期刊文献+
共找到20,368篇文章
< 1 2 250 >
每页显示 20 50 100
Serological surveillance for SARS-CoV-2 antibodies among students,faculty and staff within a large university system during the pandemic
1
作者 Marcos G Pinheiro Gabriela G O Alves +18 位作者 Maria Eduarda R Conde Sofia L Costa Regina C S Sant’Anna Isa M F Antunes Mônica C Carneiro Fabio S Ronzei Julia C Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio C Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele C Alexandre Karla C de Paula Márcio Watanabe Antonio Claudio L da Nóbrega Jackeline Christiane P Lobato Fabio Aguiar-Alves 《World Journal of Virology》 2025年第1期99-107,共9页
BACKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2),which led to the outbreak of coronavirus disease 2019(COVID-19),associated with respiratory issues.Thi... BACKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2),which led to the outbreak of coronavirus disease 2019(COVID-19),associated with respiratory issues.This virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary lifestyle.Serological tests conducted early on have helped identify how the virus is transmitted and how to curb its spread.The study hypothesis was that the rapid serological test for SARS-CoV-2 antibodies could indicate the immunoreactive profile during the COVID-19 pandemic in a university population.AIM To conduct active surveillance for serological expression of anti-SARS-CoV-2 antibodies in individuals within a university setting during the COVID-19 pandemic.METHODS This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July 2021.The study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to participate.Data were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against SARS-CoV-2.Theχ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate associations.RESULTS A total of 1648 individuals were enrolled in the study.The proportion of COVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%CI:1.02-1.31](P<0.0024),individuals who had been in contact with a COVID-19-positive case(OR=3.49,95%CI:2.34-5.37)(P<0.001),those who had received the COVID-19 vaccine(OR=2.33,95%CI:1.61-3.35)(P<0.001)and social isolation(OR=0.59,95%CI:0.41-0.84)(P<0.004).The likelihood of showing a positive result increased by 16%with every ten-year increment.Conversely,adherence to social distancing measures decreased the likelihood by 41%.CONCLUSION These findings evidenced that the population became more exposed to the virus as individuals discontinued social distancing practices,thereby increasing the risk of infection for themselves. 展开更多
关键词 Serological surveillance SARS-CoV-2 antibodies COVID-19 Serological rapid test Risk factors for COVID-19
在线阅读 下载PDF
Association between Mental Distress and Weight-Related Self-Stigma via Problematic Social Media and Smartphone Use among Malaysian University Students: An Application of the Interaction of Person-Affect-CognitionExecution (I-PACE) Model 被引量:1
2
作者 Wan Ying Gan Wei-Leng Chin +10 位作者 Shih-Wei Huang Serene En Hui Tung Ling Jun Lee Wai Chuen Poon Yan Li Siaw Kerry S.O’Brien Iqbal Pramukti Kamolthip Ruckwongpatr Jung-Sheng Chen Mark D.Griffiths Chung-Ying Lin 《International Journal of Mental Health Promotion》 2025年第3期319-331,共13页
Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how i... Background:Weight-related self-stigma(WRSS)is prevalent among individuals with different types of weight status and is associated with a range of negative health outcomes.Social support and coping models explain how individuals may use different coping methods to deal with their mental health needs.Psychological distress(e.g.,depression and stress)could lead to overuse of social media and smartphones.When using social media or smartphones,individuals are likely to be exposed to negative comments regarding weight/shape/size posted on the social media.Consequently,individuals who experience problematic social media use(PSMU)or problematic smartphone use(PSPU)may develop WRSS.Therefore,the present study examined the roles of PSMU and PSPU as mediators in the relationship between psychological distress and WRSS.Methods:Using convenience sampling via an online survey,622 participants with a mean age of 23.70 years(SD=4.33)completed questions assessing sociodemographic variables,psychological distress,PSMU,PSPU,WRSS,and self-reported weight and height.Results:The hierarchical regression models showed that sex(β=0.08,p=0.01),BMI(β=0.39,p<0.001),depression(β=0.21,p=0.001),stress(β=0.18,p=0.01),PSMU(β=0.09,p=0.045),and PSPU(β=0.14,p=0.001)were significant factors for WRSS.Conclusion:The mediation models showed that both PSMU and PSPU were significant mediators in the relationships between depression and stress with WRSS.The present findings provide some evidence for understanding WRSS and has important implications for developing interventions to reduce its negative impact on individuals’health and well-being. 展开更多
关键词 Weight-related self-stigma stress coping theory I-PACE model depression stress social media use smartphone use
暂未订购
Kinematic Research on Hinged Synchronous Universal Joint Applied for Snake-like Manipulator
