Inflammatory bowel disease(IBD)is a chronic condition consisting of two main types:Crohn’s disease and ulcerative colitis.Conventional treatments for these diseases include aminosalicylates,corticosteroids,immunomodu...Inflammatory bowel disease(IBD)is a chronic condition consisting of two main types:Crohn’s disease and ulcerative colitis.Conventional treatments for these diseases include aminosalicylates,corticosteroids,immunomodulators,and biologics.However,these treatments have several drawbacks,including high costs for patients and numerous side effects.Recently,advanced treatments have been developed,such as small-molecule therapies,targeted biologics,innovative drug delivery systems,and microbiome-based interventions.Emerging therapies like anti-interleukin-23 monoclonal antibody inhibitors,sphingosine-1-phosphate receptor modulators,and Janus kinase inhibitors are more specialized in reducing immune activity.They enhance bioavailability,reduce side effects,and specifically target the gastrointestinal tract without affecting other systems.Innovative drug delivery systems for IBD,such as nanoparticles,hydrogels,and microgrippers,improve bioavailability and prolong drug release.The combination of conventional and advanced therapies may benefit from the synergistic effects of both.Furthermore,fecal microbiota transplantation and probiotics can help restore the balance of gastrointestinal microbiota,reducing disease flare-ups.Advances in artificial intelligence,endoscopic techniques,and stem cell therapies have shown great potential in treating IBD,although several significant challenges remain.Treating this disease requires multidisciplinary integration and the application of technology and telemedicine.展开更多
BACKGROUND Barrett esophagus(BE),a metaplastic adaptive process to gastrointestinal reflux,is associated with a higher risk of developing esophageal adenocarcinoma.However,the factors and mechanism that drive the mali...BACKGROUND Barrett esophagus(BE),a metaplastic adaptive process to gastrointestinal reflux,is associated with a higher risk of developing esophageal adenocarcinoma.However,the factors and mechanism that drive the malignant progression of BE is not well understood.AIM To investigate the role of bile acids,a component of the reflux fluid,in the malignant progression of BE.METHODS Using engineered green fluorescent protein-labeled adult tissue-resident stem cells isolated from BE clinical biopsies(BE-ASCs)as the target,we studied the effect of hydrophobic deoxycholic acid(DCA)and hydrophilic tetrahydroxylated bile acids(THBA)on cell viability by fluorescence intensity analysis,mucin production by dark density measurement,tissue structure by pathology analysis,expression of different pro-inflammatory factors gene by quantitative polymerase chain reaction and proteins by Western blot.RESULTS We found that hydrophobic DCA has cytotoxic and proinflammatory effects through activation of interleukin-1β(IL-1β)-nuclear factor kappa-B(NF-κB)inflammatory pathway on BE-ASCs.This action results in impaired cell viability,tissue intactness,reduced mucin production,and increased transition to disorganized atypical cells without intestinal features.In contrast,co-culture with hydrophilic THBA inhibited the IL-1β-NF-κB inflammatory pathway with maintenance of mature intestinal type cellular and histomorphology.CONCLUSION Our data indicates that the hydrophilic bile acid THBA can counteract the cytotoxic and proinflammatory effect of hydrophobic DCA and prevent the malignant progression of BE by inhibiting the IL-1β-NF-κB pathway.展开更多
Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environment...Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol(1,6-HDO) with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments(LCAs).Strategy A was found to be the most favorable both economically(USRDSCHARDOLLAR3,402/ton) and environmentally(-26.9 kg CO_(2)eq.). This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.展开更多
As environmental concerns from fossil fuel consumption intensify,large-scale energy storage becomes imperative for the integration of renewable sources like wind,hydro,and solar with the electrical grid.Redox flow bat...As environmental concerns from fossil fuel consumption intensify,large-scale energy storage becomes imperative for the integration of renewable sources like wind,hydro,and solar with the electrical grid.Redox flow batteries,particularly those employing organic molecules,are positioned as a key technology for this purpose.This review explores the growing field of symmetric organic redox flow batteries(ORFBs)within this context.Unlike traditional asymmetric designs based on unique active materials for each electrode,symmetric ORFBs involve a single bipolar species for both electrodes.This review highlights the benefits of a symmetric design,and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents.By providing a comprehensive overview of their cell cycling and performance characteristics,the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems,as are opportunities for future development.This should guide new research directions and advance the development of practical symmetric ORFBs.展开更多
This study investigates the complex heat transfer dynamics inmultilayer bifacial photovoltaic(bPV)solar modules under spectrally resolved solar irradiation.A novel numericalmodel is developed to incorporate internal h...This study investigates the complex heat transfer dynamics inmultilayer bifacial photovoltaic(bPV)solar modules under spectrally resolved solar irradiation.A novel numericalmodel is developed to incorporate internal heat generation resulting from optical absorption,grounded in the physical equations governing light-matter interactions within the module’smultilayer structure.The model accounts for reflection and transmission at each interface between adjacent layers,as well as absorption within individual layers,using the wavelength-dependent dielectric properties of constituent materials.These properties are used to calculate the spectral reflectance,transmittance,and absorption coefficients,enabling precise quantification of internal heat sources from irradiance incidents on both the front and rear surfaces of the module.The study further examines the influence of irradiance reflection on thermal behavior,evaluates the thermal impact of various supporting materials placed beneath the module,and analyzes the role of albedo in modifying heat distribution.By incorporating spectrally resolved heat generation across each layer often simplified or omitted in conventional models,the proposed approach enhances physical accuracy.The transient heat equation is solved using a one-dimensional finite difference(FD)method to produce detailed temperature profiles under multiple operating scenarios,including Standard Test Conditions(STC),Bifacial Standard Test Conditions(BSTC),Normal Operating Cell Temperature(NOCT),and Bifacial NOCT(BNOCT).The results offer valuable insights into the interplay between optical and thermal phenomena in bifacial systems,informing the design and optimization of more efficient photovoltaic technologies.展开更多
The advent of precision medicine has underscored the importance of biomarkers in predicting therapy response for bladder cancer,a malignancy marked by considerable heterogeneity.This review critically examines the cur...The advent of precision medicine has underscored the importance of biomarkers in predicting therapy response for bladder cancer,a malignancy marked by considerable heterogeneity.This review critically examines the current landscape of biomarkers to forecast treatment outcomes in bladder cancer patients.We explore a range of biomarkers,including genetic,epigenetic,proteomic,and transcriptomic indicators,from multiple sample sources,including urine,tumor tissue and blood,assessing their efficacy in predicting responses to chemotherapy,immunotherapy,and targeted therapies.Despite promising developments,the translation of these biomarkers into clinical practice faces significant challenges,such as variability in biomarker performance,the necessity for large-scale validation studies,and the integration of biomarker testing into routine clinical workflows.We also highlight the need for standardized methodologies and robust assays to ensure consistency and reliability.Future directions point towards longitudinal studies and the development of combination biomarker panels to enhance predictive accuracy.This review emphasizes the transformative potential of predictive biomarkers in improving patient outcomes and advocates for continued collaborative efforts to overcome existing barriers in this rapidly evolving field.展开更多
