Urban agenda nowadays puts pedestrians as the axis of urban design, and pedestrians are the most important thing in the city. The architect takes that idea and applies it in the project, and he focuses on prioritizing...Urban agenda nowadays puts pedestrians as the axis of urban design, and pedestrians are the most important thing in the city. The architect takes that idea and applies it in the project, and he focuses on prioritizing the pedestrian over the cars. Public spaces filled with green zones are a main element, water treatment is a design determinant, buildings use natural illumination as much as possible and culture and arts are reinforced through new scenarios.展开更多
Ouricuri endocarp was utilized as a biosorbent for the recovery of europium(Eu(Ⅲ))from aqueous solutions and rare earth elements(REEs)from authentic leachate derived from phosphogypsum,which encompasses various REEs....Ouricuri endocarp was utilized as a biosorbent for the recovery of europium(Eu(Ⅲ))from aqueous solutions and rare earth elements(REEs)from authentic leachate derived from phosphogypsum,which encompasses various REEs.Various characterization techniques were applied to analyze the physicochemical and adsorptive properties of the biosorbent.The results indicate that the adsorption kinetic data conform well to the pseudo-first-order model,while the Liu model describes the equilibrium data well.Ouricuri endocarp and Eu interactions are favorable and spontaneous.The maximum adsorption capacity for Eu(Ⅲ)is determined to be 22.9 mg/g according to the Liu model.Based on experimental results and adsorbent characteristics,the proposed adsorption mechanisms between ouricuri endocarp and Eu include ion exchange and electrostatic interactions as the primary mechanisms.The Eu(Ⅲ)recovery is also feasible as a continuous flow process demonstrating inclined breakthrough curves and lower values of the length of the mass transfer zone.Ouricuri endocarp demonstrates its selectivity for recovering various REEs from authentic phosphogypsum leachate.It achieves a 98%recovery rate for Eu and approximately 60%for Ce,La,and Nd,affirming its efficacy under real-world conditions.Finally,concentration of REE was done by ashing loaded ouricuri endocarp,and a solid with around 34%(in weight)of REE is obtained.展开更多
Deterioration of air quality due to the increase in atmospheric emissions from biomass burning(BB)is one of the major environmental problems worldwide.In this study,we estimated the contributions of BB to PM_(2.5) con...Deterioration of air quality due to the increase in atmospheric emissions from biomass burning(BB)is one of the major environmental problems worldwide.In this study,we estimated the contributions of BB to PM_(2.5) concentrations in the municipalities of Soledad and Malambo located in the Colombian Caribbean.The evaluation period ranged from February 24 to March 30,2018,a period with a high number of BB events recorded in the surroundings of the evaluated sites.The contribution of BB to the two sampling sites was estimated using the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)dispersion model with forwarding trajectories from each of the burning points identified by satellite images(n=1089).The PM_(2.5) emissions were determined using the fire radiative power(FRP),obtained by remote-sensing data,and corresponded to the radiant energy released per time unit by burning vegetation.The average PM_(2.5) concentrations during the evaluation period were 19.91μg/m^(3) for Soledad and 22.44μg/m^(3) for Malambo.The average contribution of BB to these municipalities was 22.8%and 28.8%,respectively.The methodology used in this study allowed to estimate the contribution of this important source without knowledge of a previous tracer of BB,thereby increasing the use of the proposed procedure worldwide.This information would enable the implementation of effective mitigation,thereby diminishing the adverse impact of PM_(2.5) on the health of the population.展开更多
Air pollution by particulate matter(PM)is one of the main threats to human health,particularly in large cities where pollution levels are continually exceeded.According to their source of emission,geography,and local ...Air pollution by particulate matter(PM)is one of the main threats to human health,particularly in large cities where pollution levels are continually exceeded.According to their source of emission,geography,and local meteorology,the pollutant particles vary in size and composition.These particles are conditioned to the aerodynamic diameter and thus classified as coarse(2.5–10μm),fine(0.1–2.5μm),and ultrafine(<0.1μm),where the degree of toxicity becomes greater for smaller particles.These particles can get into the lungs and translocate into vital organs due to their size,causing significant human health consequences.Besides,PM pollutants have been linked to respiratory conditions,genotoxic,mutagenic,and carcinogenic activity in human beings.This paper presents an overview of emission sources,physicochemical characteristics,collection and measurement methodologies,toxicity,and existing control mechanisms for ultrafine particles(UFPs)in the last fifteen years.展开更多
Air pollution has become a critical issue in urban areas,so a broad understanding of its spatiotemporal characteristics is important to develop public policies.This study analyzes the spatiotemporal variation of atmos...Air pollution has become a critical issue in urban areas,so a broad understanding of its spatiotemporal characteristics is important to develop public policies.This study analyzes the spatiotemporal variation of atmospheric particulate matter(PM_(10) and PM_(2.5))and ozone(O_(3))in Barranquilla,Colombia from March 2018 to June 2019 in three monitoring stations.The average concentrations observed for the Móvil,Policía,and Tres Avemarías stations,respectively,for PM_(10):46.4,51.4,and 39.7μg/m^(3);for PM_(2.5):16.1,18.1,and 15.1μg/m^(3) and for O_(3):35.0,26.6,and 33.6μg/m^(3).The results indicated spatial and temporal variations between the stations and the pollutants evaluated.The highest PM concentrations were observed in the southern part of the city,while for ozone,higher concentrations were observed in the north.These variations are mainly associated with the influence of local sources in the environment of each site evaluated as well as the meteorological conditions and transport patterns of the study area.This study also verified the existence of differences in the concentrations of the studied pollutants between the dry and rainy seasons and the contribution of local sources as biomass burnings from the Isla Salamanca Natural Park and long-range transport of dust particles from the Sahara Desert.This study provides a scientific baseline for understanding air quality in the city,which enables policy makers to adopt efficient measures that jointly prevent and control pollution.展开更多
The global outbreak of coronavirus infectious disease-2019(COVID-19)draws attentions in the transport and spread of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)in aerosols,wastewater,surface water and s...The global outbreak of coronavirus infectious disease-2019(COVID-19)draws attentions in the transport and spread of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)in aerosols,wastewater,surface water and solid wastes.As pathogens eventually enter the subsurface system,e.g.,soils in the vadose zone and groundwater in the aquifers,they might survive for a prolonged period of time owing to the uniqueness of subsurface environment.In addition,pathogens can transport in groundwater and contaminate surrounding drinking water sources,possessing long-term and concealed risks to human society.This work critically reviews the influential factors of pathogen migration,unravelling the impacts of pathogenic characteristics,vadose zone physiochemical properties and hydrological variables on the migration of typical pathogens in subsurface system.An assessment algorithm and two rating/weighting schemes are proposed to evaluate the migration abilities and risks of pathogens in subsurface environment.As there is still no evidence about the presence and distribution of SARS-CoV-2 in the vadose zones and aquifers,this study also discusses the migration potential and behavior of SARS-CoV-2 viruses in subsurface environment,offering prospective clues and suggestions for its potential risks in drinking water and effective prevention and control from hydrogeological points of view.展开更多
