Background:Improving medication safety,particularly for high-risk drugs,was identified as the third Global Patient Safety Challenge by the World Health Organization in 2017.Antineoplastic agents are included in the li...Background:Improving medication safety,particularly for high-risk drugs,was identified as the third Global Patient Safety Challenge by the World Health Organization in 2017.Antineoplastic agents are included in the list of high-risk medications because of their high potential to cause adverse events.This study evaluated the effectiveness of a project that was implemented to improve the antineoplastic therapy compounding process at a university hospital.Methods:This study had a quasi-experimental before-and-after design and used a quantitative approach to investigate the effects of implementation of this project in a centralized intravenous admixture service.The compounding of antineoplastic therapy was evaluated using five quality criteria at three time points:an initial evaluation and two post-intervention re-evaluations.The results of the intervention were subjected to statistical analysis and are presented in a Pareto chart.Results:All five quality criteria for correct compounding of antineoplastic therapy improved after implementation of the intervention,with an increase in compliance values for all criteria after the second evaluation.Improvements in criteria 1,3,and 4 were statistically significant.Conclusions:The implementation of the improvement project enhanced the quality criteria and caused a cultural shift in the team,with an improved view towards quality management in work processes.展开更多
Finger-joint lumber is a sustainable building product commercialized as a structural solution for beams,pillars and other thin flat load-bearing elements.This study aims to study finger-joint lumber and its industry t...Finger-joint lumber is a sustainable building product commercialized as a structural solution for beams,pillars and other thin flat load-bearing elements.This study aims to study finger-joint lumber and its industry to promote this engineered wood product.The first research stage assessed the collection of publications on fingerjoint lumber available globally,in which a structured protocol was developed to prospect studies based on two complementary methodologies:PRISMA 2020 using Scopus and Web of Science databases,and Snowball using both forward and backward models to complete with additional literature.The second research stage assessed finger-joint lumber manufacturers,in which companies were globally prospected using Google search engine and their corporate websites were profoundly analyzed using a structured script to collect information.Literary approaches have provided structural performance and bonding quality of finger-jointing.In the review,we provide a global overview and data regarding the current stage and future directions of finger-joint lumber for industrialized construction.Regarding this structural product,we review the main resources,material preparation and processing,and automated production.Mainly active in Europe and already present in 38 nations across five continents,we survey a finger-joint lumber industry comprising 186 producers controlling 214 manufacturing operations worldwide.The vast majority of this industry has exported linear engineered solutions in different dimensions,certified as to compliance with the origins of their bioresources and the European Union requirements,to markets exposed to 24 languages in order to meet commercial applications such as single-story houses,townhouses,roof structures,and hangars.展开更多
Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that m...Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network.展开更多
The current study uses a longitudinal, mixed-method approach to investigate the role that new media, such as social networking sites and video chat, play in cross-cultural adaptation and international student friendsh...The current study uses a longitudinal, mixed-method approach to investigate the role that new media, such as social networking sites and video chat, play in cross-cultural adaptation and international student friendship network development. Results indicate that international students significantly increase and adapt their new media use while abroad to communicate globally with their friends and family, and locally with their newly formed relationships. Furthermore, social networking site host national friends do not necessarily lead to the development of face-to-face host national friends;however, interaction with established face-to-face host national friends and friend groups via new media platforms leads to an increased understanding of host communication patterns. Finally, this study proposes that researchers who apply Kim’s [1] cross-cultural adaptation theory consider incorporating Host New Media Communication as a principal concept.展开更多
Many tumors are unique to the organs from which they arise. Over the last 20 years, however, most tumors that were thought to be primary in soft tissues (derived from the primitive mesenchyme) and thought not to have ...Many tumors are unique to the organs from which they arise. Over the last 20 years, however, most tumors that were thought to be primary in soft tissues (derived from the primitive mesenchyme) and thought not to have counterparts in bone, were found to, in fact, rarely arise as unique lesions from bone. Some examples include synovial sarcoma, rhabdomyosarcoma and leiomyosarcoma, to name but three. We now have begun to see the reverse with lesions that were initially thought to be unique to bone arising in soft tissue. While this has been well reported with osteosarcoma and Ewing's sarcoma, it has never been reported with Bizarre Parosteal Osteochondromatous Proliferation (BPOP), also known as Nora's lesion. This study explores the first reported case of a soft tissue lesion, with clinical, radiological and histopathological characteristics of BPOP.展开更多
Objective: Understanding the perception of women who have recently given birth in a Brazilian hospital regarding labor pain and nursing involvement in the labor process. Methodology: exploratory, descriptive and quali...Objective: Understanding the perception of women who have recently given birth in a Brazilian hospital regarding labor pain and nursing involvement in the labor process. Methodology: exploratory, descriptive and qualitative study carried out in a Maternity part of the supplementary health system in the Federal District (DF). Data were collected between May and July 2015 through interviews using a semi-structured questionnaire. The sample consisted of 16 mothers and data analysis followed Bardin methodology in three phases. Results: The pain experienced during labor is surrounded by feelings and expectations. Both positive and negative feelings experienced by mothers were identified in the interviews and unanimous opinion was the fact that the second stage is the most painful period as continuous pain is experienced. Some of the participants compared pain with strong menstrual cramps, renal colic and back pain;others, said labor pain was the strongest ever experienced. The immediate contact with the newborn was referred to as a reward for coping with breast pain and suffering. Other factors such as the importance of follow-up, support and coping with the pain and care provided by health staff were also highlighted. Conclusion: empowerment of the mother and family through knowledge is considered an important tool to fight pain and cope with the birth process in a positive and physiological way, which in the long run promotes a cultural change in the population regarding the importance of vaginal birth.展开更多
