Rapid evolutions of the Internet of Electric Vehicles(IoEVs)are reshaping and modernizing transport systems,yet challenges remain in energy efficiency,better battery aging,and grid stability.Typical charging methods a...Rapid evolutions of the Internet of Electric Vehicles(IoEVs)are reshaping and modernizing transport systems,yet challenges remain in energy efficiency,better battery aging,and grid stability.Typical charging methods allow for EVs to be charged without thought being given to the condition of the battery or the grid demand,thus increasing energy costs and battery aging.This study proposes a smart charging station with an AI-powered Battery Management System(BMS),developed and simulated in MATLAB/Simulink,to increase optimality in energy flow,battery health,and impractical scheduling within the IoEV environment.The system operates through real-time communication,load scheduling based on priorities,and adaptive charging based on batterymathematically computed State of Charge(SOC),State of Health(SOH),and thermal state,with bidirectional power flow(V2G),thus allowing EVs’participation towards grid stabilization.Simulation results revealed that the proposed model can reduce peak grid load by 37.8%;charging efficiency is enhanced by 92.6%;battery temperature lessened by 4.4℃;SOH extended over 100 cycles by 6.5%,if compared against the conventional technique.By this way,charging time was decreased by 12.4% and energy costs dropped by more than 20%.These results showed that smart charging with intelligent BMS can boost greatly the operational efficiency and sustainability of the IoEV ecosystem.展开更多
The results of the 2022-2025 study conducted for the vulnerability assessment of pastures and for the development of improvement measures on the degraded land sections in the arid and semi-arid provinces of the Caucas...The results of the 2022-2025 study conducted for the vulnerability assessment of pastures and for the development of improvement measures on the degraded land sections in the arid and semi-arid provinces of the Caucasus under the global climate change conditions are introduced in the current article.The main goal of our scientific work is to study and assess the current ecological and resource state of natural phytocenoses,pastures and hayfields in the arid and semi-arid landscapes under climate change.The paper presents the results of determining the areas and levels of degradation of the natural biogeocenoses and biogeocenoses of the pastures and hayfields in the mountain and highland landscapes.The results were obtained using remote sensing,field and laboratory studies and analyses.The conducted studies have revealed that along 34,174.5 ha pasture and 1342.0 meadows areas of the pastures at the Areni,Yeghegis,Yeghegnadzor and Vayq consolidated administrative territories situated in the arid and semi-arid zones of the Vayots Dzor Region high degradation was recorded in about 6508 hectares of pasture and 407 hectares of meadows areas,which is related to irregular and uncontrolled economic mismanagement of the local population and global climate change.To improve the ecological condition,accessibility and quality of ecosystem services of the pastures,hayfields and natural meadows,comprehensive restoration bioecological and agrotechnical measures have been proposed.They are aimed at improving the air,water and nutrient regimes of soils,at their bioprotection,as well as at the general increase in area and at improving the economic characteristics of the vegetation cover.Such measures on the ecosystem basis are appropriate in the context of enriching the qualitative composition of plants with useful ecological and economic bioecological characteristics,taking into account the characteristics of landscapes,weather and climatic conditions,and agricultural opportunities.展开更多
This review provides a comprehensive overview of recent advancements in aluminum-based conductor alloys engineered to achieve superior mechanical strength and thermal stability without sacrificing electrical conductiv...This review provides a comprehensive overview of recent advancements in aluminum-based conductor alloys engineered to achieve superior mechanical strength and thermal stability without sacrificing electrical conductivity.Particular emphasis is placed on the role of microalloying elements—particularly Sc and Zr-in promoting the formation of coherent nanoscale precipitates such as Al_(3)Zr,Al_(3)Sc,and core-shell Al_(3)(Sc,Zr)with metastable L1_(2)crystal structures.These precipitates contribute significantly to high-temperature performance by enabling precipitation strengthening and stabilizing grain boundaries.The review also explores the emerging role of other rare earth elements(REEs),such as erbium(Er),in accelerating precipitation kinetics and improving thermal stability by retarding coarsening.Additionally,recent advancements in thermomechanical processing strategies are examined,with a focus on scalable approaches to optimize the strength-conductivity balance.These approaches involve multi-step heat treatments and carefully controlled manufacturing sequences,particularly the combination of cold drawing and aging treatment to promote uniform and effective precipitation.This review offers valuable insights to guide the development of cost-effective,high-strength,heat-resistant aluminum alloys beyond conductor applications,particularly those strengthened through microalloying with Sc and Zr.展开更多
Anion-exchange membrane water electrolysers(AEMWEs)and fuel cells(AEMFCs)are critical technologies for converting renewable resources into green hydrogen(H_(2)),where anion-exchange membranes(AEMs)play a vital role in...Anion-exchange membrane water electrolysers(AEMWEs)and fuel cells(AEMFCs)are critical technologies for converting renewable resources into green hydrogen(H_(2)),where anion-exchange membranes(AEMs)play a vital role in efficiently transporting hydroxide ions(OH^(-))and minimizing fuel crossover,thus enhancing overall efficiency.While conventional AEMs with linear,side-chain,and block polymer architectures show promise through functionalization,their long-term performance remains a concern.To address this,hyperbranched polymers offer a promising alternative due to their three-dimensional structure,higher terminal functionality,and ease of functionalization.This unique architecture provides interconnected ion transport pathways,fractional free volume,and enhanced long-term stability in alkaline environments.Recent studies have achieved conductivities as high as 304.5 mS cm^(-1),attributed to their improved fractional free volume and microphase separation in hyperbranched AEMs.This review explores the chemical,mechanical,and ionic properties of hyperbranched AEMs in AEMFCs and assesses their potential for application in AEMWEs.Strategies such as blending and structural functionalisation have significantly improved the properties by promoting microphase separation and increasing the density of cationic groups on the polymer surface.The review provides essential insights for future research,highlighting the challenges and opportunities in developing high-performance hyperbranched AEMs to advance hydrogen energy infrastructure.展开更多
Acute pancreatitis(AP)is sudden inflammation of the pancreas,which can lead to multiple organ dysfunction in severe cases.Hypertriglyceridemia(HTG)is the third most common cause.In recent years,HTG-induced AP(HTG-AP)h...Acute pancreatitis(AP)is sudden inflammation of the pancreas,which can lead to multiple organ dysfunction in severe cases.Hypertriglyceridemia(HTG)is the third most common cause.In recent years,HTG-induced AP(HTG-AP)has garnered increasing attention.Compared to AP caused by other causes,HTG-AP often has a more subtle onset but is more likely to progress to a severe,critical illness that poses a serious threat to a patient’s life and health.Research suggests a potential connection between the gut microbiota and AP,which could be mediated by bacterial metabolites,immune cells,and inflammatory factors.This is supported by observations of microbial imbalance and higher intestinal permeability in patients with AP.In addition,studies have shown that HTG-induced changes in gut microbiota can worsen AP by negatively impacting the host metabolism,immune response,and function of the intestinal barrier.In this review,we summarize recent clinical and animal studies on the role and mechanism of gut microbiota in the severity of AP aggravated by HTG.The application prospects of the newly proposed microbial-host-isozyme concept are summarized,focusing on its potential for the precision diagnosis and treatment of HTG-AP through gut microbiota regulation.展开更多
