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Genome-wide association study in historical and contemporary U.S.winter wheats identifies heightreducing loci 被引量:2
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作者 Sintayehu D.Daba Priyanka Tyagi +1 位作者 Gina Brown-Guedira Mohsen Mohammadi 《The Crop Journal》 SCIE CAS CSCD 2020年第2期243-251,共9页
Plant height has been a major target for selection of high-yielding varieties in wheat.Two height-reducing loci(Rht-B1 and Rht-D1)have been widely used since the Green Revolution.However,these genes also negatively af... Plant height has been a major target for selection of high-yielding varieties in wheat.Two height-reducing loci(Rht-B1 and Rht-D1)have been widely used since the Green Revolution.However,these genes also negatively affect other agronomic traits such as kernel weight.Identifying alternative height-reducing loci could benefit wheat improvement.This study focused on the genetics of plant height in 260 historical and contemporary winter wheat accessions via genome-wide association studies using 38,693 single nucleotide polymorphism(SNP)markers generated through genotyping by sequencing,two Kompetitive Allele Specific Polymorphismmarkers,and phenotypic data recorded in two seasons(2016 and 2018).The 260 accessions showed wide variation in plant height.Most accessions developed after 1960 were shorter than earlier accessions.The broad-sense heritability for plant height was high(H2=0.82),whichwas also supported by a high correlation(r=0.82,P<0.0001)between heights from the two years.We detected a total of 16 marker–trait associations(MTAs)for plant height at–lg(P)≥4.0 on chromosomes 1A,2B,2D,3B,4D,5A,5D,6A,6B,7A,and 7D.We detected three of the MTAs(QPLH-2D,QPLH-4B.2,and QPLH-4D)consistently in individual-year and combined-year analyses.These MTAs individually explained 10%–16%of phenotypic variation.The heightreducing alleles at these threeMTAs appeared after 1960 and increased in frequency thereafter.Among the genes near these loci were gibberellic acid insensitive(GAI)and GRAS transcription factor(GIBBERELLIC-ACID INSENSITIVE(GAI),REPRESSOR of GAI(RGA),and SCARECROW(SCR)).The evidence from this study and previous reports suggests that QPLH-2D is Rht8.A gene encoding a GRAS transcription factor is located near QPLH-2D.Validation of the QPLH-2D locus and associated candidate genes awaits further study. 展开更多
关键词 GWAS Marker-trait associations Rht-B1 Rht-D1 CANDIDATE genes Position-dependent procedures
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Forests of West Virginia,U.S.A. and Shaanxi,China:a study in forest exploitation and recovery
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作者 Jack E.Coster 彭鸿 张秦岭 《Journal of Forestry Research》 SCIE CAS CSCD 2004年第1期49-54,J002-J003,共8页
A review of the period of unregulated exploitation of forests in the state of West Virginia (U.S.) and in Shaanxi Province, PRC was presented. Economic and ecological recovery from exploitation has been different in t... A review of the period of unregulated exploitation of forests in the state of West Virginia (U.S.) and in Shaanxi Province, PRC was presented. Economic and ecological recovery from exploitation has been different in the two regions due to basic differences in nature of the forest and in the degree and persistence of exploitive pressures. After a century since unregulated exploitation, West Virginia forests are well on the road to management for sustainability and conservation. Shaanxi's recovery from overuse and unregulated exploitation is less certain; forests are still in the early phases of ecological recovery there. Full recovery to a period of sustainability will take a century or longer. Suggestions are made for measures needed to enhance the forest recovery. Keywords Forests - Shaanxi - West Virginia - Central China - Forest exploitation - Recovery CLC number S754 Document code A Article ID 1007-662X(2004)01-0049-06 Foundation item: The project was sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (2002–2004) and Shaanxi Provincial Foreign Expert Bureau (2003).Biography: Jack E. Coster (1935-), male, professor of West Virginia University, Morgantown, West Virginia. U.S.A.Responsible editor: Song Funan 展开更多
关键词 FORESTS SHAANXI West Virginia Central China Forest exploitation RECOVERY
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FISH ASSEMBLAGE RESPONSES TO DIFFERENT SECONDARY CHANNEL DESIGNS IN THE LOWER MISSISSIPPI RIVER,U.S.A.:A TEMPLATE FOR RIVER RESTORATION
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作者 KAISER Joseph E. SMITH Shannon C.F. +1 位作者 SCHRAMM Jr.,HAROLD L. EGGLETON Michael A. 《水生生物学报》 CAS CSCD 北大核心 2018年第6期1089-1106,共18页
