A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anod...A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anode dissolution kinetics.A Mg-air battery prepared using this anode exhibits a cell voltage of 1.626 V at 0.5 mA/cm^(2),reasonable anodic efficiency of 58.17%,and good specific energy of 1730.96 mW·h/g at 10 mA/cm^(2).This performance is attributed to the effective reactive anode surface,the suppressed chunk effect,and weak self-corrosion owing to the homogeneous basal texture.展开更多
The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconci...The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.展开更多
The recent commercialization of gene products has sparked significant interest in gene therapy,necessitating efficient and precise gene delivery via various vectors.Currently,viral vectors and lipid-based nanocarriers...The recent commercialization of gene products has sparked significant interest in gene therapy,necessitating efficient and precise gene delivery via various vectors.Currently,viral vectors and lipid-based nanocarriers are the predominant choices and have been extensively investigated and reviewed.Beyond these vectors,polymeric nanocarriers also hold the promise in therapeutic gene delivery owing to their versatile functionalities,such as improving the stability,cellar uptake and endosomal escape of nucleic acid drugs,along with precise delivery to targeted tissues.This review presents a brief overview of the status quo of the emerging polymeric nanocarriers for therapeutic gene delivery,focusing on key cationic polymers,nanocarrier types,and preparation methods.It also highlights targeted diseases,strategies to improve delivery efficiency,and potential future directions in this research area.The review is hoped to inspire the development,optimization,and clinical translation of highly efficient polymeric nanocarriers for therapeutic gene delivery.展开更多
BACKGROUND: Sepsis, a common acute and critical disease, leads to 11 million deaths annually worldwide. Probiotics are living microorganisms that are beneficial to the host and may benefit sepsis outcomes, but their e...BACKGROUND: Sepsis, a common acute and critical disease, leads to 11 million deaths annually worldwide. Probiotics are living microorganisms that are beneficial to the host and may benefit sepsis outcomes, but their effects are stil inconclusive. This study aimed to evaluate the overal eff ect of probiotics on the prognosis of patients with sepsis.DATA RESOURCES: We searched several sources for published/presented studies, including Pub Med, EMBASE, Web of Science, the Cochrane Library and the US National Library of Medicine Clinical Trials Register(www.clinicaltrials.gov) updated through July 30, 2023, to identify all relevant randomized controlled trials(RCTs) or observational studies that assessed the effectiveness of probiotics or synbiotics in patients with sepsis and reported mortality. We focused primarily on mortality during the study period and analyzed secondary outcomes, including 28-day mortality, in-intensive care unit(ICU) mortality and other outcomes.RESULTS: Data from 405 patients in five RCTs and 108 patients in one cohort study were included in the analysis. The overall quality of the studies was satisfactory, but clinical heterogeneity existed. All adult studies reported a tendency for probiotics to reduce the mortality of patients with sepsis, and most studies reported a decreasing trend in the incidence of infectious complications, length of ICU stay and duration of antibiotic use. There was only one RCT involving children.CONCLUSION: Probiotics show promise for improving the prognosis of patients with sepsis, including reducing mortality and the incidence of infectious complications, particularly in adult patients. Despite the limited number of studies, especially in children, these findings will be encouraging for clinical practice in the treatment of sepsis and suggest that gut microbiota-targeted therapy may improve the prognosis of patients with sepsis.展开更多
The sources and accumulation of heavy metals in soil are of great significance for soil utilization and pollution control.Lead(Pb),a common heavy metal element,tends to accumulate in the soils with time.Excess Pb in s...The sources and accumulation of heavy metals in soil are of great significance for soil utilization and pollution control.Lead(Pb),a common heavy metal element,tends to accumulate in the soils with time.Excess Pb in soils accumulates in plants and becomes toxic to humans and livestock when it enters the food chain.The historical data of Pb contents in soils in northwest China were stud-ied to establish the historical change curve in this paper.The results indicate geochemical background and wind and dust deposition have the minor contribution to the accumulation of Pb in soils,but human activities have caused a rapid accumulation of Pb in soils.From 1990 to 2020,the accumulation of about 0.1 mg/kg of Pb in the soils is due to natural wind-dust deposits,but the content of Pb in the soils has nearly tripled from about 22 mg/kg to about 52 mg/kg with the process of anthropogenic urbanization and industrialization.We found that the influence of human activities on lead content was closely related to the total primary energy production(10,000 tons of SCE),and the evolution of soil Pb contents in the study area was consis-tent with the Allometric1 model.展开更多
Up to now,“Turn-on”fluorescence sensor exhibits promising potential toward the detection of heavy metal ions,anions,drugs,organic dyes,DNA,pesticides,and other amino acids due to their simple,quick detection,and hig...Up to now,“Turn-on”fluorescence sensor exhibits promising potential toward the detection of heavy metal ions,anions,drugs,organic dyes,DNA,pesticides,and other amino acids due to their simple,quick detection,and high sensitivity and selectivity.Herein,a novel fluorescence method of detecting Cr^(3+)in an aqueous solution was described based on the fluorescence resonance energy transfer between rhodamine B(Rh B)and gold nanoparticles(Au NPs).The fluorescence of Rh B solution could be obviously quenched(“off”state)with the presence of citrate-stabilized Au NPs.However,upon addition of Cr^(3+)to Au NPs@Rh B system,the fluorescence of Au NPs was recovered owing to the strong interaction between Cr^(3+)and the specific groups on the surface of citrate-stabilized Au NPs,which will lead to the aggregation of Au NPs(“on”state).At this point,the color of the reaction solution turned to black.Under optimal conditions,the limit of detection(LOD)for Cr^(3+)was 0.95 n M(signal-to-noise ratio,S/N=3)with a linear range of 0.164 n M to 3.270μM.Furthermore,the proposed method exhibits excellent performances,such as rapid analysis,high sensitivity,extraordinary selectivity,easy preparation,switch-on fluorescence response,and non-time consuming.展开更多
