Ubiquitous energy-dense diets exacerbate the prevalence of metabolic syndrome across generations and increase cardiometabolic risks in offspring[1,2].This pervasive public health challenge has catalyzed intensive rese...Ubiquitous energy-dense diets exacerbate the prevalence of metabolic syndrome across generations and increase cardiometabolic risks in offspring[1,2].This pervasive public health challenge has catalyzed intensive research into the intricate regulation of energy substrate metabolism.展开更多
Increased accumulation of oxytetracycline(OTC)in environmental water bodies could potentially lead to its accumulation in human body,thereby damaging human intestinal tract.Dietary interventions could be helpful for r...Increased accumulation of oxytetracycline(OTC)in environmental water bodies could potentially lead to its accumulation in human body,thereby damaging human intestinal tract.Dietary interventions could be helpful for recovery of intestinal morphology and function.Therefore,this study set zebrafish as model to explore the potential of kefir supplementation in the recovery of intestinal damage caused by exposure to OTC.In experiments by zebrafish,the rearing units used were glass tanks,each with volume of 5 L.The tanks were stocked with 12 zebrafish each.For each treatment,there were 8 replicate tanks.The zebrafish were treated with OTC followed by the addition of kefir to the food.The results showed positive improvements with kefir supplementation.Kefir treatment mitigated intestinal inflammation by reducing the levels of TNF-α,IL-6,and IL-1β;enhancing the activity of the antioxidant enzymes catalase,superoxide dismutase,glutathione peroxidase and increasing the gene expression of intestinal tight junction proteins(ZO-1a and ZO-1b).These effects were beneficial for reversing reduced integrity of intestinal barrier caused by OTC.Moreover,kefir helped to reverse the disruption of gut microbiota caused by OTC and further impacted host metabolism.Specifically,Lactobacillus kefiranofaciens and Lactobacillus kefiri,which were derived from the kefir microbiota,were found to be enriched in the zebrafish intestine.This helped to inhibit the increased abundance of some Proteobacteria species induced by OTC treatment.Liver metabolomics analysis revealed that kefir improved OTC-induced disruptions in the tricarboxylic acid cycle,glycerophospholipid and amino acid metabolism.The differentially abundant metabolites identified included a total of 80 types after OTC exposure,with the abundance of 74 kinds significantly reversed following kefir treatment.Correlation analysis revealed that certain Proteobacteria species and above Lactobacillus species were closely linked with metabolic inhibition in zebrafish caused by OTC and metabolic restoration caused by kefir treatment,respectively.展开更多
The digestibility of cadmium(Cd)in brown rice is directly related to amino acid metabolism in rice and human health.In our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosag...The digestibility of cadmium(Cd)in brown rice is directly related to amino acid metabolism in rice and human health.In our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosages were applied to produce safe rice and improve the quality of rice in Cd-contaminated paddy.With the increased application of SIA,Cd content in iron plaque on rice root significantly increased,the transfer of Cd from rice root to grain significantly decreased,and then Cd content in brown rice decreased synchronously.The vitro digestibility of Cd in brown rice was estimated by a physiologically based extraction test.Results showed that more than 70%of Cd in brown rice could be digested by simulated gastrointestinal juice.Based on the total and digestible Cd contents in brown rice to evaluate the health risk,the application of 2.25 ton SIA/ha could produce safe rice in acidic slightly Cd-contaminated paddy soils.The amino acids(AAs)in brown rice were determined by high-performance liquid chromatography.The contents of 5 key AAs(KAAs)that actively respond to environmental changes increased significantly with the increased application of SIA.The structural equation model indicated that KAAs could be affected by the Cd translocation capacity from rice root to grain,and consequently altered the ratio of indigestible Cd in brown rice.The formation of indigestible KAAs-Cd complexes by combining KAAs(phenylalanine,leucine,histidine,glutamine,and asparagine)with Cd in brown rice could be considered a potential mechanism for reducing the digestibility of Cd.展开更多
Exploring high-efficiency and broadband microwave absorption(MA)materials with corrosion resistance and low cost is ur-gently needed for wide practical applications.Herein,the natural porous attapulgite(ATP)nanorods e...Exploring high-efficiency and broadband microwave absorption(MA)materials with corrosion resistance and low cost is ur-gently needed for wide practical applications.Herein,the natural porous attapulgite(ATP)nanorods embedded with TiO_(2)and polyaniline(PANI)nanoparticles are synthesized via heterogeneous precipitation and in-situ polymerization.The obtained PANI-TiO_(2)-ATP one-di-mensional(1D)nanostructures can intertwine into three-dimensional(3D)conductive network,which favors energy dissipation.The min-imum reflection loss(RL_(min))of the PANI-TiO_(2)-ATP coating(20wt%)reaches-49.36 dB at 9.53 GHz,and the effective absorption band-width(EAB)can reach 6.53 GHz with a thickness of 2.1 mm.The excellent MA properties are attributed to interfacial polarization,mul-tiple loss mechanisms,and good impedance matching induced by the synergistic effect of PANI-TiO_(2)nanoparticle shells and ATP nanor-ods.In addition,salt spray and Tafel polarization curve tests reveal that the PANI-TiO_(2)-ATP coating shows outstanding corrosion resist-ance performance.This study provides a low-cost and high-efficiency strategy for constructing 1D nanonetwork composites for MA and corrosion resistance applications using natural porous ATP nanorods as carriers.展开更多
Assessing the impact of anthropogenic volatile organic compounds(VOCs)on ozone(O_(3))formation is vital for themanagement of emission reduction and pollution control.Continuousmeasurement of O_(3)and the major precurs...Assessing the impact of anthropogenic volatile organic compounds(VOCs)on ozone(O_(3))formation is vital for themanagement of emission reduction and pollution control.Continuousmeasurement of O_(3)and the major precursorswas conducted in a typical light industrial city in the YRD region from 1 May to 25 July in 2021.Alkanes were the most abundant VOC group,contributing to 55.0%of TVOCs concentration(56.43±21.10 ppb).OVOCs,aromatics,halides,alkenes,and alkynes contributed 18.7%,9.6%,9.3%,5.2%and 1.9%,respectively.The observational site shifted from a typical VOC control regime to a mixed regime from May to July,which can be explained by the significant increase of RO_(x)production,resulting in the transition of environment from NOx saturation to radical saturation with respect to O_(3)production.The optimal O_(3)control strategy should be dynamically changed depending on the transition of control regime.Under NOx saturation condition,minimizing the proportion of NOx in reduction could lead to better achievement of O_(3)alleviation.Under mixed control regime,the cut percentage gets the top priority for the effectiveness of O_(3)control.Five VOCs sources were identified:temperature dependent source(28.1%),vehicular exhausts(19.9%),petrochemical industries(7.2%),solvent&gasoline usage(32.3%)and manufacturing industries(12.6%).The increase of temperature and radiation would enhance the evaporation related VOC emissions,resulting in the increase of VOC concentration and the change of RO_(x)circulation.Our results highlight determination of the optimal control strategies for O_(3)pollution in a typical YRD industrial city.展开更多
