Motor imagery is defined as an act wherein an individual contemplates a mental action of motor execution without apparent action.Mental practice executed by repetitive motor imagery can improve motor performance witho...Motor imagery is defined as an act wherein an individual contemplates a mental action of motor execution without apparent action.Mental practice executed by repetitive motor imagery can improve motor performance without simultaneous sensory input or overt output.We aimed to investigate cerebral hemodynamics during motor imagery and motor execution of a self-feeding activity using chopsticks.This study included 21 healthy right-handed volunteers.The self-feeding activity task comprised either motor imagery or motor execution of eating sliced cucumber pickles with chopsticks to examine eight regions of interest:pre-supplementary motor area,supplementary motor area,bilateral prefrontal cortex,premotor area,and sensorimotor cortex.The mean oxyhemoglobin levels were detected using near-infrared spectroscopy to reflect cerebral activation.The mean oxyhemoglobin levels during motor execution were significantly higher in the left sensorimotor cortex than in the supplementary motor area and the left premotor area.Moreover,significantly higher oxyhemoglobin levels were detected in the supplementary motor area and the left premotor area during motor imagery,compared to motor execution.Supplementary motor area and premotor area had important roles in the motor imagery of self-feeding activity.Moreover,the activation levels of the supplementary motor area and the premotor area during motor execution and motor imagery are likely affected by intentional cognitive processes.Levels of cerebral activation differed in some areas during motor execution and motor imagery of a self-feeding activity.This study was approved by the Ethical Review Committee of Nagasaki University(approval No.18110801)on December 10,2018.展开更多
Introduction: Child malnutrition is a major public health problem in Côte d’Ivoire in sub-Saharan Africa. This study aimed to determine the prevalence and factors influencing malnutrition in children under five ...Introduction: Child malnutrition is a major public health problem in Côte d’Ivoire in sub-Saharan Africa. This study aimed to determine the prevalence and factors influencing malnutrition in children under five in the peri-urban area of Abidjan, the economic capital. Patients and Methods: We carried out a prospective cross-sectional analytical study from May 3rd to October 31st 2019 at the General Hospital of Yopougon Attié in a peri-urban district of Abidjan, the economic capital. The study included 522 children aged 0 to 59 months who were received for a consultation, with the informed consent of their parents. The assessment of nutritional status was based on WHO growth standards. Statistical comparisons were made using the Chi-2 test for a significant p-value below 5%. Results: The population was predominantly female (sex ratio of 0.91) with an average age of 8.21 months and overall modest socio-economic conditions. The prevalence of malnutrition was as follows: 3.45% of malnutrition by excess, including 0.57% of obesity, 16.09% of stunting (5.75% severe), 12.07% of underweight (3.45% severe), 8.04% emaciation (1.91% severe). Three risk factors were identified for default malnutrition: age less than 6 months (p = 0.022), low birth weight (p = 0.003), and prematurity (p Conclusion: Malnutrition by deficiency is common in peri-urban areas in Abidjan with the main risk factors being age less than 6 months, low birth weight and prematurity. Fighting against those risk factors could help improve the nutritional status of children under five in the peri-urban environment of Abidjan.展开更多
Background:Exercise training protects against heart failure.However,the mechanism underlying the protective effect of exercise training on angiotensinⅡ(AngⅡ)-induced cardiac fibrosis remains unclear.Methods:An exerc...Background:Exercise training protects against heart failure.However,the mechanism underlying the protective effect of exercise training on angiotensinⅡ(AngⅡ)-induced cardiac fibrosis remains unclear.Methods:An exercise model involving C57BL/6N mice and 6 weeks of treadmill training was used.AngⅡ(1.44 mg/kg/day)was administered to induce cardiac fibrosis.RNA sequencing and bioinformatic analysis were used to identify the key factors mediating the effects of exercise training on cardiac fibrosis.Primary adult mouse cardiac fibroblasts(CFs)were used in vitro.Adeno-associated virus serotype 9 was used to