The increasing demand for energy has intensified recently, requiring alternative sources to fossil fuels, which have become economically and environmentally unfeasible. On the other hand, the increasing land occupatio...The increasing demand for energy has intensified recently, requiring alternative sources to fossil fuels, which have become economically and environmentally unfeasible. On the other hand, the increasing land occupation in recent centuries is a growing problem, demanding greater efficiency, particularly in the reuse of abandoned areas, which has become an alternative. An interesting alternative would be installing energy facilities like solar, wind, biomass, and geothermal, in these areas. The objective of this paper is to develop a classification methodology, based on Artificial Intelligence (AI) and Quantum Theory (QT), to automatically carry out the classification of abandoned areas suitable for the settlement of these power plants. Artificial Neural Networks (ANNs) improved by the hybrid algorithm Quantum-behaved Particle Swarm Optimization (QPSO) together with the Levenberg-Marquardt Algorithm (LMA) were used for the classification task. In terms of Mean Squared Error (MSE), the QPSO-LMA approach achieved a decrease of 19.6% in relation to the classical LMA training with random initial weights. Moreover, the model’s accuracy showed an increase of 7.3% for the QPSO-LMA over the LMA. To validate this new approach, it was also tested on six different datasets available in the UCI Machine Learning Repository and seven classical techniques established in the literature. For the problem of installing photovoltaic plants in abandoned areas, the knowledge acquired with the solar dataset can be extrapolated to other regions.展开更多
Magnetite (Fe<sub>3</sub>O<sub>4</sub>) crystals have been synthesized from the natural iron sands of Tegal Lenga Beach with HCl (37%) as a solvent. Tegal Lenga Beach is a stretch of beach loca...Magnetite (Fe<sub>3</sub>O<sub>4</sub>) crystals have been synthesized from the natural iron sands of Tegal Lenga Beach with HCl (37%) as a solvent. Tegal Lenga Beach is a stretch of beach located in Kalisada Village, Seririt District, Buleleng Regency, Bali Province, Indonesia. Iron sand samples were obtained by extracting local natural sand from Tegal Lenga Beach by magnetic separation method. The iron sand sample was ground with agate mortar for 15 hours, then washed and rinsed with deionized water (DI water). Furthermore, the fine powder sample of iron sand was dried on a hotplate at a temperature of 80˚C until all the water had evaporated. Eighty grams of fine iron sand powder dissolved in 200 mL HCl (37%) while stirring with a hot plate magnetic stirrer at a temperature of 100˚C with a rotating speed of 600 rpm for 30 minutes. This solution was filtered through Wattman filter paper No. 42;then the filtrate was dried using a hot plate at a temperature of 100˚C to form a crust. This crust is then ground in an agate mortar until it becomes a fine powder of iron sand. Furthermore, the iron sand fine powder filtrate sample was divided into four equal parts which were then calcined at temperatures of 300˚C, 400˚C, 450˚C, and 500˚C for 30 minutes, respectively. It was found that the fine powder of iron sand from the natural sand of the Tegal Lenga Beach consisted mostly of 84.26% metal oxide magnetite. The synthesized magnetite crystal has a tetrahedral structure with lattice parameters of a = b = (5.927 ± 0.0180) Åand c = (16.774 ± 0.0145) Å. Magnetite crystals have granular and lumpy grains with an average grain size of (94,560 ± 10,1397) μm. In relation to the values obtained from the hysteresis curve, namely the remanent magnetization of 9.6672 emu/gr, saturation magnetization of 45.3491 emu/gr, coercive magnetic field strength of 0.0242 T, and saturation magnetic field strength of 0, 2938 T, then this magnetite crystal is classified as a weak ferromagnetic material.展开更多
Objective:The aim of this research is to explore the life experiences of schizophrenic families in accompanying the recovery process.Methods:This study uses a qualitative method with descriptive phenomenology to expla...Objective:The aim of this research is to explore the life experiences of schizophrenic families in accompanying the recovery process.Methods:This study uses a qualitative method with descriptive phenomenology to explain phenomena from family experiences.The number of the participants was eight families who had family members with schizophrenia.Sampling was determined by purposive sampling.Data were collected through in-depth interviews and analyzed using the Colaizzi method.Results:The results of this study show four themes that emerged including(1)psychological burden on the family,(2)families needing support in the recovery process,(3)obstacles due to social stigma,and(4)family gratitude for being able to pass the test patiently.Conclusion:The schizophrenia family’s journey in the recovery process is very long.They are required to endure in assisting the recovery process.Experiences felt by the family include feelings,obstacles,and hopes that arise in carrying out their role to assist the recovery process which aims to improve the health of schizophrenia patients.The findings from this study provide insight for nurses to be able to pay attention to family psychological problems by strengthening families through home visits and health promotion related to the recovery process of survivor schizophrenia.展开更多
Incorrect family behavior in caring for the dental and oral health of preschool-aged children can affect the incidence of dental caries in these children and can cause more serious health problems in the future if not...Incorrect family behavior in caring for the dental and oral health of preschool-aged children can affect the incidence of dental caries in these children and can cause more serious health problems in the future if not treated immediately,so it is important to find the right solution.This study aims to determine the effect of family counseling on dental and oral care for preschoolers.This study uses a narrative literature review method.Search articles using 5 databases(Pubmed,ScienceDirect,SpringerLink,ProQuest,and Google Scholar)to search for articles with the keywords family counseling AND Oral health AND Early Childhood Caries AND Behavior Change AND Family and the article selection process refers to the Flow diagram of the PRISMA Statement 2020.The results showed that there were 7 articles analyzed in this study.The implementation of family counseling has a significant effect in increasing self-efficacy,knowledge,ability,and motivation of the family,as well as the behavior of the child,to reduce the risk of dental caries in preschool-age children,taking into account several conditions.It was determined that family counseling is effective in reducing the incidence of dental caries in preschool children.展开更多
