Osteoradionecrosis of the temporal bone(ORN-TB)is usually controlled with conservative measures.However,a temporal bone resection may be required in unresponsive cases.The reconstruction of the resulting defects may b...Osteoradionecrosis of the temporal bone(ORN-TB)is usually controlled with conservative measures.However,a temporal bone resection may be required in unresponsive cases.The reconstruction of the resulting defects may be challenging because of the radiation damage to regional tissues.As a result,distant free flaps may be an optimal choice.For instance,the gracilis muscular free flap(GMFF)has consistent vascular anatomy and can be used to reconstruct small defects.We report three cases of uncontrolled ORN-TB requiring an extensive temporal bone resection followed by vascularized obliteration with a GMFF.The patients reported complete control of the main otologic symptoms(otorrhea,otalgia,and aural fullness)and optimal functional and aesthetic outcomes.Finally,the patients reported significant improvement in quality of life despite early postoperative complications.To our knowledge,the GMFF had not been used to obliterate temporal bone defects in patients with ORN-TB.展开更多
The online version of the original article can be found at:https://www.sciopen.com/article/10.26599/JOTO.2025.9540018 Erratum to Journal of Otology,2025,20(2):123-126.https://doi.org/10.26599/JOTO.2025.9540018 The sur...The online version of the original article can be found at:https://www.sciopen.com/article/10.26599/JOTO.2025.9540018 Erratum to Journal of Otology,2025,20(2):123-126.https://doi.org/10.26599/JOTO.2025.9540018 The surnames and given names of these authors are reversed:Saro-Buendía Miguel,Andresen-Lorca Belén,Pérez-García Alberto,Llópez Carratala Nacho,Carreres Polo Joan,Armengot Carceller Miguel,Perolada Valmaña Jose María.It should be Miguel Saro-Buendía,Belén Andresen-Lorca,Alberto Pérez-García,Nacho Llópez Carratala,Joan Carreres Polo,Miguel Armengot Carceller,Jose María Perolada Valmaña.展开更多
BACKGROUND Childhood trauma and parental socialization have been postulated as environmental factors of at-risk mental state(ARMS).Parental socialization is the process through which parents shape children’s self-reg...BACKGROUND Childhood trauma and parental socialization have been postulated as environmental factors of at-risk mental state(ARMS).Parental socialization is the process through which parents shape children’s self-regulation by providing guidance and protection.Although the impact of trauma on ARMS has been theorized,its clinical implications have not yet been fully clarified in adolescence,nor have explanatory models of parenting styles been established.AIM To investigate the role of traumatic experiences in the appearance of ARMS in the general adolescent population,considering the influence of parental socialization.METHODS A cross-sectional study of 697 adolescents aged 11-15 years was conducted,during which several questionnaires assessing childhood trauma,psychotic symptoms,and parenting styles were administered.The sample was divided into control,low-risk,medium-risk,and high-risk groups.RESULTS Some 2.8%(n=19)of the adolescents presented ARMS and the presence of childhood trauma was associated with an increased risk of ARMS.Furthermore,the presence of abuse was greater in the high-risk and low-risk groups compared to controls.Regarding parental socialization,it was determined that a family socialization style based on greater affection–communication decreased the probability of ARMS.Finally,using PROCESS model 1(regressionbased path analysis that uses ordinary least squares regression),results suggested that low levels of affection and communication may mediate the relationship between childhood trauma and ARMS in adolescents.CONCLUSION These results highlight the importance of the early detection of trauma in preventing ARMS,without forgetting the importance of socialization styles.展开更多
This review summarizes the evidence about telemonitoring in patients with inflammatory bowel disease(IBD). To give an overview of the advances performed, as well as the enablers and barriers which favoured/hindered te...This review summarizes the evidence about telemonitoring in patients with inflammatory bowel disease(IBD). To give an overview of the advances performed, as well as the enablers and barriers which favoured/hindered telemonitoring implementation. We performed a literature search in Pub Med, EMBASE, MEDLINE, Cochrane Database, Web of Science and Conference Proceedings. Titles and abstracts published up to September 2022 were screened for a set of inclusion criteria: telemonitoring intervention, IBD as the main disease, and a primary study performed. Ninety-seven reports were selected for full review. Finally, 20 were included for data extraction and critical appraisal. Most studies used telemonitoring combined with tele-education, and programs evolved from home telemanagement systems towards web portals through m Health applications. Web systems demonstrated patients’ acceptance, improvement in quality of life, disease activity and knowledge, with a good cost-effectiveness profile in the short-term. Initially, telemonitoring was almost restricted to ulcerative colitis, but new patient reported outcome measures, home-based tests and mobile devices favoured its expansion to different patients’ categories. However, technological and knowledge advances led to legal, ethical, economical and logistic issues. Standardization of remote healthcare is necessary, to improve the interoperability of systems as well as to address liability concerns and users’ preferences. Telemonitoring IBD is well accepted and improves clinical outcomes at a lower cost in the short-term. Funders, policymakers, providers, and patients need to align their interests to overcome the emerging barriers for its full implementation.展开更多
The hybrid boundary node method （HBNM） is a promising method for solving boundary value problems with the hybrid displacement variational formulation and shape functions from the moving least squares（MLS） approxim...The hybrid boundary node method （HBNM） is a promising method for solving boundary value problems with the hybrid displacement variational formulation and shape functions from the moving least squares（MLS） approximation. The main idea is to reduce the dimensionality of the former and keep the meshless advantage of the latter. Following its application in solving potential problems, it is further developed and numerically implemented for 2D solids in this paper. The rigid movement method is employed to solve the hyper-singular integrations. Numerical examples for some 2D solids have been given to show the characteristics. The computation results obtained by the present method are in excellent agreement with the analytical solution. The parameters that influence the performance of this method are studied through numerical examples.展开更多
