This is the meeting report for the 2006 UCLA Center for East-West Medicine （CEWM） annual conference held at the UCLA Jules Stein auditorium on Saturday, October 28th. The event began with registration and a continen...This is the meeting report for the 2006 UCLA Center for East-West Medicine （CEWM） annual conference held at the UCLA Jules Stein auditorium on Saturday, October 28th. The event began with registration and a continental breakfast that allowed participants the opportunity to meet one another and discuss their experiences with integrative medicine. After the vips had checked-in and settled into the auditorium, Dr. Ka-Kit Hui, the Wallis Annenberg Professor in Integrative East West Medicine and the Founder and Director of the UCLA Center for East-West Medicine, introduced Dr. Alan Fogelman, Executive Chairman of the Department of Medicine, who gave opening remarks. Dr. Fogelman welcomed the audience, particularly the Center＇s distinguished vip - Professor Keji Chen, the Center＇s visiting professor of integrative medicine from China, emphasizing the importance of integrative medicine and praising the Center＇s leadership role in this field. Then Dr. Hui briefly introduced the audience to the field of integrative medicine, and discussed his own experience with integrative medicine and the history of the CEWM.展开更多
This well-documented uncontrolled study tracks improvement in the International Index of Erectile Function(IIEF)scores and penile curvature in 99 men with Peyronie's disease.^(1) It was conducted over the course o...This well-documented uncontrolled study tracks improvement in the International Index of Erectile Function(IIEF)scores and penile curvature in 99 men with Peyronie's disease.^(1) It was conducted over the course of two years and identified statistically significant improvement in penile curvature and erectile function with a tolerable complication rate in response to a tri-modal protocol of intralesional clostridium collagenase histolyticum(CCH),tadalafil,and vacuum treatment.Despite lack of controls,it does serve to confirm the safety,efficacy,and clinical utility of their nonsurgical approach and supports the growing body of literature on combined therapy for this difficult disorder.Based on results in multiple"real world"studies following the Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies(IMPRESS)Trial,^(2) it is encouraging to see that both chronic-and acute-phase patients were included.展开更多
Primary sellar atypical teratoid/rhabdoid tumor(AT/RT)is the most aggressive sellar mass.Although rare,sellar AT/RT exhibits a very relentless clinical course and usually results in death within months to a few years ...Primary sellar atypical teratoid/rhabdoid tumor(AT/RT)is the most aggressive sellar mass.Although rare,sellar AT/RT exhibits a very relentless clinical course and usually results in death within months to a few years after diagnosis.The best clinical evidence suggests that surgical debulking and timely adjuvant chemoradiation are most effective in prolonging survival.A preoperative radiological diagnosis of sellar AT/RT thus is crucial in informing patients and physicians about this devastating disease.This minireview summaries the imaging features of sellar AT/RT.magnetic resonance imaging features of sellar AT/RT and the much more common sellar mass,pituitary macroadenoma,are similar in most aspects:They are both isointense to brain gray matter on T1 and T2 imaging and enhance upon gadolinium administration.Suprasellar extension and cavernous sinus invasion are present in practically all cases of sellar AT/RT,but are also present in 50%-75%of pituitary macroadenomas,especially in large ones,suggesting that suprasellar extension and cavernous sinus invasion disproportionate to the tumor size may favor sellar AT/RT diagnosis.Since sellar AT/RT grows very rapidly and does not allow significant remodeling of perisellar structures,the imaging features of perisellar structures such as optic chiasm and cavernous sinus may be key for imaging diagnosis of sellar AT/RT although they have not been well described in sellar AT/RT.In limited cases of sellar AT/RT,optic chiasm degeneration and thinning,which are very common in pituitary macroadenoma,are not present,giving hope for using features of perisellar structures to diagnose sellar AT/RT by imaging.展开更多
