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Emerging trends and perspectives for biomedical engineering
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作者 Hong-Hao Hou 《Biomedical Engineering Communications》 2025年第1期1-2,共2页
Welcome to the 4th volume of Biomedical Engineering Communications the first issue of 2025!Biomedical engineering is a rapidly evolving field that combines engineering principles with medical and biological sciences t... Welcome to the 4th volume of Biomedical Engineering Communications the first issue of 2025!Biomedical engineering is a rapidly evolving field that combines engineering principles with medical and biological sciences to create innovative healthcare technologies.Biomedical engineering brings an interdisciplinary,problem-solving approach to bioengineering,biology and medicine.This interdisciplinary field is essential for developing advanced medical devices,diagnostic tools,and therapeutic solutions that enhance patient care and improve health outcomes.It allows them to develop technologies and systems that directly contribute to diagnosing,treating and preventing diseases. 展开更多
关键词 combines engineering principles biomedical engineering emerging trends advanced medical devicesdiagnostic healthcare technologies interdisciplinary approach medical biological sciences BIOENGINEERING
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Quality Assurance and Evaluation of Software Engineering Education in China and Europe:Theoretical Framework and Practical Pathways
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作者 Jianguo Chen Mingzhi Mao +2 位作者 Xiangyuan Zhu Qingzhen Xu Zibin Zheng 《计算机教育》 2025年第3期145-155,共11页
With the rapid advancement of information technology,the quality assurance and evaluation of software engineering education have become pivotal concerns for higher education institutions.In this paper,we focus on a co... With the rapid advancement of information technology,the quality assurance and evaluation of software engineering education have become pivotal concerns for higher education institutions.In this paper,we focus on a comparative study of software engineering education in China and Europe,aiming to explore the theoretical frameworks and practical pathways employed in both regions.Initially,we introduce and contrast the engineering education accreditation systems of China and Europe,including the Chinese engineering education accreditation framework and the European EUR-ACE(European Accreditation of Engineering Programmes)standards,highlighting their core principles and evaluation methodologies.Subsequently,we provide case studies of several universities in China and Europe,such as Sun Yat-sen University,Tsinghua University,Technical University of Munich,and Imperial College London.Finally,we offer recommendations to foster mutual learning and collaboration between Chinese and European institutions,aiming to enhance the overall quality of software engineering education globally.This work provides valuable insights for educational administrators,faculty members,and policymakers,contributing to the ongoing improvement and innovative development of software engineering education in China and Europe. 展开更多
关键词 Software engineering education Quality assurance and evaluation Chinese engineering education accreditation European accreditation of engineering programmes
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Integrating Main-Chain and Side-Chain Engineering in Polymers for Enhanced Photocatalytic Hydrogen Production
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作者 TIAN Changhao LIU Xueyan +4 位作者 YU Miaojie WU Yongzhen CHE Yu ZHANG Weiwei ZHU Weihong 《功能高分子学报》 北大核心 2025年第3期216-227,共12页
Traditional polymeric photocatalysts are typically constructed using aromatic building blocks to enhanceπ-conjugation.However,their inherent hydrophobicity and rigid structure lead to poor dispersibility in aqueous s... Traditional polymeric photocatalysts are typically constructed using aromatic building blocks to enhanceπ-conjugation.However,their inherent hydrophobicity and rigid structure lead to poor dispersibility in aqueous solutions,resulting in significant optical losses and exciton recombination.In this study,two series of six novel polymer photocatalysts(FLUSO,FLUSO-PEG10,FLUSO-PEG30;CPDTSO,CPDTSO-PEG10,CPDTSO-PEG30)are designed and synthesized by incorporating the hydrophilic,non-conjugated polyethylene glycol(PEG)chain,into both the main and side chains of polymers.By precisely optimizing the ratio of hydrophilic PEG segments,the water dispersibility is significantly improved while the light absorption capability of the polymer photocatalysts is well maintained.The experimental results confirm that the optimized FLUSO-PEG10 exhibits excellent photocatalytic hydrogen evolution rate,reaching up to 33.9 mmol/(g·h),which is nearly three times higher than that of fullyπ-conjugated counterparts.Water contact angles and particle size analyses reveal that incorporating non-conjugated segments into the main chains enhances the capacitance of the polymer/water interface and reduces particle aggregation,leading to improved photocatalyst dispersion and enhanced charge generation. 展开更多
