Background: A healthy normal skin is essential for a person’s physical and mental well being. It is an important aspect of their sexual attractiveness, a sense of well being and a sense of self confidence. Vitiligo i...Background: A healthy normal skin is essential for a person’s physical and mental well being. It is an important aspect of their sexual attractiveness, a sense of well being and a sense of self confidence. Vitiligo is an acquired depigmentation disorder of skin affecting 1% - 4% of the world population. Neither life threatening nor symptomatic (except that depigmented patches burn easily when exposed to the sun) the effects of vitiligo can be cosmetically and psychologically devastating. Because the disease is still not understood, there is a plethora of different treatments approaches, but they are largely unsatisfactory from patient’s perspective. Objective: To report the outcomes from oral use of an infusion of leaves of Solanum paniculatum L., Jacaranda brasiliensis and Sonchus oleraceus for treatment of vitiligo. Ethical issues: Study approved by the Research Ethics Committee of Hospital Federal dos Servidores do Estado do Rio de Janeiro (CAAE: 32143314.9.0000.5252). All participants confirmed the condition of volunteer by signing the Informed Consent Form. Methods: From October 2014 to October 2015 twelve subjects consumed daily four glasses (800 ml) of proposed phytotherapeutic preparation. Results: All subjects were highly satisfied about their outcomes. Total depigmentation was considered as a positive outcome because it is cosmetically acceptable. Total depigmentation was observed in presence of 80% or more of depigmenteted patches. Conclusions: The phytotherapeutic preparation proposed is effective on treatment of depigmenteted patches in vitiligo.展开更多
The brown mussel Perna perna(Linnaeus,1758)is a valuable resource for aquaculture in tropical and subtropical coastal regions.It presents desirable characteristics for biomonitoring,including being sessile,widely dist...The brown mussel Perna perna(Linnaeus,1758)is a valuable resource for aquaculture in tropical and subtropical coastal regions.It presents desirable characteristics for biomonitoring,including being sessile,widely distributed and abundant,and is a filter-feeder able to accumulate several classes of pollutants(e.g.,metals,hydrocarbons,among others).Mussels’biological responses to pollution exposure can be measured as biomarkers,which include alterations ranging from molecular to physiological levels,to estimate the degree of environmental contamination and its effects on biota.This full review compiles two decades(2000–2020)of literature concerning biological effects on P.perna mussel caused by environmental pollutants(i.e.,metals,hydrocarbons,and emerging pollutants),considering environmental and farm-based biomonitoring.Biochemical markers related to mussels’oxidative status were efficient for the biomonitoring of metals(i.e.,antioxidant enzymes associated with oxidative damage in biomolecules).Genotoxicity and cytotoxicity indicators(i.e.,comet,micronucleus,and neutral red assays)provided a depiction of hydrocarbon contamination.The neutral red assay gave a time-concentration cytotoxic response to a wide range of pollutants,including emerging pollutants(e.g.,pharmaceuticals and biocides)and hydrocarbons.Perna perna hemocyte parameters provided a useful approach for biocide biomonitoring.This paper summarizes useful biomarkers from molecular to physiological levels in this mussel species used to identify and quantify the degree of coastal pollution.An integrated biomarker analysis may provide a way to overcome possible biomarker variations and assess multi-polluted sites.Nevertheless,it is necessary to investigate biomarker variations according to natural factors(e.g.,season and gonad maturation stage)to standardize them for trustworthy biomonitoring.展开更多
This article aimed to show ideas about the themes: body suffering, nursing and Medical care, and Health Economics. To this end, we tried to put together a kaleidoscope of references that converged on the promotion of ...This article aimed to show ideas about the themes: body suffering, nursing and Medical care, and Health Economics. To this end, we tried to put together a kaleidoscope of references that converged on the promotion of autonomy and empowerment and, as a strategy for action, and then we can think of what to do to alleviate the suffering of patients.展开更多
Unlike hepatic haemorrhage following blunt abdominal trauma, spontaneous abdomen bleeding is rare, even in the presence of a hepatocellular adenoma (HA) or carcinoma. However, the diagnosis of a tumour underlying a ha...Unlike hepatic haemorrhage following blunt abdominal trauma, spontaneous abdomen bleeding is rare, even in the presence of a hepatocellular adenoma (HA) or carcinoma. However, the diagnosis of a tumour underlying a haematoma after liver trauma is unusual, especially when it occurs more after two years after the accident. Here, we report a case of a ruptured HA due to blunt abdominal trauma. A 36-year-old woman was admitted to our hospital with sudden onset of upper abdominal pain. Her medical history revealed a blunt abdominal trauma two years prior. Initial abdominal computed tomography scan revealed a large haematoma measuring more than 16 cm in diameter in the right lobe of the liver. Magnetic resonance imaging showed haemorrhagic areas and some regions with hepatocyte hyperplasia, suggesting HA. The patient underwent right hepatic lobectomy, and a histopathological examination confirmed a diagnosis of HA. In conclusion, it is important to consider that abdominal trauma may hide old, asymptomatic and not previously detected injuries, as in the case reported.展开更多
Political discussions are characterized by conflicts of interest, and decisions are made based on negotiations. In general, participants need to reinforce their opinions and influence other participants. In this conte...Political discussions are characterized by conflicts of interest, and decisions are made based on negotiations. In general, participants need to reinforce their opinions and influence other participants. In this context, it is important to know how allies and opponents are positioned, in order to understand the discussion dynamics and plan adequate actions. This paper suggests the use of social network visualizations to explicit oppositions and alliances in order to support the understanding and following of political discussions. A system which supports these visualizations was built. An experiment performed to test the proposed visualizations showed to which extent they can be more efficient in identifying information about clashes and alliances than an online discussion system can.展开更多
