Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)...Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)cases,highlighting an urgent need to discover new therapeutic targets.This study aims to elucidate the mechanisms underlying poor prognosis in Ph+/Ph-like ALL through transcriptome sequencing and functional cytological assays,with the goal of informing new clinical treatment strategies.Results:Transcriptomic analysis of Ph+/Ph-like ALL patients revealed that low expression of P2X Purinoceptor 1(P2RX1)was associated with unfavorable outcomes.Specifically,patients with poor prognosis and low P2RX1 expression exhibited downregulation of genes involved in energy and calcium metabolism pathways,along with upregulation of genes governing key cellular processes such as cell proliferation(e.g.,MYC),cell cycle progression(e.g.,CCND2),and apoptosis inhibition(e.g.,DASP6).Cellular experiments demonstrated that SUP-B15 cells overexpressing P2RX1 displayed elevated intracellular levels of ATP,calcium,and glucose,together with enhanced glycolytic capacity,compared to empty vector controls.Treatment of SUP-B15 cells with dexamethasone(Dex),Imatinib,or their combination significantly suppressed proliferation and promoted apoptosis,which was accompanied by increases in intracellular ATP,calcium,and glucose.Moreover,exogenous ATP administration(a P2RX1 agonist)enhanced apoptosis and inhibited proliferation in control cells.Conversely,treatment with NF449(a P2RX1 inhibitor)increased proliferation in both P2RX1-overexpressing and control SUP-B15 cells.Conclusion:Our findings indicate that P2RX1 may exert this function through modulating energy metabolism and calcium homeostasis,resulting in elevated intracellular calcium levels.Sustained elevation of calcium promotes apoptosis,whereas exogenous ATP activates P2RX1,enhances calcium influx,and attenuates the suppression of apoptosis associated with P2RX1 underexpression,ultimately correlating with improved treatment response.展开更多
AIM:To investigate the efficacy and safety of repeated dexamethasone implants with real-life data in eyes with naive retinal vein occlusion(RVO)with macular edema(ME)at a minimum of 60mo follow-up.METHODS:In this retr...AIM:To investigate the efficacy and safety of repeated dexamethasone implants with real-life data in eyes with naive retinal vein occlusion(RVO)with macular edema(ME)at a minimum of 60mo follow-up.METHODS:In this retrospective cohort study,the data about best corrected visual acuity(BCVA),central macular thickness(CMT),serous macular detachment(SMD),hard exudate,hyperreflective foci(HRF),cystoid degeneration,pearl necklace sign,epiretinal membrane(ERM),disorganization of retinal inner layers(DRIL),ellipsoid zone and external limiting membrane(EZ-ELM)integrity,intraocular pressure(IOP)and lens condition were recorded.RESULTS:Thirty-eight eyes of 38 patients were included in the study.Thirteen patients presented with central RVO(CRVO)and 25 with branch RVO(BRVO).The mean follow-up time was 69.9±15.8mo,and the mean number of injections was 7.9±4.0.The mean BCVA gain was 25.0±36 letters,and this difference was statistically significant(P=0.021).The BCVA gain was 19.4±20.4 letters in the CRVO group,and 26.5±38.6 letters in the BRVO group(P=0.763).Besides,21(55.2%)of the patients achieved≥15 letters improvement.At the end of the follow-up period,SMD was not observed in any of the patients(P=0.016).Hard exudate,HRF number were decreased;while DRIL,ERM and EZ-ELM defects were increased but not significantly.CONCLUSION:Intravitreal dexamethasone monotherapy is an effective and safe treatment option for the treatment-naive RVO-ME patients in the long-term follow-up.展开更多
The organic fluorescent probes were widely explored for specific detection of chemical nerve agent simulants.However,the fluorescence quenching,long-time response,and limitation of detection further impeded their prac...The organic fluorescent probes were widely explored for specific detection of chemical nerve agent simulants.However,the fluorescence quenching,long-time response,and limitation of detection further impeded their practical applications.Herein,the fluorescent nanofiber chitosan-1 was prepared through the modification of chitosan with 1,8-naphthalimide as fluorophore and piperazine as the detection segment.The high specific surface of fluorescent nanofiber chitosan-1 showed ultrasensitive and selective detection of diethyl chlorophosphate(DCP)in solution and vapor.The satisfied linear relationship between the fluorescent intensity and the concentration of DCP ranging from 0μmol/L to 100μmol/L was obtained.The limitation of detection was measured as low as 2.2 nmol/L within 30 s.The sensing mechanism was explored through the photoinduced electron transfer(PET)mechanism which was confirmed by ^(1)H,^(31)P NMR,and mass spectra(MS).The ultrasensitive detection of nanofibers may provide valuable insights for enhancing the sensing performance in visually detecting chemical nerve agents.展开更多
We present a comprehensive analysis of BI CVn,an eclipsing overcontact binary system.New BVR photometric observations,combined with available spectroscopic data,were analyzed simultaneously using the Wilson–Devinney ...We present a comprehensive analysis of BI CVn,an eclipsing overcontact binary system.New BVR photometric observations,combined with available spectroscopic data,were analyzed simultaneously using the Wilson–Devinney method to derive the orbital and physical parameters of the system.The resulting stellar parameters are M1=0.58±0.01M⊙,M2=1.42±0.02M⊙,R1=0.88±0.01R⊙,R2=1.31±0.01R⊙,with an orbital separation of a=2.80±0.01R⊙.Based on all available CCD times of minimum light,including both ground-based and T ESS observations,the(O-C)diagram of BI CVn was analyzed.T he orbital period exhibits a long-term decrease at a rate of-2.3239(±0.0001)×10-8 day yr-1,likely due to mass transfer from the more massive to the less massive component.Superimposed on this trend is a cyclic variation with a period of 56.84±0.08 yr,indicative of a light-travel time effect caused by a third body,whose estimated mass is 0.63±0.02M⊙.Using these derived parameters,we modeled the binary’s evolution through non-conservative processes with the Binary Star Evolution code.The evolutionary tracks of the components were examined in multiple parameter planes,leading to an estimated merger timescale of approximately 2.70 Gyr.展开更多
