In recent years,advancements in autonomous vehicle technology have accelerated,promising safer and more efficient transportation systems.However,achieving fully autonomous driving in challenging weather conditions,par...In recent years,advancements in autonomous vehicle technology have accelerated,promising safer and more efficient transportation systems.However,achieving fully autonomous driving in challenging weather conditions,particularly in snowy environments,remains a challenge.Snow-covered roads introduce unpredictable surface conditions,occlusions,and reduced visibility,that require robust and adaptive path detection algorithms.This paper presents an enhanced road detection framework for snowy environments,leveraging Simple Framework forContrastive Learning of Visual Representations(SimCLR)for Self-Supervised pretraining,hyperparameter optimization,and uncertainty-aware object detection to improve the performance of YouOnly Look Once version 8(YOLOv8).Themodel is trained and evaluated on a custom-built dataset collected from snowy roads in Tromsø,Norway,which covers a range of snow textures,illumination conditions,and road geometries.The proposed framework achieves scores in terms of mAP@50 equal to 99%and mAP@50–95 equal to 97%,demonstrating the effectiveness of YOLOv8 for real-time road detection in extreme winter conditions.The findings contribute to the safe and reliable deployment of autonomous vehicles in Arctic environments,enabling robust decision-making in hazardous weather conditions.This research lays the groundwork for more resilient perceptionmodels in self-driving systems,paving the way for the future development of intelligent and adaptive transportation networks.展开更多
Face masks play a pivotal role in preventing infection transmission.However,the capture of infection-sourced particles in face masks poses challenges related to reuse,necessitating proper disposal.We developed a self-...Face masks play a pivotal role in preventing infection transmission.However,the capture of infection-sourced particles in face masks poses challenges related to reuse,necessitating proper disposal.We developed a self-sterilizable polypropylene-based membrane for face masks to address challenges associated with infection transmission prevention.The membrane,created using 3D printing,underwent functionalization with zinc oxide(ZnO)and polydopamine(PDA)-TEMPO to achieve broad-spectrum light absorption and facilitate self-sterilization through photocatalytic and photothermal effects upon light exposure.The hydrophobic surface(water contact angle:133±2°)minimized moisture accumulation,and the membrane exhibited robust mechanical properties,including shear strength(1.25±0.5kPa)and peel resistance strength(112.8±11.2kPa).The evaluation demonstrated stability in airflow(0-500cm^(3)/s)and excellent aerosol filtration efficiency(94.8±0.6%)for particles(PM 0.3,PM 2.5,PM 10),comparable to commercial masks.The membrane showed antibacterial efficacy over five uses in a simulated respiratory environment.Safety assessments confirmed biocompatibility through cytocompatibility and skin irritation assays.In conclusion,this membrane offers efficient filtration and photo-triggered sterilization,presenting a promising solution for next-generation face masks to address concerns related to reuse,disposal,and infection control.展开更多
Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a kno...Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a knowledge mapping was generated based on published studies to investigate the characteristics of bibliometric studies on acupuncture and the extent of duplicate publications,with the overarching goal of providing a comprehensive overview of the knowledge structure in this field.Methods:This cross-sectional study used three databases(PubMed,Web of Science,and Scopus)to identify relevant studies up to May 1,2024.In addition,the reference lists were retrieved as a supplement.To track research trends,we employed Microsoft Excel and R software to extract,code,and analyze information.Study selection,data extraction,and validation were performed independently by at least two reviewers.The reporting quality of included studies was assessed using the Preliminary guideline for reporting bibliometric reviews of the biomedical literature(BIBLIO).Results:Among the 6,221 bibliometric reviews examined,113 relevant publications were identified,80 focusing on various diseases/conditions.The annual number of publications has gradually increased,with the output in the past four years being 3.52 times higher than that before 2020.China(106)and Chengdu University of Traditional Chinese Medicine(16)have the highest number of publications.The most prolific author is Fan-Rong Liang,with six articles.The first bibliometric study,by Hai-Yan Li,was published in 2010.Journal of Pain Research,with 36 articles,holds the most publications.The top three diseases:diseases of the nervous system;symptoms,signs,or clinical findings not elsewhere classified;and mental,behavioral,or neurodevelopmental disorders.There may be potential duplication in research on 13 diseases/conditions,notably stroke,migraine,pain/analgesia,cancer pain,shoulder pain,facial paralysis/bell’s palsy,chronic pain,and cognitive impairment.In BIBLIO,the most frequently missing items are issues/topics(item 2),quality assessment(item 11),and descriptive findings(item 13).Conclusion:This study demonstrates that acupuncture bibliometrics is actively utilized to identify dominant diseases/conditions,aiding scholars in understand the knowledge structure and main topics.Although the number of related studies is increasing,with an average of 25 studies annually,overlap in some areas highlights the need for adherence to reporting guidelines and careful topic selection to ensure truly valuable insights and knowledge contributions.The adherence to BIBLIO’s 20 proposed items across analyzed articles,highlighting important in reporting practices.展开更多
