Mongolia is an important country in the Economic Corridor of China-Mongolia-Russia, a deep understanding of the coupling relationship between urbanization and the eco-environment in Mongolia is meaningful to achieve g...Mongolia is an important country in the Economic Corridor of China-Mongolia-Russia, a deep understanding of the coupling relationship between urbanization and the eco-environment in Mongolia is meaningful to achieve green development of the Belt and Road. The entropy method and coupling coordination degree model were integrated to evaluate the coupling coordination degree between urbanization and the eco-environment in Mongolia during 2000-2016. The results showed that the coupling coordination degree between urbanization and the eco-environment in Mongolia was generally at the stage of seriously unbalanced development, and that the main contributor of the urbanization and the eco-environment subsystem were demographic urbanization and eco-environment endowment, respectively. The southern part of Mongolia central zone should be paid more attention due to the lower degree of coupling coordination between urbanization and the eco-environment. To promote the healthy urbanization development in Mongolia, six-layer eco-city establishing green development pattern is proposed to provide scientific support for Mongolia.展开更多
The global shift towards low-carbon energy storage has increased interest in sodium-ion batteries(SIBs)as a safer,cost-effective alternative to lithium-ion batteries.However,the commercial viability has been limited b...The global shift towards low-carbon energy storage has increased interest in sodium-ion batteries(SIBs)as a safer,cost-effective alternative to lithium-ion batteries.However,the commercial viability has been limited by compatibility issues between high-energy-density cathode materials,such as Na_(3)V_(2)(PO_(4))_(2)F_(3)(NVPF),and high-voltage electrolytes.Addressing the challenges,H-NaODFB(comprising 93.91%NaODFB and 5.85%NaBF_(4))electrolyte significantly improves the electrochemical performance and stability of NVPF cathodes,Na/NVPF half-cells using H-NaODFB electrolyte retained 92.4%capacity after 900cycles,while Na/Na symmetric cells demonstrated a cycle life exceeding 600 h at 0.5 mA cm^(-2).The superior performance is attributed to improved Na^(+)(de)intercalation reversibility,lower interfacial impedance(619.8 vs.10,650.0Ω),and faster reaction kinetics compared to NaODFB alone.Advanced time of flight-secondary ion mass spectrometry(TOF-SIMS),X-ray photoelectron spectroscopy(XPS)and aberration corrected transmission electron microscope(AC-TEM),combined with first-principles calculations,revealed that NaBF_(4)in the H-NaODFB electrolyte plays a critical role in forming a stable cathode electrolyte interphase(CEI).The CEI consists of an initial inorganic and organic layer,followed by a fluoroborate layer,and finally a stable organic-inorganic polymeric layer,enhancing electrode stability and preventing over-oxidation.These findings provide valuable insights for designing high-performance electrolytes for SIBs.展开更多
RNAi technologies have been exploited to control viruses,pests,oomycetes,and fungal phytopathogens that cause disasters inhost plants,including many agronomically significant crops.Double-stranded RNA(dsRNA)or small in...RNAi technologies have been exploited to control viruses,pests,oomycetes,and fungal phytopathogens that cause disasters inhost plants,including many agronomically significant crops.Double-stranded RNA(dsRNA)or small interfering RNA(siRNA)hasbeen applied as a trigger for trans-kingdom RNAi between hosts and fungi.However,it is unclear what process mediates RNAuptake by fungi.In this study,by using live-cell imaging,we determined that exogenously synthesized RNA or small RNA(sRNA)was indiscriminately absorbed into Verticillium dahliae,a notorious pathogenic fungus.Moreover,the application ofendocytic inhibitors or deletion of endocytic-related genes reduced RNA uptake efficiency,showing that RNA absorption byfungal cells occurs mainly through endocytosis.In addition,we found that the endocytosedfluorescence-labeled RNAs werepartly colocalized with endosome marker genes.Overall,our research concluded that exogenous RNA could be assimilated by V.dahliae through the endocytic pathway.Unraveling this cytological mechanism underlying trans-kingdom RNAi holds significantimportance,especially considering the fact that RNAi-based strategies targeting pathogenic fungi are increasingly prevalent in therealm of crop protection.展开更多