The lower Mississippi River(LMR) has been heavily modified for multiple human purposes such as navigation, flood control, and bank stabilization. However, the LMR simultaneously supports a diverse fish fauna that incl... The lower Mississippi River(LMR) has been heavily modified for multiple human purposes such as navigation, flood control, and bank stabilization. However, the LMR simultaneously supports a diverse fish fauna that includes recreational and commercial fisheries. Due to river training and diversion structures constructed during the past 80 years, the historic characteristics of the LMR have been drastically altered and have likely influenced fishes and fisheries in the system. One common restoration measure used throughout the LMR has been to "notch" wing-dike structures that close secondary(side) river channels. Dike notching allows year-round flows through secondary channels, which enhances habitat diversity and promotes biological productivity at the ecosystem scale. Although notching is presumed good for LMR fishes and other biota, few studies have examined its effects on fish assemblages. In this study, fish assemblages were sampled at seven LMR secondary channels spanning from river kilometer(rkm) 628(Louisiana-Mississippi, U.S.A.) upstream to rkm 1504(Missouri-Kentucky, U.S.A.). Four secondary channels were termed "permanent"(i.e.,with notched dikes) while three secondary channels were termed "temporary"(i.e., without notched dikes).Fishes were sampled by boat-mounted electrofishing conducted during falling and low stages from1995—1997. Fish assemblages differed between permanent and temporary secondary channels, and varied somewhat between falling and low stages. Gizzard shad(Dorosoma cepedianum), threadfin shad(D. petenense), and white bass(Morone chrysops) demonstrated consistent preferences for low-current conditions associated with temporary secondary channels. Conversely, blue catfish(Ictalurus furcatus), flathead catfish(Pylodictis olivaris), and freshwater drum(Aplodinotus grunniens) were more associated with permanent secondary channels. Future restoration strategies in the LMR should consider dike notching and resultant maintenance of permanent secondary channels in selected river reaches. However, temporary secondary channels also contain unique fish species, and also appear to be important sites of riverine primary production. Restoration strategies should consider a balance of both secondary channel types, which should support the greatest biodiversity for the LMR ecosystem. 展开更多
关键词 MISSISSIPPI RIVER SECONDARY channels DIKES Fish ASSEMBLAGES RIVER restoration RIVER rehabilitation
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Climate Change Adaptation for People and Nature:A Case Study from the U.S.Southwest
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作者 Patrick D.MCCARTHY 《Advances in Climate Change Research》 SCIE 2012年第1期22-37,共16页
In the U.S.Southwest,global climate change,acting in concert with extant stressors such as urbanization and over-allocation of water resources,is changing ecosystems in measureable and sometimes dramatic ways.Twenty-f... In the U.S.Southwest,global climate change,acting in concert with extant stressors such as urbanization and over-allocation of water resources,is changing ecosystems in measureable and sometimes dramatic ways.Twenty-first century projections indicate accelerating climate change and cascading ecological consequences.Effects observed to date include large-scale forest dieback,large and severe wildfires,and changes in the flow regimes of rivers and streams with attendant changes to riparian and aquatic ecosystems.Rising temperatures and changing precipitation patterns are pushing ecosystems across physiological and ecological thresholds,causing widespread mortality and,in some cases,major changes in composition,structure and function.These changes have prompted action by the conservation community to reduce the adverse effects of climate change.The Southwest Climate Change Initiative(SWCCI),a project led by The Nature Conservancy,works with local stakeholders in affected landscapes,reduces adverse impacts on ecological and social systems using scientific knowledge and practical tools.The Initiative has learned through practical experience that: 1) managers must embrace change and manage for resilience rather than resistance;2) strong local science-management partnerships are critical to effective adaptation planning and implementation;3) planners and managers must broaden the scope and accelerate the pace of conservation activities if ecosystem services are to be sustained;4) adaptation often does not require radically new or different management practices,rather,conservationists already have many of the tools they need;and 5) rapid documentation and widespread communication of methods and findings can build rapidly regional capacity for climate change adaptation.Our experience suggests that adaptation efforts can be effective if they are focused at the local scale;employ learning networks;and engage in ecosystem-based adaptation:the sustainable management,conservation and restoration of ecosystems so that they continue to provide the services that allow people to thrive in changing environments. 展开更多
关键词 climate change adaptation ecosystem-based adaptation ecological thresholds learning networks
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Hyperspectral Evaluation of <i>Venturia inaequalis</i>Management Using the Disease Predictive Model RIMpro in the Northeastern U.S.