Even in small concentrations,toxic metals like lead,cadmium,and mercury are dangerous to the environment and human health.Environmental monitoring depends on precisely identifying these heavy metals,particularly cadmi...Even in small concentrations,toxic metals like lead,cadmium,and mercury are dangerous to the environment and human health.Environmental monitoring depends on precisely identifying these heavy metals,particularly cadmium ions(Cd(Ⅱ)).In this study,we present a novel screen-printed carbon electrode(SPCE)modified with single crystallineα-Fe_(2)O_(3)nano-hexagons that functions as a sensor for detecting Cd(Ⅱ).The performance of the fabricated sensor was thoroughly assessed and compared with unmodified SPCE using the voltammetric method.The crystalline structure of the synthesizedα-Fe_(2)O_(3)nano-hexagons was confirmed through XRD,and surface analysis revealed an average diameter and thickness of 86 nm and 9 nm,respectively.Theα-Fe_(2)O_(3)modified SPCE yields a 7-fold enhanced response(at pH 5.0 vs.Ag/AgCl)to Cd(Ⅱ)than bare SPCE.The modified electrode effectively detects Cd(Ⅱ)with a linear response range of up to 333.0μmol/L and a detection limit of 0.65 nmol/L under ideal circumstances.This newly fabricated sensor offers significant potential for environmental monitoring applications by providing outstanding practicality,anti-interference ability,and repeatability for detecting Cd(Ⅱ)in water samples.展开更多
Deep Learning(DL)offers promising solutions for analyzing wearable signals and gaining valuable insights into cognitive disorders.While previous review studies have explored various aspects of DL in cognitive healthca...Deep Learning(DL)offers promising solutions for analyzing wearable signals and gaining valuable insights into cognitive disorders.While previous review studies have explored various aspects of DL in cognitive healthcare,there remains a lack of comprehensive analysis that integrates wearable signals,data processing techniques,and the broader applications,benefits,and challenges of DL methods.Addressing this limitation,our study provides an extensive review of DL’s role in cognitive healthcare,with a particular emphasis on wearables,data processing,and the inherent challenges in this field.This review also highlights the considerable promise of DL approaches in addressing a broad spectrum of cognitive issues.By enhancing the understanding and analysis of wearable signal modalities,DL models can achieve remarkable accuracy in cognitive healthcare.Convolutional Neural Network(CNN),Recurrent Neural Network(RNN),and Long Short-term Memory(LSTM)networks have demonstrated improved performance and effectiveness in the early diagnosis and progression monitoring of neurological disorders.Beyond cognitive impairment detection,DL has been applied to emotion recognition,sleep analysis,stress monitoring,and neurofeedback.These applications lead to advanced diagnosis,personalized treatment,early intervention,assistive technologies,remote monitoring,and reduced healthcare costs.Nevertheless,the integration of DL and wearable technologies presents several challenges,such as data quality,privacy,interpretability,model generalizability,ethical concerns,and clinical adoption.These challenges emphasize the importance of conducting future research in areas such as multimodal signal analysis and explainable AI.The findings of this review aim to benefit clinicians,healthcare professionals,and society by facilitating better patient outcomes in cognitive healthcare.展开更多
Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock...Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock for the inheritance and development of TM.To meet the growing demand for high-quality healthcare,it is imperative to integrate TM with modern technology to address the issue of insufficient evidence for the efficacy of TM.展开更多
Objective:To investigate the antioxidant and cytotoxic activity of the fruits of Calamus tenuis Roxb.Methods:The preliminary phytochemical group tests were done,which revealed the presence of alkaloid,tannin,flavonoid...Objective:To investigate the antioxidant and cytotoxic activity of the fruits of Calamus tenuis Roxb.Methods:The preliminary phytochemical group tests were done,which revealed the presence of alkaloid,tannin,flavonoid and steroid.The dried fruit was extracted in soxhlet apparatus using petroleum ether,ethyl acetate and methanol.Antioxidant potential of each extract was evaluated using total phenol content,total flavonoid content,cupric reducing antioxidant capacity,1,1-diphenyl-2-picrylhydrazyl radical scavenging activity,and total antioxidant capacity determinations.Results:The extracts were found to possess moderate to high amounts of phenolic and flavonoid contents.In cupric reducing antioxidant capacity assay the extracts showed moderate reducing power which increases with concentration.Scavenging of 1,1-diphenyl-2-picrylhydrazyl radical was found to rise with concentration with lowest IC_(50)value for methanol extract,which was confirmed by total antioxidant activity test that shows highest(95 mg/g of extract)in ascorbic acid equivalent for methanol extract.In Brine shrimp lethality bioassay the methanol and petroleum ether extracts were found to be toxic to Brine shrimp nauplii,with LC_(50)of 25.53μg/mL and 28.07μg/mL respectively while the LC_(50)of the reference vincristine sulphate was 1.32μg/mL.Ethyl acetate extract was found to be moderately cytotoxic showing LC_(50)of 47.79μg/mL.Conclusions:The results of the present study suggest that the fruits of Calamus tenuis Roxb possess antioxidant and cytotoxic potential.Moreover,phytochemical screening reveals the presence of alkaloid,tannin,flavonoid and steroid,which may be responsible for the observed bioactivities.展开更多