[Objectives]The paper was to figure out the distribution of Monochamus alternatus in the stumps of pine wood nematode infected wood in Lu'an City and to provide a theoretical and practical basis for differentiated...[Objectives]The paper was to figure out the distribution of Monochamus alternatus in the stumps of pine wood nematode infected wood in Lu'an City and to provide a theoretical and practical basis for differentiated prevention and control of pine wood nematode disease in the future.[Methods]The factors influencing the number of epidemic small classes and infected plants in all counties and districts of Lu'an City were analyzed by GIS method,and the number of worms and wormholes of M.alternatus inside and outside the stumps of pine wood nematode infected wood in Lu'an City were investigated on the spot.[Results]There were 98,40,54,781,193,268 and 34 epidemic small classes of pine wood nematode disease,and 7241,6099,9532,39161,11079,49876 and 4853 infected plants in Yu'an District,Jin'an District,Yeji District,Shucheng County,Huoshan County,Jinzhai County and Huoqiu County,respectively.Pine wood nematode disease in Lu'an City mostly occurred in Huoshan County,Shucheng County and Jinzhai County,with relatively high altitude,paddy soil,the annual precipitation higher than 2062 mm,and the annual average temperature lower than 16.2℃.The number of diseased plants of pine wood nematode disease was positively correlated with altitude and annual precipitation,and was negatively correlated with annual average temperature.The number of worms and wormholes in pine wood nematode infected wood was very small at different altitudes,stump heights and stump diameters.[Conclusions]The pine wood nematode infected wood can be differentially processed after stump treatment,and stumps can be peeled.The results will provide a theoretical and practical basis for differentiated prevention and control of pine wood nematode disease in the future.展开更多
BackgroundGrowth differentiation factor （GDF）-15, a divergent member of the transforming growth factor beta super-family does appear to be up-regulated in response to experimental pressure overload and progression o...BackgroundGrowth differentiation factor （GDF）-15, a divergent member of the transforming growth factor beta super-family does appear to be up-regulated in response to experimental pressure overload and progression of heart failure （HF）. HF frequently develops after myocardial infarction （MI）, contributing to worse outcome. The aim of this study is to assess the correlation between GDF-15 levels and markers related to collagen turnover in different stages of HF.MethodsThe study consists of a cohort of 179 patients, including stable angina pectoris patients （AP group,n= 50）, old MI patients without HF （OMI group,n = 56）, old MI patients with HF （OMI-HF group,n= 38） and normal Control group （n = 35）. Both indicators reflecting the synthesis and degradation rates of collagen including precollagen I N-terminal peptide （PINP）, type I collagen carboxy-terminal peptide （ICTP）, precollagen III N-terminal peptide （PIIINP） and GDF-15 were measured using an enzyme-linked inmunosorbent assay.ResultsThe plasma GDF-15 level was higher in OMI-HF group （1373.4 ± 275.4 ng/L） than OMI group （1036.1 ± 248.6 ng/L）, AP group （784.6 ± 222.4 ng/L） and Control group （483.8 ± 186.4 ng/L） （P〈 0.001）. The indi-cators of collagen turnover （ICTP, PINP, PIIINP） all increased in the OMI-HF group compared with Control group （3.03 ± 1.02μg/Lvs. 2.08 ± 0.95μg/L, 22.2 ± 6.6μg/Lvs. 16.7 ± 5.1μg/L and 13.2 ± 7.9μg/Lvs. 6.4 ± 2.1μg/L, respectively;P〈 0.01）. GDF-15 positively cor-related with ICTP and PIIINP （r = 0.302,P〈 0.001 andr= 0.206,P= 0.006, respectively）. GDF-15 positively correlated to the echocardio-graphic diastolic indicators E/Em and left atrial pressure （r= 0.349 and r= 0.358, respectively;P〈 0.01）, and inversely correlated to the systolic indicators left ventricular ejection fraction and the average of peak systolic myocardial velocities （Sm） （r=-0.623 and r=-0.365, respectively;P〈 0.01）.ConclusionPlasma GDF-15 is associated with the indicators of type I and III collagen turnover.展开更多
We present a novel protocol for deterministic secure quantum communication by using the lour-qubit cluster state as quantum channel. It is shown that two legitimate users can directly transmit the secret messages base...We present a novel protocol for deterministic secure quantum communication by using the lour-qubit cluster state as quantum channel. It is shown that two legitimate users can directly transmit the secret messages based on Bellbasis measurements and classical communication. The present protocol makes use of the ideas of block transmission and decoy particle checking technique. It has a high capacity as each cluster state can carry two 5its of information, and has a high intrinsic efficieney 5ecause almost all the instances except the decoy checking particles （its numSer is negligible） are useful. Furthermore, this protocol is feasible with present-day technique.展开更多
The chiral oxiranecarboxylic acids or esters 2a-e were obtained with lipase (CCL) in aqueous-organic system.The ee and the absolute configurations of the products were determined.
