Nery do Vale诊所原空间氛围冷峻严肃,带有医疗空间常见的压迫感。一条没什么自然光的封闭走廊连接着拥挤的房间,布局草率,虽试图满足多种功能需求,却未设独立的诊室或公用茶水间。然而,设计师却发现这里蕴含着与户外、自然相连的巨大...Nery do Vale诊所原空间氛围冷峻严肃,带有医疗空间常见的压迫感。一条没什么自然光的封闭走廊连接着拥挤的房间,布局草率,虽试图满足多种功能需求,却未设独立的诊室或公用茶水间。然而,设计师却发现这里蕴含着与户外、自然相连的巨大潜力。因此,设计旨在营造一个宁静而温馨的环境,以缓解牙科诊疗给人带来的紧张感,在技术与感性,功能与关怀之间寻求平衡。展开更多
In this paper we consider the class of Bazilevic functions for bi-univalent functions. For this we will estimate the coefficients a2 and a3 using Caratheodory func- tions and the method of differential subordination.
The article attempts to explain part of a study that we are developing in the research titled: Higher Education andUrban and Regional Development: expressions of Public State Universities in Ceará. For the purpos...The article attempts to explain part of a study that we are developing in the research titled: Higher Education andUrban and Regional Development: expressions of Public State Universities in Ceará. For the purpose of this articlewe focus on the Teaching-Research-Extension tripod in the Vale do Acaraú State University (UVA), in 2018, yearthat UVA celebrates its fiftieh anniversary. Research occured through questionnaires sent to the graduates viaUVA’s academic system, created by the Information Technology Center (NTI). The questionnare solicited answersfrom 1785 graduates;Research also included an interview with the Dean of Administration, office of 2014-2022 aswell as data and institutional documents analysis from the university’s webpage and data collection in severalpro-rectory offices in the University. Besides its contradictions in the consolidation process, UVA plays a relevantrole in the expansion of Public Higher Education outside the capital of the brazilian Northeast region, especially inCeará, where the Federal University took fifty years to establish a campus outside the state capital. The Institution’spioneering spirit helped to reassure the prominent regional role of the city of Sobral in Ceará’s urban network,capturing a daily flow of students from over 55 counties.展开更多
Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephal...Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics.Methods::Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics.Results::Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015.Conclusion::This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.展开更多
BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To...BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To provide fair organ distribution,predictive mortality scores have been developed.AIM To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of mortality.METHODS Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to 2018.RESULTS The transplant recipients were mainly male,with a mean age of 58.1 years.Donors were mostly male,with a mean age of 41.6 years.The median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 days.For APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD 24.2.The 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<0.008.At 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and survivors.As for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.展开更多
Luminescent materials for application in temperature sensing have caught a lot of interest in recent years.Particularly erbium(Er^(3+))-doped fluoride-based materials(EFM),which are readily accessible by near-infrared...Luminescent materials for application in temperature sensing have caught a lot of interest in recent years.Particularly erbium(Er^(3+))-doped fluoride-based materials(EFM),which are readily accessible by near-infrared(NIR)excitation to produce efficient photon conversion.It has been established that ytterbium(Yb^(3+))may improve the performance of EFMs in both bulk and nanostructured forms by energy transfer channels among rare-earth ions in interstitial clusters.In this work,a comprehensive analysis of the Er^(3+):Yb^(3+):CaF_(2)crystalline structure,photoluminescence,and energy transfer from Yb^(3+)to Er^(3+)is presented for powders prepared by combustion synthesis.The Er^(3+):Yb^(3+):CaF_(2)powders display exceptional photon down-shift and up-conversion when exposed to NIR light(λ=975 nm).The luminescence spectral change of the NIR emission around 1.5μm,which corresponds to the Er^(3+)electronic transition ^(4)I_(13/2)→^(4)I_(15/2),was investigated in a temperature range of 298-423 K for application in temperature sensing of biological systems exploring the third biological window.The luminescence intensity ratio technique was applied to the thermally coupled Stark sublevels of states^(4)I_(13/2)and^(4)I_(15/2)with the highest estimated temperature relative sensitivity being around 0.4%/K at 298 K.展开更多