BACKGROUND At present,prophylactic ileostomy is commonly used to protect distal intestinal anastomoses,particularly during the recovery period following colorectal surgery.However,after the ileum is returned to the ab...BACKGROUND At present,prophylactic ileostomy is commonly used to protect distal intestinal anastomoses,particularly during the recovery period following colorectal surgery.However,after the ileum is returned to the abdominal cavity,abdominal closure using traditional vertical interrupted suturing is associated with a higher incidence of wound infections.For patients undergoing ileostomy closure,selecting an appropriate suturing method for the skin incision at the stoma site is crucial for improving patient prognosis.AIM To investigate the impact of three different skin suturing methods at the ileostomy closure site on patient prognosis.METHODS Thirty patients who underwent ileostomy closure at the Affiliated Hospital of Qinghai University between January 2024 and October 2024 were selected based on inclusion and exclusion criteria.The patients were divided into three groups:The purse-string suture group,the cross-suture group,and the vertical interrupted suture group,with 10 cases in each group.The purse-string suture group,cross-suture group,and vertical interrupted suture group used purse-string,cross,and vertical interrupted suturing methods,respectively,for the skin incision at the ileostomy closure site.RESULTS There were no statistically significant differences among the three groups in terms of operative time,intraoperative blood loss,time to resume liquid diet,time to first bowel movement,postoperative hospital stay,hospitalization costs,or levels of white blood cell count,hemoglobin,and albumin on the third postoperative day(P>0.05).Nevertheless,significant differences(P<0.05)were observed in incision suture removal time,wound healing time,C-reactive protein levels on the third postoperative day,visual analog scale pain scores during the first three postoperative days,and the incidence of surgical site infection.Overall,the therapeutic outcomes of the pursestring suture group and the cross-suture group were superior to the vertical interrupted suture group.CONCLUSION Using purse-string or cross-suturing methods for skin incision at the ileostomy closure site can shorten wound healing and suture removal times,reduce surgical site infection incidence and postoperative inflammatory response,alleviate incision pain,and promote rapid postoperative recovery.展开更多
We editorialized on this study published by Zou et al.Gastrointestinal bleeding is a common clinical symptom,and hemocoagulase is frequently used to treat hemorrhagic conditions.However,studies have shown that hemocoa...We editorialized on this study published by Zou et al.Gastrointestinal bleeding is a common clinical symptom,and hemocoagulase is frequently used to treat hemorrhagic conditions.However,studies have shown that hemocoagulase treatment may induce acquired hypofibrinogenemia,further aggravating the bleeding.Zou et al retrospectively analyzed 109 gastrointestinal bleeding cases to explore the hazards underlying hypofibrinogenemia induced by hemocoagulase,and identified higher total dose of hemocoagulase and female sex,as well as low baseline fibrinogen levels as significant hazards.Consequently,clinicians should be aware of both intrinsic and extrinsic risk factors when using hemocoagulase among this patient population,and remain vigilant for the potential development of hemocoagulase-induced hypofibrinogenemia.展开更多
The widespread popularization and application of laser technology have provided a powerful tool for a deeper understanding of the material world and given birth to several emerging research fields.This study mainly fo...The widespread popularization and application of laser technology have provided a powerful tool for a deeper understanding of the material world and given birth to several emerging research fields.This study mainly focuses on the following three key aspects.First,the classical ensemble method is adopted to conduct a comprehensive and in-depth analysis of two-dimensional(2D)matter–wave pulses in Bose–Fermi mixed gases(including linear and nonlinear pulses).Second,under the strict constraints of unitary systems,a coupled Kd V equation is successfully derived,and the prolongation structure theory is skillfully used to carry out detailed calculations and analyses on this equation.Thus,the prolongation algebra of this equation is accurately determined,and the corresponding Lax pair is rigorously derived.Finally,based on the carefully obtained Lax pair from the prolongation structure theory,the soliton solutions of this equation are further analyzed in depth,and intuitive images of each soliton solution are carefully drawn.This lays a solid foundation for subsequent detailed research on these soliton characteristics and provides great convenience.展开更多
The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction...The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction(SCR)has the potential to achieve ultra-low NO_(x) emissions,several challenges remain,including the accurate prediction of ammonia(NH_(3))storage mass and the co-control of the two-stage SCR.The first step in this study involved the establishment of a rapid control prototype platform to facilitate the development and validation of a two-stage SCR control strategy.Secondly,an initial method for predicting the NH_(3) storage based on the mass conservation law was proposed,which was subsequently improved by filling and emptying experiments.The third step involved the development of a two-stage SCR co-control strategy,including obtaining the steady-state NH_(3) storage target value,dynamic correction for NH_(3) storage target value,regulation of NH_(3) storage,and control of the close-coupled SCR urea injector state.Finally,the two-stage SCR urea injection control strategy was certified under the world harmonized transient cycle(WHTC).The results demonstrate that the composite value of engine outlet NO_(x) emissions under cold and hot start WHTC cycles is 13 g/(kW·h).Meanwhile,the composite value of tailpipe NO_(x) emissions under cold and hot start WHTC cycles is 0.065 g/(kW·h),representing only 14%of the EU VI limit value of 0.46 g/(kW·h).Thus,the findings demonstrate that integrating an accurate NH_(3) storage prediction method with the two-stage SCR co-control function is crucial for heavy-duty diesel engines to achieve ultra-low NO_(x) emissions.展开更多
Lycium ruthenicum(black goji)is a medicinal plant native to the Qinghai-Tibet Plateau(Cao et al.,2021),known for its high anthocyanin content(Avula et al.,2023)in fruit.In contrast,the white and purple variants contai...Lycium ruthenicum(black goji)is a medicinal plant native to the Qinghai-Tibet Plateau(Cao et al.,2021),known for its high anthocyanin content(Avula et al.,2023)in fruit.In contrast,the white and purple variants contain little anthocyanin(Zong et al.,2019).The evolutionary relationship of the variants and the genetic basis underlying their color differentiation has rarely been well studied at the whole genome level(Li et al.,2024).In this study,we present a near-complete genome assembly of L.ruthenicum,providing a valuable resource for investigating its evolutionary relationships with other Lycium species and fruit color variants.Through integrated genomic,transcriptomic,and functional analyses,we identify a key structural variation of AN1,a bHLH transcription factor essential for anthocyanin biosynthesis,which underlies the formation of white and purple goji in L.ruthenicum.展开更多