Background: Pregnancy-related low back pain (LBP) impacts pregnancy. Flexibilizing facilitates movements providing posture correction and pain relief. Objective: To analyze effects of a maximum static flexibility prog...Background: Pregnancy-related low back pain (LBP) impacts pregnancy. Flexibilizing facilitates movements providing posture correction and pain relief. Objective: To analyze effects of a maximum static flexibility program on pregnancy’s LBP. Methods: Clinical prospective randomized controlled trial. Setting: Brazilian Governmental Health Program’s prenatal care. Participants: 40 volunteer of pregnant women, gestational age between 20 and 31 weeks, with/without LBP randomly assigned to experimental group (EG) or control group (CG): EG n = 20 (E1 with LBP and E2 without LBP) and CG n = 20 (C1 with LBP and C2 without LBP). Interventions: EG intervention was sessions of static flexion. CG received conventional medical treatment. Pain intensity was measured by visual analog scale (VAS) of pain. Chi-square, Wilcoxon and the Kruskal-Wallis statistical tests were adopted. Results: Concerning percent variation (Δ%) E1 presented 56.4% reduction of LBP while E2, C1, C2 increased LBP by 2.9%, 0.1%, 0.5% respectively. Wilcoxon test outcome comparing pre- and post-test of experimental and control groups on pain intensity levels presented significant E1 p < 0.05. Kruskal-Wallis test comparing post-test C1 with E1 with E2 and C2 presented p < 0.05 (C1 post vs. E1 post: p = 0.006;C1 post vs. E2 post: p < 0.0001;C1 post vs. C2 post: p = 0.002), showing significant effect of the experimental treatment. Conclusion: Gains on LBP for EG show that the static flexibilizing exercises reduce and prevent pregnancy-related LBP.展开更多
Manganese peroxidase (MnP) is a ligninolytic enzyme that is involved in the removal of lignin from the cell wall of plants. This removal facilitates the access of hydrolytic enzymes to the carbohydrate polymers that a...Manganese peroxidase (MnP) is a ligninolytic enzyme that is involved in the removal of lignin from the cell wall of plants. This removal facilitates the access of hydrolytic enzymes to the carbohydrate polymers that are hydrolyzed to simple sugars, which allows the subsequent fermentation to obtain bioproducts, such as ethanol. In this work, response surface methodology (RSM) was employed to optimize the culture conditions on unexpensive substrate for MnP secretion by Trametes villosa. Three independent variables were evaluated (i.e., temperature, moisture content and pH). The crude extract containing MnP was used in the delignification experiment and it caused a reduction in lignin content for all residues tested: 35.05 ± 1.45 (%) for the sugar cane bagasse;63.11 ± 0.06 (%) for the sisal fiber and 39.61 ± 0.39 (%) for the coconut shell, under the reaction conditions tested after 4 hours of fermentation. The preliminary results exhibited the potential application of this enzyme in the removal of lignin from plant residues. However, the conditions should be evaluated and optimized for each residue type.展开更多
We know that increased population and unrestrained consumption are generating problems, which becomes critical for our planet. This impending context is part of a whole system, triggered by a logic operation which nee...We know that increased population and unrestrained consumption are generating problems, which becomes critical for our planet. This impending context is part of a whole system, triggered by a logic operation which needs to be reconsidered urgently. The consumer consciousness of tourism knows to what extent their different actions will help change something. To achieve this awareness of sustainable consumption requires a restructuring and reform of the cultural, social, and political aspects of the site and the citizen. With this vision and the proposal for a case study of tourism marketing consciousness, the objective of this study is to raise consumers＇ awareness of tourist destinations to develop their abilities to use the right information to make the right choices and to be ecologically responsible. Through this differentia/, every action carried out in the tourist spot is of singular importance to create sustainable added value for the citizen. In this case, tour operators, non-governmental organizations （NGOs）, and local governments should also invest in educational programs that guide these consumers to enjoy as citizens the tourist areas consciously and effectively. Thus, we believe that training in tourism will lead the stakeholders of consciousness tourist destination to feel protagonist in the broad economic context, social, political, and cultural society of the destination of their choices.展开更多
The concept of quality of life is multiple concerns as a cultural, social and environmental individuality. The aim of this study was to verify the levels of quality of life in elderly practitioners of physical activit...The concept of quality of life is multiple concerns as a cultural, social and environmental individuality. The aim of this study was to verify the levels of quality of life in elderly practitioners of physical activity comparing a active group with a control group The sample consisted of 159 physically independent and apparently healthy individuals of either sex, with mean age of 66.61 ± 4.73 years. Active group obtained mean 14.32 ± 0.763 in whoqol’s scores for levels of quality of life, the Control group (CG) obtained mean 13.31 ± 0.94 and p-value 0.05. The ANOVA with repeated samples showed higher values for active group when compared with control group after intervention, the significant level was p < 0.05. It must be recognized that not every aspect of human life is reduced to the practice of physical activity;however, it is an important instrument that generates well-being in this age group.展开更多
The Polycystic Ovary Syndrome (PCOS) is the most common androgenic disorder in women during reproductive life. PCOS may also be accompanied by metabolic syndrome and recent studies point to leptin as playing a role in...The Polycystic Ovary Syndrome (PCOS) is the most common androgenic disorder in women during reproductive life. PCOS may also be accompanied by metabolic syndrome and recent studies point to leptin as playing a role in disrupting infertility and in changing the energy balance in obese mice through its action on the hypothalamus. The aim is to assess the expression of the Polycomb & Trithorax Complexes genes in brain of mice transplanted with fat tissue from normal mice, in order to better understand the neuronal mechanisms underlying the reversion of PCOS. Three B6 V-Lepob/J mouse groups: Normal weight, obese and seven-day-treatment obese had their brain RNA extracted and submitted to an 84 Polycomb & Trithorax Complexes genes PCR Array plate and MetacoreTM pathways localization. Genomic profiles obtained were compared to the ones of the normal-weight-mice group. Differentially expressed genes were 13% and 26% respectively to control and treatment. Major changes were in genes: Snai1/31;Smarca1/?17;Dnmt3b/4.7;Ezh1/ 15. Altered genes were associated to canonical pathways and provided 3 networks related to epigenetics. Underlying neuronal changes caused by leptin in obese mice brain, there is an important role being played by the histone code. Here there is evidence that leptin drives the chromatin packing to a more condensed pattern. Upregulation of methyltransferase genes, like Ezh1, favors this thought. In summary the Polycomb & Trithorax complexes might answer for the silencing of some downregulated genes in the obese mice brain when exposed to leptin.展开更多