To investigate the geodynamic processes of Mesozoic large-scale mineralization in South China,we deployed a 350-km-long,wide-angle seismic reflection/refraction sounding profile between Yingshan in Hubei and Changshan...To investigate the geodynamic processes of Mesozoic large-scale mineralization in South China,we deployed a 350-km-long,wide-angle seismic reflection/refraction sounding profile between Yingshan in Hubei and Changshan in Zhejiang.This profile traverses the Cu-Au metallogenic belt in the middle and lower reaches of the Yangtze River(YMB),the Jiangnan W-polymetal metallogenic belt(JNMB),and the Qinhang Cu-polymetal metallogenic belt(QHMB).Our imaging results reveal various interesting velocity features along the profile.(1)The velocity structure is characterized by vertical layering and horizontal blocking;(2)the YMB is marked by high velocity and high V_(p)/V_(s) ratios in general with a significantly uplifted Moho interface and a thin crust of~31 km,and the lower crust contains high-velocity anomalies and has the characteristics of a crustmantle transition zone;(3)the JNMB is bounded by the Jiangnan fault and Jingdezhen-Huangshan fault and has low-velocity anomalies and low V_(p)/V_(s) ratios;and(4)the QHMB is characterized by high-velocity anomalies and high V_(p)/V_(s) ratios.The highvelocity anomalies in the YMB and QHMB represent relatively Cu-Au-rich mafic juvenile lower crust.The formation of this kind of crust is considered to be related to mantle-derived magma underplating or residues of Neoproterozoic oceanic crustal materials,and it also provided sources for large-scale Cu-Au mineralization in the Mesozoic.The JNMB has features similar to those of ancient crusts enriched in W-Sn,the partial melting of which played a leading role in the formation of the superlarge W deposits in this belt.Considering these results and other regional geological data,we propose that a large-scale oblique upwelling of the asthenosphere along the collisional belt of the Yangtze and Cathaysia blocks during the Mesozoic was the deep driving mechanism for the explosive mineralization of Cu,Au,and W in northeastern South China.The boundaries of the blocks or terrains and discontinuities of the lithosphere were the main channels for deep heat and magmas and therefore controlled the spatial distribution of the metallogenic belt.展开更多
We present a facile and versatile method for introducing various non-precious metal nanoparticles （NPs） in small nanotubes, such as single-walled carbon nanotubes （SWNTs）, including 3d-metals （V, Mn, Fe and Co）,...We present a facile and versatile method for introducing various non-precious metal nanoparticles （NPs） in small nanotubes, such as single-walled carbon nanotubes （SWNTs）, including 3d-metals （V, Mn, Fe and Co）, 4d-metals （Mo）, and 5d-metals （W）. This is realized by oxidizing encapsulated cycloalkene metal carbonyl complexes below their sublimation temperatures. This novel technique is significant because it avoids the diffusion and deposition of metal species on the outer walls of nanotubes, which has been challenging to achieve using the conventional filling methods. High-resolution transmission electron microscopy （HRTEM）, high angle annular dark field scanning transmission electron microscopy （HAADF-STEM）, energy-dispersive X-ray spectroscopy （EDX）, Raman, and X-ray photoelectron spectroscopy （XPS） analyses revealed high filling efficiencies （〉 95% SWNTs filled with metal NPs）. This method also provides a unique approach to fabricate highly dispersed and uniform SWNT-metal nanoparficle encapsulates with lower valence states, which are often not stable in the bulk.展开更多
An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diami...An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diamines were compatible with this method,generating both the recovered staring materials and the amination products with high enantioselectivities(with s-factor up to 218).Notably,this method is amenable to the kinetic resolution of 1,2-diamines bearingα-tertiary amine moieties,which represents the first KR of this type of 1,2-diamines.Facile removal of the introduced hydrazine group and oxidative cleavage of the N-aryl group to release the free primary amine demonstrate the value of this method.展开更多