Gastrointestinal hemangioma(GIH)is clinically rare,accounting for 7%-10%of benign gastrointestinal tumors and 0.5%of systemic hemangiomas.GIH can occur as either solitary or multiple lesions,with gastrointestinal blee...Gastrointestinal hemangioma(GIH)is clinically rare,accounting for 7%-10%of benign gastrointestinal tumors and 0.5%of systemic hemangiomas.GIH can occur as either solitary or multiple lesions,with gastrointestinal bleeding as a significant clinical manifestation.Understanding the clinical and endoscopic features of GIH is essential for improving diagnostic accuracy,particularly through endoscopy and selective arteriography,which are highly effective in diagnosing GIH and preventing misdiagnosis and inappropriate treatment.Upon confirmed diagnosis,it is essential to thoroughly evaluate the patient's condition to determine the most suitable treatment modality—whether surgical,endoscopic,or minimally invasive intervention.The minimally invasive interventional partial embolization therapy using polyvinyl alcohol particles,proposed and implemented by Pospisilova et al,has achieved excellent clinical outcomes.This approach reduces surgical trauma and the inherent risks of traditional surgical treatments.展开更多
In the western segment of the East Kunlun Orogen(WEKO),muscovite granite and garnet granite from the Hureguole intrusion exhibit zircon U-Pb ages of 435-442 Ma.Geochemically,these rocks contain high concentrations of ...In the western segment of the East Kunlun Orogen(WEKO),muscovite granite and garnet granite from the Hureguole intrusion exhibit zircon U-Pb ages of 435-442 Ma.Geochemically,these rocks contain high concentrations of SiO_(2),K_(2)O and Al_(2)O_(3),with low concentrations of TiO_(2)and MgO,indicating a peraluminous high-K calc-alkaline affinity.They are enriched in Rb,Th,U and LREE,depleted in Eu,Ba,Sr and Ti,being classified as S-type granites.Negative whole-rockε_(Nd)(t)values(-9.8 to-9.1)and zirconε_(Hf)(t)values(-11.6 to-8.2)for those granites indicate that they were derived from partial melting of pelitic rocks in the Paleoproterozoic Baishahe Formation of the Jinshuikou Group.Based on the collected zircon ages,Cambrian-Devonian magmatic activity in the WEKO was divided into three stages:early(446-520 Ma),middle(427-441 Ma)and late(372-424 Ma)stages.Statistically,whole-rock Nd and zircon Hf isotope data(ε_(Nd)(t)/T_(DM)^(Nd),ε_(Hf)(t)/T_(DMC)^(Hf))from Paleozoic igneous rocks in the WEKO reveal a magma source that was initially dominated by depleted mantle components in the northward subduction stage of the Proto-Tethy an Ocean plate(446-520 Ma),shifting to predominantly crustal sources during the closure period of the North Qimantagh back-arc basin(427-441 Ma),then to crust-mantle mixed sources in the post-collision stage(372-424 Ma).展开更多
Boron adsorbents with high adsorption capacities have long been a focus of research for a long time.This study used small molecular polyols with different hydroxyl groups as functional monomers and as end-capping agen...Boron adsorbents with high adsorption capacities have long been a focus of research for a long time.This study used small molecular polyols with different hydroxyl groups as functional monomers and as end-capping agents,functional dendritic polyurethanes with nano structure were successfully prepared by one-pot method.The single molecule size and surface morphology were characterized by dynamic light scattering,transmission electron microscopy and scanning electron microscopy,and the molecular size in the dry state was 11 to 18 nm.The prepared materials were used as the boron adsorbents,and the effects of pH,time,boron solution concentration and temperature on the adsorption were studied.The results showed that the capacity of adsorbed boron could reach 110-130 mg·g^(-1).Adsorption was a homogeneous monolayer adsorption controlled by chemisorption,and adsorption thermodynamics showed that was a spontaneous endothermic process.Adsorption behavior was best described by the pseudo-second-order kinetic model and the Langmuir isotherm.This study also showed that it was difficult for ortho/meta-hydroxyl groups to chelate with H_(3)BO_(3) and other polyborates,and the chelates mainly had good chelating properties with B(OH)_(4)^(-),and the chelates formed had large steric hindrance.At the same time,increasing the number of hydroxyl groups of functional monomers was beneficial to increase the adsorption capacity of materials.In addition,the cyclic adsorption/desorption experiments showed that DPUs have good cyclic stability.At the same time,the adsorption results of the original salt lake brine showed that other metal ions in the brine had little effect on the adsorption of boron,and the adsorption capacity was as high as52.93 mg·g^(-1),and the maximum adsorption capacity was obtained by Adams-Bohart model to58.80 mg·g^(-1).The outstanding selectivity and adsorption capacity of these materials have broad potential application,and are expected to be used for the efficient adsorption and removal in boroncontaining water bodies.展开更多
BACKGROUND Acute drug-induced liver injury(DILI)events caused by chronic liver disease are relatively common.Some researchers believe that nonalcoholic fatty liver(NAFL)increases the overall risk of DILI.The clinical ...BACKGROUND Acute drug-induced liver injury(DILI)events caused by chronic liver disease are relatively common.Some researchers believe that nonalcoholic fatty liver(NAFL)increases the overall risk of DILI.The clinical characteristics and prognosis of DILI in the context of NAFL disease(NAFLD)are still unclear.Therefore,hospitalized patients with NAFLD combined with DILI at the Tianjin Second People's Hospital were included in this study.The clinical manifestations,classifications,severities,laboratory indicators,and clinical outcomes of the enrolled patients were analyzed,and the clinical characteristics and prognoses of the NAFL+DILI patients were evaluated.AIM To investigate the clinical characteristics and prognosis of DILI in the context of NAFL.METHODS Eighty-nine patients diagnosed with DILI and 110 patients diagnosed with both DILI and NAFL at the Tianjin Second People's Hospital were enrolled.Clinical data,including demographic characteristics,clinical features,laboratory test results,pathology findings,autoantibody titers,suspected drugs,and outcomes,were collected from the two groups of patients.All enrolled patients were followed up to determine the liver function recovery time.RESULTS Compared with the patients in the DILI group,those in the NAFL+DILI group had higher body mass indices;Controlled Attenuation Parameter scores;and triglyceride,total cholesterol,low-density lipoprotein,and insulin levels.The levels of the cytokines interleukin-4 and complement complement c3(C3)were also greater in the NAFL+DILI group than in the DILI group.The proportions of patients with cholestatic-type DILI(16.4%vs 4.5%),cholestasis seen on pathoscopy(40.9%vs 25.8%),grade 2 or above DILI(48.18%vs 40.45%),and a recovery time for liver function ranging from 90 to 180 days(30.6%vs 15.5%)were greater in the NAFL+DILI group than in the DILI group.All of the abovementioned differences between the groups were statistically significant(P<0.05).The autoantibody positivity rates did not significantly differ between the two groups(P>0.05),and the proportions of patients who progressed to chronic drug hepatitis or autoimmune hepatitis were not significantly different between the two groups(both P>0.05).CONCLUSION In the context of NAFL,DILI is more likely to be cholestatic,with a greater degree of liver injury,a longer recovery time,and more pronounced expression of immune factors.展开更多