Nonreciprocal isolators enable unidirectional light propagation without back-reflection.Typical terahertz isolators require magnetic fields to break the time-reversal symmetry.Herein,we propose a nonmagnetic isolator ...Nonreciprocal isolators enable unidirectional light propagation without back-reflection.Typical terahertz isolators require magnetic fields to break the time-reversal symmetry.Herein,we propose a nonmagnetic isolator in the terahertz range based on nonreciprocal graphene plasmons operated in a reflection configuration.The bias voltage generates a drift current in graphene,which breaks the time-reversal symmetry and induces nonreciprocal reflection.The isolator device exhibited a high isolation exceeding 20 d B with an insertion loss of less than 3 d B.Moreover,the bandwidth wit isolation exceeding 20 d B can be broadened five times to 1.7 THz by tuning the carrier density.The indexes,including the isolation,insertion loss and bandwidth of the isolator,show a strong dependence on the drift velocity and mobility of graphene,as well as the air-gap thickness.Our study shows great potential in the burgeoning terahertz technology,where nonmagnetic and electrically tunable isolators are still lacking.展开更多
Tungsten heavy alloys(WHAs)prepared using laser additive manufacturing(AM)exhibit intricate ge-ometries,albeit with limited mechanical properties.Here we designed a high-strength WHA featuring a FeCrCoNi high entropy ...Tungsten heavy alloys(WHAs)prepared using laser additive manufacturing(AM)exhibit intricate ge-ometries,albeit with limited mechanical properties.Here we designed a high-strength WHA featuring a FeCrCoNi high entropy alloy(HEA)binder via the laser metal deposition(LMD)technique.Due to the distinctive thermal cycle and rapid cooling rate,the as-deposited alloys exhibit microstructures with hy-poeutectic,eutectic-like,and spot-like characteristics.To elucidate this phenomenon,the solidification paths were delineated and analyzed by combining microstructural characterization and phase equilib-rium simulation.Theμphase precipitated out from the supersaturated solid solution,thereby nucleating massive dislocations on the FeCrCoNi matrix to increase the work hardening rate.Furthermore,theμphase formed an ultrafine intermetallic compound(IMC)layer around the W grain,reducing the hole or crack between the W grain and FeCrCoNi matrix.Attributed to the precipitation strengthening,the solid solution of the FeCrCoNi binder,along with the load-bearing strength of W,the developed alloy achieved ultrahigh compressive stress and strain of 2047 MPa and 32%respectively at room temperature.These findings contribute valuable insights to the advancement of additive manufacturing for tungsten alloys,leveraging their excellent properties.展开更多
The successful control of hydrocarbon and CO emissions from low-temperature diesel exhausts requires the use of highly active co-oxidation catalysts.In this study,Sn was used to enhance the catalytic performance of Pd...The successful control of hydrocarbon and CO emissions from low-temperature diesel exhausts requires the use of highly active co-oxidation catalysts.In this study,Sn was used to enhance the catalytic performance of Pd/CeO_(2)in CO and C_(3)H_(6)co-oxidation conditions.CeO_(2)with added stannum(Sn)was prepared as a support using the co-precipitation method,and Pd was loaded onto the support using the impregnation method.After Sn addition(the optimal Ce/Sn ratio is 0.75:0.25),the T_(50)values of CO and C_(3)H_(6)are reduced by 20 and 32℃,respectively.A series of characterization methods indicates that the addition of Sn to the support greatly enhances its lattice oxygen mobility and increases the proportion of PdO.During the co-oxidation process,stronger lattice oxygen mobility allows CO to react faster through the Mars-van Krevelen mechanism,weakening the competition with C_(3)H_(6)for O_(2).A higher PdO content enhances the C_(3)H_(6)oxidation capability.Moreover,CO can more readily reduce PdO than Pd^(2+)in solid solution with the support,which consequently further enhances co-oxidation activity.Therefore,the addition of Sn is a simple and effective strategy for enhancing the performance of Pd/CeO_(2)catalysts in CO and C_(3)H_(6)co-oxidation reactions.Furthermore,the promotional effect of CO achieved in this study contributes to a deeper understanding of the interactions that occur during the co-oxidation of C_(3)H_(6)and CO.展开更多
This work investigates the transient performance and stability of CO_(2)/H_(2)O co-electrolysis in an air-free environment using a flat-tube solid oxide electrolysis cell(SOEC)stack.The results showed that the transie...This work investigates the transient performance and stability of CO_(2)/H_(2)O co-electrolysis in an air-free environment using a flat-tube solid oxide electrolysis cell(SOEC)stack.The results showed that the transient behavior of the stack with and without blowing gas into the air electrode is almost the same.With a current density of 0.67 A·cm^(-2)@750℃,the stack operated for over 200 h under co-electrolysis conditions without air blowing,and the voltage drop rate of the stack was approximately 0.203%/100 hours.Microstructure analysis revealed a significant loss of nickel particles and an apparent for-mation of an insulating phase strontium chromate(SrCrO4)on the surface of the current collection layer of the air electrode,which are identified as key factors contributing to the performance degradation of the stack.This study provides a reference for development of efficient fuel preparation technology based on SOEC stack in airless environments.展开更多
Attempts have been made to modulate motor sequence learning(MSL)through repetitive transcranial magnetic stimulation,targeting different sites within the sensorimotor network.However,the target with the optimum modula...Attempts have been made to modulate motor sequence learning(MSL)through repetitive transcranial magnetic stimulation,targeting different sites within the sensorimotor network.However,the target with the optimum modulatory effect on neural plasticity associated with MSL remains unclarified.This study was therefore designed to compare the role of the left primary motor cortex and the left supplementary motor area proper(SMAp)in modulating MSL across different complexity levels and for both hands,as well as the associated neuroplasticity by applying intermittent theta burst stimulation together with the electroencephalogram and concurrent transcranial magnetic stimulation.Our data demonstrated the role of SMAp stimulation in modulating neural communication to support MSL,which is achieved by facilitating regional activation and orchestrating neural coupling across distributed brain regions,particularly in interhemispheric connections.These findings may have important clinical implications,particularly for motor rehabilitation in populations such as post-stroke patients.展开更多