Due to the invisibility and complexity of the underground spaces,monitoring the propagation and filling characteristics of the grouting slurry post the water–sand mixture inrush in metal mines is challenging,which co...Due to the invisibility and complexity of the underground spaces,monitoring the propagation and filling characteristics of the grouting slurry post the water–sand mixture inrush in metal mines is challenging,which complicates engineering treatment.This research investigated the propagation law of cement-sodium silicate slurry under flowing water conditions within the caving mass of a metal mine.First,based on borehole packer test results and borehole TV images,the fractured strata before grouting were classified into four types:cavity,hidden,fissure,and complete.Second,an orthogonal experimental design was employed to evaluate the impact of four key factors—stratigraphic fragmentation,water flow rate,grouting flow rate,and water-cement ratio—on the efficacy of grouting within a caving mass at the site.The results indicate that the factors influencing grouting efficacy are ranked in the following order of importance:stratigraphic fragmentation>water flow rate>water–cement ratio>grouting flow rate.Ultimately,five propagation filling modes—pure slurry,big crack,small crack,small karst pore,and pore penetration—were identified by examining the propagation filling characteristics of slurry in rock samples,incorporating microscopic material structure analysis through scanning electron microscopy and energy spectrum analysis.The findings of this study provide valuable insights into selecting engineering treatment parameters and methodologies,serving as a reference for preventing and controlling water–sand mixture inrush in metal mines,thereby enhancing treatment efficacy and ensuring grouting success.展开更多
Performing the high-resolution stratigraphic analysis may be challenging and time-consuming if one has to work with large datasets.Moreover,sedimentary records have signals of different frequencies and intrinsic noise...Performing the high-resolution stratigraphic analysis may be challenging and time-consuming if one has to work with large datasets.Moreover,sedimentary records have signals of different frequencies and intrinsic noise,resulting in a complex signature that is difficult to identify only through eyes-based analysis.This work proposes identifying transgressive-regressive(T-R)sequences from carbonate facies successions of three South American basins:(i)São Francisco Basin-Brazil,(ii)Santos Basin-Brazil,and(iii)Salta Basin-Argentina.We applied a hidden Markov model in an unsupervised approach followed by a Score-Based Recommender System that automatically finds medium or low-frequency sedimentary cycles from high-frequency ones.Our method is applied to facies identified using Fullbore Formation Microimager(FMI)logs,outcrop description,and composite logs from carbonate intervals.The automatic recommendation results showed better long-distance correlations between medium-to low-frequency sedimentary cycles,whereas the hidden Markov model method successfully identified high-resolution(high-frequency)transgressive and regressive systems tracts from the given facies successions.Our workflow offers advances in the automated analyses and construction of to lower-higher-rank stratigraphic framework and short to long-distance stratigraphic correlation,allowing for scale large-automated processing of the basin dataset.Our approach in this work fits the unsupervised learning framework,as we require no previous input of stratigraphical analysis in the basin.The results provide solutions for prospecting any sediment-hosted mineral resource,especially for the oil and gas industry,offering support for subsurface geological characterization,whether at the exploration scale or for reservoir zoning during production development.展开更多
Conventional borehole image log interpretation of linear fractures on volcanic rocks,represented as sinusoids on unwrapped cylinder projections,is relatively straight-forward,however,interpreting non-linear rock struc...Conventional borehole image log interpretation of linear fractures on volcanic rocks,represented as sinusoids on unwrapped cylinder projections,is relatively straight-forward,however,interpreting non-linear rock structures and complex facies geometries can be more challenging.To characterize diverse volcanic paleoenvironments related to the formation of the South American continent,this study presents a new methodology based on image logs,petrography,seismic data,and outcrop analogues.The presented methodology used pseudo-boreholes images generated from outcrop photographs with typical igneous rock features worldwide simulating 2D unwrapped cylinder projections of a 31 cm(12.25 in)diameter well.These synthetic images and standard outcrop photographs were used to define morphological patterns of igneous structures and facies for comparison with wireline borehole image logs from subsurface volcanic and subvolcanic units,providing a“visual scale”for geological evaluation of volcanic facies,significantly enhancing the identification efficiency and reliability of complex geological structures.Our analysis focused on various scales of columnar jointing and pillow lava lobes with additional examples including pahoehoe lava,ignimbrite,hyaloclastite,and various intrusive features in Campos,Santos,and Parnaíba basins in Brazil.This approach increases confidence in the interpretation of subvolcanic,subaerial,and subaqueous deposits.The image log interpretation combined with regional geological knowledge has enabled paleoenvironmental insights into the rift magmatism system related to the breakup of Gondwana with associated implications for hydrocarbon exploration.展开更多