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作者 Matthew Wallhead Heping Zhu Kirk Broders 《Agricultural Sciences》 2017年第12期1358-1371,共14页
Use of hyperspectral spectroradiometers allows for information on different light bands to be captured, allowing for identification of plant health status. Apple scab is the most important disease in the production of... Use of hyperspectral spectroradiometers allows for information on different light bands to be captured, allowing for identification of plant health status. Apple scab is the most important disease in the production of apples. RIMpro is a web-based decision support system (DDS) for orchardists that has the capacity to improve optimal fungicide application for the control of apple scab and has the potential to reduce the number of applications and thereby reduce input expenses. The objective of this study was to complete a hyperspectral assessment of apple leaves in order to evaluate the spectral characteristics of trees sprayed according to forecasted infection events from the DDS. No significant differences in visual assessments or vegetation indices were observed between conventionally treated leaves and leaves treated according to the DSS. In the first year of this study two fungicide treatments were eliminated, in the second one fungicide treatment was eliminated. This finding is important because it provides evidence that plant health status is similar between conventionally sprayed trees and trees on a DSS-guided reduced spray program. In addition, the use of spectroradiometers for assessing the efficacy of different fungicide programs was demonstrated. Finally, potassium bicarbonate tank-mixed with sulfur was confirmed to be an effective spray material for managing apple scab. By integrating the precise information provided by DSSs and the use of biorational pesticides, agricultural producers, service providers and educators are able to adapt climate change considerations and action-oriented decisions into pest management plans. 展开更多
关键词 Integrated PEST MANAGEMENT Decision Support System PATHOGENS FUNGICIDE Remote Sensing
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Immediate mandibular reconstruction of a u.s. navy seal with a free fibula flap following osteoradionecrosis with pathological fracture
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作者 Ferguson, B Caballero, H. Cole, S. Hatt, H. Bach, K. Douglas, T. Gallus, K. Laughlin, R. 《中国口腔颌面外科杂志》 CAS 2008年第B05期218-219,共2页
关键词 修复方法 整形技术 腓骨 放射性骨坏死
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The U.S. Return to the Asia-Pacific Region and the East China Sea and South China Sea Issues
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作者 Yuan Zheng 《和平与发展》 2012年第5期70-74,共5页
关键词 和平与发展 南中国海 东中国海 领土
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Personal View on Sino-U.S.‘Trust Deficit'
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作者 TaoWenzhao 《Contemporary International Relations》 2013年第2期37-46,共10页
The fundamental reason for Sino-U.S.'trust deficit' is the narrowing of the gap between the two countries' national strengths and the subsequent change in U.S.policy.Especially the U.S.involvement in marit... The fundamental reason for Sino-U.S.'trust deficit' is the narrowing of the gap between the two countries' national strengths and the subsequent change in U.S.policy.Especially the U.S.involvement in maritime disputes between China and her neighbors have further complicated bilateral relations.The two countries should make concerted efforts to improve cooperation and trust and seek to build a new type of great power relationship. 展开更多