3
作者 王建滨 马培荪 +1 位作者 吴海平 郝颖明 《Journal of Donghua University(English Edition)》 EI CAS 2002年第4期124-127,共4页
The structure and motion principle of a hinged synchronous universal joint (HSUJ) is introduced, also whose kinematics is theoretically analyzed. As a result, a few kinematic characters of the HSUJ are obtained,which ... The structure and motion principle of a hinged synchronous universal joint (HSUJ) is introduced, also whose kinematics is theoretically analyzed. As a result, a few kinematic characters of the HSUJ are obtained,which establish the foundation of its application for snake-like manipulator. Making use of the HSUJ ss actuating mechauism, the developed snake-like manipulator has the merits of small curve radius, fewer actuator, and small volume etc. 展开更多
关键词 HYPER REDUNDANT degree of freedom snake-like MANIPULATOR SYNCHRONOUS universal joint
在线阅读 下载PDF
SOME DYNAMICAL PROPERTIES OF THE UNIVERSAL UNFOLDING OF PITCHFORK
4
作者 Zhu, ZY Ding, R 《Acta Mechanica Solida Sinica》 SCIE EI 1995年第4期356-363,共8页
From the point of view of dynamics, the phenomenon of mode jumping in the imperfect pitchfork problem is discussed. The dynamical mechanism of model jumping of structures, such as plate and shell, that is brought abou... From the point of view of dynamics, the phenomenon of mode jumping in the imperfect pitchfork problem is discussed. The dynamical mechanism of model jumping of structures, such as plate and shell, that is brought about by the extremum instability, is explained. Finally, we give numerical simulation to show the validity of our results. 展开更多
关键词 pitchfork bifurcation universal unfolding dynamical system mode jumping
在线阅读 下载PDF
Microbiological Quality of the Effluents Produced by the University and Hospital Centres in the Department of Littoral, Republic of Benin
5
作者 Judicae Todedji +6 位作者 Cyriaque Degbey Evelyne Soclo Arouna Yessoufou Jean Wilfried Hounfodji Ferdinand Goudjo Fidèle Suanon Daouda Mama 《Open Journal of Epidemiology》 2020年第1期66-80,共15页
Introduction: The effluents generated by hospital activities pose a potential danger to health and the environment. This study aimed to study the microbiological quality of the effluents produced by the university and... Introduction: The effluents generated by hospital activities pose a potential danger to health and the environment. This study aimed to study the microbiological quality of the effluents produced by the university and hospital centres of Littoral department. Methods: This was a descriptive cross-sectional study of 60 samples of hospital effluents from sewage treatment plants and septic tanks carried out during the period from April to June 2019. Samples at the station were made at the entrance and exit of the station. Samples for microbiological analysis were collected in pre-sterilized 500 mL glass bottles. Samples were kept between at 2&#176;C - 8&#176;C and in the dark to ensure satisfactory preservation. ANOVA one-way analysis of variance was performed for each microbiological parameter and principal component analysis (PCA) was also performed. Results: The bacteriological analyses carried out on the 60 samples taken showed a significant microbiological load. In fact, the bacteriological parameters measured and compared to the pollutant release standards in the environment show that the number of germs identified is above the recommended guideline values. The average values for total coliforms, faecal coliforms, faecal streptococci and staphylococci were: 3.91 × 105 UFC/100 mL, 0.52 × 105 UFC/100 mL, 3.92 × 105 UFC/100 mL and 1.36 × 105 UFC/100 mL, respectively. The most isolated bacteria were: Klebsiella pneumoniae, Klebsiella oxytoca, Escherichia coli, Enterococcus faecalis, Enterobacter cloacae, Pseudomonas horizyhabitans, Staphylococcus aureus and Staphylococcus saprophyticus. Most strains were resistant to at least 3 families of antibiotics (beta-lactams, aminoglycosides and fluoroquinolones). Conclusion: These effluents therefore present health and environmental risks. It is of utmost importance to develop methods for the treatment of these effluents before their release into the natural environment. 展开更多
关键词 Hospital Effluents GERMS Contamination University Hospital Center BENIN
暂未订购
Universal construction of control Lyapunov functions for a class of nonlinear systems 被引量:1
6
作者 Cai Xiushan Wang Xiaodong Zhang Haoran 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2007年第3期598-602,共5页
A method is developed by which control Lyapunov functions of a class of nonlinear systems can be constructed systematically. Based on the control Lyapunov function, a feedback control is obtained to stabilize the clos... A method is developed by which control Lyapunov functions of a class of nonlinear systems can be constructed systematically. Based on the control Lyapunov function, a feedback control is obtained to stabilize the closed-loop system. In addition, this method is applied to stabilize the Benchmark system. A simulation shows the effectiveness of the method. 展开更多
关键词 control Lyapunov functions nonlinear systems stabilization.