The deterioration of environmental conditions is the major contributory factor to poor health and quality of life that hinders sustainable development in any region.Coal mining is one of the major industries that cont...The deterioration of environmental conditions is the major contributory factor to poor health and quality of life that hinders sustainable development in any region.Coal mining is one of the major industries that contribute to the economy of a country but it also impacts the environment.The chemical parameters of the coal,overburden,soil and sediments along with the coal mine drainage(CMD)were investigated in order to understand the overall environmental impact from high sulphur coal mining at northeastern coalfield(India).It was found that the total sulphur content of the coal is noticeably high compared to the overburden(OB)and soil.The volatile matter of the coal is sufficiently high against the high ash content of the soil and overburden.The water samples have a High Electrical Conductivity(EC)and high Total Dissolve Solid(TDS).Lower values of pH,indicate the dissolution of minerals present in the coal as well as other minerals in the mine rejects/overburden.The chemical and nano-mineralogical composition of coal,soil and overburden samples was studied using a High Resolution-Transmission Electron Microscopy(HR-TEM),Energy Dispersive Spectroscopy(EDS),Selected-Area Diffraction(SAED),Field Emission-Scanning Electron Microscopy(FE-SEM)/EDS,X-ray diffraction(XRD),Fourier Transform Infrared Spectroscopy(FTIR),Raman and Ion-Chromatographic analysis,and Mossbauer spectroscopy.From different geochemical analysis it has been found that the mine water sample from Ledo colliery has the lowest pH value of 3.30,Tirap colliery samples have the highest electrical conductivity value of5.40 ms cm^(-1)Both Ledo and Tirap coals have total sulphur contents within the range 3-3.50%.The coal mine water from Tirap colliery(TW-15 B)has high values of Mg^(2+)(450 ppm),and Br^-(227.17 ppm).XRD analysis revealed the presence of minerals including quartz and hematite in the coals.Mineral analysis of coal mine overburden(OB)indicates the presence both of pyrite and marcasite which was also confirmed in XRD and Mossbauer spectral analysis.The presented data of the minerals and ultra/nano-particles present shows their ability to control the mobility of hazardous elements,suggesting possible use in environmental management technology,including restoration of the delicate Indian coal mine areas.展开更多
Because incomplete confirmation is available concerning the influential role of atmosphere contamination on conjunctivitis,myopia,asthma,and allergic rhinitis in Brazil,the focus of the present work is to explore the ...Because incomplete confirmation is available concerning the influential role of atmosphere contamination on conjunctivitis,myopia,asthma,and allergic rhinitis in Brazil,the focus of the present work is to explore the possible relations among atmosphere contamination and eye problems.Rather that a case study on eye diseases,by way of questionnaires supplemented by the investigation of nanoparticles(NPs)on eyeglasses,the study examines the mechanisms in which NPs and ultra-fine particles are deposited on the glasses of children up to 10 years of age in urban and rural area.The important connection between atmosphere contaminants and individual protection equipment justifies improving indoor school properties in order could protect children’s eyes,particularly in high-pollution/high-particulate areas.展开更多
Real-time disease prediction has emerged as the main focus of study in the field of computerized medicine.Intelligent disease identification framework can assist medical practitioners in diagnosing disease in a way th...Real-time disease prediction has emerged as the main focus of study in the field of computerized medicine.Intelligent disease identification framework can assist medical practitioners in diagnosing disease in a way that is reliable,consistent,and timely,successfully lowering mortality rates,particularly during endemics and pandemics.To prevent this pandemic’s rapid and widespread,it is vital to quickly identify,confine,and treat affected individuals.The need for auxiliary computer-aided diagnostic(CAD)systems has grown.Numerous recent studies have indicated that radiological pictures contained critical information regarding the COVID-19 virus.Utilizing advanced convolutional neural network(CNN)architectures in conjunction with radiological imaging makes it possible to provide rapid,accurate,and extremely useful susceptible classifications.This research work proposes a methodology for real-time detection of COVID-19 infections caused by the Corona Virus.The purpose of this study is to offer a two-way COVID-19(2WCD)diagnosis prediction deep learning system that is built on Transfer Learning Methodologies(TLM)and features customized fine-tuning on top of fully connected layered pre-trained CNN architectures.2WCD has applied modifications to pre-trained models for better performance.It is designed and implemented to improve the generalization ability of the classifier for binary and multi-class models.Along with the ability to differentiate COVID-19 and No-Patient in the binary class model and COVID-19,No-Patient,and Pneumonia in the multi-class model,our framework is augmented with a critical add-on for visually demonstrating infection in any tested radiological image by highlighting the affected region in the patient’s lung in a recognizable color pattern.The proposed system is shown to be extremely robust and reliable for real-time COVID-19 diagnostic prediction.It can also be used to forecast other lung-related disorders.As the system can assist medical practitioners in diagnosing the greatest number of patients in the shortestamount of time, radiologists can also be used or published online to assistany less-experienced individual in obtaining an accurate immediate screeningfor their radiological images.展开更多
Air pollution has become an important issue,especially in Caribbean urban areas,and,particulate matter(PM)emitted by different natural and anthropogenic sources causes environmental and health issues.In this work,we s...Air pollution has become an important issue,especially in Caribbean urban areas,and,particulate matter(PM)emitted by different natural and anthropogenic sources causes environmental and health issues.In this work,we studied the concentrations of PM_(10) and PM_(2.5) sources in an industrial and port urban area in the Caribbean region of Colombia.PM samples were collected within 48-h periods between April and October 2018 by using a Partisol 2000 i-D sampler.Elemental geochemical characterization was performed by X-ray fluorescence(XRF)analysis.Further,ionic species and black carbon(BC)were quantified by ion chromatography and reflectance spectroscopy,respectively.Using the Positive Matrix Factorization(PMF)receptor model,the contributions of PM sources were quantified.The average concentration of PM_(10) was 46.6±16.2μg/m^(3),with high concentrations of Cl and Ca.For PM_(2.5),the average concentration was 12.0±3.2μg/m^(3),and the most abundant components were BC,S,and Cl.The receptor model identified five sources for PM_(10) and PM_(2.5).For both fractions,the contributions of marine sea spray,re-suspended soil,and vehicular traffic were observed.In addition,PM_(2.5) included two mixed sources were found to be fuel oil combustion with fertilizer industry emissions,and secondary aerosol sources with building construction emissions.Further,PM_(10) was found to also include building construction emissions with re-suspended soil,and metallurgical industry emissions.These obtained geochemical atmospheric results are important for the implementation of strategies for the continuous improvement of the air quality of the Caribbean region.展开更多