CM （contelat management） is a strategic discipline that should support the information assets of a company. Although there are some technological instruments structuring this work, the methods that have been used mu...CM （contelat management） is a strategic discipline that should support the information assets of a company. Although there are some technological instruments structuring this work, the methods that have been used must have improvement to a better use. In this sense, IA （information architecture）, as a process that helps users to manage and find information, can collaborate with the organization of this assets allowing the best identification and categorization of information, as well as providing improvements in the website navigation in Intranets and Internet. This article introduces part of a research that deals with the use of IA for developing and structuring the project of Dataprev about the content management for Brazilian social security system.展开更多
Freshwater environments are the main ecosystems subjected to various anthropogenic impacts, which have caused the waterborne transmission of diseases caused mainly by bacteria. The main objective of this work was to c...Freshwater environments are the main ecosystems subjected to various anthropogenic impacts, which have caused the waterborne transmission of diseases caused mainly by bacteria. The main objective of this work was to carry out a systematic analysis through the literature on the main microorganisms found in impacted aquatic environments and to relate the data with the risks to public health. This review was planned, conducted and reported following the PRISMA protocol, which was used the PECO strategy. There performed searches for studies using the electronic databases PubMed, Medline and LILACS in September 2021, using the controlled search strategy: “Bacteria” and “Ecosystem” and “Environment” and “Aquatic” and “Impacted. The studies that met the eligibility criteria were considered eligible, with the participation of two independent reviewers. There found 1058 studies, of which were chosen only 31 to compose the results of this systematic review. Because of the results, there observed that the predominant bacterial genera in freshwater are: Pseudomonas, Aeromonas, and Escherichia, with the Asian continent presenting more varieties of bacterial species detected. These microorganisms are responsible for causing diseases that can lead to death, which shows the importance of constantly monitoring these ecosystems.展开更多
The emergency room is the entrance door of hospitals for patients who are in risk of life, and the role of the physiotherapist in this area is recognized as a qualified member of the team, helping to reduce the rate a...The emergency room is the entrance door of hospitals for patients who are in risk of life, and the role of the physiotherapist in this area is recognized as a qualified member of the team, helping to reduce the rate and time of orotracheal intubation, judicious use of invasive mechanical ventilation (MV) and non-invasive ventilation (NIV). The objective was to know the profile and performance of physical therapists in the emergency departments of hospitals in the state of S<span style="white-space:nowrap;">ã</span>o Paulo. Conducted through a semi-structured questionnaire covering personal and professional aspects, and analyzed and described in percentage form. Thirty-six questionnaires were analyzed, and it was observed that 92% provide emergency care, but only 25% work exclusively. Among the main reasons for admission to this sector are: acute respiratory failure (44%) and decreased level of consciousness (36.1%). Regarding the physiotherapeutic resources used in the emergency department, 97.2% make use of NIV, followed by monitoring of MV parameters (94.4%) and modification of parameters (94.4%). We also found that the average time of MV in this sector is 3 to 21 days (50%), and that 33% believe there is delay between indication and installation of NIV. The physiotherapist has much to contribute in emergency units, however, he must be trained through the search for technical and scientific knowledge, thus contributing to the consolidation of this area of expertise.展开更多
Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in vari...Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.展开更多
This aim of the present study was to analyze the hemodynamic responses during resistance exercise performed at different intensities and with different recovery intervals. This study was conducted on twenty-four appar...This aim of the present study was to analyze the hemodynamic responses during resistance exercise performed at different intensities and with different recovery intervals. This study was conducted on twenty-four apparently healthy male individuals (25.50 ± 3.72 years and 76.50 ± 4.50 kg) experienced in strength training. The volunteers performed a 1RM test to determine the training load for the study. Blood pressure and Rate Pressure Product were measured before and at the end of the exercise training. The only significant difference observed was in SBP during strength training at 70% intensity (121.7 ± 8.68, p = 0.039), which was lower than SBP at the remaining intensities of 80% (126.3 ± 7.11) and 90% (127.1 ± 7.51). It was concluded that strength training performed at different intensities and recovery intervals did not significantly alter most variables, changing only the SBP due to the intensity employed.展开更多
This research is an active pedagogical experience with surgeons who are specialized in reconstructive plastic surgery and nursing. The guiding questions were the statements of each Surgeon’s clients and what they thi...This research is an active pedagogical experience with surgeons who are specialized in reconstructive plastic surgery and nursing. The guiding questions were the statements of each Surgeon’s clients and what they think about them. Modeling the imaginary bodies of the patients and identify what they built in their minds, highlighting topics and the discussion about the practice made in clay modeling. Eight bodies were modeled, with six bodies with all the senses and two incomplete bodies with only the regions of the breasts and buttocks. It was concluded that there are diverse issues emerging such as gender, ethics, care, spirituality and dream as the fulfillment of the wishes of the patients. Where in the body can these surgeons act to improve the patients’ physical and quality of life? There is an important theme when we are generally welcoming women into an anamnesis that considers their body as a whole, but what is their expectation for each patient? This paper showed the importance of the preoperative evaluation of this whole, for the indication of repairs or contraindications of procedures that aim to improve the physical of the patients, with possible bodily surgical modifications as a form of modeling through liposuction, grafting or excision with lipectomy and withdrawal of excess skin to mitigate the effects of the transformations that deform the physical and end up harming the human relationship, especially women. This is a qualitative method showing the meanings of the bodies of the women represented in the modeling by the Surgeons. However, some surgeons stand out by the look of their practice, as greater sensitivity looking at the body as a whole, spiritual and emotional. They need to use their skills as surgical art and gift, to try to achieve a means, but not an end.展开更多
