The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and main...The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce steroids.The main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.展开更多
BACKGROUND Pancreatic cystic lesions are common in patients eligible for solid organ transplan-tation.It has been shown that the need for immunosuppression after organ transplantation increases the rate of malignancie...BACKGROUND Pancreatic cystic lesions are common in patients eligible for solid organ transplan-tation.It has been shown that the need for immunosuppression after organ transplantation increases the rate of malignancies in organ recipients.However,the impact of immunosuppression on pancreatic cystic lesions is yet unknown.AIM To evaluate the prevalence of pancreatic cystic lesions and the risk of cyst progression in immunosuppressed patients.METHODS A systematic literature search was performed in relevant databases.Studies reporting either on the prevalence and/or the incidence of pancreatic cyst progression compared to a control group were implemented in the first systematic review and meta-analysis on this topic.RESULTS The prevalence of pancreatic cystic lesions was comparable with 7%(95%CI:5%-11%)in the immunosuppressed cohort and 9%(95%CI:5%-16%)in the control cohort.The mean cyst size increase in the immunosuppression group was 3.2 mm(range 1.0-5.2mm)compared to 3.5 mm(1.0-6.9)in the control group(standar-dized mean difference 0.0 mm,95%CI:-0.3-0.2 mm,P=0.72).There was also no significant increase in the development of resection criteria or worrisome features under immunosuppression either[relative risk 1.1(fixed effect model),1.2(ran-dom effects model),P=0.61].CONCLUSION Immunosuppression does not increase the prevalence of pancreatic cystic lesions,nor does it increase the risk of cyst progression in terms of cyst size and development of resection criteria.Therefore,pancreatic cystic lesions in transplant candidates should not be a contraindication for solid organ transplantation.展开更多
In popular history of science,we find the persistent narrative that traditionally Western Culture over centuries regarded the age of the Earth as brief-but a few thousand years old-and that it was scientific progress ...In popular history of science,we find the persistent narrative that traditionally Western Culture over centuries regarded the age of the Earth as brief-but a few thousand years old-and that it was scientific progress basically during the 19th century that extended this timescale against opposition from religious zealots to encompass millions of years and finally with radiometric dating to some 4.5 billion years.This popular history of Deep Time sees geoscience in continuous struggle with religious fundamentalism.展开更多
Subretinal injection is a complicated task for retinal surgeons to operate manually.In this paper we demonstrate a robust framework for needle detection and localisation in robotassisted subretinal injection using mic...Subretinal injection is a complicated task for retinal surgeons to operate manually.In this paper we demonstrate a robust framework for needle detection and localisation in robotassisted subretinal injection using microscope-integrated Optical Coherence Tomography with deep learning.Five convolutional neural networks with different architectures were evaluated.The main differences between the architectures are the amount of information they receive at the input layer.When evaluated on ex-vivo pig eyes,the top performing network successfully detected all needles in the dataset and localised them with an Intersection over Union value of 0.55.The algorithm was evaluated by comparing the depth of the top and bottom edge of the predicted bounding box to the ground truth.This analysis showed that the top edge can be used to predict the depth of the needle with a maximum error of 8.5μm.展开更多
The integration of artificial intelligence(AI)into medical robotics has emerged as a cornerstone of modern healthcare,driving transformative advancements in precision,adaptability and patient outcomes.Although computa...The integration of artificial intelligence(AI)into medical robotics has emerged as a cornerstone of modern healthcare,driving transformative advancements in precision,adaptability and patient outcomes.Although computational tools have long supported diagnostic processes,their role is evolving beyond passive assistance to become active collaborators in therapeutic decision-making.In this paradigm,knowledge-driven deep learning systems are redefining possibilities-enabling robots to interpret complex data,adapt to dynamic clinical environments and execute tasks with human-like contextual awareness.展开更多
To address challenges related to the intermittency of renewable energy sources,aqueous potassium-ion batteries(AKIBs)are a promising and sustainable alternative to conventional systems for large-scale energy storage.T...To address challenges related to the intermittency of renewable energy sources,aqueous potassium-ion batteries(AKIBs)are a promising and sustainable alternative to conventional systems for large-scale energy storage.To enable their practical application,maximizing energy density and longevity while minimizing production and material costs is a key goal.In this work,we propose an AKIB consisting only of abundant and cost-efficient materials,which delivers a high energy density of more than 70 Wh kg^(-1).We combine simple strategies to stabilize the Mn-rich Prussian blue analog cathode by Fe-doping,improving the crystallinity,and tuning the electrolyte composition without employing expensive water-in-salt electrolytes.Using a mixed 2.5 M Ca(NO_(3))_(2)+1.5 M KNO_(3)electrolyte,we assemble a novel AKIB with a Fe-doped manganese hexacyanoferrate cathode and an organic poly(naphthalene-4-formylethylenediamine)anode.Besides a high energy density,the full cell delivers a specific capacity of approximately 60 mAhg^(-1),a power density of 5000 W kg^(-1),and 80% capacity retention after 600 cycles.展开更多