Background:Nowdays,both of parents are working to fulfill their family needs and family financial.However,this condition effected separation of family that have a negative impact for children.Children can lose of a pr...Background:Nowdays,both of parents are working to fulfill their family needs and family financial.However,this condition effected separation of family that have a negative impact for children.Children can lose of a primary caregiver who can endanger the welfare of children.Purpose:To analyzed the relationship between family separation and nutritional status of under-five children aged in Panti District of Jember Regency.Methods:A cross-sectional design was conducted among 53 families using total sampling.A family background questionnaire was used to measure sociodemographics and separation of family.Among 53 families were 78.2%of separation with father,while 38.6%of children with a good nutrition status.Kruskal Wallis and One-Way Anova was performed to answer the objective of this study.Results:The result showed that,there were no correlation between length of separation with nutritional status(F=0.377;P-value=0,688).Meanwhile,distance of separation wascorrelated with nutritional status(c2=8.310;P-value=0,016).Conclusion:Parents need to improve relationships,communication and the distribution of proper autonomy in family.It can make the nutritional status and health level of the child becomes better.展开更多
Background:Family is an essential element in caring for clients with hypertension.Appropriate hypertension management can reduce health risks during the treatment.Health coaching in family is a critical intervention t...Background:Family is an essential element in caring for clients with hypertension.Appropriate hypertension management can reduce health risks during the treatment.Health coaching in family is a critical intervention to control and manage hypertension through providing education,information,and skills intervention are needed to support lifestyle improvements,manage chronic conditions,and prevent complications of hypertension.This literature study describes health coaching for controlling blood pressure among clients with hypertension in the family.Methods:Narrative literature review was performed to select the article that relates to health coaching of hypertension in the family using search engines including PubMed,ProQuest,SpringerLink,ScienceDirect,and Google Scholar by using keywords health coaching,family,hypertension,and blood pressure.The analysis of articles was carried out using four stages based on the PRISMA flowchart diagram.Results:The results indicated eight articles that were analyzed in this study.Interactive health coaching interventions based on a healthy lifestyle carried out with patients and families effectively improve medication adherence and reduce systolic and diastolic blood pressure.Meanwhile,health coaching applied regarding the principles including motivation,discussion,interviews and goal setting to influence behavior change and self-management.Conclusions:That health coaching applied for families with clients with hypertension is effect on reducing blood pressure and other changes,including knowledge,self-efficacy,and behavior towards health services for patients with hypertension.Therefore,health coaching for the family could be used as a family intervention for clients with hypertension during home health care.展开更多
A review of coreflood experiments for chemically enhanced oil recovery(EOR)is presented in this paper,particularly surfactant-polymer(SP)and alkali-surfactant-polymer(ASP)processes.The objective of this review is to g...A review of coreflood experiments for chemically enhanced oil recovery(EOR)is presented in this paper,particularly surfactant-polymer(SP)and alkali-surfactant-polymer(ASP)processes.The objective of this review is to gain a general outlook and insight from coreflood experiments injecting SP or ASP slug as tertiary recovery.The discussion is separated into sections based on relevant core and fluid properties as well as surfactant selection and SP/ASP slug design and their impact on incremental recovery.Most studies in this review have been published within the last twenty years but few older coreflood works have been included for benchmarking.Parameters in each reviewed study have been summarized in tables to help readers gain detailed observation.Lessons learned from these past experiments should help other chemical EOR practitioners or students of the field in benchmarking or improving the outcomes of their future SP/ASP experiments.展开更多
Climate change is increasing the frequency of extreme heat events that aggravate its negative impact on plant development and agricultural yield.Most experiments designed to study plant adaption to heat stress apply h...Climate change is increasing the frequency of extreme heat events that aggravate its negative impact on plant development and agricultural yield.Most experiments designed to study plant adaption to heat stress apply homogeneous high temperatures to both shoot and root.However,this treatment does not mimic the conditions in natural fields,where roots grow in a dark environment with a descending temperature gradient.Excessively high temperatures severely decrease cell division in the root meristem,compromising root growth,while increasing the division of quiescent center cells,likely in an attempt to maintain the stem cell niche under such harsh conditions.Here,we engineered the TGRooZ,a device that generates a temperature gradient for in vitro or greenhouse growth assays.The root systems of plants exposed to high shoot temperatures but cultivated in theTGRooZ grow efficiently and maintain their functionality to sustain proper shoot growth and development.Furthermore,gene expression and rhizosphere or root microbiomecomposition are significantly less affected in TGRooZ-grown roots than in high-temperature-grown roots,correlating with higher root functionality.Our data indicate that use of the TGRooZ in heat-stress studies can improve our knowledge of plant response to high temperatures,demonstrating its applicability from laboratory studies to the field.展开更多
Tumor-associated macrophages （TAMs） play a critical role in melanoma growth and metastasis. Infiltration of TAMs correlates with the poor prognosis of melanoma. TAMs are differentiated from monocytes in response to ...Tumor-associated macrophages （TAMs） play a critical role in melanoma growth and metastasis. Infiltration of TAMs correlates with the poor prognosis of melanoma. TAMs are differentiated from monocytes in response to the tumor microenvironment cue. However, the mechanism how TAMs adapt to the tumor microenvironment after differentiation from monocytes is not fully understood. In addition, specific identification of TAMs in melanoma is difficult because the expression of the most commonly used macrophage marker, CD68, is also expressed in melanoma cells. In an earlier study, we found by gene microarray analysis that seven members of the metallothionein （MTs） family were upregulated in melanoma-conditioned medium induced macrophages （MCIM-MO）. MTs have been implicated in zinc metabolism and inflammation. In the present study, we confirmed that expression of metallothionein is induced in M-CSF differentiated macrophages （M-CSF/M~） and MCIM-M~ at both the mRNA and protein levels using real-time PCR, immunofluorescence, and western blot analysis. Furthermore, we demonstrated the presence of metallothionein in melanoma tissues in vivo and that metallothionein was co-localized with TAMs markers, CD68 and CD163. Finally, we demonstrated the induction of the zinc importer gene Zip8 both in M-CSF/MO and MCIM-MO. Our study identifies metallothionein as a novel marker for TAMs and suggests that metaliothionein might play important roles in macrophage adaptation and function in the tumor microenvironment.展开更多