To provide faster access to the treatment of patients,healthcare system can be integrated with Internet of Things to provide prior and timely health services to the patient.There is a huge limitation in the sensing la...To provide faster access to the treatment of patients,healthcare system can be integrated with Internet of Things to provide prior and timely health services to the patient.There is a huge limitation in the sensing layer as the IoT devices here have low computational power,limited storage and less battery life.So,this huge amount of data needs to be stored on the cloud.The information and the data sensed by these devices is made accessible on the internet from where medical staff,doctors,relatives and family members can access this information.This helps in improving the treatment as well as getting faster medical assistance,tracking of routine activities and health focus of elderly people on frequent basis.However,the data transmission from IoT devices to the cloud faces many security challenges and is vulnerable to different security and privacy threats during the transmission path.The purpose of this research is to design a Certificateless Secured Signature Scheme that will provide a magnificent amount of security during the transmission of data.Certificateless signature,that removes the intricate certificate management and key escrow problem,is one of the practical methods to provide data integrity and identity authentication for the IoT.Experimental result shows that the proposed scheme performs better than the existing certificateless signature schemes in terms of computational cost,encryption and decryption time.This scheme is the best combination of high security and cost efficiency and is further suitable for the resource constrained IoT environment.展开更多
The rapid expansion of Internet of Things(IoT)devices deploys various sensors in different applications like homes,cities and offices.IoT applications depend upon the accuracy of sensor data.So,it is necessary to pred...The rapid expansion of Internet of Things(IoT)devices deploys various sensors in different applications like homes,cities and offices.IoT applications depend upon the accuracy of sensor data.So,it is necessary to predict faults in the sensor and isolate their cause.A novel primitive technique named fall curve is presented in this paper which characterizes sensor faults.This technique identifies the faulty sensor and determines the correct working of the sensor.Different sources of sensor faults are explained in detail whereas various faults that occurred in sensor nodes available in IoT devices are also presented in tabular form.Fault prediction in digital and analog sensors along with methods of sensor fault prediction are described.There are several advantages and disadvantages of sensor fault prediction methods and the fall curve technique.So,some solutions are provided to overcome the limitations of the fall curve technique.In this paper,a bibliometric analysis is carried out to visually analyze 63 papers fetched from the Scopus database for the past five years.Its novelty is to predict a fault before its occurrence by looking at the fall curve.The sensing of current flow in devices is important to prevent a major loss.So,the fall curves of ACS712 current sensors configured on different devices are drawn for predicting faulty or non-faulty devices.The analysis result proved that if any of the current sensors gets faulty,then the fall curve will differ and the value will immediately drop to zero.Various evaluation metrics for fault prediction are also described in this paper.At last,this paper also addresses some possible open research issues which are important to deal with false IoT sensor data.展开更多
Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo（NE Tenerife）. Seven campaigns were conducted from November 2007 to June 2010 and te...Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo（NE Tenerife）. Seven campaigns were conducted from November 2007 to June 2010 and temporal variations were found, as well as differences among sampling stations. The polychaete H. carunculata obtained its highest abundance in sediments beneath fish cages throughout the study period. Thus, the assemblages of this omnivorous species were favoured by the presence of fish cages.展开更多
Corona Virus Disease 2019(COVID-19)caused by the novel coronavirus,results in an acute respiratory condition coronavirus 2(SARS-CoV-2)and is highly infectious.The recent spread of this virus has caused a global pandem...Corona Virus Disease 2019(COVID-19)caused by the novel coronavirus,results in an acute respiratory condition coronavirus 2(SARS-CoV-2)and is highly infectious.The recent spread of this virus has caused a global pandemic.Currently,the transmission routes of SARS-CoV-2 are being established,especially the role of environmental transmission.Here we review the environmental transmission routes and persistence of SARS-CoV-2.Recent studies have established that the transmission of this virus may occur,amongst others,in the air,water,soil,cold-chain,biota,and surface contact.It has also been found that the survival potential of the SARS-CoV-2 virus is dependent on different environmental conditions and pollution.Potentially important pathways include aerosol and fecal matter.Particulate matter may also be a carrier for SARS-CoV-2.Since microscopic particles can be easily absorbed by humans,more attention must be focused on the dissemination of these particles.These considerations are required to evolve a theoretical platform for epidemic control and to minimize the global threat from future epidemics.展开更多
This study contributes with the first data on physical and taxonomical structure of macrofaunal assemblages of maerl beds from the Canary Islands. Maerl beds and Cymodocea nodosa meadows of the Canary Islands are cons...This study contributes with the first data on physical and taxonomical structure of macrofaunal assemblages of maerl beds from the Canary Islands. Maerl beds and Cymodocea nodosa meadows of the Canary Islands are considered biodiversity hot-spots in terms of taxonomic and functional biodiversity with a broad geographical and depth ranges. The authors have studied the structure of the macrofaunal assemblages on different habitat types （Cymodocea, Caulerpa, sabellid field, garden eel and maerl beds）. Samples were taken at a range of depths between 14 and 46 m. Correlations were performed among abiotic variables （granulometry, organic matter, nitrogen and phosphates） and the most abundant taxa. Similarity analysis was performed to explore the patchiness of seabeds at a local scale. Significant differences were found in macrofaunal assemblages among seabed types, with highest abundances and lowest biodiversity in sabellid fields, where the sabellid Bispira viola dominated. The polychaetes Aponuphis bilineata and Chone filicauda and the mollusc Turritella brochii were the most abundant taxa on maerl beds. The mosaic of granulometric conditions would explain the associated macroinfaunal community structure and contribute to the creation of diversity on these relatively well preserved seabeds at a local scale.展开更多