We explored a distinct mechanism for matter creation via electron-positron pair production during bound-bound transitions in the deexcitation of muonic atoms.For ions with nuclear charges Z≥24,transitions from low-ly...We explored a distinct mechanism for matter creation via electron-positron pair production during bound-bound transitions in the deexcitation of muonic atoms.For ions with nuclear charges Z≥24,transitions from low-lying excited states to the 1s-muon state can lead to the production of electron-positron pairs.We show that the Breit interaction determines the transition probabilities for states with nonzero orbital momentum.We show that the pair production arises mainly from the decay of the 2p states.Thus,the Breit interaction governs electron-positron pair production in bound-bound muon transitions.This process offers a unique opportunity to explore quantum electrodynamics in strong fields,as well as a class of nonradiative transitions involving electron-positron pair production.展开更多
Fibroblast activation protein(FAP)is overexpressed in cancer-associated fibroblasts across various cancer types.Numerous radiolabeled FAP inhibitors(FAPIs)(Fig.S1A)currently under clinical investigation have shown rem...Fibroblast activation protein(FAP)is overexpressed in cancer-associated fibroblasts across various cancer types.Numerous radiolabeled FAP inhibitors(FAPIs)(Fig.S1A)currently under clinical investigation have shown remarkable potential in cancer theranostics.展开更多
Slow-moving landslides are widespread in the Mediterranean area,causing damage to the exposed facilities and economic losses in many countries.The recognition of slow-moving landslides in urban areas is always a diffi...Slow-moving landslides are widespread in the Mediterranean area,causing damage to the exposed facilities and economic losses in many countries.The recognition of slow-moving landslides in urban areas is always a difficult task to deal with because the presence of buildings,infrastructures,and human activities usually conceals the morphological signs of these landslide activities.So,in the last decades,numerous researchers have shown new methodologies to deepen the studies of similar instability phenomena.The present research is based on an integrated approach to investigate the landslide boundaries,type of movement,failure surface depth,and vulnerability state of buildings in Rota Greca Village(Calabria region,southern Italy) affected by a slowmoving landslide.For this purpose,multi-source data were acquired through geological and geomorphological surveys,recognition of landslide-induced damage on the built environment,subsurface investigations(e.g.,continuous drill boreholes,Standard Penetration Test,Rock Quality Designation index and inclinometer monitoring),laboratory tests(direct shear tests on undisturbed samples),geophysical survey,and InSAR-derived map of deformation rates.The complete integration of multi-source data allowed for the construction of reliable landslide modelling with relative geotechnical properties.In addition,the cross-comparison between surface deformation data by SAR images and severity damage level collected on the exposed buildings enabled to obtain the vulnerability map of the built area.In particular,the achieved goals highlighted two failure surfaces at about-13 and-25 m depth,causing a high vulnerability value for the buildings allocated in the central portion of the Rota Greca Village.The knowledge acquired by the multi-approach can be used to manage and implement appropriate landslide risk mitigation strategies,providing helpful advice and best practices to state-run organisations and stakeholders for landslide management in urban sites.展开更多
Background Necrotic enteritis(NE)is an economically important disease of broiler chickens caused by Clostridium perfringens(CP).The pathogenesis,or disease process,of NE is still not clear.This study aimed to identify...Background Necrotic enteritis(NE)is an economically important disease of broiler chickens caused by Clostridium perfringens(CP).The pathogenesis,or disease process,of NE is still not clear.This study aimed to identify the alterations of metabolites and metabolic pathways associated with subclinical or clinical NE in CP infected birds and to investi-gate the possible variations in the metabolic profile of birds infected with different isolates of CP.Methodology Using a well-established NE model,the protein content of feed was changed abruptly before expos-ing birds to CP isolates with different toxin genes combinations(cpa,cpb2,netB,tpeL;cpa,cpb2,netB;or cpa,cpb2).Metabolomics analysis of jejunal contents was performed by a targeted,fully quantitative LC-MS/MS based assay.Results This study detected statistically significant differential expression of 34 metabolites including organic acids,amino acids,fatty acids,and biogenic amines,including elevation of butyric acid at onset of NE in broiler chickens.Subsequent analysis of broilers infected with CP isolates with different toxin gene combinations confirmed an eleva-tion of butyric acid consistently among 21 differentially expressed metabolites including organic acids,amino acids,and biogenic amines,underscoring its potential role during the development of NE.Furthermore,protein-metabolite network analysis revealed significant alterations in butyric acid and arginine-proline metabolisms.Conclusion This study indicates a significant metabolic difference between CP-infected and non-infected broiler chickens.Among all the metabolites,butyric acid increased significantly in CP-infected birds compared to non-infected healthy broilers.Logistic regression analysis revealed a positive association between butyric acid(coefficient:1.23,P<0.01)and CP infection,while showing a negative association with amino acid metabolism.These findings suggest that butyric acid could be a crucial metabolite linked to the occurrence of NE in broiler chickens and may serve as an early indicator of the disease at the farm level.Further metabolomic experiments using different NE animal models and field studies are needed to determine the specificity and to validate metabolites associated with NE,regardless of predisposing factors.展开更多
BACKGROUND Environmental enteric dysfunction(EED)is a subclinical condition caused by fecal-oral contamination leading to enteric inflammation and dysbiosis.Bile acids serve to facilitate lipid digestion and absorptio...BACKGROUND Environmental enteric dysfunction(EED)is a subclinical condition caused by fecal-oral contamination leading to enteric inflammation and dysbiosis.Bile acids serve to facilitate lipid digestion and absorption,regulate metabolic pathways associated with childhood growth and inflammation,and may be affected by EED.AIM To investigate bile acid metabolism in Bangladeshi children with EED and its association with growth impairment.METHODS We conducted a cross-sectional study of 100 Bangladeshi infants(aged 6-9 months)and quantified serum and fecal bile acids using LC-MS/MS.We compared profiles to a control group of 6 American children(6-12 months)and 80 older Bangladeshi children(aged 2 years).RESULTS Bangladeshi infants had higher levels of plasma unconjugated primary(65.23%vs 44.25%,P=0.003)and sulfated primary bile acids(12.98%vs<0.001%,P=0.01),with lower primary conjugated bile acids(0.69%vs 2.74%,P≤0.001)compared to American children.Stool unconjugated primary bile acids were inversely associated with weight-for-age[regression coefficient(β)=-0.01,P=0.01]and height-for-age Z scores(β=-0.01,P=0.03).Conjugated secondary bile acids were inversely associated with small intestine bacterial overgrowth(β=-1096.68,P=0.05).Fecal myeloperoxidase was associated with sulfated secondary bile acids(β=-0.40,P=0.04).Compared to 2-year-old children,the Bangladeshi infant’s serum had higher levels of unconjugated primary bile acids(65.23%vs 9.20%,P≤0.001)and lower levels of primary conjugated bile acids(0.69%vs 80.38%,P≤0.001).CONCLUSION Our data suggests an age-dependent defect in conjugation of primary bile acids in Bangladeshi children with compensatory hydrophilic shunting.Additionally,bile acid profiles are associated with intestinal overgrowth.展开更多
BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare mesenchymal tumors that rarely present with gastrointestinal(GI)bleeding due to tumor erosion.GISTs com-Core Tip:Gastrointestinal stromal tumors(GISTs)are rare...BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare mesenchymal tumors that rarely present with gastrointestinal(GI)bleeding due to tumor erosion.GISTs com-Core Tip:Gastrointestinal stromal tumors(GISTs)are rare mesenchymal tumors that rarely cause gastrointestinal(GI)bleeding.Mucosal ulceration and unfavorable tumor locations are risk factors for tumor progression and malignancy.We present a case of GI bleeding in a 42-year-old man complaining of melena over five days,which was diagnosed as a benign,ulcerated,jejunal GIST on histopathology and immunohistochemistry.Prompt evaluation using specialized diagnostic tools to locate obscure bleeding sources and complete surgical resection are key to favorable outcomes.GI bleeding in GIST is associated with a poor prognosis.Hence,detailed follow-ups are essential to detect and prevent tumor recurrence.INTRODUCTION Gastrointestinal stromal tumors(GISTs)are generally recognized as spindle cell,epithelioid,or occasionally pleomorphic tumors that usually develop in the gastrointestinal(GI)tract.Originating from mesenchymal cells of the GI tract,GISTs make up 1%-3%of all GI malignancies and progress to malignancy in approximately 10%to 30%of cases[1,2].A greater risk of tumor progression is linked to GISTs associated with mucosal ulceration and those that develop outside of the stomach[1,3].Many GISTs carry mutations in the genes encoding type III receptor tyrosine kinases,particularly KIT or PDGFRA,which is the case in up to 85%of instances.A significant majority,about 95%,of these tumors are positive for the KIT protein when tested with immunohistochemistry[4].The most common places where GIST arises are the stomach,followed by the small bowel[2].In 19%of cases,GISTs manifest asymptomatically,particularly in cases of smaller tumors of the intestinal tract.Studies show that around 10%of these cases were caught at autopsy and 20%during abdominal surgery for other conditions,making them a common incidental finding rather than a clinical suspicion[5,6].Patients who are symptomatic may exhibit non-specific symptoms such as nausea,vomiting,abdominal distension,early satiety,abdominal pain,and,in rare cases,a palpable abdominal mass.Obstruction of the GI lumen by endophytic growth or compression of the GI tract by exophytic growth may result in dysphagia,obstructive jaundice,or constipation in larger tumors,contingent upon the mass's specific location[1].Very rarely do these tumors present as an acute,severe,life-threatening GI bleeding[7].Herein,we describe a case report of a rather unusual presentation of GIST,i.e.,symptomatic GI bleeding caused by an ulcerated jejunal GIST,which was found to be benign in nature.This case report emphasizes the importance of maintaining a high suspicion of this disease when all routine workups for GI bleeding show no obvious findings.展开更多
Metabolic dysfunction-associated steatotic liver disease is increasingly understood to be closely linked with skeletal muscle alterations,such as sarcopenia,myoste-atosis,and metabolic dysregulation,which play a key r...Metabolic dysfunction-associated steatotic liver disease is increasingly understood to be closely linked with skeletal muscle alterations,such as sarcopenia,myoste-atosis,and metabolic dysregulation,which play a key role in its pathogenesis and progression.Recent literature,including an article by Isakov,highlights the bidirectional interactions between muscle and liver,underscoring shared mechanisms such as insulin resistance,inflammation,and myokine imbalance.This letter reflects on key findings from the review,noting strengths such as its integration of mechanistic insights,discussion of emerging biomarkers,and emphasis on lifestyle and pharmacological interventions.It also identifies areas for further development,including standardization of diagnostic criteria and more rigorous evaluation of translational data.As muscle health gains promi-nence in metabolic dysfunction-associated steatotic liver disease research,multidisciplinary strategies that target both hepatic and muscular systems may offer more effective avenues for prevention and treatment.展开更多
The buckling behavior of stiffened panels is significantly influenced by material and geometric defects,making it a critical factor in ensuring structural integrity and safety.These panels are widely used in mechanica...The buckling behavior of stiffened panels is significantly influenced by material and geometric defects,making it a critical factor in ensuring structural integrity and safety.These panels are widely used in mechanical,aerospace,marine,and civil engineering applications due to their ability to enhance bending stiffness with minimal additional weight.Under high loads or stress concentrations,localized structural failures can initiate global buckling in stiffened panels.This study investigates how such defects affect the critical buckling load,stiffness,and thickness of stiffened panels.Two finite element analyses were conducted:a linear analysis to identify the initial buckling mode and a nonlinear analysis using the Riks algorithm in Abaqus CAE,incorporating localized imperfections.The simulations show that material and geometric defects can reduce buckling resistance depending on their severity.展开更多
Background:Community-acquired bacterial pneumonia(CABP)poses a serious public health threat,particularly with the emergence of drug-resistant bacterial strains.This study aims to investigate the molecular interactions...Background:Community-acquired bacterial pneumonia(CABP)poses a serious public health threat,particularly with the emergence of drug-resistant bacterial strains.This study aims to investigate the molecular interactions of Nafithromycin(Miqnaf®),India’s first indigenous next-generation macrolide antibiotic,and evaluate its potential against Streptococcus pneumoniae,a key pathogen responsible for CABP.Targeting 23S rRNA is critical for overcoming antibiotic resistance since it is involved in bacterial protein production.Many antibiotics,including macrolides target this rRNA.Mutations in 23S rRNA frequently result in resistance;therefore,designing medicines that bind new or conserved areas of 23S rRNA can circumvent current resistance mechanisms and restore antibiotic potency.Nafithromycin has excellent therapeutic potential,with a short three-day regimen and much higher efficacy than conventional macrolides.Its high lung tissue penetration and robust effectiveness against drug-resistant respiratory bacteria make it a promising next-generation antibiotic.Methods:To elucidate the interaction of Nafithromycin with bacterial ribosomal RNA,molecular docking studies were performed using AutoDock Vina.The three-dimensional structure of Streptococcus pneumoniae 23S rRNA was retrieved from the Protein Data Bank(PDB).The ligand structure of Nafithromycin was obtained from the PubChem database and prepared using Open Babel.Docking simulations targeted key functional regions-Domains II and V of 23S rRNA-known to be critical for bacterial protein synthesis.Binding affinities were calculated,and molecular interactions such as hydrogen bonds,hydrophobic contacts,and conformational stabilities were analyzed using Discovery Studio and PyMOL.Results:Nafithromycin exhibited a high binding affinity of-10.3 kcal/mol toward S.pneumoniae 23S rRNA.The compound formed stable interactions with both Domain II and Domain V,crucial regions involved in the inhibition of bacterial protein synthesis.Hydrogen bonding and hydrophobic interactions further stabilized the ligand-receptor complex.Compared to azithromycin,Nafithromycin demonstrated superior binding efficacy and a greater potential to inhibit resistant bacterial strains,indicating its structural advantages and enhanced ribosomal targeting.Conclusion:Nafithromycin demonstrates significant potential as a potent therapeutic agent against drug-resistant CABP.Its strong binding affinity,stable interactions with bacterial rRNA,favorable pharmacokinetic profile,and reduced resistance risk support its clinical utility and suggest its advantage over traditional macrolide antibiotics such as azithromycin.展开更多