Using 1,1-bis(isoquinoline)-1,4-phenyldimethylenyl(BIQPM^(2+))cation as template,a new tetrameric(Bi_(4)I_(16))^(4-)-iodobismuthate-containing hybrid with formula of(BIQPM)_(2)(Bi_(4)I_(16)·H_(2)O(1),has been pre...Using 1,1-bis(isoquinoline)-1,4-phenyldimethylenyl(BIQPM^(2+))cation as template,a new tetrameric(Bi_(4)I_(16))^(4-)-iodobismuthate-containing hybrid with formula of(BIQPM)_(2)(Bi_(4)I_(16)·H_(2)O(1),has been prepared under solvothermal conditions.The centrosymmetric (Bi_(4)I_(16))^(4- ) tetraanion is constructed from four edge-shared slightly distorted BiI6 octahedrons.Due to the presence of larger conjugated system(isoquinoline ring),strongπ···πstacking interactions can be observed.Besides,strong I···I interactions can be monitored and extends the 0-D (Bi_(4)I_(16))^(4- )cluster to a quasi-1-D chain.The smaller energy gap of 2.13 eV is led by these non-covalent interactions.Its infrared emission might be caused by strong charge transfer between anions and cations.Furthermore,the reversible thermochromic behavior with low chromotropic temperature of 80℃can be observed,whose mechanism was discussed.展开更多
Background:Potassium(K)deficiency has become a common field production problem following the widespread adoption of Bacillus thuringiensis(Bt)transgenic cotton(Gossypium hirsutum L.)worldwide.The purpose of this study...Background:Potassium(K)deficiency has become a common field production problem following the widespread adoption of Bacillus thuringiensis(Bt)transgenic cotton(Gossypium hirsutum L.)worldwide.The purpose of this study was to clarify whether the introduction of Bt gene directly reduces the K-use efficiency of cotton to induce K deficiency.Results:The cotton variety,Jihe 321(wild type,WT)and its two Bt(Cry1Ac)-transgenic overexpression lines(OE-29317,OE-29312)were studied in field with low soil-test K+(47.8 mg·kg^(−1)).In the field with low soil-test K+,only OE-29317 had less biomass and K+accumulation than the WT at some growth stages.Both Bt lines produced similar or even greater seed cotton yield than WT in the field.When the Bt gene(~70%)in OE-29317 and OE-29312 plants was silenced by virus-induced gene silencing(VIGS),the VIGS-Bt plants did not produce more biomass than VIGSgreen fluorescent protein(control)plants.Conclusions:The introduction of Bt gene did not necessarily hinder the K use efficiency of the cotton lines under this study.展开更多
Palladium-catalyzed coupling of trifluorovinylzinc reagent with substituted aryl halides Y-C_6H_4-X (Y=p-NO_2, p-and m-COOMe, p-COOH, p-CONH_2, p- and m-CN; X=Br, I, Cl) provides a synthetic method for α, β, β-trif...Palladium-catalyzed coupling of trifluorovinylzinc reagent with substituted aryl halides Y-C_6H_4-X (Y=p-NO_2, p-and m-COOMe, p-COOH, p-CONH_2, p- and m-CN; X=Br, I, Cl) provides a synthetic method for α, β, β-trifluorostyrenes(Y-TFS's). A series of previously unavailable Y-TFS's were thus obtained.展开更多
BACKGROUND Lung cancer is increasing in incidence worldwide,and targeted therapies are developing at a rapid pace.Furthermore,the KRAS specific gene is strongly associated with non-small cell lung cancer(NSCLC).Adult ...BACKGROUND Lung cancer is increasing in incidence worldwide,and targeted therapies are developing at a rapid pace.Furthermore,the KRAS specific gene is strongly associated with non-small cell lung cancer(NSCLC).Adult patients with locally advanced or metastatic NSCLC who have tested positive for the KRAS G12C mutation and have progressed after at least one systemic treatment are treated with sotorasib.CASE SUMMARY In this study,we report on an advanced NSCLC with a KRAS G12C mutation.The histological diagnosis indicates stage IVB left lung adenocarcinoma with pelvic and bone metastases,identified as cT4N2bM1c.Using circulating tumor DNA analysis,it was possible to determine the mutation abundance of the KRAS gene exon 2,c.34G>Tp.G12C,which was 32.3%.The patient was advised to take sotorasib as part of their treatment.The imaging data were compared before and after treatment.Furthermore,clinical reassessments and regular serial blood testing were conducted.We found that the patient’s clinical symptoms significantly improved after receiving sotorasib medication,and there were no notable side effects,such as liver toxicity,during the treatment.CONCLUSION Sotorasib has shown promising clinical efficacy in patients with the KRAS G12c mutation and has no apparent toxic side effects.展开更多