Throughout the shores of the world, a confluence of different sources of pollution is common, e.g., through outlets releasing brine, industrial, and domestic sewage. In this study, we assessed whether a combined dispo...Throughout the shores of the world, a confluence of different sources of pollution is common, e.g., through outlets releasing brine, industrial, and domestic sewage. In this study, we assessed whether a combined disposal of domestic sewage and brine altered the patterns of abundance and assemblage structure of sub- tidal macrofauna inhabiting sandy seabeds on the south coast of Gran Canaria （Canary Islands, NE Atlantic Ocean）. Samples were collected in two surveys （May 2008 and January 2009） at three distances （0, 15, and 30 m） away from the discharge point. Macrofaunal abundances showed different patterns with varying proximity from the disposal point in the two surveys. In May 2008, lower abundances were observed at 0 m （53.89±46.82 ind.） than at 15 m （120±91.7 ind.） and 30 m （283.89±189.33 ind.） away from the dis- posal point. In January 2009, however, higher abundances were observed at 0 m （131.33±58.69 ind.） than at 30 m （100±24.44 ind.） and 15 m （84.78±58.39 ind.） away from the disposal point. Significant differ- ences in macrofaunal assemblage structure were found with varying proximity from the discharge point in both surveys. The effect of proximity from the disposal point was confounded by changes in sedimen- tary composition between surveys, which contributed to explain differences in macrofaunal abundances and assemblage structure with varying proximity from the discharge point. As a result, confounding driver- s of macrofaunal assemblage structure, here, changes in sediment composition, accounted for changes in macrofaunal abundances and assemblage structure with varying proximity from a combined disposal point of brine and sewage.展开更多
A shallow subtidal （3 m deep） meiofaunal assemblage in Los Abrigos Bay, Tenerife, Canary Islands was sam- pled during May 2000-April 2001. The main aims were to （1） find temporal variations in meiofaunal assem- bl...A shallow subtidal （3 m deep） meiofaunal assemblage in Los Abrigos Bay, Tenerife, Canary Islands was sam- pled during May 2000-April 2001. The main aims were to （1） find temporal variations in meiofaunal assem- blage structure and overall abundance, as well as in the most abundant meiofaunal species throughout the study period, and （2） identify environmental variables （sedimentary composition, organic matter content, and total nitrogen） that better explain meiofaunal assemblage structure during the study year. The most abundant species were the nematodes Siphonolaimus sp. 2 and Catanema sp., which represented 46.2% of the overall meiofaunal abundances and varied significantly throughout the study duration. Overall meio- faunal abundance and the most abundant taxonomic groups （nematodes, copepods, and oligochaetes） showed significant temporal variations during the study period. Nematodes overwhelmingly dominated during the study period, ranging from 78% in May to 97.34% in February. Multivariate analyses showed seasonality in meiofaunal community structure during the study year, with the lowest abundances in May. Keywords： Meiofauna, assemblage structure, subtidal, Canary Islands, Atlantic Ocean展开更多
The ceramics industry,resulting from developments of modern compounds,is a segment of great influence in worldwide sustainability.Artisanal ceramic factories based on wood combustion have significant risks for the cre...The ceramics industry,resulting from developments of modern compounds,is a segment of great influence in worldwide sustainability.Artisanal ceramic factories based on wood combustion have significant risks for the creation and discharge of atmosphere nanoparticles(NPs)and ultra-fine particles(UFPs).At present,there is insufficient recognition on the influence of engineered-NPs on the atmosphere and health.Real improvements are indispensable to diminish contact with NPs.The present study demonstrates the main NPs and UFPS present in an area of intense artisanal wood-combustion ceramic manufacturing.Particulate matter was sampled for morphological,chemical,and geochemical studies by sophisticated electron microbeam microscopy,X-Ray Diffraction,and Raman spectroscopy.From NPs configuration(<10 nm)we identify nucleation.Several amorphous NPs(>10 nm)were produced around the studied artisanal ceramic factories.This study presents an indication of the recent information on population and work-related contact to NPs in the artisanal ceramic factories and their influence on health.展开更多
Assessing the physical,geographic,chemical,and geological aspects are important to understand environmental impacts as well as health concerns in view of building a more sustainable planet with circular economies that...Assessing the physical,geographic,chemical,and geological aspects are important to understand environmental impacts as well as health concerns in view of building a more sustainable planet with circular economies that would last for the foreseeable future.In the recent years,the significance of incorporating ecosystem,anthropogenic activities,and climate has fortified from being an academic concern(e.g.,WEF,2011)into a broadly societal concern as the forecasted realities of environmental deterioration and global climate change come to pass.展开更多
BACKGROUND Urticaria is one of the most common causes of emergency room visits.It is defined as an acute inflammatory dermatosis,characterized by localized degranulation of mast cells,with consequent dermal microvascu...BACKGROUND Urticaria is one of the most common causes of emergency room visits.It is defined as an acute inflammatory dermatosis,characterized by localized degranulation of mast cells,with consequent dermal microvascular and formation of edematous and pruritic plaques called hives.Urticaria affects the skin and tissues of the superficial mucosa.Sometimes it is accompanied by angioedema,which is characterized by deeper edema of the dermis and subcutaneous cellular tissue known as the urticarial-angioedema syndrome.About 15%-25%of the general population has suffered at least one type of urticaria at some point during their lifetime and hyperpermeability estimated at 7.6%-16%and has experienced acute urticaria that is usually self-limited and spontaneously resolves without requiring medical attention.CASE SUMMARY We present the case of a young male patient who was referred to our department with a clinical picture of 4 mo of pruritus associated with hives of variable sizes,irregular borders,with interlesional confluence,that were non-painful,without involvement of the palms and soles of the feet but with a tendency to progression in a generalized manner.He had multiple emergency room visits and poor response to antihistamines and systemic corticosteroids.Imaging studies demonstrated nodules in the lower lingula segment,at the level of the greater fissure and in the anterior contour of the left anterior basal segment associated with parahiliar adenopathies in the absence of findings suggestive of infectious or autoimmune etiology.Segmental lobectomy was performed by thoracoscopy with resection of a lung nodule in the lingula and biopsy of the para-aortic mediastinal ganglion.The histopathological report showed the presence of poorly differentiated invasive adenocarcinoma with a solid morphological and acinar pattern with immunohistochemical description of lung tissue that expresses strong positive and diffuse reaction for thyroid transcription factor 1(TTF-1)with negativity to P40 for a histopathological diagnosis of malignant epithelial neoplasia with expression of infiltrating adenocarcinoma.Spontaneous chronic urticaria is considered possibly secondary to lung adenocarcinoma.CONCLUSION Chronic spontaneous urticaria is considered a paraneoplastic dermatosis with a controversial association in the literature.In the presented case,a young patient presented with chronic refractory urticaria and after an exhaustive clinical work-up was found to have a diagnosis of poorly differentiated lung adenocarcinoma with high expression of TTF-1.According to the Curth criteria,the urticaria presented by the patient is related to the oncological diagnosis.In addition,the high expression of TTF-1 documented in this case could be acting as an autoantigen that would cause chronic spontaneous urticaria.Further research evaluating a causal relationship between the TFF-1 protein and urticaria in lung cancer is needed.展开更多
文摘Urban agenda nowadays puts pedestrians as the axis of urban design, and pedestrians are the most important thing in the city. The architect takes that idea and applies it in the project, and he focuses on prioritizing the pedestrian over the cars. Public spaces filled with green zones are a main element, water treatment is a design determinant, buildings use natural illumination as much as possible and culture and arts are reinforced through new scenarios.
