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神经纤维瘤病Ⅰ型新致病基因突变1例并文献复习 被引量:1
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作者 张瑾 亓志玲 +3 位作者 王少华 赵玉凤 马旭 吴允刚 《山东大学耳鼻喉眼学报》 CAS 2024年第2期73-78,共6页
目的通过总结1例神经纤维瘤病Ⅰ型(neurofibromatosis typeⅠ,NFⅠ)新致病基因突变患者的临床资料,提高对NFI的认识及诊疗效果。方法回顾性分析1例15岁NFⅠ患者,并结合相关文献进行总结。结果本文NFⅠ患者有双侧耳部肿物,全身散在大小... 目的通过总结1例神经纤维瘤病Ⅰ型(neurofibromatosis typeⅠ,NFⅠ)新致病基因突变患者的临床资料,提高对NFI的认识及诊疗效果。方法回顾性分析1例15岁NFⅠ患者,并结合相关文献进行总结。结果本文NFⅠ患者有双侧耳部肿物,全身散在大小不等的皮肤斑块,双侧颌面部、颈部、颏下软组织肿胀,脊柱侧弯,其父亲有类似病史。基因检测发现1个新的突变位点。患者行耳部肿物切除术后恢复良好。结论临床上对NFⅠ患者,应追溯NFⅠ患者其家族史,并进行详细问诊及系统体格检查,检查患者有无合并恶性肿瘤,同时不要忽视患者的心理健康。尽管NFⅠ没有治愈的方法,但对于有明显症状、影响患者生活以及恶变的病例,可建议手术治疗。对于NFⅠ患者,应定期随访复查,关心心理健康,对其家庭进行遗传咨询和教育。 展开更多
关键词 Ⅰ型神经纤维瘤病 耳郭 基因检测 基因突变 青少年
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Numerical Investigation of Convective Heat Transfer and Friction in Solar Air Heater with Thin Ribs 被引量:1
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作者 Sanjay K.Sharma V.R.Kalamkar 《Computer Modeling in Engineering & Sciences》 SCIE EI 2018年第3期295-319,共25页
The three-dimensional numerical investigation of an incompressible flow through rib roughened solar air heater is carried out.A combination of thin transverse and truncated ribs is attached on the absorber plate to st... The three-dimensional numerical investigation of an incompressible flow through rib roughened solar air heater is carried out.A combination of thin transverse and truncated ribs is attached on the absorber plate to study its effect on the heat transfer and friction factor.The parameters in the form of Reynolds number(Re)of 4000-16000,relative roughness pitch(P/e)of 8-18 and relative roughness height(e/Dh)of 0.0366-0.055 is considered for the analysis.The CFD code ANSYS FLUENT is used to solve the governing equations of turbulent flow.The RNG k-εturbulence model is used to solve the transport equations with enhanced wall treatment,keeping the Y+<1.The maximum enhancement ratio of the Nusselt number and friction factor obtained is 1.91 and 3.61 respectively.The detailed investigation on average heat transfer,friction factor and flow structures have been discussed. 展开更多
关键词 CFD 3D heat transfer FRICTION FACTOR
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Mitigating phytotoxicity of tetracycline by metal-free 8-hydroxyquinoline functionalized carbon nitride photocatalyst 被引量:1
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作者 Toshali Bhoyar Devthade Vidyasagar Suresh S.Umare 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2023年第3期37-46,共10页
Photooxidative removal of pharmaceuticals and organic dyes is an effective way to eliminate growing micropollutants. However, photooxidation often results in byproducts as secondary hazardous substances such as phytot... Photooxidative removal of pharmaceuticals and organic dyes is an effective way to eliminate growing micropollutants. However, photooxidation often results in byproducts as secondary hazardous substances such as phytotoxins. Herein, we found that photooxidation of common antibiotic tetracycline hydrochloride(TCH) over a metal-free 8-hydroxyquinoline(8-HQ) functionalized carbon nitride(CN) photocatalyst significantly reduces the TCH phytotoxic effect. The phytotoxicity test of photocatalytic treated TCH-solution evaluated towards seed growth of Cicer arietinum plant model endowed natural root and shoot growth.This study highlights the conceptual insights in designing of metal-free photocatalyst for environmental remediation. 展开更多
关键词 Carbon nitride 8-HYDROXYQUINOLINE Tetracycline hydrochloride PHOTOCATALYST PHYTOTOXICITY Cicer arietinum
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An investigation on the hardness and corrosion behavior of MWCNT/Mg composites and grain refined Mg 被引量:8
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作者 N.Saikrishna G.Pradeep Kumar Reddy +3 位作者 Balakrishnan Munirathinam Ravikumar Dumpala M.Jagannatham B.Ratna Sunil 《Journal of Magnesium and Alloys》 SCIE EI CAS 2018年第1期83-89,共7页