AIM： To determine the presence of symptomatic accommodative and non-strabismic binocular dysfunctions （A.sBD） in a non-presbyopic population of video display unit （VDU） users with flat-panel displays. METHODS： ...AIM： To determine the presence of symptomatic accommodative and non-strabismic binocular dysfunctions （A.sBD） in a non-presbyopic population of video display unit （VDU） users with flat-panel displays. METHODS： One hundred and one VDU users, aged between 20 to 34y, initially participated in the study. This study excluded contact-lens wearers and subjects who had undergone refractive surgery or had any systemic or ocular disease. First, subjects were asked about the type and nature of eye symptoms they experienced during VDU use. Then, a thorough eye examination excluded those subjects with a significant uncorrected refractive error or other problem, such as ocular motility disorders, vertical deviation, strabismus and eye diseases. Finally, the remaining participants underwent an exhaustive assessment of their accommodative and binocular vision status. RESULTS： Eighty-nine VDU users （46 females and 43 males） were included in this study. They used flat-panel displays for an average of 5±1.9h a day. Twenty subjects presented A.sBD （22.5%）. Convergence excess was the most frequent non-strabismic binocular dysfunction （9 subjects）, followed by fusional vergence dysfunction （3 subjects） and convergence insufficiency （2 subjects）. Within the accommodative dysfunctions, accommodative excess was the most common （4 subjects）, followed by accommodative insufficiency （2 subjects）. Moderate to severe eye symptoms were found in 13 subjects with ANSBD. CONCLUSION： Significant eye symptoms in VDU users with accommodative and/or non-strabismic binocular dysfunctions often occur and should not be underestimated; therefore, an appropriate evaluation of accommodative and binocular vision status is more important for this population,展开更多
The aim of this paper is to determine the role of enzymatic vitrectomy performed by intravitreal injection of autologous plasmin enzyme(APE)in the management of diabetic retinopathy and diabetic macular edema(DME).Dia...The aim of this paper is to determine the role of enzymatic vitrectomy performed by intravitreal injection of autologous plasmin enzyme(APE)in the management of diabetic retinopathy and diabetic macular edema(DME).Diabetic patients with proliferative diabetic retinopathy or DME and evident posterior hyaloid adherence to the retinal surface were included.All cases were treated with an initial intravitreal injection of APE and reevaluated one month later,measuring changes in best-corrected visual acuity(BCVA),macular thickness and the status of the posterior hyaloid.A second APE injection was performed in cases with no evident posterior vitreous detachment(PVD)after the initial treatment.Sixty-three eyes were included in the present review.A complete PVD appeared in 38%of cases(24 eyes)after one injection of plasmin and the total increased to 51%(32 eyes)after the second injection,separated at least by one month.The central macular thickness improved in all cases(100%)and BCVA in89%.Finally,in 50%of eyes with proliferative diabetic retinopathy,a high reduction of new vessels regression was observed.Enzymatic vitrectomy could be considered a good therapeutic alternative in diabetic retinopathy and macular edema.展开更多
Driving style,traffic and weather conditions have a significant impact on vehicle fuel consumption and in particular,the road freight traffic significantly contributes to the CO2 increase in atmosphere.This paper prop...Driving style,traffic and weather conditions have a significant impact on vehicle fuel consumption and in particular,the road freight traffic significantly contributes to the CO2 increase in atmosphere.This paper proposes an Eco-Route Planner devoted to determine and communicate to the drivers of Heavy-Duty Vehicles(HDVs)the eco-route that guarantees the minimum fuel consumption by respecting the travel time established by the freight companies.The proposed eco-route is the optimal route from origin to destination and includes the optimized speed and gear profiles.To this aim,the Cloud Computing System architecture is composed of two main components:the Data Management System that collects,fuses and integrates the raw external sources data and the Cloud Optimizer that builds the route network,selects the eco-route and determines the optimal speed and gear profiles.Finally,a real case study is discussed by showing the benefit of the proposed Eco-Route planner.展开更多
Gastroesophageal reflux disease (GERD) is a chronic digestive disorder that affects a growing number of people in the world and is one of the most common gastric complaints that prompts an individual to consult a doct...Gastroesophageal reflux disease (GERD) is a chronic digestive disorder that affects a growing number of people in the world and is one of the most common gastric complaints that prompts an individual to consult a doctor. Heartburn and regurgitation are the most predominant esophageal symptoms of GERD, but patients with the disease may also have extra esophageal symptoms, such as epigastric pain, bronchospasm, and chronic cough. All of these symptoms may compromise health-related quality of life with modification of eating habits and sleep pattern that have a great impact on the normal daily. Furthermore, GERD is a multifactorial disease that can be complicated and difficult to treat. Mechanical, chemical, physiopathologic, and functional factors that predispose patients to the disease are still under investigation. A simple treatment plan for manual therapists is presented based on current evidence-based literature;it is designed to reduce symptoms of GERD through somatovisceral approach and the nutrition.展开更多