Knowledge of asymmetric catalytic reaction mechanism is very important for rational design and synthesis of new chiral catalysts or catalytic systems with high catalytic activity and stereoselectivity.The studies of n...Knowledge of asymmetric catalytic reaction mechanism is very important for rational design and synthesis of new chiral catalysts or catalytic systems with high catalytic activity and stereoselectivity.The studies of nonlinear effect have attracted wide attentions as a simple and practical mechanistic tool to probe complex asymmetric catalytic reactions.展开更多
Dear Editor,Cardiovascular diseases(CVDs)are the leading cause of death world-wide.Thus,diagnosing and treating CVD remains at the forefront for clinicians while identifying targetable disease mechanisms in preclinica...Dear Editor,Cardiovascular diseases(CVDs)are the leading cause of death world-wide.Thus,diagnosing and treating CVD remains at the forefront for clinicians while identifying targetable disease mechanisms in preclinical models are focus areas for researchers and drug developers(Cai et al.,2022a).The polymorphic protein apolipoprotein E(APOE),central to lipid transport and metabolism,is well-recognized for the role of its isoforms as important predictors for human cardiovascular disorders and neurodegenerative diseases(Tudorache et al.,2017).Plasma APOE is generated primarily from liver hepatocytes,accounting for around 75%of the APOE production from the whole body(Getz and Reardon,2009),and plays important functional roles in monocytes/macrophages,adipocytes,and the central nervous system(Kockx et al.,2018).However,despite the fact that APOE is widely expressed in different mammalian cells,studies on the functional roles of APOE mostly focus on its extracellular secreted form,and the specific effects of APOE,particularly intracellular form in cell types closely related to human cardiovascular diseases are therefore still poorly understood.展开更多
The engineering design and construction of active interfaces represents a promising approach amidst numerous initiatives aimed at augmenting catalytic activity.Herein,we present a novel approach to incorporate interco...The engineering design and construction of active interfaces represents a promising approach amidst numerous initiatives aimed at augmenting catalytic activity.Herein,we present a novel approach to incorporate interconnected pores within bulk single crystals for the synthesis of macroscopic porous single-crystalline rutile titanium oxide(R-TiO_(2)).The porous single crystal(PSC)R-TiO_(2) couples a nanocrystalline framework as the solid phase with pores as the fluid phase within its structure,providing unique advantages in localized structure construction and in the field of catalysis.We successfully construct well-defined Ni cluster/TiO_(2) active interfaces by directly confining Ni clusters on the continuous lattice surface of PSC R-TiO_(2).We confirm that the lattice oxygen connected to the Ni clusters exhibits exceptional activation capability at temperatures close to room temperature compared to the pure phase PSC R-TiO_(2) monoliths.The PSC Ni/TiO_(2) catalyst demonstrates complete CO oxidation and stable catalytic performance during continuous operation in air at~80℃ for 200 h.展开更多
CD146 is a newly identified endothelial biomarker that has been implicated in angiogenesis. Though in vitro angio- genic function of CD146 has been extensively reported, in vivo evidence is still lacking. To address t...CD146 is a newly identified endothelial biomarker that has been implicated in angiogenesis. Though in vitro angio- genic function of CD146 has been extensively reported, in vivo evidence is still lacking. To address this issue, we generated endothelial-specific CD146 knockout （CD146 EC-Ko） mice using the Tg（Tek-cre） system. Surprisingly, these mice did not exhibit any apparent morphological defects in the development of normal retinal vasculature. To evaluate the role of CD146 in pathological angiogenesis, a xenograft tumor model was used. We found that both tumor volume and vascular density were significantly lower in CD146Ec-KO mice when compared to WT littermates. Additionally, the ability for sprouting, migration and tube formation in response to VEGF treatment was impaired in endothelial cells （ECs）of CD146Ec-Ko mice. Mechanistic studies further confirmed that VEGF- induced VEGFR-2 phosphorylation and AKT/p38 MAPKs/ NF-KB activation were inhibited in these CD146-null ECs, which might present the underlying cause for the observed inhibition of tumor angiogenesis in CD146Ec-Ko mice. These results suggest that CD146 plays a redundant role in physiological angiogenic processes, but becomes essential during pathological angiogenesis as observed in tumorigenesis.展开更多