关键词 信任 中国学者 报纸
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Forest Wetland Area and the Forest Sector Economy in the U.S. South
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作者 Frederick Cubbage Robert Abt +2 位作者 Ray Sheffield Curt Flather James Wickham 《Open Journal of Forestry》 2018年第3期409-428,共20页
This article reviews current data on forest wetlands and their economic contributions in the South, ranging from Texas to Virginia. Based on USDA Forest Service Forest Inventory and Analysis (FIA) data, the wetland ca... This article reviews current data on forest wetlands and their economic contributions in the South, ranging from Texas to Virginia. Based on USDA Forest Service Forest Inventory and Analysis (FIA) data, the wetland category comprised 17.7% of timber land area on all private and public lands in the South. This included 4.25 million ha of hydric sites;0.77 million ha mesic wet;9.55 million ha mesic, with only seasonal access;for a total of 14.57 million ha. The Natural Resource Inventory (NRI) for 2012 on private lands estimated that there were 14.71 million ha forested wetlands, which comprised 17.7% of all forested private forest area. The 2015 National Land Cover Data for the South estimated that there were 17.8 million ha of woody wetlands, which comprised 8% to 12% of the southern land area, and there were also 4.45 million ha of emergent herbaceous sites. About 10% of the southern timber forest sector would be based on harvests from wetland forests economy ($455 million per year), while the 17.7% of wetland land area would provide a proportional share of the annual nontimber forest products ($44 million) and payments for ecosystem services ($134 million). Wetlands also provide important nontimber forest products, and ecosystem services, which are beginning to develop active private and public markets. 展开更多
关键词 FOREST WETLANDS Area ECONOMICS VALUATION
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An Era Calling for a New-type Major Country Relationship Between China and the U.S.
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作者 ZHANG XUDONG 《China Today》 2015年第11期20-23,共4页
CHINESE President Xi Jinping and his U.S.counterpart Barack Obama resumed their round of meetings with their latest meeting at the end of September 2015.This was their third summit following their meetings at Sunnylan... CHINESE President Xi Jinping and his U.S.counterpart Barack Obama resumed their round of meetings with their latest meeting at the end of September 2015.This was their third summit following their meetings at Sunnylands,California and evening talks at Yingtai,Beijing.If the week President Nixon spent in China was"a week that changed the world,"then the week during which President Xi paid a state visit to the U.S.and attended UN conferences may be called"a week that will shape the future." 展开更多
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Forging paths together:The history of U.S.-China Track II Health Dialogue and the future of Chinese-American health communication
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作者 Qun Yan Mark McClellan +2 位作者 Gordon G Liu Stephen Orlins George Fu Gao 《hLife》 2025年第2期57-60,共4页