The size evolution of gold nanoparticles synthesized using tannic acid with initial gold chloride concentrations ranging from 0.2 - 2 mM at various tannic acid to chloroauric acid molar ratios (ranging from 2:1 to 12:...The size evolution of gold nanoparticles synthesized using tannic acid with initial gold chloride concentrations ranging from 0.2 - 2 mM at various tannic acid to chloroauric acid molar ratios (ranging from 2:1 to 12:1) has been analysed. Dynamic light scattering spectroscopic and tramission electron microscopic analyses were performed to assess the size of formed gold nanoparticles. Two different patterns of nanoparticle size evolution were obtained;the size evolution trend below 1 mM chloroauric acid concentration was found to be different from the one obtained at gold chloride concentrations higher than or equal to 1 mM. In case of sizes obtained for less than 1 mM gold chloride concentration, a general decrease in particle size was observed with increase in gold salt concentration. On the contrary, for the particles synthesised using chloroauric acid concentrations higher than or equal to 1 mM, with increase in gold salt concentration, a general increase in nanoparticle diameter was seen. For the molarities 0.2 and 0.5 mM, with increase in tannic acid/ chloroauric acid ratios, first the size decreases and then increases and finally reaches saturation. Particles formed at molarities greater than equal to 1 mM do not exhibit plateaux in their size rather initially decrease and then increase in response to increasing tannic acid/chloroauric acid ratios except for 2 mM concentration at which a small saturation is observed. The findings enumerate that higher gold chloride concentrations leave a significant impact on the sizes of gold nanaparticles obtained using tannic acid as a reducing agent of chloroauric acid solution.展开更多
Background:Hepatectomy in patients with large tumor load may result in postoperative liver failure and associated complications due to excessive liver parenchyma removal.Conventional two-stage hepatectomy(TSH)and asso...Background:Hepatectomy in patients with large tumor load may result in postoperative liver failure and associated complications due to excessive liver parenchyma removal.Conventional two-stage hepatectomy(TSH)and associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique are possible solutions to this problem.Colorectal liver metastases(CRLM)is the most frequent indication,and there is a need to assess outcomes for both techniques to improve surgical and long-term oncological outcomes in these patients.Methods:A single-center retrospective study was designed to compare TSH with ALPPS in patients with initially unresectable bilateral liver tumors between January 2005 and January 2020.ALPPS was performed from January 2012 onwards as the technique of choice.Long-term overall survival(OS)and disease-free survival(DFS)were evaluated as primary outcome in CRLM patients.Postoperative morbidity,mortality and liver growth in all patients were also evaluated.Results:A total of 38 staged hepatectomies were performed:17 TSH and 21 ALPPS.Complete resection rate was 76.5%(n=13)in the TSH group and 85.7%(n=18)in the ALPPS group(P=0.426).Overall major morbidity(Clavien-Dindo≥3 a)(stage 1+stage 2)was 41.2%(n=7)in TSH and 33.3%(n=7)in ALPPS patients(P=0.389),and perioperative 90-day mortalities were 11.8%(n=2)vs.19.0%(n=4)in each group,respectively(P=0.654).Intention-to-treat OS rates at 1 and 5 years in CRLM patients for TSH(n=15)were 80%and 33%,and for ALPPS(n=17)76%and 35%,respectively.DFS rates at 1 and 5 years were 36%and 27%in the TSH group vs.33%and 27%in the ALPPS group,respectively.Conclusions:ALPPS is an effective alternative to TSH in bilateral affecting liver tumors,allowing higher resection rate,but patients must be carefully selected.In CRLM patients similar long-term OS and DFS can be achieved with both techniques.展开更多
Dear Editor, Polyorchidism refers to the presence of more than two testicles. Blasius described it for the first time in 1670 as an incidental finding in an autopsy, while Lane was the one who performed the first his...Dear Editor, Polyorchidism refers to the presence of more than two testicles. Blasius described it for the first time in 1670 as an incidental finding in an autopsy, while Lane was the one who performed the first histological description of a supernumerary testis in 1895.1,2 Before imaging diagnosis techniques, this condition could only be verified under surgical exploration. Nowadays, current imaging techniques have increased the number of diagnosis of this anatomical variation. On the other hand, there is still a certain group of physicians who use histological analysis as the unioue way to diagnosis.展开更多
Objective: Extracorporeal shockwave lithotripsy (SWL) currently plays an important role in the treatment of urinary tract lithiasis. The purpose of this article was to describe new concepts and procedural strategies t...Objective: Extracorporeal shockwave lithotripsy (SWL) currently plays an important role in the treatment of urinary tract lithiasis. The purpose of this article was to describe new concepts and procedural strategies that would improve results using SWL as a treatment for urolithiasis, thereby achieving better clinical practice.Methods: A systematic review process was carried in PubMed/PMC from January 2003 to March 2023. A narrative synthesis of the most important aspects has been made.Results: The important recommendations for the adequate selection of the candidate patient for treatment with SWL are summarized, as well as the new strategies for a better application of the technique. Aspects about intraoperative position, stone localization and monitoring, analgesic control, machine and energy settings, and measures aiming at reduced risk of complications are described.Conclusion: To achieve the therapeutic goal of efficient stone disintegration without increasing the risk of complications, it is necessary to make an adequate selection of patients and to pay special attention to several important factors in the application of treatment. Technological development in later generation devices will help to improve current SWL results.展开更多
Existence of linear polarization,formed by anisotropic scattering in the photosphere,has been demonstrated observationally as well as theoretically and is called second solar spectrum(SSS).The SSS is distinguished by ...Existence of linear polarization,formed by anisotropic scattering in the photosphere,has been demonstrated observationally as well as theoretically and is called second solar spectrum(SSS).The SSS is distinguished by its structure,which is rich in terms of information.In order to analyze the SSS,it is necessary to evaluate the(de)polarizing effect of isotropic collisions between CN solar molecules and electrons or neutral hydrogen atoms.This work is dedicated to calculations of the polarization transfer rates associated with CN-electron isotropic collisions.We show that usual rates serve as a proxy for polarization transfer rates.Then,we take advantage of available usual excitation collisional rates obtained via sophisticated quantum methods in order to derive the polarization transfer rates for the X^2Σ+-B^2Σ+(violet) and X^2Σ+-A^2Π(red) systems of CN.Our approach is based on the infinite order sudden(IOS)approximation and can be applied for other solar molecules.We discuss the effectiveness of collisions with electrons on the SSS of the CN lines.Our results contribute to reducing the degree of complication in modeling the formation of the SSS of CN.展开更多