Background:This study evaluated physical fitness and mental health in young and elderly women 3 months after mild COVID-19 infection,and examined the impact of infection and age on long COVID occurrence and trajectory...Background:This study evaluated physical fitness and mental health in young and elderly women 3 months after mild COVID-19 infection,and examined the impact of infection and age on long COVID occurrence and trajectory.Methods:There were 213 eligible female volunteers(107 young,106 elderly)recruited approximately three months after the significant outbreak of COVID-19 in China.Participants completed a fitness test and mental health assessment using the Post-Traumatic Stress Disorder Self-Assessment Scale(PTSD)and the Pittsburgh Sleep Quality Inventory(PSQI).Results:Despite no significant difference in physical fitness,infected young and elderly females experienced poorer sleep quality related to mental health compared to their uninfected peers(+22%in young participants,p=0.027;+10%in elderly participants,p=0.005).The elderly scored significantly higher in sleep quality than the young(p<0.05).Age,previous infection,and PTSD were significant predictors of sleep quality,explaining 60.6%of the variance in PSQI scores.Conclusions:Three months following COVID-19 infection,infected women experienced poorer sleep quality compared to their uninfected peers.Irrespective of being infected,older individuals exhibited higher rates of sleep disorders compared to younger women,suggesting the importance of addressing postCOVID-19 sleep issues among at-risk individuals.展开更多
Ribosomal RNA(rRNA)synthesis is intricately tied to cellular growth and proliferation.Basic fibroblast growth factor(FGF2),a pivotal factor for bone marrow mesenchymal stem cells(BMSCs),can stimulates rRNA transcripti...Ribosomal RNA(rRNA)synthesis is intricately tied to cellular growth and proliferation.Basic fibroblast growth factor(FGF2),a pivotal factor for bone marrow mesenchymal stem cells(BMSCs),can stimulates rRNA transcription,though the underlying mechanism remains unknown.Here,we demonstrate that the cytoplasm-nucleus translocation of FGF2 is determined by the stable nuclear localization motif.Meanwhile,the nuclear FGF2 regulates rRNA expression and BMSCs proliferation via phase separation.Next,through FGF2 related epigenomics and 3D genomes analysis,we identified chromatin architectures during BMSCs differentiation and aging.In the process,topologically associating domains(TADs)and chromatin loops profiling revealed the attenuated genomic interaction among proximal chromosomes 13,14,15,21,and 22,where phase-separated FGF2 facilitates rDNA transcription depend on specific super-enhancers(SEs).Furthermore,we validated that FGF2 orchestrates rDNA chromatin architecture in coordination with STAT5.Together,these findings underscore the pivotal role of FGF2 in rDNA chromatin architectures,which determines BMSCs cell fate.展开更多
提出一种河道细小线性水体自动识别方法。首先,利用全球30 m ASTER DEM数据,生成流域的水系分布矢量图;然后,以DEM水系分布图作为先验知识,通过空间分析形成信息提取目标区,为后续信息提取提供目标靶区;再次,通过水体光谱指数计算和NDW...提出一种河道细小线性水体自动识别方法。首先,利用全球30 m ASTER DEM数据,生成流域的水系分布矢量图;然后,以DEM水系分布图作为先验知识,通过空间分析形成信息提取目标区,为后续信息提取提供目标靶区;再次,通过水体光谱指数计算和NDWI全局阈值分割,得到靶区水体分布的初步信息;最后,在水体指数全域分割的基础上,通过局部水体指数物理特征分析、自适应阈值选择和迭代计算,实现局部河道水体精确提取。试验采用ETM+数据对伊犁河上游的支流河道进行信息提取,结果表明,该方法能够快速准确地完成大流域范围内的河道水系制图,并能够最大限度地降低细小河道水体识别中背景光谱信息混杂的干扰,提高遥感信息提取的针对性和计算的效率。展开更多
文摘This is the meeting report for the 2006 UCLA Center for East-West Medicine （CEWM） annual conference held at the UCLA Jules Stein auditorium on Saturday, October 28th. The event began with registration and a continental breakfast that allowed participants the opportunity to meet one another and discuss their experiences with integrative medicine. After the vips had checked-in and settled into the auditorium, Dr. Ka-Kit Hui, the Wallis Annenberg Professor in Integrative East West Medicine and the Founder and Director of the UCLA Center for East-West Medicine, introduced Dr. Alan Fogelman, Executive Chairman of the Department of Medicine, who gave opening remarks. Dr. Fogelman welcomed the audience, particularly the Center＇s distinguished vip - Professor Keji Chen, the Center＇s visiting professor of integrative medicine from China, emphasizing the importance of integrative medicine and praising the Center＇s leadership role in this field. Then Dr. Hui briefly introduced the audience to the field of integrative medicine, and discussed his own experience with integrative medicine and the history of the CEWM.
文摘This well-documented uncontrolled study tracks improvement in the International Index of Erectile Function(IIEF)scores and penile curvature in 99 men with Peyronie's disease.^(1) It was conducted over the course of two years and identified statistically significant improvement in penile curvature and erectile function with a tolerable complication rate in response to a tri-modal protocol of intralesional clostridium collagenase histolyticum(CCH),tadalafil,and vacuum treatment.Despite lack of controls,it does serve to confirm the safety,efficacy,and clinical utility of their nonsurgical approach and supports the growing body of literature on combined therapy for this difficult disorder.Based on results in multiple"real world"studies following the Investigation for Maximal Peyronie's Reduction Efficacy and Safety Studies(IMPRESS)Trial,^(2) it is encouraging to see that both chronic-and acute-phase patients were included.