Purpose:Digitoxin is a cardiac glycoside used in the treatment of heart failure.Inspired by its known antiinflammatory effect,this study aims to investigate the effect of digoxin in a sepsis model and to bring to ligh...Purpose:Digitoxin is a cardiac glycoside used in the treatment of heart failure.Inspired by its known antiinflammatory effect,this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury(ALI).Method:28 wistar albino rats were divided into 4 groups.Sepsis model is performed by the feces intraperitoneal-injection procedure(FIP).Results:TNF-a,CRP,IL-6,IL 1-Beta,lactic acid,and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group.When the same groups were examined,histological improvements such as decrease in alveolar inflammation and decrease in septal thickening in the digitoxin group and thorax CT were found to be significantly higher in the Hounsfield unit digitoxin group compared to the Saline group.Conclusion:Digitoxin has shown biochemical improvement in sepsis with all known mechanisms of action,and healing effects in both computerized tomography and histology in the lung.展开更多
The optically active R-4-phenyl-2-hydroxy butyrates were prepared by esterification of the racemic acid or transesterification of the racemic ester catalyzed by lipase from Candida cyclindra (CCL) in organic media.
Polyfluoroalkylated biphenyl was obtained from reaction of benzene with R_FI/Na_2S_2O_4 using cetyltrimethylammonium bromide (CTAB) as PTC followed by dehydrogenation with DDQ in 38-43% yield.
During COVID-19,the repercussions on scholar dynamics,functioning and structure were inevitable,causing an impact on groups that,historically,are minority in relation to the scope of school inclusion policies,such as ...During COVID-19,the repercussions on scholar dynamics,functioning and structure were inevitable,causing an impact on groups that,historically,are minority in relation to the scope of school inclusion policies,such as students diagnosed with autism spectrum disorder(ASD).This scenario is followed by educational phenomena in the face of which School Psychology has collaborated with the advancement of research and knowledge production.This qualitative study,based on Historical-Cultural Psychology and Critical School Psychology,analyzed the role of the school psychologist in monitoring students diagnosed with ASD in the context of regular school during the pandemic.The following procedures were conducted:application of an online questionnaire;and semi-structured interviews with four school psychologists.As a result,three zones of shared meanings were built:the claim for the right to education with support and adaptations;the psychologist as the great savior of inclusion;the non-total inclusion that denounces the structure of injustice by school.The information suggests that professional performance was hampered by different obstacles in the pandemic,such as the difficulty imposed by school,overload of demands,and impasses in the implementation of inclusion historically experienced at school,revealing that the school structure still carries historical consequences of exclusion.These shared meanings have demanded a professional performance with more effort,resistance,and strategies that accept the demands of school inclusion,providing collective mobilization,together with school actors,capable of breaking down barriers,especially those related to capacitist concepts.展开更多
Perfluoroalkylbenzo crown ethers were readily prepared from the reaction of benzo crown ethers with sodium perfluoroalkanesulfinates in the presence of an oxidizing agent such as Ce(SO_4)_2 or Mn(OAC)_3.2H_2O in good ...Perfluoroalkylbenzo crown ethers were readily prepared from the reaction of benzo crown ethers with sodium perfluoroalkanesulfinates in the presence of an oxidizing agent such as Ce(SO_4)_2 or Mn(OAC)_3.2H_2O in good yields through a radical process.展开更多
Taking college mathematics as an example,a questionnaire was designed for college mathematics teachers and students to fully comprehend the teaching situation.This paper mainly discusses the problems existing in the t...Taking college mathematics as an example,a questionnaire was designed for college mathematics teachers and students to fully comprehend the teaching situation.This paper mainly discusses the problems existing in the teaching of college mathematics and proposes the strategy of integrating PBL with curriculum ideological and political elements in college mathematics,so as to change the teaching process and improve the teaching quality.展开更多
基金supported by Guangdong Province Basic and Applied Basic Research Fund Project(2023A1515220104)Open Fund of Key Laboratory of Hepatoaplenic Surgery,Ministry of Education(Award Number:GPKF202407).