Background:Acupuncture protocols are essential as they guide study design and improve the quality of clinical trial,thus preventing avoid research waste.Given the increasing number of publications on acupuncture proto...Background:Acupuncture protocols are essential as they guide study design and improve the quality of clinical trial,thus preventing avoid research waste.Given the increasing number of publications on acupuncture protocols,this study aimed to assess the publications trends of acupuncture protocols over the past two decades and provided an overview for future research directions.Methods:Publications focusing on acupuncture protocols in clinical settings were retrieved and compiled from the Web of Science Core Collection spanning the period from 2004 to 2023.CiteSpace and Microsoft Excel software were used to analyze the relationship of publication with countries,institutions,authors,co-cited author,journals,references,keywords and other literature aspects.Results:This study analyzed 721 articles encompassing acupuncture protocols.A continuous yet fluctuating growth in publications volume were observed from 2004 to 2023.Notably,China stands at the forefront in contributing to acupuncture protocols,publishing 513 papers and demonstrating a high centrality score of 1.07 in cooperative network.Furthermore,China has fostered close collaborations with the USA and South Korea.Beijing University of Chinese Medicine(89),Zhishun Liu(36)and Trials(306)emerged as the top contributors in terms of institution,author,and journal,respectively.However,inter-institutional and author collaboration was relatively weak.Macpherson H was the most frequently cited author.High-frequency keywords included“randomized controlled trials”,“acupuncture”,“management”,“study protocol”,“quality of life”.Analysis of timeline diagram of keywords indicated that“functional dyspepsia”,“stroke”,“electroacupuncture”,and“colorectal cancer”were the research development trends and focus.Conclusion:Clinical acupuncture protocols have experienced robust development over the past two decades,with current research hotspots focusing on disease management and quality of life,which remain key research concerns.Moreover,we advocate for researchers to publish acupuncture protocols,which remain key research concerns.This approach allows for thorough pre-study planning of methodologies and objectives,enhancing scientific rigor through peer review,thereby laying the foundation for conducting high-quality research.展开更多
The fundamental frequency plays a significant part in understanding and perceiving the pitch of a sound. The pitch is a fundamental attribute employed in numerous speech-related works. For fundamental frequency extrac...The fundamental frequency plays a significant part in understanding and perceiving the pitch of a sound. The pitch is a fundamental attribute employed in numerous speech-related works. For fundamental frequency extraction, several algorithms have been developed which one to use relies on the signal’s characteristics and the surrounding noise. Thus, the algorithm’s noise resistance becomes more critical than ever for precise fundamental frequency estimation. Nonetheless, numerous state-of-the-art algorithms face struggles in achieving satisfying outcomes when confronted with speech recordings that are noisy with low signal-to-noise ratio (SNR) values. Also, most of the recent techniques utilize different frame lengths for pitch extraction. From this point of view, This research considers different frame lengths on male and female speech signals for fundamental frequency extraction. Also, analyze the frame length dependency on the speech signal analytically to understand which frame length is more suitable and effective for male and female speech signals specifically. For the validation of our idea, we have utilized the conventional autocorrelation function (ACF), and state-of-the-art method BaNa. This study puts out a potent idea that will work better for speech processing applications in noisy speech. From experimental results, the proposed idea represents which frame length is more appropriate for male and female speech signals in noisy environments.展开更多
The biathlon,an Olympic sporting discipline that combines cross-country skiing with rifle marksmanship,entails considerable physiological demands,as well as fine motor control while shooting after intense exercise and...The biathlon,an Olympic sporting discipline that combines cross-country skiing with rifle marksmanship,entails considerable physiological demands,as well as fine motor control while shooting after intense exercise and under mental pressure.Although much of our knowledge about cross-country skiing is probably also applicable to the biathlon,carrying the rifle and shooting under stress make this discipline somewhat unique.The present review summarizes and examines the scientific literature related to biathlon performance,with a focus on physiological and biomechanical factors and shooting technique,as well as psychophysiological aspects of shooting performance.We conclude with suggestions for future research designed to extend our knowledge about the biathlon,which is presently quite limited.2018 Published by Elsevier B.V.on behalf of Shanghai University of Sport.This is an open access article under the CC BY-NC-ND license.(http://creativecommons.org/licenses/by-nc-nd/4.0/).展开更多
Purpose:This study was aimed to determine associations of accelerometer-determined time and bouts of sedentary behavior,light physical activity(LPA),and moderate-to-vigorous PA(MVPA)with sarcopenia and incident falls ...Purpose:This study was aimed to determine associations of accelerometer-determined time and bouts of sedentary behavior,light physical activity(LPA),and moderate-to-vigorous PA(MVPA)with sarcopenia and incident falls over 12 months.Methods:A total of 3334 Swedish 70-year-olds were assessed for sarcopenia,as defined by the revised definition of the European Working Group on Sarcopenia in Older People.Assessments were based on low scores for appendicular lean mass(dual-energy X-ray absorptiometry),hand grip strength,and the Timed Up and Go test.For 7 days after baseline,total time and total number of bouts(≥10 min of continuous activity at a given intensity)of activity performed at sedentary,LPA,and MVPA intensities were assessed by accelerometer.Incident falls were self-reported 6 months and 12 months after baseline.Results:Only 1.8%of participants had probable or confirmed sarcopenia.After multivariable adjustment for other levels of activity,only greater MVPA time was associated with a decreased likelihood of having low appendicular lean mass,low hand grip strength,and slow Timed Up and Go time as defined by the European Working Group on Sarcopenia in Older People criteria(all p<0.05),and only MVPA time was associated with lower likelihood of probable or confirmed sarcopenia(odds ratio=0.80,95%confidence interval:0.71-0.91 h/week).Similar associations were identified for total number of bouts,with no evidence of threshold effects for longer duration of bouts of MVPA.A total of 14%of participants reported-1 fall,but neither total time nor bouts of activity was associated with incident falls(all p>0.05).Conclusion:Higher amounts of accelerometer-determined MVPA are consistently associated with a decreased likelihood of sarcopenia and its components,regardless of the length of bouts or amounts of sedentary behavior.展开更多