Objective INF2 is a member of the formins family.Abnormal expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(H...Objective INF2 is a member of the formins family.Abnormal expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(HCC)remain unclear.HCC is a highly lethal malignant tumor.Given the limitations of traditional treatments,this study explored the expression level,clinical value and potential mechanism of INF2 in HCC in order to seek new therapeutic targets.Methods In this study,we used public databases to analyze the expression of INF2 in pan-cancer and HCC,as well as the impact of INF2 expression levels on HCC prognosis.Quantitative real time polymerase chain reaction(RT-qPCR),Western blot,and immunohistochemistry were used to detect the expression level of INF2 in liver cancer cells and human HCC tissues.The correlation between INF2 expression and clinical pathological features was analyzed using public databases and clinical data of human HCC samples.Subsequently,the effects of INF2 expression on the biological function and Drp1 phosphorylation of liver cancer cells were elucidated through in vitro and in vivo experiments.Finally,the predictive value and potential mechanism of INF2 in HCC were further analyzed through database and immunohistochemical experiments.Results INF2 is aberrantly high expression in HCC samples and the high expression of INF2 is correlated with overall survival,liver cirrhosis and pathological differentiation of HCC patients.The expression level of INF2 has certain diagnostic value in predicting the prognosis and pathological differentiation of HCC.In vivo and in vitro HCC models,upregulated expression of INF2 triggers the proliferation and migration of the HCC cell,while knockdown of INF2 could counteract this effect.INF2 in liver cancer cells may affect mitochondrial division by inducing Drp1 phosphorylation and mediate immune escape by up-regulating PD-L1 expression,thus promoting tumor progression.Conclusion INF2 is highly expressed in HCC and is associated with poor prognosis.High expression of INF2 may promote HCC progression by inducing Drp1 phosphorylation and up-regulation of PD-L1 expression,and targeting INF2 may be beneficial for HCC patients with high expression of INF2.展开更多
Numerous studies have demonstrated that the high expression of CXC motif chemokine ligand 16(CXCL16)in cancer correlates with poor prognosis,as well as tumor cell proliferation,migration,and invasion.While CXCL16 can ...Numerous studies have demonstrated that the high expression of CXC motif chemokine ligand 16(CXCL16)in cancer correlates with poor prognosis,as well as tumor cell proliferation,migration,and invasion.While CXCL16 can serve as a tumor biomarker,the underlying mechanism in modulating head and neck squamous cell carcinoma(HNSCC)remains unclear.In this study,the aimed was to investigate the CXCL16 expression in HNSCC and to uncover the potential underlying mechanism.Hereby,we determined the high expression of CXCL16 in The Cancer Genome Atlas(TCGA)database,as well as in tissue samples from patients with HNSCC at our central hospital and from HNSCC cell lines.The results showed that CXCL16 knockdown inhibited the proliferation,migration,and invasion of HNSCC cells.Mechanistically,transcriptome sequencing revealed that CXCL16 may affect HNSCC cell growth by regulating the antioxidant pathway of glutathione peroxidase 1(GPX1).The reactive oxygen species(ROS)levels were elevated in small interfering CXCL16(si-CXCL16)cells,which may contribute to the inhibition of cell proliferation,migration,and invasion.Moreover,treatment of cells with the GPX1 inhibitor eldecalcitol(ED-71)revealed that HNSCC cell growth was significantly inhibited in the synergistic group of si-CXCL16 and GPX1 inhibitor compared to the si-CXCL16 group.In conclusion,CXCL16 contributed to the development of HNSCC cells by modulating the GPX1-mediated antioxidant pathway.Thus,targeting cellular CXCL16 expression seems to be a promising strategy for treating HNSCC.展开更多
Lirispirolides A−L(1−12),twelve novel sesquiterpene-monoterpene heterodimers featuring distinctive carbon skeletons,were isolated from the branches and leaves of Chinese tulip tree[Liriodendron chinense(L.chinense)],a...Lirispirolides A−L(1−12),twelve novel sesquiterpene-monoterpene heterodimers featuring distinctive carbon skeletons,were isolated from the branches and leaves of Chinese tulip tree[Liriodendron chinense(L.chinense)],a rare medicinal and ornamental plant endemic to China.The structural elucidation was accomplished through comprehensive spectroscopic analyses,quantum-chemical calculations,and X-ray crystallography.These heterodimers exhibit a characteristic 2-oxaspiro[4.5]decan-1-one structural motif,biosynthetically formed through intermolecular[4+2]-cycloaddition between a germacrane-type sesquiterpene and an ocimene-type monoterpene.The majority of the isolated compounds demonstrated significant anti-neuroinflammatory effects in lipopolysaccharide(LPS)-induced BV-2 microglial cells by reducing the production of pro-inflammatory mediators,specifically tumor necrosis factor-α(TNF-α)and nitric oxide(NO).Further investigation revealed that the lirispirolides’inhibition of NO release correlated with decreased messenger ribonucleic acid(mRNA)expression of inducible NO synthase(iNOS).展开更多
The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost ...The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost toxic cyanotoxin,microcystin-LR(MC-LR)enter soil via runoff,irrigated surface water and sewage,and the application of cyanobacterial biofertilizers as part of the sustainable agricultural practice.Earthworms in such remediation systems must sustain the potential risk from both nZVI and MC-LR.In the present study,earthworms(Eisenia fetida)were exposed up to 14 days to MC-LR and nZVI(individually and inmixture),and the toxicity was investigated at both the organismal andmetabolic levels,including growth,tissue damage,oxidative stress,metabolic response and gut microbiota.Results showed that co-exposure of MC-LR and nZVI is less potent to earthworms than that of separate exposure.Histological observations in the co-exposure group revealed only minor epidermal brokenness,and KEGG enrichment analysis showed that co-exposure induced earthworms to regulate glutathione biosynthesis for detoxification and reduced adverse effects from MC-LR.The combined use of nZVI promoted the growth and reproduction of soil and earthworm gut bacteria(e.g.,Sphingobacterium and Acinetobacter)responsible for the degradation of MC-LR,whichmight explain the observed antagonism between nZVI and MC-LR in earthworm microcosm.Our study suggests the beneficial use of nZVI to detoxify pollutants in earthworm-based vermiremediation systems where freshwater containing cyanobacterial blooms is frequently used to irrigate soil and supply water for the growth and metabolism of earthworms.展开更多
Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition wi...Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition with Random Forest algorithm to investigate ozone dynamics and formation regimes in a coastal area of China.During the period of 2017–2022,significant inter-annual fluctuations emerged,with peaks in mid-2017 attributed to volatile organic compounds(VOCs),and in late-2019 influenced by air temperature.Multifaceted periodicities(daily,weekly,holiday,and yearly)in ozone were revealed,elucidating substantial influences of daily and yearly components on ozone periodicity.A VOC-sensitive ozone formation regime was identified,characterized by lower VOCs/NO_(x) ratios(average=0.88)and significant positive correlations between ozone and VOCs.This interplay manifested in elevated ozone duringweekends,holidays,and pandemic lockdowns.Key variables influencing ozone across diverse timescaleswere uncovered,with solar radiation and temperature driving daily and yearly ozone variations,respectively.Precursor substances,particularly VOCs,significantly shaped weekly/holiday patterns and long-term trends of ozone.Specifically,acetone,ethane,hexanal,and toluene had a notable impact on the multi-year ozone trend,emphasizing the urgency of VOC regulation.Furthermore,our observations indicated that NO_(x) primarily drived the stochastic variations in ozone,a distinguishing characteristic of regions with heavy traffic.This research provides novel insights into ozone dynamics in coastal urban areas and highlights the importance of integrating statistical and machinelearning methods in atmospheric pollution studies,with implications for targeted mitigation strategies beyond this specific region and pollutant.展开更多
In this paper,we investigate the phenomena of electromagnetically induced transparency and the generation of second-order sideband in a Laguerre–Gaussian cavity optorotational system with a Kerr nonlinear medium.Usin...In this paper,we investigate the phenomena of electromagnetically induced transparency and the generation of second-order sideband in a Laguerre–Gaussian cavity optorotational system with a Kerr nonlinear medium.Using the perturbation method,we analyze the first-and second-order sideband generations in the output field from the system under the actions of a strong control field and a weak probe field.Numerical simulations show that the Kerr nonlinearity can lead to the occurrence of the asymmetric line shape in the transmission of the probe field.Comparing with traditional scheme for generating the second-order sideband,our spectral shape of the second-order sideband is amplified and becomes asymmetric,which has potential applications in precision measurement,high-sensitivity devices,and frequency conversion.展开更多
The traditional von Neumann architecture faces inherent limitations due to the separation of memory and computa-tion,leading to high energy consumption,significant latency,and reduced operational efficiency.Neuromorph...The traditional von Neumann architecture faces inherent limitations due to the separation of memory and computa-tion,leading to high energy consumption,significant latency,and reduced operational efficiency.Neuromorphic computing,inspired by the architecture of the human brain,offers a promising alternative by integrating memory and computational func-tions,enabling parallel,high-speed,and energy-efficient information processing.Among various neuromorphic technologies,ion-modulated optoelectronic devices have garnered attention due to their excellent ionic tunability and the availability of multi-dimensional control strategies.This review provides a comprehensive overview of recent progress in ion-modulation optoelec-tronic neuromorphic devices.It elucidates the key mechanisms underlying ionic modulation of light fields,including ion migra-tion dynamics and capture and release of charge through ions.Furthermore,the synthesis of active materials and the proper-ties of these devices are analyzed in detail.The review also highlights the application of ion-modulation optoelectronic devices in artificial vision systems,neuromorphic computing,and other bionic fields.Finally,the existing challenges and future direc-tions for the development of optoelectronic neuromorphic devices are discussed,providing critical insights for advancing this promising field.展开更多
The repeated volume variation of lithium(Li)metal anode(LMA)upon Li^(+) plating/stripping,the volatile interface between Li and the electrolyte,and the incessant growth of Li dendrites on Li metal surface have severel...The repeated volume variation of lithium(Li)metal anode(LMA)upon Li^(+) plating/stripping,the volatile interface between Li and the electrolyte,and the incessant growth of Li dendrites on Li metal surface have severely hindered the practical application of Li in constructing high energy-density Li metal batteries(LMBs).Herein,a novel Li host(3D ZnO/CNTs/Cu)featuring ordered microchannels and lithiophilic ZnO species on the inner walls of the microchannels is introduced,which induces the uniform Li^(+) deposition into the microchannels and finally suppresses the formation of Li dendrites.The stable structure of the fabricated 3D Li host can adapt to volume variations upon Li^(+) plating/stripping,thereby enhancing electrochemical performances.Symmetric cells with the 3D ZnO/CNTs/Cu@Li anode exhibited long cycle stability at areal current densities of 0.5 and 2 mA cm^(-2);Full cells maintained a reversible discharge capacity of 105 mAh g^(-1) after 400 cycles at 1C with a capacity retention of 70%.Meanwhile,ex-situ SEM observations proved that the 3D ZnO/CNTs/Cu@Li anode can keep the structural integrity during charging/discharging(or plating/stripping).This work suggested that lithiophilic nanochannels in the Li host can significantly improve the electrochemical performance and safety of LMBs.展开更多
A 12-metal Zn(Ⅱ)-Nd(Ⅲ) cluster 1(sizes:1.8 nm×2.0 nm×2.0 nm) was synthesized from a long-chain type Schiff base ligand.It displays ratiometric fluorescence response to neopterin(Neo) with high selectivity ...A 12-metal Zn(Ⅱ)-Nd(Ⅲ) cluster 1(sizes:1.8 nm×2.0 nm×2.0 nm) was synthesized from a long-chain type Schiff base ligand.It displays ratiometric fluorescence response to neopterin(Neo) with high selectivity and sensitivity,which can be expressed by the equation I_(545)_(nm)/I_(1060)_(nm)=A·[Neo]^(2)+B·[Neo]+C.1 is used to quantitatively test Neo concentrations in fetal calf serum(FCS) and urine,and the recovery ranges are 98.57%-103.82% and 99.25%-103.50%,respectively,while the relative standard deviations(RSDs) are 7.89%-9.46% and 1.85%-4.16%,respectively.The limits of detection of 1 to Neo in FCS and urine are 0.034 and 0.021 μmol/L,respectively.展开更多
Natural products(NPs)derived from plants,microbes,and marine organisms have historically been a cornerstone of pharmacotherapy,accounting for approximately 35%of FDA-approved small-molecule drugs since 19811.These com...Natural products(NPs)derived from plants,microbes,and marine organisms have historically been a cornerstone of pharmacotherapy,accounting for approximately 35%of FDA-approved small-molecule drugs since 19811.These compounds have been instrumental in drug discovery,particularly for cancer and infectious diseases,as well as in other therapeutic areas such as cardiovascular diseases(e.g.,statins)and multiple sclerosis(e.g.,fingolimod).展开更多
基金supported by grants from the National Natural Science Foundation of China(32400841)the China Postdoctoral Science Foundation(2023M743143).
文摘Ubiquitous energy-dense diets exacerbate the prevalence of metabolic syndrome across generations and increase cardiometabolic risks in offspring[1,2].This pervasive public health challenge has catalyzed intensive research into the intricate regulation of energy substrate metabolism.