基金Project supported by the Brazilian National Council for Scientific and Technological Development/CNPq(405982/2022-4 and 303992/2021-2)。
文摘Ouricuri endocarp was utilized as a biosorbent for the recovery of europium(Eu(Ⅲ))from aqueous solutions and rare earth elements(REEs)from authentic leachate derived from phosphogypsum,which encompasses various REEs.Various characterization techniques were applied to analyze the physicochemical and adsorptive properties of the biosorbent.The results indicate that the adsorption kinetic data conform well to the pseudo-first-order model,while the Liu model describes the equilibrium data well.Ouricuri endocarp and Eu interactions are favorable and spontaneous.The maximum adsorption capacity for Eu(Ⅲ)is determined to be 22.9 mg/g according to the Liu model.Based on experimental results and adsorbent characteristics,the proposed adsorption mechanisms between ouricuri endocarp and Eu include ion exchange and electrostatic interactions as the primary mechanisms.The Eu(Ⅲ)recovery is also feasible as a continuous flow process demonstrating inclined breakthrough curves and lower values of the length of the mass transfer zone.Ouricuri endocarp demonstrates its selectivity for recovering various REEs from authentic phosphogypsum leachate.It achieves a 98%recovery rate for Eu and approximately 60%for Ce,La,and Nd,affirming its efficacy under real-world conditions.Finally,concentration of REE was done by ashing loaded ouricuri endocarp,and a solid with around 34%(in weight)of REE is obtained.
文摘Deterioration of air quality due to the increase in atmospheric emissions from biomass burning(BB)is one of the major environmental problems worldwide.In this study,we estimated the contributions of BB to PM_(2.5) concentrations in the municipalities of Soledad and Malambo located in the Colombian Caribbean.The evaluation period ranged from February 24 to March 30,2018,a period with a high number of BB events recorded in the surroundings of the evaluated sites.The contribution of BB to the two sampling sites was estimated using the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)dispersion model with forwarding trajectories from each of the burning points identified by satellite images(n=1089).The PM_(2.5) emissions were determined using the fire radiative power(FRP),obtained by remote-sensing data,and corresponded to the radiant energy released per time unit by burning vegetation.The average PM_(2.5) concentrations during the evaluation period were 19.91μg/m^(3) for Soledad and 22.44μg/m^(3) for Malambo.The average contribution of BB to these municipalities was 22.8%and 28.8%,respectively.The methodology used in this study allowed to estimate the contribution of this important source without knowledge of a previous tracer of BB,thereby increasing the use of the proposed procedure worldwide.This information would enable the implementation of effective mitigation,thereby diminishing the adverse impact of PM_(2.5) on the health of the population.
基金financial support from ColcienciasColombia(Project 141180764164,Contract 815-2018)。
文摘Air pollution by particulate matter(PM)is one of the main threats to human health,particularly in large cities where pollution levels are continually exceeded.According to their source of emission,geography,and local meteorology,the pollutant particles vary in size and composition.These particles are conditioned to the aerodynamic diameter and thus classified as coarse(2.5–10μm),fine(0.1–2.5μm),and ultrafine(<0.1μm),where the degree of toxicity becomes greater for smaller particles.These particles can get into the lungs and translocate into vital organs due to their size,causing significant human health consequences.Besides,PM pollutants have been linked to respiratory conditions,genotoxic,mutagenic,and carcinogenic activity in human beings.This paper presents an overview of emission sources,physicochemical characteristics,collection and measurement methodologies,toxicity,and existing control mechanisms for ultrafine particles(UFPs)in the last fifteen years.
文摘Air pollution has become a critical issue in urban areas,so a broad understanding of its spatiotemporal characteristics is important to develop public policies.This study analyzes the spatiotemporal variation of atmospheric particulate matter(PM_(10) and PM_(2.5))and ozone(O_(3))in Barranquilla,Colombia from March 2018 to June 2019 in three monitoring stations.The average concentrations observed for the Móvil,Policía,and Tres Avemarías stations,respectively,for PM_(10):46.4,51.4,and 39.7μg/m^(3);for PM_(2.5):16.1,18.1,and 15.1μg/m^(3) and for O_(3):35.0,26.6,and 33.6μg/m^(3).The results indicated spatial and temporal variations between the stations and the pollutants evaluated.The highest PM concentrations were observed in the southern part of the city,while for ozone,higher concentrations were observed in the north.These variations are mainly associated with the influence of local sources in the environment of each site evaluated as well as the meteorological conditions and transport patterns of the study area.This study also verified the existence of differences in the concentrations of the studied pollutants between the dry and rainy seasons and the contribution of local sources as biomass burnings from the Isla Salamanca Natural Park and long-range transport of dust particles from the Sahara Desert.This study provides a scientific baseline for understanding air quality in the city,which enables policy makers to adopt efficient measures that jointly prevent and control pollution.