High-resolution,continuous Late Holocene lacustrine records are scarce in the Qaidam Basin,but is of especially important for our understanding the future climate variability in the western China.Here,we use grain siz...High-resolution,continuous Late Holocene lacustrine records are scarce in the Qaidam Basin,but is of especially important for our understanding the future climate variability in the western China.Here,we use grain size,element content and XRD-identified data from the Lake Hurleg in the eastern Qaidam Basin to present the Late Holocene climate variability,which have been temporally constrained using 210Pb-,137Cs-and AMS 14C dating.Our records demonstrate that decreased precipitation climate occurred at~800–1000 yr and~1300–1800 yr intervals,and increased precipitation occurred at~354–800 yr,~1000–1300 yr and~1800 yr to the present.The results show that the Qaidam Basin has undergone a process of warming and humidification since the Industrial Revolution,which is consistent with the meteorological records.The climate in the northeastern Qaidam Basin is dominated by the Asian Monsoon.展开更多
0 INTRODUCTION The Haidewula uranium deposit is located in the Haidewula volcanic basin,which hosts a suite of basic,intermediate to felsic volcanic and subvolcanic rocks,including basalt,trachyte,trachyandesite.Previ...0 INTRODUCTION The Haidewula uranium deposit is located in the Haidewula volcanic basin,which hosts a suite of basic,intermediate to felsic volcanic and subvolcanic rocks,including basalt,trachyte,trachyandesite.Previous geochronological studies of the intrusions within this volcanic basin suggest that they primarily formed during the Silurian and Triassic periods(Dai et al.,2025;Sun et al.,2024;Wang et al.,2024;Zhu et al.,2022;Lei et al.,2021).展开更多
Global warming and human activities have reduced the concentrations of dissolved oxygen in the bottom water of lakes,resulting in increased anoxia in surface sediments.This increased anoxia likely alters carbon cyclin...Global warming and human activities have reduced the concentrations of dissolved oxygen in the bottom water of lakes,resulting in increased anoxia in surface sediments.This increased anoxia likely alters carbon cycling processes(e.g.,organic carbon mineralization)by altering microbial community composition and functions in lakes.However,it remains unclear how organic carbon mineralization responds to increased anoxia in surface sediments of lakes(particularly saline lakes).In this study,CO_(2)production in surface sediments of six lakes with different salinity(0.47-250 g/L)on the Tibetan Plateau was investigated using microcosm incubations under aerobic and anaerobic conditions,respectively,followed by geochemical and microbial analyses.The results showed that for the freshwater lake,CO_(2)production rates in anaerobic sediment microcosms were significantly(P<0.05)lower than their aerobic counterparts.In contrast,an opposite trend was observed for CO_(2)production in saline lakes.Furthermore,the CO_(2)production rates decreased significantly(P<0.05)under aerobic conditions,while it exhibited a hump-like relationship with increasing salinity under anaerobic conditions.Taken together,our results suggest that increased anoxia would enhance organic carbon mineralization in surface sediments of saline lakes and help understand carbon feedback on global changes in saline lakes.展开更多
Exploring the specific environmental impacts and mechanisms of China’s sustainable development pilot policy can enrich and expand China’s institutional and practical experiences,offering valuable insights and refere...Exploring the specific environmental impacts and mechanisms of China’s sustainable development pilot policy can enrich and expand China’s institutional and practical experiences,offering valuable insights and references for advancing global environmental sustainability.This study selects the National Innovation Demonstration Zone for Sustainable Development Agenda(NIDZSDA)as the sample and empirically evaluates the effects of the policy on urban environmental quality,using panel data from 74 prefecture-level cities in China between 2006 and 2020.The findings indicate that the sustainable development policy significantly improves urban environmental quality.Two key mechanisms identified are the aggregation of high-quality talent and the enhancement of technological innovation capabilities.Furthermore,the policy exhibits heterogeneous effects across different types of cities,with more pronounced improvements observed in mega and super cities,as well as in resource-based cities.展开更多
Introduction Tibetan sheep,economically important animals on the Qinghai–Tibet Plateau,have diversified into numerous local breeds with unique characteristics through prolonged environmental adaptation and selective ...Introduction Tibetan sheep,economically important animals on the Qinghai–Tibet Plateau,have diversified into numerous local breeds with unique characteristics through prolonged environmental adaptation and selective breeding.However,most current research focuses on one or two breeds,and lacks a comprehensive representa-tion of the genetic diversity across multiple Tibetan sheep breeds.This study aims to fill this gap by investigating the genetic structure,diversity and high-altitude adaptation of 6 Tibetan sheep breeds using whole-genome rese-quencing data.Results Six Tibetan sheep breeds were investigated in this study,and whole-genome resequencing data were used to investigate their genetic structure and population diversity.The results showed that the 6 Tibetan sheep breeds exhibited distinct separation in the phylogenetic tree;however,the levels of differentiation among the breeds were minimal,with extensive gene flow observed.Population structure analysis broadly categorized the 6 breeds into 3 distinct ecological types:plateau-type,valley-type and Euler-type.Analysis of unique single-nucleotide polymor-phisms(SNPs)and selective sweeps between Argali and Tibetan sheep revealed that Tibetan sheep domestication was associated primarily with sensory and signal transduction,nutrient absorption and metabolism,and growth and reproductive characteristics.Finally,comprehensive analysis of selective sweep and transcriptome data sug-gested that Tibetan sheep breeds inhabiting different altitudes on the Qinghai–Tibet Plateau adapt by enhancing cardiopulmonary function,regulating body fluid balance through renal reabsorption,and modifying nutrient diges-tion and absorption pathways.Conclusion In this study,we investigated the genetic diversity and population structure of 6 Tibetan sheep breeds in Qinghai Province,China.Additionally,we analyzed the domestication traits and investigated the unique adapta-tion mechanisms residing varying altitudes in the plateau region of Tibetan sheep.This study provides valuable insights into the evolutionary processes of Tibetan sheep in extreme environments.These findings will also contribute to the preservation of genetic diversity and offer a foundation for Tibetan sheep diversity preservation and plateau animal environmental adaptation mechanisms.展开更多
基金partially supported by the National Natural Science Foundation of China(No.51901153)Shanxi Scholarship Council of China(No.2019032)+1 种基金the Natural Science Foundation of Shanxi,China(No.202103021224049)the Shanxi Zhejiang University New Materials and Chemical Research Institute Scientific Research Project,China(No.2022SX-TD025)。
文摘A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anode dissolution kinetics.A Mg-air battery prepared using this anode exhibits a cell voltage of 1.626 V at 0.5 mA/cm^(2),reasonable anodic efficiency of 58.17%,and good specific energy of 1730.96 mW·h/g at 10 mA/cm^(2).This performance is attributed to the effective reactive anode surface,the suppressed chunk effect,and weak self-corrosion owing to the homogeneous basal texture.