Impactstatement Earth's lower near space of 20-40 km above sea level with polyextreme conditions serves as a unique Mars analog for astrobiological research to investigate the limits of life on Earth and planetary...Impactstatement Earth's lower near space of 20-40 km above sea level with polyextreme conditions serves as a unique Mars analog for astrobiological research to investigate the limits of life on Earth and planetary protection considerations for Mars exploration.In this study,we exposed Mars-like desert regolith to near space at a float altitude of~35 km and isolated four bacterial strains after exposure.展开更多
基金Under the auspices of the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA20030203,XDA20030202)National Social Science Found of China(No.17VDL016)National Key Research and Development Program of China(No.2017FY101304)
文摘Mongolia is an important country in the Economic Corridor of China-Mongolia-Russia, a deep understanding of the coupling relationship between urbanization and the eco-environment in Mongolia is meaningful to achieve green development of the Belt and Road. The entropy method and coupling coordination degree model were integrated to evaluate the coupling coordination degree between urbanization and the eco-environment in Mongolia during 2000-2016. The results showed that the coupling coordination degree between urbanization and the eco-environment in Mongolia was generally at the stage of seriously unbalanced development, and that the main contributor of the urbanization and the eco-environment subsystem were demographic urbanization and eco-environment endowment, respectively. The southern part of Mongolia central zone should be paid more attention due to the lower degree of coupling coordination between urbanization and the eco-environment. To promote the healthy urbanization development in Mongolia, six-layer eco-city establishing green development pattern is proposed to provide scientific support for Mongolia.
基金financially supported by the Cultivation and Construction of Ten National Science and Technology Innovation Platforms in Qinghai Province(2024-ZJ-J03)Xining Major Science and Technology Innovation Platform Capacity Building Project(2024-Z1)+1 种基金funding from Young Scholars of Western China,Chinese Academy of Sciences(E110HX0501)Qinghai Province Youth Science and Technology Talent Support Project(2022QHSKXRCTJ06)。
文摘The global shift towards low-carbon energy storage has increased interest in sodium-ion batteries(SIBs)as a safer,cost-effective alternative to lithium-ion batteries.However,the commercial viability has been limited by compatibility issues between high-energy-density cathode materials,such as Na_(3)V_(2)(PO_(4))_(2)F_(3)(NVPF),and high-voltage electrolytes.Addressing the challenges,H-NaODFB(comprising 93.91%NaODFB and 5.85%NaBF_(4))electrolyte significantly improves the electrochemical performance and stability of NVPF cathodes,Na/NVPF half-cells using H-NaODFB electrolyte retained 92.4%capacity after 900cycles,while Na/Na symmetric cells demonstrated a cycle life exceeding 600 h at 0.5 mA cm^(-2).The superior performance is attributed to improved Na^(+)(de)intercalation reversibility,lower interfacial impedance(619.8 vs.10,650.0Ω),and faster reaction kinetics compared to NaODFB alone.Advanced time of flight-secondary ion mass spectrometry(TOF-SIMS),X-ray photoelectron spectroscopy(XPS)and aberration corrected transmission electron microscope(AC-TEM),combined with first-principles calculations,revealed that NaBF_(4)in the H-NaODFB electrolyte plays a critical role in forming a stable cathode electrolyte interphase(CEI).The CEI consists of an initial inorganic and organic layer,followed by a fluoroborate layer,and finally a stable organic-inorganic polymeric layer,enhancing electrode stability and preventing over-oxidation.These findings provide valuable insights for designing high-performance electrolytes for SIBs.
