Therapeutic agents used to treat glaucoma are designed to decrease the intra-ocular pressure (IOP) either by decreasing the aqueous humor production in the ciliary body and/or by enhancing the aqueous humor drainage f...Therapeutic agents used to treat glaucoma are designed to decrease the intra-ocular pressure (IOP) either by decreasing the aqueous humor production in the ciliary body and/or by enhancing the aqueous humor drainage from the eye. Oral carbonic an-hydrase inhibitors (CAIs) were the mainstay in the glaucoma therapy but of late, these agents have become less popular due展开更多
Cosmetics that are personal or personalized are now becoming extremely prevalent.While compliance is mandated by European Union(EU)Cosmetics Directive 1223/2009,there seem to be no strict guidelines for maintaining ob...Cosmetics that are personal or personalized are now becoming extremely prevalent.While compliance is mandated by European Union(EU)Cosmetics Directive 1223/2009,there seem to be no strict guidelines for maintaining obedience.Cosmetics must meet a number of conditions in order to be sold in the European Single Market;however,the focus of this article is on the Cosmetics Regulation 1223/2009.Regulations are examined for certain elements and several solutions are presented that allow for careful use of individually cloaked cosmetics that are available on the market.Metallic nanoparticles(NMs)have been proposed for usage as active ingredients/excipient in a number of cosmetics products.Due to fast-paced businesses in the cosmetic industry,cosmetology tends to focus on its distinctive characteristics to bring value to a diverse array of products,but due to the small size of nanometers,NMs may not always follow the very same handling guidelines as their conventional material.As a result,a nano-specific framework for regulating the use of nanomaterials&creation of nano-improved cosmetics is becoming increasingly prevalent.Scientific and industrial perspective into the NMs presently used for the m arketplace,with an emphasis on metallic NMs,and also an evaluation of the regulatory requirements and Scientific Commission on Consumer Safety(SCCS)Opinions.Considering the fact that the original Cosmetic products Directive(EU Legislation No 1223/2009)has precise restrictions on NMs,beauty materials containing unlawful NMs have already been supplied in the EU on numerous times.Researchers examine the risk evaluation indicated in Article 16 of the Cosmetology Code acts as a framework for the potential expansion to enhance nano-items,considering the long-term risks of nanomaterials if mistreated.The nation’s attention is on synchronizing efforts to integrate metallic NMs into cosmetic products but to the restricted fusion of metallic NMs with numerous non-metallic n anoparticles.Although Directive 76/768/EEC on the beauty items is an upright division of amendment that requires the European market for every cosmetic product placed to meet its exigencies would be irrational that it is for believings a stand-alone part of regulations is unaffected by other legal texts.In reality,D irective 76/768/EEC takes the form part of complicated legal action that began 40 years ago that ensure the free passage of goods throughout the EU while also European individuals’and their environment’s safety.The ongoing chapter outlines the most important aspects of the Directive Cosmetic Products along with the latest guidelines 2022 prepared by the COS law Team of what happened in the EU cosmetics regulatory framework between January and March,which serves as the book’s foundation.The trend of personal skincare seems to be high among clients.展开更多
Objective: Despite the fact that a restrictive use of episiotomy has proven to be beneficial, it continues to be widely used in vaginal births. Our aim was to compare women with episiotomy, to women with an intact per...Objective: Despite the fact that a restrictive use of episiotomy has proven to be beneficial, it continues to be widely used in vaginal births. Our aim was to compare women with episiotomy, to women with an intact perineum, 3 months after delivery, regarding several sexual variables, namely: sexual desire, arousal, orgasm, pain, sexual satisfaction and sexual function. Methods: An exploratory, descriptive and quantitative study using a non-probabilistic, convenience sample of 147 Portuguese women, of which 54 belonged to a control group, was performed. The groups were not significantly different regarding socio-demographic aspects. Three instruments were used: the Female Sexual Function Index, a Socio-demographic and Clinical Questionnaire and the Female Sexual Function Questionnaire. Results: Most women mentioned a moderate level of sexual interest. Women with episiotomy present higher pain intensity, less sexual satisfaction, greater changes regarding the orgasm’s duration and intensity, lower levels of sexual arousal and total sexual function, than women with intact perineum. Discussion: We found no significant differences between women with episiotomy and women with an intact perineum in most variables. However, women with episiotomy presented higher levels of pain and a lower sexual satisfaction, being these significant differences.展开更多