The aim of this paper was to characterize through experiment the moisture and temperature kinetic behavior of Eucalyptus gomphocephala wood samples using microwave heating(MWH)in two scenarios:intermittently and conti...The aim of this paper was to characterize through experiment the moisture and temperature kinetic behavior of Eucalyptus gomphocephala wood samples using microwave heating(MWH)in two scenarios:intermittently and continuously.The mechanical properties and surface appearance of the heated samples were also investigated.Continuous and intermittent microwave drying kinetic experiments were conducted at a frequency of 2.45 GHz using a microwave laboratory oven at 300,500,and 1000 watts.Drying rate curves indicated three distinct phases of MWH.Increasing the microwave power with a shorter drying time led to rapid increases in internal temperature and water evaporation rates of the heated samples.Mechanical results indicated that samples heated under continuous MW(Microwave)power at 300 watts had a modulus of rupture(MOR)and modulus of elasticity(MOE)in three static bending tests higher than 29%and 36%,respectively,than samples heated at 1000 watts.Intermittent microwave heating(IMWH)of samples at 300 and 1000 watts produced the highest MOR and MOE values of 31%and 51%,respectively,unlike those heated under continuous microwave heating(CMWH).External qualitative observation showed that samples heated at high microwave power had severe surface checks.These defects were missing when using IMWH.An analysis of variance(ANOVA)showed that mechanical properties were linked to both microwave power level and the heating scenario,except for MOR in axial compression under CMWH.展开更多
AIM:This paper describes the procedure of detection of Helicobacter pylori(H.pylori)in bile specimens in patients suffering from benign diseases of biliary ducts(lithiasis with/without nonspecific cholangitis). METHOD...AIM:This paper describes the procedure of detection of Helicobacter pylori(H.pylori)in bile specimens in patients suffering from benign diseases of biliary ducts(lithiasis with/without nonspecific cholangitis). METHODS:The group of 72 patients entering the study consisted of 32 male and 40 female(45 % and 55 %, respectively).Bile was obtained during ERCP in 68 patients, and during cholecystectomy in 4 patients.A fast urease test (FUT)to determine the existence of H.pylori in gastric mucosa was carried out for all the patients during the endoscopic examination.The existence of genetic material of H.pylori was determined by detection of ure A gene by the method of nested PCR.The results of this reaction were shown by electrophoresis on 10 g·L^(-1)agarose gel in a band of 256 bp. RESULTS:The majority of the patients included in our study had biliary lithiasis without signs of cholangitis(48 patients, 67 %),whereas other patients were complicated by cholangitis(17 patients,24 %).Seven patients(9 %)had normal ERCP,forming thus the control group.In the group of patients with lithiasis 26 patients(24.2 %)had positive PCR of H.pylori in bile and among the patients with associated cholangitis positive PCR was detected in 9 patients(52.9 %).Among the seven patients with normal ERCP only one(14 %)had positive PCR of H.pylori.A high percentage of H.pylori infection of gastric mucosa was observed(57 patients,79 %).It was also observed that its slightly higher positivity was in the patients with distinct bile pathology:81% FLIT positive patients in the group with choledocholithiasis alone and 76 % in the group with choledocholithiasis associated with cholangitis.Seventy-one percent of the patients with regular findings had positive FUT.CONCLUSION: The prevalence of H. pylori infection both in bile and in gastric mucosa in patients with benign diseases of biliary ducts does not show a statistically significant difference in relation to the prevalence of the same with the patients with normal ERCP. The existence of H. pylori infection possibly does not play a role in pathogenesis of benign biliary diseases.展开更多
The low efficiency of phytoextraction of lead(Pb)from agricultural fields poses a significant agricultural challenge.Organic chelating agents can influence Pb bioavailability in soil,affecting its uptake,transport,and...The low efficiency of phytoextraction of lead(Pb)from agricultural fields poses a significant agricultural challenge.Organic chelating agents can influence Pb bioavailability in soil,affecting its uptake,transport,and toxicity in plants.This study aimed to assess the impact of citric acid(CA)and diethylenetriaminepentaacetic acid(DTPA)on chelate-assisted phytoextraction of Pb and its effect on growth and physiology of two cultivars(07001;07002)of mung bean(Vigna radiata).The cultivars of mung bean were exposed to 60 lead chloride(PbCl_(2))solution,mg⋅L-1with or without the addition of 300 CA or 500 DTPA,until maturity.The exposure of plants to Pb mg⋅L^(-1) mg⋅L^(-1) stress increased the accumulation of Pb in roots(49%of control),stems(58%of control),leaves(67%of control),and seeds(61%of control).Maximum accumulation of Pb was observed in roots and the least accumulation was found in seeds of both mung bean cultivars.The extent of Pb accumulation in different plant parts correlated positively with Pb toxicity and reduced growth of both mung bean cultivars(33%to 40%).The cultivar cv 07001 was more susceptible to Pb stress.The addition of CA and DTPA increased the accumulation of Pb in plant parts of mung bean cultivars-phytoextraction(10.8%to 21.5%).However,the addition of CA partitioned Pb in vegetative parts,i.e.,root,stem thus mitigated the toxic effects of Pb on the growth of mung bean cultivars(6.25%–10.5%).In contrast,the addition of DTPA had adverse effects on the growth of mung bean cultivars.The addition of CA facilitated a greater uptake and accumulation of nitrogen,phosphorous,and potassium in the roots and leaves of mung bean cultivars.In addition,CA also improved the photosynthetic pigments(11%–14%)and photosynthetic rate(5%–12%)under both control and Pb stress conditions.The ameliorative effect of CA on the photosynthetic capacity of mung bean cultivars was likely associated with photosynthetic metabolic factors rather than stomatal factors.Furthermore,cv 07002 was found to be more tolerant to Pb stress and showed better performance in CA application.Overall,the application of CA demonstrated significant potential as a chelating agent for remediating Pb-contaminated soil.展开更多
Titanium exhibits outstanding properties,particularly,high specific strength and resistance to both high and low temperatures,earning it a reputation as the metal of the future.However,because of the highly reactive n...Titanium exhibits outstanding properties,particularly,high specific strength and resistance to both high and low temperatures,earning it a reputation as the metal of the future.However,because of the highly reactive nature of titanium,metallic titanium production involves extensive procedures and high costs.Considering its advantages and limitations,the European Union has classified titanium metal as a critical raw material(CRM)of low category.The Kroll process is predominantly used to produce titanium;however,molten salt electrolysis(MSE)is currently being explored for producing metallic titanium at a low cost.Since 2000,electrolytic titanium production has undergone a wave of technological advancements.However,because of the intermediate and disproportionation reactions in the electrolytic titanium production process,the process efficiency and titanium purity according to industrial standards could not be achieved.Consequently,metallic titanium production has gradually diversified into employing technologies such as thermal reduction,MSE,and titanium alloy preparation.This study provides a comprehensive review of research advances in titanium metal preparation technologies over the past two decades,highlighting the challenges faced by the existing methods and proposing potential solutions.It offers useful insights into the development of low-cost titanium preparation technologies.展开更多