overexpress POU domain,class 2,transcription factor 1(POU2F1)in vivo.Results:Exercise training attenuated AngⅡ-induced cardiac fibrosis and reversed 39 gene expression changes.The transcription factor regulating the largest number of these genes was POU2F1.Compared to controls,POU2F1 was shown to be signififcantly upregulated by AngⅡ,which is itself reduced by exercise training.In vivo,POU2F1 overexpression nullified the benefits of exercise training on cardiac fibrosis.In CFs,POU2F1 promoted cardiac fibrosis.CCAAT enhancer-binding proteinβ(C/EBPβ)was predicted to be the transcription factor of POU2F1and verified using a dual-luciferase reporter assay.In vivo,exercise training activated AMP-activated protein kinase(AMPK)and alleviated the increase in C/EBPβinduced by AngⅡ.In CFs,AMPK agonist inhibited the increase in C/EBPβand POU2F1 induced by Ang II,whereas AMPK inhibitor reversed this effect.Conclusion:Exercise training attenuates AngⅡ-induced cardiac fibrosis by reducing POU2F1.Exercise training inhibits POU2F1 by activating AMPK,which is followed by the downregulation of C/EBPβ,the transcription factor of POU2F1.展开更多
With recent progress in low-density lipoprotein cholesterol(LDL-C)management,the cornerstone of cardiovascular disease(CVD)prevention,residual cardiovascular risk remains[1].Lipoprotein(a)[Lp(a)]and inflammation are b...With recent progress in low-density lipoprotein cholesterol(LDL-C)management,the cornerstone of cardiovascular disease(CVD)prevention,residual cardiovascular risk remains[1].Lipoprotein(a)[Lp(a)]and inflammation are both listed as leading residual risk factors for CVD.Circulating levels of Lp(a)are primarily determined by genetics[2].Previous study demonstrated that elevated Lp(a)contributed to residual cardiovascular risk across all levels of LDL-C,and that LDL-C lowering did not fully offset Lp(a)-mediated risk[3,4].Additionally,interleukin-6(IL-6).展开更多
Aortic aneurysm is a chronic aortic disease affected by many factors.Although it is generally asymptomatic,it poses a significant threat to human life due to a high risk of rupture.Because of its strong concealment,it...Aortic aneurysm is a chronic aortic disease affected by many factors.Although it is generally asymptomatic,it poses a significant threat to human life due to a high risk of rupture.Because of its strong concealment,it is difficult to diagnose the disease in the early stage.At present,there are no effective drugs for the treatment of aneurysms.Surgical intervention and endovascular treatment are the only therapies.Although current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm,the specific mechanisms remain unclear.Researchers are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and treatment.To better understand aortic aneurysm,this review elaborates on the discovery history of aortic aneurysm,main classification and clinical manifestations,related molecular mechanisms,clinical cohort studies and animal models,with the ultimate goal of providing insights into the treatment of this devastating disease.The underlying problem with aneurysm disease is weakening of the aortic wall,leading to progressive dilation.If not treated in time,the aortic aneurysm eventually ruptures.An aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic wall.The disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.展开更多
Summary What is already known about this topic?Rehabilitation is an essential part of achieving health for all,whereas the estimates of rehabilitation needs,especially for elderly individuals in China,are not clear.Wh...Summary What is already known about this topic?Rehabilitation is an essential part of achieving health for all,whereas the estimates of rehabilitation needs,especially for elderly individuals in China,are not clear.What is added by this report?Compared with 1990,the prevalence and years of life lived with disability for health conditions in need of rehabilitation in China increased by 71.3%and 77.0%in 2019,respectively,at a rate much higher than the global average.What are the implications for public health practices?This study mainly presents scientific data and a systematic analysis of the current state and challenges of rehabilitation needs for elderly individuals(aged 60 and above)in China based on the World Health Organization Rehabilitation Need Estimator.展开更多