文摘Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)cases,highlighting an urgent need to discover new therapeutic targets.This study aims to elucidate the mechanisms underlying poor prognosis in Ph+/Ph-like ALL through transcriptome sequencing and functional cytological assays,with the goal of informing new clinical treatment strategies.Results:Transcriptomic analysis of Ph+/Ph-like ALL patients revealed that low expression of P2X Purinoceptor 1(P2RX1)was associated with unfavorable outcomes.Specifically,patients with poor prognosis and low P2RX1 expression exhibited downregulation of genes involved in energy and calcium metabolism pathways,along with upregulation of genes governing key cellular processes such as cell proliferation(e.g.,MYC),cell cycle progression(e.g.,CCND2),and apoptosis inhibition(e.g.,DASP6).Cellular experiments demonstrated that SUP-B15 cells overexpressing P2RX1 displayed elevated intracellular levels of ATP,calcium,and glucose,together with enhanced glycolytic capacity,compared to empty vector controls.Treatment of SUP-B15 cells with dexamethasone(Dex),Imatinib,or their combination significantly suppressed proliferation and promoted apoptosis,which was accompanied by increases in intracellular ATP,calcium,and glucose.Moreover,exogenous ATP administration(a P2RX1 agonist)enhanced apoptosis and inhibited proliferation in control cells.Conversely,treatment with NF449(a P2RX1 inhibitor)increased proliferation in both P2RX1-overexpressing and control SUP-B15 cells.Conclusion:Our findings indicate that P2RX1 may exert this function through modulating energy metabolism and calcium homeostasis,resulting in elevated intracellular calcium levels.Sustained elevation of calcium promotes apoptosis,whereas exogenous ATP activates P2RX1,enhances calcium influx,and attenuates the suppression of apoptosis associated with P2RX1 underexpression,ultimately correlating with improved treatment response.
文摘AIM:To investigate the efficacy and safety of repeated dexamethasone implants with real-life data in eyes with naive retinal vein occlusion(RVO)with macular edema(ME)at a minimum of 60mo follow-up.METHODS:In this retrospective cohort study,the data about best corrected visual acuity(BCVA),central macular thickness(CMT),serous macular detachment(SMD),hard exudate,hyperreflective foci(HRF),cystoid degeneration,pearl necklace sign,epiretinal membrane(ERM),disorganization of retinal inner layers(DRIL),ellipsoid zone and external limiting membrane(EZ-ELM)integrity,intraocular pressure(IOP)and lens condition were recorded.RESULTS:Thirty-eight eyes of 38 patients were included in the study.Thirteen patients presented with central RVO(CRVO)and 25 with branch RVO(BRVO).The mean follow-up time was 69.9±15.8mo,and the mean number of injections was 7.9±4.0.The mean BCVA gain was 25.0±36 letters,and this difference was statistically significant(P=0.021).The BCVA gain was 19.4±20.4 letters in the CRVO group,and 26.5±38.6 letters in the BRVO group(P=0.763).Besides,21(55.2%)of the patients achieved≥15 letters improvement.At the end of the follow-up period,SMD was not observed in any of the patients(P=0.016).Hard exudate,HRF number were decreased;while DRIL,ERM and EZ-ELM defects were increased but not significantly.CONCLUSION:Intravitreal dexamethasone monotherapy is an effective and safe treatment option for the treatment-naive RVO-ME patients in the long-term follow-up.
基金financial support from the National Natural Science Foundation of China(Nos.82104065,32061143045,22276142,22474003)the National Key Research&Development Program(Nos.2019YFE0123100,2022YFE0199800)+2 种基金Anhui Provincial Natural Science Foundation(No.2208085MB38)Anhui Provincial Natural Science Foundation for Distinguished Young Scholars(No.2008085J11)Foundation of Education Department of Anhui Province(No.2022AH010023).