在线阅读 下载PDF
Choose one’s Professional Future and Sandwich Training in Higher Education: Experiences and Perspectives from CFA University in Corsica 被引量:2
7
作者 Christophe Storai Laetitia Rinieri 《Journal of Business Administration Research》 2019年第3期10-17,共8页
In France,the field of lifelong learning has undergone many changes since 2014 according to the laws that have been promulgated[Law No.2014-288 of 5 March 2014 on vocational training,employment and social democracy ht... In France,the field of lifelong learning has undergone many changes since 2014 according to the laws that have been promulgated[Law No.2014-288 of 5 March 2014 on vocational training,employment and social democracy https://www.legifrance.gouv.fr/affichTexte.do?cidTexte=-JORFTEXT000028683576&categorieLien=id;Law n°2018-771 of September 5,2018 for the freedom to choose one's professional future https://www.legifrance.gouv.fr/affichTexte.do?cidTexte=JORFTEXT000037367660&categorieLien=id.].While the reform on vocational training for employment and social democracy finalized the decentralization of vocational training by giving regions the means for a more coherent action and placed them as a pilot for the construction of training policies,the recent law for the freedom to choose one's professional future recentralises the regulation of continuing vocational training and sandwich courses.This development will not fail to impact the governance of the CFA,especially those of Higher Education anchored in the small territories.Faced with this major structural issue in the specific context of a small island economy,the University Center for Apprenticeship Training in the Corsican region strives,for a decade,to contribute to the enhancement of the professional integration of work-study students from the University of Corsica,by the development and the durability of determining factors characteristic of a small territorial area in search of structuration[Specially:increased employability and quality of professional integration of its human capital,demonstrated growth in the level of skills acquisition in line with the needs expressed by local socio-economic actors,transfer of relevant knowledge through the learning process,active incentive to entrepreneurial capacity.].After having highlighted the qualitative results resulting from the activity dynamics of the CFA University in Corsica,this contribution will analyze the perspectives drawn from the exemplary nature of the latter in the context of a new law that is supposed to contribute to the regional structuring of a knowledge and competence economy. 展开更多