Background:More than a decade of fire suppression has changed the structure of fire-adapted shrubland ecosystems in Spain’s National Parks,which are now at extreme risk of uncontrolled wildfires.Prescribed burning ca...Background:More than a decade of fire suppression has changed the structure of fire-adapted shrubland ecosystems in Spain’s National Parks,which are now at extreme risk of uncontrolled wildfires.Prescribed burning can mitigate the risk of wildfires by reducing the fuel load but prescribed burning may also alter the soil properties and reduce microbial and fungal activity,causing changes in the availability of nutrients deep in the soil layer.Although fungal communities are a vital part of post-fire restoration,some fire effects remain unclear.To examine the short-term effects of prescribed burning on soil fungal communities in Doñana Biological Reserve(SW Spain),we collected soil samples pre-burn and 1 day,6 and 12 months post-burn from burned plots to perform physicochemical and metabarcode DNA analyses.Results:Prescribed burning had no significant effect on the total fungal operational taxonomic unit richness and abundance.However,changes in soil pH,nitrogen and potassium content post-burn affected fungal community composition.Small non-significant changes in pH and phosphorous affected the composition of ectomycorrhizal fungi.Conclusions:The ectomycorrhizal fungal community appears to be resilient to the effects of low-to moderate-intensity fires and saprotrophic taxa may benefit from this kind of fire.This finding revealed that prescribed burning is a potentially valuable management tool for reducing fire hazards in shrublands that has little effect on the total richness and abundance of fungal communities.展开更多
Water regime of Albanian rivers is a Mediterranean typical one. During the wet period, it flows 85%-90% of the annual flow and the dry period represents only 10%-15% of the annual amount. In this paper the water regim...Water regime of Albanian rivers is a Mediterranean typical one. During the wet period, it flows 85%-90% of the annual flow and the dry period represents only 10%-15% of the annual amount. In this paper the water regime of the Semani and Vjosa River is analyzed. These are two rivers with total different hydro-geological characteristics. Vjosa river watershed is mainly composed of massif calcareous rocks that are streaky and karstifled. A totally different view is in the other river, in Seman where the impermeable rocks dominate. Even the distribution of the precipitation is quite different. In the Vjosa River the amount of the precipitation varies from 1,500 mm to 2,500 mm per year and in Semani River only 1,100 mm per year. The flow in the wet period is mainly a result of the precipitation and the minimum discharge occurs during the dry period representing the base flow that is the contribution from the groundwater. In this point of view the flow in the dry period is also an indicator of the underground water resource. During the dry period the watershed gives what it received and what has cumulated during the wet period. This is more evident in the case of a karstic watershed. The recession curves were analysed for all the hydrometric stations in both river basins and the parameters of these curves are evaluated. These results are analyzed and compared between the two different watersheds reflecting the differences on water exchange of surface and ground water. Finally, an assessment of groundwater resources in both hydro geological basins is worked out.展开更多
Geographic information systems(GIS)are computer systems used to acquire,store,analyze and display of geographical data.They can provide support to the activities of a forestry consortium,which needs to plan its work i...Geographic information systems(GIS)are computer systems used to acquire,store,analyze and display of geographical data.They can provide support to the activities of a forestry consortium,which needs to plan its work in relation to the territory it manages.This article will illustrate the case study of the Canavese Forestry Consortium by analyzing the sources of the data it uses and the operations it does with them.Finally,this work will give an insight on further GIS instruments that can be used to support its activity.The activities carried out during the experimentation have entered into the ordinary activities of the consortium,which now uses the technologies described.It is considered that these indications can become patrimony for other similar cases.展开更多
Escherichia coli type 1 was used as a model system to determine whether static magnetic fields are a general stress factor. The bacterial broth culture were exposed to different magnetic force （400, 800, 1200 and 160...Escherichia coli type 1 was used as a model system to determine whether static magnetic fields are a general stress factor. The bacterial broth culture were exposed to different magnetic force （400, 800, 1200 and 1600 Gauss） with incubation at 37 ℃ for different times （24, 48 and 72 hrs） under aerobic conditions. The response of the cells to the magnetic fields was estimated from the change in total protein synthesis by using spectrophotometer at 550 nm and by using of SDS-PAGE （Sodium dodecyl sulfate- polyacrylamide gel electrophoresis）. Results concluded that was approximately no reproducible changes qualitatively in extracellular proteins were observed in the SDS-PAGE electrophoresis and did not act as a general stress factor. While, increases in the level of extra-cellular synthesis were observed using different magnetic field exposed samples when compared with the control.展开更多
We studied the biological effects of different magnetic fields. Identified bacterial strain Escherichia coli （type I） has been exposed to the dipolar magnetic field force （400, 800, 1200 and 1600 Gausses） which pr...We studied the biological effects of different magnetic fields. Identified bacterial strain Escherichia coli （type I） has been exposed to the dipolar magnetic field force （400, 800, 1200 and 1600 Gausses） which prepared locally with incubation for different period times （24, 48 and 72 hrs） at 37℃. The effects were evaluated by optical density （OD） at 600 nm determining their growth density incorporation with negative control and depending of McFarland turbidity standard （0.5）, in addition to its susceptibility to various antibiotics. Results illustrate different forces of magnetic field decreased the growth rate of E. coli in particular at 24 hrs incubation comparing with unexposed or control samples. The magnetic field increased the logarithmic phase within 4-6 hrs of treatment but decreased after 16 to 18 hrs. Furthermore, changes in the antibiotic sensitivity were observed after exposure period of 6 hrs since E. coli cells became more sensitive to certain antibiotics. While after a 16 hrs exposure period, it became more resistant to the same antibiotics comparing with control groups.展开更多