We analyze the absorption features in the public 73 ks XMM-Newton spectra of the Seyfert 1 galaxy PG 0052+251.Our analysis reveals the presence of a warm absorber(WA)intrinsic to the source and the hot circumgalactic ...We analyze the absorption features in the public 73 ks XMM-Newton spectra of the Seyfert 1 galaxy PG 0052+251.Our analysis reveals the presence of a warm absorber(WA)intrinsic to the source and the hot circumgalactic medium at zero redshift.The identified WA is inflowing toward the central black hole,with a velocity shift of■.The ionization parameter of the WA is■,showing strong O II and O III absorption lines,along with a significant absorption of the spectral continuum at?10?.The line of sight toward PG 0052+251 intersects the halo of M31 at an impact parameter of approximately 218 kpc.Several local(z~0)absorption lines,like O VII,O VIII,and Ne IX,were detected.The derived hydrogen column density of the local hot gas is 2.2–2.6σhigher than those estimated by several models of the Galactic hot halo,suggesting a likely contribution from the M31 halo.We also find two absorption features at24.305?and 21.410?,which are unlikely to be associated with the hot halos or the warm-hot intergalactic medium but imply the presence of an additional WA component with an outflow velocity of approximately-7000 km s^(-1).展开更多
Cyclic loads generated by environmental factors,such as winds,waves,and trains,will likely lead to performance degradation in pile foundations,resulting in issues like permanent displacement accumulation and bearing c...Cyclic loads generated by environmental factors,such as winds,waves,and trains,will likely lead to performance degradation in pile foundations,resulting in issues like permanent displacement accumulation and bearing capacity attenuation.This paper presents a semi-analytical solution for predicting the axial cyclic behavior of piles in sands.The solution relies on two enhanced nonlinear load-transfer models considering stress-strain hysteresis and cyclic degradation in the pile-soil interaction.Model parameters are calibrated through cyclic shear tests of the sand-steel interface and laboratory geotechnical testing of sands.A novel aspect involves the meticulous formulation of the shaft loadtransfer function using an interface constitutive model,which inherently inherits the interface model’s advantages,such as capturing hysteresis,hardening,degradation,and particle breakage.The semi-analytical solution is computed numerically using the matrix displacement method,and the calculated values are validated through model tests performed on non-displacement and displacement piles in sands.The results demonstrate that the predicted values show excellent agreement with the measured values for both the static and cyclic responses of piles in sands.The displacement pile response,including factors such as bearing capacity,mobilized shaft resistance,and convergence rate of permanent settlement,exhibit improvements compared to non-displacement piles attributed to the soil squeezing effect.This methodology presents an innovative analytical framework,allowing for integrating cyclic interface models into the theoretical investigation of pile responses.展开更多
The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite interface.In this study,a novel microstructure-control technology is ...The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite interface.In this study,a novel microstructure-control technology is proposed for fabrication of porous NiO_(x)films using Pluronic P123 as the structure-directing agent and acetylacetone(AcAc)as the coordination agent.The synthesized porous NiO_(x)films enhanced the hole extraction efficiency and reduced recombination defects at the NiO_(x)/perovskite interface.Consequently,without any modification,the power conversion efficiency(PCE)of the PSC with MAPbl_(3)as the absorber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device composed of perovskite Cs0.05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous NiO_(x)on fluorine-doped tin oxide(FTO)substrates enabled the fabrication of large-area PSCs(1.2 cm^(2))with a PCE of 19.63%.This study provides a novel strategy for improving the contact at the NiO_(x)/perovskite interface for the fabrication of high-performance large-area perovskite solar cells.展开更多
Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues,including the skeletal and immune systems.Recent studies have elucidated the intricate ...Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues,including the skeletal and immune systems.Recent studies have elucidated the intricate bidirectional interactions between these two systems.展开更多