基金the National Natural Science:Foundation of China(52375370)the Open Project of Salt Lake Chemical Engineering Research Complex,Qinghai University(2023-DXSSKF-Z02)+2 种基金the Nat-ural Science Foundation of Shanxi(202103021224049)GDAS Projects of International cooperation platform of Sci-ence and Technology(2022GDASZH-2022010203-003)Guangdong province Science and Technology Plan Projects(2023B1212060045).
文摘The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment.
基金supported by National Natural Science Foundation of China(82104082)Natural Science Foundation of Qinghai Province(2024-ZJ-911).
文摘The recent commercialization of gene products has sparked significant interest in gene therapy,necessitating efficient and precise gene delivery via various vectors.Currently,viral vectors and lipid-based nanocarriers are the predominant choices and have been extensively investigated and reviewed.Beyond these vectors,polymeric nanocarriers also hold the promise in therapeutic gene delivery owing to their versatile functionalities,such as improving the stability,cellar uptake and endosomal escape of nucleic acid drugs,along with precise delivery to targeted tissues.This review presents a brief overview of the status quo of the emerging polymeric nanocarriers for therapeutic gene delivery,focusing on key cationic polymers,nanocarrier types,and preparation methods.It also highlights targeted diseases,strategies to improve delivery efficiency,and potential future directions in this research area.The review is hoped to inspire the development,optimization,and clinical translation of highly efficient polymeric nanocarriers for therapeutic gene delivery.
基金supported by the National High Level Hospital Clinical Research Funding (2022-PUMCH-B-109)Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFMS)(2021-I2M-1-020)。
文摘BACKGROUND: Sepsis, a common acute and critical disease, leads to 11 million deaths annually worldwide. Probiotics are living microorganisms that are beneficial to the host and may benefit sepsis outcomes, but their effects are stil inconclusive. This study aimed to evaluate the overal eff ect of probiotics on the prognosis of patients with sepsis.DATA RESOURCES: We searched several sources for published/presented studies, including Pub Med, EMBASE, Web of Science, the Cochrane Library and the US National Library of Medicine Clinical Trials Register(www.clinicaltrials.gov) updated through July 30, 2023, to identify all relevant randomized controlled trials(RCTs) or observational studies that assessed the effectiveness of probiotics or synbiotics in patients with sepsis and reported mortality. We focused primarily on mortality during the study period and analyzed secondary outcomes, including 28-day mortality, in-intensive care unit(ICU) mortality and other outcomes.RESULTS: Data from 405 patients in five RCTs and 108 patients in one cohort study were included in the analysis. The overall quality of the studies was satisfactory, but clinical heterogeneity existed. All adult studies reported a tendency for probiotics to reduce the mortality of patients with sepsis, and most studies reported a decreasing trend in the incidence of infectious complications, length of ICU stay and duration of antibiotic use. There was only one RCT involving children.CONCLUSION: Probiotics show promise for improving the prognosis of patients with sepsis, including reducing mortality and the incidence of infectious complications, particularly in adult patients. Despite the limited number of studies, especially in children, these findings will be encouraging for clinical practice in the treatment of sepsis and suggest that gut microbiota-targeted therapy may improve the prognosis of patients with sepsis.
基金supported by the National Natural Science Foundation of China(Grant number:41440027)Geological Prospecting Fund of Qinghai Province(Grant number:2017042185sh029)Special project of Key Laboratory of Environmental Geology of Qinghai Province(Grant number:2023-KJ-13).Our special appreciate go to the editors and anonymous reviewers for their critical reviews and helpful comments.
文摘The sources and accumulation of heavy metals in soil are of great significance for soil utilization and pollution control.Lead(Pb),a common heavy metal element,tends to accumulate in the soils with time.Excess Pb in soils accumulates in plants and becomes toxic to humans and livestock when it enters the food chain.The historical data of Pb contents in soils in northwest China were stud-ied to establish the historical change curve in this paper.The results indicate geochemical background and wind and dust deposition have the minor contribution to the accumulation of Pb in soils,but human activities have caused a rapid accumulation of Pb in soils.From 1990 to 2020,the accumulation of about 0.1 mg/kg of Pb in the soils is due to natural wind-dust deposits,but the content of Pb in the soils has nearly tripled from about 22 mg/kg to about 52 mg/kg with the process of anthropogenic urbanization and industrialization.We found that the influence of human activities on lead content was closely related to the total primary energy production(10,000 tons of SCE),and the evolution of soil Pb contents in the study area was consis-tent with the Allometric1 model.
基金supported by the Natural Science Foundation of Qinghai Province in China(No.2019-ZJ-944Q)the University-level Planning Project of Qinghai Minzu University of Qinghai Province in China(Nos.2022GH11 and 2022GH13)。
文摘Up to now,“Turn-on”fluorescence sensor exhibits promising potential toward the detection of heavy metal ions,anions,drugs,organic dyes,DNA,pesticides,and other amino acids due to their simple,quick detection,and high sensitivity and selectivity.Herein,a novel fluorescence method of detecting Cr^(3+)in an aqueous solution was described based on the fluorescence resonance energy transfer between rhodamine B(Rh B)and gold nanoparticles(Au NPs).The fluorescence of Rh B solution could be obviously quenched(“off”state)with the presence of citrate-stabilized Au NPs.However,upon addition of Cr^(3+)to Au NPs@Rh B system,the fluorescence of Au NPs was recovered owing to the strong interaction between Cr^(3+)and the specific groups on the surface of citrate-stabilized Au NPs,which will lead to the aggregation of Au NPs(“on”state).At this point,the color of the reaction solution turned to black.Under optimal conditions,the limit of detection(LOD)for Cr^(3+)was 0.95 n M(signal-to-noise ratio,S/N=3)with a linear range of 0.164 n M to 3.270μM.Furthermore,the proposed method exhibits excellent performances,such as rapid analysis,high sensitivity,extraordinary selectivity,easy preparation,switch-on fluorescence response,and non-time consuming.