This study proposes and systematically evaluates an optimized integration of warm surface seawater injection with depressurization for the long-term exploitation of marine natural gas hydrates.By employing comprehensi...This study proposes and systematically evaluates an optimized integration of warm surface seawater injection with depressurization for the long-term exploitation of marine natural gas hydrates.By employing comprehensive multiphysics simulations guided by field data from hydrate production tests in the South China Sea,we pinpoint key operational parameters—such as injection rates,depths,and timings—that notably enhance production efficiency.The results indicate that a 3-phase hydrate reservoir transitions from a free-gas-dominated production stage to a hydrate-decomposition-dominated stage.Moderate warm seawater injection supplies additional heat during the hydrate decomposition phase,thereby enhancing stable production;however,excessively high injection rates can impede the depressurization process.Only injection at an appropriate depth simultaneously balances thermal supplementation and the pressure gradient,leading to higher overall productivity.A“depressurization-driven sensible-heat supply window”is introduced,highlighting that timely seawater injection following initial depressurization prolongs reservoir dissociation dynamics.In this study area,commencing seawater injection at 170 d of depressurization proved optimal.This optimized integration leverages clean and renewable thermal energy,providing essential insights into thermal supplementation strategies with significant implications for sustainable,economically feasible,and efficient commercial-scale hydrate production.展开更多
This review comprehensively summarized the potential of artificial intelligence(AI)in the management of esophageal cancer.It highlighted the significance of AI-assisted endoscopy in Japan where endoscopy is central to...This review comprehensively summarized the potential of artificial intelligence(AI)in the management of esophageal cancer.It highlighted the significance of AI-assisted endoscopy in Japan where endoscopy is central to both screening and diagnosis.For the clinical adaptation of AI,several challenges remain for its effective translation.The establishment of high-quality clinical databases,such as the National Clinical Database and Japan Endoscopy Database in Japan,which covers almost all cases of esophageal cancer,is essential for validating multimodal AI models.This requires rigorous external validation using diverse datasets,including those from different endoscope manufacturers and image qualities.Furthermore,endoscopists’skills significantly affect diagnostic accuracy,suggesting that AI should serve as a supportive tool rather than a replacement.Addressing these challenges,along with country-specific legal and ethical considerations,will facilitate the successful integration of multimodal AI into the management of esophageal cancer,particularly in endoscopic diagnosis,and contribute to improved patient outcomes.Although this review focused on Japan as a case study,the challenges and solutions described are broadly applicable to other high-incidence regions.展开更多
Clinically significant Portal hypertension(PH),defined by a hepatic venous pressure gradient(HVPG)greater than 10 mmHg,is a key predictor of decompensation events in cirrhosis,leading to variceal hemorrhage,ascites,an...Clinically significant Portal hypertension(PH),defined by a hepatic venous pressure gradient(HVPG)greater than 10 mmHg,is a key predictor of decompensation events in cirrhosis,leading to variceal hemorrhage,ascites,and hepatic encephalopathy.This narrative review explores the pathophysiology of PH in cirrhosis,evaluates diagnostic methods for identifying clinically significant PH(CSPH),and discusses guideline-driven strategies to prevent initial and further decompensation.While HVPG remains the gold standard for diagnosing CSPH,non-invasive tools such as liver stiffness measurement and spleen stiffness measurement are increasingly used for initial risk stratification.The combined use of these tools reduces the proportion of patients in the diagnostic"grey zone".Endoscopic ultrasound-guided portal pressure gradient is an emerging diagnostic tool that requires further validation.Non-selective beta-blockers are the cornerstone of primary prophylaxis for decompensation,and their combination with endoscopic variceal ligation is the first-line therapy for secondary prophylaxis of recurrent esophageal variceal bleeding.Statins show promise in reducing PH and preventing decompensation while further studies are still needed.This review also discusses the indications for preemptive transjugular intrahepatic portosystemic shunt and its role in managing refractory ascites and variceal bleeding.展开更多
Dear Editor,I am responding to Zou and Li's,The missing perilymph sign on MRI indicates a perilymphatic fistula:A case report Zou J,Li H.Journal of Otology,2025, 20(1):1-4.https://doi.org/10.26599/JOTO.2025.954000...Dear Editor,I am responding to Zou and Li's,The missing perilymph sign on MRI indicates a perilymphatic fistula:A case report Zou J,Li H.Journal of Otology,2025, 20(1):1-4.https://doi.org/10.26599/JOTO.2025.9540001 proposing the"missing perilymph"sign on MRI as a novel radiological indicator of perilymphatic fistula(PLF).This study adds to the growing body of work seeking objective,non-invasive diagnostic methods for PLF,a condition that has long eluded definitive radiological confirmation.The avoidance of gadolinium contrast in the imaging technique is an additional strength,given increasing awareness of gadoliniumassociated risks (Starekova et al.,2024).展开更多
Urethral catheterization is an important skill to develop as consultations for“difficult catheterization”are common in practice.Developing a broad approach to difficult urethral catheterization is crucial to improve...Urethral catheterization is an important skill to develop as consultations for“difficult catheterization”are common in practice.Developing a broad approach to difficult urethral catheterization is crucial to improve trainee success rates.Strategies and techniques to improve catheterization success are often passed down and shared between trainees without formal documentation or dissemination of techniques.Herein,we present a framework for difficult urethral catheterization based on clinical history and patient examination,while also providing additional techniques and troubleshooting to overcome common challenges with urethral catheterization in adult and pediatric patients.展开更多
Lymphedema,particularly in its advanced stages,presents significant challenges in treatment,often necessitating a combination of therapies to manage symptoms effectively and improve patient outcomes.This article revie...Lymphedema,particularly in its advanced stages,presents significant challenges in treatment,often necessitating a combination of therapies to manage symptoms effectively and improve patient outcomes.This article reviews the findings of Wang et al,regarding the use of lymphovenous anastomosis and complex decongestive therapy in treating severe,deformed stage III lymphedema with recurrent infections.The case report details the promising results achieved through this combined therapy,highlighting substantial reductions in limb volume and the complete resolution of recurrent lymphangitis.The patient experienced notable improvements in weight loss,physical function,and quality of life.Despite its strengths,the study has several limitations.It lacks specific details on the types of lymphovenous anastomoses performed and complex decongestive therapy protocols,such as frequency and adherence,making reproducibility difficult.The short follow-up period of six months limits understanding of long-term efficacy,and more consistent reporting of key metrics such as weight loss and body mass index would enhance outcome assessments.This article emphasizes the importance of integrating minimally invasive surgical techniques with conservative therapies to address both the symptoms and underlying causes of lymphedema.Further research is essential to standardize protocols and refine combined treatment strategies.展开更多