关键词 organic semiconductor polymer photocatalyst main-chain engineering side-chain engineering photocatalytic hydrogen evolution
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Geographical Engineering and Its Role in Promoting Integrated Geography Research 被引量:1
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作者 LIU Yansui SU Sixin LI Xuhong 《Chinese Geographical Science》 2025年第1期1-23,共23页
Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orien... Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies. 展开更多
关键词 geographical engineering geographical science and engineering integrated geography research human-earth system Chinese geography
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Reform and Practice of Digital Platform-assisted Teaching in Molecular Biology under the Background of Engineering Education Accreditation
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作者 Li HAO Aidong QIU +3 位作者 Xiaohong HU Yan WAN Min LI Yanxia SUN 《Agricultural Biotechnology》 2025年第4期81-83,87,共4页
Under the background of the continuous deepening of engineering education accreditation and the construction of emerging engineering disciplines,a digital platform-assisted teaching model was explored for the teaching... Under the background of the continuous deepening of engineering education accreditation and the construction of emerging engineering disciplines,a digital platform-assisted teaching model was explored for the teaching reform of the molecular biology course to effectively support the achievement of graduation requirements for bioengineering major and enhance the teaching outcomes of the molecular biology course.The teaching reform of this course took the 2022 cohort students majoring in bioengineering in Chengdu University as the practice object.The course evaluation method was improved by integrating digital platforms for process assessment,and real-world research and practical cases were incorporated into digital platforms to enrich teaching resources.Additionally,digital platforms were integrated throughout the entire teaching process(before,during,and after class),reshaping the instructional workflow into"pre-class online self-learning,in-class teacher-student interaction for deepening knowledge internalization,and practical case studies during and after class for strengthening application".The teaching reform results demonstrated that this teaching model significantly improved the attainment of course objectives,providing valuable experience for similar institutions to advance digital course reforms under the framework of engineering education accreditation. 展开更多
关键词 Engineering education accreditation Digital platform Molecular biology BIOENGINEERING Teaching reform
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Large Language Models in Software Engineering Education: A Preliminary Study on Software Requirements Engineering Courses
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作者 Feng Chen Shaomin Zhu +1 位作者 Xin Liu Ying Qian 《计算机教育》 2025年第3期24-33,共10页
The advent of large language models(LLMs)has made knowledge acquisition and content creation increasingly easier and cheaper,which in turn redefines learning and urges transformation in software engineering education.... The advent of large language models(LLMs)has made knowledge acquisition and content creation increasingly easier and cheaper,which in turn redefines learning and urges transformation in software engineering education.To do so,there is a need to understand the impact of LLMs on software engineering education.In this paper,we conducted a preliminary case study on three software requirements engineering classes where students are allowed to use LLMs to assist in their projects.Based on the students’experience,performance,and feedback from a survey conducted at the end of the courses,we characterized the challenges and benefits of applying LLMs in software engineering education.This research contributes to the ongoing discourse on the integration of LLMs in education,emphasizing both their prominent potential and the need for balanced,mindful usage. 展开更多
关键词 Large language models Software engineering Software requirements engineering EDUCATION
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Teaching Reform of Environmental Engineering Microbiology Based on OBE Concept in the Context of New Engineering Disciplines
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作者 Shasha LIU Jinhuan DENG Weixiong LIN 《Asian Agricultural Research》 2025年第1期41-43,共3页