BACKGROUND Papillary thyroid cancer(PTC)often recurs following surgical excision,necessitating reliable long-term screening techniques after initial management.Ultrasound scans have a poor predictive value and biopsy ...BACKGROUND Papillary thyroid cancer(PTC)often recurs following surgical excision,necessitating reliable long-term screening techniques after initial management.Ultrasound scans have a poor predictive value and biopsy and genetic testing have a low sensitivity.Biomarker detection,including thyroglobulin,has reduced accuracy as residual thyroid tissue remains following surgery.Serum/tissue microRNA detection offers a promising alternative to screen for thyroid malignancy.Based on our previous systematic review,miR-146,miR-221 and miR-222 appear most strongly associated with PTC.AIM To perform a systematic review and meta-analysis,evaluating the use of circulating miR-146,miRNA-221 and miR-222 in PTC diagnosis and staging.METHODS A systematic literature search of MEDLINE,Scopus and the EMBASE library was performed.Human participants of any age,sex or geographical distribution were considered.Original studies assessing the diagnostic and prognostic accuracy of circulating serum miRNAs in histologically-confirmed PTC were included.Proportion and regression meta-analyses(logit-transformed)were conducted.PRISMA guidelines were followed throughout the process.RESULTS Among the 1530 studies screened,6 met the inclusion criteria,reporting non-overlapping populations.For the diagnosis of PTC vs benign nodules(BN),the pooled sensitivity of miR-146 was 80.7%(95%CI:65.2%-90.4%),specificity was 66.9%(95%CI:55.5%-76.6%),and false positive rate was 33.1%(95%CI:23.4%-44.5%).Pooled sensitivity,specificity and false positive rate of miR-222 for diagnosis of PTC vs BN was 64.3%(95%CI:50.3%-76.2%),88.8%(95%CI:82.4%-93%)and 11.2%(95%CI:7%-17.6%)respectively.Pooled sensitivity,specificity and false positive rate of miR-221 in this population demonstrated reduced accuracy.Pooled sensitivity and specificity of PTC vs healthy controls for total serum miRNAs were 82%(95%CI:77%-86%)and 84%(95%CI:76%-90%)respectively.The summary area under receiver operating characteristic curve value for the same analysis was 0.89(95%CI:0.86-0.92).CONCLUSION miRNA-146 and miRNA-222 were most sensitive,validating their efficacy in PTC diagnosis.Larger studies are needed for confident population generalisability.Use of two-MRNA types in conjunction needs to be assessed.展开更多
Background Recovery colleges (RCs) support personal recovery through education, skill development and social support for people with mental health problems, carers and staff. Guided by co-production and adult learning...Background Recovery colleges (RCs) support personal recovery through education, skill development and social support for people with mental health problems, carers and staff. Guided by co-production and adult learning principles, RCs represent a recent mental health innovation. Since the first RC opened in England in 2009, RCs have expanded to 28 countries and territories. However, most RC research has been conducted in Western countries with similar cultural characteristics, limiting understanding of how RCs can be culturally adapted. The 12-item Recovery Colleges Characterisation and Testing (RECOLLECT) Fidelity Measure (RFM) evaluates the operational fidelity of RCs based on 12 components, but cultural influences on these components remain underexplored.Aims To assess associations between Hofstede’s cultural dimensions and RFM items to identify cultural influences on fidelity components.Methods A cross-sectional survey of RC managers was conducted across all 221 RCs. Mixed-effects regression models examined associations between Hofstede’s country-level cultural dimensions and item-level RFM scores, adjusted for healthcare expenditure and income inequality. Four cultural dimensions, obtained from Hofstede, were analysed: individualism (prioritising personal needs), indulgence (enjoyment-oriented), uncertainty avoidance (preference for predictability) and long-term orientation (future-focused).Results The RFM was completed by 169 (76%) RC managers. Seven RFM items showed associations with cultural dimensions. Equality was linked to short-term orientation, while learning was associated with individualism and uncertainty avoidance. Both individualism and indulgence influenced co-production and community focus. Commitment to recovery was shaped by all four cultural dimensions, with the strongest associations seen for individualism and indulgence. Individualism enhanced explicit focus on strengths-based practice, while uncertainty avoidance influenced course distinctiveness.Conclusions This study demonstrates how culture shapes RC fidelity components, providing actionable insights for cultural adaptation. Incorporating under-represented dimensions, such as collectivism and restraint, could improve the RFM’s global applicability, facilitating implementation. Future research should explore cultural nuances, engage diverse stakeholders and refine fidelity measures to enhance RC inclusivity and effectiveness worldwide.展开更多