BACKGROUND Second-line treatment of Crohn’s disease(CD)commonly involves immunosuppressants such as azathioprine,mercaptopurine,or methotrexate(MTX),used either alone or in combination.AIM To investigate the current ...BACKGROUND Second-line treatment of Crohn’s disease(CD)commonly involves immunosuppressants such as azathioprine,mercaptopurine,or methotrexate(MTX),used either alone or in combination.AIM To investigate the current use of MTX among French gastroenterologists.METHODS An online questionnaire was distributed between March and August 2023 to 116 French gastroenterologists managing CD.A total of 87 respondents completed the survey and were included in the analysis.RESULTS Respondents reported a mean annual caseload of 140 CD patients(median:50).Overall,71%prescribed MTX,predominantly in injectable form(92%),either as monotherapy or in combination with biologics or cyclosporin.MTX was prescribed for mild-to-moderate CD by 64%of respondents,and for severe CD by 58%,often in combination with an anti-tumor necrosis factor agent(89%and 94%,respectively).Injectable MTX was favored(84%)in specific clinical scenarios:Patients with articular manifestations(77%),Epstein-Barr virus-negative status(65%),or aged over 65 years(58%).Among the 29%of non-prescribers,the primary reason cited was lack of familiarity with MTX use(60%).Both prescribers and non-prescribers expressed the need for clearer guidelines and real-world data to support MTX use.CONCLUSION Regardless of prescribing habits,most respondents had a favorable opinion of MTX and recognized its good longterm safety profile.French learned societies and medical associations should provide consensus guidelines on MTX use,supported by validated real-world safety and effectiveness data.展开更多
Background:Stomach cancer(SC)is one of the most lethal malignancies worldwide due to late-stage diagnosis and limited treatment.The transcriptomic,epigenomic,and proteomic,etc.,omics datasets generated by high-through...Background:Stomach cancer(SC)is one of the most lethal malignancies worldwide due to late-stage diagnosis and limited treatment.The transcriptomic,epigenomic,and proteomic,etc.,omics datasets generated by high-throughput sequencing technology have become prominent in biomedical research,and they reveal molecular aspects of cancer diagnosis and therapy.Despite the development of advanced sequencing technology,the presence of high-dimensionality in multi-omics data makes it challenging to interpret the data.Methods:In this study,we introduce RankXLAN,an explainable ensemble-based multi-omics framework that integrates feature selection(FS),ensemble learning,bioinformatics,and in-silico validation for robust biomarker detection,potential therapeutic drug-repurposing candidates’identification,and classification of SC.To enhance the interpretability of the model,we incorporated explainable artificial intelligence(SHapley Additive exPlanations analysis),as well as accuracy,precision,F1-score,recall,cross-validation,specificity,likelihood ratio(LR)+,LR−,and Youden index results.Results:The experimental results showed that the top four FS algorithms achieved improved results when applied to the ensemble learning classification model.The proposed ensemble model produced an area under the curve(AUC)score of 0.994 for gene expression,0.97 for methylation,and 0.96 for miRNA expression data.Through the integration of bioinformatics and ML approach of the transcriptomic and epigenomic multi-omics dataset,we identified potential marker genes,namely,UBE2D2,HPCAL4,IGHA1,DPT,and FN3K.In-silico molecular docking revealed a strong binding affinity between ANKRD13C and the FDA-approved drug Everolimus(binding affinity−10.1 kcal/mol),identifying ANKRD13C as a potential therapeutic drug-repurposing target for SC.Conclusion:The proposed framework RankXLAN outperforms other existing frameworks for serum biomarker identification,therapeutic target identification,and SC classification with multi-omics datasets.展开更多
Fc Receptor-Like 1(FCRL1),a member of the FCRL family,contains two immunoreceptor tyrosinebased activation motifs(ITAMs)in its cytoplasmic domain and plays a critical role in B-cell biology.Its expression begins in pr...Fc Receptor-Like 1(FCRL1),a member of the FCRL family,contains two immunoreceptor tyrosinebased activation motifs(ITAMs)in its cytoplasmic domain and plays a critical role in B-cell biology.Its expression begins in pre-B-cells,dynamically shifts during B-cell development,and contributes to the regulation of human B-cell activation.Notably,FCRL1 is overexpressed in subsets of naive and memory B-cells,as well as in malignant B-cells,including those in diffuse large B-cell lymphoma(DLBCL),an aggressive and often treatment-resistant hematological malignancy.Among FCRL family members,FCRL1 stands out as a promising immunotherapeutic target due to its selective expression in malignant B-cells and its functional role in proliferation.Given the limited efficacy of current therapies for relapsed/refractory DLBCL,targeting FCRL1 could address an unmet clinical need by offering a novel,mechanism-based approach to modulate B-cell signaling and enhance anti-tumor immunity.This mini-review highlights the therapeutic potential of FCRL1-directed strategies,supporting their further exploration in preclinical models and future clinical trials for DLBCL and other B-cell malignancies.展开更多
This special issue of iRADIOLOGY on the application of in-struments and equipment in medical imaging documents the groundbreaking strides to develop optimal imaging modalities,particularly X‐ray,ultrasound,computed t...This special issue of iRADIOLOGY on the application of in-struments and equipment in medical imaging documents the groundbreaking strides to develop optimal imaging modalities,particularly X‐ray,ultrasound,computed tomography(CT),magnetic resonance imaging(MRI),positron emission tomog-raphy(PET),and single‐photon emission computed tomography(SPECT),to diagnose,treat,cure,and ultimately prevent med-ical disorders.This special issue continues the outstanding contributions of prior special issues on ultra‐high field MRI[1],ultra‐high field MRI in the theranostics of mental disorders[2],artificial intelligence in medical imaging[3],imaging of fetuses,children,and mothers[4],and the use of large language models in radiology[5]to provide readers updates on the state‐of‐the‐art of the application of instruments and equipment in medi-cal imaging to utilize the promising hardware available for optimal interventions in medicine.展开更多
To promote growth,terrestrial plants release photosynthetic products into the rhizosphere in the form of root exudates through their root systems.Under the attraction of root exudates,plant growth-promoting rhizobacte...To promote growth,terrestrial plants release photosynthetic products into the rhizosphere in the form of root exudates through their root systems.Under the attraction of root exudates,plant growth-promoting rhizobacteria(PGPR)colonize the rhizosphere to stimulate plant growth and/or suppress the growth of pathogenic microorganisms.The rhizospheric recruitment of PGPR,as well as the establishment of root-microbe interactions,is initiated by chemotaxis towards root exudates.Over the past several decades,scientists have made notable strides in identifying representative chemoeffectors in root exudates,as well as the corresponding chemoreceptors.We review here the most recent developments in rhizospheric chemotaxis,particularly the chemoeffectors in root exudates,the structural and functional characterization of methyl-accepting chemotaxis proteins of PGPR,and the impacts of rhizospheric chemotaxis on root colonization,biofilm formation,and other root-microbe interactions during recruitment.Finally,we propose several perspectives that aim to fully unlock the potential of PGPR as bioinoculants in sustainable agriculture.展开更多
文摘Rapid evolutions of the Internet of Electric Vehicles(IoEVs)are reshaping and modernizing transport systems,yet challenges remain in energy efficiency,better battery aging,and grid stability.Typical charging methods allow for EVs to be charged without thought being given to the condition of the battery or the grid demand,thus increasing energy costs and battery aging.This study proposes a smart charging station with an AI-powered Battery Management System(BMS),developed and simulated in MATLAB/Simulink,to increase optimality in energy flow,battery health,and impractical scheduling within the IoEV environment.The system operates through real-time communication,load scheduling based on priorities,and adaptive charging based on batterymathematically computed State of Charge(SOC),State of Health(SOH),and thermal state,with bidirectional power flow(V2G),thus allowing EVs’participation towards grid stabilization.Simulation results revealed that the proposed model can reduce peak grid load by 37.8%;charging efficiency is enhanced by 92.6%;battery temperature lessened by 4.4℃;SOH extended over 100 cycles by 6.5%,if compared against the conventional technique.By this way,charging time was decreased by 12.4% and energy costs dropped by more than 20%.These results showed that smart charging with intelligent BMS can boost greatly the operational efficiency and sustainability of the IoEV ecosystem.