基金financially supported by the Zhejiang Zhongmengchang Health Technology Co.,Ltd.
文摘Increased accumulation of oxytetracycline(OTC)in environmental water bodies could potentially lead to its accumulation in human body,thereby damaging human intestinal tract.Dietary interventions could be helpful for recovery of intestinal morphology and function.Therefore,this study set zebrafish as model to explore the potential of kefir supplementation in the recovery of intestinal damage caused by exposure to OTC.In experiments by zebrafish,the rearing units used were glass tanks,each with volume of 5 L.The tanks were stocked with 12 zebrafish each.For each treatment,there were 8 replicate tanks.The zebrafish were treated with OTC followed by the addition of kefir to the food.The results showed positive improvements with kefir supplementation.Kefir treatment mitigated intestinal inflammation by reducing the levels of TNF-α,IL-6,and IL-1β;enhancing the activity of the antioxidant enzymes catalase,superoxide dismutase,glutathione peroxidase and increasing the gene expression of intestinal tight junction proteins(ZO-1a and ZO-1b).These effects were beneficial for reversing reduced integrity of intestinal barrier caused by OTC.Moreover,kefir helped to reverse the disruption of gut microbiota caused by OTC and further impacted host metabolism.Specifically,Lactobacillus kefiranofaciens and Lactobacillus kefiri,which were derived from the kefir microbiota,were found to be enriched in the zebrafish intestine.This helped to inhibit the increased abundance of some Proteobacteria species induced by OTC treatment.Liver metabolomics analysis revealed that kefir improved OTC-induced disruptions in the tricarboxylic acid cycle,glycerophospholipid and amino acid metabolism.The differentially abundant metabolites identified included a total of 80 types after OTC exposure,with the abundance of 74 kinds significantly reversed following kefir treatment.Correlation analysis revealed that certain Proteobacteria species and above Lactobacillus species were closely linked with metabolic inhibition in zebrafish caused by OTC and metabolic restoration caused by kefir treatment,respectively.
基金supported by the National Key R&D Program of China (No.2019YFC1803704)。
文摘The digestibility of cadmium(Cd)in brown rice is directly related to amino acid metabolism in rice and human health.In our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosages were applied to produce safe rice and improve the quality of rice in Cd-contaminated paddy.With the increased application of SIA,Cd content in iron plaque on rice root significantly increased,the transfer of Cd from rice root to grain significantly decreased,and then Cd content in brown rice decreased synchronously.The vitro digestibility of Cd in brown rice was estimated by a physiologically based extraction test.Results showed that more than 70%of Cd in brown rice could be digested by simulated gastrointestinal juice.Based on the total and digestible Cd contents in brown rice to evaluate the health risk,the application of 2.25 ton SIA/ha could produce safe rice in acidic slightly Cd-contaminated paddy soils.The amino acids(AAs)in brown rice were determined by high-performance liquid chromatography.The contents of 5 key AAs(KAAs)that actively respond to environmental changes increased significantly with the increased application of SIA.The structural equation model indicated that KAAs could be affected by the Cd translocation capacity from rice root to grain,and consequently altered the ratio of indigestible Cd in brown rice.The formation of indigestible KAAs-Cd complexes by combining KAAs(phenylalanine,leucine,histidine,glutamine,and asparagine)with Cd in brown rice could be considered a potential mechanism for reducing the digestibility of Cd.
基金support from the National Key Research and Development Program of China(No.2021YFB3701503)the Key Research and Development Program of Ningbo,China(No.2023Z107)+1 种基金the Jiangsu Key R&D program,China(No.BE2019072)the special project of Gansu regional science and technology cooperation,China(No.20JR10 QA579).
文摘Exploring high-efficiency and broadband microwave absorption(MA)materials with corrosion resistance and low cost is ur-gently needed for wide practical applications.Herein,the natural porous attapulgite(ATP)nanorods embedded with TiO_(2)and polyaniline(PANI)nanoparticles are synthesized via heterogeneous precipitation and in-situ polymerization.The obtained PANI-TiO_(2)-ATP one-di-mensional(1D)nanostructures can intertwine into three-dimensional(3D)conductive network,which favors energy dissipation.The min-imum reflection loss(RL_(min))of the PANI-TiO_(2)-ATP coating(20wt%)reaches-49.36 dB at 9.53 GHz,and the effective absorption band-width(EAB)can reach 6.53 GHz with a thickness of 2.1 mm.The excellent MA properties are attributed to interfacial polarization,mul-tiple loss mechanisms,and good impedance matching induced by the synergistic effect of PANI-TiO_(2)nanoparticle shells and ATP nanor-ods.In addition,salt spray and Tafel polarization curve tests reveal that the PANI-TiO_(2)-ATP coating shows outstanding corrosion resist-ance performance.This study provides a low-cost and high-efficiency strategy for constructing 1D nanonetwork composites for MA and corrosion resistance applications using natural porous ATP nanorods as carriers.
基金supported by the National Natural Science Foundation of China(Nos.42005086,91844301,and 41805100)the National Key Research and Development Programof China(No.2022YFC3703500)+2 种基金China Postdoctoral Science Foundation(No.2023M733028)the Key Research and Development Program of Zhejiang Province(Nos.2021C03165 and 2022C03084)the Ecological and Environmental Scientific Research and Achievement Promotion Project of Zhejiang Province(No.2020HT0048).