Forests play a vital role in mitigating climate change through their physiological functions and metabolic processes,including their ability to convert solar energy into biomolecules.However,further research is necess...Forests play a vital role in mitigating climate change through their physiological functions and metabolic processes,including their ability to convert solar energy into biomolecules.However,further research is necessary to elucidate how structural characteristics of a forest and topographic settings influence energy conversion and surface temperature of a forest.In this study,we investigated a beech forest in central Germany using airborne laser scanning(ALS)point cloud data and land surface temperature(LST)data derived from Landsat 9 satellite imagery.We constructed 30 m×30 m plots across the study area(approximately 17 km2)to align the spatial resolution of the satellite imagery with the ALS data.We analyzed topographic variables(surface elevation,aspect and slope),forest attributes(canopy cover,canopy height,and woody area index),as well as forest structural complexity,quantified by the box-dimension(Db).Our analysis revealed that LST is significantly influenced by both forest attributes and topographic variables.A multiple linear regression model demonstrated an inverse relationship(R^(2)=0.38,AIC=8105)between LST and a combination of Db,elevation,slope,and aspect.However,the model residuals exhibited significant spatial dependency,as indicated by Moran’s I test.To address this,we applied a spatial autoregressive model,which effectively accounted for spatial autocorrelation and improved the model fit(AIC=746).Our findings indicate that elevation exerts the most substantial influence on LST,followed by forest structural complexity,slope,and aspect.We conclude that forest management practices that enhance structural complexity can effectively reduce land surface temperatures in forested landscapes.展开更多
The Arctic region is experiencing accelerated sea ice melt and increased iceberg detachment from glaciers due to climate change.These drifting icebergs present a risk and engineering challenge for subsea installations...The Arctic region is experiencing accelerated sea ice melt and increased iceberg detachment from glaciers due to climate change.These drifting icebergs present a risk and engineering challenge for subsea installations traversing shallow waters,where ice-berg keels may reach the seabed,potentially damaging subsea structures.Consequently,costly and time-intensive iceberg manage-ment operations,such as towing and rerouting,are undertaken to safeguard subsea and offshore infrastructure.This study,therefore,explores the application of extra tree regression(ETR)as a robust solution for estimating iceberg draft,particularly in the preliminary phases of decision-making for iceberg management projects.Nine ETR models were developed using parameters influencing iceberg draft.Subsequent analyses identified the most effective models and significant input variables.Uncertainty analysis revealed that the superior ETR model tended to overestimate iceberg drafts;however,it achieved the highest precision,correlation,and simplicity in estimation.Comparison with decision tree regression,random forest regression,and empirical methods confirmed the superior perfor-mance of ETR in predicting iceberg drafts.展开更多
Aramid papers (AP), made of aramid fibers, demonstrate superiority in electrical insulation applications. Unfortunately, the strength and electrical insulating properties of AP remain suboptimal, primarily due to the ...Aramid papers (AP), made of aramid fibers, demonstrate superiority in electrical insulation applications. Unfortunately, the strength and electrical insulating properties of AP remain suboptimal, primarily due to the smooth surface and chemical inertness of aramid fibers. Herein, AP are modified via the nacre-mimetic structure composed of aramid nanofibers (ANF) and carbonylated basalt nanosheets (CBSNs). This is achieved by impregnating AP into an ANF-CBSNs (A-C) suspension containing a 3D ANF framework as the matrix and 2D CBSNs as fillers. The resultant biomimetic composite papers (AP/A-C composite papers) exhibit a layered “brick-and-mortar” structure, demonstrating superior mechanical and electrical insulating properties. Notably, the tensile strength and breakdown strength of AP/A-C5 composite papers reach 39.69 MPa and 22.04 kV mm^(−1), respectively, representing a 155 % and 85 % increase compared to those of the control AP. These impressive properties are accompanied with excellent volume resistivity, exceptional dielectric properties, impressive folding endurance, outstanding heat insulation, and remarkable flame retardance. The nacre-inspired strategy offers an effective approach for producing highly promising electrical insulating papers for advanced electrical equipment.展开更多
TriboElectric NanoGenerators(TENGs),introduced in 2012 by Wang et al.,have revolutionized the way we harvest energy,converting mechanical energy into electrical power with remarkable efficiency.Since their inception,T...TriboElectric NanoGenerators(TENGs),introduced in 2012 by Wang et al.,have revolutionized the way we harvest energy,converting mechanical energy into electrical power with remarkable efficiency.Since their inception,TENGs have unlocked innumerable applications,driving a surge in innovative research and development.This study utilizes the Scopus database to conduct a bibliographic analysis,highlighting the diverse applications,influential authors,and citation patterns that define the TENG landscape.Through the use of MATLAB and VOSviewer,we provide a visually compelling analysis that not only shows the integration of artificial intelligence in scientific literature but also explores the challenges and future potential of TENG technology.The document concludes by discussing TENGs challenges and the promising paths for their future applications.展开更多
文摘Inflammatory bowel disease(IBD)is a chronic condition consisting of two main types:Crohn’s disease and ulcerative colitis.Conventional treatments for these diseases include aminosalicylates,corticosteroids,immunomodulators,and biologics.However,these treatments have several drawbacks,including high costs for patients and numerous side effects.Recently,advanced treatments have been developed,such as small-molecule therapies,targeted biologics,innovative drug delivery systems,and microbiome-based interventions.Emerging therapies like anti-interleukin-23 monoclonal antibody inhibitors,sphingosine-1-phosphate receptor modulators,and Janus kinase inhibitors are more specialized in reducing immune activity.They enhance bioavailability,reduce side effects,and specifically target the gastrointestinal tract without affecting other systems.Innovative drug delivery systems for IBD,such as nanoparticles,hydrogels,and microgrippers,improve bioavailability and prolong drug release.The combination of conventional and advanced therapies may benefit from the synergistic effects of both.Furthermore,fecal microbiota transplantation and probiotics can help restore the balance of gastrointestinal microbiota,reducing disease flare-ups.Advances in artificial intelligence,endoscopic techniques,and stem cell therapies have shown great potential in treating IBD,although several significant challenges remain.Treating this disease requires multidisciplinary integration and the application of technology and telemedicine.
