DEFINITIONAcute diarrhoea is defined as passage of loose or waterystools at least three times in a 24 h period.When loosestools contain blood,it is called bloody diarrhoea(dysentery).It is the consistency of the stool...DEFINITIONAcute diarrhoea is defined as passage of loose or waterystools at least three times in a 24 h period.When loosestools contain blood,it is called bloody diarrhoea(dysentery).It is the consistency of the stools which ismost important rather than the frequency.Breast-fed babiesoften pass'pasty'stools frequently which is not diarrhoea.The raother can often tell accurately whether child hasdiarrhoea or not.展开更多
AIM： To investigate the changing pattern of different histological parameters occurring in the stomach tissue of Helicobacter pylori （H pylori） infected tribal populations and duodenal ulcer patients among ethnic B...AIM： To investigate the changing pattern of different histological parameters occurring in the stomach tissue of Helicobacter pylori （H pylori） infected tribal populations and duodenal ulcer patients among ethnic Bengalis and correlation of the genotypes of H pylori with different histological parameters. METHODS： One hundred and twelve adult individuals were enrolled into this study between 2002 and 2004. Among them, 72 had clinical features of duodenal ulcer （DU） from ethnic Bengali population and 40 were asymptomatic ethnic tribals. Endoscopic gastric biopsy samples were processed for histology, genotyping and rapid urease test. Histologically, haematoxylin and eosin staining was applied to assess the pathomorphological changes and a modified Giemsa staining was used for better detection of Hpylori. For intestinal metaplasia, special stainings, i.e. Alcian blue periodic acid-Schiff and high iron diamine-Alcian blue staining, were performed. PCR was performed on bacterial DNA to characterize the presence or absence of virulence-associated genes, like cagA, and distribution of different alleles of vacA and iceA. RESULTS： Intraglandular neutrophil infiltration, a hallmark of activity of gastritis, was present in 34 （94%） of tribals （TRs） and 42 （84%） of DU individuals infected with H pylori. Lymphoid follicles and aggregates, which are important landmarks in H pylori infection, were positive amongst 15 （41%） of TRs and 20 （40%） of DU subjects. Atrophic changes were observed in 60% and 27.7%, respectively, among DU cases and tribals （P 〉 0.003）. Metaplastic changes were detected in low numbers in both groups. Moderate to severe density distribution of Hpylori in the gastric mucosa was 63% among TRs, whereas it was 62% in DU subjects. There were no significant differences in the distribution of virulence-associated genes like cagA, vacA and iceA of H pylori strains carried by these two populations. CONCLUSION： Our study showed almost similar distribution of inflammatory cells among asymptomatic tribals and DU Bengali patients. Interestingly, the tribal population are free from any clinical symptoms despite evidence of active histologic gastritis and infection with Hpylori strains carrying similar virulence markers as of strains isolated from patients with DU. There was an increased cellular response, especially in terms of neutrophil infiltration, but much lower risk of developing atrophy and metaplastic changes among the tribal population.展开更多
Objective:To investigate the outbreak of unknown fever at Siliguri town,Darjeeling District on request from the State Health Department,Government of West Bengal.Methods: Investigations were made to the affected wards...Objective:To investigate the outbreak of unknown fever at Siliguri town,Darjeeling District on request from the State Health Department,Government of West Bengal.Methods: Investigations were made to the affected wards,Sub Divisional Hospital and the nursing homes of Siliguri Town.Duration of illness was 3-5 days.Interesting observations were made in some cases which had gastrointestinal disorders with high serum glutamate pyruvate transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SCOT) levels.A total of 69 blood samples and 7 throat swabs(in Minimum Essential Media) were collected and brought to the ICMR Virus Unit, Kolkata for analysis.Mosquitoes from different affected areas were collected for the identification of the definite vector.Results:Amongst the 69 blood samples,42(60.86%) were positive to IgM antibody against dengue virus by Mac enzyme-linked immunosorbent assay(ELISA) test.No IgM antibody to Japanese encephalitis virus was detected among the collected blood samples.Based on the clinical symptoms,presence of IgM antibody to dengue virus and identification of Aedes mosquito,it amply proves that,the illness of those cases were due to dengue virus infection. Conclusions:Based on clinical-epidemiological observations of the investigations the possibility of a communicable disease of viral origin,the detection of IgM antibody and the identification of Aedes egypti,and the potential circulation of denge virus in Siliguri town for the first time were all suggested.展开更多
谷歌的Android操作系统是被热烈讨论的市场热点，甚至有传言称其将被用于上网本上，但是谷歌手机软件也能用在Symbian S60平台手机上，这你知道吗？最近Googel Moble小组发布了Google Mobile App for S60，中文名叫“谷歌手机软件”，...谷歌的Android操作系统是被热烈讨论的市场热点，甚至有传言称其将被用于上网本上，但是谷歌手机软件也能用在Symbian S60平台手机上，这你知道吗？最近Googel Moble小组发布了Google Mobile App for S60，中文名叫“谷歌手机软件”，它有什么特点及功能，MI将带你一起去领略一下。展开更多
文摘DEFINITIONAcute diarrhoea is defined as passage of loose or waterystools at least three times in a 24 h period.When loosestools contain blood,it is called bloody diarrhoea(dysentery).It is the consistency of the stools which ismost important rather than the frequency.Breast-fed babiesoften pass'pasty'stools frequently which is not diarrhoea.The raother can often tell accurately whether child hasdiarrhoea or not.