关键词 Higher Education Sandwich training Occupational integration Vocational training Regional construction of an economy of knowledge and competence
在线阅读 下载PDF
The Vocational Integration of Students-Apprentices in the Context of a Pandemic Crisis:Feedback from the University CFA in Corsica
8
作者 Christophe Storai Laetitia Rinieri 《Journal of Business Administration Research》 2021年第4期1-14,共14页
The COVID-19 pandemic has generated major economic impacts in the vast majority of countries,including falling GDP and global trade,massive job losses,deficits and increased public debt.If quasi-generalized interventi... The COVID-19 pandemic has generated major economic impacts in the vast majority of countries,including falling GDP and global trade,massive job losses,deficits and increased public debt.If quasi-generalized interventionist economic policies have made it possible to cushion the paralysis of the productive devices,the short-term global outlook remains very uncertain.In this gloomy context,what will be the situation on the labour market,and in particular the vocational integration of students?Corsica presents the example of a small island territory in search of a regional development scheme based on the economy of knowledge and competence.In this major structural perspective,the University Apprenticeship Training Centre(CFA UNIV)in the Corsican region has been striving,for a decade,to contribute to the enhancement of studentsapprentices vocational integration from the University of Corsica.Within the scope of its activities,are the monitoring and evaluation of the students-apprentices’professional integration from the University of Corsica.Since 2011,the carrying out the annual surveys on studentsapprentices’future from the University of Corsica has demonstrated the capacity of the sandwich course training in Higher Education simultaneously to boost the employability of skilled human capital and the growth of local business structuring.This contribution will aim to synthesize ten years of CFA UNIV experience and will endeavour to analyse the localized consequences of a global pandemic crisis on the nature of the vocational integration studentapprentices from the University of Corsica in a small territory island. 展开更多
