Fish constitutes the main protein source for the Amazonian population.However,the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regi...Fish constitutes the main protein source for the Amazonian population.However,the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regional scale remain largely unexplored.Here we assessed exposure levels of 10 trace elements andmetals(Cr,Mn,Fe,Ni,Cu,Zn,As,Cd,Pb,and Hg)in 56 samples belonging to 11 different species of fish from the Brazilian Amazon.We studied the relationship between exposure levels,fish origin,and fish feeding habits,and assessed toxicological and carcinogenic risks for the Amazonian population.No significant correlation was found between sampling site and exposure levels to the studied elements,but a significant difference was found between the accumulation of some metals and the position of the fish species in the food chain.The concentrations of Cr and Hg in fish flesh were found to exceed the Brazilian limits for human consumption.This study shows that current fish consumption patterns can lead to estimated daily intakes of Hg,As and Cr that exceed the oral reference dose,thus posing a toxicological concern.Furthermore,carcinogenic risks may be expected due to the continued exposure to Cr and As.The results of this study show that the consumption of wild caught fish in the Amazon region should be controlled.Moreover,continued monitoring of trace element and metal contamination in fish and on the health of the Amazonian population is recommended,particularly for riverine and indigenous communities.展开更多
BACKGROUND Toll-like receptors(TLRs)are the first line of host defense,and are involved in Helicobacter pylori(H.pylori)recognition and activation of both inflammatory and carcinogenic processes.The presence of single...BACKGROUND Toll-like receptors(TLRs)are the first line of host defense,and are involved in Helicobacter pylori(H.pylori)recognition and activation of both inflammatory and carcinogenic processes.The presence of single nucleotide polymorphisms(SNPs)in genes that activate the immune response may modulate the risk of precancerous lesions and gastric cancer(GC).Among them,Toll-like receptor 9(TLR9)polymorphisms have emerged with a risk factor of infectious diseases and cancer,however the studies are still inconclusive.AIM To evaluate whether TLR9 rs5743836 and rs187084 SNPs contribute to the risk of gastric carcinogenesis,and its influence on mRNA expression.METHODS A case-control study was conducted to evaluate two TLR9 SNPs(TLR9-1237 TCrs5743836 and TLR9-1486 CT-rs187084)in chronic gastritis(CG)and GC patients.A total of 609 DNA samples of peripheral blood[248 CG,161 GC,and 200 samples from healthy individuals(C)]were genotyped by polymerase chain reaction-restriction fragment length polymorphism.All samples were tested for the H.pylori infection using Hpx1 and Hpx2 primers.Quantitative polymerase chain reaction by TaqMan?assay was used to quantify TLR9 mRNA from fresh gastric tissues(48 GC,26 CG,and 14 C).RESULTS For TLR9-1237,the TC+CC or CC genotypes were associated with a higher risk of GC than C[recessive model odds ratio(OR)=5.01,95%confidence interval(CI):2.52-9.94,P<0.0001],and the CG(recessive model OR=4.63;95%CI:2.44-8.79,P<0.0001)groups.For TLR9-1486,an association between the CT+TT genotypes and increased risk of both GC(dominant model OR=2.72,95%CI:1.57-4.72,P<0.0001)and CG(dominant model OR=1.79,95%CI:1.15-2.79,P=0.0094)was observed when compared to the C group.Moreover,the presence of TLR9-1237 TC/CC+TLR9-1486 CC genotypes potentiate the risk for this neoplasm(OR=18.57;95%CI:5.06-68.15,P<0.0001).The TLR9 mRNA level was significantly higher in the GC group(RQ=9.24,P<0.0001)in relation to the CG group(RQ=1.55,P=0.0010)and normal mucosa(RQ=1.0).When the samples were grouped according to the polymorphic genotypes and the presence of H.pylori infection,an influence of TLR9-1237 TC+CC polymorphic genotypes(P=0.0083)and H.pylori infection(P<0.0001)was observed on the upregulation of mRNA expression.CONCLUSION Our findings show that TLR9 rs5743836 and rs187084 polymorphisms are associated with a higher risk of carcinogenesis gastric,and that TLR9 mRNA levels can be modulated by TLR9-1237 TC+CC variant genotypes and H.pylori infection.展开更多
Fast and unequivocal methods of questioned document analysis are essential in forensic science. Here, a desorption/ionization technique, EASI-MS, was assessed for its ability to investigate questioned driver’s licens...Fast and unequivocal methods of questioned document analysis are essential in forensic science. Here, a desorption/ionization technique, EASI-MS, was assessed for its ability to investigate questioned driver’s licenses (DL). Two suspects DL, displaying the same personal data in the proper fields (name and ID numbers), but with different individual photos, showing similar impressions on microscopic analysis, and authentic standards documents specimens were used as test cases. Profiles from authentic DL surface were dominated by a set of few minor ions, mainly from the plasticizers bis(2-ethylhexyl)phthalate and dibutylphthalate. The seized suspect counterfeit DL on points from personal data and photo were, however, dominated by abundant diagnostic ions of m/z 463, 507, 551, 595, 639, 683, which confirmed counterfeiting. Surfynol<sup>®</sup> and Nonoxynol-9<sup>®</sup>, which are common constituents of inkjet printing, were detected in the counterfeiting areas by high-accuracy EASI(+)-FT-ICR MS. The EASI-MS technique is shown therefore to offer an attractive tool for forensic investigation of questioned documents.展开更多
Objective: Understanding the perception of women who have recently given birth in a Brazilian hospital regarding labor pain and nursing involvement in the labor process. Methodology: exploratory, descriptive and quali...Objective: Understanding the perception of women who have recently given birth in a Brazilian hospital regarding labor pain and nursing involvement in the labor process. Methodology: exploratory, descriptive and qualitative study carried out in a Maternity part of the supplementary health system in the Federal District (DF). Data were collected between May and July 2015 through interviews using a semi-structured questionnaire. The sample consisted of 16 mothers and data analysis followed Bardin methodology in three phases. Results: The pain experienced during labor is surrounded by feelings and expectations. Both positive and negative feelings experienced by mothers were identified in the interviews and unanimous opinion was the fact that the second stage is the most painful period as continuous pain is experienced. Some of the participants compared pain with strong menstrual cramps, renal colic and back pain;others, said labor pain was the strongest ever experienced. The immediate contact with the newborn was referred to as a reward for coping with breast pain and suffering. Other factors such as the importance of follow-up, support and coping with the pain and care provided by health staff were also highlighted. Conclusion: empowerment of the mother and family through knowledge is considered an important tool to fight pain and cope with the birth process in a positive and physiological way, which in the long run promotes a cultural change in the population regarding the importance of vaginal birth.展开更多
Civil construction has high demand for new procedures and technologies capable of generating better results in numerous situations throughout the process.Nowadays,cavities in urban areas are commonly used due to the i...Civil construction has high demand for new procedures and technologies capable of generating better results in numerous situations throughout the process.Nowadays,cavities in urban areas are commonly used due to the implantation of commercial and residential developments with more than two floors,seeking a better use of the nobler areas of the big cities.In geotechnical terms,the filling of these cavities,with the local soil,especially in the Federal District,lateritic soils,can represent additional efforts for the structures and foundations and lead to a compromise of the technical and functional performance of the same,compromising the efficiency and the economy of the enterprise.In this sense,this research evaluates the mechanical behavior of the mixtures,using GEO5 Software,Containment Design and Verification Modules,presenting an alternative to fill cavities in urban regions,with a mixture of material with lower specific density in relation to the soil Natural.Proctor Normal compression tests,simple direct shear saturation and sample expansibility were performed.The results showed a reduction of 38%in the strength of the reinforced concrete curtain,as well as a 25%reduction in maximum bending moments and 31%in maximum shear forces,and a reduction of about 32%in the displacements of the structure to the soil with addition of expanded vermiculite for tests obtained in the saturated condition.For the compositions of cement soil,expanded vermiculite soil and soil cement and expanded vermiculite,the deformations were of the order of 0.3%,0.4%and 0.2%,respectively.展开更多