This research aims to generate processes of industrialization and qualification of social housing in Colombia through prefabrication,low energy consumption and high environmental quality to reduce the current deficit ...This research aims to generate processes of industrialization and qualification of social housing in Colombia through prefabrication,low energy consumption and high environmental quality to reduce the current deficit and improve the quality of life in communities with fewer economic resources.Modular coordination and the use of materials with thermal behaviors,appropriate to the country’s climatic characteristics,reduce production costs,avoid waste and improve the architectural and environmental quality of social housing.Passive cooling strategies,such as controlling solar incursion and generating natural cross ventilation eliminate energy consumption and allow reaching desired standards of comfort.In a context in which traditional construction systems have still not resolved the social housing deficit in Colombia and which generate high costs for energy consumption in the search for thermal comfort,industrialized and efficient construction with high environmental quality provides solutions according to the economic,geographic,social and cultural context in Colombia.展开更多
The growing demand for digital investment advisory services and the advancing technological process led to increased attention to this topic in recent literature.In light of these developments,the question arises whet...The growing demand for digital investment advisory services and the advancing technological process led to increased attention to this topic in recent literature.In light of these developments,the question arises whether conventional and digital advisors behave differently in their investment advisory decisions.I therefore conducted a systematic literature review and evaluated 97 publications on the determinants of conventional and digital investment advisory decisions.Based on the literature,five main determinants were identified that are important for investment advisory decisions.These determinants are identical for both variants of the advice,but there are differences in the way they are addressed.This systematic literature review provides an overview of the current state of research and can therefore help identify areas where investment advice can be improved in the future.展开更多
As the body’s integumentary system,the skin is vulnerable to injuries.The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality.To this end,multiple tissue-resident cells ...As the body’s integumentary system,the skin is vulnerable to injuries.The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality.To this end,multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue.Such temporally-and spatially-coordinated interplay necessitates tight regulation to prevent collateral damage such as overshooting immune responses and excessive inflammation.In this context,regulatory T cells(Tregs)hold a key role in balancing immune homeostasis and mediating cutaneous wound healing.A comprehensive understanding of Tregs’multifaceted field of activity may help decipher wound pathologies and,ultimately,establish new treatment modalities.Herein,we review the role of Tregs in orchestrating the regeneration of skin adnexa and catalyzing healthy wound repair.Further,we discuss how Tregs operate during fibrosis,keloidosis,and scarring.展开更多
Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of ...Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especially women,were more imprecise.Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity,irrespective of their level of occupational physical activity.展开更多
基金supported by the German Research Foundation(Deutsche Forschungsgemeinschaft)(DFG),project number 422179811 to RR and RA 689/12-1 to GR.
文摘The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce steroids.The main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.
文摘BACKGROUND Pancreatic cystic lesions are common in patients eligible for solid organ transplan-tation.It has been shown that the need for immunosuppression after organ transplantation increases the rate of malignancies in organ recipients.However,the impact of immunosuppression on pancreatic cystic lesions is yet unknown.AIM To evaluate the prevalence of pancreatic cystic lesions and the risk of cyst progression in immunosuppressed patients.METHODS A systematic literature search was performed in relevant databases.Studies reporting either on the prevalence and/or the incidence of pancreatic cyst progression compared to a control group were implemented in the first systematic review and meta-analysis on this topic.RESULTS The prevalence of pancreatic cystic lesions was comparable with 7%(95%CI:5%-11%)in the immunosuppressed cohort and 9%(95%CI:5%-16%)in the control cohort.The mean cyst size increase in the immunosuppression group was 3.2 mm(range 1.0-5.2mm)compared to 3.5 mm(1.0-6.9)in the control group(standar-dized mean difference 0.0 mm,95%CI:-0.3-0.2 mm,P=0.72).There was also no significant increase in the development of resection criteria or worrisome features under immunosuppression either[relative risk 1.1(fixed effect model),1.2(ran-dom effects model),P=0.61].CONCLUSION Immunosuppression does not increase the prevalence of pancreatic cystic lesions,nor does it increase the risk of cyst progression in terms of cyst size and development of resection criteria.Therefore,pancreatic cystic lesions in transplant candidates should not be a contraindication for solid organ transplantation.