文摘Therapeutic agents used to treat glaucoma are designed to decrease the intra-ocular pressure (IOP) either by decreasing the aqueous humor production in the ciliary body and/or by enhancing the aqueous humor drainage from the eye. Oral carbonic an-hydrase inhibitors (CAIs) were the mainstay in the glaucoma therapy but of late, these agents have become less popular due
文摘Cosmetics that are personal or personalized are now becoming extremely prevalent.While compliance is mandated by European Union(EU)Cosmetics Directive 1223/2009,there seem to be no strict guidelines for maintaining obedience.Cosmetics must meet a number of conditions in order to be sold in the European Single Market;however,the focus of this article is on the Cosmetics Regulation 1223/2009.Regulations are examined for certain elements and several solutions are presented that allow for careful use of individually cloaked cosmetics that are available on the market.Metallic nanoparticles(NMs)have been proposed for usage as active ingredients/excipient in a number of cosmetics products.Due to fast-paced businesses in the cosmetic industry,cosmetology tends to focus on its distinctive characteristics to bring value to a diverse array of products,but due to the small size of nanometers,NMs may not always follow the very same handling guidelines as their conventional material.As a result,a nano-specific framework for regulating the use of nanomaterials&creation of nano-improved cosmetics is becoming increasingly prevalent.Scientific and industrial perspective into the NMs presently used for the m arketplace,with an emphasis on metallic NMs,and also an evaluation of the regulatory requirements and Scientific Commission on Consumer Safety(SCCS)Opinions.Considering the fact that the original Cosmetic products Directive(EU Legislation No 1223/2009)has precise restrictions on NMs,beauty materials containing unlawful NMs have already been supplied in the EU on numerous times.Researchers examine the risk evaluation indicated in Article 16 of the Cosmetology Code acts as a framework for the potential expansion to enhance nano-items,considering the long-term risks of nanomaterials if mistreated.The nation’s attention is on synchronizing efforts to integrate metallic NMs into cosmetic products but to the restricted fusion of metallic NMs with numerous non-metallic n anoparticles.Although Directive 76/768/EEC on the beauty items is an upright division of amendment that requires the European market for every cosmetic product placed to meet its exigencies would be irrational that it is for believings a stand-alone part of regulations is unaffected by other legal texts.In reality,D irective 76/768/EEC takes the form part of complicated legal action that began 40 years ago that ensure the free passage of goods throughout the EU while also European individuals’and their environment’s safety.The ongoing chapter outlines the most important aspects of the Directive Cosmetic Products along with the latest guidelines 2022 prepared by the COS law Team of what happened in the EU cosmetics regulatory framework between January and March,which serves as the book’s foundation.The trend of personal skincare seems to be high among clients.
文摘Objective: Despite the fact that a restrictive use of episiotomy has proven to be beneficial, it continues to be widely used in vaginal births. Our aim was to compare women with episiotomy, to women with an intact perineum, 3 months after delivery, regarding several sexual variables, namely: sexual desire, arousal, orgasm, pain, sexual satisfaction and sexual function. Methods: An exploratory, descriptive and quantitative study using a non-probabilistic, convenience sample of 147 Portuguese women, of which 54 belonged to a control group, was performed. The groups were not significantly different regarding socio-demographic aspects. Three instruments were used: the Female Sexual Function Index, a Socio-demographic and Clinical Questionnaire and the Female Sexual Function Questionnaire. Results: Most women mentioned a moderate level of sexual interest. Women with episiotomy present higher pain intensity, less sexual satisfaction, greater changes regarding the orgasm’s duration and intensity, lower levels of sexual arousal and total sexual function, than women with intact perineum. Discussion: We found no significant differences between women with episiotomy and women with an intact perineum in most variables. However, women with episiotomy presented higher levels of pain and a lower sexual satisfaction, being these significant differences.