基金supported by the National Key R&D Programof China(2022YFD1400800)the National Natural ScienceFoundation of China grant(No.32270204)BiologicalBreeding of Early Maturing and Disease Resistant CottonVarieties(Project No.2023ZD04041).
文摘RNAi technologies have been exploited to control viruses,pests,oomycetes,and fungal phytopathogens that cause disasters inhost plants,including many agronomically significant crops.Double-stranded RNA(dsRNA)or small interfering RNA(siRNA)hasbeen applied as a trigger for trans-kingdom RNAi between hosts and fungi.However,it is unclear what process mediates RNAuptake by fungi.In this study,by using live-cell imaging,we determined that exogenously synthesized RNA or small RNA(sRNA)was indiscriminately absorbed into Verticillium dahliae,a notorious pathogenic fungus.Moreover,the application ofendocytic inhibitors or deletion of endocytic-related genes reduced RNA uptake efficiency,showing that RNA absorption byfungal cells occurs mainly through endocytosis.In addition,we found that the endocytosedfluorescence-labeled RNAs werepartly colocalized with endosome marker genes.Overall,our research concluded that exogenous RNA could be assimilated by V.dahliae through the endocytic pathway.Unraveling this cytological mechanism underlying trans-kingdom RNAi holds significantimportance,especially considering the fact that RNAi-based strategies targeting pathogenic fungi are increasingly prevalent in therealm of crop protection.
基金supported by the National Key R&D Program of China(Grant Nos.2019YFA0708602,2019YFA0708603,and 2016YFC0600201)the National Natural Science Foundation of China(Grant Nos.42130807,42074099)the China Geological Survey(Grant No.1212011220243)。
文摘To investigate the geodynamic processes of Mesozoic large-scale mineralization in South China,we deployed a 350-km-long,wide-angle seismic reflection/refraction sounding profile between Yingshan in Hubei and Changshan in Zhejiang.This profile traverses the Cu-Au metallogenic belt in the middle and lower reaches of the Yangtze River(YMB),the Jiangnan W-polymetal metallogenic belt(JNMB),and the Qinhang Cu-polymetal metallogenic belt(QHMB).Our imaging results reveal various interesting velocity features along the profile.(1)The velocity structure is characterized by vertical layering and horizontal blocking;(2)the YMB is marked by high velocity and high V_(p)/V_(s) ratios in general with a significantly uplifted Moho interface and a thin crust of~31 km,and the lower crust contains high-velocity anomalies and has the characteristics of a crustmantle transition zone;(3)the JNMB is bounded by the Jiangnan fault and Jingdezhen-Huangshan fault and has low-velocity anomalies and low V_(p)/V_(s) ratios;and(4)the QHMB is characterized by high-velocity anomalies and high V_(p)/V_(s) ratios.The highvelocity anomalies in the YMB and QHMB represent relatively Cu-Au-rich mafic juvenile lower crust.The formation of this kind of crust is considered to be related to mantle-derived magma underplating or residues of Neoproterozoic oceanic crustal materials,and it also provided sources for large-scale Cu-Au mineralization in the Mesozoic.The JNMB has features similar to those of ancient crusts enriched in W-Sn,the partial melting of which played a leading role in the formation of the superlarge W deposits in this belt.Considering these results and other regional geological data,we propose that a large-scale oblique upwelling of the asthenosphere along the collisional belt of the Yangtze and Cathaysia blocks during the Mesozoic was the deep driving mechanism for the explosive mineralization of Cu,Au,and W in northeastern South China.The boundaries of the blocks or terrains and discontinuities of the lithosphere were the main channels for deep heat and magmas and therefore controlled the spatial distribution of the metallogenic belt.