关键词 Higher education APPRENTICESHIP Vocational integration Students APPRENTICES
在线阅读 下载PDF
Predictive value of body fat estimation formula of Navarra University in bone mineral density with type 2 diabetes mellitus patients
9
作者 WU Xunan 《China Medical Abstracts(Internal Medicine)》 2025年第4期209-209,共1页
Objective To explore the correlation between body fat estimation formula of Navarra University(CUN-BAE)and bone mineral density(BMD)in patients with type 2 diabetes mellitus(T2DM)and its predictive value for osteoporo... Objective To explore the correlation between body fat estimation formula of Navarra University(CUN-BAE)and bone mineral density(BMD)in patients with type 2 diabetes mellitus(T2DM)and its predictive value for osteoporosis(OP).Methods A total of 428 patients with T2DM who were hospitalized in the Department of Endocrinology and Metabolism. 展开更多
关键词 bone mineral density type diabetes mellitus body fat estimation OSTEOPOROSIS type diabetes mellitus t dm bone mineral Navarra University formula body fat estimation formula
原文传递
New Era,New Village,New Planning:2024 Planning Practice Forum of Universities Alliance for Rural Development
10
作者 Wang Jian Luan Feng +10 位作者 Duan Degang Geng Hong Yang Xiaochun Leng Hong Saierjiang Halike Zhao Bing Luo Zhendong Shen Zhenjiang Ye Hong Liu Jinxin(Translated) Li Min(Translated) 《China City Planning Review》 2025年第3期6-22,共17页
Introduction The Annual Meeting of the Rural Planning Practice Committee of the Universities Alliance for Rural Development,along with the 2024 Rural Planning Practice Forum was successfully held at the Wang Zesheng L... Introduction The Annual Meeting of the Rural Planning Practice Committee of the Universities Alliance for Rural Development,along with the 2024 Rural Planning Practice Forum was successfully held at the Wang Zesheng Lecture Hall of the School of Architecture,Tsinghua University on Dec.15,2024.The annual theme“New Era,New Village,and New Planning”has brought together experts and scholars from 96 universities and research institutions across China.The discussions focused on rural planning practices and case studies in three distinct regions:metropolitan areas,major producing areas for agricultural products,and ecological conservation areas,in the context of national policies and socio-economic transformations in the new era.China City Planning Review(CCPR)has compiled the 11 distinguished experts'presentations to foster further discussions on these critical topics. 展开更多