Building performance simulation (BPS) is a crucial tool towards the design of projects better adapted its climatic context. In this sense, the objective of this research is to evaluate a method of thermal comfort anal...Building performance simulation (BPS) is a crucial tool towards the design of projects better adapted its climatic context. In this sense, the objective of this research is to evaluate a method of thermal comfort analysis of schools in three Brazilian cities using BPS. The methodological procedures involved a literature review, in which the simulation tool and analysis method were chosen. Following simulations with the software DesignBuilder were performed using as study case a standard school typology designed by the General Coordination of Educational Infrastructure (CODIN/FNDE). This article evaluates its percentage occupied comfort hours in 3 reference cities: Cuiabá-MT, Brasília-DF, and Curitiba-PR. The results show respectively, for the cities of Curitiba, Brasília and Cuiabá, percentages of comfort hours of 76%, 70%, and 23%. The research states that the project must have different strategies for different climates. Finally, this article recommends this method should be applied to other cities and buildings.展开更多
<div style="text-align:justify;"> <span style="font-family:Verdana;"><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a chronic systemic rheumatic disease which i...<div style="text-align:justify;"> <span style="font-family:Verdana;"><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a chronic systemic rheumatic disease which is usually treated with corticosteroids and immunobiologicals. The goal of this article is to carry out an assessment of disease activity indices in a cohort of patients with rheumatoid arthritis. <strong>Patients and Methods:</strong> This is a prospective cohort study. Individuals from the Initial Rheumatoid Arthritis Brasília Cohort, which is an incident cohort of early RA diagnosed patients, were monitored at the Rheumatology Service of the Hospital Universitário de Brasília (HUB), University of Brasília (UnB), Brazil. A cross-sectional analysis was carried out from 2017 to 2018 to evaluate patients with 15 or more years of follow-up, through a direct interview and review of medical records. The main focus of the study is on the assessment of disease activity, based on the indices: 28-joint Disease Activity Score based on Creactive protein (DAS 28 CPR) and based on erythrocyte sedimentation rate (DAS 28 ESR), Clinical Disease Activity Index (CDAI), and Simple Disease Activity Index (SDAI). The reference remission criteria used were the Composite Disease Activity Indices. <strong>Results: </strong>107 patients were evaluated, mostly women, mean age of 55.1 years. Concerning the disease characteristics, 75.5% of the patients were positive for rheumatoid factor and 12 (11.3%) had documented erosive disease. The mean Health Assessment Questionnaire (HAQ) at the time of assessment was 0.6 (median 0.35). The indices analyzed showed: DAS28-ESR 48.6% of patients were in remission and 12.1% had low activity levels, DAS28-CRP 55.1% and 11.2%, SDAI 42% and 26.1%, CDAI 41.1% and 27.1%. These remission and low disease activity levels are higher than those generally found in the literature. <strong>Conclusion:</strong> This study presents a cohort of patients with RA who started treatment at an early stage of the disease and who achieved higher rates of remission and lower disease activity than those reported in the literature.</span> </div>展开更多
A 10 ha deciduous seasonal forest fragment (15°45'54''S and 49°04'03''W) found in the bioregion of the Savanna Eco Museum localized in the state of Goiás, Brazil was studied. For...A 10 ha deciduous seasonal forest fragment (15°45'54''S and 49°04'03''W) found in the bioregion of the Savanna Eco Museum localized in the state of Goiás, Brazil was studied. For the phytosociological survey, 10 sample plots of 20 × 20 m were systematically located. All living trees of 5 cm DBH and above were measured with the plot boundaries. There were 742 individuals belonging to 83 species and 38 families. The richest families in terms of the number of species were Leguminosae, Rubiaceae, Myrtaceae, Apocynaceae and Chrisobalanaceae, which contributed 48% of the total species. The species with the highest importance value indices (IVI) were Tapira quianensis (Aubl.), Protium heptaphyllum (Aubl.) March., Callisthene mayor (Mart.), Amaioua guianensis (Aubl.) and Anadenanthera macrocarpa (Benth.) Brenan. The Shannon diversity index was 3.80 nats/individuals and the Pielou equality index was 0.86 for the total population. 549 sampled trees had DBH values lower than 30 cm. This indicates that this forest has a high potential for natural succession. Two DBH distributions were observed: the typical reverse “J”, described frequently in the literature, and a nearly Gaussian distribution.展开更多
This work aimed to demonstrate if exists a relation between eutrophic processes of soil (N, P, K, pH, and organic matter) with phytosociology mosaic of native tree species in Brazilian adjacent sanitary landfill areas...This work aimed to demonstrate if exists a relation between eutrophic processes of soil (N, P, K, pH, and organic matter) with phytosociology mosaic of native tree species in Brazilian adjacent sanitary landfill areas of the savanna. One of the study area is located in Brasilia, Federal District, and the other one in Goiania, State of Goiás, 210 km far each other. The methodology consisted in techniques, procedures and specific software applied to this kind of data. There were used plots and subplots for each area and for the vegetation and soil survey. Statistical significance showed that there exists a relationship between eutrophic processes of soil with phytosociology mosaic of native savanna tree species.展开更多
Food production remains one of the main challenges for humankind in this century, and Brazil is one of the largest food-producing countries that have yet some land for economically or technically profitable farming ex...Food production remains one of the main challenges for humankind in this century, and Brazil is one of the largest food-producing countries that have yet some land for economically or technically profitable farming expansion. Moreover, knowing which areas constitute the Brazilian agricultural frontier is crucial for improving public policies and logistics infrastructure decisions. Data from the Brazilian Institute of Geography and Statistics from 1995 to 2019 were used in this study. We aimed to map and measure the expansion of agricultural areas in Brazil from 1995 to 2019 for temporary crops according to their mesoregions. We used a four-stage methodology, compared the results of two agglomerative clustering methods, and identified similar mesoregions based on their share trends in the Brazilian agricultural seeded area. Some mesoregions had higher positive trend values for their share of the Brazilian agricultural seeded area: Mato-grossense North (MT), Mato-grossense Northeast (MT), Mato Grosso do Sul Southwest (MS), Goiano South (GO), Extreme West Bahia (BA), Maranhense South (MA), Piauiense Southwest (PI), and Tocantins Eastern (TO). As a second leading group, the Paranaíba Upstream (MG), São José do Rio Preto (SP), Mato-grossense Southeast (MT), and Goiano East (GO), must be emphasized. Further research is recommended, including extending the study to permanent crops and applying top-down analysis targeting microregions or municipalities in the identified mesoregions.展开更多
<span style="font-family:Verdana;">The Lipid Accumulation Product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovasc...<span style="font-family:Verdana;">The Lipid Accumulation Product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovascular risk and mortality. The aim of this study was to verify the association of LAP with anthropometric, biochemical, visceral adiposity index and IR in adults and the elderly. This single cross-section center clinical study, with experimental, analytical, primary, and observational design, included 210 participants. Anthropometric (Body Mass Index (BMI), Waist Circumference (WC), and Neck Circumference (NC)), LAP, Visceral Adipose Index (VAI), and biochemical parameters (fasting glycemia, insulinemia (to calculate the Homa-IR index), total cholesterol, LDL-c, HDL-c, and triglycerides) were evaluated. The results showed that by separating the sample into three groups (adequate BMI and WC, adequate BMI and elevated WC, and elevated BMI and WC), the group with high BMI and WC showed a high value of LAP and VAI compared to the other groups, with a significant difference. Still, the data show a positive and significant correlation when relating the LAP with VAI, HOMA-IR, BMI, WC, NC, total cholesterol, triglycerides, and Diastolic Blood Pressure. It also showed an inversely proportional relationship when associating LAP with HDL-c (p < 0.0001). Thus, we show that LAP is closely related to visceral adiposity, IR, altered lipid parameters, and blood pressure, especially diastolic in the patients included in our study. For these reasons, we suggest that LAP is a reliable indicator of promising visceral adiposity for early detection of cardiovascular risk in the adult and senior population.</span>展开更多