文摘The organic fluorescent probes were widely explored for specific detection of chemical nerve agent simulants.However,the fluorescence quenching,long-time response,and limitation of detection further impeded their practical applications.Herein,the fluorescent nanofiber chitosan-1 was prepared through the modification of chitosan with 1,8-naphthalimide as fluorophore and piperazine as the detection segment.The high specific surface of fluorescent nanofiber chitosan-1 showed ultrasensitive and selective detection of diethyl chlorophosphate(DCP)in solution and vapor.The satisfied linear relationship between the fluorescent intensity and the concentration of DCP ranging from 0μmol/L to 100μmol/L was obtained.The limitation of detection was measured as low as 2.2 nmol/L within 30 s.The sensing mechanism was explored through the photoinduced electron transfer(PET)mechanism which was confirmed by ^(1)H,^(31)P NMR,and mass spectra(MS).The ultrasensitive detection of nanofibers may provide valuable insights for enhancing the sensing performance in visually detecting chemical nerve agents.
基金a project supported by the Scientific and Technological Research Council of Türkiye (TüB?TAK) under grant No.114F166
文摘We present a comprehensive analysis of BI CVn,an eclipsing overcontact binary system.New BVR photometric observations,combined with available spectroscopic data,were analyzed simultaneously using the Wilson–Devinney method to derive the orbital and physical parameters of the system.The resulting stellar parameters are M1=0.58±0.01M⊙,M2=1.42±0.02M⊙,R1=0.88±0.01R⊙,R2=1.31±0.01R⊙,with an orbital separation of a=2.80±0.01R⊙.Based on all available CCD times of minimum light,including both ground-based and T ESS observations,the(O-C)diagram of BI CVn was analyzed.T he orbital period exhibits a long-term decrease at a rate of-2.3239(±0.0001)×10-8 day yr-1,likely due to mass transfer from the more massive to the less massive component.Superimposed on this trend is a cyclic variation with a period of 56.84±0.08 yr,indicative of a light-travel time effect caused by a third body,whose estimated mass is 0.63±0.02M⊙.Using these derived parameters,we modeled the binary’s evolution through non-conservative processes with the Binary Star Evolution code.The evolutionary tracks of the components were examined in multiple parameter planes,leading to an estimated merger timescale of approximately 2.70 Gyr.
基金Supported by Youth Project of Natural Science Foundation of Anhui Province(2008085QC135)Postdoctoral Workstation Project of West Anhui University(WXBSH2020003)+4 种基金Key Program of Natural Science Research Project for Anhui Universities(KJ2021A0954)Forestry Carbon Sequestration Self-funded Science and Technology Project of Anhui Province(LJH[2022]267)Key School-level Nature Research Project of West Anhui University(WXZR202020)Subject of Lu'an Forestry Bureau(0045021093)Provincial Quality Engineering Project of West Anhui University(2022jyxm1765).
文摘[Objectives]The paper was to figure out the distribution of Monochamus alternatus in the stumps of pine wood nematode infected wood in Lu'an City and to provide a theoretical and practical basis for differentiated prevention and control of pine wood nematode disease in the future.[Methods]The factors influencing the number of epidemic small classes and infected plants in all counties and districts of Lu'an City were analyzed by GIS method,and the number of worms and wormholes of M.alternatus inside and outside the stumps of pine wood nematode infected wood in Lu'an City were investigated on the spot.[Results]There were 98,40,54,781,193,268 and 34 epidemic small classes of pine wood nematode disease,and 7241,6099,9532,39161,11079,49876 and 4853 infected plants in Yu'an District,Jin'an District,Yeji District,Shucheng County,Huoshan County,Jinzhai County and Huoqiu County,respectively.Pine wood nematode disease in Lu'an City mostly occurred in Huoshan County,Shucheng County and Jinzhai County,with relatively high altitude,paddy soil,the annual precipitation higher than 2062 mm,and the annual average temperature lower than 16.2℃.The number of diseased plants of pine wood nematode disease was positively correlated with altitude and annual precipitation,and was negatively correlated with annual average temperature.The number of worms and wormholes in pine wood nematode infected wood was very small at different altitudes,stump heights and stump diameters.[Conclusions]The pine wood nematode infected wood can be differentially processed after stump treatment,and stumps can be peeled.The results will provide a theoretical and practical basis for differentiated prevention and control of pine wood nematode disease in the future.
基金All authors have no conflict of interest regarding this paper. This work was supported by Grant National Natural Science Foundation of China （81400262） ＆ Backbone Fund of Peking University Third Hospital.