文摘BACKGROUND At present,prophylactic ileostomy is commonly used to protect distal intestinal anastomoses,particularly during the recovery period following colorectal surgery.However,after the ileum is returned to the abdominal cavity,abdominal closure using traditional vertical interrupted suturing is associated with a higher incidence of wound infections.For patients undergoing ileostomy closure,selecting an appropriate suturing method for the skin incision at the stoma site is crucial for improving patient prognosis.AIM To investigate the impact of three different skin suturing methods at the ileostomy closure site on patient prognosis.METHODS Thirty patients who underwent ileostomy closure at the Affiliated Hospital of Qinghai University between January 2024 and October 2024 were selected based on inclusion and exclusion criteria.The patients were divided into three groups:The purse-string suture group,the cross-suture group,and the vertical interrupted suture group,with 10 cases in each group.The purse-string suture group,cross-suture group,and vertical interrupted suture group used purse-string,cross,and vertical interrupted suturing methods,respectively,for the skin incision at the ileostomy closure site.RESULTS There were no statistically significant differences among the three groups in terms of operative time,intraoperative blood loss,time to resume liquid diet,time to first bowel movement,postoperative hospital stay,hospitalization costs,or levels of white blood cell count,hemoglobin,and albumin on the third postoperative day(P>0.05).Nevertheless,significant differences(P<0.05)were observed in incision suture removal time,wound healing time,C-reactive protein levels on the third postoperative day,visual analog scale pain scores during the first three postoperative days,and the incidence of surgical site infection.Overall,the therapeutic outcomes of the pursestring suture group and the cross-suture group were superior to the vertical interrupted suture group.CONCLUSION Using purse-string or cross-suturing methods for skin incision at the ileostomy closure site can shorten wound healing and suture removal times,reduce surgical site infection incidence and postoperative inflammatory response,alleviate incision pain,and promote rapid postoperative recovery.
文摘We editorialized on this study published by Zou et al.Gastrointestinal bleeding is a common clinical symptom,and hemocoagulase is frequently used to treat hemorrhagic conditions.However,studies have shown that hemocoagulase treatment may induce acquired hypofibrinogenemia,further aggravating the bleeding.Zou et al retrospectively analyzed 109 gastrointestinal bleeding cases to explore the hazards underlying hypofibrinogenemia induced by hemocoagulase,and identified higher total dose of hemocoagulase and female sex,as well as low baseline fibrinogen levels as significant hazards.Consequently,clinicians should be aware of both intrinsic and extrinsic risk factors when using hemocoagulase among this patient population,and remain vigilant for the potential development of hemocoagulase-induced hypofibrinogenemia.
基金Project supported by the National Natural Science Foundation of China(Grant No.12261072)。
文摘The widespread popularization and application of laser technology have provided a powerful tool for a deeper understanding of the material world and given birth to several emerging research fields.This study mainly focuses on the following three key aspects.First,the classical ensemble method is adopted to conduct a comprehensive and in-depth analysis of two-dimensional(2D)matter–wave pulses in Bose–Fermi mixed gases(including linear and nonlinear pulses).Second,under the strict constraints of unitary systems,a coupled Kd V equation is successfully derived,and the prolongation structure theory is skillfully used to carry out detailed calculations and analyses on this equation.Thus,the prolongation algebra of this equation is accurately determined,and the corresponding Lax pair is rigorously derived.Finally,based on the carefully obtained Lax pair from the prolongation structure theory,the soliton solutions of this equation are further analyzed in depth,and intuitive images of each soliton solution are carefully drawn.This lays a solid foundation for subsequent detailed research on these soliton characteristics and provides great convenience.
基金supported by the National Natural Science Foundation of China(No.51921004).
文摘The emission regulations for heavy-duty diesel engines regarding nitrogen oxide(NO_(x))are becoming increasingly stringent,particularly in relation to cold start cycles.While the twostage selective catalytic reduction(SCR)has the potential to achieve ultra-low NO_(x) emissions,several challenges remain,including the accurate prediction of ammonia(NH_(3))storage mass and the co-control of the two-stage SCR.The first step in this study involved the establishment of a rapid control prototype platform to facilitate the development and validation of a two-stage SCR control strategy.Secondly,an initial method for predicting the NH_(3) storage based on the mass conservation law was proposed,which was subsequently improved by filling and emptying experiments.The third step involved the development of a two-stage SCR co-control strategy,including obtaining the steady-state NH_(3) storage target value,dynamic correction for NH_(3) storage target value,regulation of NH_(3) storage,and control of the close-coupled SCR urea injector state.Finally,the two-stage SCR urea injection control strategy was certified under the world harmonized transient cycle(WHTC).The results demonstrate that the composite value of engine outlet NO_(x) emissions under cold and hot start WHTC cycles is 13 g/(kW·h).Meanwhile,the composite value of tailpipe NO_(x) emissions under cold and hot start WHTC cycles is 0.065 g/(kW·h),representing only 14%of the EU VI limit value of 0.46 g/(kW·h).Thus,the findings demonstrate that integrating an accurate NH_(3) storage prediction method with the two-stage SCR co-control function is crucial for heavy-duty diesel engines to achieve ultra-low NO_(x) emissions.
基金supported by the Qinghai Provincial Key Laboratory of Crop Molecular Breeding[2023-1-1].
文摘Lycium ruthenicum(black goji)is a medicinal plant native to the Qinghai-Tibet Plateau(Cao et al.,2021),known for its high anthocyanin content(Avula et al.,2023)in fruit.In contrast,the white and purple variants contain little anthocyanin(Zong et al.,2019).The evolutionary relationship of the variants and the genetic basis underlying their color differentiation has rarely been well studied at the whole genome level(Li et al.,2024).In this study,we present a near-complete genome assembly of L.ruthenicum,providing a valuable resource for investigating its evolutionary relationships with other Lycium species and fruit color variants.Through integrated genomic,transcriptomic,and functional analyses,we identify a key structural variation of AN1,a bHLH transcription factor essential for anthocyanin biosynthesis,which underlies the formation of white and purple goji in L.ruthenicum.
基金Supported by Science and Technology Plan of Qinghai Province,No.2023-ZJ-787.
文摘Gastrointestinal hemangioma(GIH)is clinically rare,accounting for 7%-10%of benign gastrointestinal tumors and 0.5%of systemic hemangiomas.GIH can occur as either solitary or multiple lesions,with gastrointestinal bleeding as a significant clinical manifestation.Understanding the clinical and endoscopic features of GIH is essential for improving diagnostic accuracy,particularly through endoscopy and selective arteriography,which are highly effective in diagnosing GIH and preventing misdiagnosis and inappropriate treatment.Upon confirmed diagnosis,it is essential to thoroughly evaluate the patient's condition to determine the most suitable treatment modality—whether surgical,endoscopic,or minimally invasive intervention.The minimally invasive interventional partial embolization therapy using polyvinyl alcohol particles,proposed and implemented by Pospisilova et al,has achieved excellent clinical outcomes.This approach reduces surgical trauma and the inherent risks of traditional surgical treatments.