The aim of this study was to compare maturational stage and neuromuscular skills among soccer players and non-athletes, as well as to investigate the relationship between maturation and neuromuscular performance. Twen...The aim of this study was to compare maturational stage and neuromuscular skills among soccer players and non-athletes, as well as to investigate the relationship between maturation and neuromuscular performance. Twenty five adolescent males (14.3 ± 0.45 years) participated in the study and were divided into two groups: soccer players (SP – n = 13, 14.1 ± 0.3 years, 58.9 ± 6.90 kg, 1.72 ± 0.04 m, 19.9 ± 1.7 kg·m2, 13.3% ± 4.3% fat) and non-athletes (NA – n = 12, 14.5 ± 0.5 years, 57.3 ± 6.9 kg, 1,67 ± 0.06 m, 20.6 ± 3.9 kg·m2, 14.0% ± 5.7% fat). The square test and 20 m speed test were used to assess agility and speed, respectively. The Tanner self-assessment of pubic hair and genitalia development test was used to estimate maturational development. The Shapiro Wilk test was used to verify the normality of samples. For any data not normally distributed, the non-parametric Mann Whitney test, as well as Kendall’s Tau correlation test, were used. The p-values determined for agility (p = 0.017) and speed (p = 0.054) indicated that agility was the only variable significantly different between SP and NA. The SP and NA groups showed no difference in the levels of maturation (p = 0.41), and maturational status was not significantly correlated with agility (r = 0.013) or speed (r = ?0.003). Conclusion: Individuals who practiced football had better results for the agility test than non-athletes, even with no difference between the degree of maturation and speed. There is a low correlation between level of maturity and agility or speed.展开更多
Many plants pollinated by nectar-foraging animals have to maintain a balance between legitimate visitor attraction strategies and mechanisms that minimize illegitimate visits.This study investigated how floral display...Many plants pollinated by nectar-foraging animals have to maintain a balance between legitimate visitor attraction strategies and mechanisms that minimize illegitimate visits.This study investigated how floral display and neighboring species composition influences nectar robbing by hummingbirds in the tropical ornithophilous herb Heliconia spathocircinata.We tested the role of inflorescence display,flower abundance,and neighboring species in the reduction of nectar robbing in H.spathocircinata.Our results indicate that nectar robbing hummingbird activity was higher in moderately large inflorescence displays and that the frequency of nectar robbing in H.spathocircinata decreases with increased flower abundance and the presence of neighboring plant species.Neighboring non-ornithophilous plants decreased the frequency of nectar robbing in H.spathocircinata flowers to a greater extent than ornithophilous ones.These results suggest that nectar robbing hummingbirds are attracted to similar conditions that attract legitimate visitors and that spatial aggregation and mixed-species displays may represent a mechanism to dilute nectar robbing effects at an individual level.展开更多
Introduction: Polycystic ovarian syndrome (PCOS) is undoubtedly the commonest androgen disorder in woman’s fertile period and certainly one of the most prevalent causes of anovulation. The syndrome has an estimated p...Introduction: Polycystic ovarian syndrome (PCOS) is undoubtedly the commonest androgen disorder in woman’s fertile period and certainly one of the most prevalent causes of anovulation. The syndrome has an estimated prevalence of 4% - 10% among women of childbearing age. Previously, our group demonstrated the effect of gonadal white adipose tissue transplantation from wild-type lean and fertile female mice to isogenic obese anovulatory ob/ob mice. These complex metabolic interrelationships between obesity and PCOS have yet to be fully understood. The aim of this study was to evaluate the effect of gonadal white adipose tissue (WAT) transplantation from the wild-type lean and fertile female mice to isogenic obese, anovulatory mice (Lep ob/Lep ob) on the expression of glycolysis- and TCA cycle-related genes and obtain a general view of the glucose metabolism in the brain of these animals. Methods: Fifteen ob/ob mice ranging from 2 to 3 months of age were divided into 3 experimental groups: control normal weight (n = 5), obese control (n = 5) and obese 7 days leptin treated (n = 5). The whole brains of the mice were processed for RNA extraction. The samples from each group were used to perform PCR assays using an array plate containing 84 primers to study the glucose metabolism-related genes. Results: The glycolysis- and TCA cycle-related genes were significantly downregulated. The most significantly affected genes were as follows: for glycolysis (fold regulation with p < 0.05):Pgm1,Bpgm,Aldob, andEno3 (119, 45, 18, and 28 times less, respectively);and for the TCA cycle (fold regulation with p < 0.05):Cs,Idh3b, andMdh2 (84, 27, and 37 times less, respectively).Conclusion: The seven-day leptin treated mice show a decrease in the glucose metabolism. These results confirm the ability of the adipose tissue-derived hormone leptin to regulate early crucial genes that are related to glycolysis mechanisms and to the TCA cycle. This hormone seems to revert early the central physiological conditions that are associated with PCOS;however, the morphological alterations can only be observed within a 45-day treatment.展开更多
This is a retrospective study on gigantomastia correction in obesity facing the technique of nipple-areolar grafts and its complexity. The main question is the technical-surgical care during its execution aiming to ac...This is a retrospective study on gigantomastia correction in obesity facing the technique of nipple-areolar grafts and its complexity. The main question is the technical-surgical care during its execution aiming to achieve reparative results that can return to these women the desire to live with better quality of life and health. Method: We performed a retrospective study of all obese patients with severe gigantomastia who underwent reduction mammaplasty with an operative technique using the superior pedicle, with special care for the nipple-papillary grafts. The study was carried out at a single institution between 2001 and 2013, in a total of 30 cases. This operative technique was presented at first time in 1980, with no changes up to now. We emphasized the perfect decortication of the areola and nipples until they were translucent after the maneuvers of Schwartzman and subsequent grafts operated in both breasts. Results: Results were considered satisfactory, from the reparative and aesthetic point of view, emphasizing the degree of improvement observed in women undergoing technique. Discussion: We can say that during all this time of aesthetic and therapeutic-restorative surgery, due to its realization in a single surgical time, there was big impact on the aesthetics of patients and on their families, even taking into account possible complications in the post-operative. Conclusion: The superior pedicle technique, performed as described here, is a safe and reliable procedure in patients with severe gigantomastia.展开更多