基金the framework of the Project 21T-4C045 of the Higher Education and Science Committee(RA)。
文摘The results of the 2022-2025 study conducted for the vulnerability assessment of pastures and for the development of improvement measures on the degraded land sections in the arid and semi-arid provinces of the Caucasus under the global climate change conditions are introduced in the current article.The main goal of our scientific work is to study and assess the current ecological and resource state of natural phytocenoses,pastures and hayfields in the arid and semi-arid landscapes under climate change.The paper presents the results of determining the areas and levels of degradation of the natural biogeocenoses and biogeocenoses of the pastures and hayfields in the mountain and highland landscapes.The results were obtained using remote sensing,field and laboratory studies and analyses.The conducted studies have revealed that along 34,174.5 ha pasture and 1342.0 meadows areas of the pastures at the Areni,Yeghegis,Yeghegnadzor and Vayq consolidated administrative territories situated in the arid and semi-arid zones of the Vayots Dzor Region high degradation was recorded in about 6508 hectares of pasture and 407 hectares of meadows areas,which is related to irregular and uncontrolled economic mismanagement of the local population and global climate change.To improve the ecological condition,accessibility and quality of ecosystem services of the pastures,hayfields and natural meadows,comprehensive restoration bioecological and agrotechnical measures have been proposed.They are aimed at improving the air,water and nutrient regimes of soils,at their bioprotection,as well as at the general increase in area and at improving the economic characteristics of the vegetation cover.Such measures on the ecosystem basis are appropriate in the context of enriching the qualitative composition of plants with useful ecological and economic bioecological characteristics,taking into account the characteristics of landscapes,weather and climatic conditions,and agricultural opportunities.
文摘This review provides a comprehensive overview of recent advancements in aluminum-based conductor alloys engineered to achieve superior mechanical strength and thermal stability without sacrificing electrical conductivity.Particular emphasis is placed on the role of microalloying elements—particularly Sc and Zr-in promoting the formation of coherent nanoscale precipitates such as Al_(3)Zr,Al_(3)Sc,and core-shell Al_(3)(Sc,Zr)with metastable L1_(2)crystal structures.These precipitates contribute significantly to high-temperature performance by enabling precipitation strengthening and stabilizing grain boundaries.The review also explores the emerging role of other rare earth elements(REEs),such as erbium(Er),in accelerating precipitation kinetics and improving thermal stability by retarding coarsening.Additionally,recent advancements in thermomechanical processing strategies are examined,with a focus on scalable approaches to optimize the strength-conductivity balance.These approaches involve multi-step heat treatments and carefully controlled manufacturing sequences,particularly the combination of cold drawing and aging treatment to promote uniform and effective precipitation.This review offers valuable insights to guide the development of cost-effective,high-strength,heat-resistant aluminum alloys beyond conductor applications,particularly those strengthened through microalloying with Sc and Zr.
基金UKRI financial support under grant number EP/Y026098/1 for Global Hydrogen Production Technologies(HyPT)Center。
文摘Anion-exchange membrane water electrolysers(AEMWEs)and fuel cells(AEMFCs)are critical technologies for converting renewable resources into green hydrogen(H_(2)),where anion-exchange membranes(AEMs)play a vital role in efficiently transporting hydroxide ions(OH^(-))and minimizing fuel crossover,thus enhancing overall efficiency.While conventional AEMs with linear,side-chain,and block polymer architectures show promise through functionalization,their long-term performance remains a concern.To address this,hyperbranched polymers offer a promising alternative due to their three-dimensional structure,higher terminal functionality,and ease of functionalization.This unique architecture provides interconnected ion transport pathways,fractional free volume,and enhanced long-term stability in alkaline environments.Recent studies have achieved conductivities as high as 304.5 mS cm^(-1),attributed to their improved fractional free volume and microphase separation in hyperbranched AEMs.This review explores the chemical,mechanical,and ionic properties of hyperbranched AEMs in AEMFCs and assesses their potential for application in AEMWEs.Strategies such as blending and structural functionalisation have significantly improved the properties by promoting microphase separation and increasing the density of cationic groups on the polymer surface.The review provides essential insights for future research,highlighting the challenges and opportunities in developing high-performance hyperbranched AEMs to advance hydrogen energy infrastructure.
基金Supported by the Innovation Foundation for Doctor Dissertation of Northwestern Polytechnical University,No.CX2023021.
文摘Acute pancreatitis(AP)is sudden inflammation of the pancreas,which can lead to multiple organ dysfunction in severe cases.Hypertriglyceridemia(HTG)is the third most common cause.In recent years,HTG-induced AP(HTG-AP)has garnered increasing attention.Compared to AP caused by other causes,HTG-AP often has a more subtle onset but is more likely to progress to a severe,critical illness that poses a serious threat to a patient’s life and health.Research suggests a potential connection between the gut microbiota and AP,which could be mediated by bacterial metabolites,immune cells,and inflammatory factors.This is supported by observations of microbial imbalance and higher intestinal permeability in patients with AP.In addition,studies have shown that HTG-induced changes in gut microbiota can worsen AP by negatively impacting the host metabolism,immune response,and function of the intestinal barrier.In this review,we summarize recent clinical and animal studies on the role and mechanism of gut microbiota in the severity of AP aggravated by HTG.The application prospects of the newly proposed microbial-host-isozyme concept are summarized,focusing on its potential for the precision diagnosis and treatment of HTG-AP through gut microbiota regulation.