Background Posterior lumbar arthrodesis has become a widely used therapeutic option to correct sagittal imbalances in patients suffering from degenerative lumbar conditions.However,in western Africa,there is no study ...Background Posterior lumbar arthrodesis has become a widely used therapeutic option to correct sagittal imbalances in patients suffering from degenerative lumbar conditions.However,in western Africa,there is no study have reported long-term outcome of posterior lumbar arthrodesis.The aim of this study was to investigate the relationship between the restoration of adequate lordosis and the patient’s postoperative quality of life.Method The study was retrospective.From January 2012 to December 2019,80 patients who underwent posterior lumbar arthrodesis for lumbar degenerative diseases were included with a mean follow-up of 43.2 months.Mean age was 50.8 years(SD=12.2).Preoperative and postoperative patients'symptoms were assessed by the visual analog scale(VAS),Oswestry Disability Index(ODI),and 12-item Short Form(SF-12).Pre-and post-operative radiographic evaluation included lumbar lordosis measured(LLm),pelvic incidence(PI),sacral slope(SS),and pelvic stilt(PS).Theoretical lumbar lordosis(LLt)was defined by the following:LL=0.54×PI+27.6.Data analysis was done using the statistical software"R."The risk of error was 5%(p<0.05).Result The mean pelvic incidence was 57.23°.There was no statistically significant difference between preoperative and postoperative lumbar lordosis(p=0.2567).There was no statistical difference between preoperative and post-operative PI-LL(p=0.179).There was a statistically significant difference between the pre and postoperative clinical scores(p<0.001).Statistical analysis showed a correlation between recovery of lumbar lordosis and improvement in physical component of SF-12(PCS)(p<0.05)and lumbar and radicular VAS(p<0.05)for the subgroup of narrow lumbar spine.There was a statistical relationship between the restoration of lumbar lordosis and improvement in PCS(p=0.004)and VAS(p=0.003)for the subgroup of isthmic lysis spondylolisthesis.Discussion The root decompression performed in most patients could explain the clinical improvement regardless of recovery of lordosis.The failure to consider spinal parameters and sagittal balance of patients in the surgery could explain no restoration of lumbar lordosis.Our study had limitations inherent to its retrospective character such as the classic selection bias.Conclusion Satisfactory correction of spinopelvic alignment may improve long-term clinical signs.展开更多
Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and p...Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and pathogenesis.The immature phenotypes of stem cell-differentiated cells deposit a major bottleneck in regenerative medicine.展开更多
Rehabilitation is described as interventions that aim to optimize functioning and reduce disability in individuals with health conditions,considering their environment[1].Global estimates of rehabilitation needs revea...Rehabilitation is described as interventions that aim to optimize functioning and reduce disability in individuals with health conditions,considering their environment[1].Global estimates of rehabilitation needs revealed that about one-third of the world's population could potentially benefit from rehabilitation in 2019,making a substantial 69%increase in years lived with disability(YLDs)since 1990[2].With the expanding global population,aging demographics,and shifts in health trends,the health burden of functional recovery is experiencing a significant escalation[3].展开更多
Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been ...Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult.展开更多
Cardiac fibrosis is the excessive deposition of extracellular matrix(ECM)proteins in heart tissues leading to functional and electrophysiological abnormalities.Being a common pathology in different diseased conditions...Cardiac fibrosis is the excessive deposition of extracellular matrix(ECM)proteins in heart tissues leading to functional and electrophysiological abnormalities.Being a common pathology in different diseased conditions,cardiac fibrosis has been regarded as an appropriate(reparative)or inappropriate(reactive)pathological response.展开更多