文摘Background: A healthy normal skin is essential for a person’s physical and mental well being. It is an important aspect of their sexual attractiveness, a sense of well being and a sense of self confidence. Vitiligo is an acquired depigmentation disorder of skin affecting 1% - 4% of the world population. Neither life threatening nor symptomatic (except that depigmented patches burn easily when exposed to the sun) the effects of vitiligo can be cosmetically and psychologically devastating. Because the disease is still not understood, there is a plethora of different treatments approaches, but they are largely unsatisfactory from patient’s perspective. Objective: To report the outcomes from oral use of an infusion of leaves of Solanum paniculatum L., Jacaranda brasiliensis and Sonchus oleraceus for treatment of vitiligo. Ethical issues: Study approved by the Research Ethics Committee of Hospital Federal dos Servidores do Estado do Rio de Janeiro (CAAE: 32143314.9.0000.5252). All participants confirmed the condition of volunteer by signing the Informed Consent Form. Methods: From October 2014 to October 2015 twelve subjects consumed daily four glasses (800 ml) of proposed phytotherapeutic preparation. Results: All subjects were highly satisfied about their outcomes. Total depigmentation was considered as a positive outcome because it is cosmetically acceptable. Total depigmentation was observed in presence of 80% or more of depigmenteted patches. Conclusions: The phytotherapeutic preparation proposed is effective on treatment of depigmenteted patches in vitiligo.
基金financed in part by the Coordination of Superior Level Staff Improvement–Brazil(CAPES)–Finance Code 001–[Fernanda Silva dos Santos–doctoral fellowship 88882.457000/2019.1]Federal University of the State of Rio de Janeiro(UNIRIO)–[INOVA UNIRIO IN01/2019 attributed to Natascha Krepsky and INOVA UNIRIO IN01/2019 attributed to Raquel A.F.Neves]+1 种基金Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro-(FAPERJ)–[Number E-26/202.794/2018(CNE)]National Council for Scientific and Technological Development(CNPq)–[Number 301964/2018-1]attributed to Valéria Laneuville Teixeira。
文摘The brown mussel Perna perna(Linnaeus,1758)is a valuable resource for aquaculture in tropical and subtropical coastal regions.It presents desirable characteristics for biomonitoring,including being sessile,widely distributed and abundant,and is a filter-feeder able to accumulate several classes of pollutants(e.g.,metals,hydrocarbons,among others).Mussels’biological responses to pollution exposure can be measured as biomarkers,which include alterations ranging from molecular to physiological levels,to estimate the degree of environmental contamination and its effects on biota.This full review compiles two decades(2000–2020)of literature concerning biological effects on P.perna mussel caused by environmental pollutants(i.e.,metals,hydrocarbons,and emerging pollutants),considering environmental and farm-based biomonitoring.Biochemical markers related to mussels’oxidative status were efficient for the biomonitoring of metals(i.e.,antioxidant enzymes associated with oxidative damage in biomolecules).Genotoxicity and cytotoxicity indicators(i.e.,comet,micronucleus,and neutral red assays)provided a depiction of hydrocarbon contamination.The neutral red assay gave a time-concentration cytotoxic response to a wide range of pollutants,including emerging pollutants(e.g.,pharmaceuticals and biocides)and hydrocarbons.Perna perna hemocyte parameters provided a useful approach for biocide biomonitoring.This paper summarizes useful biomarkers from molecular to physiological levels in this mussel species used to identify and quantify the degree of coastal pollution.An integrated biomarker analysis may provide a way to overcome possible biomarker variations and assess multi-polluted sites.Nevertheless,it is necessary to investigate biomarker variations according to natural factors(e.g.,season and gonad maturation stage)to standardize them for trustworthy biomonitoring.
文摘This article aimed to show ideas about the themes: body suffering, nursing and Medical care, and Health Economics. To this end, we tried to put together a kaleidoscope of references that converged on the promotion of autonomy and empowerment and, as a strategy for action, and then we can think of what to do to alleviate the suffering of patients.
文摘Unlike hepatic haemorrhage following blunt abdominal trauma, spontaneous abdomen bleeding is rare, even in the presence of a hepatocellular adenoma (HA) or carcinoma. However, the diagnosis of a tumour underlying a haematoma after liver trauma is unusual, especially when it occurs more after two years after the accident. Here, we report a case of a ruptured HA due to blunt abdominal trauma. A 36-year-old woman was admitted to our hospital with sudden onset of upper abdominal pain. Her medical history revealed a blunt abdominal trauma two years prior. Initial abdominal computed tomography scan revealed a large haematoma measuring more than 16 cm in diameter in the right lobe of the liver. Magnetic resonance imaging showed haemorrhagic areas and some regions with hepatocyte hyperplasia, suggesting HA. The patient underwent right hepatic lobectomy, and a histopathological examination confirmed a diagnosis of HA. In conclusion, it is important to consider that abdominal trauma may hide old, asymptomatic and not previously detected injuries, as in the case reported.
文摘Political discussions are characterized by conflicts of interest, and decisions are made based on negotiations. In general, participants need to reinforce their opinions and influence other participants. In this context, it is important to know how allies and opponents are positioned, in order to understand the discussion dynamics and plan adequate actions. This paper suggests the use of social network visualizations to explicit oppositions and alliances in order to support the understanding and following of political discussions. A system which supports these visualizations was built. An experiment performed to test the proposed visualizations showed to which extent they can be more efficient in identifying information about clashes and alliances than an online discussion system can.