In the present work,multi walled carbon nanotubes(MWCNT)reinforced magnesium(Mg)matrix composite was fabricated by friction stir processing(FSP)with an aim to explore its mechanical and electrochemical behavior.Micros... In the present work,multi walled carbon nanotubes(MWCNT)reinforced magnesium(Mg)matrix composite was fabricated by friction stir processing(FSP)with an aim to explore its mechanical and electrochemical behavior.Microstructural observations showed that the thickness of the produced composite layer was in the range of 2500μm.FSP resulted uniform distribution of CNT near the surface while agglomerated layers in the subsurface.Grain refinement of Mg achieved by FSP improved the hardness but significant enhancement in the hardness value was observed for FSPed MWCNT/Mg composites.Potentiodynamic polarization studies revealed that the increase in corrosion current density was observed for MWCNT/Mg composite compared with grain refined Mg and pure Mg,implying the significance of secondary phase(MWCNT)in decreasing the corrosion resistance of the composite. 展开更多
关键词 Friction stir processing MWCNT/Mg composite HARDNESS Basal texture Corrosion resistance
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Recent advances in the in-plane shear testing of Mg alloy sheets 被引量:3
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作者 Mahesh Panchal Lalit Kaushik +3 位作者 Ravi K.R Rajesh Khatirkar Shi-Hoon Choi Jaiveer Singh 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2023年第2期405-424,共20页
Sheet-metal products are integral parts of engineering industries and academia research. Various testing techniques have revealed the deformation behaviors of sheet metals under complex stress states. Information obta... Sheet-metal products are integral parts of engineering industries and academia research. Various testing techniques have revealed the deformation behaviors of sheet metals under complex stress states. Information obtained from tensile and compression tests, however, are insufficient for the identification of material parameters relevant to modern constitutive laws, which require experimental setups capable of generating various loading conditions and applying great amounts of strain to sheet metals. In-plane shear testing has emerged as an important method to overcome the challenges associated with tension and compression tests and can provide additional information about deformation behaviors under large plastic strains. Materials such as Mg alloys with poor levels of both ductility and formability cannot accommodate large plastic strains. Therefore, tension and compression tests have limitations in explaining the material behaviors that occur during sheet metal forming where large plastic strains are introduced. Many studies have been conducted to explain the deformation behaviors of Mg alloys under shear deformation techniques. These include severe plastic deformation(SPD), especially the equal channel angular pressing(ECAP)and equal channel angular extrusion, rolling combined with shear deformation i.e. differential speed rolling(DSR), and also in-plane shear for sheet metals, particularly under large levels of plastic strain. These in-plane shear technique involves the Miyauchi shear test, ASTM shear test, and twin bridge shear tests. Moreover, many experimental results have revealed that the evolution of microstructure and texture during in-plane shear is closely related to the failure behavior of materials. Therefore, this review is focused on techniques for in-plane shear testing that have been reported thus far, on the effect of in-plane shear on the microstructure development of Mg alloy sheets, and on the usefulness of in-plane shear testing to evaluate the formability of Mg alloy sheets. 展开更多
关键词 Mg alloys In-plane shear TEXTURE FORMABILITY EBSD
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Enhancement of Distributed Generation by Using Custom Power Device
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作者 Kishor V.Bhadane M.S.Ballal R.M.Moharil 《Journal of Electronic Science and Technology》 CAS CSCD 2015年第3期246-254,共9页