Obesity is a global issue that warrants the identification of more effective therapeutic targets and a better understanding of the pivotal molecular pathogenesis.Annexin A1(ANXA1)is known to inhibit phospholipase A2,e...Obesity is a global issue that warrants the identification of more effective therapeutic targets and a better understanding of the pivotal molecular pathogenesis.Annexin A1(ANXA1)is known to inhibit phospholipase A2,exhibiting anti-inflammatory activity.However,the specific effects of ANXA1 in obesity and the underlying mechanisms of action remain unclear.Our study reveals that ANXA1 levels are elevated in the adipose tissue of individuals with obesity.Whole-body or adipocyte-specific ANXA1 deletion aggravates obesity and metabolic disorders.ANXA1 levels are higher in stromal vascular fractions(SVFs)than in mature adipocytes.Further investigation into the role of ANXA1 in SVFs reveals that ANXA1 overexpression induces lower numbers of mature adipocytes,while ANXA1-knockout SVFs exhibit the opposite effect.This suggests that ANXA1 plays an important role in adipogenesis.Mechanistically,ANXA1 competes with MYC binding protein 2(MYCBP2)for interaction with PDZ and LIM domain 7(PDLIM7).This exposes the MYCBP2-binding site,allowing it to bind more readily to the SMAD family member 4(SMAD4)and promoting its ubiquitination and degradation.SMAD4 degradation downregulates peroxisome proliferator-activated receptor gamma(PPARγ)transcription and reduces adipogenesis.Treatment with Ac2-26,an active peptide derived from ANXA1,inhibits both adipogenesis and obesity through the mechanism.In conclusion,the molecular mechanism of ANXA1 inhibiting adipogenesis was first uncovered in our study,which is a potential target for obesity prevention and treatment.展开更多
文摘Motor imagery is defined as an act wherein an individual contemplates a mental action of motor execution without apparent action.Mental practice executed by repetitive motor imagery can improve motor performance without simultaneous sensory input or overt output.We aimed to investigate cerebral hemodynamics during motor imagery and motor execution of a self-feeding activity using chopsticks.This study included 21 healthy right-handed volunteers.The self-feeding activity task comprised either motor imagery or motor execution of eating sliced cucumber pickles with chopsticks to examine eight regions of interest:pre-supplementary motor area,supplementary motor area,bilateral prefrontal cortex,premotor area,and sensorimotor cortex.The mean oxyhemoglobin levels were detected using near-infrared spectroscopy to reflect cerebral activation.The mean oxyhemoglobin levels during motor execution were significantly higher in the left sensorimotor cortex than in the supplementary motor area and the left premotor area.Moreover,significantly higher oxyhemoglobin levels were detected in the supplementary motor area and the left premotor area during motor imagery,compared to motor execution.Supplementary motor area and premotor area had important roles in the motor imagery of self-feeding activity.Moreover,the activation levels of the supplementary motor area and the premotor area during motor execution and motor imagery are likely affected by intentional cognitive processes.Levels of cerebral activation differed in some areas during motor execution and motor imagery of a self-feeding activity.This study was approved by the Ethical Review Committee of Nagasaki University(approval No.18110801)on December 10,2018.
文摘Introduction: Child malnutrition is a major public health problem in Côte d’Ivoire in sub-Saharan Africa. This study aimed to determine the prevalence and factors influencing malnutrition in children under five in the peri-urban area of Abidjan, the economic capital. Patients and Methods: We carried out a prospective cross-sectional analytical study from May 3rd to October 31st 2019 at the General Hospital of Yopougon Attié in a peri-urban district of Abidjan, the economic capital. The study included 522 children aged 0 to 59 months who were received for a consultation, with the informed consent of their parents. The assessment of nutritional status was based on WHO growth standards. Statistical comparisons were made using the Chi-2 test for a significant p-value below 5%. Results: The population was predominantly female (sex ratio of 0.91) with an average age of 8.21 months and overall modest socio-economic conditions. The prevalence of malnutrition was as follows: 3.45% of malnutrition by excess, including 0.57% of obesity, 16.09% of stunting (5.75% severe), 12.07% of underweight (3.45% severe), 8.04% emaciation (1.91% severe). Three risk factors were identified for default malnutrition: age less than 6 months (p = 0.022), low birth weight (p = 0.003), and prematurity (p Conclusion: Malnutrition by deficiency is common in peri-urban areas in Abidjan with the main risk factors being age less than 6 months, low birth weight and prematurity. Fighting against those risk factors could help improve the nutritional status of children under five in the peri-urban environment of Abidjan.
