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药物联合植物性护肤品治疗多形性日光疹48例疗效观察 被引量:3
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作者 李思彤 刘海洋 +4 位作者 涂颖 徐丹 冯家褀 Philippe HUMBERT 何黎 《中国皮肤性病学杂志》 CAS CSCD 北大核心 2016年第1期102-104,共3页
目的探讨药物联合植物性护肤品治疗多形性日光疹的疗效及安全性。方法多形性日光疹患者96例,随机分为实验组(48例)和对照组(48例),所有患者均给予相同口服药(羟氯喹400 mg/d,分2次服用,氯雷他定5 mg/d,口服4周)及外用药物(糠酸莫米松乳... 目的探讨药物联合植物性护肤品治疗多形性日光疹的疗效及安全性。方法多形性日光疹患者96例,随机分为实验组(48例)和对照组(48例),所有患者均给予相同口服药(羟氯喹400 mg/d,分2次服用,氯雷他定5 mg/d,口服4周)及外用药物(糠酸莫米松乳膏外搽患处,使用2周后,改为外搽氟芬那酸丁酯软膏2周,均每天涂搽2次)。实验组患者在药物治疗的同时均使用植物性护肤品,对照组仅给予药物治疗。于治疗2周后、4周后评价2组疗效。治疗后对所有患者进行随访4周观察其复发率。根据患者临床症状和体征(包括皮损面积大小、红斑丘疹、浸润程度、瘙痒程度)进行疗效评判。结果治疗4周后,实验组有效率为47.92%,对照组有效率为33.33%,两组疗效比较差异有统计学意义(P<0.05)。随访后发现实验组复发率(37.50%)明显较对照组(75.00%)低,差异有统计学意义(P<0.05)。所有患者用药和护肤品期间均未出现严重的不良反应。结论药物联合植物性护肤品治疗多形性日光疹疗效较好,安全性高。 展开更多
关键词 多形性日光疹 植物性护肤品 疗效
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泡球蚴感染过程中宿主CD_4^+细胞凋亡和凋亡相关基因转录水平的研究 被引量:19
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作者 李富荣 石佑恩 +2 位作者 史大中 DA Vuitton PS Craig 《中国人兽共患病杂志》 CAS CSCD 北大核心 2003年第4期59-62,65,共5页
目的 为了探讨泡球蚴感染宿主CD+ 4 淋巴细胞缺失的机制 ,以及泡球蚴感染与宿主CD+ 4 淋巴细胞凋亡及凋亡相关基因转录水平的相关性。方法 利用尼龙柱和补体法从泡球蚴感染 12周 ,2 5周和正常对照组BALB/c小鼠脾脏分离出纯CD+ 4 ,CD+ ... 目的 为了探讨泡球蚴感染宿主CD+ 4 淋巴细胞缺失的机制 ,以及泡球蚴感染与宿主CD+ 4 淋巴细胞凋亡及凋亡相关基因转录水平的相关性。方法 利用尼龙柱和补体法从泡球蚴感染 12周 ,2 5周和正常对照组BALB/c小鼠脾脏分离出纯CD+ 4 ,CD+ 8细胞 ,在体外分别经EmAg ,anti-CD3 ,IL - 2 ,TNFα ,PWM刺激培养 16h ;Tunel和PI双染后 ,FCM分析凋亡细胞数 ;并用C -myc ,TGF - β ,bcl- 2cDNA探针检测感染 2 5周EmAg诱导CD+ 4 细胞的凋亡相关基因转录水平。结果 FCM分析 ,感染 12周组CD+ 4 ,CD+ 8细胞凋亡数同正常对照组无明显差别 (P >0 0 5 ) ,感染 2 5周组CD+ 4 细胞凋亡数较正常对照组显著增高 (P <0 0 1) ,也显著性高于同组CD+ 8细胞 (P <0 0 1)。CD+ 4 细胞内C -myc,TGF - βmRNA水平较正常对照组显著升高 (P <0 0 5 ) ,而bcl- 2mRNA水平则减弱 (P <0 0 5 )。结论 泡球蚴寄生宿主后期 ,可诱导宿主成熟T细胞中CD+ 4 细胞发生凋亡 ,使宿主处于免疫抑制状态。凋亡的形成与凋亡信号增加 ,抑制信号减弱所引起。 展开更多
关键词 泡球蚴感染 宿主 CD4^+ 细胞凋亡 凋亡相关基因 转录 T细胞亚群 核酸原位杂交
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Analytical Monitoring of the Chemicals Present in the Discharge Water Generated by the Surface Treatment Industry 被引量:1
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作者 Nadia Morin-Crini Coline Druart +2 位作者 Sophie Gavoille Celine Lagarrigue Gregorio Crini 《Journal of Environmental Protection》 2013年第7期53-60,共8页
Industrial discharge water, and especially that from the surface treatment industry (ST), contains non-negligible amounts of pollutants even though the legislation is fully respected. In spite of this, no detailed stu... Industrial discharge water, and especially that from the surface treatment industry (ST), contains non-negligible amounts of pollutants even though the legislation is fully respected. In spite of this, no detailed studies list the exact chemical composition of these effluents. The present study reports the results of analyses performed over a 6-month period involving 15 standard water parameters. Over 160 substances including 33 metals, 58 volatile organic compounds (VOCs), 16 polycyclic aromatic hydrocarbons (PAHs), 24 chlorophenols (CPs), 16 alkylphenols (APs), 5 chloroanilines (CAs) and 7 polychlorobiphenyls (PCBs) were monitored. The industrial effluents presented polycontamination involving metals, minerals and organics with a high degree of qualitative and quantitative variability. Of the 160 substances monitored, 46 were regularly found: 25 inorganics including 8 metals (Co, Cr, Cu, Fe, Ni, Pb, Sn, Zn) and 21 organics (4 PAHs, 10 VOCs, 4 CPs and 3 APs). Eighteen were systematically presented at quantifiable levels. 展开更多