BACKGROUND The clinical presentation of gastroesophageal reflux disease(GERD) shows a large symptom variation also in different intensities among patients. As several studies have shown, there is a large overlap in th...BACKGROUND The clinical presentation of gastroesophageal reflux disease(GERD) shows a large symptom variation also in different intensities among patients. As several studies have shown, there is a large overlap in the symptomatic spectrum between proven GERD and other disorders such as dyspepsia, functional heartburn and/or somatoform disorders.AIM To prospectively evaluate the GERD patients with and without somatoform disorders before and after laparoscopic antireflux surgery.METHODS In a tertiary referral center for foregut surgery over a period of 3 years patients with GERD, qualifying for the indication of laparoscopic antireflux surgery, were investigated prospectively regarding their symptomatic spectrum in order to identify GERD and associated somatoform disorders. Assessment of symptoms was performed by an instrument for the evaluation of somatoform disorders[Somatoform Symptom Index(SSI) > 17]. Quality of life was evaluated by Gastrointestinal Quality of Life Index(GIQLI).RESULTS In 123 patients an indication for laparoscopic antireflux surgery was established and in 43 patients further medical therapy was suggested. The portion of somatoform tendencies in the total patient population was 20.48%(34 patients).Patients with a positive SSI had a preoperative GIQLI of 77(32-111). Patients with a normal SSI had a GIQLI of 105(29-140)(P < 0.0001). In patients with GERD the quality of life could be normalized from preoperative reduced values of GIQLI102(47-140) to postoperative values of 117(44-144). In patients with GERD and somatoform disorders, the GIQLI was improved from preoperative GIQLI 75(47-111) to postoperative 95(44-122)(P < 0.0043).CONCLUSION Patients with GERD and associated somatoform disorders have significantly worse levels of quality of life. The latter patients can also benefit from laparoscopic fundoplication, however they will not reach a normal level.展开更多
This article describes a technique that allows a photovoltaic (PV) production unit to obtain the maximum power at all times. Here, we use the MPPT control via fuzzy logic on a DC/DC boost-type converter. In order to a...This article describes a technique that allows a photovoltaic (PV) production unit to obtain the maximum power at all times. Here, we use the MPPT control via fuzzy logic on a DC/DC boost-type converter. In order to achieve our goals, we first proceeded to model a PV panel. The resulting model offers the possibility to better account for the influence of different physical quantities such as temperature, irradiation, series resistance, shunt resistance and diode saturation current. Thus, the maximum power to be provided by the PV system is acquired by fuzzification and defuzzification of the input and output variables of the converter. Subsequently, a virtual model of an 800 Watt PV prototype is implemented in the Matlab environment. The simulation results obtained and presented, show the feasibility and efficiency of the proposed technology. Indeed, for a disturbance caused by a variation in brightness, our system guarantees the maximum stable power after 1.4</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">s. While for a load variation, the maximum power is continuous.展开更多
Background:Cross-country skiing(XCS)racing,a popular international winter sport,is complex and challenging from physical,technical,and tactical perspectives.Despite the vast amount of research focusing on this sport,n...Background:Cross-country skiing(XCS)racing,a popular international winter sport,is complex and challenging from physical,technical,and tactical perspectives.Despite the vast amount of research focusing on this sport,no review has yet addressed the pacing strategies of elite XCS racers or the factors that influence their performance.The aim was to review the scientific literature in an attempt to determine the effects of pacing strategy on the performance of elite XCS racers.Methods:Four electronic databases were searched using relevant subject headings and keywords.Only original research articles published in peerreviewed journals and the English language and addressing performance,biomechanics,physiology,and anthropometry of XCS racers were reviewed.Results:All 27 included articles applied correlative designs to study the effectiveness of different pacing strategies.None of the articles involved the use of an experimental design.Furthermore,potential changes in external conditions(e.g.,weather,ski properties)were not taken into consideration.A comparable number of studies focused on the skating or classical technique.In most cases,positive pacing was observed,with certain indications that higher-level athletes and those with more endurance and strength utilized a more even pacing strategy.The ability to achieve and maintain a long cycle length on all types of terrain was an important determinant of performance in all of the included studies,which was not the case for cycle rate.In general,uphill performance was closely related to overall race performance,with uphill performance being most closely correlated to the success of female skiers and performance on flat terrain being more important for male skiers.Moreover,pacing was coupled to the selection and distribution of technique during a race,with faster skiers employing more double poling and kick double poling,less diagonal stride,and more V2(double dance)than V1(single dance)skating across a race.Conclusion:We propose that skiers at all levels can improve their performance with more specific training in techniques(i.e.,maintaining long cycles without compromising cycle rate and selecting appropriate techniques)in combination with training for endurance and more strength.Furthermore,we would advise less experienced skiers and/or those with lower levels of performance to apply a more even pacing strategy rather than a positive one(i.e.,starting the race too fast).2018 Published by Elsevier B.V.on behalf of Shanghai University of Sport.This is an open access article under the CC BY-NC-ND license.(http://creativecommons.org/licenses/by-nc-nd/4.0/).展开更多