基金supported by the National Natural Science Foundation of China(82030072 to HX,81871850 to HY,81972149 to WG,and 81830009 to YZ)Beijing Natural Science Foundation(No.7212125 to HY)+2 种基金National Key R&D Program of China(Grant No.2020YFA0803800 to HY)the Key Clinical Projects of Peking University Third Hospital(BYSYZD2019022 to HX)Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(No.2021-I2M-5-003 to HX and YZ)。
文摘Background:Exercise training protects against heart failure.However,the mechanism underlying the protective effect of exercise training on angiotensinⅡ(AngⅡ)-induced cardiac fibrosis remains unclear.Methods:An exercise model involving C57BL/6N mice and 6 weeks of treadmill training was used.AngⅡ(1.44 mg/kg/day)was administered to induce cardiac fibrosis.RNA sequencing and bioinformatic analysis were used to identify the key factors mediating the effects of exercise training on cardiac fibrosis.Primary adult mouse cardiac fibroblasts(CFs)were used in vitro.Adeno-associated virus serotype 9 was used to overexpress POU domain,class 2,transcription factor 1(POU2F1)in vivo.Results:Exercise training attenuated AngⅡ-induced cardiac fibrosis and reversed 39 gene expression changes.The transcription factor regulating the largest number of these genes was POU2F1.Compared to controls,POU2F1 was shown to be signififcantly upregulated by AngⅡ,which is itself reduced by exercise training.In vivo,POU2F1 overexpression nullified the benefits of exercise training on cardiac fibrosis.In CFs,POU2F1 promoted cardiac fibrosis.CCAAT enhancer-binding proteinβ(C/EBPβ)was predicted to be the transcription factor of POU2F1and verified using a dual-luciferase reporter assay.In vivo,exercise training activated AMP-activated protein kinase(AMPK)and alleviated the increase in C/EBPβinduced by AngⅡ.In CFs,AMPK agonist inhibited the increase in C/EBPβand POU2F1 induced by Ang II,whereas AMPK inhibitor reversed this effect.Conclusion:Exercise training attenuates AngⅡ-induced cardiac fibrosis by reducing POU2F1.Exercise training inhibits POU2F1 by activating AMPK,which is followed by the downregulation of C/EBPβ,the transcription factor of POU2F1.
基金supported by the National Key Research and Development Program of China(2024YFC3606700 and 2024YFC3606703)the Natural Science Foundation of Beijing Municipality(7254444 and Z230017)+5 种基金the Beijing Nova Program(20230484275)the National Natural Science Foundation of China(82300291)the CAMS Innovation Fund for Medical Sciences(2021-I2M-5-003)the Beijing Excellent Clinical Research Program(BRWEP2024W014090203)the PKUTH Clinical Cohort Project(BYSYDL2022002)the Peking University Shi-Ji Jin-Yuan Medical Foundation(48014Y0243)。
文摘With recent progress in low-density lipoprotein cholesterol(LDL-C)management,the cornerstone of cardiovascular disease(CVD)prevention,residual cardiovascular risk remains[1].Lipoprotein(a)[Lp(a)]and inflammation are both listed as leading residual risk factors for CVD.Circulating levels of Lp(a)are primarily determined by genetics[2].Previous study demonstrated that elevated Lp(a)contributed to residual cardiovascular risk across all levels of LDL-C,and that LDL-C lowering did not fully offset Lp(a)-mediated risk[3,4].Additionally,interleukin-6(IL-6).
基金This work was supported by the National Natural Science Foundation of China(81970425)by the National High Technology Research and Development Program of China(2020YFA0803700),and by Hangzhou Qianjiang Distinguished Expert Project(Prof.Lemin Zheng).
文摘Aortic aneurysm is a chronic aortic disease affected by many factors.Although it is generally asymptomatic,it poses a significant threat to human life due to a high risk of rupture.Because of its strong concealment,it is difficult to diagnose the disease in the early stage.At present,there are no effective drugs for the treatment of aneurysms.Surgical intervention and endovascular treatment are the only therapies.Although current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm,the specific mechanisms remain unclear.Researchers are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and treatment.To better understand aortic aneurysm,this review elaborates on the discovery history of aortic aneurysm,main classification and clinical manifestations,related molecular mechanisms,clinical cohort studies and animal models,with the ultimate goal of providing insights into the treatment of this devastating disease.The underlying problem with aneurysm disease is weakening of the aortic wall,leading to progressive dilation.If not treated in time,the aortic aneurysm eventually ruptures.An aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic wall.The disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.