In response to meeting the needs of cultivating applied talents in the construction of new engineering disciplines,based on the concept of Outcome-Based Education(OBE),this study analyzes the problems existing in the ... In response to meeting the needs of cultivating applied talents in the construction of new engineering disciplines,based on the concept of Outcome-Based Education(OBE),this study analyzes the problems existing in the teaching of the course Environmental Engineering Microbiology,and put forward some corresponding curriculum reform schemes.According to the target points of professional graduation requirements,the scheme proposes revising the syllabus of Environmental Engineering Microbiology,clarifying the curriculum objectives,updating the teaching content,and reforming the teaching methods.Through these measures,it is intended to achieve the unity of teachers way of"teaching"and students way of"learning",construct a new teaching mode,fully stimulate students subjective initiative,and enhance students innovative consciousness and practical ability.Besides,in this study,a"whole process-diversification"evaluation system is established to comprehensively evaluate students performance in theoretical knowledge learning and practical application,comprehensively evaluate students learning situation,and analyze the teaching effect in real time,so as to achieve continuous improvement,and ultimately achieve the goal of improving classroom quality. 展开更多
关键词 New engineering disciplines Outcome-Based Education(OBE)concept Environmental Engineering Microbiology
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Advancements in Laboratory Studies of Layered Rock Masses for Deep Engineering:Insights and Future Perspectives
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作者 Yan Zhang Kai Meng +6 位作者 Xuanmei Fan Guoqing Chen Xiangsheng Zheng Shaojun Li Tianbin Li Peng Zeng Min Xia 《Journal of Earth Science》 2025年第3期1334-1340,共7页
Layered rock masses represent complex geological formations commonly encountered in the surrounding rock of deep engineering excavations(Hou et al.,2019;Xu et al.,2017;Yang C H et al.,2009;Xian and Tan,1989).These roc... Layered rock masses represent complex geological formations commonly encountered in the surrounding rock of deep engineering excavations(Hou et al.,2019;Xu et al.,2017;Yang C H et al.,2009;Xian and Tan,1989).These rock masses are predominantly composed of sedimentary,para-metamorphic,and volcanic rock types,characterized by a set of prominent,primary bedding structural planes(layers)exhibiting relatively consistent orientations and significant spatial continuity. 展开更多
关键词 surrounding rock rock masses deep engineering laboratory studies geological formations layered rock masses sedimentary rocks deep engineering excavations hou
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Smart Techniques Promoting Sustainability in Construction Engineering and Management 被引量:1
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作者 Song-Shun Lin Shui-Long Shen +1 位作者 Annan Zhou Xiang-Sheng Chen 《Engineering》 2025年第2期262-282,共21页
Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.T... Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.To contribute to a better understanding of the state of the art of smart techniques for engineering projects,this paper provides a comprehensive review of multi-criteria decision-making(MCDM)techniques,intelligent techniques,and their applications in CEM.First,a comprehensive framework detailing smart technologies for construction projects is developed.Next,the characteristics of CEM are summarized.A bibliometric review is then conducted to investigate the keywords,journals,and clusters related to the application of smart techniques in CEM during 2000-2022.Recent advancements in intelligent techniques are also discussed under the following six topics:①big data technology;②computer vision;③speech recognition;④natural language processing;⑤machine learning;and⑥knowledge representation,understanding,and reasoning.The applications of smart techniques are then illustrated via underground space exploitation.Finally,future research directions for the sustainable development of smart construction are highlighted. 展开更多
关键词 Construction engineering and management Multi-criteria decision-making techniques Intelligent techniques Digital transformation SUSTAINABILITY
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Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion
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作者 Wei Ma Jiahao Yao +6 位作者 Fang Xie Xinqi Wang Hao Wan Xiangjian Shen Lili Zhang Menggai Jiao Zhen Zhou 《Green Energy & Environment》 SCIE EI CAS 2025年第1期109-131,共23页
Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic efficiency.The introduction of defects emerges as a promising strategy,effectively modifying the e... Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic efficiency.The introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active sites.This optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of electrocatalysts.To elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization techniques.Importantly,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/N_(2) reduction reactions by integrating mechanisms from diverse reactions.This underscores the pivotal role of point defects in enhancing catalytic performance.At last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials. 展开更多
关键词 Point defect engineering DOPING VACANCY ELECTROCATALYSIS Electronic structure
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Defect Engineering:Can it Mitigate Strong Coulomb Effect of Mg^(2+)in Cathode Materials for Rechargeable Magnesium Batteries?