An ore-blending optimization model for the sintering process is an intelligent system that includes iron ore characteristics, expert knowledge and material balance. In the present work, 14 indices are proposed to repr...An ore-blending optimization model for the sintering process is an intelligent system that includes iron ore characteristics, expert knowledge and material balance. In the present work, 14 indices are proposed to represent chemical composition, granulating properties and high temperature properties of iron ores. After the relationships between iron ore characteristics and sintering performance are established, the ＂two-step＂ method and the simplex method are introduced to build the model by distinguishing the calculation of optimized blending proportion of iron ores from that of other sintering materials in order to improve calculation efficiency. The ore-blending optimization model, programmed by Access and Visual Basic, is applied to practical production in steel mills and the results prove that the present model can take advantage of the available iron ore resource with stable sinter yield and quality performance but at a lower cost.展开更多
Gastric cancer accounts for a significant proportion of worldwide cancer-related morbidity and mortality.The well documented precancerous cascade provides an opportunity for clinicians to detect and treat gastric canc...Gastric cancer accounts for a significant proportion of worldwide cancer-related morbidity and mortality.The well documented precancerous cascade provides an opportunity for clinicians to detect and treat gastric cancers at an endoscopically curable stage.In high prevalence regions such as Japan and Korea,this has led to the implementation of population screening programs.However,guidelines remain ambiguous in lower prevalence regions.In recent years,there have been many advances in the endoscopic diagnosis and treatment of early gastric cancer and precancerous lesions.More advanced endoscopic imaging has led to improved detection and characterization of gastric lesions as well as superior accuracy for delineation of margins prior to resection.In addition,promising early data on artificial intelligence in gastroscopy suggests a future role for this technology in maximizing the yield of advanced endoscopic imaging.Data on endoscopic resection(ER)are particularly robust in Japan and Korea,with high rates of curative ER and markedly reduced procedural morbidity.However,there is a shortage of data in other regions to support the applicability of protocols from these high prevalence countries.Future advances in endoscopic therapeutics will likely lead to further expansion of the current indications for ER,as both technology and proceduralist expertise continue to grow.展开更多
Santalum album （Indian Sandalwood） is found in the mountainous regions of the intermediate zone of Sri Lanka. Few studies have been conducted on sandalwood ecology in this region, and ours is the first recorded stud...Santalum album （Indian Sandalwood） is found in the mountainous regions of the intermediate zone of Sri Lanka. Few studies have been conducted on sandalwood ecology in this region, and ours is the first recorded study of essential oil content and chemical composition of heartwood. We harvested two trees with State permission and took cross-sections for analysis. We demonstrated a difference in the heartwood formation and oil yield of the trees. The composition of the oil was found to be consistent between trees and along the trunk of the tree. Main aromatic compounds were santalols and other compounds are recorded in lesser quantities. Results of this study comply with the other published work on sandalwood elsewhere. This initial study on S. album in Sri Lanka provided promising results for the future of sandalwood agroforestry.展开更多
文摘Nery do Vale诊所原空间氛围冷峻严肃,带有医疗空间常见的压迫感。一条没什么自然光的封闭走廊连接着拥挤的房间,布局草率,虽试图满足多种功能需求,却未设独立的诊室或公用茶水间。然而,设计师却发现这里蕴含着与户外、自然相连的巨大潜力。因此,设计旨在营造一个宁静而温馨的环境,以缓解牙科诊疗给人带来的紧张感,在技术与感性,功能与关怀之间寻求平衡。
文摘In this paper we consider the class of Bazilevic functions for bi-univalent functions. For this we will estimate the coefficients a2 and a3 using Caratheodory func- tions and the method of differential subordination.