基金financially supported by the National Science Foundation of China(Grant No.52091543)the support of Chinese Government’s Thousand Talents Plan for Young Professionals。
文摘The global outbreak of coronavirus infectious disease-2019(COVID-19)draws attentions in the transport and spread of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)in aerosols,wastewater,surface water and solid wastes.As pathogens eventually enter the subsurface system,e.g.,soils in the vadose zone and groundwater in the aquifers,they might survive for a prolonged period of time owing to the uniqueness of subsurface environment.In addition,pathogens can transport in groundwater and contaminate surrounding drinking water sources,possessing long-term and concealed risks to human society.This work critically reviews the influential factors of pathogen migration,unravelling the impacts of pathogenic characteristics,vadose zone physiochemical properties and hydrological variables on the migration of typical pathogens in subsurface system.An assessment algorithm and two rating/weighting schemes are proposed to evaluate the migration abilities and risks of pathogens in subsurface environment.As there is still no evidence about the presence and distribution of SARS-CoV-2 in the vadose zones and aquifers,this study also discusses the migration potential and behavior of SARS-CoV-2 viruses in subsurface environment,offering prospective clues and suggestions for its potential risks in drinking water and effective prevention and control from hydrogeological points of view.
基金The financial assistance from CSIR,New Delhi(MLP6000-WP-Ⅲ)
文摘The deterioration of environmental conditions is the major contributory factor to poor health and quality of life that hinders sustainable development in any region.Coal mining is one of the major industries that contribute to the economy of a country but it also impacts the environment.The chemical parameters of the coal,overburden,soil and sediments along with the coal mine drainage(CMD)were investigated in order to understand the overall environmental impact from high sulphur coal mining at northeastern coalfield(India).It was found that the total sulphur content of the coal is noticeably high compared to the overburden(OB)and soil.The volatile matter of the coal is sufficiently high against the high ash content of the soil and overburden.The water samples have a High Electrical Conductivity(EC)and high Total Dissolve Solid(TDS).Lower values of pH,indicate the dissolution of minerals present in the coal as well as other minerals in the mine rejects/overburden.The chemical and nano-mineralogical composition of coal,soil and overburden samples was studied using a High Resolution-Transmission Electron Microscopy(HR-TEM),Energy Dispersive Spectroscopy(EDS),Selected-Area Diffraction(SAED),Field Emission-Scanning Electron Microscopy(FE-SEM)/EDS,X-ray diffraction(XRD),Fourier Transform Infrared Spectroscopy(FTIR),Raman and Ion-Chromatographic analysis,and Mossbauer spectroscopy.From different geochemical analysis it has been found that the mine water sample from Ledo colliery has the lowest pH value of 3.30,Tirap colliery samples have the highest electrical conductivity value of5.40 ms cm^(-1)Both Ledo and Tirap coals have total sulphur contents within the range 3-3.50%.The coal mine water from Tirap colliery(TW-15 B)has high values of Mg^(2+)(450 ppm),and Br^-(227.17 ppm).XRD analysis revealed the presence of minerals including quartz and hematite in the coals.Mineral analysis of coal mine overburden(OB)indicates the presence both of pyrite and marcasite which was also confirmed in XRD and Mossbauer spectral analysis.The presented data of the minerals and ultra/nano-particles present shows their ability to control the mobility of hazardous elements,suggesting possible use in environmental management technology,including restoration of the delicate Indian coal mine areas.
基金the Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)for financial support。
文摘Because incomplete confirmation is available concerning the influential role of atmosphere contamination on conjunctivitis,myopia,asthma,and allergic rhinitis in Brazil,the focus of the present work is to explore the possible relations among atmosphere contamination and eye problems.Rather that a case study on eye diseases,by way of questionnaires supplemented by the investigation of nanoparticles(NPs)on eyeglasses,the study examines the mechanisms in which NPs and ultra-fine particles are deposited on the glasses of children up to 10 years of age in urban and rural area.The important connection between atmosphere contaminants and individual protection equipment justifies improving indoor school properties in order could protect children’s eyes,particularly in high-pollution/high-particulate areas.
基金This work was funded by the Researchers Supporting Project Number(RSP-2021/300),King Saud University,Riyadh,Saudi Arabia.
文摘Real-time disease prediction has emerged as the main focus of study in the field of computerized medicine.Intelligent disease identification framework can assist medical practitioners in diagnosing disease in a way that is reliable,consistent,and timely,successfully lowering mortality rates,particularly during endemics and pandemics.To prevent this pandemic’s rapid and widespread,it is vital to quickly identify,confine,and treat affected individuals.The need for auxiliary computer-aided diagnostic(CAD)systems has grown.Numerous recent studies have indicated that radiological pictures contained critical information regarding the COVID-19 virus.Utilizing advanced convolutional neural network(CNN)architectures in conjunction with radiological imaging makes it possible to provide rapid,accurate,and extremely useful susceptible classifications.This research work proposes a methodology for real-time detection of COVID-19 infections caused by the Corona Virus.The purpose of this study is to offer a two-way COVID-19(2WCD)diagnosis prediction deep learning system that is built on Transfer Learning Methodologies(TLM)and features customized fine-tuning on top of fully connected layered pre-trained CNN architectures.2WCD has applied modifications to pre-trained models for better performance.It is designed and implemented to improve the generalization ability of the classifier for binary and multi-class models.Along with the ability to differentiate COVID-19 and No-Patient in the binary class model and COVID-19,No-Patient,and Pneumonia in the multi-class model,our framework is augmented with a critical add-on for visually demonstrating infection in any tested radiological image by highlighting the affected region in the patient’s lung in a recognizable color pattern.The proposed system is shown to be extremely robust and reliable for real-time COVID-19 diagnostic prediction.It can also be used to forecast other lung-related disorders.As the system can assist medical practitioners in diagnosing the greatest number of patients in the shortestamount of time, radiologists can also be used or published online to assistany less-experienced individual in obtaining an accurate immediate screeningfor their radiological images.
基金financial support from the Departamento Administrativo de CienciaTecnología e Innovación(Colciencias)for Project#141180764164,Contract 815-2018。
文摘Air pollution has become an important issue,especially in Caribbean urban areas,and,particulate matter(PM)emitted by different natural and anthropogenic sources causes environmental and health issues.In this work,we studied the concentrations of PM_(10) and PM_(2.5) sources in an industrial and port urban area in the Caribbean region of Colombia.PM samples were collected within 48-h periods between April and October 2018 by using a Partisol 2000 i-D sampler.Elemental geochemical characterization was performed by X-ray fluorescence(XRF)analysis.Further,ionic species and black carbon(BC)were quantified by ion chromatography and reflectance spectroscopy,respectively.Using the Positive Matrix Factorization(PMF)receptor model,the contributions of PM sources were quantified.The average concentration of PM_(10) was 46.6±16.2μg/m^(3),with high concentrations of Cl and Ca.For PM_(2.5),the average concentration was 12.0±3.2μg/m^(3),and the most abundant components were BC,S,and Cl.The receptor model identified five sources for PM_(10) and PM_(2.5).For both fractions,the contributions of marine sea spray,re-suspended soil,and vehicular traffic were observed.In addition,PM_(2.5) included two mixed sources were found to be fuel oil combustion with fertilizer industry emissions,and secondary aerosol sources with building construction emissions.Further,PM_(10) was found to also include building construction emissions with re-suspended soil,and metallurgical industry emissions.These obtained geochemical atmospheric results are important for the implementation of strategies for the continuous improvement of the air quality of the Caribbean region.