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作者 Zhengqing Fan Ruimin Li +3 位作者 Xin Zhang Wanyu Zhao Zhenghui Pan Xiaowei Yang 《Nano-Micro Letters》 SCIE EI CAS 2025年第1期135-159,共25页
Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage market.However,th... Rechargeable magnesium batteries(RMBs)have been considered a promising“post lithium-ion battery”system to meet the rapidly increasing demand of the emerging electric vehicle and grid energy storage market.However,the sluggish diffusion kinetics of bivalent Mg^(2+)in the host material,related to the strong Coulomb effect between Mg^(2+)and host anion lattices,hinders their further development toward practical applications.Defect engineering,regarded as an effective strategy to break through the slow migration puzzle,has been validated in various cathode materials for RMBs.In this review,we first thoroughly understand the intrinsic mechanism of Mg^(2+)diffusion in cathode materials,from which the key factors affecting ion diffusion are further presented.Then,the positive effects of purposely introduced defects,including vacancy and doping,and the corresponding strategies for introducing various defects are discussed.The applications of defect engineering in cathode materials for RMBs with advanced electrochemical properties are also summarized.Finally,the existing challenges and future perspectives of defect engineering in cathode materials for the overall high-performance RMBs are described. 展开更多
关键词 Rechargeable magnesium battery Sluggish diffusion kinetic Defect engineering Cathode materials Ion migration
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Artificial Intelligence-Enhanced Digital Twin Systems Engineering Towards the Industrial Metaverse in the Era of Industry 5.0 被引量:3
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作者 He Zhang Yilin Li +2 位作者 Shuai Zhang Lukai Song Fei Tao 《Chinese Journal of Mechanical Engineering》 2025年第2期98-119,共22页
With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenu... With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE. 展开更多
关键词 Digital twins Systems engineering Industrial metaverse Artificial intelligence Industry 5.0 Smart manufacturing
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Research progress of intelligent testing technology and evaluation methods for subgrade engineering 被引量:1
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作者 Guojun Cai Hongliang Tian +2 位作者 Lulu Liu Xiaoyan Liu Songyu Liu 《Journal of Road Engineering》 2025年第2期164-183,共20页
Subgrade engineering is a fundamental aspect of infrastructure construction in China.As the primary structural element responsible for bearing and distributing traffic loads,the subgrade must not only withstand the su... Subgrade engineering is a fundamental aspect of infrastructure construction in China.As the primary structural element responsible for bearing and distributing traffic loads,the subgrade must not only withstand the substantial pressures exerted by vehicles,trains,and other forms of transportation,but also efficiently transfer these loads to the underlying foundation,ensuring the stability and longevity of the roadway.In recent years,advancements in subgrade engineering technology have propelled the industry towards smarter,greener,and more sustainable practices,particularly in the areas of intelligent monitoring,disaster management,and innovative construction methods.This paper reviews the application and methodologies of intelligent testing equipment,including cone penetration testing(CPT)devices,soil resistivity testers,and intelligent rebound testers,in subgrade engineering.It examines the operating principles,advantages,limitations,and application ranges of these tools in subgrade testing.Additionally,the paper evaluates the practical use of advanced equipment from both domestic and international perspectives,addressing the challenges encountered by various instruments in realworld applications.These devices enable precise,comprehensive testing and evaluation of subgrade conditions at different stages,providing real-time data analysis and intelligent early warnings.This supports effective subgrade health management and maintenance.As intelligent technologies continue to evolve and integrate,these tools will increasingly enhance the accuracy,efficiency,and sustainability of subgrade monitoring. 展开更多
关键词 Subgrade engineering Intelligent testing technology Technology evaluation Health management and maintenance
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Defect Engineering with Rational Dopants Modulation for High‑Temperature Energy Harvesting in Lead‑Free Piezoceramics