关键词 new planning Wang Zesheng lecture hall planning practice forum universities alliance rural development Tsinghua University new era new village case stu
原文传递
中国学校体育自主知识体系构建的概念化路径
11
作者 周珂 乔石磊 +2 位作者 范峰 周艳丽 吴安月 《武汉体育学院学报》 北大核心 2026年第2期1-9,共9页
知识体系构建的过程是将理论思想和实践经验概念化的过程。从“自主”要求、“概念”诉求、“普遍”追求3个方面审思中国学校体育知识体系构建的逻辑起点、逻辑遵循以及逻辑指向。基于概念的视角,提出中国学校体育自主知识体系构建的具... 知识体系构建的过程是将理论思想和实践经验概念化的过程。从“自主”要求、“概念”诉求、“普遍”追求3个方面审思中国学校体育知识体系构建的逻辑起点、逻辑遵循以及逻辑指向。基于概念的视角,提出中国学校体育自主知识体系构建的具体路径:(1)深化主体意识,持续回应中国学校体育时代发展的实践问题;(2)明晰提炼过程,强调提炼中国学校体育本土概念的技术方法;(3)完善结构模型,系统搭建中国学校体育自主知识的概念谱系;(4)拓宽国际视野,重视提升中国学校体育话语体系的多元阐释。 展开更多
关键词 学校体育 自主知识体系 概念化 自主要求 概念诉求 普遍追求
在线阅读 下载PDF
自“形式连接”向“实质融合”:教育强国建设背景下中小学综合体育活动实施困境与突破路径
12
作者 陈海雄 汤长发 +1 位作者 张强峰 崔龙 《武汉体育学院学报》 北大核心 2026年第2期86-93,共8页
在梳理我国中小学综合体育活动实施形态、主要变化与价值体现基础上,借助“形式连接”向“实质融合”理论逻辑,剖析中小学综合体育活动实施困境及原因,并提出优化路径。研究发现,中小学综合体育活动“上学日校内加节假日校外”与“校内... 在梳理我国中小学综合体育活动实施形态、主要变化与价值体现基础上,借助“形式连接”向“实质融合”理论逻辑,剖析中小学综合体育活动实施困境及原因,并提出优化路径。研究发现,中小学综合体育活动“上学日校内加节假日校外”与“校内不够校外补”的两种实施形态,强化了学校的主体责任,学校教育主阵地进一步稳固。但总体来看,中小学综合体育活动的学校整体实施忙于时间累加,教师具体落实难免认知分歧,条件组织保障存在先天不足等形式连接困境,其原因在于系统整体设计欠缺、综合育人思维缺失,质量监控建设滞后,需要从压实学校主体责任、强化教师团队学习、变革学校组织文化等方面实现实质融合。 展开更多
关键词 教育强国建设 中小学 综合体育活动 形式连接 实质融合
在线阅读 下载PDF
滇中亚高山地带性森林土壤微生物碳利用效率对氮添加的响应
13
作者 张龙 梁小玲 +4 位作者 侯征 陈雯 王邵军 舒海苑 宋娅丽 《应用生态学报》 北大核心 2026年第2期427-440,共14页
土壤微生物碳利用效率(CUE)反映了微生物将吸收的碳分配用于生物量合成的比例。探究氮添加条件下土壤微生物CUE的变化,有助于深化对森林生态系统土壤碳固存潜力的理解。本研究以滇中亚高山常绿阔叶林和高山栎林土壤为研究对象,采用模拟... 土壤微生物碳利用效率(CUE)反映了微生物将吸收的碳分配用于生物量合成的比例。探究氮添加条件下土壤微生物CUE的变化,有助于深化对森林生态系统土壤碳固存潜力的理解。本研究以滇中亚高山常绿阔叶林和高山栎林土壤为研究对象,采用模拟氮添加试验,设置0(CK)、50(N_(50))、100(N_(100))、150(N_(150))、200(N_(200))、250 kg·hm^(-2)·a^(-1)(N_(250))6个添加水平,研究施氮后土壤化学性质、微生物量及胞外酶活性的动态变化特征,通过生物地球化学模型计算微生物CUE,分析土壤微生物CUE对氮添加的响应趋势。结果表明:氮添加下常绿阔叶林土壤微生物CUE大于高山栎林,且2个林分中土壤微生物CUE均为0~10 cm土层>10~20 cm土层。常绿阔叶林中土壤微生物CUE随氮添加量升高呈先增加后降低,比对照降低2.9%~41.3%;高山栎林则表现为高氮促进低氮抑制,在N_(200)和N_(250)处理下较对照显著增加8.1%和11.6%,其余处理较对照均降低。常绿阔叶林土壤微生物CUE的主要影响因子为土壤细菌和真菌群落α多样性及pH,而高山栎林则为土壤细菌和真菌群落α多样性以及土壤NO_(3)^(-)-N、pH。2种林分的优势类群不一致,群落结构变化对土壤微生物CUE产生显著影响。林分类型、氮添加水平及土层深度共同决定了常绿阔叶林和高山栎林CUE的动态变化,表明生态系统碳储存潜力对氮沉降的响应具有显著的生态特异性。 展开更多
关键词 氮添加 土壤微生物碳利用效率 土壤微生物群落 土壤酶活性 常绿阔叶林 高山栎林
原文传递
全面发展视域下中国体育人才培养“群竞协同”的关键要素与理论逻辑