<span style="font-family:Verdana;">The purpose of this paper is to review relevant literature concerning limb length inequalities in adults and to make recommendations for assessment and intervention b...<span style="font-family:Verdana;">The purpose of this paper is to review relevant literature concerning limb length inequalities in adults and to make recommendations for assessment and intervention based on the literature and our own clinical experience. The research was carr</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ied</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> out on PUB MED, Non-English articles and duplicates in the databases were not included. Limb length inequality and common classification criteria are defined and etiological factors are present. Common methods of detecting limb length inequality include model manual technics. </span><span style="font-family:Verdana;">This work has the purpose of describing a well standardized therapeutic in the form of practical guidance. The approach we describe provides standardized model evaluation for leg lower limb in order to be used in rehabilitation </span><span style="font-family:Verdana;">clinic.</span></span></span></span>展开更多
文摘Osteoradionecrosis of the temporal bone(ORN-TB)is usually controlled with conservative measures.However,a temporal bone resection may be required in unresponsive cases.The reconstruction of the resulting defects may be challenging because of the radiation damage to regional tissues.As a result,distant free flaps may be an optimal choice.For instance,the gracilis muscular free flap(GMFF)has consistent vascular anatomy and can be used to reconstruct small defects.We report three cases of uncontrolled ORN-TB requiring an extensive temporal bone resection followed by vascularized obliteration with a GMFF.The patients reported complete control of the main otologic symptoms(otorrhea,otalgia,and aural fullness)and optimal functional and aesthetic outcomes.Finally,the patients reported significant improvement in quality of life despite early postoperative complications.To our knowledge,the GMFF had not been used to obliterate temporal bone defects in patients with ORN-TB.
文摘The online version of the original article can be found at:https://www.sciopen.com/article/10.26599/JOTO.2025.9540018 Erratum to Journal of Otology,2025,20(2):123-126.https://doi.org/10.26599/JOTO.2025.9540018 The surnames and given names of these authors are reversed:Saro-Buendía Miguel,Andresen-Lorca Belén,Pérez-García Alberto,Llópez Carratala Nacho,Carreres Polo Joan,Armengot Carceller Miguel,Perolada Valmaña Jose María.It should be Miguel Saro-Buendía,Belén Andresen-Lorca,Alberto Pérez-García,Nacho Llópez Carratala,Joan Carreres Polo,Miguel Armengot Carceller,Jose María Perolada Valmaña.
基金Supported by Universidad Cardenal Herrera-CEU,CEU Universities,No.GIR24/27。
文摘BACKGROUND Childhood trauma and parental socialization have been postulated as environmental factors of at-risk mental state(ARMS).Parental socialization is the process through which parents shape children’s self-regulation by providing guidance and protection.Although the impact of trauma on ARMS has been theorized,its clinical implications have not yet been fully clarified in adolescence,nor have explanatory models of parenting styles been established.AIM To investigate the role of traumatic experiences in the appearance of ARMS in the general adolescent population,considering the influence of parental socialization.METHODS A cross-sectional study of 697 adolescents aged 11-15 years was conducted,during which several questionnaires assessing childhood trauma,psychotic symptoms,and parenting styles were administered.The sample was divided into control,low-risk,medium-risk,and high-risk groups.RESULTS Some 2.8%(n=19)of the adolescents presented ARMS and the presence of childhood trauma was associated with an increased risk of ARMS.Furthermore,the presence of abuse was greater in the high-risk and low-risk groups compared to controls.Regarding parental socialization,it was determined that a family socialization style based on greater affection–communication decreased the probability of ARMS.Finally,using PROCESS model 1(regressionbased path analysis that uses ordinary least squares regression),results suggested that low levels of affection and communication may mediate the relationship between childhood trauma and ARMS in adolescents.CONCLUSION These results highlight the importance of the early detection of trauma in preventing ARMS,without forgetting the importance of socialization styles.
文摘This review summarizes the evidence about telemonitoring in patients with inflammatory bowel disease(IBD). To give an overview of the advances performed, as well as the enablers and barriers which favoured/hindered telemonitoring implementation. We performed a literature search in Pub Med, EMBASE, MEDLINE, Cochrane Database, Web of Science and Conference Proceedings. Titles and abstracts published up to September 2022 were screened for a set of inclusion criteria: telemonitoring intervention, IBD as the main disease, and a primary study performed. Ninety-seven reports were selected for full review. Finally, 20 were included for data extraction and critical appraisal. Most studies used telemonitoring combined with tele-education, and programs evolved from home telemanagement systems towards web portals through m Health applications. Web systems demonstrated patients’ acceptance, improvement in quality of life, disease activity and knowledge, with a good cost-effectiveness profile in the short-term. Initially, telemonitoring was almost restricted to ulcerative colitis, but new patient reported outcome measures, home-based tests and mobile devices favoured its expansion to different patients’ categories. However, technological and knowledge advances led to legal, ethical, economical and logistic issues. Standardization of remote healthcare is necessary, to improve the interoperability of systems as well as to address liability concerns and users’ preferences. Telemonitoring IBD is well accepted and improves clinical outcomes at a lower cost in the short-term. Funders, policymakers, providers, and patients need to align their interests to overcome the emerging barriers for its full implementation.