关键词 Discharge Water Metal-Finishing Industry Hazardous Substances Analytical Monitoring
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Structural effects of reedbed grazing and its cessation on reed-nesting songbird densities
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作者 Thomas Pagnon Clemence Pechinot +5 位作者 Lea Sgro Jeremie Demay Remi Jullian Regis Gallais Brigitte Poulin Cyril Marmoex 《Avian Research》 SCIE CSCD 2024年第2期238-248,共11页
Reedbeds are crucial breeding habitats for vulnerable songbird species.Irrespective of their protection status,these habitats may be threatened by organic matter accumulation,progressively leading to structural homoge... Reedbeds are crucial breeding habitats for vulnerable songbird species.Irrespective of their protection status,these habitats may be threatened by organic matter accumulation,progressively leading to structural homoge-nization and habitat succession towards woodland.Managers prevent excessive litter build-up with various in-terventions opening-up the reedbeds,such as grazing,which may be detrimental or suitable for some reed bird species.We assessed the effects of extensive grazing by horses and its cessation in the medium and long terms on reedbed structure,and the consequences on reed-nesting songbird densities in Estagnol Nature Reserve,a pro-tected wetland near the French Mediterranean coast.We compared reedbed structural features between grazed,newly ungrazed and old-ungrazed plots.During nine years,we censused four songbird species in spring and collected water level data in the same survey plots.Grazing reduced reedbed extent,rejuvenated the vegetation with more short green stems on a thinner litter,and produced higher structural heterogeneity and discontinuity compared to long-lasting non grazing.Newly ungrazed plot showed intermediate effects.All surveyed songbird total densities were similar among plots while species numbers and densities differed.Grazed reedbed was more attractive to Moustached Warblers(Acrocephalus melanopogon)and Great Reed Warblers(Acrocephalus arundi-naceus),likely due to the large edges and the high vegetation structural heterogeneity.However,Moustached Warblers were more negatively affected by higher water level in grazed reedbed,presumably because flooding prevents litter foraging.The newly ungrazed reedbed was not preferred by any species.All warbler species were found under low density in the old-ungrazed reedbed,where Reed Buntings(Emberiza schoeniclus)were exclu-sively found.Food availability related to thick litter layer may explain this predilection.Common Reed Warblers(Acrocephalus scirpaceus)were found everywhere in similar densities.We conclude that reedbed management by extensive horse grazing and also its long-term cessation may benefit several songbird species.Within a context of wetland degradation and disappearance,both management strategies are useful to establish and maintain suitable habitats for reed-nesting songbird communities. 展开更多