BACKGROUND This was an observational, descriptive, and retrospective study from 2011 to 2020 from the Department of Informatics of the Brazilian Healthcare System database.AIM To describe the intestinal complications(...BACKGROUND This was an observational, descriptive, and retrospective study from 2011 to 2020 from the Department of Informatics of the Brazilian Healthcare System database.AIM To describe the intestinal complications(IC) of patients with ulcerative colitis(UC) who started conventional therapies in Brazil’s public Healthcare system.METHODS Patients ≥ 18 years of age who had at least one claim related to UC 10th revision of the International Statistical Classification of Diseases and Related Health Problems(ICD-10) code and at least 2 claims for conventional therapies were included. IC was defined as at least one claim of: UC-related hospitalization, procedures code for rectum or intestinal surgeries, and/or associated disease defined by ICD-10 codes(malignant neoplasia of colon, stenosis, hemorrhage, ulcer and other rectum or anus disease, megacolon, functional diarrhea volvulus, intussusception and erythema nodosum). Descriptive statistics, annual incidence, and incidence rate(IR) [per 100 patient-years(PY)] over the available follow-up period were calculated.RESULTS In total, 41229 UC patients were included(median age, 48 years;65% women) and the median(interquartile range) follow-up period was 3.3(1.8-5.3) years. Conventional therapy used during follow-up period included: mesalazine(87%), sulfasalazine(15%), azathioprine(16%) or methotrexate(1%) with a median duration of 1.9(0.8-4.0) years. Overall IR of IC was 3.2 cases per 100 PY. Among the IC claims, 54% were related to associated diseases, 20% to procedures and 26% to hospitalizations. The overall annual incidence of IC was 2.9%, 2.6% and 2.5% in the first, second and third year after the first claim for therapy(index date), respectively. Over the first 3 years, the annual IR of UC-related hospitalizations ranged from 0.8% to 1.1%;associated diseases from 0.9% to 1.2%-in which anus or rectum disease, and malignant neoplasia of colon were the most frequently reported;and procedure events from 0.6% to 0.7%, being intestinal resection and polyp removal the most frequent ones.CONCLUSION Study shows that UC patients under conventional therapy seem to present progression of disease developing some IC, which may have a negative impact on patients and the burden on the health system.展开更多
The Paraiba do Sul(PSR)and Guandu Rivers(GR)water diversion system(120 km long)is located in the main industrial pole of Brazil and supplies drinking water for 9.4 million people in the metropolitan region of Rio de J...The Paraiba do Sul(PSR)and Guandu Rivers(GR)water diversion system(120 km long)is located in the main industrial pole of Brazil and supplies drinking water for 9.4 million people in the metropolitan region of Rio de Janeiro.This study aims to discern the trace metals dynamics in this complex aquatic system.We used a combined approach of geochemical tools such as geochemical partitioning,Zn isotopes signatures,and multivariate statistics.Zinc and Pb concentrations in Suspended Particulate Matter(SPM)and sediments were considerably higher in some sites.The sediment partition of As,Cr,and Cu revealed the residual fraction(F4)as the main fraction for these elements,indicating low mobility.Zinc and Pb were mostly associated with the exchangeable/carbonate(F1)and the reducible(F2)fractions,respectively,implying a higher susceptibility of these elements to being released from sediments.Zinc isotopic compositions of sediments and SPM fell in a binary mixing source process between lithogenic(δ^(66/64)Zn_(JMC)≈+0.30‰)and anthropogenic(δ^(66/64)Zn_(JMC)≈+0.15‰)end members.The lighterδ^(66/64)Zn_(JMC)values accompanied by high Zn concentrations in exchangeable/carbonate fraction(ZnF1)enable the tracking of Zn anthropogenic sources in the studied rivers.Overall,the results indicated that Hg,Pb,and Zn had a dominant anthropogenic origin linked to the industrial activities,while As,Cr,and Cu were mainly associated with lithogenic sources.This work demonstrates how integrating geochemical tools is valuable for assessing geochemical processes and mixing source effects in anthropized river watersheds.展开更多
The current context of global efforts in the pursuit of sustainable development can be characterized by the perception of the scientific-technological losses of ecosystems and ecosystem services and their consequences...The current context of global efforts in the pursuit of sustainable development can be characterized by the perception of the scientific-technological losses of ecosystems and ecosystem services and their consequences for the survival of humanity in the face of threats of imbalances in the basic conditions for survival such as food production, the environmental quality, natural control of pests and diseases, loses of biodiversity and climate changes. Some recent initiatives at global, regional and local level are pointed and some conceptual trends and deployment strategies advance towards the consolidation of the principles of sustainable development, despite several difficulties for effectively reaching its goals. The trend of gradual changes in the models of developing nations and in the patterns of production and consumption is portrayed objectively, seeking to correlate with principles of environmental economics and green economy, since Cecil Pigou and Stuart Mill principles to recent researches as Kenneth Boulding, Herman Daly, Nicholas Georgescu-Rogen, Franz Capra, Ignacy Sachs, Edgar Morin, beyond others. The ability of the United Nations and governments to intervene in neoliberal logic aiming wider benefit to society and the reduction of the negative effects of market distortions, as striking on the global stage, represents a true redemption of the principles advocated by Cecil Pigou, at the beginning of the last century, both for the global economy and for their effects on environmental and social conflicts, social exclusion resulting from the current economic systems which are not necessary new strategies, principles, or economic formulas, but decision making to tackle the market with seriousness to promote equity, social justice and environmental sustainability, without sacrificing progress and development, as evident in the current discussion of social inclusion and the convergence of individual and collective interests, so far in the development model based on increasing production and consumption, yet with little environmental responsibility.展开更多
Background: Amazonian riverside communities consume large quantities of freshwater fish, comparable to marine fish consumption of Inuit, Scandinavian and Japanese populations. Few studies have considered the relation ...Background: Amazonian riverside communities consume large quantities of freshwater fish, comparable to marine fish consumption of Inuit, Scandinavian and Japanese populations. Few studies have considered the relation of high freshwater fish consumption and intake of omega-3 fatty acids (FA). Objective: The objective of the present study was to determine the profile of the concentrations of plasma phospholipid FAs and its relation with freshwater fish intake in 12 riverside communities in the Tapajós River basin (State of Pará, Brazilian Amazon). Design: This cross-sectional study included 333 adults (15 - 86 years old). Fish meal frequency was determined using a 7-day interview-administered dietary recall questionnaire. Fish were categorized as piscivorous and non-piscivorous fish on trophic level. Plasma phospholipid FAs were measured by capillary gas-liquid chromatography. Results: Participants consumed 5 to 6 fish meals a week, with twice as many non-piscivorous fish than piscivorous fish (4.4 fish/week vs 2.2 fish/week, respectively). The omega-3 FA levels in plasma phospholipids were low (EPA + DHA = 31.21 mg/L;%EPA + DHA = 2.59%). Omega-3 FAs increased with frequency of fish intake, and particularly with piscivorous fish, controlling for sociodemographic, anthropometric and lifestyle characteristics. DHA levels were greater in women than in men. Conclusions: Omega-3 FA in this Amazonian population increased with fish consumption, but although they consumed freshwater fish almost daily, the concentrations of omega-3 FA were relatively low and comparable to fish-eater communities for which fish is not a dietary mainstay. It is possible that nutrients present in marine, but not in certain freshwater fish species, may facilitate absorption of omega-3 FA. Sex and/or gender differences must be taken into account when assessing the relationship between fish consumption and plasma phospholipid omega-3 FA levels.展开更多