文摘The aim of this paper was to characterize through experiment the moisture and temperature kinetic behavior of Eucalyptus gomphocephala wood samples using microwave heating(MWH)in two scenarios:intermittently and continuously.The mechanical properties and surface appearance of the heated samples were also investigated.Continuous and intermittent microwave drying kinetic experiments were conducted at a frequency of 2.45 GHz using a microwave laboratory oven at 300,500,and 1000 watts.Drying rate curves indicated three distinct phases of MWH.Increasing the microwave power with a shorter drying time led to rapid increases in internal temperature and water evaporation rates of the heated samples.Mechanical results indicated that samples heated under continuous MW(Microwave)power at 300 watts had a modulus of rupture(MOR)and modulus of elasticity(MOE)in three static bending tests higher than 29%and 36%,respectively,than samples heated at 1000 watts.Intermittent microwave heating(IMWH)of samples at 300 and 1000 watts produced the highest MOR and MOE values of 31%and 51%,respectively,unlike those heated under continuous microwave heating(CMWH).External qualitative observation showed that samples heated at high microwave power had severe surface checks.These defects were missing when using IMWH.An analysis of variance(ANOVA)showed that mechanical properties were linked to both microwave power level and the heating scenario,except for MOR in axial compression under CMWH.
基金Gastrointestinal Research Laboratory,Department of Medicine,University of Rostock,Germany
文摘AIM:This paper describes the procedure of detection of Helicobacter pylori(H.pylori)in bile specimens in patients suffering from benign diseases of biliary ducts(lithiasis with/without nonspecific cholangitis). METHODS:The group of 72 patients entering the study consisted of 32 male and 40 female(45 % and 55 %, respectively).Bile was obtained during ERCP in 68 patients, and during cholecystectomy in 4 patients.A fast urease test (FUT)to determine the existence of H.pylori in gastric mucosa was carried out for all the patients during the endoscopic examination.The existence of genetic material of H.pylori was determined by detection of ure A gene by the method of nested PCR.The results of this reaction were shown by electrophoresis on 10 g·L^(-1)agarose gel in a band of 256 bp. RESULTS:The majority of the patients included in our study had biliary lithiasis without signs of cholangitis(48 patients, 67 %),whereas other patients were complicated by cholangitis(17 patients,24 %).Seven patients(9 %)had normal ERCP,forming thus the control group.In the group of patients with lithiasis 26 patients(24.2 %)had positive PCR of H.pylori in bile and among the patients with associated cholangitis positive PCR was detected in 9 patients(52.9 %).Among the seven patients with normal ERCP only one(14 %)had positive PCR of H.pylori.A high percentage of H.pylori infection of gastric mucosa was observed(57 patients,79 %).It was also observed that its slightly higher positivity was in the patients with distinct bile pathology:81% FLIT positive patients in the group with choledocholithiasis alone and 76 % in the group with choledocholithiasis associated with cholangitis.Seventy-one percent of the patients with regular findings had positive FUT.CONCLUSION: The prevalence of H. pylori infection both in bile and in gastric mucosa in patients with benign diseases of biliary ducts does not show a statistically significant difference in relation to the prevalence of the same with the patients with normal ERCP. The existence of H. pylori infection possibly does not play a role in pathogenesis of benign biliary diseases.
基金funding from the Ongoing Research Funding program,ORF-2025-298,King Saud University,Riyadh,Saudi Arabia.
文摘The low efficiency of phytoextraction of lead(Pb)from agricultural fields poses a significant agricultural challenge.Organic chelating agents can influence Pb bioavailability in soil,affecting its uptake,transport,and toxicity in plants.This study aimed to assess the impact of citric acid(CA)and diethylenetriaminepentaacetic acid(DTPA)on chelate-assisted phytoextraction of Pb and its effect on growth and physiology of two cultivars(07001;07002)of mung bean(Vigna radiata).The cultivars of mung bean were exposed to 60 lead chloride(PbCl_(2))solution,mg⋅L-1with or without the addition of 300 CA or 500 DTPA,until maturity.The exposure of plants to Pb mg⋅L^(-1) mg⋅L^(-1) stress increased the accumulation of Pb in roots(49%of control),stems(58%of control),leaves(67%of control),and seeds(61%of control).Maximum accumulation of Pb was observed in roots and the least accumulation was found in seeds of both mung bean cultivars.The extent of Pb accumulation in different plant parts correlated positively with Pb toxicity and reduced growth of both mung bean cultivars(33%to 40%).The cultivar cv 07001 was more susceptible to Pb stress.The addition of CA and DTPA increased the accumulation of Pb in plant parts of mung bean cultivars-phytoextraction(10.8%to 21.5%).However,the addition of CA partitioned Pb in vegetative parts,i.e.,root,stem thus mitigated the toxic effects of Pb on the growth of mung bean cultivars(6.25%–10.5%).In contrast,the addition of DTPA had adverse effects on the growth of mung bean cultivars.The addition of CA facilitated a greater uptake and accumulation of nitrogen,phosphorous,and potassium in the roots and leaves of mung bean cultivars.In addition,CA also improved the photosynthetic pigments(11%–14%)and photosynthetic rate(5%–12%)under both control and Pb stress conditions.The ameliorative effect of CA on the photosynthetic capacity of mung bean cultivars was likely associated with photosynthetic metabolic factors rather than stomatal factors.Furthermore,cv 07002 was found to be more tolerant to Pb stress and showed better performance in CA application.Overall,the application of CA demonstrated significant potential as a chelating agent for remediating Pb-contaminated soil.
基金financial support from the Yunnan Province Key Industries Science and Technology Special Project for Colleges and UniversitiesChina(No.FWCY-QYCT2024006)+6 种基金National Natural Science Foundation of China(Nos.52104351 and 52364051)Science and Technology Major Project of Yunnan Province,China(No.202202AG050007)the Yunnan Fundamental Research ProjectsChina(No.202401AT070314)the Key Technology Research and Development Program of Shandong Province,China(No.2023CXGC010903)Central Guidance Local Scientific and Technological Development Funds,China(No.202407AB110022)Yunnan Province Xingdian Talent Support Plan Project,China。
文摘Titanium exhibits outstanding properties,particularly,high specific strength and resistance to both high and low temperatures,earning it a reputation as the metal of the future.However,because of the highly reactive nature of titanium,metallic titanium production involves extensive procedures and high costs.Considering its advantages and limitations,the European Union has classified titanium metal as a critical raw material(CRM)of low category.The Kroll process is predominantly used to produce titanium;however,molten salt electrolysis(MSE)is currently being explored for producing metallic titanium at a low cost.Since 2000,electrolytic titanium production has undergone a wave of technological advancements.However,because of the intermediate and disproportionation reactions in the electrolytic titanium production process,the process efficiency and titanium purity according to industrial standards could not be achieved.Consequently,metallic titanium production has gradually diversified into employing technologies such as thermal reduction,MSE,and titanium alloy preparation.This study provides a comprehensive review of research advances in titanium metal preparation technologies over the past two decades,highlighting the challenges faced by the existing methods and proposing potential solutions.It offers useful insights into the development of low-cost titanium preparation technologies.