As two of the largest economies and countries in theworld,the People’sRepublic of China(China)and the United States of America(U.S.)both have enormous resources and innovative talents in a number of sectors.Cooperati... As two of the largest economies and countries in theworld,the People’sRepublic of China(China)and the United States of America(U.S.)both have enormous resources and innovative talents in a number of sectors.Cooperation between both sides will be hugely beneficial to the world population,and this is especially the case with healthcare.The U.S.-China Track II Dialogue on Healthcare was set up as a forum to discuss and engage ideas on this very topic.In this dialogue,Dr.Qun Yan,head of the hLife Editorial Office engages in a dialogue with Professor Mark McClellan,the Director of the Duke-Margolis Institute for Health Policy at Duke University and U.S.Co-Chair of the Track Ⅱ Dialogue on Healthcare,Professor Gordon G Liu,Professor at Peking University and the Dean of the PKU Institute for Global Health andDevelopment andCo-Organizer of the Track Ⅱ Dialogue,Mr.Stephen Orlins,President of the National Committee on U.S.-China Relations and a Co-Organizer of the Track Ⅱ Dialogue,and Professor George Fu Gao,Academician at the Chinese Academy of Sciences and formerDirector of the Chinese Center for Disease Control and Prevention.They discuss how and why the Track Ⅱ Dialogue was created,the successes and developments of the dialogues,and what the future of American-Chinese health collaboration looks like. 展开更多
关键词 ACADEMICIAN U.S. DIRECTOR
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U.S.Fentanyl Crisis:Place the Blame Where It Belongs
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作者 Anthony Moretti 《Beijing Review》 2025年第20期23-23,共1页
Whenever U.S.Presibent Donald Trump talks about the U.S.fentanyl crisis,he will especially blame China for causing it That rhetoric does not hold up to scrutiny.At the beginning of this century,almost 800 Americans di... Whenever U.S.Presibent Donald Trump talks about the U.S.fentanyl crisis,he will especially blame China for causing it That rhetoric does not hold up to scrutiny.At the beginning of this century,almost 800 Americans died from a fentanyl overdose.Fast forward to 2021.and more than 107,000 deaths were traced to the drug in that year alone.How is it possible that in roughly 20 years,the number of deaths had spiked over 13,000 percent?The answer is a complex one:Politicians are not interested in delivering such answers.Instead,they live in a world in which deflection and blaume generate headlines.And we know anytime a politician blames China that news covernage is soon to follow. 展开更多
关键词 DEATHS politicians FENTANYL china DEFLECTION CRISIS BLAME coverage
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硼酸锌处理的平行木片胶合木的户外抗白蚁性能 被引量:1
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作者 施松林 Emmanuel Laval +2 位作者 Kee Lung 李伟 李小鹰 《中国人造板》 2025年第2期12-18,共7页
在江苏省无锡市进行了为期15年的户外试验,考察了硼酸锌(ZB)处理的平行木片胶合木(PSL)样品的抗白蚁性能。试验样品分别为未处理、等效硼酸添加量(Boric Acid Equivalent,BAE)0.85%和1.72%的ZB处理PSL。结果显示,ZB处理的PSL样品具有良... 在江苏省无锡市进行了为期15年的户外试验,考察了硼酸锌(ZB)处理的平行木片胶合木(PSL)样品的抗白蚁性能。试验样品分别为未处理、等效硼酸添加量(Boric Acid Equivalent,BAE)0.85%和1.72%的ZB处理PSL。结果显示,ZB处理的PSL样品具有良好的抗白蚁性能,15年后仍具有一定效果;等效硼酸添加量0.85%和1.72%的ZB处理PSL样品的中B2O3和ZnO的保留率统计学上差异不显著,因此推荐剂量为0.85%。 展开更多
关键词 硼酸锌 抗白蚁性 平行木片胶合木
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La_(0.9)Pr_(0.1)Fe_(12)B_(6)合金中的磁相变、X射线衍射谱变化和磁热性能
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作者 陈湘 贺兵 《物理学报》 北大核心 2025年第21期294-306,共13页
为了明确La_(0.9)Pr_(0.1)Fe_(12)B_(6)合金的变磁相变属性和对应的晶体结构特征,以及伴随的磁热效应,本文研究了该合金在磁场诱导和温度诱导下的变磁相变过程及其对应的X射线衍射图谱(X-ray diffraction spectrum,XRD)变化,并对不同测... 为了明确La_(0.9)Pr_(0.1)Fe_(12)B_(6)合金的变磁相变属性和对应的晶体结构特征,以及伴随的磁热效应,本文研究了该合金在磁场诱导和温度诱导下的变磁相变过程及其对应的X射线衍射图谱(X-ray diffraction spectrum,XRD)变化,并对不同测量模式下磁热性能进行深入对比.结果表明,La_(0.9)Pr_(0.1)Fe_(12)B_(6)合金主相在低场升温过程中,温度诱导的磁相变顺序为反铁磁态→铁磁态→顺磁态;在等温磁化过程中,在不同温度区间呈现出了3种磁场诱导的变磁相变,即在低温时的两种反铁磁态(antiferromagnetic,AFM)与铁磁态(ferromagnetic,FM)之间的相变,以及高温的顺磁态(paramagnetic state,PM)与FM态之间的相变,且其对应的临界磁场(critical magnetic field,H_(C))比LaFe_(12)B_(6)母合金的低得多.零场和加场变温XRD图谱显示La_(0.9)Pr_(0.1)Fe_(12)B_(6)合金的主相在磁无序和有序态间的转变过程中,会伴随磁晶耦合现象,其结果是XRD图谱中除原有主相的衍射峰外,还会出现一些PM态下无法观察到的新衍射峰,并且其强度随着温度的降低或磁场的增大而增强.另外,在基于连续测量模式下的等温磁化数据所计算的磁熵变随温度变化曲线中,可在居里温度附近观察到因磁场诱导PM-FM一级变磁相变而导致的大磁熵变(ΔS_(M)),如在70 kOe的磁场下,在50 K附近的最大磁熵变可达19 J/(kg·K),相对制冷量约为589.1 J/kg.然而在同样的测量模式下,却没有观察到因AFM-FM变磁相变所期望的大磁熵变.但采用非连续测量模式,则同样观察到AFM-FM变磁相变过程伴随的大磁熵变,如在70 kOe的磁场下,8 K附近的最大磁熵变可达-12 J/(kg·K). 展开更多