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作者 Kaibiao Xi Jianzhe Guo +2 位作者 Mupeng Zheng Mankang Zhu Yudong Hou 《Nano-Micro Letters》 SCIE EI CAS 2025年第3期87-101,共15页
High temperature piezoelectric energy harvester(HTPEH)is an important solution to replace chemical battery to achieve independent power supply of HT wireless sensors.However,simultaneously excellent performances,inclu... High temperature piezoelectric energy harvester(HTPEH)is an important solution to replace chemical battery to achieve independent power supply of HT wireless sensors.However,simultaneously excellent performances,including high figure of merit(FOM),insulation resistivity(ρ)and depolarization temperature(Td)are indispensable but hard to achieve in lead-free piezoceramics,especially operating at 250°C has not been reported before.Herein,well-balanced performances are achieved in BiFeO3–BaTiO3 ceramics via innovative defect engineering with respect to delicate manganese doping.Due to the synergistic effect of enhancing electrostrictive coefficient by polarization configuration optimization,regulating iron ion oxidation state by high valence manganese ion and stabilizing domain orientation by defect dipole,comprehensive excellent electrical performances(Td=340°C,ρ250°C>10^(7)Ωcm and FOM_(250°C)=4905×10^(–15)m^(2)N^(−1))are realized at the solid solubility limit of manganese ions.The HT-PEHs assembled using the rationally designed piezoceramic can allow for fast charging of commercial electrolytic capacitor at 250°C with high energy conversion efficiency(η=11.43%).These characteristics demonstrate that defect engineering tailored BF-BT can satisfy high-end HT-PEHs requirements,paving a new way in developing selfpowered wireless sensors working in HT environments. 展开更多
关键词 Lead-free piezoceramic Defect engineering Dopants modulation High-temperature Piezoelectric energy harvester
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Enhanced Piezoelectric Properties of (1-x)(0.8PZT-0.2PZN)-xBZT Ceramics via Phase Boundary and Domain Engineering
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作者 CHEN Xiangjie LI Ling +2 位作者 LEI Tianfu WANG Jiajia WANG Yaojin 《无机材料学报》 北大核心 2025年第6期729-734,共6页
Pb(Zr,Ti)O_(3)-Pb(Zn_(1/3)Nb_(2/3))O_(3) (PZT-PZN) based ceramics, as important piezoelectric materials, have a wide range of applications in fields such as sensors and actuators, thus the optimization of their piezoe... Pb(Zr,Ti)O_(3)-Pb(Zn_(1/3)Nb_(2/3))O_(3) (PZT-PZN) based ceramics, as important piezoelectric materials, have a wide range of applications in fields such as sensors and actuators, thus the optimization of their piezoelectric properties has been a hot research topic. This study investigated the effects of phase boundary engineering and domain engineering on (1-x)[0.8Pb(Zr_(0.5)Ti_(0.5))O_(3)-0.2Pb(Zn_(1/3)Nb_(2/3))O_(3)]-xBi(Zn_(0.5)Ti_(0.5))O_(3) ((1-x)(0.8PZT-0.2PZN)- xBZT) ceramic to obtain excellent piezoelectric properties. The crystal phase structure and microstructure of ceramic samples were characterized. The results showed that all samples had a pure perovskite structure, and the addition of BZT gradually increased the grain size. The addition of BZT caused a phase transition in ceramic samples from the morphotropic phase boundary (MPB) towards the tetragonal phase region, which is crucial for optimizing piezoelectric properties. By adjusting content of BZT and precisely controlling position of the phase boundary, the piezoelectric performance can be optimized. Domain structure is one of the key factors affecting piezoelectric performance. By using domain engineering techniques to optimize grain size and domain size, piezoelectric properties of ceramic samples have been significantly improved. Specifically, excellent piezoelectric properties (piezoelectric constant d_(33)=320 pC/N, electromechanical coupling factor kp=0.44) were obtained simultaneously for x=0.08. Based on experimental results and theoretical analysis, influence mechanisms of phase boundary engineering and domain engineering on piezoelectric properties were explored. The study shows that addition of BZT not only promotes grain growth, but also optimizes the domain structure, enabling the polarization reversal process easier, thereby improving piezoelectric properties. These research results not only provide new ideas for the design of high-performance piezoelectric ceramics, but also lay a theoretical foundation for development of related electronic devices. 展开更多
关键词 phase boundary 0.8PZT-0.2PZN domain engineering piezoelectric property