文摘BACKGROUND Barrett esophagus(BE),a metaplastic adaptive process to gastrointestinal reflux,is associated with a higher risk of developing esophageal adenocarcinoma.However,the factors and mechanism that drive the malignant progression of BE is not well understood.AIM To investigate the role of bile acids,a component of the reflux fluid,in the malignant progression of BE.METHODS Using engineered green fluorescent protein-labeled adult tissue-resident stem cells isolated from BE clinical biopsies(BE-ASCs)as the target,we studied the effect of hydrophobic deoxycholic acid(DCA)and hydrophilic tetrahydroxylated bile acids(THBA)on cell viability by fluorescence intensity analysis,mucin production by dark density measurement,tissue structure by pathology analysis,expression of different pro-inflammatory factors gene by quantitative polymerase chain reaction and proteins by Western blot.RESULTS We found that hydrophobic DCA has cytotoxic and proinflammatory effects through activation of interleukin-1β(IL-1β)-nuclear factor kappa-B(NF-κB)inflammatory pathway on BE-ASCs.This action results in impaired cell viability,tissue intactness,reduced mucin production,and increased transition to disorganized atypical cells without intestinal features.In contrast,co-culture with hydrophilic THBA inhibited the IL-1β-NF-κB inflammatory pathway with maintenance of mature intestinal type cellular and histomorphology.CONCLUSION Our data indicates that the hydrophilic bile acid THBA can counteract the cytotoxic and proinflammatory effect of hydrophobic DCA and prevent the malignant progression of BE by inhibiting the IL-1β-NF-κB pathway.
基金Material Parts Technology Development Program (20017461, Development and Performance Improvement of Air Operated Valve for 105 MPa Hydrogen Charging Station) funded by the Ministry of Trade,Industry and Energy(MOTIE, Republic of Korea)Korea Evaluation Institute of Industrial Technology (KEIT, Republic of Korea)+1 种基金financial support from the Korea Institute of Energy Technology Evaluation and Planning (KETEP)Ministry of Trade,Industry&Energy (MOTIE) of the Republic of Korea(RS-2024-00419764)。
文摘Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol(1,6-HDO) with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments(LCAs).Strategy A was found to be the most favorable both economically(USRDSCHARDOLLAR3,402/ton) and environmentally(-26.9 kg CO_(2)eq.). This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.
基金Natural Sciences and Engineering Research Council(NSERC)of Canada(RGPIN-2022-03488)New Brunswick Innovation Foundation(NBIF)。
文摘As environmental concerns from fossil fuel consumption intensify,large-scale energy storage becomes imperative for the integration of renewable sources like wind,hydro,and solar with the electrical grid.Redox flow batteries,particularly those employing organic molecules,are positioned as a key technology for this purpose.This review explores the growing field of symmetric organic redox flow batteries(ORFBs)within this context.Unlike traditional asymmetric designs based on unique active materials for each electrode,symmetric ORFBs involve a single bipolar species for both electrodes.This review highlights the benefits of a symmetric design,and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents.By providing a comprehensive overview of their cell cycling and performance characteristics,the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems,as are opportunities for future development.This should guide new research directions and advance the development of practical symmetric ORFBs.
文摘This study investigates the complex heat transfer dynamics inmultilayer bifacial photovoltaic(bPV)solar modules under spectrally resolved solar irradiation.A novel numericalmodel is developed to incorporate internal heat generation resulting from optical absorption,grounded in the physical equations governing light-matter interactions within the module’smultilayer structure.The model accounts for reflection and transmission at each interface between adjacent layers,as well as absorption within individual layers,using the wavelength-dependent dielectric properties of constituent materials.These properties are used to calculate the spectral reflectance,transmittance,and absorption coefficients,enabling precise quantification of internal heat sources from irradiance incidents on both the front and rear surfaces of the module.The study further examines the influence of irradiance reflection on thermal behavior,evaluates the thermal impact of various supporting materials placed beneath the module,and analyzes the role of albedo in modifying heat distribution.By incorporating spectrally resolved heat generation across each layer often simplified or omitted in conventional models,the proposed approach enhances physical accuracy.The transient heat equation is solved using a one-dimensional finite difference(FD)method to produce detailed temperature profiles under multiple operating scenarios,including Standard Test Conditions(STC),Bifacial Standard Test Conditions(BSTC),Normal Operating Cell Temperature(NOCT),and Bifacial NOCT(BNOCT).The results offer valuable insights into the interplay between optical and thermal phenomena in bifacial systems,informing the design and optimization of more efficient photovoltaic technologies.