文摘In recent years,advancements in autonomous vehicle technology have accelerated,promising safer and more efficient transportation systems.However,achieving fully autonomous driving in challenging weather conditions,particularly in snowy environments,remains a challenge.Snow-covered roads introduce unpredictable surface conditions,occlusions,and reduced visibility,that require robust and adaptive path detection algorithms.This paper presents an enhanced road detection framework for snowy environments,leveraging Simple Framework forContrastive Learning of Visual Representations(SimCLR)for Self-Supervised pretraining,hyperparameter optimization,and uncertainty-aware object detection to improve the performance of YouOnly Look Once version 8(YOLOv8).Themodel is trained and evaluated on a custom-built dataset collected from snowy roads in Tromsø,Norway,which covers a range of snow textures,illumination conditions,and road geometries.The proposed framework achieves scores in terms of mAP@50 equal to 99%and mAP@50–95 equal to 97%,demonstrating the effectiveness of YOLOv8 for real-time road detection in extreme winter conditions.The findings contribute to the safe and reliable deployment of autonomous vehicles in Arctic environments,enabling robust decision-making in hazardous weather conditions.This research lays the groundwork for more resilient perceptionmodels in self-driving systems,paving the way for the future development of intelligent and adaptive transportation networks.
基金supported by Key Scientific Research Projects of Colleges and Universities in Henan Province(No.23ZX016)University Innovation Research and Training Program(No.202110467004)the Distinguished Professor Program of Institutions of Higher Learning in Henan Province,National Key R&D Program of China(No.2019YFE0101200).
文摘Face masks play a pivotal role in preventing infection transmission.However,the capture of infection-sourced particles in face masks poses challenges related to reuse,necessitating proper disposal.We developed a self-sterilizable polypropylene-based membrane for face masks to address challenges associated with infection transmission prevention.The membrane,created using 3D printing,underwent functionalization with zinc oxide(ZnO)and polydopamine(PDA)-TEMPO to achieve broad-spectrum light absorption and facilitate self-sterilization through photocatalytic and photothermal effects upon light exposure.The hydrophobic surface(water contact angle:133±2°)minimized moisture accumulation,and the membrane exhibited robust mechanical properties,including shear strength(1.25±0.5kPa)and peel resistance strength(112.8±11.2kPa).The evaluation demonstrated stability in airflow(0-500cm^(3)/s)and excellent aerosol filtration efficiency(94.8±0.6%)for particles(PM 0.3,PM 2.5,PM 10),comparable to commercial masks.The membrane showed antibacterial efficacy over five uses in a simulated respiratory environment.Safety assessments confirmed biocompatibility through cytocompatibility and skin irritation assays.In conclusion,this membrane offers efficient filtration and photo-triggered sterilization,presenting a promising solution for next-generation face masks to address concerns related to reuse,disposal,and infection control.
基金supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202006)the High-level traditional Chinese medicine key subject construction project of National Administration of Traditional Chinese Medicine-Evidence-based Traditional Chinese Medicine(ZYYZDXK-2023249).
文摘Background:The bibliometrics of acupuncture are growing rapidly.However,the absence of reporting guidelines may lead to significant duplication and waste,thereby undermining the research’s value.To address this,a knowledge mapping was generated based on published studies to investigate the characteristics of bibliometric studies on acupuncture and the extent of duplicate publications,with the overarching goal of providing a comprehensive overview of the knowledge structure in this field.Methods:This cross-sectional study used three databases(PubMed,Web of Science,and Scopus)to identify relevant studies up to May 1,2024.In addition,the reference lists were retrieved as a supplement.To track research trends,we employed Microsoft Excel and R software to extract,code,and analyze information.Study selection,data extraction,and validation were performed independently by at least two reviewers.The reporting quality of included studies was assessed using the Preliminary guideline for reporting bibliometric reviews of the biomedical literature(BIBLIO).Results:Among the 6,221 bibliometric reviews examined,113 relevant publications were identified,80 focusing on various diseases/conditions.The annual number of publications has gradually increased,with the output in the past four years being 3.52 times higher than that before 2020.China(106)and Chengdu University of Traditional Chinese Medicine(16)have the highest number of publications.The most prolific author is Fan-Rong Liang,with six articles.The first bibliometric study,by Hai-Yan Li,was published in 2010.Journal of Pain Research,with 36 articles,holds the most publications.The top three diseases:diseases of the nervous system;symptoms,signs,or clinical findings not elsewhere classified;and mental,behavioral,or neurodevelopmental disorders.There may be potential duplication in research on 13 diseases/conditions,notably stroke,migraine,pain/analgesia,cancer pain,shoulder pain,facial paralysis/bell’s palsy,chronic pain,and cognitive impairment.In BIBLIO,the most frequently missing items are issues/topics(item 2),quality assessment(item 11),and descriptive findings(item 13).Conclusion:This study demonstrates that acupuncture bibliometrics is actively utilized to identify dominant diseases/conditions,aiding scholars in understand the knowledge structure and main topics.Although the number of related studies is increasing,with an average of 25 studies annually,overlap in some areas highlights the need for adherence to reporting guidelines and careful topic selection to ensure truly valuable insights and knowledge contributions.The adherence to BIBLIO’s 20 proposed items across analyzed articles,highlighting important in reporting practices.