关键词 Bird conservation Edge complexity Fragmentation Habitat management Horse grazing Phragmites australis Reed passerine
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Simulating Particle Swarm Optimization Algorithm to Estimate Likelihood Function of ARMA(1, 1) Model
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作者 Basad Ali Hussain Al-sarray 《Journal of Mathematics and System Science》 2015年第10期399-410,共12页
This paper present a simulation study of an evolutionary algorithms, Particle Swarm Optimization PSO algorithm to optimize likelihood function of ARMA(1, 1) model, where maximizing likelihood function is equivalent ... This paper present a simulation study of an evolutionary algorithms, Particle Swarm Optimization PSO algorithm to optimize likelihood function of ARMA(1, 1) model, where maximizing likelihood function is equivalent to maximizing its logarithm, so the objective function 'obj.fun' is maximizing log-likelihood function. Monte Carlo method adapted for implementing and designing the experiments of this simulation. This study including a comparison among three versions of PSO algorithm “Constriction coefficient CCPSO, Inertia weight IWPSO, and Fully Informed FIPSO”, the experiments designed by setting different values of model parameters al, bs sample size n, moreover the parameters of PSO algorithms. MSE used as test statistic to measure the efficiency PSO to estimate model. The results show the ability of PSO to estimate ARMA' s parameters, and the minimum values of MSE getting for COPSO. 展开更多
关键词 Particle Swarm Optimization algorithm Likelihood function ARMA(1 1) Model
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Artificial Chiral Nanostructure at Oblique Incidence
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作者 Mohamed Boutria Rachid Oussaid +1 位作者 Daniel Van Labeke Fadi Issam Baida 《Journal of Electrical Engineering》 2017年第1期20-26,共7页
We propose in this paper the design of artificial nanostructure chirality obtained by oblique illumination. This structure is based on anisotropic metamaterial having an optical activity induced by the special geometr... We propose in this paper the design of artificial nanostructure chirality obtained by oblique illumination. This structure is based on anisotropic metamaterial having an optical activity induced by the special geometry of the pattern and the incident beam. Starting from a non-chiral material, the artificial chirality is obtained thanks to the rectangular apertures which form the periodic perfect metal nanostructure (one layer) and the oblique incidence of the light beam. An extraordinary light transmission (93%) through the metal nanostructure is achieved by exciting the cavity modes. The extrinsic chirality obtained can be granted to the desired value by appropriately adjusting the geometric parameters and the angle of incidence. 展开更多
关键词 NANOSTRUCTURE optical activity extrinsic chirality metamaterial.