Background:The concept of phase separation has been used to describe and interpret physicochemical phenomena in biological systems for decades.Many intracellular macromolecules undergo phase separation,where it plays ...Background:The concept of phase separation has been used to describe and interpret physicochemical phenomena in biological systems for decades.Many intracellular macromolecules undergo phase separation,where it plays important roles in gene regulation,cellular signaling,metabolic reactions and so on,due to its unique dynamic properties and biological effects.As the noticeable importance of phase separation,pioneer researchers have explored the possibility to introduce the synthetically engineered phase separation for applicable cell function.Results:In this article,we illustrated the application value of phase separation in synthetic biology.We described main states of phase separation in detail,summarized some ways to implement synthetic condensates and several methods to regulate phase separation,and provided a substantial amount of identical examples to illuminate the applications and perspectives of phase separation in synthetic biology.Conclusions:Multivalent interactions implement phase separation in synthetic biology.Small molecules,light control and spontaneous interactions induce and regulate phase separation.The synthetic condensates are widely used in signal amplifications,designer orthogonally non-membrane-bound organelles,metabolic pathways,gene regulations,signaling transductions and controllable platforms.Studies on quantitative analysis,more standardized modules and precise spatiotemporal control of synthetic phase separation may promote the further development of this field.展开更多
For interventional cardiologists, it is very challenging to do percutaneous coronary interventions （PCI） in lesions of ihe left main, bifilrcations or of chronic total occlusion types. However, it is more challengin...For interventional cardiologists, it is very challenging to do percutaneous coronary interventions （PCI） in lesions of ihe left main, bifilrcations or of chronic total occlusion types. However, it is more challenging to demonstrate an evidence based rationale supporting the indications of PCI in these lesions. In this article, new questions are raised on the benefits and the mechanism of benefits for PCI of bifilrcations revolving large side branches such as the diagonal （DIAG）,展开更多
Objective WHO recommends that every pregnant woman and newborn receive quality care throughout the pregnancy,delivery and postnatal periods.However,Maternal Mortality Ratio in Indonesia for 2015 reached 305 per 100000...Objective WHO recommends that every pregnant woman and newborn receive quality care throughout the pregnancy,delivery and postnatal periods.However,Maternal Mortality Ratio in Indonesia for 2015 reached 305 per 100000 live births,which exceeds the target of Sustainable Development Goals(<70 per 100000 live births).Receiving at least four times antenatal care(ANC4+)and skilled birth attendant(SBA)during childbirth is crucial for preventing maternal and neonatal deaths.The study aims to assess the determinants of ANC4+and SBA independently,evaluate the distribution of utilisation of ANC4+and SBA services,and further investigate the associations of two levels of continuity of services utilisation in Indonesia Design Data from the Indonesia Demographic and Health Survey,a cross-sectional and large-scale national survey conducted in 2017 were used.Setting This study was set in Indonesia.Participants The study involved ever-married women of reproductive age(15-49 years)and had given birth in the last 5 years prior to the survey(n=15288).The dependent variables are the use of ANC4+and SBA.Individual,family and community factors,such as age,age at first birth,level of education,employment status,parity,autonomy in healthcare decision-making,level of education,employment status of spouses,household income,mass media consumption residence and distance from health facilities were also measured.Results Results showed that 11632(76.1%)women received ANC4+and SBA during childbirth.Multivariate analysis revealed that age,age at first birth,and parity have a statistically significant association with continuity of services utilisation.The odds of using continuity of services were higher among women older than 34 years(adjusted OR(aOR)1.54;95%CI 1.31 to 1.80)compared with women aged 15-24 years.Women with a favourable distance from health facilities were more likely to receive continuity of services utilisation(aOR 1.39;95%CI 1.24 to 1.57).Conclusions The continuity of services utilisation is associated with age,reproductive status,family influence and accessibility-related factors.Findings demonstrated the importance of enhancing early reproductive health education for men and women.The health system reinforcement,community empowerment and multisectoral engagement enhance accessibility to health facilities,reduce financial and geographical barriers,and produce strong quality care.展开更多
文摘Background:Improving medication safety,particularly for high-risk drugs,was identified as the third Global Patient Safety Challenge by the World Health Organization in 2017.Antineoplastic agents are included in the list of high-risk medications because of their high potential to cause adverse events.This study evaluated the effectiveness of a project that was implemented to improve the antineoplastic therapy compounding process at a university hospital.Methods:This study had a quasi-experimental before-and-after design and used a quantitative approach to investigate the effects of implementation of this project in a centralized intravenous admixture service.The compounding of antineoplastic therapy was evaluated using five quality criteria at three time points:an initial evaluation and two post-intervention re-evaluations.The results of the intervention were subjected to statistical analysis and are presented in a Pareto chart.Results:All five quality criteria for correct compounding of antineoplastic therapy improved after implementation of the intervention,with an increase in compliance values for all criteria after the second evaluation.Improvements in criteria 1,3,and 4 were statistically significant.Conclusions:The implementation of the improvement project enhanced the quality criteria and caused a cultural shift in the team,with an improved view towards quality management in work processes.