文摘The article attempts to explain part of a study that we are developing in the research titled: Higher Education andUrban and Regional Development: expressions of Public State Universities in Ceará. For the purpose of this articlewe focus on the Teaching-Research-Extension tripod in the Vale do Acaraú State University (UVA), in 2018, yearthat UVA celebrates its fiftieh anniversary. Research occured through questionnaires sent to the graduates viaUVA’s academic system, created by the Information Technology Center (NTI). The questionnare solicited answersfrom 1785 graduates;Research also included an interview with the Dean of Administration, office of 2014-2022 aswell as data and institutional documents analysis from the university’s webpage and data collection in severalpro-rectory offices in the University. Besides its contradictions in the consolidation process, UVA plays a relevantrole in the expansion of Public Higher Education outside the capital of the brazilian Northeast region, especially inCeará, where the Federal University took fifty years to establish a campus outside the state capital. The Institution’spioneering spirit helped to reassure the prominent regional role of the city of Sobral in Ceará’s urban network,capturing a daily flow of students from over 55 counties.
基金INAGEMP-National Institute of Population Medical Genetics grant CNPq(465549/2014-4)CAPES(88887.136366/2017-00)+2 种基金FAPERGS(17/2551-0000521-0)Project: Zika vírus: Uma abordagem translacional(CNPq grant 440763/2016-9)Project: A História Natural do Zika Vírus(Ministry of Health grant 929698560001160-02)
文摘Objective::Prenatal infection with the Zika virus (ZIKV) can lead to congenital Zika syndrome (CZS), characterized by microcephaly and brain injury. However, there are questions regarding the prevalence of microcephaly/CZS after the ZIKV outbreak in defined geographic areas. This study aimed to identify adverse outcomes in live births of fetuses exposed in utero to the ZIKV, compared to unexposed births, as well as maternal sociodemographic, delivery, and birth characteristics.Methods::Here, we conducted a cross-sectional observational study to investigate the characteristics of all live births in the city of Tangará da Serra, Mato Grosso, Brazil, in 2016, after the outbreak of ZIKV infection in late 2015. All live births of children to women residing in the municipality of Tangará da Serra between January 1 and December 31, 2016, were evaluated, and head circumference was measured at birth and after 24 hours. Children born with microcephaly or a maternal history of confirmed or suspected prenatal ZIKV infection were evaluated by a multidisciplinary team. The outcomes of the exposed and non-exposed children were compared. Prevalence ratios and their respective 95% confidence intervals were calculated for sociodemographic, delivery, and live birth characteristics.Results::Of 1,441 live births, 106 (7.3%) were from mothers with confirmed or highly probable exposure to ZIKV. The prevalence of severe congenital microcephaly (41.7/10,000) in Tangará da Serra in 2016 was ten-fold higher than that in Latin America before 2015.Conclusion::This study may serve as a model to investigate possible outbreaks of infections in a defined geographical space in the future.
文摘BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of life.The number of organs available for transplantation is lower than the demand.To provide fair organ distribution,predictive mortality scores have been developed.AIM To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of mortality.METHODS Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to 2018.RESULTS The transplant recipients were mainly male,with a mean age of 58.1 years.Donors were mostly male,with a mean age of 41.6 years.The median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 days.For APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD 24.2.The 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<0.008.At 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and survivors.As for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.