基金funded by the China Postdoctoral Science Foundation(Grant No.2019M663959XB)the Geological Survey and Development Bureau of Qinghai Province 2019 Geological Survey Project(2019[45])the Key Laboratory of Deep Dynamics of the Ministry of Natural Resources,Open Research Project 2019。
文摘In the western segment of the East Kunlun Orogen(WEKO),muscovite granite and garnet granite from the Hureguole intrusion exhibit zircon U-Pb ages of 435-442 Ma.Geochemically,these rocks contain high concentrations of SiO_(2),K_(2)O and Al_(2)O_(3),with low concentrations of TiO_(2)and MgO,indicating a peraluminous high-K calc-alkaline affinity.They are enriched in Rb,Th,U and LREE,depleted in Eu,Ba,Sr and Ti,being classified as S-type granites.Negative whole-rockε_(Nd)(t)values(-9.8 to-9.1)and zirconε_(Hf)(t)values(-11.6 to-8.2)for those granites indicate that they were derived from partial melting of pelitic rocks in the Paleoproterozoic Baishahe Formation of the Jinshuikou Group.Based on the collected zircon ages,Cambrian-Devonian magmatic activity in the WEKO was divided into three stages:early(446-520 Ma),middle(427-441 Ma)and late(372-424 Ma)stages.Statistically,whole-rock Nd and zircon Hf isotope data(ε_(Nd)(t)/T_(DM)^(Nd),ε_(Hf)(t)/T_(DMC)^(Hf))from Paleozoic igneous rocks in the WEKO reveal a magma source that was initially dominated by depleted mantle components in the northward subduction stage of the Proto-Tethy an Ocean plate(446-520 Ma),shifting to predominantly crustal sources during the closure period of the North Qimantagh back-arc basin(427-441 Ma),then to crust-mantle mixed sources in the post-collision stage(372-424 Ma).
基金financially supported by Applied Basic Research Project of Qinghai province(2023-ZJ-774)。
文摘Boron adsorbents with high adsorption capacities have long been a focus of research for a long time.This study used small molecular polyols with different hydroxyl groups as functional monomers and as end-capping agents,functional dendritic polyurethanes with nano structure were successfully prepared by one-pot method.The single molecule size and surface morphology were characterized by dynamic light scattering,transmission electron microscopy and scanning electron microscopy,and the molecular size in the dry state was 11 to 18 nm.The prepared materials were used as the boron adsorbents,and the effects of pH,time,boron solution concentration and temperature on the adsorption were studied.The results showed that the capacity of adsorbed boron could reach 110-130 mg·g^(-1).Adsorption was a homogeneous monolayer adsorption controlled by chemisorption,and adsorption thermodynamics showed that was a spontaneous endothermic process.Adsorption behavior was best described by the pseudo-second-order kinetic model and the Langmuir isotherm.This study also showed that it was difficult for ortho/meta-hydroxyl groups to chelate with H_(3)BO_(3) and other polyborates,and the chelates mainly had good chelating properties with B(OH)_(4)^(-),and the chelates formed had large steric hindrance.At the same time,increasing the number of hydroxyl groups of functional monomers was beneficial to increase the adsorption capacity of materials.In addition,the cyclic adsorption/desorption experiments showed that DPUs have good cyclic stability.At the same time,the adsorption results of the original salt lake brine showed that other metal ions in the brine had little effect on the adsorption of boron,and the adsorption capacity was as high as52.93 mg·g^(-1),and the maximum adsorption capacity was obtained by Adams-Bohart model to58.80 mg·g^(-1).The outstanding selectivity and adsorption capacity of these materials have broad potential application,and are expected to be used for the efficient adsorption and removal in boroncontaining water bodies.
文摘BACKGROUND Acute drug-induced liver injury(DILI)events caused by chronic liver disease are relatively common.Some researchers believe that nonalcoholic fatty liver(NAFL)increases the overall risk of DILI.The clinical characteristics and prognosis of DILI in the context of NAFL disease(NAFLD)are still unclear.Therefore,hospitalized patients with NAFLD combined with DILI at the Tianjin Second People's Hospital were included in this study.The clinical manifestations,classifications,severities,laboratory indicators,and clinical outcomes of the enrolled patients were analyzed,and the clinical characteristics and prognoses of the NAFL+DILI patients were evaluated.AIM To investigate the clinical characteristics and prognosis of DILI in the context of NAFL.METHODS Eighty-nine patients diagnosed with DILI and 110 patients diagnosed with both DILI and NAFL at the Tianjin Second People's Hospital were enrolled.Clinical data,including demographic characteristics,clinical features,laboratory test results,pathology findings,autoantibody titers,suspected drugs,and outcomes,were collected from the two groups of patients.All enrolled patients were followed up to determine the liver function recovery time.RESULTS Compared with the patients in the DILI group,those in the NAFL+DILI group had higher body mass indices;Controlled Attenuation Parameter scores;and triglyceride,total cholesterol,low-density lipoprotein,and insulin levels.The levels of the cytokines interleukin-4 and complement complement c3(C3)were also greater in the NAFL+DILI group than in the DILI group.The proportions of patients with cholestatic-type DILI(16.4%vs 4.5%),cholestasis seen on pathoscopy(40.9%vs 25.8%),grade 2 or above DILI(48.18%vs 40.45%),and a recovery time for liver function ranging from 90 to 180 days(30.6%vs 15.5%)were greater in the NAFL+DILI group than in the DILI group.All of the abovementioned differences between the groups were statistically significant(P<0.05).The autoantibody positivity rates did not significantly differ between the two groups(P>0.05),and the proportions of patients who progressed to chronic drug hepatitis or autoimmune hepatitis were not significantly different between the two groups(both P>0.05).CONCLUSION In the context of NAFL,DILI is more likely to be cholestatic,with a greater degree of liver injury,a longer recovery time,and more pronounced expression of immune factors.