文摘In popular history of science,we find the persistent narrative that traditionally Western Culture over centuries regarded the age of the Earth as brief-but a few thousand years old-and that it was scientific progress basically during the 19th century that extended this timescale against opposition from religious zealots to encompass millions of years and finally with radiometric dating to some 4.5 billion years.This popular history of Deep Time sees geoscience in continuous struggle with religious fundamentalism.
基金ZJU 100 Young Talent ProgramKey Program for Robot-assisted Subretinal Injection Research Center in Zhejiang Province,Grant/Award Number:2023ZY1061。
文摘Subretinal injection is a complicated task for retinal surgeons to operate manually.In this paper we demonstrate a robust framework for needle detection and localisation in robotassisted subretinal injection using microscope-integrated Optical Coherence Tomography with deep learning.Five convolutional neural networks with different architectures were evaluated.The main differences between the architectures are the amount of information they receive at the input layer.When evaluated on ex-vivo pig eyes,the top performing network successfully detected all needles in the dataset and localised them with an Intersection over Union value of 0.55.The algorithm was evaluated by comparing the depth of the top and bottom edge of the predicted bounding box to the ground truth.This analysis showed that the top edge can be used to predict the depth of the needle with a maximum error of 8.5μm.
文摘The integration of artificial intelligence(AI)into medical robotics has emerged as a cornerstone of modern healthcare,driving transformative advancements in precision,adaptability and patient outcomes.Although computational tools have long supported diagnostic processes,their role is evolving beyond passive assistance to become active collaborators in therapeutic decision-making.In this paradigm,knowledge-driven deep learning systems are redefining possibilities-enabling robots to interpret complex data,adapt to dynamic clinical environments and execute tasks with human-like contextual awareness.
基金Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under Germany’s Excellence Strategy-EXC 2089/1-390776260(e-conversion)for fundingfinancial support from TUM Innovation Network for Artificial Intelligence powered Multifunctional Material Design(ARTEMIS)。
文摘To address challenges related to the intermittency of renewable energy sources,aqueous potassium-ion batteries(AKIBs)are a promising and sustainable alternative to conventional systems for large-scale energy storage.To enable their practical application,maximizing energy density and longevity while minimizing production and material costs is a key goal.In this work,we propose an AKIB consisting only of abundant and cost-efficient materials,which delivers a high energy density of more than 70 Wh kg^(-1).We combine simple strategies to stabilize the Mn-rich Prussian blue analog cathode by Fe-doping,improving the crystallinity,and tuning the electrolyte composition without employing expensive water-in-salt electrolytes.Using a mixed 2.5 M Ca(NO_(3))_(2)+1.5 M KNO_(3)electrolyte,we assemble a novel AKIB with a Fe-doped manganese hexacyanoferrate cathode and an organic poly(naphthalene-4-formylethylenediamine)anode.Besides a high energy density,the full cell delivers a specific capacity of approximately 60 mAhg^(-1),a power density of 5000 W kg^(-1),and 80% capacity retention after 600 cycles.
基金supported by the National Natural Science Foundation of China under Nos.11890692,12133008 and 12221003We acknowledge the science research grant from the China Manned Space Project with No.CMS-CSST-2021-A04.
文摘We analyze the absorption features in the public 73 ks XMM-Newton spectra of the Seyfert 1 galaxy PG 0052+251.Our analysis reveals the presence of a warm absorber(WA)intrinsic to the source and the hot circumgalactic medium at zero redshift.The identified WA is inflowing toward the central black hole,with a velocity shift of■.The ionization parameter of the WA is■,showing strong O II and O III absorption lines,along with a significant absorption of the spectral continuum at?10?.The line of sight toward PG 0052+251 intersects the halo of M31 at an impact parameter of approximately 218 kpc.Several local(z~0)absorption lines,like O VII,O VIII,and Ne IX,were detected.The derived hydrogen column density of the local hot gas is 2.2–2.6σhigher than those estimated by several models of the Galactic hot halo,suggesting a likely contribution from the M31 halo.We also find two absorption features at24.305?and 21.410?,which are unlikely to be associated with the hot halos or the warm-hot intergalactic medium but imply the presence of an additional WA component with an outflow velocity of approximately-7000 km s^(-1).
基金the financial support provided by the National Natural Science Foundation of China(Grant No.42272310).