文摘Assessing the impact of anthropogenic volatile organic compounds(VOCs)on ozone(O_(3))formation is vital for themanagement of emission reduction and pollution control.Continuousmeasurement of O_(3)and the major precursorswas conducted in a typical light industrial city in the YRD region from 1 May to 25 July in 2021.Alkanes were the most abundant VOC group,contributing to 55.0%of TVOCs concentration(56.43±21.10 ppb).OVOCs,aromatics,halides,alkenes,and alkynes contributed 18.7%,9.6%,9.3%,5.2%and 1.9%,respectively.The observational site shifted from a typical VOC control regime to a mixed regime from May to July,which can be explained by the significant increase of RO_(x)production,resulting in the transition of environment from NOx saturation to radical saturation with respect to O_(3)production.The optimal O_(3)control strategy should be dynamically changed depending on the transition of control regime.Under NOx saturation condition,minimizing the proportion of NOx in reduction could lead to better achievement of O_(3)alleviation.Under mixed control regime,the cut percentage gets the top priority for the effectiveness of O_(3)control.Five VOCs sources were identified:temperature dependent source(28.1%),vehicular exhausts(19.9%),petrochemical industries(7.2%),solvent&gasoline usage(32.3%)and manufacturing industries(12.6%).The increase of temperature and radiation would enhance the evaporation related VOC emissions,resulting in the increase of VOC concentration and the change of RO_(x)circulation.Our results highlight determination of the optimal control strategies for O_(3)pollution in a typical YRD industrial city.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11934011 and 12274365)National Key R&D Program of China(Grant Nos.2022YFA1402400 and 2022YFA1400043)+1 种基金Zhejiang Provincial Natural Science Foundation of China(Grant No.LR24A040001)Open project of Key Laboratory of Artificial Structures and Quantum Control(Ministry of Education)of Shanghai Jiao Tong University。
文摘Nonreciprocal isolators enable unidirectional light propagation without back-reflection.Typical terahertz isolators require magnetic fields to break the time-reversal symmetry.Herein,we propose a nonmagnetic isolator in the terahertz range based on nonreciprocal graphene plasmons operated in a reflection configuration.The bias voltage generates a drift current in graphene,which breaks the time-reversal symmetry and induces nonreciprocal reflection.The isolator device exhibited a high isolation exceeding 20 d B with an insertion loss of less than 3 d B.Moreover,the bandwidth wit isolation exceeding 20 d B can be broadened five times to 1.7 THz by tuning the carrier density.The indexes,including the isolation,insertion loss and bandwidth of the isolator,show a strong dependence on the drift velocity and mobility of graphene,as well as the air-gap thickness.Our study shows great potential in the burgeoning terahertz technology,where nonmagnetic and electrically tunable isolators are still lacking.
基金financially suppoted by the National Natural Sci-ence Foundation of China(No.52371041).
文摘Tungsten heavy alloys(WHAs)prepared using laser additive manufacturing(AM)exhibit intricate ge-ometries,albeit with limited mechanical properties.Here we designed a high-strength WHA featuring a FeCrCoNi high entropy alloy(HEA)binder via the laser metal deposition(LMD)technique.Due to the distinctive thermal cycle and rapid cooling rate,the as-deposited alloys exhibit microstructures with hy-poeutectic,eutectic-like,and spot-like characteristics.To elucidate this phenomenon,the solidification paths were delineated and analyzed by combining microstructural characterization and phase equilib-rium simulation.Theμphase precipitated out from the supersaturated solid solution,thereby nucleating massive dislocations on the FeCrCoNi matrix to increase the work hardening rate.Furthermore,theμphase formed an ultrafine intermetallic compound(IMC)layer around the W grain,reducing the hole or crack between the W grain and FeCrCoNi matrix.Attributed to the precipitation strengthening,the solid solution of the FeCrCoNi binder,along with the load-bearing strength of W,the developed alloy achieved ultrahigh compressive stress and strain of 2047 MPa and 32%respectively at room temperature.These findings contribute valuable insights to the advancement of additive manufacturing for tungsten alloys,leveraging their excellent properties.
基金Project supported by the National Key R&D Program of China(2022YFC3701804)the National Natural Science Foundation of China(52225004)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA23010201)the Youth Innovation Promotion Association of Chinese Academy of Sciences(2022309)。
文摘The successful control of hydrocarbon and CO emissions from low-temperature diesel exhausts requires the use of highly active co-oxidation catalysts.In this study,Sn was used to enhance the catalytic performance of Pd/CeO_(2)in CO and C_(3)H_(6)co-oxidation conditions.CeO_(2)with added stannum(Sn)was prepared as a support using the co-precipitation method,and Pd was loaded onto the support using the impregnation method.After Sn addition(the optimal Ce/Sn ratio is 0.75:0.25),the T_(50)values of CO and C_(3)H_(6)are reduced by 20 and 32℃,respectively.A series of characterization methods indicates that the addition of Sn to the support greatly enhances its lattice oxygen mobility and increases the proportion of PdO.During the co-oxidation process,stronger lattice oxygen mobility allows CO to react faster through the Mars-van Krevelen mechanism,weakening the competition with C_(3)H_(6)for O_(2).A higher PdO content enhances the C_(3)H_(6)oxidation capability.Moreover,CO can more readily reduce PdO than Pd^(2+)in solid solution with the support,which consequently further enhances co-oxidation activity.Therefore,the addition of Sn is a simple and effective strategy for enhancing the performance of Pd/CeO_(2)catalysts in CO and C_(3)H_(6)co-oxidation reactions.Furthermore,the promotional effect of CO achieved in this study contributes to a deeper understanding of the interactions that occur during the co-oxidation of C_(3)H_(6)and CO.
基金co-supported by the National Key R&D Program of China(No.2022YFB4002203)Baima Lake Laboratory Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(No.LBMHY24B060003)Ningbo Key R&D Project(No.2023Z155).
文摘This work investigates the transient performance and stability of CO_(2)/H_(2)O co-electrolysis in an air-free environment using a flat-tube solid oxide electrolysis cell(SOEC)stack.The results showed that the transient behavior of the stack with and without blowing gas into the air electrode is almost the same.With a current density of 0.67 A·cm^(-2)@750℃,the stack operated for over 200 h under co-electrolysis conditions without air blowing,and the voltage drop rate of the stack was approximately 0.203%/100 hours.Microstructure analysis revealed a significant loss of nickel particles and an apparent for-mation of an insulating phase strontium chromate(SrCrO4)on the surface of the current collection layer of the air electrode,which are identified as key factors contributing to the performance degradation of the stack.This study provides a reference for development of efficient fuel preparation technology based on SOEC stack in airless environments.
基金supported by grants from the Zhejiang Provincial Natural Science Foundation(LGJ22H180001)Zhejiang Medical and Health Science and Technology Project(2021KY249)the National Key R&D Program of China(2017YFC1310000).
文摘Attempts have been made to modulate motor sequence learning(MSL)through repetitive transcranial magnetic stimulation,targeting different sites within the sensorimotor network.However,the target with the optimum modulatory effect on neural plasticity associated with MSL remains unclarified.This study was therefore designed to compare the role of the left primary motor cortex and the left supplementary motor area proper(SMAp)in modulating MSL across different complexity levels and for both hands,as well as the associated neuroplasticity by applying intermittent theta burst stimulation together with the electroencephalogram and concurrent transcranial magnetic stimulation.Our data demonstrated the role of SMAp stimulation in modulating neural communication to support MSL,which is achieved by facilitating regional activation and orchestrating neural coupling across distributed brain regions,particularly in interhemispheric connections.These findings may have important clinical implications,particularly for motor rehabilitation in populations such as post-stroke patients.