文摘Even in small concentrations,toxic metals like lead,cadmium,and mercury are dangerous to the environment and human health.Environmental monitoring depends on precisely identifying these heavy metals,particularly cadmium ions(Cd(Ⅱ)).In this study,we present a novel screen-printed carbon electrode(SPCE)modified with single crystallineα-Fe_(2)O_(3)nano-hexagons that functions as a sensor for detecting Cd(Ⅱ).The performance of the fabricated sensor was thoroughly assessed and compared with unmodified SPCE using the voltammetric method.The crystalline structure of the synthesizedα-Fe_(2)O_(3)nano-hexagons was confirmed through XRD,and surface analysis revealed an average diameter and thickness of 86 nm and 9 nm,respectively.Theα-Fe_(2)O_(3)modified SPCE yields a 7-fold enhanced response(at pH 5.0 vs.Ag/AgCl)to Cd(Ⅱ)than bare SPCE.The modified electrode effectively detects Cd(Ⅱ)with a linear response range of up to 333.0μmol/L and a detection limit of 0.65 nmol/L under ideal circumstances.This newly fabricated sensor offers significant potential for environmental monitoring applications by providing outstanding practicality,anti-interference ability,and repeatability for detecting Cd(Ⅱ)in water samples.
基金the Asian Institute of Technology,Khlong Nueng,Thailand for their support in carrying out this study。
文摘Deep Learning(DL)offers promising solutions for analyzing wearable signals and gaining valuable insights into cognitive disorders.While previous review studies have explored various aspects of DL in cognitive healthcare,there remains a lack of comprehensive analysis that integrates wearable signals,data processing techniques,and the broader applications,benefits,and challenges of DL methods.Addressing this limitation,our study provides an extensive review of DL’s role in cognitive healthcare,with a particular emphasis on wearables,data processing,and the inherent challenges in this field.This review also highlights the considerable promise of DL approaches in addressing a broad spectrum of cognitive issues.By enhancing the understanding and analysis of wearable signal modalities,DL models can achieve remarkable accuracy in cognitive healthcare.Convolutional Neural Network(CNN),Recurrent Neural Network(RNN),and Long Short-term Memory(LSTM)networks have demonstrated improved performance and effectiveness in the early diagnosis and progression monitoring of neurological disorders.Beyond cognitive impairment detection,DL has been applied to emotion recognition,sleep analysis,stress monitoring,and neurofeedback.These applications lead to advanced diagnosis,personalized treatment,early intervention,assistive technologies,remote monitoring,and reduced healthcare costs.Nevertheless,the integration of DL and wearable technologies presents several challenges,such as data quality,privacy,interpretability,model generalizability,ethical concerns,and clinical adoption.These challenges emphasize the importance of conducting future research in areas such as multimodal signal analysis and explainable AI.The findings of this review aim to benefit clinicians,healthcare professionals,and society by facilitating better patient outcomes in cognitive healthcare.
文摘Traditional Medicine(TM),particularly Traditional Chinese Medicine(TCM),is an indispensable component of the global healthcare system,offering unique insights to modern medical science.Clinical efficacy is the bedrock for the inheritance and development of TM.To meet the growing demand for high-quality healthcare,it is imperative to integrate TM with modern technology to address the issue of insufficient evidence for the efficacy of TM.
基金Supported by the Department of PharmacyJahangirnagar University,Bangladesh.
文摘Objective:To investigate the antioxidant and cytotoxic activity of the fruits of Calamus tenuis Roxb.Methods:The preliminary phytochemical group tests were done,which revealed the presence of alkaloid,tannin,flavonoid and steroid.The dried fruit was extracted in soxhlet apparatus using petroleum ether,ethyl acetate and methanol.Antioxidant potential of each extract was evaluated using total phenol content,total flavonoid content,cupric reducing antioxidant capacity,1,1-diphenyl-2-picrylhydrazyl radical scavenging activity,and total antioxidant capacity determinations.Results:The extracts were found to possess moderate to high amounts of phenolic and flavonoid contents.In cupric reducing antioxidant capacity assay the extracts showed moderate reducing power which increases with concentration.Scavenging of 1,1-diphenyl-2-picrylhydrazyl radical was found to rise with concentration with lowest IC_(50)value for methanol extract,which was confirmed by total antioxidant activity test that shows highest(95 mg/g of extract)in ascorbic acid equivalent for methanol extract.In Brine shrimp lethality bioassay the methanol and petroleum ether extracts were found to be toxic to Brine shrimp nauplii,with LC_(50)of 25.53μg/mL and 28.07μg/mL respectively while the LC_(50)of the reference vincristine sulphate was 1.32μg/mL.Ethyl acetate extract was found to be moderately cytotoxic showing LC_(50)of 47.79μg/mL.Conclusions:The results of the present study suggest that the fruits of Calamus tenuis Roxb possess antioxidant and cytotoxic potential.Moreover,phytochemical screening reveals the presence of alkaloid,tannin,flavonoid and steroid,which may be responsible for the observed bioactivities.