基金supported by the Scientific Grant Agency of the Ministry of Education,Science,Research and Sport of the Slovak Republic(VEGA)with VEGA 1/0228/24 Project and the Cultural and Educational Grant Agency Ministry of Education,Science,Research and Sport of the Slovak Republic(KEGA)with KEGA 017TUKE-4/2024 ProjectBrazilian Federal Agency for Support and Evaluation of Graduate Education(CAPES),with finance code 001.
文摘Finger-joint lumber is a sustainable building product commercialized as a structural solution for beams,pillars and other thin flat load-bearing elements.This study aims to study finger-joint lumber and its industry to promote this engineered wood product.The first research stage assessed the collection of publications on fingerjoint lumber available globally,in which a structured protocol was developed to prospect studies based on two complementary methodologies:PRISMA 2020 using Scopus and Web of Science databases,and Snowball using both forward and backward models to complete with additional literature.The second research stage assessed finger-joint lumber manufacturers,in which companies were globally prospected using Google search engine and their corporate websites were profoundly analyzed using a structured script to collect information.Literary approaches have provided structural performance and bonding quality of finger-jointing.In the review,we provide a global overview and data regarding the current stage and future directions of finger-joint lumber for industrialized construction.Regarding this structural product,we review the main resources,material preparation and processing,and automated production.Mainly active in Europe and already present in 38 nations across five continents,we survey a finger-joint lumber industry comprising 186 producers controlling 214 manufacturing operations worldwide.The vast majority of this industry has exported linear engineered solutions in different dimensions,certified as to compliance with the origins of their bioresources and the European Union requirements,to markets exposed to 24 languages in order to meet commercial applications such as single-story houses,townhouses,roof structures,and hangars.
基金funded by the Pudong New Area Science and Technology Development Fund,China (J. Yang,#PKJ2014-Y08)Shanghai University of Medicine & Health Sciences Seed Foundation Project,China (J. Yang,#SPF-18-20-14-006)+2 种基金ational Natural Science Foundation of China (W. Shen,#31771169 and #91857104)Thousand Young Talents Program of China (W. Shen)ShanghaiTech University start-up fund (W. Shen)
文摘Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy homeostasis.Interestingly, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network.
文摘The current study uses a longitudinal, mixed-method approach to investigate the role that new media, such as social networking sites and video chat, play in cross-cultural adaptation and international student friendship network development. Results indicate that international students significantly increase and adapt their new media use while abroad to communicate globally with their friends and family, and locally with their newly formed relationships. Furthermore, social networking site host national friends do not necessarily lead to the development of face-to-face host national friends;however, interaction with established face-to-face host national friends and friend groups via new media platforms leads to an increased understanding of host communication patterns. Finally, this study proposes that researchers who apply Kim’s [1] cross-cultural adaptation theory consider incorporating Host New Media Communication as a principal concept.
文摘Many tumors are unique to the organs from which they arise. Over the last 20 years, however, most tumors that were thought to be primary in soft tissues (derived from the primitive mesenchyme) and thought not to have counterparts in bone, were found to, in fact, rarely arise as unique lesions from bone. Some examples include synovial sarcoma, rhabdomyosarcoma and leiomyosarcoma, to name but three. We now have begun to see the reverse with lesions that were initially thought to be unique to bone arising in soft tissue. While this has been well reported with osteosarcoma and Ewing's sarcoma, it has never been reported with Bizarre Parosteal Osteochondromatous Proliferation (BPOP), also known as Nora's lesion. This study explores the first reported case of a soft tissue lesion, with clinical, radiological and histopathological characteristics of BPOP.
文摘Objective: Understanding the perception of women who have recently given birth in a Brazilian hospital regarding labor pain and nursing involvement in the labor process. Methodology: exploratory, descriptive and qualitative study carried out in a Maternity part of the supplementary health system in the Federal District (DF). Data were collected between May and July 2015 through interviews using a semi-structured questionnaire. The sample consisted of 16 mothers and data analysis followed Bardin methodology in three phases. Results: The pain experienced during labor is surrounded by feelings and expectations. Both positive and negative feelings experienced by mothers were identified in the interviews and unanimous opinion was the fact that the second stage is the most painful period as continuous pain is experienced. Some of the participants compared pain with strong menstrual cramps, renal colic and back pain;others, said labor pain was the strongest ever experienced. The immediate contact with the newborn was referred to as a reward for coping with breast pain and suffering. Other factors such as the importance of follow-up, support and coping with the pain and care provided by health staff were also highlighted. Conclusion: empowerment of the mother and family through knowledge is considered an important tool to fight pain and cope with the birth process in a positive and physiological way, which in the long run promotes a cultural change in the population regarding the importance of vaginal birth.