基金This project was funded by the Deanship of Scientific Research(DSR)King Abdulaziz University,Jeddah,under Grant No.(D14-611-1443)The authors,therefore,gratefully acknowledge DSR technical and financial support。
文摘To provide faster access to the treatment of patients,healthcare system can be integrated with Internet of Things to provide prior and timely health services to the patient.There is a huge limitation in the sensing layer as the IoT devices here have low computational power,limited storage and less battery life.So,this huge amount of data needs to be stored on the cloud.The information and the data sensed by these devices is made accessible on the internet from where medical staff,doctors,relatives and family members can access this information.This helps in improving the treatment as well as getting faster medical assistance,tracking of routine activities and health focus of elderly people on frequent basis.However,the data transmission from IoT devices to the cloud faces many security challenges and is vulnerable to different security and privacy threats during the transmission path.The purpose of this research is to design a Certificateless Secured Signature Scheme that will provide a magnificent amount of security during the transmission of data.Certificateless signature,that removes the intricate certificate management and key escrow problem,is one of the practical methods to provide data integrity and identity authentication for the IoT.Experimental result shows that the proposed scheme performs better than the existing certificateless signature schemes in terms of computational cost,encryption and decryption time.This scheme is the best combination of high security and cost efficiency and is further suitable for the resource constrained IoT environment.
基金supported by Taif University Researchers supporting Project number(TURSP-2020/347),Taif University,Taif,Saudi Arabia.
文摘The rapid expansion of Internet of Things(IoT)devices deploys various sensors in different applications like homes,cities and offices.IoT applications depend upon the accuracy of sensor data.So,it is necessary to predict faults in the sensor and isolate their cause.A novel primitive technique named fall curve is presented in this paper which characterizes sensor faults.This technique identifies the faulty sensor and determines the correct working of the sensor.Different sources of sensor faults are explained in detail whereas various faults that occurred in sensor nodes available in IoT devices are also presented in tabular form.Fault prediction in digital and analog sensors along with methods of sensor fault prediction are described.There are several advantages and disadvantages of sensor fault prediction methods and the fall curve technique.So,some solutions are provided to overcome the limitations of the fall curve technique.In this paper,a bibliometric analysis is carried out to visually analyze 63 papers fetched from the Scopus database for the past five years.Its novelty is to predict a fault before its occurrence by looking at the fall curve.The sensing of current flow in devices is important to prevent a major loss.So,the fall curves of ACS712 current sensors configured on different devices are drawn for predicting faulty or non-faulty devices.The analysis result proved that if any of the current sensors gets faulty,then the fall curve will differ and the value will immediately drop to zero.Various evaluation metrics for fault prediction are also described in this paper.At last,this paper also addresses some possible open research issues which are important to deal with false IoT sensor data.
基金To the company Cultivos Marinos del Atlántico SL for logistic facilities and financial support throughout the present study
文摘Abundances of the fireworm Hermodice carunculata were counted through a monitoring assessment study of fish cages in Barranco Hondo（NE Tenerife）. Seven campaigns were conducted from November 2007 to June 2010 and temporal variations were found, as well as differences among sampling stations. The polychaete H. carunculata obtained its highest abundance in sediments beneath fish cages throughout the study period. Thus, the assemblages of this omnivorous species were favoured by the presence of fish cages.
基金supported by the National Natural Science Foundation of China(NSFC)(Grant No.42075107)the Projects of International Cooperation and Exchanges NSFC(Grant No.41571130031)the Yueqi Scholar fund of China University of Mining and Technology(Beijing).
文摘Corona Virus Disease 2019(COVID-19)caused by the novel coronavirus,results in an acute respiratory condition coronavirus 2(SARS-CoV-2)and is highly infectious.The recent spread of this virus has caused a global pandemic.Currently,the transmission routes of SARS-CoV-2 are being established,especially the role of environmental transmission.Here we review the environmental transmission routes and persistence of SARS-CoV-2.Recent studies have established that the transmission of this virus may occur,amongst others,in the air,water,soil,cold-chain,biota,and surface contact.It has also been found that the survival potential of the SARS-CoV-2 virus is dependent on different environmental conditions and pollution.Potentially important pathways include aerosol and fecal matter.Particulate matter may also be a carrier for SARS-CoV-2.Since microscopic particles can be easily absorbed by humans,more attention must be focused on the dissemination of these particles.These considerations are required to evolve a theoretical platform for epidemic control and to minimize the global threat from future epidemics.
文摘This study contributes with the first data on physical and taxonomical structure of macrofaunal assemblages of maerl beds from the Canary Islands. Maerl beds and Cymodocea nodosa meadows of the Canary Islands are considered biodiversity hot-spots in terms of taxonomic and functional biodiversity with a broad geographical and depth ranges. The authors have studied the structure of the macrofaunal assemblages on different habitat types （Cymodocea, Caulerpa, sabellid field, garden eel and maerl beds）. Samples were taken at a range of depths between 14 and 46 m. Correlations were performed among abiotic variables （granulometry, organic matter, nitrogen and phosphates） and the most abundant taxa. Similarity analysis was performed to explore the patchiness of seabeds at a local scale. Significant differences were found in macrofaunal assemblages among seabed types, with highest abundances and lowest biodiversity in sabellid fields, where the sabellid Bispira viola dominated. The polychaetes Aponuphis bilineata and Chone filicauda and the mollusc Turritella brochii were the most abundant taxa on maerl beds. The mosaic of granulometric conditions would explain the associated macroinfaunal community structure and contribute to the creation of diversity on these relatively well preserved seabeds at a local scale.