文摘The advent of precision medicine has underscored the importance of biomarkers in predicting therapy response for bladder cancer,a malignancy marked by considerable heterogeneity.This review critically examines the current landscape of biomarkers to forecast treatment outcomes in bladder cancer patients.We explore a range of biomarkers,including genetic,epigenetic,proteomic,and transcriptomic indicators,from multiple sample sources,including urine,tumor tissue and blood,assessing their efficacy in predicting responses to chemotherapy,immunotherapy,and targeted therapies.Despite promising developments,the translation of these biomarkers into clinical practice faces significant challenges,such as variability in biomarker performance,the necessity for large-scale validation studies,and the integration of biomarker testing into routine clinical workflows.We also highlight the need for standardized methodologies and robust assays to ensure consistency and reliability.Future directions point towards longitudinal studies and the development of combination biomarker panels to enhance predictive accuracy.This review emphasizes the transformative potential of predictive biomarkers in improving patient outcomes and advocates for continued collaborative efforts to overcome existing barriers in this rapidly evolving field.
基金supported by the National Key Research and Development Program of China(Grant No.2022YFA1602501)the National Natural Science Foundation of China(Grant No.12011530060)+1 种基金supported solely by the Russian Science Foundation(Grant No.22-12-00043)supported by the Chinese Academy of Sciences(CAS)Presidents International Fellowship Initiative(PIFI)(Grant Nos.2018VMB0016 and 2022VMC0002),respectively。
文摘We explored a distinct mechanism for matter creation via electron-positron pair production during bound-bound transitions in the deexcitation of muonic atoms.For ions with nuclear charges Z≥24,transitions from low-lying excited states to the 1s-muon state can lead to the production of electron-positron pairs.We show that the Breit interaction determines the transition probabilities for states with nonzero orbital momentum.We show that the pair production arises mainly from the decay of the 2p states.Thus,the Breit interaction governs electron-positron pair production in bound-bound muon transitions.This process offers a unique opportunity to explore quantum electrodynamics in strong fields,as well as a class of nonradiative transitions involving electron-positron pair production.
基金supported by the grants provided by Zhuhai People's Hospital,China(Grant No.:2021KYQD-03)the National Natural Science Foundation of China(Grant No.:22176016).
文摘Fibroblast activation protein(FAP)is overexpressed in cancer-associated fibroblasts across various cancer types.Numerous radiolabeled FAP inhibitors(FAPIs)(Fig.S1A)currently under clinical investigation have shown remarkable potential in cancer theranostics.
基金supported by the MIUR-ex 60% Project(responsibility of Fabio Ietto)。
文摘Slow-moving landslides are widespread in the Mediterranean area,causing damage to the exposed facilities and economic losses in many countries.The recognition of slow-moving landslides in urban areas is always a difficult task to deal with because the presence of buildings,infrastructures,and human activities usually conceals the morphological signs of these landslide activities.So,in the last decades,numerous researchers have shown new methodologies to deepen the studies of similar instability phenomena.The present research is based on an integrated approach to investigate the landslide boundaries,type of movement,failure surface depth,and vulnerability state of buildings in Rota Greca Village(Calabria region,southern Italy) affected by a slowmoving landslide.For this purpose,multi-source data were acquired through geological and geomorphological surveys,recognition of landslide-induced damage on the built environment,subsurface investigations(e.g.,continuous drill boreholes,Standard Penetration Test,Rock Quality Designation index and inclinometer monitoring),laboratory tests(direct shear tests on undisturbed samples),geophysical survey,and InSAR-derived map of deformation rates.The complete integration of multi-source data allowed for the construction of reliable landslide modelling with relative geotechnical properties.In addition,the cross-comparison between surface deformation data by SAR images and severity damage level collected on the exposed buildings enabled to obtain the vulnerability map of the built area.In particular,the achieved goals highlighted two failure surfaces at about-13 and-25 m depth,causing a high vulnerability value for the buildings allocated in the central portion of the Rota Greca Village.The knowledge acquired by the multi-approach can be used to manage and implement appropriate landslide risk mitigation strategies,providing helpful advice and best practices to state-run organisations and stakeholders for landslide management in urban sites.
基金support for the project was provided by Chicken Farmers of Saskatchewan(424357)Canadian Poultry Research Council(424854)+1 种基金Natural Sciences and Engineering Research Council of Canada(424679)Saskatchewan Agriculture Development Fund(426954).
文摘Background Necrotic enteritis(NE)is an economically important disease of broiler chickens caused by Clostridium perfringens(CP).The pathogenesis,or disease process,of NE is still not clear.This study aimed to identify the alterations of metabolites and metabolic pathways associated with subclinical or clinical NE in CP infected birds and to investi-gate the possible variations in the metabolic profile of birds infected with different isolates of CP.Methodology Using a well-established NE model,the protein content of feed was changed abruptly before expos-ing birds to CP isolates with different toxin genes combinations(cpa,cpb2,netB,tpeL;cpa,cpb2,netB;or cpa,cpb2).Metabolomics analysis of jejunal contents was performed by a targeted,fully quantitative LC-MS/MS based assay.Results This study detected statistically significant differential expression of 34 metabolites including organic acids,amino acids,fatty acids,and biogenic amines,including elevation of butyric acid at onset of NE in broiler chickens.Subsequent analysis of broilers infected with CP isolates with different toxin gene combinations confirmed an eleva-tion of butyric acid consistently among 21 differentially expressed metabolites including organic acids,amino acids,and biogenic amines,underscoring its potential role during the development of NE.Furthermore,protein-metabolite network analysis revealed significant alterations in butyric acid and arginine-proline metabolisms.Conclusion This study indicates a significant metabolic difference between CP-infected and non-infected broiler chickens.Among all the metabolites,butyric acid increased significantly in CP-infected birds compared to non-infected healthy broilers.Logistic regression analysis revealed a positive association between butyric acid(coefficient:1.23,P<0.01)and CP infection,while showing a negative association with amino acid metabolism.These findings suggest that butyric acid could be a crucial metabolite linked to the occurrence of NE in broiler chickens and may serve as an early indicator of the disease at the farm level.Further metabolomic experiments using different NE animal models and field studies are needed to determine the specificity and to validate metabolites associated with NE,regardless of predisposing factors.
基金Supported by Children’s Hospital Foundation at VCU,No.1K23HD097282(to Donowitz JR)National Institutes of Health,No.5R01AI043596(to Donowitz JR)+6 种基金Bill and Melinda Gates Foundation,No.OPP1017093VA Merit Award,No.1I01BX005730VA ShEEP Grants,No.1 IS1 BX004777-01National Institutes of Health Grant,No.2R56DK115377-05A1PIDS Summer Research Scholars AwardVCU SOM Dean’s Summer Research Fellowshipand Research Career Scientist Award from the Department of Veterans Affairs,No.IK6BX004477.