Wind energy (WE) has become immensely popular for distributed generation (DG). This case presents the monitoring, modeling, control, and analysis of the two-level three-phase WE based DG system where the electric ... Wind energy (WE) has become immensely popular for distributed generation (DG). This case presents the monitoring, modeling, control, and analysis of the two-level three-phase WE based DG system where the electric grid interfacing custom power device (CPD) is controlled to perform the smart exchanging of electric power as per the Indian grid code. WE is connected to DC link of CPD for the grid integration purpose. The CPD based distributed static compensator, i.e. the distributed static synchronous compensator (DSTATCOM), is utilized for injecting the wind power to the point of common coupling (PCC) and also acts against the reactive power demand. The novel indirect current control scheme of DSTATCOM regulates the power import and export between the WE and the electric grid system. It also acts as a compensator and performs both the key features simultaneously. Hence, the penetration of additional generated WE power to the grid is increased by 20% to 25%. The burden of reactive power compensation from grid is reduced by DSTATCOM. The modeling and simulation are done in MATLAB. The results are validated and verified. 展开更多
关键词 Custom power device distributed generation (DG) distributed static synchronous compensator (DSTATCOM) indirect current control scheme reactive power
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Study of various molar crown designs and their assessment
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作者 Rashmi Uddanwadiker 《Journal of Biomedical Science and Engineering》 2012年第11期629-633,共5页
Dental crowns are best utilized as a way to improve the cosmetics of a tooth appearance when the crown simultaneously serves other purposes also, such as restoring a tooth to its original shape or strengthening a toot... Dental crowns are best utilized as a way to improve the cosmetics of a tooth appearance when the crown simultaneously serves other purposes also, such as restoring a tooth to its original shape or strengthening a tooth. The study presents four different designs of molar crown depending upon the tooth loss. The finite element results obtained suggests that restored material which fills the treated cavity along with small portion of root canal can help in retaining the restored tooth and can allow larger deformations for stresses induced well within the limit. 展开更多
关键词 DENTAL CROWN THRESHOLDING BOOLEAN Operation SEGMENTATION
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Spatial Indexing of Buildings for Disaster Management
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作者 Rahul V. Ralegaonkar 《Journal of Civil Engineering and Architecture》 2011年第7期655-659,共5页
Natural disasters not only result in financial loss but also the human lives. The failure of the existing buildings is one of the primary concerns for the damage to human lives. In order to plan a disaster free city p... Natural disasters not only result in financial loss but also the human lives. The failure of the existing buildings is one of the primary concerns for the damage to human lives. In order to plan a disaster free city proper planning of the buildings & infrastructure along with the associated information of non-spatial attributes are needed. The present paper highlights the application of satellite imagery for feature extraction and storing the associated database in GIS environment which is useful for decision making in real time disaster management. The complete methodology is elaborated with the help of a case study for earthquake risk assessment of Maharashtra Industrial Development Corporation (MIDC), Akola, Maharashtra, India region. For the better and precise work 0.5 m. resolution imagery is utilized for extracting the buildings & other infrastructure features. The structural and non-structural details of the buildings are stored as back end for possible vulnerability assessment, suitable planning and preparedness against the hazard. The extracted building features in the planned area have been given suitable weightages for Vulnerability Indexing. Based on suggested indexing approach possible retrofitting measures from the developed database can be recommended for the existing buildings in the proposed location of research. The proposed approach can further be extended for the entire infrastructure of the nation where the centralized data can be made available with Emergency Operation Centre for further planning & preparedness to make the nation disaster free. 展开更多
关键词 Natural disaster non-spatial attributes satellite imagery DATABASE emergency operation centre.