文摘The increasing demand for energy has intensified recently, requiring alternative sources to fossil fuels, which have become economically and environmentally unfeasible. On the other hand, the increasing land occupation in recent centuries is a growing problem, demanding greater efficiency, particularly in the reuse of abandoned areas, which has become an alternative. An interesting alternative would be installing energy facilities like solar, wind, biomass, and geothermal, in these areas. The objective of this paper is to develop a classification methodology, based on Artificial Intelligence (AI) and Quantum Theory (QT), to automatically carry out the classification of abandoned areas suitable for the settlement of these power plants. Artificial Neural Networks (ANNs) improved by the hybrid algorithm Quantum-behaved Particle Swarm Optimization (QPSO) together with the Levenberg-Marquardt Algorithm (LMA) were used for the classification task. In terms of Mean Squared Error (MSE), the QPSO-LMA approach achieved a decrease of 19.6% in relation to the classical LMA training with random initial weights. Moreover, the model’s accuracy showed an increase of 7.3% for the QPSO-LMA over the LMA. To validate this new approach, it was also tested on six different datasets available in the UCI Machine Learning Repository and seven classical techniques established in the literature. For the problem of installing photovoltaic plants in abandoned areas, the knowledge acquired with the solar dataset can be extrapolated to other regions.
文摘Magnetite (Fe<sub>3</sub>O<sub>4</sub>) crystals have been synthesized from the natural iron sands of Tegal Lenga Beach with HCl (37%) as a solvent. Tegal Lenga Beach is a stretch of beach located in Kalisada Village, Seririt District, Buleleng Regency, Bali Province, Indonesia. Iron sand samples were obtained by extracting local natural sand from Tegal Lenga Beach by magnetic separation method. The iron sand sample was ground with agate mortar for 15 hours, then washed and rinsed with deionized water (DI water). Furthermore, the fine powder sample of iron sand was dried on a hotplate at a temperature of 80˚C until all the water had evaporated. Eighty grams of fine iron sand powder dissolved in 200 mL HCl (37%) while stirring with a hot plate magnetic stirrer at a temperature of 100˚C with a rotating speed of 600 rpm for 30 minutes. This solution was filtered through Wattman filter paper No. 42;then the filtrate was dried using a hot plate at a temperature of 100˚C to form a crust. This crust is then ground in an agate mortar until it becomes a fine powder of iron sand. Furthermore, the iron sand fine powder filtrate sample was divided into four equal parts which were then calcined at temperatures of 300˚C, 400˚C, 450˚C, and 500˚C for 30 minutes, respectively. It was found that the fine powder of iron sand from the natural sand of the Tegal Lenga Beach consisted mostly of 84.26% metal oxide magnetite. The synthesized magnetite crystal has a tetrahedral structure with lattice parameters of a = b = (5.927 ± 0.0180) Åand c = (16.774 ± 0.0145) Å. Magnetite crystals have granular and lumpy grains with an average grain size of (94,560 ± 10,1397) μm. In relation to the values obtained from the hysteresis curve, namely the remanent magnetization of 9.6672 emu/gr, saturation magnetization of 45.3491 emu/gr, coercive magnetic field strength of 0.0242 T, and saturation magnetic field strength of 0, 2938 T, then this magnetite crystal is classified as a weak ferromagnetic material.
文摘Objective:The aim of this research is to explore the life experiences of schizophrenic families in accompanying the recovery process.Methods:This study uses a qualitative method with descriptive phenomenology to explain phenomena from family experiences.The number of the participants was eight families who had family members with schizophrenia.Sampling was determined by purposive sampling.Data were collected through in-depth interviews and analyzed using the Colaizzi method.Results:The results of this study show four themes that emerged including(1)psychological burden on the family,(2)families needing support in the recovery process,(3)obstacles due to social stigma,and(4)family gratitude for being able to pass the test patiently.Conclusion:The schizophrenia family’s journey in the recovery process is very long.They are required to endure in assisting the recovery process.Experiences felt by the family include feelings,obstacles,and hopes that arise in carrying out their role to assist the recovery process which aims to improve the health of schizophrenia patients.The findings from this study provide insight for nurses to be able to pay attention to family psychological problems by strengthening families through home visits and health promotion related to the recovery process of survivor schizophrenia.
基金Research Group“Family Health Care Studies”to facilitate research activities.Faculty of Nursing,Universitas Jember for supporting research.
文摘Incorrect family behavior in caring for the dental and oral health of preschool-aged children can affect the incidence of dental caries in these children and can cause more serious health problems in the future if not treated immediately,so it is important to find the right solution.This study aims to determine the effect of family counseling on dental and oral care for preschoolers.This study uses a narrative literature review method.Search articles using 5 databases(Pubmed,ScienceDirect,SpringerLink,ProQuest,and Google Scholar)to search for articles with the keywords family counseling AND Oral health AND Early Childhood Caries AND Behavior Change AND Family and the article selection process refers to the Flow diagram of the PRISMA Statement 2020.The results showed that there were 7 articles analyzed in this study.The implementation of family counseling has a significant effect in increasing self-efficacy,knowledge,ability,and motivation of the family,as well as the behavior of the child,to reduce the risk of dental caries in preschool-age children,taking into account several conditions.It was determined that family counseling is effective in reducing the incidence of dental caries in preschool children.