文摘Background: Pregnancy-related low back pain (LBP) impacts pregnancy. Flexibilizing facilitates movements providing posture correction and pain relief. Objective: To analyze effects of a maximum static flexibility program on pregnancy’s LBP. Methods: Clinical prospective randomized controlled trial. Setting: Brazilian Governmental Health Program’s prenatal care. Participants: 40 volunteer of pregnant women, gestational age between 20 and 31 weeks, with/without LBP randomly assigned to experimental group (EG) or control group (CG): EG n = 20 (E1 with LBP and E2 without LBP) and CG n = 20 (C1 with LBP and C2 without LBP). Interventions: EG intervention was sessions of static flexion. CG received conventional medical treatment. Pain intensity was measured by visual analog scale (VAS) of pain. Chi-square, Wilcoxon and the Kruskal-Wallis statistical tests were adopted. Results: Concerning percent variation (Δ%) E1 presented 56.4% reduction of LBP while E2, C1, C2 increased LBP by 2.9%, 0.1%, 0.5% respectively. Wilcoxon test outcome comparing pre- and post-test of experimental and control groups on pain intensity levels presented significant E1 p < 0.05. Kruskal-Wallis test comparing post-test C1 with E1 with E2 and C2 presented p < 0.05 (C1 post vs. E1 post: p = 0.006;C1 post vs. E2 post: p < 0.0001;C1 post vs. C2 post: p = 0.002), showing significant effect of the experimental treatment. Conclusion: Gains on LBP for EG show that the static flexibilizing exercises reduce and prevent pregnancy-related LBP.
文摘Manganese peroxidase (MnP) is a ligninolytic enzyme that is involved in the removal of lignin from the cell wall of plants. This removal facilitates the access of hydrolytic enzymes to the carbohydrate polymers that are hydrolyzed to simple sugars, which allows the subsequent fermentation to obtain bioproducts, such as ethanol. In this work, response surface methodology (RSM) was employed to optimize the culture conditions on unexpensive substrate for MnP secretion by Trametes villosa. Three independent variables were evaluated (i.e., temperature, moisture content and pH). The crude extract containing MnP was used in the delignification experiment and it caused a reduction in lignin content for all residues tested: 35.05 ± 1.45 (%) for the sugar cane bagasse;63.11 ± 0.06 (%) for the sisal fiber and 39.61 ± 0.39 (%) for the coconut shell, under the reaction conditions tested after 4 hours of fermentation. The preliminary results exhibited the potential application of this enzyme in the removal of lignin from plant residues. However, the conditions should be evaluated and optimized for each residue type.
文摘We know that increased population and unrestrained consumption are generating problems, which becomes critical for our planet. This impending context is part of a whole system, triggered by a logic operation which needs to be reconsidered urgently. The consumer consciousness of tourism knows to what extent their different actions will help change something. To achieve this awareness of sustainable consumption requires a restructuring and reform of the cultural, social, and political aspects of the site and the citizen. With this vision and the proposal for a case study of tourism marketing consciousness, the objective of this study is to raise consumers＇ awareness of tourist destinations to develop their abilities to use the right information to make the right choices and to be ecologically responsible. Through this differentia/, every action carried out in the tourist spot is of singular importance to create sustainable added value for the citizen. In this case, tour operators, non-governmental organizations （NGOs）, and local governments should also invest in educational programs that guide these consumers to enjoy as citizens the tourist areas consciously and effectively. Thus, we believe that training in tourism will lead the stakeholders of consciousness tourist destination to feel protagonist in the broad economic context, social, political, and cultural society of the destination of their choices.
文摘The concept of quality of life is multiple concerns as a cultural, social and environmental individuality. The aim of this study was to verify the levels of quality of life in elderly practitioners of physical activity comparing a active group with a control group The sample consisted of 159 physically independent and apparently healthy individuals of either sex, with mean age of 66.61 ± 4.73 years. Active group obtained mean 14.32 ± 0.763 in whoqol’s scores for levels of quality of life, the Control group (CG) obtained mean 13.31 ± 0.94 and p-value 0.05. The ANOVA with repeated samples showed higher values for active group when compared with control group after intervention, the significant level was p < 0.05. It must be recognized that not every aspect of human life is reduced to the practice of physical activity;however, it is an important instrument that generates well-being in this age group.
文摘The Polycystic Ovary Syndrome (PCOS) is the most common androgenic disorder in women during reproductive life. PCOS may also be accompanied by metabolic syndrome and recent studies point to leptin as playing a role in disrupting infertility and in changing the energy balance in obese mice through its action on the hypothalamus. The aim is to assess the expression of the Polycomb & Trithorax Complexes genes in brain of mice transplanted with fat tissue from normal mice, in order to better understand the neuronal mechanisms underlying the reversion of PCOS. Three B6 V-Lepob/J mouse groups: Normal weight, obese and seven-day-treatment obese had their brain RNA extracted and submitted to an 84 Polycomb & Trithorax Complexes genes PCR Array plate and MetacoreTM pathways localization. Genomic profiles obtained were compared to the ones of the normal-weight-mice group. Differentially expressed genes were 13% and 26% respectively to control and treatment. Major changes were in genes: Snai1/31;Smarca1/?17;Dnmt3b/4.7;Ezh1/ 15. Altered genes were associated to canonical pathways and provided 3 networks related to epigenetics. Underlying neuronal changes caused by leptin in obese mice brain, there is an important role being played by the histone code. Here there is evidence that leptin drives the chromatin packing to a more condensed pattern. Upregulation of methyltransferase genes, like Ezh1, favors this thought. In summary the Polycomb & Trithorax complexes might answer for the silencing of some downregulated genes in the obese mice brain when exposed to leptin.