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Recent advances in interfacial engineering for high-efficiency perovskite photovoltaics 被引量:1
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作者 Zhijie Wang Cheng Gong +4 位作者 Cong Zhang Chenxu Zhao Tzu-Sen Su Haiyun Li Hong Zhang 《DeCarbon》 2025年第2期10-23,共14页
Through strategies such as process optimization,solvent selection,and component tuning,the crystallization of perovskite materials has been effectively controlled,enabling perovskite solar cells(PSCs)to achieve over 2... Through strategies such as process optimization,solvent selection,and component tuning,the crystallization of perovskite materials has been effectively controlled,enabling perovskite solar cells(PSCs)to achieve over 25%power conversion efficiency(PCE).However,as PCE continues to improve,interfacial issues within the devices have emerged as critical bottlenecks,hindering further performance enhancements.Recently,interfacial engineering has driven transformative progress,pushing PCEs to nearly 27%.Building upon these developments,this review first summarizes the pivotal role of interfacial modifications in elevating device performance and then,as a starting point,provides a comprehensive overview of recent advancements in normal,inverted,and tandem structure devices.Finally,based on the current progress of PSCs,preliminary perspectives on future directions are presented. 展开更多
关键词 Perovskite solar cells Interfacial engineering Defect passivation Energy level alignment Ion migration Device stability
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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery 被引量:1
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作者 Jiali Chen Yiyang Li +7 位作者 Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao 《Neural Regeneration Research》 SCIE CAS 2025年第8期2181-2198,共18页
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc... Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy. 展开更多
关键词 delivery engineering extracellular vesicles identification ischemic stroke isolation MITOCHONDRIA targeting strategy therapeutic effects
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A unique bioreactor that offers synchronized physiological-like electrical and mechanical stimuli for cardiac tissue engineering
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作者 Maskit Gvirtz Markish Udi Sarig +1 位作者 Limor Baruch Marcelle Machluf 《Bio-Design and Manufacturing》 2025年第4期581-594,I0031,I0032,共16页
Cardiac tissue engineering aims to efficiently replace or repair injured heart tissue using scaffolds,relevant cells,or their combination.While the combination of scaffolds and relevant cells holds the potential to ra... Cardiac tissue engineering aims to efficiently replace or repair injured heart tissue using scaffolds,relevant cells,or their combination.While the combination of scaffolds and relevant cells holds the potential to rapidly remuscularize the heart,thereby avoiding the slow process of cell recruitment,the proper ex vivo cellularization of a scaffold poses a substantial challenge.First,proper diffusion of nutrients and oxygen should be provided to the cell-seeded scaffold.Second,to generate a functional tissue construct,cells can benefit from physiological-like conditions.To meet these challenges,we developed a modular bioreactor for the dynamic cellularization of full-thickness cardiac scaffolds under synchronized mechanical and electrical stimuli.In this unique bioreactor system,we designed a cyclic mechanical load that mimics the left ventricle volume inflation,thus achieving a steady stimulus,as well as an electrical stimulus with an action potential profile to mirror the cells’microenvironment and electrical stimuli in the heart.These mechanical and electrical stimuli were synchronized according to cardiac physiology and regulated by constant feedback.When applied to a seeded thick porcine cardiac extracellular matrix(pcECM)scaffold,these stimuli improved the proliferation of mesenchymal stem/stromal cells(MSCs)and induced the formation of a dense tissue-like structure near the scaffold’s surface.Most importantly,after 35 d of cultivation,the MSCs presented the early cardiac progenitor markers Connexin-43 andα-actinin,which were absent in the control cells.Overall,this research developed a new bioreactor system for cellularizing cardiac scaffolds under cardiac-like conditions,aiming to restore a sustainable dynamic living tissue that can bear the essential cardiac excitation–contraction coupling. 展开更多
关键词 Tissue engineering BIOREACTOR Mechanical stimulation Electrical stimulation PERFUSION Excitation-contraction coupling Cardiac regeneration