文摘Background:Nowdays,both of parents are working to fulfill their family needs and family financial.However,this condition effected separation of family that have a negative impact for children.Children can lose of a primary caregiver who can endanger the welfare of children.Purpose:To analyzed the relationship between family separation and nutritional status of under-five children aged in Panti District of Jember Regency.Methods:A cross-sectional design was conducted among 53 families using total sampling.A family background questionnaire was used to measure sociodemographics and separation of family.Among 53 families were 78.2%of separation with father,while 38.6%of children with a good nutrition status.Kruskal Wallis and One-Way Anova was performed to answer the objective of this study.Results:The result showed that,there were no correlation between length of separation with nutritional status(F=0.377;P-value=0,688).Meanwhile,distance of separation wascorrelated with nutritional status(c2=8.310;P-value=0,016).Conclusion:Parents need to improve relationships,communication and the distribution of proper autonomy in family.It can make the nutritional status and health level of the child becomes better.
文摘Background:Family is an essential element in caring for clients with hypertension.Appropriate hypertension management can reduce health risks during the treatment.Health coaching in family is a critical intervention to control and manage hypertension through providing education,information,and skills intervention are needed to support lifestyle improvements,manage chronic conditions,and prevent complications of hypertension.This literature study describes health coaching for controlling blood pressure among clients with hypertension in the family.Methods:Narrative literature review was performed to select the article that relates to health coaching of hypertension in the family using search engines including PubMed,ProQuest,SpringerLink,ScienceDirect,and Google Scholar by using keywords health coaching,family,hypertension,and blood pressure.The analysis of articles was carried out using four stages based on the PRISMA flowchart diagram.Results:The results indicated eight articles that were analyzed in this study.Interactive health coaching interventions based on a healthy lifestyle carried out with patients and families effectively improve medication adherence and reduce systolic and diastolic blood pressure.Meanwhile,health coaching applied regarding the principles including motivation,discussion,interviews and goal setting to influence behavior change and self-management.Conclusions:That health coaching applied for families with clients with hypertension is effect on reducing blood pressure and other changes,including knowledge,self-efficacy,and behavior towards health services for patients with hypertension.Therefore,health coaching for the family could be used as a family intervention for clients with hypertension during home health care.
文摘A review of coreflood experiments for chemically enhanced oil recovery(EOR)is presented in this paper,particularly surfactant-polymer(SP)and alkali-surfactant-polymer(ASP)processes.The objective of this review is to gain a general outlook and insight from coreflood experiments injecting SP or ASP slug as tertiary recovery.The discussion is separated into sections based on relevant core and fluid properties as well as surfactant selection and SP/ASP slug design and their impact on incremental recovery.Most studies in this review have been published within the last twenty years but few older coreflood works have been included for benchmarking.Parameters in each reviewed study have been summarized in tables to help readers gain detailed observation.Lessons learned from these past experiments should help other chemical EOR practitioners or students of the field in benchmarking or improving the outcomes of their future SP/ASP experiments.
基金the erf115 mutant(SALK_021981)ERF115SDRX,ERF115OE,and pERF115:NLS-GUS/GFP(Heyman et al.,2013)+4 种基金Javier Paz Ares for the phr1 phl1 double mutant and pho2the CBGP’s Plant Facility Service and Bioinformatic Unit for help with plant growth,treatments,and bioinformatics analysessupported by grants from the Spanish Government BIO2017-82209-R and PID2020-113479RB-I00 granted by MCIN/AEI/10.13039/501100011033/to J.C.P and by the"Severo Ochoa Programfor Centres of Excellence in R&D"from the Agencia Estatal de Investigacio´n of Spain(grant SEV-2016-06722017-2021)to the C.B.G.P.M.P.G.G.is supported by a postdoctoral contract associated with the"Severo Ochoa Program"and a UPM talent attraction contract.C.M.C.and M.S.-B.are supported by a predoctoral fellowship(BES-2017-082152 and PRE2019-088076 respectively)associated with the Severo Ochoa Program.V.B.G.is supported by theMinistry ofUniversities(predoctoral fellowship FPU20/07453)G.C.was supported by the Biotechnology and Biological Sciences Research Council and the National Science Foundation(BBSRC-NSF),grant no.BB/V011294/1,and the Leverhulme Trust,grant no.RPG-2019-337.
文摘Climate change is increasing the frequency of extreme heat events that aggravate its negative impact on plant development and agricultural yield.Most experiments designed to study plant adaption to heat stress apply homogeneous high temperatures to both shoot and root.However,this treatment does not mimic the conditions in natural fields,where roots grow in a dark environment with a descending temperature gradient.Excessively high temperatures severely decrease cell division in the root meristem,compromising root growth,while increasing the division of quiescent center cells,likely in an attempt to maintain the stem cell niche under such harsh conditions.Here,we engineered the TGRooZ,a device that generates a temperature gradient for in vitro or greenhouse growth assays.The root systems of plants exposed to high shoot temperatures but cultivated in theTGRooZ grow efficiently and maintain their functionality to sustain proper shoot growth and development.Furthermore,gene expression and rhizosphere or root microbiomecomposition are significantly less affected in TGRooZ-grown roots than in high-temperature-grown roots,correlating with higher root functionality.Our data indicate that use of the TGRooZ in heat-stress studies can improve our knowledge of plant response to high temperatures,demonstrating its applicability from laboratory studies to the field.