基金Supported by The Indian Council of Medical Research, Government of India and Program of Founding Research Center for Emerging and Reemerging Infectious Diseases, Ministry of Education, Culture, Sports, Science and Technology of Japan
文摘AIM： To investigate the changing pattern of different histological parameters occurring in the stomach tissue of Helicobacter pylori （H pylori） infected tribal populations and duodenal ulcer patients among ethnic Bengalis and correlation of the genotypes of H pylori with different histological parameters. METHODS： One hundred and twelve adult individuals were enrolled into this study between 2002 and 2004. Among them, 72 had clinical features of duodenal ulcer （DU） from ethnic Bengali population and 40 were asymptomatic ethnic tribals. Endoscopic gastric biopsy samples were processed for histology, genotyping and rapid urease test. Histologically, haematoxylin and eosin staining was applied to assess the pathomorphological changes and a modified Giemsa staining was used for better detection of Hpylori. For intestinal metaplasia, special stainings, i.e. Alcian blue periodic acid-Schiff and high iron diamine-Alcian blue staining, were performed. PCR was performed on bacterial DNA to characterize the presence or absence of virulence-associated genes, like cagA, and distribution of different alleles of vacA and iceA. RESULTS： Intraglandular neutrophil infiltration, a hallmark of activity of gastritis, was present in 34 （94%） of tribals （TRs） and 42 （84%） of DU individuals infected with H pylori. Lymphoid follicles and aggregates, which are important landmarks in H pylori infection, were positive amongst 15 （41%） of TRs and 20 （40%） of DU subjects. Atrophic changes were observed in 60% and 27.7%, respectively, among DU cases and tribals （P 〉 0.003）. Metaplastic changes were detected in low numbers in both groups. Moderate to severe density distribution of Hpylori in the gastric mucosa was 63% among TRs, whereas it was 62% in DU subjects. There were no significant differences in the distribution of virulence-associated genes like cagA, vacA and iceA of H pylori strains carried by these two populations. CONCLUSION： Our study showed almost similar distribution of inflammatory cells among asymptomatic tribals and DU Bengali patients. Interestingly, the tribal population are free from any clinical symptoms despite evidence of active histologic gastritis and infection with Hpylori strains carrying similar virulence markers as of strains isolated from patients with DU. There was an increased cellular response, especially in terms of neutrophil infiltration, but much lower risk of developing atrophy and metaplastic changes among the tribal population.
文摘Objective:To investigate the outbreak of unknown fever at Siliguri town,Darjeeling District on request from the State Health Department,Government of West Bengal.Methods: Investigations were made to the affected wards,Sub Divisional Hospital and the nursing homes of Siliguri Town.Duration of illness was 3-5 days.Interesting observations were made in some cases which had gastrointestinal disorders with high serum glutamate pyruvate transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SCOT) levels.A total of 69 blood samples and 7 throat swabs(in Minimum Essential Media) were collected and brought to the ICMR Virus Unit, Kolkata for analysis.Mosquitoes from different affected areas were collected for the identification of the definite vector.Results:Amongst the 69 blood samples,42(60.86%) were positive to IgM antibody against dengue virus by Mac enzyme-linked immunosorbent assay(ELISA) test.No IgM antibody to Japanese encephalitis virus was detected among the collected blood samples.Based on the clinical symptoms,presence of IgM antibody to dengue virus and identification of Aedes mosquito,it amply proves that,the illness of those cases were due to dengue virus infection. Conclusions:Based on clinical-epidemiological observations of the investigations the possibility of a communicable disease of viral origin,the detection of IgM antibody and the identification of Aedes egypti,and the potential circulation of denge virus in Siliguri town for the first time were all suggested.
文摘谷歌的Android操作系统是被热烈讨论的市场热点，甚至有传言称其将被用于上网本上，但是谷歌手机软件也能用在Symbian S60平台手机上，这你知道吗？最近Googel Moble小组发布了Google Mobile App for S60，中文名叫“谷歌手机软件”，它有什么特点及功能，MI将带你一起去领略一下。