文摘Cyclic loads generated by environmental factors,such as winds,waves,and trains,will likely lead to performance degradation in pile foundations,resulting in issues like permanent displacement accumulation and bearing capacity attenuation.This paper presents a semi-analytical solution for predicting the axial cyclic behavior of piles in sands.The solution relies on two enhanced nonlinear load-transfer models considering stress-strain hysteresis and cyclic degradation in the pile-soil interaction.Model parameters are calibrated through cyclic shear tests of the sand-steel interface and laboratory geotechnical testing of sands.A novel aspect involves the meticulous formulation of the shaft loadtransfer function using an interface constitutive model,which inherently inherits the interface model’s advantages,such as capturing hysteresis,hardening,degradation,and particle breakage.The semi-analytical solution is computed numerically using the matrix displacement method,and the calculated values are validated through model tests performed on non-displacement and displacement piles in sands.The results demonstrate that the predicted values show excellent agreement with the measured values for both the static and cyclic responses of piles in sands.The displacement pile response,including factors such as bearing capacity,mobilized shaft resistance,and convergence rate of permanent settlement,exhibit improvements compared to non-displacement piles attributed to the soil squeezing effect.This methodology presents an innovative analytical framework,allowing for integrating cyclic interface models into the theoretical investigation of pile responses.
基金supported by the National Key Research and Development Program of China(grant no.2018YFA0208701)National Natural Science Foundation of China(grant no.21773308)+6 种基金Research Funds of Renmin University of China(grant nos.2017030013,201903020,and 20XNH059)Fundamental Research Funds for Central Universities(China)supported by the Solar Energy Research Institute of Singapore(SERIS)at the National University of Singapore(NUS)supported by NUS,the National Research Foundation Singapore(NRF),the Energy Market Authority of Singapore(EMA),and the Singapore Economic Development Board(EDB)the experimental support from Suzhou Fangsheng FS-300funding from Deutsche Forschungsge-meinschaft(DFG)via Germany's Excellence Strategy-EXC 2089/1-390776260(e-conversion)as well as from TUM.solar in the context of the Bavarian Collaborative Research Project Solar Technologies Go Hybrid(SoITech)the China Scholarship Council(CSC)funding
文摘The improvement in the efficiency of inverted perovskite solar cells(PSCs)is significantly limited by undesirable contact at the NiO_(x)/perovskite interface.In this study,a novel microstructure-control technology is proposed for fabrication of porous NiO_(x)films using Pluronic P123 as the structure-directing agent and acetylacetone(AcAc)as the coordination agent.The synthesized porous NiO_(x)films enhanced the hole extraction efficiency and reduced recombination defects at the NiO_(x)/perovskite interface.Consequently,without any modification,the power conversion efficiency(PCE)of the PSC with MAPbl_(3)as the absorber layer improved from 16.50%to 19.08%.Moreover,the PCE of the device composed of perovskite Cs0.05(MA_(0.15)FA_(0.85))_(0.95)Pb(I_(0.85)Br_(0.15))_(3)improved from 17.49%to 21.42%.Furthermore,the application of the fabricated porous NiO_(x)on fluorine-doped tin oxide(FTO)substrates enabled the fabrication of large-area PSCs(1.2 cm^(2))with a PCE of 19.63%.This study provides a novel strategy for improving the contact at the NiO_(x)/perovskite interface for the fabrication of high-performance large-area perovskite solar cells.
基金supported by the National Key R&D Program of China (2021YFA1101500)Wuhan Science and Technology Bureau (2022020801020464)+1 种基金partially supported by University Grants Committee,Research Grants Council of the Hong Kong Special Administrative Region,China (14113723,N_CUHK472/22,T13-402/17-N and AoE/M-402/20)Direct Grant of CUHK (2022.042)。
文摘Ageing as a natural irreversible process inherently results in the functional deterioration of numerous organ systems and tissues,including the skeletal and immune systems.Recent studies have elucidated the intricate bidirectional interactions between these two systems.
文摘This research aims to generate processes of industrialization and qualification of social housing in Colombia through prefabrication,low energy consumption and high environmental quality to reduce the current deficit and improve the quality of life in communities with fewer economic resources.Modular coordination and the use of materials with thermal behaviors,appropriate to the country’s climatic characteristics,reduce production costs,avoid waste and improve the architectural and environmental quality of social housing.Passive cooling strategies,such as controlling solar incursion and generating natural cross ventilation eliminate energy consumption and allow reaching desired standards of comfort.In a context in which traditional construction systems have still not resolved the social housing deficit in Colombia and which generate high costs for energy consumption in the search for thermal comfort,industrialized and efficient construction with high environmental quality provides solutions according to the economic,geographic,social and cultural context in Colombia.