文摘Tumor-associated macrophages （TAMs） play a critical role in melanoma growth and metastasis. Infiltration of TAMs correlates with the poor prognosis of melanoma. TAMs are differentiated from monocytes in response to the tumor microenvironment cue. However, the mechanism how TAMs adapt to the tumor microenvironment after differentiation from monocytes is not fully understood. In addition, specific identification of TAMs in melanoma is difficult because the expression of the most commonly used macrophage marker, CD68, is also expressed in melanoma cells. In an earlier study, we found by gene microarray analysis that seven members of the metallothionein （MTs） family were upregulated in melanoma-conditioned medium induced macrophages （MCIM-MO）. MTs have been implicated in zinc metabolism and inflammation. In the present study, we confirmed that expression of metallothionein is induced in M-CSF differentiated macrophages （M-CSF/M~） and MCIM-M~ at both the mRNA and protein levels using real-time PCR, immunofluorescence, and western blot analysis. Furthermore, we demonstrated the presence of metallothionein in melanoma tissues in vivo and that metallothionein was co-localized with TAMs markers, CD68 and CD163. Finally, we demonstrated the induction of the zinc importer gene Zip8 both in M-CSF/MO and MCIM-MO. Our study identifies metallothionein as a novel marker for TAMs and suggests that metaliothionein might play important roles in macrophage adaptation and function in the tumor microenvironment.
基金supported by the National Key Basic Research Program of China 2018YFA0902800(P.W.)the National Natural Science Foundation of China 31470819(P.W.)31622022(P.W.).
文摘Background:The concept of phase separation has been used to describe and interpret physicochemical phenomena in biological systems for decades.Many intracellular macromolecules undergo phase separation,where it plays important roles in gene regulation,cellular signaling,metabolic reactions and so on,due to its unique dynamic properties and biological effects.As the noticeable importance of phase separation,pioneer researchers have explored the possibility to introduce the synthetically engineered phase separation for applicable cell function.Results:In this article,we illustrated the application value of phase separation in synthetic biology.We described main states of phase separation in detail,summarized some ways to implement synthetic condensates and several methods to regulate phase separation,and provided a substantial amount of identical examples to illuminate the applications and perspectives of phase separation in synthetic biology.Conclusions:Multivalent interactions implement phase separation in synthetic biology.Small molecules,light control and spontaneous interactions induce and regulate phase separation.The synthetic condensates are widely used in signal amplifications,designer orthogonally non-membrane-bound organelles,metabolic pathways,gene regulations,signaling transductions and controllable platforms.Studies on quantitative analysis,more standardized modules and precise spatiotemporal control of synthetic phase separation may promote the further development of this field.
文摘For interventional cardiologists, it is very challenging to do percutaneous coronary interventions （PCI） in lesions of ihe left main, bifilrcations or of chronic total occlusion types. However, it is more challenging to demonstrate an evidence based rationale supporting the indications of PCI in these lesions. In this article, new questions are raised on the benefits and the mechanism of benefits for PCI of bifilrcations revolving large side branches such as the diagonal （DIAG）,
基金funded by the Directorate of Research and Community Engagement of Universitas Indonesia(NKB-773/UN2.RST/HKP.05.00/2020).
文摘Objective WHO recommends that every pregnant woman and newborn receive quality care throughout the pregnancy,delivery and postnatal periods.However,Maternal Mortality Ratio in Indonesia for 2015 reached 305 per 100000 live births,which exceeds the target of Sustainable Development Goals(<70 per 100000 live births).Receiving at least four times antenatal care(ANC4+)and skilled birth attendant(SBA)during childbirth is crucial for preventing maternal and neonatal deaths.The study aims to assess the determinants of ANC4+and SBA independently,evaluate the distribution of utilisation of ANC4+and SBA services,and further investigate the associations of two levels of continuity of services utilisation in Indonesia Design Data from the Indonesia Demographic and Health Survey,a cross-sectional and large-scale national survey conducted in 2017 were used.Setting This study was set in Indonesia.Participants The study involved ever-married women of reproductive age(15-49 years)and had given birth in the last 5 years prior to the survey(n=15288).The dependent variables are the use of ANC4+and SBA.Individual,family and community factors,such as age,age at first birth,level of education,employment status,parity,autonomy in healthcare decision-making,level of education,employment status of spouses,household income,mass media consumption residence and distance from health facilities were also measured.Results Results showed that 11632(76.1%)women received ANC4+and SBA during childbirth.Multivariate analysis revealed that age,age at first birth,and parity have a statistically significant association with continuity of services utilisation.The odds of using continuity of services were higher among women older than 34 years(adjusted OR(aOR)1.54;95%CI 1.31 to 1.80)compared with women aged 15-24 years.Women with a favourable distance from health facilities were more likely to receive continuity of services utilisation(aOR 1.39;95%CI 1.24 to 1.57).Conclusions The continuity of services utilisation is associated with age,reproductive status,family influence and accessibility-related factors.Findings demonstrated the importance of enhancing early reproductive health education for men and women.The health system reinforcement,community empowerment and multisectoral engagement enhance accessibility to health facilities,reduce financial and geographical barriers,and produce strong quality care.