基金Project supported in part by the Brazilian Agency Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)。
文摘Luminescent materials for application in temperature sensing have caught a lot of interest in recent years.Particularly erbium(Er^(3+))-doped fluoride-based materials(EFM),which are readily accessible by near-infrared(NIR)excitation to produce efficient photon conversion.It has been established that ytterbium(Yb^(3+))may improve the performance of EFMs in both bulk and nanostructured forms by energy transfer channels among rare-earth ions in interstitial clusters.In this work,a comprehensive analysis of the Er^(3+):Yb^(3+):CaF_(2)crystalline structure,photoluminescence,and energy transfer from Yb^(3+)to Er^(3+)is presented for powders prepared by combustion synthesis.The Er^(3+):Yb^(3+):CaF_(2)powders display exceptional photon down-shift and up-conversion when exposed to NIR light(λ=975 nm).The luminescence spectral change of the NIR emission around 1.5μm,which corresponds to the Er^(3+)electronic transition ^(4)I_(13/2)→^(4)I_(15/2),was investigated in a temperature range of 298-423 K for application in temperature sensing of biological systems exploring the third biological window.The luminescence intensity ratio technique was applied to the thermally coupled Stark sublevels of states^(4)I_(13/2)and^(4)I_(15/2)with the highest estimated temperature relative sensitivity being around 0.4%/K at 298 K.
基金The National Natural Science Foundation of China,Grant/Award Number:42130706。
文摘Due to the invisibility and complexity of the underground spaces,monitoring the propagation and filling characteristics of the grouting slurry post the water–sand mixture inrush in metal mines is challenging,which complicates engineering treatment.This research investigated the propagation law of cement-sodium silicate slurry under flowing water conditions within the caving mass of a metal mine.First,based on borehole packer test results and borehole TV images,the fractured strata before grouting were classified into four types:cavity,hidden,fissure,and complete.Second,an orthogonal experimental design was employed to evaluate the impact of four key factors—stratigraphic fragmentation,water flow rate,grouting flow rate,and water-cement ratio—on the efficacy of grouting within a caving mass at the site.The results indicate that the factors influencing grouting efficacy are ranked in the following order of importance:stratigraphic fragmentation>water flow rate>water–cement ratio>grouting flow rate.Ultimately,five propagation filling modes—pure slurry,big crack,small crack,small karst pore,and pore penetration—were identified by examining the propagation filling characteristics of slurry in rock samples,incorporating microscopic material structure analysis through scanning electron microscopy and energy spectrum analysis.The findings of this study provide valuable insights into selecting engineering treatment parameters and methodologies,serving as a reference for preventing and controlling water–sand mixture inrush in metal mines,thereby enhancing treatment efficacy and ensuring grouting success.
文摘Performing the high-resolution stratigraphic analysis may be challenging and time-consuming if one has to work with large datasets.Moreover,sedimentary records have signals of different frequencies and intrinsic noise,resulting in a complex signature that is difficult to identify only through eyes-based analysis.This work proposes identifying transgressive-regressive(T-R)sequences from carbonate facies successions of three South American basins:(i)São Francisco Basin-Brazil,(ii)Santos Basin-Brazil,and(iii)Salta Basin-Argentina.We applied a hidden Markov model in an unsupervised approach followed by a Score-Based Recommender System that automatically finds medium or low-frequency sedimentary cycles from high-frequency ones.Our method is applied to facies identified using Fullbore Formation Microimager(FMI)logs,outcrop description,and composite logs from carbonate intervals.The automatic recommendation results showed better long-distance correlations between medium-to low-frequency sedimentary cycles,whereas the hidden Markov model method successfully identified high-resolution(high-frequency)transgressive and regressive systems tracts from the given facies successions.Our workflow offers advances in the automated analyses and construction of to lower-higher-rank stratigraphic framework and short to long-distance stratigraphic correlation,allowing for scale large-automated processing of the basin dataset.Our approach in this work fits the unsupervised learning framework,as we require no previous input of stratigraphical analysis in the basin.The results provide solutions for prospecting any sediment-hosted mineral resource,especially for the oil and gas industry,offering support for subsurface geological characterization,whether at the exploration scale or for reservoir zoning during production development.