文摘BackgroundGrowth differentiation factor （GDF）-15, a divergent member of the transforming growth factor beta super-family does appear to be up-regulated in response to experimental pressure overload and progression of heart failure （HF）. HF frequently develops after myocardial infarction （MI）, contributing to worse outcome. The aim of this study is to assess the correlation between GDF-15 levels and markers related to collagen turnover in different stages of HF.MethodsThe study consists of a cohort of 179 patients, including stable angina pectoris patients （AP group,n= 50）, old MI patients without HF （OMI group,n = 56）, old MI patients with HF （OMI-HF group,n= 38） and normal Control group （n = 35）. Both indicators reflecting the synthesis and degradation rates of collagen including precollagen I N-terminal peptide （PINP）, type I collagen carboxy-terminal peptide （ICTP）, precollagen III N-terminal peptide （PIIINP） and GDF-15 were measured using an enzyme-linked inmunosorbent assay.ResultsThe plasma GDF-15 level was higher in OMI-HF group （1373.4 ± 275.4 ng/L） than OMI group （1036.1 ± 248.6 ng/L）, AP group （784.6 ± 222.4 ng/L） and Control group （483.8 ± 186.4 ng/L） （P〈 0.001）. The indi-cators of collagen turnover （ICTP, PINP, PIIINP） all increased in the OMI-HF group compared with Control group （3.03 ± 1.02μg/Lvs. 2.08 ± 0.95μg/L, 22.2 ± 6.6μg/Lvs. 16.7 ± 5.1μg/L and 13.2 ± 7.9μg/Lvs. 6.4 ± 2.1μg/L, respectively;P〈 0.01）. GDF-15 positively cor-related with ICTP and PIIINP （r = 0.302,P〈 0.001 andr= 0.206,P= 0.006, respectively）. GDF-15 positively correlated to the echocardio-graphic diastolic indicators E/Em and left atrial pressure （r= 0.349 and r= 0.358, respectively;P〈 0.01）, and inversely correlated to the systolic indicators left ventricular ejection fraction and the average of peak systolic myocardial velocities （Sm） （r=-0.623 and r=-0.365, respectively;P〈 0.01）.ConclusionPlasma GDF-15 is associated with the indicators of type I and III collagen turnover.
基金supported by the Postgraduate Innovation Research Plan from Anhui University under Grant No.20073039
文摘We present a novel protocol for deterministic secure quantum communication by using the lour-qubit cluster state as quantum channel. It is shown that two legitimate users can directly transmit the secret messages based on Bellbasis measurements and classical communication. The present protocol makes use of the ideas of block transmission and decoy particle checking technique. It has a high capacity as each cluster state can carry two 5its of information, and has a high intrinsic efficieney 5ecause almost all the instances except the decoy checking particles （its numSer is negligible） are useful. Furthermore, this protocol is feasible with present-day technique.
文摘The chiral oxiranecarboxylic acids or esters 2a-e were obtained with lipase (CCL) in aqueous-organic system.The ee and the absolute configurations of the products were determined.
基金financially supported by the Teaching Quality Project of West Anhui Health Vocational College(YJZLGC201713)
文摘Using 1,1-bis(isoquinoline)-1,4-phenyldimethylenyl(BIQPM^(2+))cation as template,a new tetrameric(Bi_(4)I_(16))^(4-)-iodobismuthate-containing hybrid with formula of(BIQPM)_(2)(Bi_(4)I_(16)·H_(2)O(1),has been prepared under solvothermal conditions.The centrosymmetric (Bi_(4)I_(16))^(4- ) tetraanion is constructed from four edge-shared slightly distorted BiI6 octahedrons.Due to the presence of larger conjugated system(isoquinoline ring),strongπ···πstacking interactions can be observed.Besides,strong I···I interactions can be monitored and extends the 0-D (Bi_(4)I_(16))^(4- )cluster to a quasi-1-D chain.The smaller energy gap of 2.13 eV is led by these non-covalent interactions.Its infrared emission might be caused by strong charge transfer between anions and cations.Furthermore,the reversible thermochromic behavior with low chromotropic temperature of 80℃can be observed,whose mechanism was discussed.
文摘Background:Potassium(K)deficiency has become a common field production problem following the widespread adoption of Bacillus thuringiensis(Bt)transgenic cotton(Gossypium hirsutum L.)worldwide.The purpose of this study was to clarify whether the introduction of Bt gene directly reduces the K-use efficiency of cotton to induce K deficiency.Results:The cotton variety,Jihe 321(wild type,WT)and its two Bt(Cry1Ac)-transgenic overexpression lines(OE-29317,OE-29312)were studied in field with low soil-test K+(47.8 mg·kg^(−1)).In the field with low soil-test K+,only OE-29317 had less biomass and K+accumulation than the WT at some growth stages.Both Bt lines produced similar or even greater seed cotton yield than WT in the field.When the Bt gene(~70%)in OE-29317 and OE-29312 plants was silenced by virus-induced gene silencing(VIGS),the VIGS-Bt plants did not produce more biomass than VIGSgreen fluorescent protein(control)plants.Conclusions:The introduction of Bt gene did not necessarily hinder the K use efficiency of the cotton lines under this study.
基金Supported by National Natural Science Foundation of China
文摘Palladium-catalyzed coupling of trifluorovinylzinc reagent with substituted aryl halides Y-C_6H_4-X (Y=p-NO_2, p-and m-COOMe, p-COOH, p-CONH_2, p- and m-CN; X=Br, I, Cl) provides a synthetic method for α, β, β-trifluorostyrenes(Y-TFS's). A series of previously unavailable Y-TFS's were thus obtained.