文摘CM （contelat management） is a strategic discipline that should support the information assets of a company. Although there are some technological instruments structuring this work, the methods that have been used must have improvement to a better use. In this sense, IA （information architecture）, as a process that helps users to manage and find information, can collaborate with the organization of this assets allowing the best identification and categorization of information, as well as providing improvements in the website navigation in Intranets and Internet. This article introduces part of a research that deals with the use of IA for developing and structuring the project of Dataprev about the content management for Brazilian social security system.
文摘Freshwater environments are the main ecosystems subjected to various anthropogenic impacts, which have caused the waterborne transmission of diseases caused mainly by bacteria. The main objective of this work was to carry out a systematic analysis through the literature on the main microorganisms found in impacted aquatic environments and to relate the data with the risks to public health. This review was planned, conducted and reported following the PRISMA protocol, which was used the PECO strategy. There performed searches for studies using the electronic databases PubMed, Medline and LILACS in September 2021, using the controlled search strategy: “Bacteria” and “Ecosystem” and “Environment” and “Aquatic” and “Impacted. The studies that met the eligibility criteria were considered eligible, with the participation of two independent reviewers. There found 1058 studies, of which were chosen only 31 to compose the results of this systematic review. Because of the results, there observed that the predominant bacterial genera in freshwater are: Pseudomonas, Aeromonas, and Escherichia, with the Asian continent presenting more varieties of bacterial species detected. These microorganisms are responsible for causing diseases that can lead to death, which shows the importance of constantly monitoring these ecosystems.
文摘The emergency room is the entrance door of hospitals for patients who are in risk of life, and the role of the physiotherapist in this area is recognized as a qualified member of the team, helping to reduce the rate and time of orotracheal intubation, judicious use of invasive mechanical ventilation (MV) and non-invasive ventilation (NIV). The objective was to know the profile and performance of physical therapists in the emergency departments of hospitals in the state of S<span style="white-space:nowrap;">ã</span>o Paulo. Conducted through a semi-structured questionnaire covering personal and professional aspects, and analyzed and described in percentage form. Thirty-six questionnaires were analyzed, and it was observed that 92% provide emergency care, but only 25% work exclusively. Among the main reasons for admission to this sector are: acute respiratory failure (44%) and decreased level of consciousness (36.1%). Regarding the physiotherapeutic resources used in the emergency department, 97.2% make use of NIV, followed by monitoring of MV parameters (94.4%) and modification of parameters (94.4%). We also found that the average time of MV in this sector is 3 to 21 days (50%), and that 33% believe there is delay between indication and installation of NIV. The physiotherapist has much to contribute in emergency units, however, he must be trained through the search for technical and scientific knowledge, thus contributing to the consolidation of this area of expertise.
文摘Scars, when in good evolution, result in a smooth, thin and discreet tissue. Keloid scars, however, are a type of abnormal and exacerbated repair response to tissue injury, whether in surgical interventions or in various injuries, which present in a prominent and gross way. In this context, there is an excess of collagen deposition in the tissue repair process, which can lead to the formation of keloids. The diagnosis of the condition presented is made by the medical professional or by the patient himself after the surgical intervention or skin injury. Under this analysis, protruding, rough and bad-looking scars are identified. In addition, we highlight the existence of keloids similar to large tumors, described as Jorge Lobo disease. The treatment encompasses massages, compressions, corticosteroids, chemotherapy, collagenase and cryotherapy. At first, we used corticosteroid-based massages, and then we started using compressive dressings until we started intrakeloid infiltrations with injectable triamcinolone. Triamcinolone 10 mg injectable—1/10—in 0.9% saline, with syringe and fixed needle 0.3 mm × 8 mm, intralesional infiltrate, in this context, proved to be effective for its treatment when applied sequentially and linearly. In cases where the medication was applied, there was an improvement after 21 days of application and a definitive improvement 2 months after the injury. In comparison, on the other hand, patients who were not subjected to the application of the medication may improve after 4 months of the injury or worsen compared to the initial case. We have come to the conclusion that this procedure may be one of the chosen ones for the treatment of keloid scars, being one of the most recommended for cases of keloid already installed.
文摘This aim of the present study was to analyze the hemodynamic responses during resistance exercise performed at different intensities and with different recovery intervals. This study was conducted on twenty-four apparently healthy male individuals (25.50 ± 3.72 years and 76.50 ± 4.50 kg) experienced in strength training. The volunteers performed a 1RM test to determine the training load for the study. Blood pressure and Rate Pressure Product were measured before and at the end of the exercise training. The only significant difference observed was in SBP during strength training at 70% intensity (121.7 ± 8.68, p = 0.039), which was lower than SBP at the remaining intensities of 80% (126.3 ± 7.11) and 90% (127.1 ± 7.51). It was concluded that strength training performed at different intensities and recovery intervals did not significantly alter most variables, changing only the SBP due to the intensity employed.
文摘This research is an active pedagogical experience with surgeons who are specialized in reconstructive plastic surgery and nursing. The guiding questions were the statements of each Surgeon’s clients and what they think about them. Modeling the imaginary bodies of the patients and identify what they built in their minds, highlighting topics and the discussion about the practice made in clay modeling. Eight bodies were modeled, with six bodies with all the senses and two incomplete bodies with only the regions of the breasts and buttocks. It was concluded that there are diverse issues emerging such as gender, ethics, care, spirituality and dream as the fulfillment of the wishes of the patients. Where in the body can these surgeons act to improve the patients’ physical and quality of life? There is an important theme when we are generally welcoming women into an anamnesis that considers their body as a whole, but what is their expectation for each patient? This paper showed the importance of the preoperative evaluation of this whole, for the indication of repairs or contraindications of procedures that aim to improve the physical of the patients, with possible bodily surgical modifications as a form of modeling through liposuction, grafting or excision with lipectomy and withdrawal of excess skin to mitigate the effects of the transformations that deform the physical and end up harming the human relationship, especially women. This is a qualitative method showing the meanings of the bodies of the women represented in the modeling by the Surgeons. However, some surgeons stand out by the look of their practice, as greater sensitivity looking at the body as a whole, spiritual and emotional. They need to use their skills as surgical art and gift, to try to achieve a means, but not an end.