文摘Objective INF2 is a member of the formins family.Abnormal expression and regulation of INF2 have been associated with the progression of various tumors,but the expression and role of INF2 in hepatocellular carcinoma(HCC)remain unclear.HCC is a highly lethal malignant tumor.Given the limitations of traditional treatments,this study explored the expression level,clinical value and potential mechanism of INF2 in HCC in order to seek new therapeutic targets.Methods In this study,we used public databases to analyze the expression of INF2 in pan-cancer and HCC,as well as the impact of INF2 expression levels on HCC prognosis.Quantitative real time polymerase chain reaction(RT-qPCR),Western blot,and immunohistochemistry were used to detect the expression level of INF2 in liver cancer cells and human HCC tissues.The correlation between INF2 expression and clinical pathological features was analyzed using public databases and clinical data of human HCC samples.Subsequently,the effects of INF2 expression on the biological function and Drp1 phosphorylation of liver cancer cells were elucidated through in vitro and in vivo experiments.Finally,the predictive value and potential mechanism of INF2 in HCC were further analyzed through database and immunohistochemical experiments.Results INF2 is aberrantly high expression in HCC samples and the high expression of INF2 is correlated with overall survival,liver cirrhosis and pathological differentiation of HCC patients.The expression level of INF2 has certain diagnostic value in predicting the prognosis and pathological differentiation of HCC.In vivo and in vitro HCC models,upregulated expression of INF2 triggers the proliferation and migration of the HCC cell,while knockdown of INF2 could counteract this effect.INF2 in liver cancer cells may affect mitochondrial division by inducing Drp1 phosphorylation and mediate immune escape by up-regulating PD-L1 expression,thus promoting tumor progression.Conclusion INF2 is highly expressed in HCC and is associated with poor prognosis.High expression of INF2 may promote HCC progression by inducing Drp1 phosphorylation and up-regulation of PD-L1 expression,and targeting INF2 may be beneficial for HCC patients with high expression of INF2.
基金supported by the Scientific Research Fund of the National Health Commission-Zhejiang Provincial Health Major Science and Technology Plan Project(No.WKJ-ZJ-2415)the Key Research and Development Program of Zhejiang Province(No.2024C03166)+1 种基金the Traditional Chinese Medicine Science and Technology Project of Zhejiang Province(No.2022ZB020)the Zhejiang Provincial Natural Science Foundation of China(No.LY21H160049).
文摘Numerous studies have demonstrated that the high expression of CXC motif chemokine ligand 16(CXCL16)in cancer correlates with poor prognosis,as well as tumor cell proliferation,migration,and invasion.While CXCL16 can serve as a tumor biomarker,the underlying mechanism in modulating head and neck squamous cell carcinoma(HNSCC)remains unclear.In this study,the aimed was to investigate the CXCL16 expression in HNSCC and to uncover the potential underlying mechanism.Hereby,we determined the high expression of CXCL16 in The Cancer Genome Atlas(TCGA)database,as well as in tissue samples from patients with HNSCC at our central hospital and from HNSCC cell lines.The results showed that CXCL16 knockdown inhibited the proliferation,migration,and invasion of HNSCC cells.Mechanistically,transcriptome sequencing revealed that CXCL16 may affect HNSCC cell growth by regulating the antioxidant pathway of glutathione peroxidase 1(GPX1).The reactive oxygen species(ROS)levels were elevated in small interfering CXCL16(si-CXCL16)cells,which may contribute to the inhibition of cell proliferation,migration,and invasion.Moreover,treatment of cells with the GPX1 inhibitor eldecalcitol(ED-71)revealed that HNSCC cell growth was significantly inhibited in the synergistic group of si-CXCL16 and GPX1 inhibitor compared to the si-CXCL16 group.In conclusion,CXCL16 contributed to the development of HNSCC cells by modulating the GPX1-mediated antioxidant pathway.Thus,targeting cellular CXCL16 expression seems to be a promising strategy for treating HNSCC.
基金supported by the National Natural Science Foundation of China(Nos.82373752 and 21937002)the Science and Technology Commission of Shanghai Municipality(No.22ZR1414400).
文摘Lirispirolides A−L(1−12),twelve novel sesquiterpene-monoterpene heterodimers featuring distinctive carbon skeletons,were isolated from the branches and leaves of Chinese tulip tree[Liriodendron chinense(L.chinense)],a rare medicinal and ornamental plant endemic to China.The structural elucidation was accomplished through comprehensive spectroscopic analyses,quantum-chemical calculations,and X-ray crystallography.These heterodimers exhibit a characteristic 2-oxaspiro[4.5]decan-1-one structural motif,biosynthetically formed through intermolecular[4+2]-cycloaddition between a germacrane-type sesquiterpene and an ocimene-type monoterpene.The majority of the isolated compounds demonstrated significant anti-neuroinflammatory effects in lipopolysaccharide(LPS)-induced BV-2 microglial cells by reducing the production of pro-inflammatory mediators,specifically tumor necrosis factor-α(TNF-α)and nitric oxide(NO).Further investigation revealed that the lirispirolides’inhibition of NO release correlated with decreased messenger ribonucleic acid(mRNA)expression of inducible NO synthase(iNOS).
基金supported by the National Natural Science Foundation of China(No.21777139)the National Key Research and Development Program of China(No.2017YFA0207003).
文摘The earthworm-based vermiremediation facilitated with benign chemicals such as nano zero-valent iron(nZVI)is a promising approach for the remediation of a variety of soil contaminants including cyanotoxins.As themost toxic cyanotoxin,microcystin-LR(MC-LR)enter soil via runoff,irrigated surface water and sewage,and the application of cyanobacterial biofertilizers as part of the sustainable agricultural practice.Earthworms in such remediation systems must sustain the potential risk from both nZVI and MC-LR.In the present study,earthworms(Eisenia fetida)were exposed up to 14 days to MC-LR and nZVI(individually and inmixture),and the toxicity was investigated at both the organismal andmetabolic levels,including growth,tissue damage,oxidative stress,metabolic response and gut microbiota.Results showed that co-exposure of MC-LR and nZVI is less potent to earthworms than that of separate exposure.Histological observations in the co-exposure group revealed only minor epidermal brokenness,and KEGG enrichment analysis showed that co-exposure induced earthworms to regulate glutathione biosynthesis for detoxification and reduced adverse effects from MC-LR.The combined use of nZVI promoted the growth and reproduction of soil and earthworm gut bacteria(e.g.,Sphingobacterium and Acinetobacter)responsible for the degradation of MC-LR,whichmight explain the observed antagonism between nZVI and MC-LR in earthworm microcosm.Our study suggests the beneficial use of nZVI to detoxify pollutants in earthworm-based vermiremediation systems where freshwater containing cyanobacterial blooms is frequently used to irrigate soil and supply water for the growth and metabolism of earthworms.