Over the past three decades,there has been increasing interest in miniaturized percutaneous nephrolithotomy(mPCNL)techniques featuring smaller tracts as they offer potential solutions to mitigate complications associa...Over the past three decades,there has been increasing interest in miniaturized percutaneous nephrolithotomy(mPCNL)techniques featuring smaller tracts as they offer potential solutions to mitigate complications associated with standard PCNL(sPCNL).However,despite this growing acceptance and recognition of its benefits,unresolved controversies and acknowledged limitations continue to impede widespread adoption due to a lack of consensus on optimal perioperative management strategies and procedural tips and tricks.In response to these challenges,an international panel comprising experts from the International Alliance of Urolithiasis(IAU)took on the task of compiling an expert consensus document on mPCNL procedures aimed at providing urologists with a comprehensive clinical framework for practice.This endeavor involved conducting a systematic literature review to identify research gaps(RGs),which formed the foundation for developing a structured questionnaire survey.Subsequently,a two-round modified Delphi survey was implemented,culminating in a group meeting to generate final evidence-based comments.All 64 experts completed the second-round survey,resulting in a response rate of 100.0%.Fifty-eight key questions were raised focusing on mPCNLs within 4 main domains,including general information(13 questions),preoperative work-up(13 questions),procedural tips and tricks(19 questions),and postoperative evaluation and follow-up(13 questions).Additionally,9 questions evaluated the experts’experience with PCNLs.Consensus was reached on 30 questions after the second-round survey,while professional statements for the remaining 28 key questions were provided after discussion in an online panel meeting.mPCNL,characterized by a tract smaller than 18 Fr and an innovative lithotripsy technique,has firmly established itself as a viable and effective approach for managing upper urinary tract stones in both adults and pediatrics.It offers several advantages over sPCNL including reduced bleeding,fewer requirements for nephrostomy tubes,decreased pain,and shorter hospital stays.The series of detailed techniques presented here serve as a comprehensive guide for urologists,aiming to improve their procedural understanding and optimize patient outcomes.展开更多
Background Helminthiases are neglected diseases that affect billions of people worldwide,particularly those with inadequate sanitation,poor hygiene practices,and limited access to clean water.Due to frequent underrepo...Background Helminthiases are neglected diseases that affect billions of people worldwide,particularly those with inadequate sanitation,poor hygiene practices,and limited access to clean water.Due to frequent underreporting,wastewater-based epidemiology has emerged as a valuable tool for monitoring parasitic infections at populationlevel.This study aimed to detect and quantify helminth eggs in untreated sewage sludge from eight wastewater treatment plants located in different Brazilian socioeconomic regions.Methods The study was conducted from June 2021 to December 2023 in Goias and Federal District,the Brazilian federative unit with the highest income inequality.Samples were collected bimonthly(n=121).Helminth eggs were recovered using centrifugation and flotation with a ZnSO_(4) solution(d=1.30 g/ml).After 21–28 days of incubation in sulfuric acid,viable eggs were identified and counted using a Sedgewick-Rafter Chamber under an optical microscope.Statistical analyses included One-way analysis of variance(ANOVA)followed by Tukey’s multiple comparisons test to evaluate differences in helminth egg counts between low-,medium-and high-income regions.Results Twelve helminth genera were identified,revealing significant differences in prevalence and diversity across socioeconomic strata.Cestode eggs,particularly Hymenolepis spp.(44.28%),were the most prevalent overall.Trematode eggs were less frequent but exhibited greater taxonomic diversity.Sludge from low-income areas had the highest egg concentration[16.61±3.02 eggs per gram of dry mass(eggs/g DM)],nearly five times greater than in high-income areas such as Brasilia Norte(3.56±0.55 eggs/g DM;P=8.8×10^(-9)).Ascaris spp.(19.27%)and Trichuris spp.(7.90%)predominated in low-income areas.Medium-income regions showed intermediate values,with notable regional variation.Conclusions Our results demonstrate that helminth egg diversity and concentration in sewage sludge are closely related to the socioeconomic characteristics of the served population.These findings may inform prevention and control strategies in vulnerable areas and support the development of public health and sanitation policies that address social and environmental inequalities in Brazil’s Central-Western region.展开更多
Previous research has explored the potential to integrate lidar and optical data in aboveground biomass(AGB)estimation,but how different data sources,vegetation types,and modeling algorithms influence AGB estimation i...Previous research has explored the potential to integrate lidar and optical data in aboveground biomass(AGB)estimation,but how different data sources,vegetation types,and modeling algorithms influence AGB estimation is poorly understood.This research conducts a comparative analysis of different data sources and modeling approaches in improving AGB estimation.RapidEye-based spectral responses and textures,lidar-derived metrics,and their combination were used to develop AGB estimation models.The results indicated that(1)overall,RapidEye data are not suitable for AGB estimation,but when AGB falls within 50–150 Mg/ha,support vector regression based on stratification of vegetation types provided good AGB estimation;(2)Lidar data provided stable and better estimations than RapidEye data;and stratification of vegetation types cannot improve estimation;(3)The combination of lidar and RapidEye data cannot provide better performance than lidar data alone;(4)AGB ranges affect the selection of the best AGB models,and a combination of different estimation results from the best model for each AGB range can improve AGB estimation;(5)This research implies that an optimal procedure for AGB estimation for a specific study exists,depending on the careful selection of data sources,modeling algorithms,forest types,and AGB ranges.展开更多
Aims Different plant functional groups display diverging responses to the same environmental gradients.Here,we assess the effects of environmental and spatial predictors on species turnover of three functional groups ...Aims Different plant functional groups display diverging responses to the same environmental gradients.Here,we assess the effects of environmental and spatial predictors on species turnover of three functional groups of Brazilian savannas(Cerrado)plants—trees,palms and lianas—across the transition zone between the Cerrado and Amazon biomes in central Brazil.Methods We used edaphic,climatic and plant composition data from nine one-hectare plots to assess the effects of the environment and space on species turnover using a Redundancy Analysis and Generalized Dissimilarity Modeling(GDM),associated with variance partitioning.Important Findings We recorded 167 tree species,5 palms and 4 liana species.Environmental variation was most important in explaining species turnover,relative to geographic distance,but the best predictors differed between functional groups:geographic distance and silt for lianas;silt for palms;geographic distance,temperature and elevation for trees.Geographic distances alone exerted little influence over species turnover for the three functional groups.The pure environmental variation explained most of the liana and palm turnover,while tree turnover was largely explained by the shared spatial and environmental contribution.The effects of geographic distance upon species turnover leveled off at about 300 km for trees,and 200 km for lianas,whereas they were unimportant for palm species turnover.Our results indicate that environmental factors that determine floristic composition and species turnover differ substantially between plant functional groups in savannas.Therefore,we recommend that studies that aim to investigate the role of environmental conditions in determining plant species turnover should examine plant functional groups separately.展开更多
Depending on the magnitude and nature of a disaster,identifying the victims can be a complex task that requires coordinated work by disaster victim identification(DVI)teams based on pre-established protocols.Thus,the ...Depending on the magnitude and nature of a disaster,identifying the victims can be a complex task that requires coordinated work by disaster victim identification(DVI)teams based on pre-established protocols.Thus,the analysis of fingerprints has been presented as a method to establish,when possible,the identity of the victims during the DVI process.This study discusses the importance of this primary method of identification and the results obtained in four different disasters in which Brazilian DVI teams were involved:the Air France Flight AF447 plane crash in the Atlantic Ocean,floods and mudslides in the State of Rio de Janeiro,Brazil,the LaMia Flight 2933 plane crash in Colombia,and the tailings dam collapse in Brumadinho,Brazil.Here,we also report the use of the automatic fingerprint capture and identification system,called Alethia,developed by the Federal Police of Brazil and used in the victim identification process in the two latter events mentioned above.展开更多
基金supported by the National Geographic Society through an early career grant to A.Rico (EC-59809C-19)Support Programme-PlanGenT (CIDEGENT/2020/043)of the Generalitat ValencianaR.Oliveira acknowledges"Fundacao de Amparo a Pesquisa do Estado de Sao Paulo"-FAPESP (Project 2018/03108-0).
