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基于网络药理学策略探讨四君子汤治疗癌性恶病质的潜在机制 被引量:3
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作者 陈江锋 林芝娴 郭勇 《浙江中西医结合杂志》 2022年第2期122-128,共7页
目的基于网络药理学方法探讨四君子汤治疗癌性恶病质的可能机制。方法本研究采用一个全面的网络药理学策略,由四个顺序模块组成:靶点预测、网络构建、分子对接、GO和KEGG富集分析。结果四君子汤中的7,9(11)-dehydropachymic acid和Tarax... 目的基于网络药理学方法探讨四君子汤治疗癌性恶病质的可能机制。方法本研究采用一个全面的网络药理学策略,由四个顺序模块组成:靶点预测、网络构建、分子对接、GO和KEGG富集分析。结果四君子汤中的7,9(11)-dehydropachymic acid和Taraxerol化合物可能通过作用于INS,PCK2,FABP3,eIF4E,SKP1,CCND1,CTNNB1,STAT5A,IL6ST,AR,CYCS,VEGFA等靶点来调节PI3K-Akt信号通路和Wnt信号通路,发挥调节代谢和抑制肿瘤的作用,最终达到治疗癌性恶病质的目的。结论四君子汤通过多个化合物、多个靶点、多个通路的直接或间接协同作用,能够有效地治疗癌性恶病质。 展开更多
关键词 四君子汤 癌性恶病质 网络药理学 分子对接 潜在机制
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Fixed Point Approximation for Suzuki Generalized Nonexpansive Mapping Using B(δ, μ) Condition
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作者 Kamal Kumar Laxmi Rathour +1 位作者 Mukesh Kumar Sharma Vishnu Narayan Mishra 《Applied Mathematics》 2022年第2期215-227,共13页
In this paper, we introduce AK' iteration scheme to approximate fixed point for Suzuki generalized nonexpansive mapping satisfying B(δ, μ) condition in the framework of Banach spaces. Also, an example is given t... In this paper, we introduce AK' iteration scheme to approximate fixed point for Suzuki generalized nonexpansive mapping satisfying B(δ, μ) condition in the framework of Banach spaces. Also, an example is given to confirm the efficiency of AK' iteration scheme. Our results are generalizations in the existing literature of fixed points in Banach spaces. 展开更多
关键词 AK' Iterative Scheme B(δ μ) Condition Suzuki Genertalized Nonexpansive Mappings Banach Spaces
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On Almost Type α-F-Z-Weak Contraction in Metric Spaces
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作者 Jia Deng Xiaolan Liu +1 位作者 Yan Sun Laxmi Rathour 《Open Journal of Applied Sciences》 2022年第4期528-540,共13页
In this article, we introduce a new type of contraction named almost type α-F-Z-weak contraction, which comes from a combination of F-contraction, Z-contraction, and almost contraction, and then we provide sufficient... In this article, we introduce a new type of contraction named almost type α-F-Z-weak contraction, which comes from a combination of F-contraction, Z-contraction, and almost contraction, and then we provide sufficient conditions for the existence and uniqueness of fixed point of such contractions in complete metric spaces and give some related fixed point results. In addition, some related fixed point results can derive from our main results. 展开更多
关键词 Fixed Point α-Admissible α-F-Z-Weak Contraction Almost Contraction
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