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Rank-Ordering of Topographic Variables Correlated with Temperature
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作者 Daniel Joly Benjamin Bois Klemen Zaksek 《Atmospheric and Climate Sciences》 2012年第2期139-147,共9页
Spatial variations in temperature may be ascribed to many variables. Among these, variables pertaining to topography are prominent. Thus various topographic variables were calculated from 50 m-resolution digital terra... Spatial variations in temperature may be ascribed to many variables. Among these, variables pertaining to topography are prominent. Thus various topographic variables were calculated from 50 m-resolution digital terrain models (DTMs) for three study areas in France and for Slovenia. The “classic” geomatic variables (altitude, aspect, gradient, etc.) are supplemented by the description of landforms (amplitude of humps and hollows). Special care is taken in managing collinearity among variables and building windows with different dimensions. Statistical processing involves linear regressions of daily temperatures taken as the response variables and six topographic variables (explanatory variables). Altitude accounts significantly for the spatial variation in temperatures in 90% of cases, except in the Gironde, a lowlying area (50%). The scale of landforms also appears to be highly correlated to the measured temperature. Variations in the frequency with which topographic descriptors account for temperatures are examined from several standpoints. Altitude is less frequently taken as an explanatory variable for spatial variation of temperatures in winter (75%) than in spring (80%) and late summer (85%). Minimum temperatures are influenced on average much more by the amplitude of humps and hollows (56%) than maximum temperatures (38%) are. The frequency with which these two landforms account for the spatial variation of temperature is reversed between the minima and maxima. 展开更多
关键词 Explanatory Variables TEMPERATURE TOPOGRAPHY COLLINEARITY Linear Regression
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Estimate of an Hypoelliptic Heat-Kernel outside the Cut-Locus in Semi-Group Theory
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作者 Remi Leandre 《Applied Mathematics》 2012年第12期2063-2070,共8页
We give a proof in semi-group theory based on the Malliavin Calculus of Bismut type in semi-group theory and Wentzel-Freidlin estimates in semi-group of our result giving an expansion of an hypoelliptic heat-kernel ou... We give a proof in semi-group theory based on the Malliavin Calculus of Bismut type in semi-group theory and Wentzel-Freidlin estimates in semi-group of our result giving an expansion of an hypoelliptic heat-kernel outside the cut-locus where Bismut’s non-degeneray condition plays a preominent role. 展开更多
关键词 Subriemannian Geometry Heat-Kernels
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Modelling and investigating memory immune responses in infectious disease.Application to influenza a virus and sarscov-2 reinfections
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作者 Mathilde Massard Bruno Saussereau +3 位作者 Catherine Chirouze Quentin Lepiller Raluca Eftimie Antoine Perasso 《Infectious Disease Modelling》 2025年第1期163-188,共26页
Understanding effector and memory immune responses against influenza A virus(IAV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections and reinfections is extremely important,given that they are no... Understanding effector and memory immune responses against influenza A virus(IAV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections and reinfections is extremely important,given that they are now endemic in the community.The goal of this study is to investigate the role of memory cells and antibodies in the immune responses against IAV and SARS-CoV-2 re-infections.To this end,we adapt a previously-published within-host mathematical model(Sadria&Layton,2021)for the primary immune response against SARS-CoV-2 infections,by including two types of memory immune cells,i.e.,memory CD8t T-cells and memory B-cells,and by parametrising the new model with values specific to the two viruses.We first investigate the long-term dynamics of the model by identifying the virus-free steady states and studying the conditions that ensure the stability of these states.Then,we investigate the transient dynamics of this in-host model by simulating different viral reinfection times:20 days,60 days and 400 days after the first encounter with the pathogen.This allows us to highlight which memory immune components have the greatest impact on the viral elimination depending on the time of reinfection.Our results suggest that memory immune responses have a greater impact in the case of IAV infections compared to SARS-CoV-2 infections.Moreover,we observe that the immune response after a secondary infection is more efficient when the reinfection occurs at a shorter time. 展开更多
关键词 Within-host model IMMUNOLOGY Covid-19 SARS-CoV-2 Influenza a Memory cells
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Adjustable Phase-Amplitude-Phase Acoustic Metasurface for the Implementation of Arbitrary Impedance Matrices
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作者 Yu-Ze Tian Zhuo-Run Wei +2 位作者 Yan-Feng Wang Vincent Laude Yue-Sheng Wang 《Research》 2025年第2期925-931,共7页