文摘BACKGROUND Environmental enteric dysfunction(EED)is a subclinical condition caused by fecal-oral contamination leading to enteric inflammation and dysbiosis.Bile acids serve to facilitate lipid digestion and absorption,regulate metabolic pathways associated with childhood growth and inflammation,and may be affected by EED.AIM To investigate bile acid metabolism in Bangladeshi children with EED and its association with growth impairment.METHODS We conducted a cross-sectional study of 100 Bangladeshi infants(aged 6-9 months)and quantified serum and fecal bile acids using LC-MS/MS.We compared profiles to a control group of 6 American children(6-12 months)and 80 older Bangladeshi children(aged 2 years).RESULTS Bangladeshi infants had higher levels of plasma unconjugated primary(65.23%vs 44.25%,P=0.003)and sulfated primary bile acids(12.98%vs<0.001%,P=0.01),with lower primary conjugated bile acids(0.69%vs 2.74%,P≤0.001)compared to American children.Stool unconjugated primary bile acids were inversely associated with weight-for-age[regression coefficient(β)=-0.01,P=0.01]and height-for-age Z scores(β=-0.01,P=0.03).Conjugated secondary bile acids were inversely associated with small intestine bacterial overgrowth(β=-1096.68,P=0.05).Fecal myeloperoxidase was associated with sulfated secondary bile acids(β=-0.40,P=0.04).Compared to 2-year-old children,the Bangladeshi infant’s serum had higher levels of unconjugated primary bile acids(65.23%vs 9.20%,P≤0.001)and lower levels of primary conjugated bile acids(0.69%vs 80.38%,P≤0.001).CONCLUSION Our data suggests an age-dependent defect in conjugation of primary bile acids in Bangladeshi children with compensatory hydrophilic shunting.Additionally,bile acid profiles are associated with intestinal overgrowth.
文摘BACKGROUND Gastrointestinal stromal tumors(GISTs)are rare mesenchymal tumors that rarely present with gastrointestinal(GI)bleeding due to tumor erosion.GISTs com-Core Tip:Gastrointestinal stromal tumors(GISTs)are rare mesenchymal tumors that rarely cause gastrointestinal(GI)bleeding.Mucosal ulceration and unfavorable tumor locations are risk factors for tumor progression and malignancy.We present a case of GI bleeding in a 42-year-old man complaining of melena over five days,which was diagnosed as a benign,ulcerated,jejunal GIST on histopathology and immunohistochemistry.Prompt evaluation using specialized diagnostic tools to locate obscure bleeding sources and complete surgical resection are key to favorable outcomes.GI bleeding in GIST is associated with a poor prognosis.Hence,detailed follow-ups are essential to detect and prevent tumor recurrence.INTRODUCTION Gastrointestinal stromal tumors(GISTs)are generally recognized as spindle cell,epithelioid,or occasionally pleomorphic tumors that usually develop in the gastrointestinal(GI)tract.Originating from mesenchymal cells of the GI tract,GISTs make up 1%-3%of all GI malignancies and progress to malignancy in approximately 10%to 30%of cases[1,2].A greater risk of tumor progression is linked to GISTs associated with mucosal ulceration and those that develop outside of the stomach[1,3].Many GISTs carry mutations in the genes encoding type III receptor tyrosine kinases,particularly KIT or PDGFRA,which is the case in up to 85%of instances.A significant majority,about 95%,of these tumors are positive for the KIT protein when tested with immunohistochemistry[4].The most common places where GIST arises are the stomach,followed by the small bowel[2].In 19%of cases,GISTs manifest asymptomatically,particularly in cases of smaller tumors of the intestinal tract.Studies show that around 10%of these cases were caught at autopsy and 20%during abdominal surgery for other conditions,making them a common incidental finding rather than a clinical suspicion[5,6].Patients who are symptomatic may exhibit non-specific symptoms such as nausea,vomiting,abdominal distension,early satiety,abdominal pain,and,in rare cases,a palpable abdominal mass.Obstruction of the GI lumen by endophytic growth or compression of the GI tract by exophytic growth may result in dysphagia,obstructive jaundice,or constipation in larger tumors,contingent upon the mass's specific location[1].Very rarely do these tumors present as an acute,severe,life-threatening GI bleeding[7].Herein,we describe a case report of a rather unusual presentation of GIST,i.e.,symptomatic GI bleeding caused by an ulcerated jejunal GIST,which was found to be benign in nature.This case report emphasizes the importance of maintaining a high suspicion of this disease when all routine workups for GI bleeding show no obvious findings.
文摘Metabolic dysfunction-associated steatotic liver disease is increasingly understood to be closely linked with skeletal muscle alterations,such as sarcopenia,myoste-atosis,and metabolic dysregulation,which play a key role in its pathogenesis and progression.Recent literature,including an article by Isakov,highlights the bidirectional interactions between muscle and liver,underscoring shared mechanisms such as insulin resistance,inflammation,and myokine imbalance.This letter reflects on key findings from the review,noting strengths such as its integration of mechanistic insights,discussion of emerging biomarkers,and emphasis on lifestyle and pharmacological interventions.It also identifies areas for further development,including standardization of diagnostic criteria and more rigorous evaluation of translational data.As muscle health gains promi-nence in metabolic dysfunction-associated steatotic liver disease research,multidisciplinary strategies that target both hepatic and muscular systems may offer more effective avenues for prevention and treatment.
文摘The buckling behavior of stiffened panels is significantly influenced by material and geometric defects,making it a critical factor in ensuring structural integrity and safety.These panels are widely used in mechanical,aerospace,marine,and civil engineering applications due to their ability to enhance bending stiffness with minimal additional weight.Under high loads or stress concentrations,localized structural failures can initiate global buckling in stiffened panels.This study investigates how such defects affect the critical buckling load,stiffness,and thickness of stiffened panels.Two finite element analyses were conducted:a linear analysis to identify the initial buckling mode and a nonlinear analysis using the Riks algorithm in Abaqus CAE,incorporating localized imperfections.The simulations show that material and geometric defects can reduce buckling resistance depending on their severity.