文摘Fish constitutes the main protein source for the Amazonian population.However,the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regional scale remain largely unexplored.Here we assessed exposure levels of 10 trace elements andmetals(Cr,Mn,Fe,Ni,Cu,Zn,As,Cd,Pb,and Hg)in 56 samples belonging to 11 different species of fish from the Brazilian Amazon.We studied the relationship between exposure levels,fish origin,and fish feeding habits,and assessed toxicological and carcinogenic risks for the Amazonian population.No significant correlation was found between sampling site and exposure levels to the studied elements,but a significant difference was found between the accumulation of some metals and the position of the fish species in the food chain.The concentrations of Cr and Hg in fish flesh were found to exceed the Brazilian limits for human consumption.This study shows that current fish consumption patterns can lead to estimated daily intakes of Hg,As and Cr that exceed the oral reference dose,thus posing a toxicological concern.Furthermore,carcinogenic risks may be expected due to the continued exposure to Cr and As.The results of this study show that the consumption of wild caught fish in the Amazon region should be controlled.Moreover,continued monitoring of trace element and metal contamination in fish and on the health of the Amazonian population is recommended,particularly for riverine and indigenous communities.
基金Supported by The Sao Paulo Research Foundation(FAPESP),NO.2013/14022-6 and NO.2014/17716-1
文摘BACKGROUND Toll-like receptors(TLRs)are the first line of host defense,and are involved in Helicobacter pylori(H.pylori)recognition and activation of both inflammatory and carcinogenic processes.The presence of single nucleotide polymorphisms(SNPs)in genes that activate the immune response may modulate the risk of precancerous lesions and gastric cancer(GC).Among them,Toll-like receptor 9(TLR9)polymorphisms have emerged with a risk factor of infectious diseases and cancer,however the studies are still inconclusive.AIM To evaluate whether TLR9 rs5743836 and rs187084 SNPs contribute to the risk of gastric carcinogenesis,and its influence on mRNA expression.METHODS A case-control study was conducted to evaluate two TLR9 SNPs(TLR9-1237 TCrs5743836 and TLR9-1486 CT-rs187084)in chronic gastritis(CG)and GC patients.A total of 609 DNA samples of peripheral blood[248 CG,161 GC,and 200 samples from healthy individuals(C)]were genotyped by polymerase chain reaction-restriction fragment length polymorphism.All samples were tested for the H.pylori infection using Hpx1 and Hpx2 primers.Quantitative polymerase chain reaction by TaqMan?assay was used to quantify TLR9 mRNA from fresh gastric tissues(48 GC,26 CG,and 14 C).RESULTS For TLR9-1237,the TC+CC or CC genotypes were associated with a higher risk of GC than C[recessive model odds ratio(OR)=5.01,95%confidence interval(CI):2.52-9.94,P<0.0001],and the CG(recessive model OR=4.63;95%CI:2.44-8.79,P<0.0001)groups.For TLR9-1486,an association between the CT+TT genotypes and increased risk of both GC(dominant model OR=2.72,95%CI:1.57-4.72,P<0.0001)and CG(dominant model OR=1.79,95%CI:1.15-2.79,P=0.0094)was observed when compared to the C group.Moreover,the presence of TLR9-1237 TC/CC+TLR9-1486 CC genotypes potentiate the risk for this neoplasm(OR=18.57;95%CI:5.06-68.15,P<0.0001).The TLR9 mRNA level was significantly higher in the GC group(RQ=9.24,P<0.0001)in relation to the CG group(RQ=1.55,P=0.0010)and normal mucosa(RQ=1.0).When the samples were grouped according to the polymorphic genotypes and the presence of H.pylori infection,an influence of TLR9-1237 TC+CC polymorphic genotypes(P=0.0083)and H.pylori infection(P<0.0001)was observed on the upregulation of mRNA expression.CONCLUSION Our findings show that TLR9 rs5743836 and rs187084 polymorphisms are associated with a higher risk of carcinogenesis gastric,and that TLR9 mRNA levels can be modulated by TLR9-1237 TC+CC variant genotypes and H.pylori infection.
文摘Fast and unequivocal methods of questioned document analysis are essential in forensic science. Here, a desorption/ionization technique, EASI-MS, was assessed for its ability to investigate questioned driver’s licenses (DL). Two suspects DL, displaying the same personal data in the proper fields (name and ID numbers), but with different individual photos, showing similar impressions on microscopic analysis, and authentic standards documents specimens were used as test cases. Profiles from authentic DL surface were dominated by a set of few minor ions, mainly from the plasticizers bis(2-ethylhexyl)phthalate and dibutylphthalate. The seized suspect counterfeit DL on points from personal data and photo were, however, dominated by abundant diagnostic ions of m/z 463, 507, 551, 595, 639, 683, which confirmed counterfeiting. Surfynol<sup>®</sup> and Nonoxynol-9<sup>®</sup>, which are common constituents of inkjet printing, were detected in the counterfeiting areas by high-accuracy EASI(+)-FT-ICR MS. The EASI-MS technique is shown therefore to offer an attractive tool for forensic investigation of questioned documents.
文摘Objective: Understanding the perception of women who have recently given birth in a Brazilian hospital regarding labor pain and nursing involvement in the labor process. Methodology: exploratory, descriptive and qualitative study carried out in a Maternity part of the supplementary health system in the Federal District (DF). Data were collected between May and July 2015 through interviews using a semi-structured questionnaire. The sample consisted of 16 mothers and data analysis followed Bardin methodology in three phases. Results: The pain experienced during labor is surrounded by feelings and expectations. Both positive and negative feelings experienced by mothers were identified in the interviews and unanimous opinion was the fact that the second stage is the most painful period as continuous pain is experienced. Some of the participants compared pain with strong menstrual cramps, renal colic and back pain;others, said labor pain was the strongest ever experienced. The immediate contact with the newborn was referred to as a reward for coping with breast pain and suffering. Other factors such as the importance of follow-up, support and coping with the pain and care provided by health staff were also highlighted. Conclusion: empowerment of the mother and family through knowledge is considered an important tool to fight pain and cope with the birth process in a positive and physiological way, which in the long run promotes a cultural change in the population regarding the importance of vaginal birth.