文摘Primary sellar atypical teratoid/rhabdoid tumor(AT/RT)is the most aggressive sellar mass.Although rare,sellar AT/RT exhibits a very relentless clinical course and usually results in death within months to a few years after diagnosis.The best clinical evidence suggests that surgical debulking and timely adjuvant chemoradiation are most effective in prolonging survival.A preoperative radiological diagnosis of sellar AT/RT thus is crucial in informing patients and physicians about this devastating disease.This minireview summaries the imaging features of sellar AT/RT.magnetic resonance imaging features of sellar AT/RT and the much more common sellar mass,pituitary macroadenoma,are similar in most aspects:They are both isointense to brain gray matter on T1 and T2 imaging and enhance upon gadolinium administration.Suprasellar extension and cavernous sinus invasion are present in practically all cases of sellar AT/RT,but are also present in 50%-75%of pituitary macroadenomas,especially in large ones,suggesting that suprasellar extension and cavernous sinus invasion disproportionate to the tumor size may favor sellar AT/RT diagnosis.Since sellar AT/RT grows very rapidly and does not allow significant remodeling of perisellar structures,the imaging features of perisellar structures such as optic chiasm and cavernous sinus may be key for imaging diagnosis of sellar AT/RT although they have not been well described in sellar AT/RT.In limited cases of sellar AT/RT,optic chiasm degeneration and thinning,which are very common in pituitary macroadenoma,are not present,giving hope for using features of perisellar structures to diagnose sellar AT/RT by imaging.
文摘Background:This study evaluated physical fitness and mental health in young and elderly women 3 months after mild COVID-19 infection,and examined the impact of infection and age on long COVID occurrence and trajectory.Methods:There were 213 eligible female volunteers(107 young,106 elderly)recruited approximately three months after the significant outbreak of COVID-19 in China.Participants completed a fitness test and mental health assessment using the Post-Traumatic Stress Disorder Self-Assessment Scale(PTSD)and the Pittsburgh Sleep Quality Inventory(PSQI).Results:Despite no significant difference in physical fitness,infected young and elderly females experienced poorer sleep quality related to mental health compared to their uninfected peers(+22%in young participants,p=0.027;+10%in elderly participants,p=0.005).The elderly scored significantly higher in sleep quality than the young(p<0.05).Age,previous infection,and PTSD were significant predictors of sleep quality,explaining 60.6%of the variance in PSQI scores.Conclusions:Three months following COVID-19 infection,infected women experienced poorer sleep quality compared to their uninfected peers.Irrespective of being infected,older individuals exhibited higher rates of sleep disorders compared to younger women,suggesting the importance of addressing postCOVID-19 sleep issues among at-risk individuals.
基金the open research project of State Key Laboratory of Oral Diseases(no.SKLOD2024OF03)the Key Project of Natural Science Research in Anhui Provincial Universities(no.2024AH050683)+1 种基金Anhui Province Outstanding Young Teachers Development Program(no.YQYB2024013)the National Natural Science Foundation of China(no.82201026,82125006).
文摘Ribosomal RNA(rRNA)synthesis is intricately tied to cellular growth and proliferation.Basic fibroblast growth factor(FGF2),a pivotal factor for bone marrow mesenchymal stem cells(BMSCs),can stimulates rRNA transcription,though the underlying mechanism remains unknown.Here,we demonstrate that the cytoplasm-nucleus translocation of FGF2 is determined by the stable nuclear localization motif.Meanwhile,the nuclear FGF2 regulates rRNA expression and BMSCs proliferation via phase separation.Next,through FGF2 related epigenomics and 3D genomes analysis,we identified chromatin architectures during BMSCs differentiation and aging.In the process,topologically associating domains(TADs)and chromatin loops profiling revealed the attenuated genomic interaction among proximal chromosomes 13,14,15,21,and 22,where phase-separated FGF2 facilitates rDNA transcription depend on specific super-enhancers(SEs).Furthermore,we validated that FGF2 orchestrates rDNA chromatin architecture in coordination with STAT5.Together,these findings underscore the pivotal role of FGF2 in rDNA chromatin architectures,which determines BMSCs cell fate.
文摘提出一种河道细小线性水体自动识别方法。首先,利用全球30 m ASTER DEM数据,生成流域的水系分布矢量图;然后,以DEM水系分布图作为先验知识,通过空间分析形成信息提取目标区,为后续信息提取提供目标靶区;再次,通过水体光谱指数计算和NDWI全局阈值分割,得到靶区水体分布的初步信息;最后,在水体指数全域分割的基础上,通过局部水体指数物理特征分析、自适应阈值选择和迭代计算,实现局部河道水体精确提取。试验采用ETM+数据对伊犁河上游的支流河道进行信息提取,结果表明,该方法能够快速准确地完成大流域范围内的河道水系制图,并能够最大限度地降低细小河道水体识别中背景光谱信息混杂的干扰,提高遥感信息提取的针对性和计算的效率。