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Effect of Image Resolution on UAV-Based Photogrammetric Accuracy for Civil Engineering Applications
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作者 Mostafa Abdel-Bary Ebrahim 《Journal of Civil Engineering and Architecture》 2025年第7期317-326,共10页
This study provides the first systematic evaluation of image resolution’s effect (50-300 PPI, pixels per inch) on UAV (unmanned aerial vehicle)-based digital close-range photogrammetry accuracy in civil engineering a... This study provides the first systematic evaluation of image resolution’s effect (50-300 PPI, pixels per inch) on UAV (unmanned aerial vehicle)-based digital close-range photogrammetry accuracy in civil engineering applications, such as infrastructure monitoring and heritage preservation. Using a high-resolution UAV with a 20 MP (MegaPixels) sensor, four images of a brick wall test field were captured and processed in Agisoft Metashape, with resolutions compared against Leica T2002 theodolite measurements (1.0 mm accuracy). Advanced statistical methods (ANOVA (analysis of variance), Tukey tests, Monte Carlo simulations) and ground control points validated the results. Accuracy improved from 25 mm at 50 PPI to 5 mm at 150 PPI (p < 0.01), plateauing at 4 mm beyond 200 PPI, while 150 PPI reduced processing time by 62% compared to 300 PPI. Unlike prior studies, this research uniquely isolates resolution effects in a controlled civil engineering context, offering a novel 150 PPI threshold that balances precision and efficiency. This threshold supports Saudi Vision 2030’s smart infrastructure goals for megaprojects like NEOM, providing a scalable framework for global applications. Future research should leverage deep learning to optimize resolutions in dynamic environments. 展开更多
关键词 UAV photogrammetry image resolution 3D measurements civil engineering Saudi Vision 2030
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Kinked Rebar and Engineering Structures Applying Kinked Materials:State-ofthe-Art Review
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作者 Chengquan Wang Lei Xu +4 位作者 Xinquan Wang Yun Zou Kangyu Wang Boyan Ping Xiao Li 《Structural Durability & Health Monitoring》 2025年第2期233-263,共31页
Kinked rebar is a special type of steel material,which is installed in beam column nodes and frame beams.It effectively enhances the blast resilience,seismic collapse resistance,and progressive collapse resistance of ... Kinked rebar is a special type of steel material,which is installed in beam column nodes and frame beams.It effectively enhances the blast resilience,seismic collapse resistance,and progressive collapse resistance of reinforced concrete(RC)structures without imposing substantial cost burdens,thereby emerging as a focal point of recent research endeavors.On the basis of explaining the working principle of kinked rebars,this paper reviews the research status of kinked rebars at home and abroad from three core domains:the tensile mechanical properties of kinked rebars,beam column nodes with kinked rebars,and concrete frame structures with kinked rebars.The analysis underscores that the straightening process of kinked rebars does not compromise their ultimate strength but significantly bolsters structural ductility and enhances energy dissipation capabilities.In beam-column joints,the incorporation of kinked rebars facilitates the seamless transfer of plastic hinges,adhering to the design principle of“strong columns and weak beams.”In addition,kinked rebars can greatly improve the resistance of the beam;The seismic resistance,internal explosion resistance,and progressive collapse resistance of reinforced concrete frame structures with kinked rebar have significantly improved.Beyond its primary application,the principle of kinked rebar was extended to other applications of kinked materials such as corrugated steel plates and origami structures,and the stress characteristics of related components and structures were studied.Intriguingly,this paper also proposes the application of kinked rebars in bridge engineering,aiming to address the challenges of localized damage concentration and excessive residual displacement in RC bridge piers.The introduction of kinked rebars in piers is envisioned to mitigate these issues,with the paper outlining its advantages and feasibility,thereby offering valuable insights for future research on kinked reinforcement and seismic design strategies for bridges. 展开更多
关键词 Structural engineering kinked rebar seismic performance explosion-resistant performance progressive collapse
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