BACKGROUND:Renal metastases of hepatocellular carcinoma(HCC) are very rare.To our knowledge only five cases have been reported to the present;all had a well-known primary HCC.METHODS:We describe the clinico-pathologic...BACKGROUND:Renal metastases of hepatocellular carcinoma(HCC) are very rare.To our knowledge only five cases have been reported to the present;all had a well-known primary HCC.METHODS:We describe the clinico-pathological features of a rare case of HCC metastatic to the kidney in which the renal mass was the clinical debut of disease.The patient was a 54-year-old woman previously submitted to orthotopic liver transplantation,who underwent left nephrectomy for a renal mass.RESULTS:Histologically,the tumor was composed mainly of epithelioid cells with homogeneous acidophilic cytoplasm resembling oncocytoma or primary renal carcinoma with oncocytic features.A correct diagnosis was made on the basis of positive immunostaining for hepatocyte paraffin 1.CONCLUSIONS:Metastasis to the kidney is a rare complication that should be considered whenever a renal mass is present in patients with HCC.Since HCC may histologically resemble primary renal tumors such as oncocytoma,pathologists must be aware of this possibility above all in patients referred for liver transplantation and treated with immunosuppressant drugs.Immunohistochemistry is particularly helpful to establish a precise diagnosis in cases of doubt.展开更多
Background:Pulmonary hamartoma(PH)is the most common benign pulmonary tumor usually presenting as a solitary,well-demarcated nodule composed of mature cartilage and adipose tissue.Some unusual histologic variants are ...Background:Pulmonary hamartoma(PH)is the most common benign pulmonary tumor usually presenting as a solitary,well-demarcated nodule composed of mature cartilage and adipose tissue.Some unusual histologic variants are challenging on clinic-radiologic and pathologic examination.Methods:We collected a multicentric,retrospective,consecutive series of 206 PH with clinical characteristics and histologic variants.Results:Clinical data were in line with the literature demonstrating a male prevalence(2:1)and a median age of 61.6 years.The median size of the nodule was 17.8 mm.When performed,SUVmax>2.5 at FDC-PET was evidenced in 4%of cases(5 out of 119)and was significantly associated with undifferentiated/myxoid histology.Conventional histology showing chondroid or chondro-lipomatous PH was quoted in 186 cases(90%),while leiomyomatous and undifferentiated/myxoid variants were recorded in 20 cases(10%).The high rate of unusual variants on pathology is possibly related to a selection bias due to external consultations or surgical excision of the lesions lacking classic features at imaging studies.Conclusions:About 10% of PH may show unusual histology and SUVmax>2.5 at FDC-PET in 4%.These uncommon findings may challenge the correct recognition,raising some concerns in terms of differential diagnosis with several other mesenchymal tumors in the lung.These features should be kept in mind to achieve a correct diagnosis and avoid unnecessary invasive treatments.展开更多
文摘BACKGROUND:Renal metastases of hepatocellular carcinoma(HCC) are very rare.To our knowledge only five cases have been reported to the present;all had a well-known primary HCC.METHODS:We describe the clinico-pathological features of a rare case of HCC metastatic to the kidney in which the renal mass was the clinical debut of disease.The patient was a 54-year-old woman previously submitted to orthotopic liver transplantation,who underwent left nephrectomy for a renal mass.RESULTS:Histologically,the tumor was composed mainly of epithelioid cells with homogeneous acidophilic cytoplasm resembling oncocytoma or primary renal carcinoma with oncocytic features.A correct diagnosis was made on the basis of positive immunostaining for hepatocyte paraffin 1.CONCLUSIONS:Metastasis to the kidney is a rare complication that should be considered whenever a renal mass is present in patients with HCC.Since HCC may histologically resemble primary renal tumors such as oncocytoma,pathologists must be aware of this possibility above all in patients referred for liver transplantation and treated with immunosuppressant drugs.Immunohistochemistry is particularly helpful to establish a precise diagnosis in cases of doubt.
文摘Background:Pulmonary hamartoma(PH)is the most common benign pulmonary tumor usually presenting as a solitary,well-demarcated nodule composed of mature cartilage and adipose tissue.Some unusual histologic variants are challenging on clinic-radiologic and pathologic examination.Methods:We collected a multicentric,retrospective,consecutive series of 206 PH with clinical characteristics and histologic variants.Results:Clinical data were in line with the literature demonstrating a male prevalence(2:1)and a median age of 61.6 years.The median size of the nodule was 17.8 mm.When performed,SUVmax>2.5 at FDC-PET was evidenced in 4%of cases(5 out of 119)and was significantly associated with undifferentiated/myxoid histology.Conventional histology showing chondroid or chondro-lipomatous PH was quoted in 186 cases(90%),while leiomyomatous and undifferentiated/myxoid variants were recorded in 20 cases(10%).The high rate of unusual variants on pathology is possibly related to a selection bias due to external consultations or surgical excision of the lesions lacking classic features at imaging studies.Conclusions:About 10% of PH may show unusual histology and SUVmax>2.5 at FDC-PET in 4%.These uncommon findings may challenge the correct recognition,raising some concerns in terms of differential diagnosis with several other mesenchymal tumors in the lung.These features should be kept in mind to achieve a correct diagnosis and avoid unnecessary invasive treatments.