基金Project supported by the Key Lab of Geomechanics, Chinese Academy of Sciences (No.Z110202).
文摘The hybrid boundary node method （HBNM） is a promising method for solving boundary value problems with the hybrid displacement variational formulation and shape functions from the moving least squares（MLS） approximation. The main idea is to reduce the dimensionality of the former and keep the meshless advantage of the latter. Following its application in solving potential problems, it is further developed and numerically implemented for 2D solids in this paper. The rigid movement method is employed to solve the hyper-singular integrations. Numerical examples for some 2D solids have been given to show the characteristics. The computation results obtained by the present method are in excellent agreement with the analytical solution. The parameters that influence the performance of this method are studied through numerical examples.
文摘AIM： To determine the presence of symptomatic accommodative and non-strabismic binocular dysfunctions （A.sBD） in a non-presbyopic population of video display unit （VDU） users with flat-panel displays. METHODS： One hundred and one VDU users, aged between 20 to 34y, initially participated in the study. This study excluded contact-lens wearers and subjects who had undergone refractive surgery or had any systemic or ocular disease. First, subjects were asked about the type and nature of eye symptoms they experienced during VDU use. Then, a thorough eye examination excluded those subjects with a significant uncorrected refractive error or other problem, such as ocular motility disorders, vertical deviation, strabismus and eye diseases. Finally, the remaining participants underwent an exhaustive assessment of their accommodative and binocular vision status. RESULTS： Eighty-nine VDU users （46 females and 43 males） were included in this study. They used flat-panel displays for an average of 5±1.9h a day. Twenty subjects presented A.sBD （22.5%）. Convergence excess was the most frequent non-strabismic binocular dysfunction （9 subjects）, followed by fusional vergence dysfunction （3 subjects） and convergence insufficiency （2 subjects）. Within the accommodative dysfunctions, accommodative excess was the most common （4 subjects）, followed by accommodative insufficiency （2 subjects）. Moderate to severe eye symptoms were found in 13 subjects with ANSBD. CONCLUSION： Significant eye symptoms in VDU users with accommodative and/or non-strabismic binocular dysfunctions often occur and should not be underestimated; therefore, an appropriate evaluation of accommodative and binocular vision status is more important for this population,
文摘The aim of this paper is to determine the role of enzymatic vitrectomy performed by intravitreal injection of autologous plasmin enzyme(APE)in the management of diabetic retinopathy and diabetic macular edema(DME).Diabetic patients with proliferative diabetic retinopathy or DME and evident posterior hyaloid adherence to the retinal surface were included.All cases were treated with an initial intravitreal injection of APE and reevaluated one month later,measuring changes in best-corrected visual acuity(BCVA),macular thickness and the status of the posterior hyaloid.A second APE injection was performed in cases with no evident posterior vitreous detachment(PVD)after the initial treatment.Sixty-three eyes were included in the present review.A complete PVD appeared in 38%of cases(24 eyes)after one injection of plasmin and the total increased to 51%(32 eyes)after the second injection,separated at least by one month.The central macular thickness improved in all cases(100%)and BCVA in89%.Finally,in 50%of eyes with proliferative diabetic retinopathy,a high reduction of new vessels regression was observed.Enzymatic vitrectomy could be considered a good therapeutic alternative in diabetic retinopathy and macular edema.
基金the European Project opti Truck(optimal fuel consumption with predictive power train control and calibration for intelligent Truck)of the H2020 innovation programme。
文摘Driving style,traffic and weather conditions have a significant impact on vehicle fuel consumption and in particular,the road freight traffic significantly contributes to the CO2 increase in atmosphere.This paper proposes an Eco-Route Planner devoted to determine and communicate to the drivers of Heavy-Duty Vehicles(HDVs)the eco-route that guarantees the minimum fuel consumption by respecting the travel time established by the freight companies.The proposed eco-route is the optimal route from origin to destination and includes the optimized speed and gear profiles.To this aim,the Cloud Computing System architecture is composed of two main components:the Data Management System that collects,fuses and integrates the raw external sources data and the Cloud Optimizer that builds the route network,selects the eco-route and determines the optimal speed and gear profiles.Finally,a real case study is discussed by showing the benefit of the proposed Eco-Route planner.
文摘Gastroesophageal reflux disease (GERD) is a chronic digestive disorder that affects a growing number of people in the world and is one of the most common gastric complaints that prompts an individual to consult a doctor. Heartburn and regurgitation are the most predominant esophageal symptoms of GERD, but patients with the disease may also have extra esophageal symptoms, such as epigastric pain, bronchospasm, and chronic cough. All of these symptoms may compromise health-related quality of life with modification of eating habits and sleep pattern that have a great impact on the normal daily. Furthermore, GERD is a multifactorial disease that can be complicated and difficult to treat. Mechanical, chemical, physiopathologic, and functional factors that predispose patients to the disease are still under investigation. A simple treatment plan for manual therapists is presented based on current evidence-based literature;it is designed to reduce symptoms of GERD through somatovisceral approach and the nutrition.