基金supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202006)the High-level traditional Chinese medicine key subject construction project of National Administration of Traditional Chinese Medicine--Evidence-based Traditional Chinese Medicine(ZYYZDXK-2023249).
文摘Background:Acupuncture protocols are essential as they guide study design and improve the quality of clinical trial,thus preventing avoid research waste.Given the increasing number of publications on acupuncture protocols,this study aimed to assess the publications trends of acupuncture protocols over the past two decades and provided an overview for future research directions.Methods:Publications focusing on acupuncture protocols in clinical settings were retrieved and compiled from the Web of Science Core Collection spanning the period from 2004 to 2023.CiteSpace and Microsoft Excel software were used to analyze the relationship of publication with countries,institutions,authors,co-cited author,journals,references,keywords and other literature aspects.Results:This study analyzed 721 articles encompassing acupuncture protocols.A continuous yet fluctuating growth in publications volume were observed from 2004 to 2023.Notably,China stands at the forefront in contributing to acupuncture protocols,publishing 513 papers and demonstrating a high centrality score of 1.07 in cooperative network.Furthermore,China has fostered close collaborations with the USA and South Korea.Beijing University of Chinese Medicine(89),Zhishun Liu(36)and Trials(306)emerged as the top contributors in terms of institution,author,and journal,respectively.However,inter-institutional and author collaboration was relatively weak.Macpherson H was the most frequently cited author.High-frequency keywords included“randomized controlled trials”,“acupuncture”,“management”,“study protocol”,“quality of life”.Analysis of timeline diagram of keywords indicated that“functional dyspepsia”,“stroke”,“electroacupuncture”,and“colorectal cancer”were the research development trends and focus.Conclusion:Clinical acupuncture protocols have experienced robust development over the past two decades,with current research hotspots focusing on disease management and quality of life,which remain key research concerns.Moreover,we advocate for researchers to publish acupuncture protocols,which remain key research concerns.This approach allows for thorough pre-study planning of methodologies and objectives,enhancing scientific rigor through peer review,thereby laying the foundation for conducting high-quality research.
文摘The fundamental frequency plays a significant part in understanding and perceiving the pitch of a sound. The pitch is a fundamental attribute employed in numerous speech-related works. For fundamental frequency extraction, several algorithms have been developed which one to use relies on the signal’s characteristics and the surrounding noise. Thus, the algorithm’s noise resistance becomes more critical than ever for precise fundamental frequency estimation. Nonetheless, numerous state-of-the-art algorithms face struggles in achieving satisfying outcomes when confronted with speech recordings that are noisy with low signal-to-noise ratio (SNR) values. Also, most of the recent techniques utilize different frame lengths for pitch extraction. From this point of view, This research considers different frame lengths on male and female speech signals for fundamental frequency extraction. Also, analyze the frame length dependency on the speech signal analytically to understand which frame length is more suitable and effective for male and female speech signals specifically. For the validation of our idea, we have utilized the conventional autocorrelation function (ACF), and state-of-the-art method BaNa. This study puts out a potent idea that will work better for speech processing applications in noisy speech. From experimental results, the proposed idea represents which frame length is more appropriate for male and female speech signals in noisy environments.
文摘The biathlon,an Olympic sporting discipline that combines cross-country skiing with rifle marksmanship,entails considerable physiological demands,as well as fine motor control while shooting after intense exercise and under mental pressure.Although much of our knowledge about cross-country skiing is probably also applicable to the biathlon,carrying the rifle and shooting under stress make this discipline somewhat unique.The present review summarizes and examines the scientific literature related to biathlon performance,with a focus on physiological and biomechanical factors and shooting technique,as well as psychophysiological aspects of shooting performance.We conclude with suggestions for future research designed to extend our knowledge about the biathlon,which is presently quite limited.2018 Published by Elsevier B.V.on behalf of Shanghai University of Sport.This is an open access article under the CC BY-NC-ND license.(http://creativecommons.org/licenses/by-nc-nd/4.0/).
基金supported by the Swedish Research Council(Grant number 2011-2976)DS is supported by an Australian National Health and Medical Research Council(NHMRC)R.D.Wright Biomedical Career Development Fellowship(Grant number GNT1123014).
文摘Purpose:This study was aimed to determine associations of accelerometer-determined time and bouts of sedentary behavior,light physical activity(LPA),and moderate-to-vigorous PA(MVPA)with sarcopenia and incident falls over 12 months.Methods:A total of 3334 Swedish 70-year-olds were assessed for sarcopenia,as defined by the revised definition of the European Working Group on Sarcopenia in Older People.Assessments were based on low scores for appendicular lean mass(dual-energy X-ray absorptiometry),hand grip strength,and the Timed Up and Go test.For 7 days after baseline,total time and total number of bouts(≥10 min of continuous activity at a given intensity)of activity performed at sedentary,LPA,and MVPA intensities were assessed by accelerometer.Incident falls were self-reported 6 months and 12 months after baseline.Results:Only 1.8%of participants had probable or confirmed sarcopenia.After multivariable adjustment for other levels of activity,only greater MVPA time was associated with a decreased likelihood of having low appendicular lean mass,low hand grip strength,and slow Timed Up and Go time as defined by the European Working Group on Sarcopenia in Older People criteria(all p<0.05),and only MVPA time was associated with lower likelihood of probable or confirmed sarcopenia(odds ratio=0.80,95%confidence interval:0.71-0.91 h/week).Similar associations were identified for total number of bouts,with no evidence of threshold effects for longer duration of bouts of MVPA.A total of 14%of participants reported-1 fall,but neither total time nor bouts of activity was associated with incident falls(all p>0.05).Conclusion:Higher amounts of accelerometer-determined MVPA are consistently associated with a decreased likelihood of sarcopenia and its components,regardless of the length of bouts or amounts of sedentary behavior.