基金The Spanish Ministry of the Environment and Rural and Marine Affairs (Project:"Minimisation of environmental impacts from brine disposals over marine seabed biodiversity,with special reference to Cymodocea nodosa seagrass meadows"2007–2010) under contract No.056/SGTB/2007/2.4
文摘Throughout the shores of the world, a confluence of different sources of pollution is common, e.g., through outlets releasing brine, industrial, and domestic sewage. In this study, we assessed whether a combined disposal of domestic sewage and brine altered the patterns of abundance and assemblage structure of sub- tidal macrofauna inhabiting sandy seabeds on the south coast of Gran Canaria （Canary Islands, NE Atlantic Ocean）. Samples were collected in two surveys （May 2008 and January 2009） at three distances （0, 15, and 30 m） away from the discharge point. Macrofaunal abundances showed different patterns with varying proximity from the disposal point in the two surveys. In May 2008, lower abundances were observed at 0 m （53.89±46.82 ind.） than at 15 m （120±91.7 ind.） and 30 m （283.89±189.33 ind.） away from the dis- posal point. In January 2009, however, higher abundances were observed at 0 m （131.33±58.69 ind.） than at 30 m （100±24.44 ind.） and 15 m （84.78±58.39 ind.） away from the disposal point. Significant differ- ences in macrofaunal assemblage structure were found with varying proximity from the discharge point in both surveys. The effect of proximity from the disposal point was confounded by changes in sedimen- tary composition between surveys, which contributed to explain differences in macrofaunal abundances and assemblage structure with varying proximity from the discharge point. As a result, confounding driver- s of macrofaunal assemblage structure, here, changes in sediment composition, accounted for changes in macrofaunal abundances and assemblage structure with varying proximity from a combined disposal point of brine and sewage.
文摘A shallow subtidal （3 m deep） meiofaunal assemblage in Los Abrigos Bay, Tenerife, Canary Islands was sam- pled during May 2000-April 2001. The main aims were to （1） find temporal variations in meiofaunal assem- blage structure and overall abundance, as well as in the most abundant meiofaunal species throughout the study period, and （2） identify environmental variables （sedimentary composition, organic matter content, and total nitrogen） that better explain meiofaunal assemblage structure during the study year. The most abundant species were the nematodes Siphonolaimus sp. 2 and Catanema sp., which represented 46.2% of the overall meiofaunal abundances and varied significantly throughout the study duration. Overall meio- faunal abundance and the most abundant taxonomic groups （nematodes, copepods, and oligochaetes） showed significant temporal variations during the study period. Nematodes overwhelmingly dominated during the study period, ranging from 78% in May to 97.34% in February. Multivariate analyses showed seasonality in meiofaunal community structure during the study year, with the lowest abundances in May. Keywords： Meiofauna, assemblage structure, subtidal, Canary Islands, Atlantic Ocean
文摘The ceramics industry,resulting from developments of modern compounds,is a segment of great influence in worldwide sustainability.Artisanal ceramic factories based on wood combustion have significant risks for the creation and discharge of atmosphere nanoparticles(NPs)and ultra-fine particles(UFPs).At present,there is insufficient recognition on the influence of engineered-NPs on the atmosphere and health.Real improvements are indispensable to diminish contact with NPs.The present study demonstrates the main NPs and UFPS present in an area of intense artisanal wood-combustion ceramic manufacturing.Particulate matter was sampled for morphological,chemical,and geochemical studies by sophisticated electron microbeam microscopy,X-Ray Diffraction,and Raman spectroscopy.From NPs configuration(<10 nm)we identify nucleation.Several amorphous NPs(>10 nm)were produced around the studied artisanal ceramic factories.This study presents an indication of the recent information on population and work-related contact to NPs in the artisanal ceramic factories and their influence on health.
文摘Assessing the physical,geographic,chemical,and geological aspects are important to understand environmental impacts as well as health concerns in view of building a more sustainable planet with circular economies that would last for the foreseeable future.In the recent years,the significance of incorporating ecosystem,anthropogenic activities,and climate has fortified from being an academic concern(e.g.,WEF,2011)into a broadly societal concern as the forecasted realities of environmental deterioration and global climate change come to pass.
文摘BACKGROUND Urticaria is one of the most common causes of emergency room visits.It is defined as an acute inflammatory dermatosis,characterized by localized degranulation of mast cells,with consequent dermal microvascular and formation of edematous and pruritic plaques called hives.Urticaria affects the skin and tissues of the superficial mucosa.Sometimes it is accompanied by angioedema,which is characterized by deeper edema of the dermis and subcutaneous cellular tissue known as the urticarial-angioedema syndrome.About 15%-25%of the general population has suffered at least one type of urticaria at some point during their lifetime and hyperpermeability estimated at 7.6%-16%and has experienced acute urticaria that is usually self-limited and spontaneously resolves without requiring medical attention.CASE SUMMARY We present the case of a young male patient who was referred to our department with a clinical picture of 4 mo of pruritus associated with hives of variable sizes,irregular borders,with interlesional confluence,that were non-painful,without involvement of the palms and soles of the feet but with a tendency to progression in a generalized manner.He had multiple emergency room visits and poor response to antihistamines and systemic corticosteroids.Imaging studies demonstrated nodules in the lower lingula segment,at the level of the greater fissure and in the anterior contour of the left anterior basal segment associated with parahiliar adenopathies in the absence of findings suggestive of infectious or autoimmune etiology.Segmental lobectomy was performed by thoracoscopy with resection of a lung nodule in the lingula and biopsy of the para-aortic mediastinal ganglion.The histopathological report showed the presence of poorly differentiated invasive adenocarcinoma with a solid morphological and acinar pattern with immunohistochemical description of lung tissue that expresses strong positive and diffuse reaction for thyroid transcription factor 1(TTF-1)with negativity to P40 for a histopathological diagnosis of malignant epithelial neoplasia with expression of infiltrating adenocarcinoma.Spontaneous chronic urticaria is considered possibly secondary to lung adenocarcinoma.CONCLUSION Chronic spontaneous urticaria is considered a paraneoplastic dermatosis with a controversial association in the literature.In the presented case,a young patient presented with chronic refractory urticaria and after an exhaustive clinical work-up was found to have a diagnosis of poorly differentiated lung adenocarcinoma with high expression of TTF-1.According to the Curth criteria,the urticaria presented by the patient is related to the oncological diagnosis.In addition,the high expression of TTF-1 documented in this case could be acting as an autoantigen that would cause chronic spontaneous urticaria.Further research evaluating a causal relationship between the TFF-1 protein and urticaria in lung cancer is needed.