文摘The size evolution of gold nanoparticles synthesized using tannic acid with initial gold chloride concentrations ranging from 0.2 - 2 mM at various tannic acid to chloroauric acid molar ratios (ranging from 2:1 to 12:1) has been analysed. Dynamic light scattering spectroscopic and tramission electron microscopic analyses were performed to assess the size of formed gold nanoparticles. Two different patterns of nanoparticle size evolution were obtained;the size evolution trend below 1 mM chloroauric acid concentration was found to be different from the one obtained at gold chloride concentrations higher than or equal to 1 mM. In case of sizes obtained for less than 1 mM gold chloride concentration, a general decrease in particle size was observed with increase in gold salt concentration. On the contrary, for the particles synthesised using chloroauric acid concentrations higher than or equal to 1 mM, with increase in gold salt concentration, a general increase in nanoparticle diameter was seen. For the molarities 0.2 and 0.5 mM, with increase in tannic acid/ chloroauric acid ratios, first the size decreases and then increases and finally reaches saturation. Particles formed at molarities greater than equal to 1 mM do not exhibit plateaux in their size rather initially decrease and then increase in response to increasing tannic acid/chloroauric acid ratios except for 2 mM concentration at which a small saturation is observed. The findings enumerate that higher gold chloride concentrations leave a significant impact on the sizes of gold nanaparticles obtained using tannic acid as a reducing agent of chloroauric acid solution.
文摘Background:Hepatectomy in patients with large tumor load may result in postoperative liver failure and associated complications due to excessive liver parenchyma removal.Conventional two-stage hepatectomy(TSH)and associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique are possible solutions to this problem.Colorectal liver metastases(CRLM)is the most frequent indication,and there is a need to assess outcomes for both techniques to improve surgical and long-term oncological outcomes in these patients.Methods:A single-center retrospective study was designed to compare TSH with ALPPS in patients with initially unresectable bilateral liver tumors between January 2005 and January 2020.ALPPS was performed from January 2012 onwards as the technique of choice.Long-term overall survival(OS)and disease-free survival(DFS)were evaluated as primary outcome in CRLM patients.Postoperative morbidity,mortality and liver growth in all patients were also evaluated.Results:A total of 38 staged hepatectomies were performed:17 TSH and 21 ALPPS.Complete resection rate was 76.5%(n=13)in the TSH group and 85.7%(n=18)in the ALPPS group(P=0.426).Overall major morbidity(Clavien-Dindo≥3 a)(stage 1+stage 2)was 41.2%(n=7)in TSH and 33.3%(n=7)in ALPPS patients(P=0.389),and perioperative 90-day mortalities were 11.8%(n=2)vs.19.0%(n=4)in each group,respectively(P=0.654).Intention-to-treat OS rates at 1 and 5 years in CRLM patients for TSH(n=15)were 80%and 33%,and for ALPPS(n=17)76%and 35%,respectively.DFS rates at 1 and 5 years were 36%and 27%in the TSH group vs.33%and 27%in the ALPPS group,respectively.Conclusions:ALPPS is an effective alternative to TSH in bilateral affecting liver tumors,allowing higher resection rate,but patients must be carefully selected.In CRLM patients similar long-term OS and DFS can be achieved with both techniques.
文摘Dear Editor, Polyorchidism refers to the presence of more than two testicles. Blasius described it for the first time in 1670 as an incidental finding in an autopsy, while Lane was the one who performed the first histological description of a supernumerary testis in 1895.1,2 Before imaging diagnosis techniques, this condition could only be verified under surgical exploration. Nowadays, current imaging techniques have increased the number of diagnosis of this anatomical variation. On the other hand, there is still a certain group of physicians who use histological analysis as the unioue way to diagnosis.
文摘Objective: Extracorporeal shockwave lithotripsy (SWL) currently plays an important role in the treatment of urinary tract lithiasis. The purpose of this article was to describe new concepts and procedural strategies that would improve results using SWL as a treatment for urolithiasis, thereby achieving better clinical practice.Methods: A systematic review process was carried in PubMed/PMC from January 2003 to March 2023. A narrative synthesis of the most important aspects has been made.Results: The important recommendations for the adequate selection of the candidate patient for treatment with SWL are summarized, as well as the new strategies for a better application of the technique. Aspects about intraoperative position, stone localization and monitoring, analgesic control, machine and energy settings, and measures aiming at reduced risk of complications are described.Conclusion: To achieve the therapeutic goal of efficient stone disintegration without increasing the risk of complications, it is necessary to make an adequate selection of patients and to pay special attention to several important factors in the application of treatment. Technological development in later generation devices will help to improve current SWL results.
基金funded by the Deanship of Scientific Research(DSR)at King Abdulaziz University,Jeddah,under grant no.(G:194-130-1441)。
文摘Existence of linear polarization,formed by anisotropic scattering in the photosphere,has been demonstrated observationally as well as theoretically and is called second solar spectrum(SSS).The SSS is distinguished by its structure,which is rich in terms of information.In order to analyze the SSS,it is necessary to evaluate the(de)polarizing effect of isotropic collisions between CN solar molecules and electrons or neutral hydrogen atoms.This work is dedicated to calculations of the polarization transfer rates associated with CN-electron isotropic collisions.We show that usual rates serve as a proxy for polarization transfer rates.Then,we take advantage of available usual excitation collisional rates obtained via sophisticated quantum methods in order to derive the polarization transfer rates for the X^2Σ+-B^2Σ+(violet) and X^2Σ+-A^2Π(red) systems of CN.Our approach is based on the infinite order sudden(IOS)approximation and can be applied for other solar molecules.We discuss the effectiveness of collisions with electrons on the SSS of the CN lines.Our results contribute to reducing the degree of complication in modeling the formation of the SSS of CN.