基金supported by the National Natural Science Foundation of China(No.41401059)Science and Technology Plan Project of Qinghai Province(2022-ZJ-732)West Light Foundation of Chinese Academy of Sciences(No.Y510091019)。
文摘High-resolution,continuous Late Holocene lacustrine records are scarce in the Qaidam Basin,but is of especially important for our understanding the future climate variability in the western China.Here,we use grain size,element content and XRD-identified data from the Lake Hurleg in the eastern Qaidam Basin to present the Late Holocene climate variability,which have been temporally constrained using 210Pb-,137Cs-and AMS 14C dating.Our records demonstrate that decreased precipitation climate occurred at~800–1000 yr and~1300–1800 yr intervals,and increased precipitation occurred at~354–800 yr,~1000–1300 yr and~1800 yr to the present.The results show that the Qaidam Basin has undergone a process of warming and humidification since the Industrial Revolution,which is consistent with the meteorological records.The climate in the northeastern Qaidam Basin is dominated by the Asian Monsoon.
基金financially supported by projects from the National Natural Science Foundation of China(No.42321001)the Qinghai Provincial Department of Science and Technology Key R&D Project(No.2025-SF-141)+1 种基金the Qinghai“Kunlun Talent”Program(Qing RC Talent Zi(2024)No.1)the Academician Zhao Pengda Innovation Center in Qinghai Geological Bureau of Nuclear Industry。
文摘0 INTRODUCTION The Haidewula uranium deposit is located in the Haidewula volcanic basin,which hosts a suite of basic,intermediate to felsic volcanic and subvolcanic rocks,including basalt,trachyte,trachyandesite.Previous geochronological studies of the intrusions within this volcanic basin suggest that they primarily formed during the Silurian and Triassic periods(Dai et al.,2025;Sun et al.,2024;Wang et al.,2024;Zhu et al.,2022;Lei et al.,2021).
基金supported by grants from the National Natural Science Foundation of China(Nos.42272356,92251304)the Kunlun Talented People of Qinghai Province,High-End Innovation and Entrepreneurship talents(Grant to Jiang Hongchen)+4 种基金the Qinghai Provincial Key Laboratory of Geology and Environment of Salt Lakes(the Science and Technology Plan Project of Qinghai Province Incentive Fund,No.2024-KFKTA08)the 111 Program(the State Administration of Foreign Experts Affairs&the Ministry of Education of China,No.B18049)the Second Tibetan Plateau Scientific Expedition and Research Program(Polymenakou et al.)(No.2019QZKK0805)the Science and Technology Plan Project of Qinghai Province(No.2022-ZJ-Y08)Fundamental Research Funds for the Central Universities,China University of Geosciences(Wuhan)。
文摘Global warming and human activities have reduced the concentrations of dissolved oxygen in the bottom water of lakes,resulting in increased anoxia in surface sediments.This increased anoxia likely alters carbon cycling processes(e.g.,organic carbon mineralization)by altering microbial community composition and functions in lakes.However,it remains unclear how organic carbon mineralization responds to increased anoxia in surface sediments of lakes(particularly saline lakes).In this study,CO_(2)production in surface sediments of six lakes with different salinity(0.47-250 g/L)on the Tibetan Plateau was investigated using microcosm incubations under aerobic and anaerobic conditions,respectively,followed by geochemical and microbial analyses.The results showed that for the freshwater lake,CO_(2)production rates in anaerobic sediment microcosms were significantly(P<0.05)lower than their aerobic counterparts.In contrast,an opposite trend was observed for CO_(2)production in saline lakes.Furthermore,the CO_(2)production rates decreased significantly(P<0.05)under aerobic conditions,while it exhibited a hump-like relationship with increasing salinity under anaerobic conditions.Taken together,our results suggest that increased anoxia would enhance organic carbon mineralization in surface sediments of saline lakes and help understand carbon feedback on global changes in saline lakes.
基金fund support was received from National Social Science Fund of China[Grant No.23BJL010].
文摘Exploring the specific environmental impacts and mechanisms of China’s sustainable development pilot policy can enrich and expand China’s institutional and practical experiences,offering valuable insights and references for advancing global environmental sustainability.This study selects the National Innovation Demonstration Zone for Sustainable Development Agenda(NIDZSDA)as the sample and empirically evaluates the effects of the policy on urban environmental quality,using panel data from 74 prefecture-level cities in China between 2006 and 2020.The findings indicate that the sustainable development policy significantly improves urban environmental quality.Two key mechanisms identified are the aggregation of high-quality talent and the enhancement of technological innovation capabilities.Furthermore,the policy exhibits heterogeneous effects across different types of cities,with more pronounced improvements observed in mega and super cities,as well as in resource-based cities.
基金supported by the Natural Science Foundation of Qinghai Province(No.2022-ZJ-901)the National Breeding Joint Research Project。
文摘Introduction Tibetan sheep,economically important animals on the Qinghai–Tibet Plateau,have diversified into numerous local breeds with unique characteristics through prolonged environmental adaptation and selective breeding.However,most current research focuses on one or two breeds,and lacks a comprehensive representa-tion of the genetic diversity across multiple Tibetan sheep breeds.This study aims to fill this gap by investigating the genetic structure,diversity and high-altitude adaptation of 6 Tibetan sheep breeds using whole-genome rese-quencing data.Results Six Tibetan sheep breeds were investigated in this study,and whole-genome resequencing data were used to investigate their genetic structure and population diversity.The results showed that the 6 Tibetan sheep breeds exhibited distinct separation in the phylogenetic tree;however,the levels of differentiation among the breeds were minimal,with extensive gene flow observed.Population structure analysis broadly categorized the 6 breeds into 3 distinct ecological types:plateau-type,valley-type and Euler-type.Analysis of unique single-nucleotide polymor-phisms(SNPs)and selective sweeps between Argali and Tibetan sheep revealed that Tibetan sheep domestication was associated primarily with sensory and signal transduction,nutrient absorption and metabolism,and growth and reproductive characteristics.Finally,comprehensive analysis of selective sweep and transcriptome data sug-gested that Tibetan sheep breeds inhabiting different altitudes on the Qinghai–Tibet Plateau adapt by enhancing cardiopulmonary function,regulating body fluid balance through renal reabsorption,and modifying nutrient diges-tion and absorption pathways.Conclusion In this study,we investigated the genetic diversity and population structure of 6 Tibetan sheep breeds in Qinghai Province,China.Additionally,we analyzed the domestication traits and investigated the unique adapta-tion mechanisms residing varying altitudes in the plateau region of Tibetan sheep.This study provides valuable insights into the evolutionary processes of Tibetan sheep in extreme environments.These findings will also contribute to the preservation of genetic diversity and offer a foundation for Tibetan sheep diversity preservation and plateau animal environmental adaptation mechanisms.
