughout its entire distribution in Mexico.Genetic variables were determined using 36,810 filtered SNPs derived from genome re-sequencing.We found that FIS was approximately between 0 and e1,indicating an extreme heterozygosity excess.One key contributor to the observed extreme heterozygosity excess was asexual reproduction,although ploidy levels cannot explain this excess.Analysis of all neutral SNPs showed that asexual reproduction was positively correlated with observed heterozygosity(Ho)but negatively correlated with expected heterozygosity(He).Analysis of outlier SNPs also showed that asexual reproductionwas positively correlated with Ho and negatively correlated with He,although this latter correlation was not significant.These findings support the presence of a Meselson effect.
基金jointly supported by the National Key R&D Program of China(Grant No.2022YFE0209200)the National Natural Science Foundation of China(Grant Nos.U22A20562,42330607 and 41761144054)the National Large Scientific and Technological Infrastructure“Earth System Science Numerical Simulator Facility”(Earth-Lab)(https://cstr.cn/31134.02.EL)。
文摘Accurate quantification of life-cycle greenhouse gas(GHG)footprints(GHG_(fp))for a crop cultivation system is urgently needed to address the conflict between food security and global warming mitigation.In this study,the hydrobiogeochemical model,CNMM-DNDC,was validated with in situ observations from maize-based cultivation systems at the sites of Yongji(YJ,China),Yanting(YT,China),and Madeya(MA,Kenya),subject to temperate,subtropical,and tropical climates,respectively,and updated to enable life-cycle GHG_(fp)estimation.The model validation provided satisfactory simulations on multiple soil variables,crop growth,and emissions of GHGs and reactive nitrogen gases.The locally conventional management practices resulted in GHG_(fp)values of 0.35(0.09–0.53 at the 95%confidence interval),0.21(0.01–0.73),0.46(0.27–0.60),and 0.54(0.21–0.77)kg CO_(2)e kg~(-1)d.m.(d.m.for dry matter in short)for maize–wheat rotation at YJ and YT,and for maize–maize and maize–Tephrosia rotations at MA,respectively.YT's smallest GHG_(fp)was attributed to its lower off-farm GHG emissions than YJ,though the soil organic carbon(SOC)storage and maize yield were slightly lower than those of YJ.MA's highest SOC loss and low yield in shifting cultivation for maize–Tephrosia rotation contributed to its highest GHG_(fp).Management practices of maize cultivation at these sites could be optimized by combination of synthetic and organic fertilizer(s)while incorporating 50%–100%crop residues.Further evaluation of the updated CNMM-DNDC is needed for different crops at site and regional scales to confirm its worldwide applicability in quantifying GHG_(fp)and optimizing management practices for achieving multiple sustainability goals.
基金Supported by the National Natural Science Foundation of China(Grant Nos.12361040,12061064)the Na-tional Science Foundation of Gansu Province(Grant No.22JR5RA264)State Scholarship Fund(Grant No.20230862021).
文摘In this article,we show the existence,uniqueness and stability of bounded solutions to the following quasilinear problems with mean curvature operator(φ'(x′(t)))′=f(t,x),t≥t_(0),lim_(t→∞)x(t)=ψ_(0),lim_(t→∞)x′(t)e^(t)=0,where t_(0) and ψ_(0) are real constants,φ(s)=s/√1−s^(2),s∈R with s∈(−1,1),f:[t_(0),∞)×R→R satisfies the Lipschitz or Osgood-type conditions.
基金Supported by the National Natural Science Foundation of China(Grant No.12361026)the Discipline Con-struction Fund Project of Northwest Minzu University.
文摘This paper investigates the following mixed local and nonlocal elliptic problem fea-turing concave-convex nonlinearities and a discontinuous right-hand side:{L(u)=H(u−μ)|u|^(p−2)u+λ|u|^(q−2)u,x∈Ω,u≥0,x∈Ω,u=0,x∈R^(N)\Ω,where Ω R^(N)(N>2)is a bounded domain,μ≥0 and λ>0 are real parameters,H denotes the Heaviside function(H(t)=0 for t<0,H(t)=1 for t>0),and the mixed local and nolocal operator is defined as L(u)=−Δu+(−Δ)^(s)u with(−Δ)^(s) being the restricted fractional Laplace(0<s<1).The exponents satisfy 1<q<2<p.By employing a novel non-smooth variational principle,we establish the existence of an M-solution for this problem and identify a range for the exponent p.
文摘In this paper,we establish some strong laws of large numbers,which are for nonindependent random variables under the framework of sublinear expectations.One of our main results is for blockwise m-dependent random variables,and another is for sub-orthogonal random variables.Both extend the strong law of large numbers for independent random variables under sublinear expectations to the non-independent case.