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Anisotropic Bianchi Type Ⅰ Cosmological Models with Generalized Chaplygin Gas and Dynamical Gravitational and Cosmological Constants
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作者 S.Kotambkar G.P.Singh +1 位作者 R.Kelkar Binaya K.Bishi 《Communications in Theoretical Physics》 SCIE CAS CSCD 2017年第2期222-230,共9页
This paper deals with study of generalized Chaplygin gas model with dynamical gravitational and cosmological constants. In this paper a new set of exact solutions of Einstein field equations for spatially homogeneous ... This paper deals with study of generalized Chaplygin gas model with dynamical gravitational and cosmological constants. In this paper a new set of exact solutions of Einstein field equations for spatially homogeneous and anisotropic Bianchi type Ⅰ space-time have been obtained. The solutions of the Einstein's field equations are obtained by considering(i) the power law relation between Hubble parameter H and scale factor R and(ii) scale factor of the form R =-1/t + t^2, t > 1. The assumptions lead to constant and variable deceleration parameter respectively. The physical and dynamical behaviors of the models have been discussed with the help of graphical representations. Also we have discussed the stability and physical acceptability of solutions for solution type-Ⅰ and solution type-Ⅱ. 展开更多
关键词 Bianchi type space tine cosmological constant gravitational constant generalized Chaplygin gas
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Elastic and Inelastic Response of Structural Systems in Seismic Pounding
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作者 N. U. Mate S. V. Bakre +1 位作者 O. R. Jaiswal K. K. Sayyad 《Open Journal of Civil Engineering》 2016年第1期50-73,共24页
The present paper addresses the comparative study of three adjacent single-degree-of freedom structures for elastic and inelastic system with and without pounding under seismic excitations. For the gap between three a... The present paper addresses the comparative study of three adjacent single-degree-of freedom structures for elastic and inelastic system with and without pounding under seismic excitations. For the gap between three adjacent structures, the simulation is done by using linear spring element without damping. The entire numerical simulation is done in time domain by considering the inputs of four real ground motions. The results of the study show that the response of elastic system is much different to that of response of inelastic system in the absence and presence of pounding, especially in lighter or more flexible structures. Elastic structures show much severe pounding response than inelastic structures. Modeling of colliding structures behaving inelastically is really needed in order to obtain the accurate structural pounding involved response under seismic excitation. 展开更多
关键词 Seismic Pounding Gap Element MDOF Elastic and Inelastic Stick System Time History Analysis Spectral Acceleration Response
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南钢中厚板生产工艺数字化管理实践
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作者 王新平 吴俊平 《南钢科技与管理》 2022年第2期52-56,共5页
南钢以“创建国际一流受尊重的企业智慧生命体”为愿景,围绕“一切业务数字化,一切数字业务化”的总方针,大力推进两化深度融合及数字化、智能化工作。板材事业部以实现工艺管理数字化为重要抓手,以设备智能化、生产自动化、管理信息化... 南钢以“创建国际一流受尊重的企业智慧生命体”为愿景,围绕“一切业务数字化,一切数字业务化”的总方针,大力推进两化深度融合及数字化、智能化工作。板材事业部以实现工艺管理数字化为重要抓手,以设备智能化、生产自动化、管理信息化为目标,加快数字化改造和智能制造项目的实施,推动企业智能制造和数字化管理水平迈上新台阶,提升南钢板材的核心竞争力。 展开更多