文摘We present a facile and versatile method for introducing various non-precious metal nanoparticles （NPs） in small nanotubes, such as single-walled carbon nanotubes （SWNTs）, including 3d-metals （V, Mn, Fe and Co）, 4d-metals （Mo）, and 5d-metals （W）. This is realized by oxidizing encapsulated cycloalkene metal carbonyl complexes below their sublimation temperatures. This novel technique is significant because it avoids the diffusion and deposition of metal species on the outer walls of nanotubes, which has been challenging to achieve using the conventional filling methods. High-resolution transmission electron microscopy （HRTEM）, high angle annular dark field scanning transmission electron microscopy （HAADF-STEM）, energy-dispersive X-ray spectroscopy （EDX）, Raman, and X-ray photoelectron spectroscopy （XPS） analyses revealed high filling efficiencies （〉 95% SWNTs filled with metal NPs）. This method also provides a unique approach to fabricate highly dispersed and uniform SWNT-metal nanoparficle encapsulates with lower valence states, which are often not stable in the bulk.
基金NSFC(Grant No.22171186) and ShanghaiTech University start-up funding for financial supportthe support from Analytical Instrumentation Center(contract no.SPST-AIC10112914),SPST。
文摘An efficient kinetic resolution(KR)protocol for 1,2-diamines has been developed through asymmetric electrophilic aminations of anilines enabled by chiral phosphoric acid catalysis.A wide array of substituted 1,2-diamines were compatible with this method,generating both the recovered staring materials and the amination products with high enantioselectivities(with s-factor up to 218).Notably,this method is amenable to the kinetic resolution of 1,2-diamines bearingα-tertiary amine moieties,which represents the first KR of this type of 1,2-diamines.Facile removal of the introduced hydrazine group and oxidative cleavage of the N-aryl group to release the free primary amine demonstrate the value of this method.
基金the National Key R&D Program of China(Grant No.2017YFA0700103)the NSFC(Grant Nos.22225107,21922112,21871258)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB20000000).
文摘Knowledge of asymmetric catalytic reaction mechanism is very important for rational design and synthesis of new chiral catalysts or catalytic systems with high catalytic activity and stereoselectivity.The studies of nonlinear effect have attracted wide attentions as a simple and practical mechanistic tool to probe complex asymmetric catalytic reactions.
基金supported by the National Key Research and Development Program of China(nos.2020YFA0804000,2022YFA1103700,2020YFA0112200,2021YFF1201005,2022YFA1103800,the STI2030-Major Projects-2021ZD0202400)the National Natural Science Foundation of China(nos.81921006,82125011,92149301,92168201,91949209,92049304,92049116,32121001,82192863,82122024,82071588,32000500,82271600,32100937)+7 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(no.XDA16000000)the Program of the Beijing Natural Science Foundation(no.Z190019)CAS Project for Young Scientists in Basic Research(nos.YSBR-076,YSBR-012)The Pilot Project for Public Welfare Development and Reform of Beijing-affliated Medical Research Institutes(no.11000022T000000461062)Youth Innovation Promotion Association of CAS(nos.E1CAZW0401,2022083)Young Elite Scientists Sponsorship Program by CAST(nos.YESS20200012,YESS20210002)the Informatization Plan of Chinese Academy of Sciences(nos.CAS-WX2021SF-0301,CAS-WX2022SDC-XK14,CASWx2021SF-0101)the Tencent Foundation(no.2021-1045).