文摘Background:Community-acquired bacterial pneumonia(CABP)poses a serious public health threat,particularly with the emergence of drug-resistant bacterial strains.This study aims to investigate the molecular interactions of Nafithromycin(Miqnaf®),India’s first indigenous next-generation macrolide antibiotic,and evaluate its potential against Streptococcus pneumoniae,a key pathogen responsible for CABP.Targeting 23S rRNA is critical for overcoming antibiotic resistance since it is involved in bacterial protein production.Many antibiotics,including macrolides target this rRNA.Mutations in 23S rRNA frequently result in resistance;therefore,designing medicines that bind new or conserved areas of 23S rRNA can circumvent current resistance mechanisms and restore antibiotic potency.Nafithromycin has excellent therapeutic potential,with a short three-day regimen and much higher efficacy than conventional macrolides.Its high lung tissue penetration and robust effectiveness against drug-resistant respiratory bacteria make it a promising next-generation antibiotic.Methods:To elucidate the interaction of Nafithromycin with bacterial ribosomal RNA,molecular docking studies were performed using AutoDock Vina.The three-dimensional structure of Streptococcus pneumoniae 23S rRNA was retrieved from the Protein Data Bank(PDB).The ligand structure of Nafithromycin was obtained from the PubChem database and prepared using Open Babel.Docking simulations targeted key functional regions-Domains II and V of 23S rRNA-known to be critical for bacterial protein synthesis.Binding affinities were calculated,and molecular interactions such as hydrogen bonds,hydrophobic contacts,and conformational stabilities were analyzed using Discovery Studio and PyMOL.Results:Nafithromycin exhibited a high binding affinity of-10.3 kcal/mol toward S.pneumoniae 23S rRNA.The compound formed stable interactions with both Domain II and Domain V,crucial regions involved in the inhibition of bacterial protein synthesis.Hydrogen bonding and hydrophobic interactions further stabilized the ligand-receptor complex.Compared to azithromycin,Nafithromycin demonstrated superior binding efficacy and a greater potential to inhibit resistant bacterial strains,indicating its structural advantages and enhanced ribosomal targeting.Conclusion:Nafithromycin demonstrates significant potential as a potent therapeutic agent against drug-resistant CABP.Its strong binding affinity,stable interactions with bacterial rRNA,favorable pharmacokinetic profile,and reduced resistance risk support its clinical utility and suggest its advantage over traditional macrolide antibiotics such as azithromycin.
文摘Forests play a vital role in mitigating climate change through their physiological functions and metabolic processes,including their ability to convert solar energy into biomolecules.However,further research is necessary to elucidate how structural characteristics of a forest and topographic settings influence energy conversion and surface temperature of a forest.In this study,we investigated a beech forest in central Germany using airborne laser scanning(ALS)point cloud data and land surface temperature(LST)data derived from Landsat 9 satellite imagery.We constructed 30 m×30 m plots across the study area(approximately 17 km2)to align the spatial resolution of the satellite imagery with the ALS data.We analyzed topographic variables(surface elevation,aspect and slope),forest attributes(canopy cover,canopy height,and woody area index),as well as forest structural complexity,quantified by the box-dimension(Db).Our analysis revealed that LST is significantly influenced by both forest attributes and topographic variables.A multiple linear regression model demonstrated an inverse relationship(R^(2)=0.38,AIC=8105)between LST and a combination of Db,elevation,slope,and aspect.However,the model residuals exhibited significant spatial dependency,as indicated by Moran’s I test.To address this,we applied a spatial autoregressive model,which effectively accounted for spatial autocorrelation and improved the model fit(AIC=746).Our findings indicate that elevation exerts the most substantial influence on LST,followed by forest structural complexity,slope,and aspect.We conclude that forest management practices that enhance structural complexity can effectively reduce land surface temperatures in forested landscapes.
文摘The Arctic region is experiencing accelerated sea ice melt and increased iceberg detachment from glaciers due to climate change.These drifting icebergs present a risk and engineering challenge for subsea installations traversing shallow waters,where ice-berg keels may reach the seabed,potentially damaging subsea structures.Consequently,costly and time-intensive iceberg manage-ment operations,such as towing and rerouting,are undertaken to safeguard subsea and offshore infrastructure.This study,therefore,explores the application of extra tree regression(ETR)as a robust solution for estimating iceberg draft,particularly in the preliminary phases of decision-making for iceberg management projects.Nine ETR models were developed using parameters influencing iceberg draft.Subsequent analyses identified the most effective models and significant input variables.Uncertainty analysis revealed that the superior ETR model tended to overestimate iceberg drafts;however,it achieved the highest precision,correlation,and simplicity in estimation.Comparison with decision tree regression,random forest regression,and empirical methods confirmed the superior perfor-mance of ETR in predicting iceberg drafts.
基金supported by the National Natural Science Foundation of China(No.22278260)the Open Foundation of Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry(No.KFKT2021-14)Shaanxi Collaborative Innovation Center of Industrial Auxiliary Chemistry and Technology(No.KFKT2021-14).
文摘Aramid papers (AP), made of aramid fibers, demonstrate superiority in electrical insulation applications. Unfortunately, the strength and electrical insulating properties of AP remain suboptimal, primarily due to the smooth surface and chemical inertness of aramid fibers. Herein, AP are modified via the nacre-mimetic structure composed of aramid nanofibers (ANF) and carbonylated basalt nanosheets (CBSNs). This is achieved by impregnating AP into an ANF-CBSNs (A-C) suspension containing a 3D ANF framework as the matrix and 2D CBSNs as fillers. The resultant biomimetic composite papers (AP/A-C composite papers) exhibit a layered “brick-and-mortar” structure, demonstrating superior mechanical and electrical insulating properties. Notably, the tensile strength and breakdown strength of AP/A-C5 composite papers reach 39.69 MPa and 22.04 kV mm^(−1), respectively, representing a 155 % and 85 % increase compared to those of the control AP. These impressive properties are accompanied with excellent volume resistivity, exceptional dielectric properties, impressive folding endurance, outstanding heat insulation, and remarkable flame retardance. The nacre-inspired strategy offers an effective approach for producing highly promising electrical insulating papers for advanced electrical equipment.
基金supported by the government of the Republic of Korea(MSIT)and the National Research Foundation(NRF)of Korea(2022R1A2C1003900,2023K2A9A 1A01098512(FY2023)).
文摘TriboElectric NanoGenerators(TENGs),introduced in 2012 by Wang et al.,have revolutionized the way we harvest energy,converting mechanical energy into electrical power with remarkable efficiency.Since their inception,TENGs have unlocked innumerable applications,driving a surge in innovative research and development.This study utilizes the Scopus database to conduct a bibliographic analysis,highlighting the diverse applications,influential authors,and citation patterns that define the TENG landscape.Through the use of MATLAB and VOSviewer,we provide a visually compelling analysis that not only shows the integration of artificial intelligence in scientific literature but also explores the challenges and future potential of TENG technology.The document concludes by discussing TENGs challenges and the promising paths for their future applications.