关键词 中厚板 工艺 质量设计 数字化
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PD-1抑制剂联合治疗晚期肺鳞癌疗效及预后的相关独立因素分析
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作者 刘悦 袁玮蔚 +1 位作者 江庆 冉献贵 《医学信息》 2026年第4期113-117,共5页
目的探究PD-1抑制剂免疫联合治疗晚期肺鳞癌(LUSC)疗效及预后的相关独立因素。方法回顾性分析安徽医科大学附属阜阳人民医院2020年3月-2024年10月收治的使用PD-1抑制剂免疫联合治疗的104例晚期LUSC患者的资料,通过单因素和多因素分析影... 目的探究PD-1抑制剂免疫联合治疗晚期肺鳞癌(LUSC)疗效及预后的相关独立因素。方法回顾性分析安徽医科大学附属阜阳人民医院2020年3月-2024年10月收治的使用PD-1抑制剂免疫联合治疗的104例晚期LUSC患者的资料,通过单因素和多因素分析影响免疫联合治疗的疗效及预后的相关独立指标。结果治疗2个周期后,客观缓解率(ORR)为39.42%,疾病控制率(DCR)为92.31%。单因素分析结果显示,手术史、ECOG PS评分、治疗线数、维持治疗、NLR、SII、SIRI、LDH与PD-1抑制剂免疫联合治疗LUSC患者的PFS有关(P<0.05);而年龄、性别、吸烟史、多器官转移、肝转移、脑转移、放疗史、临床分期、PLR、LMR、PNI、PLT、FIB、ALP、CRP、HB均与患者的PFS无关(P>0.05)。多因素COX回归分析显示,维持治疗(HR=6.317,95%CI:3.397~11.748,P=0.000)、ECOG PS评分(HR=0.196,95%CI:0.051~0.740,P=0.017)和LDH(HR=2.997,95%CI:1.485~6.050,P=0.002)是影响PD-1抑制剂联合治疗LUSC患者PFS的独立相关因素。结论未维持治疗、高LDH、高ECOG PS评分与PD-1抑制剂联合治疗的晚期LUSC患者的预后欠佳有关,维持治疗、ECOG PS评分和LDH水平是影响疗效及预后的相关独立因素。 展开更多
关键词 肺鳞癌 PD-1抑制剂 独立因素
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Effect of blast inside tunnel on surrounding soil mass,tunnel lining,and superstructure for varying shapes of tunnels 被引量:3
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作者 M.D.Goel Shivani Verma +1 位作者 Jagriti Mandal Sandeep Panchal 《Underground Space》 SCIE EI 2021年第6期619-635,共17页
In this study,a finite element(FE)analysis of shallow tunnels exposed to a blast inside the tunnel,with soil as surrounding medium and a structure at ground level,was performed.The ConWep program,developed by the US A... In this study,a finite element(FE)analysis of shallow tunnels exposed to a blast inside the tunnel,with soil as surrounding medium and a structure at ground level,was performed.The ConWep program,developed by the US Army,was used to simulate blast loading using ABAQUS/Explicit■.Drucker-Prager(D-P)plasticity model,concrete damage plasticity(CDP),and Johnson-Cook(J-C)plasticity models were used to define the behavior of the soil,concrete,and reinforcement,respectively.FE analysis was carried out to compare the damages to the superstructure with variation in the cross-sectional shapes of the tunnel under internal blast loading.Three tunnel shapes(circular,rectangular,and horseshoe cross-sections)were considered in the FE analysis.An explosive of 100 kg TNT was located at the center of the cross-section of the tunnel.The response of the tunnel in terms of displacement and stress at critical locations was computed.The results showed that changes in the cross-section of the tunnel affect the stability of the tunnel,even when keeping all other factors constant.It was observed that the intensity of the stresses was the highest for a rectangular tunnel and lowest for a circular tunnel.Furthermore,it was also determined that the tunnel with a rectangular cross-section experienced the maximum displacement in the reinforced concrete(RC)lining compared with the horseshoe and circular tunnels.The displacement measured at critical structural members of the superstructure was found to be the highest for the tunnel with a rectangular cross-section and lowest for the tunnel with a circular cross-section. 展开更多
关键词 Blast loading Numerical simulation ConWep Framed superstructure FE analysis ABAQUS/Explicit■
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