文摘Civil construction has high demand for new procedures and technologies capable of generating better results in numerous situations throughout the process.Nowadays,cavities in urban areas are commonly used due to the implantation of commercial and residential developments with more than two floors,seeking a better use of the nobler areas of the big cities.In geotechnical terms,the filling of these cavities,with the local soil,especially in the Federal District,lateritic soils,can represent additional efforts for the structures and foundations and lead to a compromise of the technical and functional performance of the same,compromising the efficiency and the economy of the enterprise.In this sense,this research evaluates the mechanical behavior of the mixtures,using GEO5 Software,Containment Design and Verification Modules,presenting an alternative to fill cavities in urban regions,with a mixture of material with lower specific density in relation to the soil Natural.Proctor Normal compression tests,simple direct shear saturation and sample expansibility were performed.The results showed a reduction of 38%in the strength of the reinforced concrete curtain,as well as a 25%reduction in maximum bending moments and 31%in maximum shear forces,and a reduction of about 32%in the displacements of the structure to the soil with addition of expanded vermiculite for tests obtained in the saturated condition.For the compositions of cement soil,expanded vermiculite soil and soil cement and expanded vermiculite,the deformations were of the order of 0.3%,0.4%and 0.2%,respectively.
基金The first author wishes thanks to the Brazilian National Council for Scientific and Technological Development(CNPq)for supporting this research.
文摘Building performance simulation (BPS) is a crucial tool towards the design of projects better adapted its climatic context. In this sense, the objective of this research is to evaluate a method of thermal comfort analysis of schools in three Brazilian cities using BPS. The methodological procedures involved a literature review, in which the simulation tool and analysis method were chosen. Following simulations with the software DesignBuilder were performed using as study case a standard school typology designed by the General Coordination of Educational Infrastructure (CODIN/FNDE). This article evaluates its percentage occupied comfort hours in 3 reference cities: Cuiabá-MT, Brasília-DF, and Curitiba-PR. The results show respectively, for the cities of Curitiba, Brasília and Cuiabá, percentages of comfort hours of 76%, 70%, and 23%. The research states that the project must have different strategies for different climates. Finally, this article recommends this method should be applied to other cities and buildings.
文摘<div style="text-align:justify;"> <span style="font-family:Verdana;"><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a chronic systemic rheumatic disease which is usually treated with corticosteroids and immunobiologicals. The goal of this article is to carry out an assessment of disease activity indices in a cohort of patients with rheumatoid arthritis. <strong>Patients and Methods:</strong> This is a prospective cohort study. Individuals from the Initial Rheumatoid Arthritis Brasília Cohort, which is an incident cohort of early RA diagnosed patients, were monitored at the Rheumatology Service of the Hospital Universitário de Brasília (HUB), University of Brasília (UnB), Brazil. A cross-sectional analysis was carried out from 2017 to 2018 to evaluate patients with 15 or more years of follow-up, through a direct interview and review of medical records. The main focus of the study is on the assessment of disease activity, based on the indices: 28-joint Disease Activity Score based on Creactive protein (DAS 28 CPR) and based on erythrocyte sedimentation rate (DAS 28 ESR), Clinical Disease Activity Index (CDAI), and Simple Disease Activity Index (SDAI). The reference remission criteria used were the Composite Disease Activity Indices. <strong>Results: </strong>107 patients were evaluated, mostly women, mean age of 55.1 years. Concerning the disease characteristics, 75.5% of the patients were positive for rheumatoid factor and 12 (11.3%) had documented erosive disease. The mean Health Assessment Questionnaire (HAQ) at the time of assessment was 0.6 (median 0.35). The indices analyzed showed: DAS28-ESR 48.6% of patients were in remission and 12.1% had low activity levels, DAS28-CRP 55.1% and 11.2%, SDAI 42% and 26.1%, CDAI 41.1% and 27.1%. These remission and low disease activity levels are higher than those generally found in the literature. <strong>Conclusion:</strong> This study presents a cohort of patients with RA who started treatment at an early stage of the disease and who achieved higher rates of remission and lower disease activity than those reported in the literature.</span> </div>
文摘A 10 ha deciduous seasonal forest fragment (15°45'54''S and 49°04'03''W) found in the bioregion of the Savanna Eco Museum localized in the state of Goiás, Brazil was studied. For the phytosociological survey, 10 sample plots of 20 × 20 m were systematically located. All living trees of 5 cm DBH and above were measured with the plot boundaries. There were 742 individuals belonging to 83 species and 38 families. The richest families in terms of the number of species were Leguminosae, Rubiaceae, Myrtaceae, Apocynaceae and Chrisobalanaceae, which contributed 48% of the total species. The species with the highest importance value indices (IVI) were Tapira quianensis (Aubl.), Protium heptaphyllum (Aubl.) March., Callisthene mayor (Mart.), Amaioua guianensis (Aubl.) and Anadenanthera macrocarpa (Benth.) Brenan. The Shannon diversity index was 3.80 nats/individuals and the Pielou equality index was 0.86 for the total population. 549 sampled trees had DBH values lower than 30 cm. This indicates that this forest has a high potential for natural succession. Two DBH distributions were observed: the typical reverse “J”, described frequently in the literature, and a nearly Gaussian distribution.
文摘This work aimed to demonstrate if exists a relation between eutrophic processes of soil (N, P, K, pH, and organic matter) with phytosociology mosaic of native tree species in Brazilian adjacent sanitary landfill areas of the savanna. One of the study area is located in Brasilia, Federal District, and the other one in Goiania, State of Goiás, 210 km far each other. The methodology consisted in techniques, procedures and specific software applied to this kind of data. There were used plots and subplots for each area and for the vegetation and soil survey. Statistical significance showed that there exists a relationship between eutrophic processes of soil with phytosociology mosaic of native savanna tree species.
文摘Food production remains one of the main challenges for humankind in this century, and Brazil is one of the largest food-producing countries that have yet some land for economically or technically profitable farming expansion. Moreover, knowing which areas constitute the Brazilian agricultural frontier is crucial for improving public policies and logistics infrastructure decisions. Data from the Brazilian Institute of Geography and Statistics from 1995 to 2019 were used in this study. We aimed to map and measure the expansion of agricultural areas in Brazil from 1995 to 2019 for temporary crops according to their mesoregions. We used a four-stage methodology, compared the results of two agglomerative clustering methods, and identified similar mesoregions based on their share trends in the Brazilian agricultural seeded area. Some mesoregions had higher positive trend values for their share of the Brazilian agricultural seeded area: Mato-grossense North (MT), Mato-grossense Northeast (MT), Mato Grosso do Sul Southwest (MS), Goiano South (GO), Extreme West Bahia (BA), Maranhense South (MA), Piauiense Southwest (PI), and Tocantins Eastern (TO). As a second leading group, the Paranaíba Upstream (MG), São José do Rio Preto (SP), Mato-grossense Southeast (MT), and Goiano East (GO), must be emphasized. Further research is recommended, including extending the study to permanent crops and applying top-down analysis targeting microregions or municipalities in the identified mesoregions.