文摘Conventional borehole image log interpretation of linear fractures on volcanic rocks,represented as sinusoids on unwrapped cylinder projections,is relatively straight-forward,however,interpreting non-linear rock structures and complex facies geometries can be more challenging.To characterize diverse volcanic paleoenvironments related to the formation of the South American continent,this study presents a new methodology based on image logs,petrography,seismic data,and outcrop analogues.The presented methodology used pseudo-boreholes images generated from outcrop photographs with typical igneous rock features worldwide simulating 2D unwrapped cylinder projections of a 31 cm(12.25 in)diameter well.These synthetic images and standard outcrop photographs were used to define morphological patterns of igneous structures and facies for comparison with wireline borehole image logs from subsurface volcanic and subvolcanic units,providing a“visual scale”for geological evaluation of volcanic facies,significantly enhancing the identification efficiency and reliability of complex geological structures.Our analysis focused on various scales of columnar jointing and pillow lava lobes with additional examples including pahoehoe lava,ignimbrite,hyaloclastite,and various intrusive features in Campos,Santos,and Parnaíba basins in Brazil.This approach increases confidence in the interpretation of subvolcanic,subaerial,and subaqueous deposits.The image log interpretation combined with regional geological knowledge has enabled paleoenvironmental insights into the rift magmatism system related to the breakup of Gondwana with associated implications for hydrocarbon exploration.
文摘BACKGROUND Papillary thyroid cancer(PTC)often recurs following surgical excision,necessitating reliable long-term screening techniques after initial management.Ultrasound scans have a poor predictive value and biopsy and genetic testing have a low sensitivity.Biomarker detection,including thyroglobulin,has reduced accuracy as residual thyroid tissue remains following surgery.Serum/tissue microRNA detection offers a promising alternative to screen for thyroid malignancy.Based on our previous systematic review,miR-146,miR-221 and miR-222 appear most strongly associated with PTC.AIM To perform a systematic review and meta-analysis,evaluating the use of circulating miR-146,miRNA-221 and miR-222 in PTC diagnosis and staging.METHODS A systematic literature search of MEDLINE,Scopus and the EMBASE library was performed.Human participants of any age,sex or geographical distribution were considered.Original studies assessing the diagnostic and prognostic accuracy of circulating serum miRNAs in histologically-confirmed PTC were included.Proportion and regression meta-analyses(logit-transformed)were conducted.PRISMA guidelines were followed throughout the process.RESULTS Among the 1530 studies screened,6 met the inclusion criteria,reporting non-overlapping populations.For the diagnosis of PTC vs benign nodules(BN),the pooled sensitivity of miR-146 was 80.7%(95%CI:65.2%-90.4%),specificity was 66.9%(95%CI:55.5%-76.6%),and false positive rate was 33.1%(95%CI:23.4%-44.5%).Pooled sensitivity,specificity and false positive rate of miR-222 for diagnosis of PTC vs BN was 64.3%(95%CI:50.3%-76.2%),88.8%(95%CI:82.4%-93%)and 11.2%(95%CI:7%-17.6%)respectively.Pooled sensitivity,specificity and false positive rate of miR-221 in this population demonstrated reduced accuracy.Pooled sensitivity and specificity of PTC vs healthy controls for total serum miRNAs were 82%(95%CI:77%-86%)and 84%(95%CI:76%-90%)respectively.The summary area under receiver operating characteristic curve value for the same analysis was 0.89(95%CI:0.86-0.92).CONCLUSION miRNA-146 and miRNA-222 were most sensitive,validating their efficacy in PTC diagnosis.Larger studies are needed for confident population generalisability.Use of two-MRNA types in conjunction needs to be assessed.
基金This study is part of the RECOLLECT 2 programme,a five-year(2020-2025)project funded by the National Institute for Health and Care Research,which investigates the effectiveness and cost-effectiveness of recovery colleges.