Impedance metasurfaces enable accurate regulation of acoustic fields.However,they can hardly supply a flexible response as such perfect operation is accompanied by stringent requirements on the design of unit cells.Ac... Impedance metasurfaces enable accurate regulation of acoustic fields.However,they can hardly supply a flexible response as such perfect operation is accompanied by stringent requirements on the design of unit cells.Actually,an arbitrary lossless and passive target impedance matrix requires the tuning of 3 independent real parameters.The set composed of a reflection phase,a transmission amplitude,and a transmission phase,enables the representation of an arbitrary impedance matrix,possibly possessing singular elements.In this paper,a mechanism of phase-amplitude-phase modulation(PAP modulation)is developed for the generic design of the unit cells of acoustic impedance metasurfaces.Adjustable acoustic impedance metasurfaces are further available under this framework.An impedance unit with 3 mobile parts is designed based on this idea.The assembled metasurface can handle different incidences for acoustic field manipulation at a given frequency.Beam steering and beam splitting are considered as demonstration examples and are verified by numerical simulation and experiment.PAP modulation enriches the design of acoustic impedance metasurfaces and extends the range of application of impedance theory. 展开更多
关键词 impedance matrix accurate regulation acoustic fieldshoweverthey design unit cellsactuallyan representation arbitrary impedance matrixpossibly impedance metasurfaces acoustic field manipulation tuning independent real parametersthe adjustable phase amplitude phase modulation
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Weighted variation inequalities for differential operators and singular integrals in higher dimensions 被引量:9
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作者 MA Tao TORREA Jose L. XU QuanHua 《Science China Mathematics》 SCIE CSCD 2017年第8期1419-1442,共24页
We prove weighted q-variation inequalities with 2<q<∞for sharp truncations of singular integral operators in higher dimensions.The vector-valued extensions of these inequalities are also given.Parallel results ... We prove weighted q-variation inequalities with 2<q<∞for sharp truncations of singular integral operators in higher dimensions.The vector-valued extensions of these inequalities are also given.Parallel results are proven for differential operators. 展开更多
关键词 variation inequalities A_(p) weights differential operators singular integrals vector-valued variationin equalities
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Function approximation reinforcement learning of energy management with the fuzzy REINFORCE for fuel cell hybrid electric vehicles 被引量:3
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作者 Liang Guo Zhongliang Li +1 位作者 Rachid Outbib Fei Gao 《Energy and AI》 2023年第3期76-87,共12页
In the paper,a novel self-learning energy management strategy(EMS)is proposed for fuel cell hybrid electric vehicles(FCHEV)to achieve the hydrogen saving and maintain the battery operation.In the EMS,it is proposed to... In the paper,a novel self-learning energy management strategy(EMS)is proposed for fuel cell hybrid electric vehicles(FCHEV)to achieve the hydrogen saving and maintain the battery operation.In the EMS,it is proposed to approximate the EMS policy function with fuzzy inference system(FIS)and learn the policy parameters through policy gradient reinforcement learning(PGRL).Thus,a so-called Fuzzy REINFORCE algorithm is first proposed and studied for EMS problem in the paper.Fuzzy REINFORCE is a model-free method that the EMS agent can learn itself through interactions with environment,which makes it independent of model accuracy,prior knowledge,and expert experience.Meanwhile,to stabilize the training process,a fuzzy baseline function is adopted to approximate the value function based on FIS without affecting the policy gradient direction.More-over,the drawbacks of traditional reinforcement learning such as high computation burden,long convergence time,can also be overcome.The effectiveness of the proposed methods were verified by Hardware-in-Loop ex-periments.The adaptability of the proposed method to the changes of driving conditions and system states is also verified. 展开更多
关键词 Energy management strategy Fuel cell hybrid electric vehicle Reinforcement learning Fuzzy inference system Fuzzy policy gradient HARDWARE-IN-LOOP
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New distributions over Wiener and Euclidean spaces
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作者 P. Imkeller 严加安 《Science China Mathematics》 SCIE 1996年第9期925-934,共10页
Let (H, B, u) be an abstract Wiener space. New spaces of test functionals and distributions having kernels of the chaos decomposition in (Hn,n>0) are constructed. Their counterparts over Rm are completely character... Let (H, B, u) be an abstract Wiener space. New spaces of test functionals and distributions having kernels of the chaos decomposition in (Hn,n>0) are constructed. Their counterparts over Rm are completely characterized in terms of the H-transform. 展开更多
关键词 abstract WIENER space G-entire FUNCTION G-holomorphic FUNCTION S-TRANSFORM H-transform.
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