文摘<span style="font-family:Verdana;">The Lipid Accumulation Product (LAP) is a clinical marker of visceral obesity and has been proposed as a simple, inexpensive, and accurate tool to estimate cardiovascular risk and mortality. The aim of this study was to verify the association of LAP with anthropometric, biochemical, visceral adiposity index and IR in adults and the elderly. This single cross-section center clinical study, with experimental, analytical, primary, and observational design, included 210 participants. Anthropometric (Body Mass Index (BMI), Waist Circumference (WC), and Neck Circumference (NC)), LAP, Visceral Adipose Index (VAI), and biochemical parameters (fasting glycemia, insulinemia (to calculate the Homa-IR index), total cholesterol, LDL-c, HDL-c, and triglycerides) were evaluated. The results showed that by separating the sample into three groups (adequate BMI and WC, adequate BMI and elevated WC, and elevated BMI and WC), the group with high BMI and WC showed a high value of LAP and VAI compared to the other groups, with a significant difference. Still, the data show a positive and significant correlation when relating the LAP with VAI, HOMA-IR, BMI, WC, NC, total cholesterol, triglycerides, and Diastolic Blood Pressure. It also showed an inversely proportional relationship when associating LAP with HDL-c (p < 0.0001). Thus, we show that LAP is closely related to visceral adiposity, IR, altered lipid parameters, and blood pressure, especially diastolic in the patients included in our study. For these reasons, we suggest that LAP is a reliable indicator of promising visceral adiposity for early detection of cardiovascular risk in the adult and senior population.</span>
文摘BACKGROUND This was an observational, descriptive, and retrospective study from 2011 to 2020 from the Department of Informatics of the Brazilian Healthcare System database.AIM To describe the intestinal complications(IC) of patients with ulcerative colitis(UC) who started conventional therapies in Brazil’s public Healthcare system.METHODS Patients ≥ 18 years of age who had at least one claim related to UC 10th revision of the International Statistical Classification of Diseases and Related Health Problems(ICD-10) code and at least 2 claims for conventional therapies were included. IC was defined as at least one claim of: UC-related hospitalization, procedures code for rectum or intestinal surgeries, and/or associated disease defined by ICD-10 codes(malignant neoplasia of colon, stenosis, hemorrhage, ulcer and other rectum or anus disease, megacolon, functional diarrhea volvulus, intussusception and erythema nodosum). Descriptive statistics, annual incidence, and incidence rate(IR) [per 100 patient-years(PY)] over the available follow-up period were calculated.RESULTS In total, 41229 UC patients were included(median age, 48 years;65% women) and the median(interquartile range) follow-up period was 3.3(1.8-5.3) years. Conventional therapy used during follow-up period included: mesalazine(87%), sulfasalazine(15%), azathioprine(16%) or methotrexate(1%) with a median duration of 1.9(0.8-4.0) years. Overall IR of IC was 3.2 cases per 100 PY. Among the IC claims, 54% were related to associated diseases, 20% to procedures and 26% to hospitalizations. The overall annual incidence of IC was 2.9%, 2.6% and 2.5% in the first, second and third year after the first claim for therapy(index date), respectively. Over the first 3 years, the annual IR of UC-related hospitalizations ranged from 0.8% to 1.1%;associated diseases from 0.9% to 1.2%-in which anus or rectum disease, and malignant neoplasia of colon were the most frequently reported;and procedure events from 0.6% to 0.7%, being intestinal resection and polyp removal the most frequent ones.CONCLUSION Study shows that UC patients under conventional therapy seem to present progression of disease developing some IC, which may have a negative impact on patients and the burden on the health system.
基金partly funded by the LMI-OCE and CNPq 400029/2015-4,420697/2018-7Jeremie Garnier was supported by CNPq grant 302722/2018-1。
文摘The Paraiba do Sul(PSR)and Guandu Rivers(GR)water diversion system(120 km long)is located in the main industrial pole of Brazil and supplies drinking water for 9.4 million people in the metropolitan region of Rio de Janeiro.This study aims to discern the trace metals dynamics in this complex aquatic system.We used a combined approach of geochemical tools such as geochemical partitioning,Zn isotopes signatures,and multivariate statistics.Zinc and Pb concentrations in Suspended Particulate Matter(SPM)and sediments were considerably higher in some sites.The sediment partition of As,Cr,and Cu revealed the residual fraction(F4)as the main fraction for these elements,indicating low mobility.Zinc and Pb were mostly associated with the exchangeable/carbonate(F1)and the reducible(F2)fractions,respectively,implying a higher susceptibility of these elements to being released from sediments.Zinc isotopic compositions of sediments and SPM fell in a binary mixing source process between lithogenic(δ^(66/64)Zn_(JMC)≈+0.30‰)and anthropogenic(δ^(66/64)Zn_(JMC)≈+0.15‰)end members.The lighterδ^(66/64)Zn_(JMC)values accompanied by high Zn concentrations in exchangeable/carbonate fraction(ZnF1)enable the tracking of Zn anthropogenic sources in the studied rivers.Overall,the results indicated that Hg,Pb,and Zn had a dominant anthropogenic origin linked to the industrial activities,while As,Cr,and Cu were mainly associated with lithogenic sources.This work demonstrates how integrating geochemical tools is valuable for assessing geochemical processes and mixing source effects in anthropized river watersheds.
文摘The current context of global efforts in the pursuit of sustainable development can be characterized by the perception of the scientific-technological losses of ecosystems and ecosystem services and their consequences for the survival of humanity in the face of threats of imbalances in the basic conditions for survival such as food production, the environmental quality, natural control of pests and diseases, loses of biodiversity and climate changes. Some recent initiatives at global, regional and local level are pointed and some conceptual trends and deployment strategies advance towards the consolidation of the principles of sustainable development, despite several difficulties for effectively reaching its goals. The trend of gradual changes in the models of developing nations and in the patterns of production and consumption is portrayed objectively, seeking to correlate with principles of environmental economics and green economy, since Cecil Pigou and Stuart Mill principles to recent researches as Kenneth Boulding, Herman Daly, Nicholas Georgescu-Rogen, Franz Capra, Ignacy Sachs, Edgar Morin, beyond others. The ability of the United Nations and governments to intervene in neoliberal logic aiming wider benefit to society and the reduction of the negative effects of market distortions, as striking on the global stage, represents a true redemption of the principles advocated by Cecil Pigou, at the beginning of the last century, both for the global economy and for their effects on environmental and social conflicts, social exclusion resulting from the current economic systems which are not necessary new strategies, principles, or economic formulas, but decision making to tackle the market with seriousness to promote equity, social justice and environmental sustainability, without sacrificing progress and development, as evident in the current discussion of social inclusion and the convergence of individual and collective interests, so far in the development model based on increasing production and consumption, yet with little environmental responsibility.
文摘Background: Amazonian riverside communities consume large quantities of freshwater fish, comparable to marine fish consumption of Inuit, Scandinavian and Japanese populations. Few studies have considered the relation of high freshwater fish consumption and intake of omega-3 fatty acids (FA). Objective: The objective of the present study was to determine the profile of the concentrations of plasma phospholipid FAs and its relation with freshwater fish intake in 12 riverside communities in the Tapajós River basin (State of Pará, Brazilian Amazon). Design: This cross-sectional study included 333 adults (15 - 86 years old). Fish meal frequency was determined using a 7-day interview-administered dietary recall questionnaire. Fish were categorized as piscivorous and non-piscivorous fish on trophic level. Plasma phospholipid FAs were measured by capillary gas-liquid chromatography. Results: Participants consumed 5 to 6 fish meals a week, with twice as many non-piscivorous fish than piscivorous fish (4.4 fish/week vs 2.2 fish/week, respectively). The omega-3 FA levels in plasma phospholipids were low (EPA + DHA = 31.21 mg/L;%EPA + DHA = 2.59%). Omega-3 FAs increased with frequency of fish intake, and particularly with piscivorous fish, controlling for sociodemographic, anthropometric and lifestyle characteristics. DHA levels were greater in women than in men. Conclusions: Omega-3 FA in this Amazonian population increased with fish consumption, but although they consumed freshwater fish almost daily, the concentrations of omega-3 FA were relatively low and comparable to fish-eater communities for which fish is not a dietary mainstay. It is possible that nutrients present in marine, but not in certain freshwater fish species, may facilitate absorption of omega-3 FA. Sex and/or gender differences must be taken into account when assessing the relationship between fish consumption and plasma phospholipid omega-3 FA levels.