14
作者 杜更 陶焘 《武汉体育学院学报》 北大核心 2026年第1期77-85,共9页
在“健康中国”与“体育强国”战略背景下,推动群众体育与竞技体育协同育人的机制已成为优化体育人才结构、促进体育高质量发展的重要议题。当前,我国体育人才培养体系仍存在群竞分离、结构割裂等问题,亟须理论重构与实践探索。研究基... 在“健康中国”与“体育强国”战略背景下,推动群众体育与竞技体育协同育人的机制已成为优化体育人才结构、促进体育高质量发展的重要议题。当前,我国体育人才培养体系仍存在群竞分离、结构割裂等问题,亟须理论重构与实践探索。研究基于“人的全面发展”理念,采用主题分析法,对2016-2025年间的政策文本、实践案例与学术文献进行编码分析,构建了“群竞协同”体育人才培养模型。研究发现,“群竞协同”系统由规则、行动、机制、赋能、调适与反馈六个核心要素构成。各要素围绕体育人才全面发展目标,通过“目标牵引、结构支撑、机制反馈”三重系统结构实现耦合互动与动态调节。该模型揭示了多元主体协同、资源整合及过程管理在体育人才培养中的关键作用,体现了协同育人的实践机制。研究不仅丰富了体育领域的系统协同理论,也为构建符合中国语境的育人体系提供了方法论支持与实践参考。 展开更多
关键词 体育人才培养 全面发展 群众体育 竞技体育 群竞协同 主题分析法
在线阅读 下载PDF
机遇、挑战、跨越:强国建设背景下民族传统体育传承发展研究
15
作者 白晋湘 《武汉体育学院学报》 北大核心 2026年第1期1-8,共8页
站在新的历史起点上,全面建成社会主义现代化强国已成为时代最强音。作为中华优秀传统文化的重要组成部分,民族传统体育在强国建设背景下如何实现跨越式发展,是一道必须回答好的时代命题。采用文献资料法、逻辑分析法等对当前民族传统... 站在新的历史起点上,全面建成社会主义现代化强国已成为时代最强音。作为中华优秀传统文化的重要组成部分,民族传统体育在强国建设背景下如何实现跨越式发展,是一道必须回答好的时代命题。采用文献资料法、逻辑分析法等对当前民族传统体育面临的时代机遇与现实挑战进行分析与阐释,认为:国家战略支持、文化复兴需求以及产业融合趋势等为民族传统体育传承发展带来重要支撑;而西方体育文化的长期冲击、文化传承与传播的乏力、产业化发展动能不足等问题也成为制约其高质量发展的阻碍。基于此,坚持以人民为中心的主线意识,践行以文化赓续为使命的应有态度,完善以强国建设为导向的运行机制,开拓以和谐共生为目标的产业格局,创新以科技赋能为支撑的技术变革等方法手段,是实现当代民族传统体育高质量发展的路向选择。 展开更多
关键词 强国建设 民族传统体育 文化赓续 传承发展
在线阅读 下载PDF
伴FGFR2基因易位的肝内胆管癌临床病理特征
16
作者 眭怡群 姚娟 +4 位作者 叶振宇 徐蒙蒙 王志明 张永胜 曹志飞 《临床与实验病理学杂志》 北大核心 2026年第3期297-303,共7页
目的探讨具有成纤维细胞生长因子受体2(fibroblast growth factor receptor 2,FGFR2)易位肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)的临床病理特点及分子特征。方法回顾性分析8例FGFR2易位ICC的临床表现、影像学检查、病理学特... 目的探讨具有成纤维细胞生长因子受体2(fibroblast growth factor receptor 2,FGFR2)易位肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)的临床病理特点及分子特征。方法回顾性分析8例FGFR2易位ICC的临床表现、影像学检查、病理学特点及分子特征,并与32例FGFR2易位阴性ICC病例进行对比分析。结果FGFR2易位ICC肿瘤细胞呈立方形或多边形,在纤维硬化性间质中呈相互吻合的管状、小梁状、实性巢状或乳头状生长。与FGFR2易位阴性者相比,FGFR2易位阳性ICC乙型肝炎病毒感染率更高(P=0.042),组织学亚型以小胆管型或混合型更常见(P=0.037),p53、HER2、c-Met、BRAF V600E蛋白突变率或表达率有降低趋势,但无统计学意义(P>0.05)。联合性别、乙型肝炎病毒感染、TNM分期、组织学亚型及肿瘤细胞核级预测FGFR2易位的受试者工作特征(receiver operating characteristic,ROC)曲线下面积为0.912(P<0.001),大于任意特征独立预测的曲线下面积。与TP53野生型FGFR2易位ICC相比,伴TP53共突变的FGFR2易位ICC肿瘤细胞核级更高(P=0.036),TNM分期更晚(P=0.036),总生存率更低(P=0.009)。结论独特的临床病理特征有助于FGFR2基因融合突变的筛选及识别出TP53共突变病例,为ICC患者提供更精准的治疗。 展开更多
关键词 肝内胆管癌 成纤维细胞生长因子受体2 基因易位 基因融合
暂未订购
数智赋能:竞技体育精准训练模式的构建与实践路径
17
作者 刘瑞 杨小丫 +3 位作者 李超 李若洋 冯莹莹 郑攀 《武汉体育学院学报》 北大核心 2026年第3期79-85,94,共8页