文摘BACKGROUND Lung cancer is increasing in incidence worldwide,and targeted therapies are developing at a rapid pace.Furthermore,the KRAS specific gene is strongly associated with non-small cell lung cancer(NSCLC).Adult patients with locally advanced or metastatic NSCLC who have tested positive for the KRAS G12C mutation and have progressed after at least one systemic treatment are treated with sotorasib.CASE SUMMARY In this study,we report on an advanced NSCLC with a KRAS G12C mutation.The histological diagnosis indicates stage IVB left lung adenocarcinoma with pelvic and bone metastases,identified as cT4N2bM1c.Using circulating tumor DNA analysis,it was possible to determine the mutation abundance of the KRAS gene exon 2,c.34G>Tp.G12C,which was 32.3%.The patient was advised to take sotorasib as part of their treatment.The imaging data were compared before and after treatment.Furthermore,clinical reassessments and regular serial blood testing were conducted.We found that the patient’s clinical symptoms significantly improved after receiving sotorasib medication,and there were no notable side effects,such as liver toxicity,during the treatment.CONCLUSION Sotorasib has shown promising clinical efficacy in patients with the KRAS G12c mutation and has no apparent toxic side effects.
文摘Purpose:Digitoxin is a cardiac glycoside used in the treatment of heart failure.Inspired by its known antiinflammatory effect,this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury(ALI).Method:28 wistar albino rats were divided into 4 groups.Sepsis model is performed by the feces intraperitoneal-injection procedure(FIP).Results:TNF-a,CRP,IL-6,IL 1-Beta,lactic acid,and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group.When the same groups were examined,histological improvements such as decrease in alveolar inflammation and decrease in septal thickening in the digitoxin group and thorax CT were found to be significantly higher in the Hounsfield unit digitoxin group compared to the Saline group.Conclusion:Digitoxin has shown biochemical improvement in sepsis with all known mechanisms of action,and healing effects in both computerized tomography and histology in the lung.
文摘The optically active R-4-phenyl-2-hydroxy butyrates were prepared by esterification of the racemic acid or transesterification of the racemic ester catalyzed by lipase from Candida cyclindra (CCL) in organic media.
文摘Polyfluoroalkylated biphenyl was obtained from reaction of benzene with R_FI/Na_2S_2O_4 using cetyltrimethylammonium bromide (CTAB) as PTC followed by dehydrogenation with DDQ in 38-43% yield.
文摘During COVID-19,the repercussions on scholar dynamics,functioning and structure were inevitable,causing an impact on groups that,historically,are minority in relation to the scope of school inclusion policies,such as students diagnosed with autism spectrum disorder(ASD).This scenario is followed by educational phenomena in the face of which School Psychology has collaborated with the advancement of research and knowledge production.This qualitative study,based on Historical-Cultural Psychology and Critical School Psychology,analyzed the role of the school psychologist in monitoring students diagnosed with ASD in the context of regular school during the pandemic.The following procedures were conducted:application of an online questionnaire;and semi-structured interviews with four school psychologists.As a result,three zones of shared meanings were built:the claim for the right to education with support and adaptations;the psychologist as the great savior of inclusion;the non-total inclusion that denounces the structure of injustice by school.The information suggests that professional performance was hampered by different obstacles in the pandemic,such as the difficulty imposed by school,overload of demands,and impasses in the implementation of inclusion historically experienced at school,revealing that the school structure still carries historical consequences of exclusion.These shared meanings have demanded a professional performance with more effort,resistance,and strategies that accept the demands of school inclusion,providing collective mobilization,together with school actors,capable of breaking down barriers,especially those related to capacitist concepts.
文摘Perfluoroalkylbenzo crown ethers were readily prepared from the reaction of benzo crown ethers with sodium perfluoroalkanesulfinates in the presence of an oxidizing agent such as Ce(SO_4)_2 or Mn(OAC)_3.2H_2O in good yields through a radical process.
基金Innovation Project of Outstanding Talents Training of West Anhui College(Project Number:WXXY2020002)Anhui Province Demonstration Grassroots Teaching Organization Project(Project Number:2020SJSFJX22403)+2 种基金Curriculum Ideological and Political Construction Research Project of Anhui Province(Project Number:2020KCSZYJXM253)Ideological and Political Demonstration Course of Anhui Province(Project Number:2020SZSFKC0940)Ideological and Political Demonstration Course of Anhui Province(Project Number:2020SZSFKC0907)。
文摘Taking college mathematics as an example,a questionnaire was designed for college mathematics teachers and students to fully comprehend the teaching situation.This paper mainly discusses the problems existing in the teaching of college mathematics and proposes the strategy of integrating PBL with curriculum ideological and political elements in college mathematics,so as to change the teaching process and improve the teaching quality.
