IGRS Alliance（IGRS Information Industry Association）,founded by eight top-ranking Chinese companies,is an advanced industry platform featured with standardization,industrialization and internationalization,which has...IGRS Alliance（IGRS Information Industry Association）,founded by eight top-ranking Chinese companies,is an advanced industry platform featured with standardization,industrialization and internationalization,which has developed various international standards on smart education,smart devices,smart house appliance,smart audio,etc.,and established the innovation-driven Industry Alliance-National Engineering Laboratory- Industrial Engineering Center.展开更多
Standardization Administration of China has recently issued the Opinions on Promoting the High-quality Development of Association Standards jointly with other 16 ministries and national departments,aiming to put in pl...Standardization Administration of China has recently issued the Opinions on Promoting the High-quality Development of Association Standards jointly with other 16 ministries and national departments,aiming to put in place the National Standardization Development Outline,regulate association standardization and facilitate the healthy development of association standards in China.展开更多
Plant-specific transcriptional regulators called TELOMERE REPEAT BINDING proteins(TRBs)combine two DNA-binding domains,the GH1 domain,which binds to linker DNA and is shared with H1 histones,and the Myb/SANT domain,wh...Plant-specific transcriptional regulators called TELOMERE REPEAT BINDING proteins(TRBs)combine two DNA-binding domains,the GH1 domain,which binds to linker DNA and is shared with H1 histones,and the Myb/SANT domain,which specifically recognizes the telobox DNA-binding site motif.TRB1,TRB2,and TRB3 proteins recruit Polycomb group complex 2(PRC2)to deposit H3K27me3 and JMJ14 to remove H3K4me3 at gene promoters containing telobox motifs to repress transcription.Here,we demonstrate that TRB4 and TRB5,two related paralogs belonging to a separate TRB clade conserved in spermatophytes,regulate the transcription of several hundred genes involved in developmental responses to environmental cues.TRB4 binds to several thousand sites in the genome,mainly at transcription start sites and promoter regions of transcriptionally active and H3K4me3-marked genes,but,unlike TRB1,it is not enriched at H3K27me3-marked gene bodies.However,TRB4 can physically interact with the catalytic components of PRC2,SWINGER,and CURLY LEAF(CLF).Unexpectedly,we show that TRB4 and TRB5 are required for distinctive phenotypic traits observed in clf mutant plants and thus function as transcriptional activators of several hundred CLF-controlled genes,including key flowering genes.We further demonstrate that TRB4 shares multiple target genes with TRB1 and physically and genetically interacts with members of both TRB clades.Collectively,these results reveal that TRB proteins engage in both positive and negative interactions with other members of the family to regulate plant development through both PRC2-dependent and-independent mechanisms.展开更多
文摘IGRS Alliance（IGRS Information Industry Association）,founded by eight top-ranking Chinese companies,is an advanced industry platform featured with standardization,industrialization and internationalization,which has developed various international standards on smart education,smart devices,smart house appliance,smart audio,etc.,and established the innovation-driven Industry Alliance-National Engineering Laboratory- Industrial Engineering Center.
文摘Standardization Administration of China has recently issued the Opinions on Promoting the High-quality Development of Association Standards jointly with other 16 ministries and national departments,aiming to put in place the National Standardization Development Outline,regulate association standardization and facilitate the healthy development of association standards in China.
文摘Plant-specific transcriptional regulators called TELOMERE REPEAT BINDING proteins(TRBs)combine two DNA-binding domains,the GH1 domain,which binds to linker DNA and is shared with H1 histones,and the Myb/SANT domain,which specifically recognizes the telobox DNA-binding site motif.TRB1,TRB2,and TRB3 proteins recruit Polycomb group complex 2(PRC2)to deposit H3K27me3 and JMJ14 to remove H3K4me3 at gene promoters containing telobox motifs to repress transcription.Here,we demonstrate that TRB4 and TRB5,two related paralogs belonging to a separate TRB clade conserved in spermatophytes,regulate the transcription of several hundred genes involved in developmental responses to environmental cues.TRB4 binds to several thousand sites in the genome,mainly at transcription start sites and promoter regions of transcriptionally active and H3K4me3-marked genes,but,unlike TRB1,it is not enriched at H3K27me3-marked gene bodies.However,TRB4 can physically interact with the catalytic components of PRC2,SWINGER,and CURLY LEAF(CLF).Unexpectedly,we show that TRB4 and TRB5 are required for distinctive phenotypic traits observed in clf mutant plants and thus function as transcriptional activators of several hundred CLF-controlled genes,including key flowering genes.We further demonstrate that TRB4 shares multiple target genes with TRB1 and physically and genetically interacts with members of both TRB clades.Collectively,these results reveal that TRB proteins engage in both positive and negative interactions with other members of the family to regulate plant development through both PRC2-dependent and-independent mechanisms.