基金supported by the National Key R&D Program of China(No.2024YFB4206700)the Joint Geological Funds of the National Natural Science Foundation of China(No.U2244223)+5 种基金the China Scholarship Council Program(No.202404910533)the Guangdong Major Project of Basic and Applied Basic Research(No.2020B0301030003)the China Geological Survey Project(No.DD20211350)the Key Deployment Program of Chinese Academy of Sciences(Nos.YJKYYQ20190043,ZDBS-LY-DQC003,KFZD-SW-422,and ZDRW-ZS-2021-3-1)the Scientific Research and Technology Development Project of China National Petroleum Corporation(No.2022DJ5503)the Supercomputing Laboratory,IGGCAS.
文摘This study proposes and systematically evaluates an optimized integration of warm surface seawater injection with depressurization for the long-term exploitation of marine natural gas hydrates.By employing comprehensive multiphysics simulations guided by field data from hydrate production tests in the South China Sea,we pinpoint key operational parameters—such as injection rates,depths,and timings—that notably enhance production efficiency.The results indicate that a 3-phase hydrate reservoir transitions from a free-gas-dominated production stage to a hydrate-decomposition-dominated stage.Moderate warm seawater injection supplies additional heat during the hydrate decomposition phase,thereby enhancing stable production;however,excessively high injection rates can impede the depressurization process.Only injection at an appropriate depth simultaneously balances thermal supplementation and the pressure gradient,leading to higher overall productivity.A“depressurization-driven sensible-heat supply window”is introduced,highlighting that timely seawater injection following initial depressurization prolongs reservoir dissociation dynamics.In this study area,commencing seawater injection at 170 d of depressurization proved optimal.This optimized integration leverages clean and renewable thermal energy,providing essential insights into thermal supplementation strategies with significant implications for sustainable,economically feasible,and efficient commercial-scale hydrate production.
基金Supported by Japan Society for the Promotion of Science,No.24K11935.
文摘This review comprehensively summarized the potential of artificial intelligence(AI)in the management of esophageal cancer.It highlighted the significance of AI-assisted endoscopy in Japan where endoscopy is central to both screening and diagnosis.For the clinical adaptation of AI,several challenges remain for its effective translation.The establishment of high-quality clinical databases,such as the National Clinical Database and Japan Endoscopy Database in Japan,which covers almost all cases of esophageal cancer,is essential for validating multimodal AI models.This requires rigorous external validation using diverse datasets,including those from different endoscope manufacturers and image qualities.Furthermore,endoscopists’skills significantly affect diagnostic accuracy,suggesting that AI should serve as a supportive tool rather than a replacement.Addressing these challenges,along with country-specific legal and ethical considerations,will facilitate the successful integration of multimodal AI into the management of esophageal cancer,particularly in endoscopic diagnosis,and contribute to improved patient outcomes.Although this review focused on Japan as a case study,the challenges and solutions described are broadly applicable to other high-incidence regions.
基金Supported by Quebec Health Research Fund Clinician Research Scholars Junior 1,No.350546.
文摘Clinically significant Portal hypertension(PH),defined by a hepatic venous pressure gradient(HVPG)greater than 10 mmHg,is a key predictor of decompensation events in cirrhosis,leading to variceal hemorrhage,ascites,and hepatic encephalopathy.This narrative review explores the pathophysiology of PH in cirrhosis,evaluates diagnostic methods for identifying clinically significant PH(CSPH),and discusses guideline-driven strategies to prevent initial and further decompensation.While HVPG remains the gold standard for diagnosing CSPH,non-invasive tools such as liver stiffness measurement and spleen stiffness measurement are increasingly used for initial risk stratification.The combined use of these tools reduces the proportion of patients in the diagnostic"grey zone".Endoscopic ultrasound-guided portal pressure gradient is an emerging diagnostic tool that requires further validation.Non-selective beta-blockers are the cornerstone of primary prophylaxis for decompensation,and their combination with endoscopic variceal ligation is the first-line therapy for secondary prophylaxis of recurrent esophageal variceal bleeding.Statins show promise in reducing PH and preventing decompensation while further studies are still needed.This review also discusses the indications for preemptive transjugular intrahepatic portosystemic shunt and its role in managing refractory ascites and variceal bleeding.
文摘Dear Editor,I am responding to Zou and Li's,The missing perilymph sign on MRI indicates a perilymphatic fistula:A case report Zou J,Li H.Journal of Otology,2025, 20(1):1-4.https://doi.org/10.26599/JOTO.2025.9540001 proposing the"missing perilymph"sign on MRI as a novel radiological indicator of perilymphatic fistula(PLF).This study adds to the growing body of work seeking objective,non-invasive diagnostic methods for PLF,a condition that has long eluded definitive radiological confirmation.The avoidance of gadolinium contrast in the imaging technique is an additional strength,given increasing awareness of gadoliniumassociated risks (Starekova et al.,2024).
文摘Urethral catheterization is an important skill to develop as consultations for“difficult catheterization”are common in practice.Developing a broad approach to difficult urethral catheterization is crucial to improve trainee success rates.Strategies and techniques to improve catheterization success are often passed down and shared between trainees without formal documentation or dissemination of techniques.Herein,we present a framework for difficult urethral catheterization based on clinical history and patient examination,while also providing additional techniques and troubleshooting to overcome common challenges with urethral catheterization in adult and pediatric patients.
文摘Lymphedema,particularly in its advanced stages,presents significant challenges in treatment,often necessitating a combination of therapies to manage symptoms effectively and improve patient outcomes.This article reviews the findings of Wang et al,regarding the use of lymphovenous anastomosis and complex decongestive therapy in treating severe,deformed stage III lymphedema with recurrent infections.The case report details the promising results achieved through this combined therapy,highlighting substantial reductions in limb volume and the complete resolution of recurrent lymphangitis.The patient experienced notable improvements in weight loss,physical function,and quality of life.Despite its strengths,the study has several limitations.It lacks specific details on the types of lymphovenous anastomoses performed and complex decongestive therapy protocols,such as frequency and adherence,making reproducibility difficult.The short follow-up period of six months limits understanding of long-term efficacy,and more consistent reporting of key metrics such as weight loss and body mass index would enhance outcome assessments.This article emphasizes the importance of integrating minimally invasive surgical techniques with conservative therapies to address both the symptoms and underlying causes of lymphedema.Further research is essential to standardize protocols and refine combined treatment strategies.
