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大鼠实验性牙周炎一氧化氮含量改变的研究(英文) 被引量:1
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作者 黄世光 谢敏 吕芳丽 《中国病理生理杂志》 CAS CSCD 北大核心 2005年第12期2470-2473,共4页
目的:通过建立大鼠牙周炎实验模型,测量牙龈组织中亚硝酸盐(NO2-)和硝酸盐(NO3-)的含量,比较一氧化氮(NO)含量与附着丧失(AL)的关系,探讨NO在牙周炎病理进程中的作用。方法:健康SPRAGUE-DAWLEY大鼠共72只,随机分为两组:正常对照组和牙... 目的:通过建立大鼠牙周炎实验模型,测量牙龈组织中亚硝酸盐(NO2-)和硝酸盐(NO3-)的含量,比较一氧化氮(NO)含量与附着丧失(AL)的关系,探讨NO在牙周炎病理进程中的作用。方法:健康SPRAGUE-DAWLEY大鼠共72只,随机分为两组:正常对照组和牙周炎组,每组36只。参照DI PAOLA法复制大鼠牙周炎动物模型。分别于术后1、4和8周时处死动物,每个时点每组处死的动物数为12只。采用分光光度仪测量大鼠牙龈组织中亚硝酸盐 (NO2-)和硝酸盐(NO3-)的含量,以间接确定NO含量;采用组织切片法观察牙周组织的组织学改变;应用TIGER细胞图像仪测量AL。结果:术后4周和8周时,实验性牙周炎组牙龈组织NO2-/NO3-含量明显高于正常对照组(P< 0.01);在牙周炎组,术后8周牙龈组织NO2-/NO3-含量明显高于术后4周(P<0.01)。在牙周炎组,术后4周和8周与术后1周比较,AL显著增加(P<0.01);术后8周与4周比较,AL显著增加(P<0.01)。结论:牙周炎组牙龈组织 NO2-/NO3-含量明显高于正常对照组;NO2-/NO3-含量与牙周组织的AL直接相关。结果表明NO在牙周组织的炎症和破坏过程中发挥作用,提示在牙周炎的治疗中控制NO具有临床应用价值。 展开更多
关键词 牙周炎 一氧化氮 附着丧失
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Efficient Origin-Destination Estimation Using Microscopic Traffic Simulation with Restricted Rerouting 被引量:1
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作者 Kazuki Abe Hideki Fujii Shinobu Yoshimura 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第5期1091-1109,共19页
Traffic simulators are utilized to solve a variety of traffic-related problems.For such simulators,origin-destination(OD)traffic volumes as mobility demands are required to input,and we need to estimate them.The autho... Traffic simulators are utilized to solve a variety of traffic-related problems.For such simulators,origin-destination(OD)traffic volumes as mobility demands are required to input,and we need to estimate them.The authors regard an OD estimation as a bi-level programming problem,and apply a microscopic traffic simulation model to it.However,the simulation trials can be computationally expensive if full dynamic rerouting is allowed,when employing multi-agent-based models in the estimation process.This paper proposes an efficient OD estimation method using a multi-agent-based simulator with restricted dynamic rerouting to reduce the computational load.Even though,in the case of large traffic demand,the restriction on dynamic rerouting can result in heavier congestion.The authors resolve this problem by introducing constraints of the bi-level programming problem depending on link congestion.Test results show that the accuracy of the link traffic volume reproduced with the proposed method is virtually identical to that of existing methods but that the proposed method is more computationally efficient in a wide-range or high-demand context. 展开更多
关键词 ODestimation microscopic traffic simulation dynamic rerouting bi-level programming multi-agent basedmodel
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