关键词 La_(0.9)Pr_(0.1)Fe_(12)B_(6) 合金 磁相变 磁热效应 X 射线衍射谱
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Density dependence and weather drive dabbling duck spatiotemporal distributions and intercontinental migration
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作者 Benjamin Golas Diann J.Prosser +2 位作者 Andrew M.Ramey Paul Link Wayne E.Thogmartin 《Avian Research》 2025年第4期637-649,共13页
Understanding migratory waterfowl spatiotemporal distributions is important because,in addition to their economic and cultural value,wild waterfowl can be infectious reservoirs of highly pathogenic avian influenza vir... Understanding migratory waterfowl spatiotemporal distributions is important because,in addition to their economic and cultural value,wild waterfowl can be infectious reservoirs of highly pathogenic avian influenza virus(HPAIV).Waterfowl migration has been implicated in regional and intercontinental HPAIV dispersal,and predictive capabilities of where and when HPAIV may be introduced to susceptible spillover hosts would facilitate biosecurity and mitigation efforts.To develop forecasts for HPAIV dispersal,an improved understanding of how individual birds interact with their environment and move on a landscape scale is required.Using an agent-based modeling approach,we integrated individual-scale energetics,species-specific morphology and behavior,and landscape-scale weather and habitat data in a mechanistic stochastic framework to simulate Mallard(Anas platyrhynchos)and Northern Pintail(Anas acuta)annual migration across the Northern Hemisphere.Our model recreated biologically realistic migratory patterns using a first principles approach to waterfowl ecology,behavior,and physiology.Conducting a limited structural sensitivity analysis comparing reduced models to eBird Status and Trends in reference to the full model,we identified density dependence as the main factor influencing spring migration and breeding distributions,and wind as the main factor influencing fall migration and overwintering distributions.We show evidence of weather patterns in Northeast Asia causing significant intercontinental pintail migration to North America.By linking individual energetics to landscapescale processes,we identify key drivers of waterfowl migration while developing a predictive model responsive to daily weather patterns.This model paves the way for future waterfowl migration research predicting HPAIV transmission,climate change impacts,and oil spill effects. 展开更多
关键词 Agent based modeling Anas acuta Anas platyrhynchos Landscape ecology MALLARD MIGRATION PHYSIOLOGY Pintail WEATHER
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New ^(10)Be-^(26)Al isochron burial dating informs the Pliocene and Pleistocene evolution of the lower Colorado River, southwestern United States
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作者 Yeong Bae Seong Ryan Crow +3 位作者 P.Kyle House Keith Howard Cho-Hee Lee Byong Yong Yu 《Episodes》 2025年第1期51-63,共13页