文摘BACKGROUND Second-line treatment of Crohn’s disease(CD)commonly involves immunosuppressants such as azathioprine,mercaptopurine,or methotrexate(MTX),used either alone or in combination.AIM To investigate the current use of MTX among French gastroenterologists.METHODS An online questionnaire was distributed between March and August 2023 to 116 French gastroenterologists managing CD.A total of 87 respondents completed the survey and were included in the analysis.RESULTS Respondents reported a mean annual caseload of 140 CD patients(median:50).Overall,71%prescribed MTX,predominantly in injectable form(92%),either as monotherapy or in combination with biologics or cyclosporin.MTX was prescribed for mild-to-moderate CD by 64%of respondents,and for severe CD by 58%,often in combination with an anti-tumor necrosis factor agent(89%and 94%,respectively).Injectable MTX was favored(84%)in specific clinical scenarios:Patients with articular manifestations(77%),Epstein-Barr virus-negative status(65%),or aged over 65 years(58%).Among the 29%of non-prescribers,the primary reason cited was lack of familiarity with MTX use(60%).Both prescribers and non-prescribers expressed the need for clearer guidelines and real-world data to support MTX use.CONCLUSION Regardless of prescribing habits,most respondents had a favorable opinion of MTX and recognized its good longterm safety profile.French learned societies and medical associations should provide consensus guidelines on MTX use,supported by validated real-world safety and effectiveness data.
基金the Deanship of Research and Graduate Studies at King Khalid University,KSA,for funding this work through the Large Research Project under grant number RGP2/164/46.
文摘Background:Stomach cancer(SC)is one of the most lethal malignancies worldwide due to late-stage diagnosis and limited treatment.The transcriptomic,epigenomic,and proteomic,etc.,omics datasets generated by high-throughput sequencing technology have become prominent in biomedical research,and they reveal molecular aspects of cancer diagnosis and therapy.Despite the development of advanced sequencing technology,the presence of high-dimensionality in multi-omics data makes it challenging to interpret the data.Methods:In this study,we introduce RankXLAN,an explainable ensemble-based multi-omics framework that integrates feature selection(FS),ensemble learning,bioinformatics,and in-silico validation for robust biomarker detection,potential therapeutic drug-repurposing candidates’identification,and classification of SC.To enhance the interpretability of the model,we incorporated explainable artificial intelligence(SHapley Additive exPlanations analysis),as well as accuracy,precision,F1-score,recall,cross-validation,specificity,likelihood ratio(LR)+,LR−,and Youden index results.Results:The experimental results showed that the top four FS algorithms achieved improved results when applied to the ensemble learning classification model.The proposed ensemble model produced an area under the curve(AUC)score of 0.994 for gene expression,0.97 for methylation,and 0.96 for miRNA expression data.Through the integration of bioinformatics and ML approach of the transcriptomic and epigenomic multi-omics dataset,we identified potential marker genes,namely,UBE2D2,HPCAL4,IGHA1,DPT,and FN3K.In-silico molecular docking revealed a strong binding affinity between ANKRD13C and the FDA-approved drug Everolimus(binding affinity−10.1 kcal/mol),identifying ANKRD13C as a potential therapeutic drug-repurposing target for SC.Conclusion:The proposed framework RankXLAN outperforms other existing frameworks for serum biomarker identification,therapeutic target identification,and SC classification with multi-omics datasets.
基金supported by funding from the Veterans Administration(I01 BX006101-01)supported in part by funding from the Veterans Administration(IO1 BX001262)the recipient of RCS Award(IK6 BX005964)from the Department of Veterans Administration.
文摘Fc Receptor-Like 1(FCRL1),a member of the FCRL family,contains two immunoreceptor tyrosinebased activation motifs(ITAMs)in its cytoplasmic domain and plays a critical role in B-cell biology.Its expression begins in pre-B-cells,dynamically shifts during B-cell development,and contributes to the regulation of human B-cell activation.Notably,FCRL1 is overexpressed in subsets of naive and memory B-cells,as well as in malignant B-cells,including those in diffuse large B-cell lymphoma(DLBCL),an aggressive and often treatment-resistant hematological malignancy.Among FCRL family members,FCRL1 stands out as a promising immunotherapeutic target due to its selective expression in malignant B-cells and its functional role in proliferation.Given the limited efficacy of current therapies for relapsed/refractory DLBCL,targeting FCRL1 could address an unmet clinical need by offering a novel,mechanism-based approach to modulate B-cell signaling and enhance anti-tumor immunity.This mini-review highlights the therapeutic potential of FCRL1-directed strategies,supporting their further exploration in preclinical models and future clinical trials for DLBCL and other B-cell malignancies.
文摘This special issue of iRADIOLOGY on the application of in-struments and equipment in medical imaging documents the groundbreaking strides to develop optimal imaging modalities,particularly X‐ray,ultrasound,computed tomography(CT),magnetic resonance imaging(MRI),positron emission tomog-raphy(PET),and single‐photon emission computed tomography(SPECT),to diagnose,treat,cure,and ultimately prevent med-ical disorders.This special issue continues the outstanding contributions of prior special issues on ultra‐high field MRI[1],ultra‐high field MRI in the theranostics of mental disorders[2],artificial intelligence in medical imaging[3],imaging of fetuses,children,and mothers[4],and the use of large language models in radiology[5]to provide readers updates on the state‐of‐the‐art of the application of instruments and equipment in medi-cal imaging to utilize the promising hardware available for optimal interventions in medicine.
基金sponsored by the National Science Foundation of China(Nos.52200189,52230006,and 32271700)the Guangxi Science and Technology Project,China(Nos.2021GXNSFBA220055,2020GXNSFAA297256,and Guike AB21220049)+2 种基金the Guangxi Key Laboratory of Environmental Pollution Control Theory and TechnologyGuangxi Engineering Research Center of Comprehensive Treatment for Agricultural Non-Point Source PollutionModern Industry College of Ecology and Environmental Protection from Guilin University of Technology,China for support。
文摘To promote growth,terrestrial plants release photosynthetic products into the rhizosphere in the form of root exudates through their root systems.Under the attraction of root exudates,plant growth-promoting rhizobacteria(PGPR)colonize the rhizosphere to stimulate plant growth and/or suppress the growth of pathogenic microorganisms.The rhizospheric recruitment of PGPR,as well as the establishment of root-microbe interactions,is initiated by chemotaxis towards root exudates.Over the past several decades,scientists have made notable strides in identifying representative chemoeffectors in root exudates,as well as the corresponding chemoreceptors.We review here the most recent developments in rhizospheric chemotaxis,particularly the chemoeffectors in root exudates,the structural and functional characterization of methyl-accepting chemotaxis proteins of PGPR,and the impacts of rhizospheric chemotaxis on root colonization,biofilm formation,and other root-microbe interactions during recruitment.Finally,we propose several perspectives that aim to fully unlock the potential of PGPR as bioinoculants in sustainable agriculture.