基金Supported by Chinese Academy of Engineering(No.2021-XY-15)National Natural Science Fundation of China(No.L2124021)+1 种基金CAMS Innovation Fund for Medical Sciences(No.2021-I2M-5-003)Haihe Laboratory of Cell Ecosystem Innovation Fund(No.HH22KYZX0047).
文摘Summary What is already known about this topic?Rehabilitation is an essential part of achieving health for all,whereas the estimates of rehabilitation needs,especially for elderly individuals in China,are not clear.What is added by this report?Compared with 1990,the prevalence and years of life lived with disability for health conditions in need of rehabilitation in China increased by 71.3%and 77.0%in 2019,respectively,at a rate much higher than the global average.What are the implications for public health practices?This study mainly presents scientific data and a systematic analysis of the current state and challenges of rehabilitation needs for elderly individuals(aged 60 and above)in China based on the World Health Organization Rehabilitation Need Estimator.
文摘Background Posterior lumbar arthrodesis has become a widely used therapeutic option to correct sagittal imbalances in patients suffering from degenerative lumbar conditions.However,in western Africa,there is no study have reported long-term outcome of posterior lumbar arthrodesis.The aim of this study was to investigate the relationship between the restoration of adequate lordosis and the patient’s postoperative quality of life.Method The study was retrospective.From January 2012 to December 2019,80 patients who underwent posterior lumbar arthrodesis for lumbar degenerative diseases were included with a mean follow-up of 43.2 months.Mean age was 50.8 years(SD=12.2).Preoperative and postoperative patients'symptoms were assessed by the visual analog scale(VAS),Oswestry Disability Index(ODI),and 12-item Short Form(SF-12).Pre-and post-operative radiographic evaluation included lumbar lordosis measured(LLm),pelvic incidence(PI),sacral slope(SS),and pelvic stilt(PS).Theoretical lumbar lordosis(LLt)was defined by the following:LL=0.54×PI+27.6.Data analysis was done using the statistical software"R."The risk of error was 5%(p<0.05).Result The mean pelvic incidence was 57.23°.There was no statistically significant difference between preoperative and postoperative lumbar lordosis(p=0.2567).There was no statistical difference between preoperative and post-operative PI-LL(p=0.179).There was a statistically significant difference between the pre and postoperative clinical scores(p<0.001).Statistical analysis showed a correlation between recovery of lumbar lordosis and improvement in physical component of SF-12(PCS)(p<0.05)and lumbar and radicular VAS(p<0.05)for the subgroup of narrow lumbar spine.There was a statistical relationship between the restoration of lumbar lordosis and improvement in PCS(p=0.004)and VAS(p=0.003)for the subgroup of isthmic lysis spondylolisthesis.Discussion The root decompression performed in most patients could explain the clinical improvement regardless of recovery of lordosis.The failure to consider spinal parameters and sagittal balance of patients in the surgery could explain no restoration of lumbar lordosis.Our study had limitations inherent to its retrospective character such as the classic selection bias.Conclusion Satisfactory correction of spinopelvic alignment may improve long-term clinical signs.
基金supported by the National Key Research and Development Program of China (2022YFA1104800)the National Natural Science Foundation of China (82222006,32100660,82170367)+5 种基金Beijing Nova Program (Z211100002121003,20220484205)Beijing Natural Science Foundation (7232094)supported by National Institute of Health (R01HL146634 and UM1HL098166)supported by the Natural Science Foundation of China (82070235 and 92168113)the CAMS Innovation Fund for Medical Sciences (2021-I2M-5003)Haihe Laboratory of Cell Ecosystem Innovation Fund (HH22KYZX0047)。
文摘Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and pathogenesis.The immature phenotypes of stem cell-differentiated cells deposit a major bottleneck in regenerative medicine.