文摘Over the past three decades,there has been increasing interest in miniaturized percutaneous nephrolithotomy(mPCNL)techniques featuring smaller tracts as they offer potential solutions to mitigate complications associated with standard PCNL(sPCNL).However,despite this growing acceptance and recognition of its benefits,unresolved controversies and acknowledged limitations continue to impede widespread adoption due to a lack of consensus on optimal perioperative management strategies and procedural tips and tricks.In response to these challenges,an international panel comprising experts from the International Alliance of Urolithiasis(IAU)took on the task of compiling an expert consensus document on mPCNL procedures aimed at providing urologists with a comprehensive clinical framework for practice.This endeavor involved conducting a systematic literature review to identify research gaps(RGs),which formed the foundation for developing a structured questionnaire survey.Subsequently,a two-round modified Delphi survey was implemented,culminating in a group meeting to generate final evidence-based comments.All 64 experts completed the second-round survey,resulting in a response rate of 100.0%.Fifty-eight key questions were raised focusing on mPCNLs within 4 main domains,including general information(13 questions),preoperative work-up(13 questions),procedural tips and tricks(19 questions),and postoperative evaluation and follow-up(13 questions).Additionally,9 questions evaluated the experts’experience with PCNLs.Consensus was reached on 30 questions after the second-round survey,while professional statements for the remaining 28 key questions were provided after discussion in an online panel meeting.mPCNL,characterized by a tract smaller than 18 Fr and an innovative lithotripsy technique,has firmly established itself as a viable and effective approach for managing upper urinary tract stones in both adults and pediatrics.It offers several advantages over sPCNL including reduced bleeding,fewer requirements for nephrostomy tubes,decreased pain,and shorter hospital stays.The series of detailed techniques presented here serve as a comprehensive guide for urologists,aiming to improve their procedural understanding and optimize patient outcomes.
基金financial support from the Fundacao de Amparo a Pesquisa do Distrito Federal(FAPDF,grant 00193–00002136/2023–01)from the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior–Brasil(CAPES-COFECUB,grant 88881.711954/2022–01)from CNPq(grant 316892/2023–8).
文摘Background Helminthiases are neglected diseases that affect billions of people worldwide,particularly those with inadequate sanitation,poor hygiene practices,and limited access to clean water.Due to frequent underreporting,wastewater-based epidemiology has emerged as a valuable tool for monitoring parasitic infections at populationlevel.This study aimed to detect and quantify helminth eggs in untreated sewage sludge from eight wastewater treatment plants located in different Brazilian socioeconomic regions.Methods The study was conducted from June 2021 to December 2023 in Goias and Federal District,the Brazilian federative unit with the highest income inequality.Samples were collected bimonthly(n=121).Helminth eggs were recovered using centrifugation and flotation with a ZnSO_(4) solution(d=1.30 g/ml).After 21–28 days of incubation in sulfuric acid,viable eggs were identified and counted using a Sedgewick-Rafter Chamber under an optical microscope.Statistical analyses included One-way analysis of variance(ANOVA)followed by Tukey’s multiple comparisons test to evaluate differences in helminth egg counts between low-,medium-and high-income regions.Results Twelve helminth genera were identified,revealing significant differences in prevalence and diversity across socioeconomic strata.Cestode eggs,particularly Hymenolepis spp.(44.28%),were the most prevalent overall.Trematode eggs were less frequent but exhibited greater taxonomic diversity.Sludge from low-income areas had the highest egg concentration[16.61±3.02 eggs per gram of dry mass(eggs/g DM)],nearly five times greater than in high-income areas such as Brasilia Norte(3.56±0.55 eggs/g DM;P=8.8×10^(-9)).Ascaris spp.(19.27%)and Trichuris spp.(7.90%)predominated in low-income areas.Medium-income regions showed intermediate values,with notable regional variation.Conclusions Our results demonstrate that helminth egg diversity and concentration in sewage sludge are closely related to the socioeconomic characteristics of the served population.These findings may inform prevention and control strategies in vulnerable areas and support the development of public health and sanitation policies that address social and environmental inequalities in Brazil’s Central-Western region.
基金supported by the National Natural Science Foundation of China(No#41571411)the Zhejiang A&F University’s Research and Development Fund for the talent startup project(No#2013FR052)+1 种基金Keller,dos-Santos,Bolfe,and Batistella acknowledge the support from the Brazilian National Council for Scientific and Tech-nological Development–CNPq(No#457927/2013-5)Data were acquired by the Sustainable Landscapes Brazil project supported by the Brazilian Agricultural Research Corporation(EMBRAPA),the US Forest Service,the USAID,and the US Department of State.
文摘Previous research has explored the potential to integrate lidar and optical data in aboveground biomass(AGB)estimation,but how different data sources,vegetation types,and modeling algorithms influence AGB estimation is poorly understood.This research conducts a comparative analysis of different data sources and modeling approaches in improving AGB estimation.RapidEye-based spectral responses and textures,lidar-derived metrics,and their combination were used to develop AGB estimation models.The results indicated that(1)overall,RapidEye data are not suitable for AGB estimation,but when AGB falls within 50–150 Mg/ha,support vector regression based on stratification of vegetation types provided good AGB estimation;(2)Lidar data provided stable and better estimations than RapidEye data;and stratification of vegetation types cannot improve estimation;(3)The combination of lidar and RapidEye data cannot provide better performance than lidar data alone;(4)AGB ranges affect the selection of the best AGB models,and a combination of different estimation results from the best model for each AGB range can improve AGB estimation;(5)This research implies that an optimal procedure for AGB estimation for a specific study exists,depending on the careful selection of data sources,modeling algorithms,forest types,and AGB ranges.
基金G.R.C.thanks Coordenacao de Aperfeicoamento de Pessoal de Nível Superior–CAPES(88881.068430-2014-01)Conselho Nacional de Desenvolvimento Científico e Tecnológico–CNPq(457587-2012-1)Fundacao de ApoioàPesquisa do Distrito Federal–FAPDF and the USAID’s PEER program under cooperative agreement AIDOAA-A-11-00012 for financial support.
文摘Aims Different plant functional groups display diverging responses to the same environmental gradients.Here,we assess the effects of environmental and spatial predictors on species turnover of three functional groups of Brazilian savannas(Cerrado)plants—trees,palms and lianas—across the transition zone between the Cerrado and Amazon biomes in central Brazil.Methods We used edaphic,climatic and plant composition data from nine one-hectare plots to assess the effects of the environment and space on species turnover using a Redundancy Analysis and Generalized Dissimilarity Modeling(GDM),associated with variance partitioning.Important Findings We recorded 167 tree species,5 palms and 4 liana species.Environmental variation was most important in explaining species turnover,relative to geographic distance,but the best predictors differed between functional groups:geographic distance and silt for lianas;silt for palms;geographic distance,temperature and elevation for trees.Geographic distances alone exerted little influence over species turnover for the three functional groups.The pure environmental variation explained most of the liana and palm turnover,while tree turnover was largely explained by the shared spatial and environmental contribution.The effects of geographic distance upon species turnover leveled off at about 300 km for trees,and 200 km for lianas,whereas they were unimportant for palm species turnover.Our results indicate that environmental factors that determine floristic composition and species turnover differ substantially between plant functional groups in savannas.Therefore,we recommend that studies that aim to investigate the role of environmental conditions in determining plant species turnover should examine plant functional groups separately.
文摘Depending on the magnitude and nature of a disaster,identifying the victims can be a complex task that requires coordinated work by disaster victim identification(DVI)teams based on pre-established protocols.Thus,the analysis of fingerprints has been presented as a method to establish,when possible,the identity of the victims during the DVI process.This study discusses the importance of this primary method of identification and the results obtained in four different disasters in which Brazilian DVI teams were involved:the Air France Flight AF447 plane crash in the Atlantic Ocean,floods and mudslides in the State of Rio de Janeiro,Brazil,the LaMia Flight 2933 plane crash in Colombia,and the tailings dam collapse in Brumadinho,Brazil.Here,we also report the use of the automatic fingerprint capture and identification system,called Alethia,developed by the Federal Police of Brazil and used in the victim identification process in the two latter events mentioned above.