文摘The aim of this study was to compare maturational stage and neuromuscular skills among soccer players and non-athletes, as well as to investigate the relationship between maturation and neuromuscular performance. Twenty five adolescent males (14.3 ± 0.45 years) participated in the study and were divided into two groups: soccer players (SP – n = 13, 14.1 ± 0.3 years, 58.9 ± 6.90 kg, 1.72 ± 0.04 m, 19.9 ± 1.7 kg·m2, 13.3% ± 4.3% fat) and non-athletes (NA – n = 12, 14.5 ± 0.5 years, 57.3 ± 6.9 kg, 1,67 ± 0.06 m, 20.6 ± 3.9 kg·m2, 14.0% ± 5.7% fat). The square test and 20 m speed test were used to assess agility and speed, respectively. The Tanner self-assessment of pubic hair and genitalia development test was used to estimate maturational development. The Shapiro Wilk test was used to verify the normality of samples. For any data not normally distributed, the non-parametric Mann Whitney test, as well as Kendall’s Tau correlation test, were used. The p-values determined for agility (p = 0.017) and speed (p = 0.054) indicated that agility was the only variable significantly different between SP and NA. The SP and NA groups showed no difference in the levels of maturation (p = 0.41), and maturational status was not significantly correlated with agility (r = 0.013) or speed (r = ?0.003). Conclusion: Individuals who practiced football had better results for the agility test than non-athletes, even with no difference between the degree of maturation and speed. There is a low correlation between level of maturity and agility or speed.
基金the Brazilian National Council for Scientific and Technological Development(CNPq)with a research grant to Maria Alice S.Alves(PQ processes#306.579/2018-9)Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro(FAPERJ)supported Maria Alice S.Alves with research grant(CNE process#E-26/202.835/2018).
文摘Many plants pollinated by nectar-foraging animals have to maintain a balance between legitimate visitor attraction strategies and mechanisms that minimize illegitimate visits.This study investigated how floral display and neighboring species composition influences nectar robbing by hummingbirds in the tropical ornithophilous herb Heliconia spathocircinata.We tested the role of inflorescence display,flower abundance,and neighboring species in the reduction of nectar robbing in H.spathocircinata.Our results indicate that nectar robbing hummingbird activity was higher in moderately large inflorescence displays and that the frequency of nectar robbing in H.spathocircinata decreases with increased flower abundance and the presence of neighboring plant species.Neighboring non-ornithophilous plants decreased the frequency of nectar robbing in H.spathocircinata flowers to a greater extent than ornithophilous ones.These results suggest that nectar robbing hummingbirds are attracted to similar conditions that attract legitimate visitors and that spatial aggregation and mixed-species displays may represent a mechanism to dilute nectar robbing effects at an individual level.
文摘Introduction: Polycystic ovarian syndrome (PCOS) is undoubtedly the commonest androgen disorder in woman’s fertile period and certainly one of the most prevalent causes of anovulation. The syndrome has an estimated prevalence of 4% - 10% among women of childbearing age. Previously, our group demonstrated the effect of gonadal white adipose tissue transplantation from wild-type lean and fertile female mice to isogenic obese anovulatory ob/ob mice. These complex metabolic interrelationships between obesity and PCOS have yet to be fully understood. The aim of this study was to evaluate the effect of gonadal white adipose tissue (WAT) transplantation from the wild-type lean and fertile female mice to isogenic obese, anovulatory mice (Lep ob/Lep ob) on the expression of glycolysis- and TCA cycle-related genes and obtain a general view of the glucose metabolism in the brain of these animals. Methods: Fifteen ob/ob mice ranging from 2 to 3 months of age were divided into 3 experimental groups: control normal weight (n = 5), obese control (n = 5) and obese 7 days leptin treated (n = 5). The whole brains of the mice were processed for RNA extraction. The samples from each group were used to perform PCR assays using an array plate containing 84 primers to study the glucose metabolism-related genes. Results: The glycolysis- and TCA cycle-related genes were significantly downregulated. The most significantly affected genes were as follows: for glycolysis (fold regulation with p < 0.05):Pgm1,Bpgm,Aldob, andEno3 (119, 45, 18, and 28 times less, respectively);and for the TCA cycle (fold regulation with p < 0.05):Cs,Idh3b, andMdh2 (84, 27, and 37 times less, respectively).Conclusion: The seven-day leptin treated mice show a decrease in the glucose metabolism. These results confirm the ability of the adipose tissue-derived hormone leptin to regulate early crucial genes that are related to glycolysis mechanisms and to the TCA cycle. This hormone seems to revert early the central physiological conditions that are associated with PCOS;however, the morphological alterations can only be observed within a 45-day treatment.
文摘This is a retrospective study on gigantomastia correction in obesity facing the technique of nipple-areolar grafts and its complexity. The main question is the technical-surgical care during its execution aiming to achieve reparative results that can return to these women the desire to live with better quality of life and health. Method: We performed a retrospective study of all obese patients with severe gigantomastia who underwent reduction mammaplasty with an operative technique using the superior pedicle, with special care for the nipple-papillary grafts. The study was carried out at a single institution between 2001 and 2013, in a total of 30 cases. This operative technique was presented at first time in 1980, with no changes up to now. We emphasized the perfect decortication of the areola and nipples until they were translucent after the maneuvers of Schwartzman and subsequent grafts operated in both breasts. Results: Results were considered satisfactory, from the reparative and aesthetic point of view, emphasizing the degree of improvement observed in women undergoing technique. Discussion: We can say that during all this time of aesthetic and therapeutic-restorative surgery, due to its realization in a single surgical time, there was big impact on the aesthetics of patients and on their families, even taking into account possible complications in the post-operative. Conclusion: The superior pedicle technique, performed as described here, is a safe and reliable procedure in patients with severe gigantomastia.
