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Fiberoptic Intubation through Adapter Removable Supraglottic Airways;Comparison of the Air-Q ILA<sup>TM</sup>, LMA Classic Excel<sup>TM</sup>, and LMA Unique<sup>TM</sup>
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作者 Alvin Y. Lee Jonathan L. Benumof 《Open Journal of Anesthesiology》 2014年第5期111-118,共8页
Study Objective: We studied the overall efficacy of fiberoptic aided intubation using three different supraglottic airways (SGA) as intubation conduits with a standard endotracheal tube (ETT) to determine which, if an... Study Objective: We studied the overall efficacy of fiberoptic aided intubation using three different supraglottic airways (SGA) as intubation conduits with a standard endotracheal tube (ETT) to determine which, if any, is superior as an intubation conduit. Design: After induction of general anesthesia, subjects were randomized to one of three groups: Air-Q ILATM, LMA Classic ExcelTM, and LMA UniqueTM. Subjects were intubated with a fiberoptic aided technique with continuous ventilation with FiO2 = 1.0 through one of these SGAs. The primary endpoint was the overall efficacy of the intubation procedure. In addition, the following data were collected: demographic data, intubation times, grade of view of the larynx, and a visual analog scale (VAS) score of difficulty as determined by the primary anesthesiologist performing the procedure. Data were analyzed using a Kruskal-Wallis one-way analysis of variance and Post hoc analysis was done using Dunn’s Multiple Comparison Test. Results: 126 total subjects were studied. Intubation success rates were 100%, 87.8%, and 95% with the Air-Q ILATM, LMA Classic ExcelTM, and LMA UniqueTM respectively. There was no significant difference among the three different SGAs when comparing the times to place the SGA (T1), the true intubating time (T2), the time to remove the SGA (T3), or the total time (T4). Data were also stratified by the grade of view of the larynx;all grade I views, grade II views, and grade III views were grouped together regardless of the type of the SGA used. The grade I view of the larynx group had significantly faster true intubation times (T2 = 75.1 sec, p = 0.01) and significantly lower VAS scores (VAS = 1.9, P = TM provides the best view of the larynx and is the easiest one to use as an intubation conduit. 展开更多
关键词 Fiberoptic INTUBATION Laryngeal Mask AIRWAY SUPRAGLOTTIC AIRWAY
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波生坦加用吸入性treprostinil治疗肺动脉高压的安全性和有效性
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作者 Channick R.N. Olschewski H. +1 位作者 Seeger W. 郭俊 《世界核心医学期刊文摘(心脏病学分册)》 2007年第3期60-61,共2页
目的:评价口服波生坦加用吸入性treprostinil治疗肺动脉高压(PAH)患者的安全性和有效性。背景:在波生坦治疗PAH的同时通过吸入方式加用一种长效前列环素类似物可能是使治疗达到最佳化的安全有效的策略。
关键词 波生坦 肺动脉高压 TREPROSTINIL 前列环素类似物 肺血管阻力 平均肺动脉压 雾化吸入器
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肺动脉内膜剥脱术治疗慢性栓塞性肺动脉高压——UCSD32例手术经验 被引量:2
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作者 顾松 刘岩 +5 位作者 苏丕雄 翟振国 杨媛华 王辰 Michael M. Madani Stuart W. Jamieson 《中华胸心血管外科杂志》 CSCD 北大核心 2010年第4期232-235,共4页
目的 分析肺动脉内膜剥脱术(PEA)治疗慢性栓塞性肺动脉高压的围手术期资料,探讨美国加州大学圣迭戈分校(UCSD)手术经验.方法 回顾性研究UCSD 32例肺动脉血栓内膜剥脱手术资料,其中男17例,女15例;平均年龄(47.56±16.04)岁,平... 目的 分析肺动脉内膜剥脱术(PEA)治疗慢性栓塞性肺动脉高压的围手术期资料,探讨美国加州大学圣迭戈分校(UCSD)手术经验.方法 回顾性研究UCSD 32例肺动脉血栓内膜剥脱手术资料,其中男17例,女15例;平均年龄(47.56±16.04)岁,平均病程(3.90±4.61)年;15例有深静脉血栓病史.采用全麻、胸骨正中切口、深低温、间断停循环双侧肺动脉内膜剥脱的手术方法.结果 根据术中病理标本Jamieson分型,Ⅰ型占21.8%,Ⅱ型占28.1%,Ⅲ型占37.5%.平均转机(236.32±37.27)min,主动脉阻断(111.69±28.14)min,停循环(38.00±13.58)min.术后机械通气(66.23±99.24)h,住ICU(4.62±4.50)天,无死亡.病人肺动脉收缩压由术前(81.03±16.92)mm Hg(1 mm Hg=0.133 kPa)降至术后(51.20±12.16)mm Hg,肺血管阻力由术前(88.91±42.32)kPa·s·L-1降至术后的(34.38±15.68)kPa·s·L-1,心排量由术前(3.65±1.08)L/min增加到术后(5.85±1.21)L/min,中心静脉压由(13.07±2.11)cmH2O(1 cmH2O=0.098 kPa)降至(9.86±3.02)cmH2O.术后短期随访显示,病人心功能(NYHA)恢复到Ⅰ级19例、Ⅱ级13例,生活质量明显改善.结论 PEA是治疗慢性栓塞性肺动脉高压的重要手段,手术成功率逐年提高;深低温、间断停循环、双侧肺动脉内膜剥脱及内膜外翻技术为PEA标准术式.多中心资料证实该术式可以有效降低肺动脉压和肺血管阻力,明显改善血流动力学指标和心肺功能.多数国内医疗中心没有足够手术经验,应尽量避免选择肺动脉压收缩≥100mmHg,肺血管阻力≥100kPa·s·L^-1及Ⅲ型病变者行PEA手术. 展开更多
关键词 肺栓塞 动脉内膜切除术
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线粒体呼吸链复合体缺陷患者17例临床及病理特点 被引量:1
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作者 都爱莲 Richard Haas 《中华神经科杂志》 CAS CSCD 北大核心 2013年第7期458-460,共3页
线粒体病是一组各种原因引起的以线粒体氧化磷酸化功能受损为特征的遗传代谢性疾病。氧化磷酸化的正常功能有赖于线粒体内膜上5种复合物组成一个完整的复合体,任何一种复合物缺陷都可导致线粒体病,
关键词 线粒体呼吸链 复合体 病理特点 缺陷 线粒体氧化磷酸化 遗传代谢性疾病 临床 患者
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