基金Supported by Inserm Fellowship,France,awarded to Dr.SI Smith
文摘AIM:To comparatively evaluate PCR and other diagnostic methods (the rapid urease test and/or culture) in order to determine which of the three PCR methods (ureA,glmM and 26-kDa,SSA gene) was most appropriate in the diagnosis of Helicobacterpylori(Hpylori) infection and also to evaluate the detection of a putative virulence marker of H pylori,the cage,gene,by PCR in biopsy specimens. METHODS:One hundred and eighty-nine biopsy specimens were collected from 63 patients (three biopsies each) undergoing upper gastroduodenal endoscopy for various dyspeptic symptoms.The PCR methods used to detect H pylori DNA directly from biopsies were the glmM,26-kDa, ureA and then cagA was used to compare the culture technique and CLO for urease with the culture technique being used as the gold standard. RESULTS:Thirty-five percent of the biopsies were positive for H pylori DNA using the 3 PCR methods,while 68% of these were positive for the cagA gene.Twenty-four percent of the biopsies were negative for H pylori DNA in all PCR methods screened.The remaining 41% were either positive for ureA gene only,glmM only,26-kDa only,or ureA+glmM, ureA+26-kDa,glmM+26-kDa.Out of the 35% positive biopsies,41% and 82% were positive by culture and CLO respectively,while all negative biopsies were also negative by culture and cagA.Cag A+ infection was also predominantly found in H pylori DNA of the biopsies irrespective of the clinical diagnosis. CONCLUSION:This method is useful for correctly identifying infections caused by H pylori and can be easily applied in our laboratory for diagnostic purposes.
基金We would like to show gratitude to the Yunnan Province Basic Research Major Project(202501BC070006(Y.Wang))Key Industry Science and Technology Projects for University Services in Yunnan Province(FWCY ZNT2024002(Y.Wang))+3 种基金National Natural Science Foundation of China(22279070(L.Wang))and(U21A20170(X.He))the Ministry of Science and Technology of China(2019YFA0705703(L.Wang))Beijing Natural Science Foundation(L242005(X.He))Key Industry Science and Technology Projects for University Services in Yunnan Province(FWCY BSPY2024011(T.Lai)).
文摘Long-life energy storage batteries are integral to energy storage systems and electric vehicles,with lithium-ion batteries(LIBs)currently being the preferred option for extended usage-life energy storage.To further extend the life span of LIBs,it is essential to intensify investments in battery design,manufacturing processes,and the advancement of ancillary materials.The pursuit of long durability introduces new challenges for battery energy density.The advent of electrode material offers effective support in enhancing the battery’s long-duration performance.Often underestimated as part of the cathode composition,the binder plays a pivotal role in the longevity and electrochemical performance of the electrode.Maintaining the mechanical integrity of the electrode through judicious binder design is a fundamental requirement for achieving consistent long-life cycles and high energy density.This paper primarily concentrates on the commonly employed cathode systems in lithium-ion batteries,elucidates the significance of binders for both,discusses the application status,strengths,and weaknesses of novel binders,and ultimately puts forth corresponding optimization strategies.It underscores the critical function of binders in enhancing battery performance and advancing the sustainable development of lithium-ion batteries,aiming to offer fresh insights and perspectives for the design of high-performance LIBs.
基金supported by Science and Technology Project of State Grid Corporation of China(52094024003D).
文摘As modern power systems grow in complexity,accurate and efficient fault detection has become increasingly important.While many existing reviews focus on a single modality,this paper presents a comprehensive survey from a dual-modality perspective-infrared imaging and voiceprint analysis-two complementary,non-contact techniques that capture different fault characteristics.Infrared imaging excels at detecting thermal anomalies,while voiceprint signals provide insight into mechanical vibrations and internal discharge phenomena.We review both traditional signal processing and deep learning-based approaches for each modality,categorized by key processing stages such as feature extraction and classification.The paper highlights how these modalities address distinct fault types and how they may be fused to improve robustness and accuracy.Representative datasets are summarized,and practical challenges such as noise interference,limited fault samples,and deployment constraints are discussed.By offering a cross-modal,comparative analysis,this work aims to bridge fragmented research and guide future development in intelligent fault detection systems.The review concludes with research trends including multimodal fusion,lightweight models,and self-supervised learning.
文摘Fluorescent probes have revolutionized optical imaging and biosensing by enabling real-time visualization, quantification, and tracking of biological processes at molecular and cellular levels. These probes, ranging from organic dyes to genetically encoded proteins and nanomaterials, provide unparalleled specificity, sensitivity, and multiplexing capabilities. However, challenges such as brightness, photobleaching, biocompatibility, and emission range continue to drive innovation in probe design and application. This special issue, comprising four review papers and seven original research studies, highlights cutting-edge advancements in fluorescent probe technologies and their transformative roles in super-resolution imaging, in vivo diagnostics, and cancer therapeutics.