Four new^(10)Be-^(26)Al isochron burial ages ranging from 4.4 to 2 Ma on ancestral Colorado River deposits in the lower Colorado River corridor(LCRC)help constrain the river’s evolution during the Pliocene and early ... Four new^(10)Be-^(26)Al isochron burial ages ranging from 4.4 to 2 Ma on ancestral Colorado River deposits in the lower Colorado River corridor(LCRC)help constrain the river’s evolution during the Pliocene and early Pleisto-cene.They help fill a gap between previous work that focused on older and younger deposits:Older dated deposits include the 5 Ma Bouse Formation,which records the integration of the Colorado River through a series of preexisting basins to the Gulf of California and the ca.4.5-3.5 Ma Bullhead Alluvium,a 200 to 300 m thick aggregational package that immediately followed integration.The much younger,100-70 ka,Chemehuevi Formation is another major aggrada-tion package mapped throughout the LCRC.The new burial ages on the facies of Santa Fe Railway(4.37±0.71 Ma),boulder conglomerate of Bat Cave Wash(2.12±0.26 and 2.05±0.31 Ma),and the Palo Verde alluvium(3.03±0.26 Ma)partially fill in a 3.5 M.y.gap between the deposition of the Bullhead Alluvium and the Chemeheuvi Formation and document the timescales over which the Colorado River was able to remove the Bullhead aggradational package and initiate newer and smaller aggradational pulses. 展开更多
关键词 be al isochron burial dating Lower Colorado River colorado river deposits southwestern United States bullhead al Santa Fe Railway PLEISTOCENE colorado river series preexisting basins
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Patriarchal Apparatus:The Role of Media,University,and Athletic ISAs in the Nassar Abuse Case
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作者 A.Paige Frazier 《Journalism and Mass Communication》 2025年第4期209-215,共7页
The Larry Nassar scandal at Michigan State University is the worst and most widespread case of childhood sex abuse in this nation’s history to date,affecting over 150 young girls and women.This article asks:What were... The Larry Nassar scandal at Michigan State University is the worst and most widespread case of childhood sex abuse in this nation’s history to date,affecting over 150 young girls and women.This article asks:What were the structural and ideological mechanisms,policies,and practices that enabled this widespread abuse over a thirty-year period?Louis Althusser’s Marxist theory of Ideological State Apparatuses(and feminist responses to this theory)is useful in explaining how state-making institutions-media outlets,universities,athletic organizations,and family units-are not only produced and reproduced along class lines,but also with respect to gendered power dynamics.By examining the patriarchal nature of ISAs,one can begin to understand how Larry Nassar was for so long shielded from suspicion and criminal prosecution by the institutions that employed him. 展开更多
关键词 structural mechanisms ideological mechanisms feminist responses patriarchal nature criminal prosecution
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境外已上市原研药在中国注册必要临床试验现状分析
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作者 葛永彬 楼长刚 +1 位作者 董剑平 邵亚光 《中国食品药品监管》 2025年第11期22-33,共12页
本研究通过规范研究与实证分析相结合的方法,系统分析了化学药品5.1类和治疗用生物制品3.1类在我国的临床试验要求现状。通过对2016~2024年获批的341个化学药品5.1类和99个治疗用生物制品3.1类的注册数据分析发现:约50%以上的两类药品... 本研究通过规范研究与实证分析相结合的方法,系统分析了化学药品5.1类和治疗用生物制品3.1类在我国的临床试验要求现状。通过对2016~2024年获批的341个化学药品5.1类和99个治疗用生物制品3.1类的注册数据分析发现:约50%以上的两类药品需要通过常规临床试验路径获批,即在中国开展完整的临床试验;通过桥接试验或豁免临床路径获批的药品,也分别有约75%和60%以上需要开展上市后研究。从临床开发时间看,化学药品5.1类从关键临床试验开始到申请上市的平均用时为861天,超过化学药品1类的679天;治疗用生物制品3.1类为618天,与治疗用生物制品1类的617天基本相当。研究表明,化学药品5.1类和治疗用生物制品3.1类在我国承担了与1类创新药相当甚至更重的临床试验负担,建议考虑在知识产权和数据保护、监管标准国际化、参比制剂管理等方面建立更加平衡的制度体系,促进创新药物的及时可及。 展开更多
关键词 化学药品5.1类 治疗用生物制品3.1类 临床试验 药品注册 知识产权保护 数据保护期
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