基金Spanish R&D projects MYCOINFOR(Mycosilviculture Applied to Forest Fire Prevention in Mediterranean SystemsPID2019-105188RB-I00)+4 种基金VIS4FIRE(Comprehensive vulnerability of forest systems to fire:implications for forest management toolsRTA2017-00042-C05-01)Interreg-POCTEP CILIFO(Iberian Centre for Research and Forest Firefighting0753-CILIFO-5-E)financed by European Social Fund“NextGenerationEU”through a grant“Margarita Salas”awarded to Juncal Espinosa into the project GFIRE。
文摘Background:More than a decade of fire suppression has changed the structure of fire-adapted shrubland ecosystems in Spain’s National Parks,which are now at extreme risk of uncontrolled wildfires.Prescribed burning can mitigate the risk of wildfires by reducing the fuel load but prescribed burning may also alter the soil properties and reduce microbial and fungal activity,causing changes in the availability of nutrients deep in the soil layer.Although fungal communities are a vital part of post-fire restoration,some fire effects remain unclear.To examine the short-term effects of prescribed burning on soil fungal communities in Doñana Biological Reserve(SW Spain),we collected soil samples pre-burn and 1 day,6 and 12 months post-burn from burned plots to perform physicochemical and metabarcode DNA analyses.Results:Prescribed burning had no significant effect on the total fungal operational taxonomic unit richness and abundance.However,changes in soil pH,nitrogen and potassium content post-burn affected fungal community composition.Small non-significant changes in pH and phosphorous affected the composition of ectomycorrhizal fungi.Conclusions:The ectomycorrhizal fungal community appears to be resilient to the effects of low-to moderate-intensity fires and saprotrophic taxa may benefit from this kind of fire.This finding revealed that prescribed burning is a potentially valuable management tool for reducing fire hazards in shrublands that has little effect on the total richness and abundance of fungal communities.
文摘Water regime of Albanian rivers is a Mediterranean typical one. During the wet period, it flows 85%-90% of the annual flow and the dry period represents only 10%-15% of the annual amount. In this paper the water regime of the Semani and Vjosa River is analyzed. These are two rivers with total different hydro-geological characteristics. Vjosa river watershed is mainly composed of massif calcareous rocks that are streaky and karstifled. A totally different view is in the other river, in Seman where the impermeable rocks dominate. Even the distribution of the precipitation is quite different. In the Vjosa River the amount of the precipitation varies from 1,500 mm to 2,500 mm per year and in Semani River only 1,100 mm per year. The flow in the wet period is mainly a result of the precipitation and the minimum discharge occurs during the dry period representing the base flow that is the contribution from the groundwater. In this point of view the flow in the dry period is also an indicator of the underground water resource. During the dry period the watershed gives what it received and what has cumulated during the wet period. This is more evident in the case of a karstic watershed. The recession curves were analysed for all the hydrometric stations in both river basins and the parameters of these curves are evaluated. These results are analyzed and compared between the two different watersheds reflecting the differences on water exchange of surface and ground water. Finally, an assessment of groundwater resources in both hydro geological basins is worked out.
文摘Geographic information systems(GIS)are computer systems used to acquire,store,analyze and display of geographical data.They can provide support to the activities of a forestry consortium,which needs to plan its work in relation to the territory it manages.This article will illustrate the case study of the Canavese Forestry Consortium by analyzing the sources of the data it uses and the operations it does with them.Finally,this work will give an insight on further GIS instruments that can be used to support its activity.The activities carried out during the experimentation have entered into the ordinary activities of the consortium,which now uses the technologies described.It is considered that these indications can become patrimony for other similar cases.
文摘Escherichia coli type 1 was used as a model system to determine whether static magnetic fields are a general stress factor. The bacterial broth culture were exposed to different magnetic force （400, 800, 1200 and 1600 Gauss） with incubation at 37 ℃ for different times （24, 48 and 72 hrs） under aerobic conditions. The response of the cells to the magnetic fields was estimated from the change in total protein synthesis by using spectrophotometer at 550 nm and by using of SDS-PAGE （Sodium dodecyl sulfate- polyacrylamide gel electrophoresis）. Results concluded that was approximately no reproducible changes qualitatively in extracellular proteins were observed in the SDS-PAGE electrophoresis and did not act as a general stress factor. While, increases in the level of extra-cellular synthesis were observed using different magnetic field exposed samples when compared with the control.
文摘We studied the biological effects of different magnetic fields. Identified bacterial strain Escherichia coli （type I） has been exposed to the dipolar magnetic field force （400, 800, 1200 and 1600 Gausses） which prepared locally with incubation for different period times （24, 48 and 72 hrs） at 37℃. The effects were evaluated by optical density （OD） at 600 nm determining their growth density incorporation with negative control and depending of McFarland turbidity standard （0.5）, in addition to its susceptibility to various antibiotics. Results illustrate different forces of magnetic field decreased the growth rate of E. coli in particular at 24 hrs incubation comparing with unexposed or control samples. The magnetic field increased the logarithmic phase within 4-6 hrs of treatment but decreased after 16 to 18 hrs. Furthermore, changes in the antibiotic sensitivity were observed after exposure period of 6 hrs since E. coli cells became more sensitive to certain antibiotics. While after a 16 hrs exposure period, it became more resistant to the same antibiotics comparing with control groups.
文摘<span style="font-family:Verdana;">The purpose of this paper is to review relevant literature concerning limb length inequalities in adults and to make recommendations for assessment and intervention based on the literature and our own clinical experience. The research was carr</span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">ied</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> out on PUB MED, Non-English articles and duplicates in the databases were not included. Limb length inequality and common classification criteria are defined and etiological factors are present. Common methods of detecting limb length inequality include model manual technics. </span><span style="font-family:Verdana;">This work has the purpose of describing a well standardized therapeutic in the form of practical guidance. The approach we describe provides standardized model evaluation for leg lower limb in order to be used in rehabilitation </span><span style="font-family:Verdana;">clinic.</span></span></span></span>