文摘Background Recovery colleges (RCs) support personal recovery through education, skill development and social support for people with mental health problems, carers and staff. Guided by co-production and adult learning principles, RCs represent a recent mental health innovation. Since the first RC opened in England in 2009, RCs have expanded to 28 countries and territories. However, most RC research has been conducted in Western countries with similar cultural characteristics, limiting understanding of how RCs can be culturally adapted. The 12-item Recovery Colleges Characterisation and Testing (RECOLLECT) Fidelity Measure (RFM) evaluates the operational fidelity of RCs based on 12 components, but cultural influences on these components remain underexplored.Aims To assess associations between Hofstede’s cultural dimensions and RFM items to identify cultural influences on fidelity components.Methods A cross-sectional survey of RC managers was conducted across all 221 RCs. Mixed-effects regression models examined associations between Hofstede’s country-level cultural dimensions and item-level RFM scores, adjusted for healthcare expenditure and income inequality. Four cultural dimensions, obtained from Hofstede, were analysed: individualism (prioritising personal needs), indulgence (enjoyment-oriented), uncertainty avoidance (preference for predictability) and long-term orientation (future-focused).Results The RFM was completed by 169 (76%) RC managers. Seven RFM items showed associations with cultural dimensions. Equality was linked to short-term orientation, while learning was associated with individualism and uncertainty avoidance. Both individualism and indulgence influenced co-production and community focus. Commitment to recovery was shaped by all four cultural dimensions, with the strongest associations seen for individualism and indulgence. Individualism enhanced explicit focus on strengths-based practice, while uncertainty avoidance influenced course distinctiveness.Conclusions This study demonstrates how culture shapes RC fidelity components, providing actionable insights for cultural adaptation. Incorporating under-represented dimensions, such as collectivism and restraint, could improve the RFM’s global applicability, facilitating implementation. Future research should explore cultural nuances, engage diverse stakeholders and refine fidelity measures to enhance RC inclusivity and effectiveness worldwide.
文摘An ore-blending optimization model for the sintering process is an intelligent system that includes iron ore characteristics, expert knowledge and material balance. In the present work, 14 indices are proposed to represent chemical composition, granulating properties and high temperature properties of iron ores. After the relationships between iron ore characteristics and sintering performance are established, the ＂two-step＂ method and the simplex method are introduced to build the model by distinguishing the calculation of optimized blending proportion of iron ores from that of other sintering materials in order to improve calculation efficiency. The ore-blending optimization model, programmed by Access and Visual Basic, is applied to practical production in steel mills and the results prove that the present model can take advantage of the available iron ore resource with stable sinter yield and quality performance but at a lower cost.
文摘Gastric cancer accounts for a significant proportion of worldwide cancer-related morbidity and mortality.The well documented precancerous cascade provides an opportunity for clinicians to detect and treat gastric cancers at an endoscopically curable stage.In high prevalence regions such as Japan and Korea,this has led to the implementation of population screening programs.However,guidelines remain ambiguous in lower prevalence regions.In recent years,there have been many advances in the endoscopic diagnosis and treatment of early gastric cancer and precancerous lesions.More advanced endoscopic imaging has led to improved detection and characterization of gastric lesions as well as superior accuracy for delineation of margins prior to resection.In addition,promising early data on artificial intelligence in gastroscopy suggests a future role for this technology in maximizing the yield of advanced endoscopic imaging.Data on endoscopic resection(ER)are particularly robust in Japan and Korea,with high rates of curative ER and markedly reduced procedural morbidity.However,there is a shortage of data in other regions to support the applicability of protocols from these high prevalence countries.Future advances in endoscopic therapeutics will likely lead to further expansion of the current indications for ER,as both technology and proceduralist expertise continue to grow.
基金the financial support provided by Sadaharitha Plantations Ltdservices provided by Wescorp Sandalwood Ltd
文摘Santalum album （Indian Sandalwood） is found in the mountainous regions of the intermediate zone of Sri Lanka. Few studies have been conducted on sandalwood ecology in this region, and ours is the first recorded study of essential oil content and chemical composition of heartwood. We harvested two trees with State permission and took cross-sections for analysis. We demonstrated a difference in the heartwood formation and oil yield of the trees. The composition of the oil was found to be consistent between trees and along the trunk of the tree. Main aromatic compounds were santalols and other compounds are recorded in lesser quantities. Results of this study comply with the other published work on sandalwood elsewhere. This initial study on S. album in Sri Lanka provided promising results for the future of sandalwood agroforestry.