基金supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project(2023ZD0509601)National Natural Science Foundation of China(L2324221 and 82202820)+1 种基金CAMS Innovation Fund for Medical Sciences(2021-I2M-5-003)Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00007)。
文摘Rehabilitation is described as interventions that aim to optimize functioning and reduce disability in individuals with health conditions,considering their environment[1].Global estimates of rehabilitation needs revealed that about one-third of the world's population could potentially benefit from rehabilitation in 2019,making a substantial 69%increase in years lived with disability(YLDs)since 1990[2].With the expanding global population,aging demographics,and shifts in health trends,the health burden of functional recovery is experiencing a significant escalation[3].
基金supported by the National Key R&D Program of China (2021YFF0501401)the National Natural Science Foundation of China (82030072)+5 种基金the Michigan Medicine-PKUHSC Joint Institute for Translational and Clinical Research (BMU2019JI007)the Fundamental Research Funds for the Central Universitiesthe National Natural Science Foundation of China (81830009, 81822003)the Beijing Municipal Natural Science Foundation (7191013)the Key Clinical Projects of Peking University Third Hospital (BYSYZD2019022)CAMS Innovation Fund for Medical Sciences to (2021-I2M-5-003)。
文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult.
基金supported by the National Key R&D Program(2021YFF0501401 and 2021YFF0501400)the National Natural Science Foundation of China(82070393)+2 种基金the CAMS Innovation Fund for Medical Sciences(2021-I2M-5-003)the“Tianchi Talent”programthe Key Clinical Projects of Peking University Third Hospital(BYSYZD2019022)。
文摘Cardiac fibrosis is the excessive deposition of extracellular matrix(ECM)proteins in heart tissues leading to functional and electrophysiological abnormalities.Being a common pathology in different diseased conditions,cardiac fibrosis has been regarded as an appropriate(reparative)or inappropriate(reactive)pathological response.
基金supported by the National High Technology Research and Development Program of China(Grant NO.2020YFA0803700,NO.2023YFA1800904)the Natural Science Foundation of Beijing,China(Grant NO.L232031,NO.J230039)+4 种基金the Natural Science Foundation of China(Grant NO.81970425,NO.32171174,NO.U22A20286,NO.82270358)the Joint Funds from Guangzhou Science and Technology Project(Grant NO.2023A03J0531,NO.2024A03J0658)the Guangzhou Key Discipline of Medicine(Grant NO.ZDXK202103)(Geriatric Medicine,2021-2023)the Key Open Project of Metabolic Vascular Disease Key Laboratory of Sichuan Province(Grant NO.2022MVDKL-K1)the Guangzhou Municipal Science and Technology Project(2023A04J1265).
文摘Obesity is a global issue that warrants the identification of more effective therapeutic targets and a better understanding of the pivotal molecular pathogenesis.Annexin A1(ANXA1)is known to inhibit phospholipase A2,exhibiting anti-inflammatory activity.However,the specific effects of ANXA1 in obesity and the underlying mechanisms of action remain unclear.Our study reveals that ANXA1 levels are elevated in the adipose tissue of individuals with obesity.Whole-body or adipocyte-specific ANXA1 deletion aggravates obesity and metabolic disorders.ANXA1 levels are higher in stromal vascular fractions(SVFs)than in mature adipocytes.Further investigation into the role of ANXA1 in SVFs reveals that ANXA1 overexpression induces lower numbers of mature adipocytes,while ANXA1-knockout SVFs exhibit the opposite effect.This suggests that ANXA1 plays an important role in adipogenesis.Mechanistically,ANXA1 competes with MYC binding protein 2(MYCBP2)for interaction with PDZ and LIM domain 7(PDLIM7).This exposes the MYCBP2-binding site,allowing it to bind more readily to the SMAD family member 4(SMAD4)and promoting its ubiquitination and degradation.SMAD4 degradation downregulates peroxisome proliferator-activated receptor gamma(PPARγ)transcription and reduces adipogenesis.Treatment with Ac2-26,an active peptide derived from ANXA1,inhibits both adipogenesis and obesity through the mechanism.In conclusion,the molecular mechanism of ANXA1 inhibiting adipogenesis was first uncovered in our study,which is a potential target for obesity prevention and treatment.