文摘BACKGROUND The clinical presentation of gastroesophageal reflux disease(GERD) shows a large symptom variation also in different intensities among patients. As several studies have shown, there is a large overlap in the symptomatic spectrum between proven GERD and other disorders such as dyspepsia, functional heartburn and/or somatoform disorders.AIM To prospectively evaluate the GERD patients with and without somatoform disorders before and after laparoscopic antireflux surgery.METHODS In a tertiary referral center for foregut surgery over a period of 3 years patients with GERD, qualifying for the indication of laparoscopic antireflux surgery, were investigated prospectively regarding their symptomatic spectrum in order to identify GERD and associated somatoform disorders. Assessment of symptoms was performed by an instrument for the evaluation of somatoform disorders[Somatoform Symptom Index(SSI) > 17]. Quality of life was evaluated by Gastrointestinal Quality of Life Index(GIQLI).RESULTS In 123 patients an indication for laparoscopic antireflux surgery was established and in 43 patients further medical therapy was suggested. The portion of somatoform tendencies in the total patient population was 20.48%(34 patients).Patients with a positive SSI had a preoperative GIQLI of 77(32-111). Patients with a normal SSI had a GIQLI of 105(29-140)(P < 0.0001). In patients with GERD the quality of life could be normalized from preoperative reduced values of GIQLI102(47-140) to postoperative values of 117(44-144). In patients with GERD and somatoform disorders, the GIQLI was improved from preoperative GIQLI 75(47-111) to postoperative 95(44-122)(P < 0.0043).CONCLUSION Patients with GERD and associated somatoform disorders have significantly worse levels of quality of life. The latter patients can also benefit from laparoscopic fundoplication, however they will not reach a normal level.
文摘This article describes a technique that allows a photovoltaic (PV) production unit to obtain the maximum power at all times. Here, we use the MPPT control via fuzzy logic on a DC/DC boost-type converter. In order to achieve our goals, we first proceeded to model a PV panel. The resulting model offers the possibility to better account for the influence of different physical quantities such as temperature, irradiation, series resistance, shunt resistance and diode saturation current. Thus, the maximum power to be provided by the PV system is acquired by fuzzification and defuzzification of the input and output variables of the converter. Subsequently, a virtual model of an 800 Watt PV prototype is implemented in the Matlab environment. The simulation results obtained and presented, show the feasibility and efficiency of the proposed technology. Indeed, for a disturbance caused by a variation in brightness, our system guarantees the maximum stable power after 1.4</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">s. While for a load variation, the maximum power is continuous.
文摘Background:Cross-country skiing(XCS)racing,a popular international winter sport,is complex and challenging from physical,technical,and tactical perspectives.Despite the vast amount of research focusing on this sport,no review has yet addressed the pacing strategies of elite XCS racers or the factors that influence their performance.The aim was to review the scientific literature in an attempt to determine the effects of pacing strategy on the performance of elite XCS racers.Methods:Four electronic databases were searched using relevant subject headings and keywords.Only original research articles published in peerreviewed journals and the English language and addressing performance,biomechanics,physiology,and anthropometry of XCS racers were reviewed.Results:All 27 included articles applied correlative designs to study the effectiveness of different pacing strategies.None of the articles involved the use of an experimental design.Furthermore,potential changes in external conditions(e.g.,weather,ski properties)were not taken into consideration.A comparable number of studies focused on the skating or classical technique.In most cases,positive pacing was observed,with certain indications that higher-level athletes and those with more endurance and strength utilized a more even pacing strategy.The ability to achieve and maintain a long cycle length on all types of terrain was an important determinant of performance in all of the included studies,which was not the case for cycle rate.In general,uphill performance was closely related to overall race performance,with uphill performance being most closely correlated to the success of female skiers and performance on flat terrain being more important for male skiers.Moreover,pacing was coupled to the selection and distribution of technique during a race,with faster skiers employing more double poling and kick double poling,less diagonal stride,and more V2(double dance)than V1(single dance)skating across a race.Conclusion:We propose that skiers at all levels can improve their performance with more specific training in techniques(i.e.,maintaining long cycles without compromising cycle rate and selecting appropriate techniques)in combination with training for endurance and more strength.Furthermore,we would advise less experienced skiers and/or those with lower levels of performance to apply a more even pacing strategy rather than a positive one(i.e.,starting the race too fast).2018 Published by Elsevier B.V.on behalf of Shanghai University of Sport.This is an open access article under the CC BY-NC-ND license.(http://creativecommons.org/licenses/by-nc-nd/4.0/).