文摘Dear Editor,Cardiovascular diseases(CVDs)are the leading cause of death world-wide.Thus,diagnosing and treating CVD remains at the forefront for clinicians while identifying targetable disease mechanisms in preclinical models are focus areas for researchers and drug developers(Cai et al.,2022a).The polymorphic protein apolipoprotein E(APOE),central to lipid transport and metabolism,is well-recognized for the role of its isoforms as important predictors for human cardiovascular disorders and neurodegenerative diseases(Tudorache et al.,2017).Plasma APOE is generated primarily from liver hepatocytes,accounting for around 75%of the APOE production from the whole body(Getz and Reardon,2009),and plays important functional roles in monocytes/macrophages,adipocytes,and the central nervous system(Kockx et al.,2018).However,despite the fact that APOE is widely expressed in different mammalian cells,studies on the functional roles of APOE mostly focus on its extracellular secreted form,and the specific effects of APOE,particularly intracellular form in cell types closely related to human cardiovascular diseases are therefore still poorly understood.
基金the funding support provided by the Natural Science Foundation of China(22325506)the Shanghai Science and Technology Innovation Action Plan(24TS1414400)+4 种基金the Shanghai Jiao Tong University 2030 Initiative(2030B24)Industry support(24YW2024)from Shanghai Nuclear Engineering Research and Design Institute Co.Ltd.the China Postdoctoral Science Foundation(2023TQ0354 and 2023M743497)the Postdoctoral Fellowship Program of CPSF(GZB20230759)the Fujian STS plan supporting project(2022T3022,2023T3050,and 2023T3051)for this work.
文摘The engineering design and construction of active interfaces represents a promising approach amidst numerous initiatives aimed at augmenting catalytic activity.Herein,we present a novel approach to incorporate interconnected pores within bulk single crystals for the synthesis of macroscopic porous single-crystalline rutile titanium oxide(R-TiO_(2)).The porous single crystal(PSC)R-TiO_(2) couples a nanocrystalline framework as the solid phase with pores as the fluid phase within its structure,providing unique advantages in localized structure construction and in the field of catalysis.We successfully construct well-defined Ni cluster/TiO_(2) active interfaces by directly confining Ni clusters on the continuous lattice surface of PSC R-TiO_(2).We confirm that the lattice oxygen connected to the Ni clusters exhibits exceptional activation capability at temperatures close to room temperature compared to the pure phase PSC R-TiO_(2) monoliths.The PSC Ni/TiO_(2) catalyst demonstrates complete CO oxidation and stable catalytic performance during continuous operation in air at~80℃ for 200 h.
文摘CD146 is a newly identified endothelial biomarker that has been implicated in angiogenesis. Though in vitro angio- genic function of CD146 has been extensively reported, in vivo evidence is still lacking. To address this issue, we generated endothelial-specific CD146 knockout （CD146 EC-Ko） mice using the Tg（Tek-cre） system. Surprisingly, these mice did not exhibit any apparent morphological defects in the development of normal retinal vasculature. To evaluate the role of CD146 in pathological angiogenesis, a xenograft tumor model was used. We found that both tumor volume and vascular density were significantly lower in CD146Ec-KO mice when compared to WT littermates. Additionally, the ability for sprouting, migration and tube formation in response to VEGF treatment was impaired in endothelial cells （ECs）of CD146Ec-Ko mice. Mechanistic studies further confirmed that VEGF- induced VEGFR-2 phosphorylation and AKT/p38 MAPKs/ NF-KB activation were inhibited in these CD146-null ECs, which might present the underlying cause for the observed inhibition of tumor angiogenesis in CD146Ec-Ko mice. These results suggest that CD146 plays a redundant role in physiological angiogenic processes, but becomes essential during pathological angiogenesis as observed in tumorigenesis.
基金This study was supported by the National Natural Science Foundation of China(NSFC)grant T2225011the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA17010501).
文摘Impactstatement Earth's lower near space of 20-40 km above sea level with polyextreme conditions serves as a unique Mars analog for astrobiological research to investigate the limits of life on Earth and planetary protection considerations for Mars exploration.In this study,we exposed Mars-like desert regolith to near space at a float altitude of~35 km and isolated four bacterial strains after exposure.