基金supported by Ningbo Natural Science Foundation(No.2023J059)Ningbo Commonweal Programme Key Project(No.2023S038)Guangxi Key Research and Development Programme(No.GuikeAB21220063).
文摘Machine-learning is a robust technique for understanding pollution characteristics of surface ozone,which are at high levels in urban China.This study introduced an innovative approach combining trend decomposition with Random Forest algorithm to investigate ozone dynamics and formation regimes in a coastal area of China.During the period of 2017–2022,significant inter-annual fluctuations emerged,with peaks in mid-2017 attributed to volatile organic compounds(VOCs),and in late-2019 influenced by air temperature.Multifaceted periodicities(daily,weekly,holiday,and yearly)in ozone were revealed,elucidating substantial influences of daily and yearly components on ozone periodicity.A VOC-sensitive ozone formation regime was identified,characterized by lower VOCs/NO_(x) ratios(average=0.88)and significant positive correlations between ozone and VOCs.This interplay manifested in elevated ozone duringweekends,holidays,and pandemic lockdowns.Key variables influencing ozone across diverse timescaleswere uncovered,with solar radiation and temperature driving daily and yearly ozone variations,respectively.Precursor substances,particularly VOCs,significantly shaped weekly/holiday patterns and long-term trends of ozone.Specifically,acetone,ethane,hexanal,and toluene had a notable impact on the multi-year ozone trend,emphasizing the urgency of VOC regulation.Furthermore,our observations indicated that NO_(x) primarily drived the stochastic variations in ozone,a distinguishing characteristic of regions with heavy traffic.This research provides novel insights into ozone dynamics in coastal urban areas and highlights the importance of integrating statistical and machinelearning methods in atmospheric pollution studies,with implications for targeted mitigation strategies beyond this specific region and pollutant.
基金supported by the National Natural Science Foundation of China(Grant Nos.12174344 and 12175199)Foundation of Department of Science and Technology of Zhejiang Province(Grant No.2022R52047)。
文摘In this paper,we investigate the phenomena of electromagnetically induced transparency and the generation of second-order sideband in a Laguerre–Gaussian cavity optorotational system with a Kerr nonlinear medium.Using the perturbation method,we analyze the first-and second-order sideband generations in the output field from the system under the actions of a strong control field and a weak probe field.Numerical simulations show that the Kerr nonlinearity can lead to the occurrence of the asymmetric line shape in the transmission of the probe field.Comparing with traditional scheme for generating the second-order sideband,our spectral shape of the second-order sideband is amplified and becomes asymmetric,which has potential applications in precision measurement,high-sensitivity devices,and frequency conversion.
基金supported by National Natural Science Foundation of China(62174164,U23A20568,and U22A2075)National Key Research and Development Project(2021YFA1202600)+2 种基金Talent Plan of Shanghai Branch,Chinese Academy of Sciences(CASSHB-QNPD-2023-022)Ningbo Technology Project(2022A-007-C)Ningbo Key Research and Development Project(2023Z021).
文摘The traditional von Neumann architecture faces inherent limitations due to the separation of memory and computa-tion,leading to high energy consumption,significant latency,and reduced operational efficiency.Neuromorphic computing,inspired by the architecture of the human brain,offers a promising alternative by integrating memory and computational func-tions,enabling parallel,high-speed,and energy-efficient information processing.Among various neuromorphic technologies,ion-modulated optoelectronic devices have garnered attention due to their excellent ionic tunability and the availability of multi-dimensional control strategies.This review provides a comprehensive overview of recent progress in ion-modulation optoelec-tronic neuromorphic devices.It elucidates the key mechanisms underlying ionic modulation of light fields,including ion migra-tion dynamics and capture and release of charge through ions.Furthermore,the synthesis of active materials and the proper-ties of these devices are analyzed in detail.The review also highlights the application of ion-modulation optoelectronic devices in artificial vision systems,neuromorphic computing,and other bionic fields.Finally,the existing challenges and future direc-tions for the development of optoelectronic neuromorphic devices are discussed,providing critical insights for advancing this promising field.
基金supported by the Science Foundation of Zhejiang Sci-Tech University(18062299-Y)。
文摘The repeated volume variation of lithium(Li)metal anode(LMA)upon Li^(+) plating/stripping,the volatile interface between Li and the electrolyte,and the incessant growth of Li dendrites on Li metal surface have severely hindered the practical application of Li in constructing high energy-density Li metal batteries(LMBs).Herein,a novel Li host(3D ZnO/CNTs/Cu)featuring ordered microchannels and lithiophilic ZnO species on the inner walls of the microchannels is introduced,which induces the uniform Li^(+) deposition into the microchannels and finally suppresses the formation of Li dendrites.The stable structure of the fabricated 3D Li host can adapt to volume variations upon Li^(+) plating/stripping,thereby enhancing electrochemical performances.Symmetric cells with the 3D ZnO/CNTs/Cu@Li anode exhibited long cycle stability at areal current densities of 0.5 and 2 mA cm^(-2);Full cells maintained a reversible discharge capacity of 105 mAh g^(-1) after 400 cycles at 1C with a capacity retention of 70%.Meanwhile,ex-situ SEM observations proved that the 3D ZnO/CNTs/Cu@Li anode can keep the structural integrity during charging/discharging(or plating/stripping).This work suggested that lithiophilic nanochannels in the Li host can significantly improve the electrochemical performance and safety of LMBs.
基金Project supported by the National Natural Science Foundation of China (21771141)。
文摘A 12-metal Zn(Ⅱ)-Nd(Ⅲ) cluster 1(sizes:1.8 nm×2.0 nm×2.0 nm) was synthesized from a long-chain type Schiff base ligand.It displays ratiometric fluorescence response to neopterin(Neo) with high selectivity and sensitivity,which can be expressed by the equation I_(545)_(nm)/I_(1060)_(nm)=A·[Neo]^(2)+B·[Neo]+C.1 is used to quantitatively test Neo concentrations in fetal calf serum(FCS) and urine,and the recovery ranges are 98.57%-103.82% and 99.25%-103.50%,respectively,while the relative standard deviations(RSDs) are 7.89%-9.46% and 1.85%-4.16%,respectively.The limits of detection of 1 to Neo in FCS and urine are 0.034 and 0.021 μmol/L,respectively.
文摘Natural products(NPs)derived from plants,microbes,and marine organisms have historically been a cornerstone of pharmacotherapy,accounting for approximately 35%of FDA-approved small-molecule drugs since 19811.These compounds have been instrumental in drug discovery,particularly for cancer and infectious diseases,as well as in other therapeutic areas such as cardiovascular diseases(e.g.,statins)and multiple sclerosis(e.g.,fingolimod).