数智赋能精准训练是引领我国竞技体育由“经验驱动”向“数据驱动”转型的核心范式。运用文献资料法、逻辑分析法、案例分析法,针对资源消耗型增长、个性化挖掘不足以及学科知识碎片化等现实困境,系统阐释了数智赋能精准训练的实践逻辑... 数智赋能精准训练是引领我国竞技体育由“经验驱动”向“数据驱动”转型的核心范式。运用文献资料法、逻辑分析法、案例分析法,针对资源消耗型增长、个性化挖掘不足以及学科知识碎片化等现实困境,系统阐释了数智赋能精准训练的实践逻辑。研究认为,数智赋能精准训练的内涵可以分为数据驱动决策、应用增强、透明可视化、实时反馈及个性化定制五个维度。基于DIKW理论,本文揭示了训练数据从原始采集到智慧决策的价值演进机理,并构建了涵盖动态采集、算法引擎与价值验证的实践框架。实证研究表明,数智技术能有效实现状态预测与个性化调控,典型案例验证了其在竞技表现提升中的实效性。未来应通过夯实多模态数据集、构建冠军模型及强化人机协同,深度耦合技术理性与经验智慧,并前瞻布局数字孪生等趋势,全方位提升我国竞技体育的科学化训练水平。 展开更多
关键词 数智赋能 竞技体育 训练模式 精准训练
在线阅读 下载PDF
国际组织的制度性权力与国家主权的互构——基于中国与国际奥委会关系的演进研究
18
作者 霍传颂 陈龙 李雨洹 《武汉体育学院学报》 北大核心 2026年第1期17-25,共9页
在全球化与跨国相互依赖日益加深的背景下,国际组织的影响力显著增强,其与国家主权之间的张力与调适已成为国际关系研究的关键议题。以1952年以来中国与国际奥委会(IOC)的关系演进为核心案例,运用历史制度主义与建构主义的理论视角,剖... 在全球化与跨国相互依赖日益加深的背景下,国际组织的影响力显著增强,其与国家主权之间的张力与调适已成为国际关系研究的关键议题。以1952年以来中国与国际奥委会(IOC)的关系演进为核心案例,运用历史制度主义与建构主义的理论视角,剖析中国与IOC的互动关系史后发现:IOC的制度性权力与中国对国家主权的坚守,在不同历史时期呈现出从激烈碰撞、制度性对抗,到逐步调适、策略性融入,乃至积极塑造的演进轨迹。这一过程不仅揭示了IOC“政治中立”原则在复杂国际政治现实面前的内在矛盾与外部困境,也展现了中国作为崛起中的大国学习并运用国际规则、逐步提升国际话语权与影响力的历程。研究强调,国际组织的制度性权力与国家主权并非零和博弈,而是在持续互动中相互渗透、彼此形塑、共同演化。中国与IOC的案例为主权国家与国际组织关系,以及全球治理体系变革中的权力动态提供了独特的经验证据与理论启示。 展开更多
关键词 国际组织 制度性权力 国家主权 中国 国际奥委会
在线阅读 下载PDF
国家在场:冲绳空手文化流变的海外民族志考察
19
作者 杨长明 刘浩男 张红霞 《武汉体育学院学报》 北大核心 2026年第1期60-67,85,共9页
中国古代王朝对琉球的册封,使该地区从文化到治理长期处于中华文明的影响下,受此影响中国古代武术逐渐涵化为现阶段日本的空手文化。但是,近年来由于日本国内的行政干预,导致冲绳空手在文化溯源的认同方面出现日本民间与中日两国学界的... 中国古代王朝对琉球的册封,使该地区从文化到治理长期处于中华文明的影响下,受此影响中国古代武术逐渐涵化为现阶段日本的空手文化。但是,近年来由于日本国内的行政干预,导致冲绳空手在文化溯源的认同方面出现日本民间与中日两国学界的异化。从人类学角度观察,这一现象是国家在场的典型表现。研究通过海外民族志调查对空手核心参与者进行访谈,对现阶段国家在场影响冲绳空手文化认同进行探讨。研究发现日本的国家在场对冲绳空手的文化认同产生作用的表现集中在:以改革获取主导权;强化空手文化象征性;重塑空手文化和宣传空手文化等四个方面。归纳导致国家在场施加影响文化认同异化的关键因素集中在三个方面:(1)被激发的社会情绪波及空手文化认同;(2)决策失误导致冲绳经济下滑,引发行政干预;(3)国家在场异化影响空手群体的身份认同。研究最后指出,冲绳空手文化认同转向提醒我们,应进一步提升文化软实力,强化中华优秀传统体育话语的对外传播能力,加快推进中华民族现代文明建设。 展开更多
关键词 国家在场 冲绳空手 文化认同 海外民族志
在线阅读 下载PDF
耐心资本与体育企业韧性——基于一个倒U型模型的实证检验
20
作者 谭宏 刘青 《武汉体育学院学报》 北大核心 2026年第3期42-53,共12页
耐心资本在体育企业韧性塑造中具有延迟收益、维持稳态与支撑创新的独特功能。基于2015-2023年中国A股体育上市企业数据,运用面板回归与非线性模型,系统探讨耐心资本对体育企业韧性的影响特征及其管理层长期认知的作用机制,并考察国家... 耐心资本在体育企业韧性塑造中具有延迟收益、维持稳态与支撑创新的独特功能。基于2015-2023年中国A股体育上市企业数据,运用面板回归与非线性模型,系统探讨耐心资本对体育企业韧性的影响特征及其管理层长期认知的作用机制,并考察国家体育产业示范基地、大型体育赛事、全球公共卫生事件、国家体育消费试点城市与战略导向的情境调节效应。研究发现:(1)耐心资本与体育企业韧性呈显著倒U型关系,适度耐心资本可增强企业抗风险与创新能力,过量则导致资源沉淀与僵化;(2)机制分析表明,适度耐心资本通过强化管理层长期认知,提升企业战略稳健性与组织学习力,进而促进韧性提升;(3)调节效应检验表明,不同情境下耐心资本效应存在曲线位移:体育产业示范基地样本及大型体育赛事、全球公共卫生事件、国家体育消费试点城市样本中曲线右移;战略导向差异导致利润导向型与增长导向型企业拓宽了耐心资本的有效区间,增强了韧性。研究结论揭示了耐心资本在体育产业中影响企业韧性的非线性规律,为优化资本结构、强化管理认知与增强抗风险能力提供了实证支撑与政策启示。 展开更多
关键词 体育企业韧性 耐心资本 管理层认知 倒U型模型
在线阅读 下载PDF
上一页 1 2 250 下一页 到第
使用帮助 返回顶部