文摘The growing demand for digital investment advisory services and the advancing technological process led to increased attention to this topic in recent literature.In light of these developments,the question arises whether conventional and digital advisors behave differently in their investment advisory decisions.I therefore conducted a systematic literature review and evaluated 97 publications on the determinants of conventional and digital investment advisory decisions.Based on the literature,five main determinants were identified that are important for investment advisory decisions.These determinants are identical for both variants of the advice,but there are differences in the way they are addressed.This systematic literature review provides an overview of the current state of research and can therefore help identify areas where investment advice can be improved in the future.
文摘As the body’s integumentary system,the skin is vulnerable to injuries.The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality.To this end,multiple tissue-resident cells and recruited immune cells cooperate to efficiently repair the injured tissue.Such temporally-and spatially-coordinated interplay necessitates tight regulation to prevent collateral damage such as overshooting immune responses and excessive inflammation.In this context,regulatory T cells(Tregs)hold a key role in balancing immune homeostasis and mediating cutaneous wound healing.A comprehensive understanding of Tregs’multifaceted field of activity may help decipher wound pathologies and,ultimately,establish new treatment modalities.Herein,we review the role of Tregs in orchestrating the regeneration of skin adnexa and catalyzing healthy wound repair.Further,we discuss how Tregs operate during fibrosis,keloidosis,and scarring.
基金The Trùndelag Health Study (HUNT) is a collaboration between HUNT Research Centre (Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology), Trùndelag County Council, Central Norway Regional Health Authority, and the Norwegian Institute of Public HealthThe coordination of European Prospective Investigation into Cancer and Nutrition - Spain study (EPIC) is financially supported by the International Agency for Research on Cancer (IARC)+7 种基金by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC)supported by Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII), Regional Governments of Andaluc 1a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology - ICO (Spain)funded by The Netherlands Organisation for Health Research and DevelopmentZon Mw (Grant No.: 531-00141-3)Funding for the SHIP study has been provided by the Federal Ministry for Education and Research (BMBFidentification codes 01 ZZ96030, 01 ZZ0103, and 01 ZZ0701)support from the Swedish Research Council (2018-02527 and 2019-00193)financed by the Helmholtz Zentrum München - German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria.
文摘Background There is insufficient evidence to provide recommendations for leisure-time physical activity among workers across various occupational physical activity levels.This study aimed to assess the association of leisure-time physical activity with cardiovascular and all-cause mortality across occupational physical activity levels.Methods This study utilized individual participant data from 21 cohort studies,comprising both published and unpublished data.Eligibility criteria included individual-level data on leisure-time and occupational physical activity(categorized as sedentary,low,moderate,and high)along with data on all-cause and/or cardiovascular mortality.A 2-stage individual participant data meta-analysis was conducted,with separate analysis of each study using Cox proportional hazards models(Stage 1).These results were combined using random-effects models(Stage 2).Results Higher leisure-time physical activity levels were associated with lower all-cause and cardiovascular mortality risk across most occupational physical activity levels,for both males and females.Among males with sedentary work,high compared to sedentary leisure-time physical activity was associated with lower all-cause(hazard ratios(HR)=0.77,95%confidence interval(95%CI):0.70-0.85)and cardiovascular mortality(HR=0.76,95%CI:0.66-0.87)risk.Among males with high levels of occupational physical activity,high compared to sedentary leisure-time physical activity was associated with lower all-cause(HR=0.84,95%CI:0.74-0.97)and cardiovascular mortality(HR=0.79,95%CI:0.60-1.04)risk,while HRs for low and moderate levels of leisure-time physical activity ranged between 0.87 and 0.97 and were not statistically significant.Among females,most effects were similar but more imprecise,especially in the higher occupational physical activity levels.Conclusion Higher levels of leisure-time physical activity were generally associated with lower mortality risks.However,results for workers with moderate and high occupational physical activity levels,especially women,were more imprecise.Our findings suggests that workers may benefit from engaging in high levels of leisure-time physical activity,irrespective of their level of occupational physical activity.
