Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors,serving to supply nutrients and oxygen,and remove metabolic wastes. Kaposi’s sarcoma (KS),a multifocal angioproliferative disorder characterize...Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors,serving to supply nutrients and oxygen,and remove metabolic wastes. Kaposi’s sarcoma (KS),a multifocal angioproliferative disorder characterized by spindle cell proliferation,neo-angiogenesis,inflammation,and edema,is associated with infection by Kaposi's sarcoma-associated herpesvirus (KSHV). Recent studies indicate that KSHV infection directly promotes angiogenesis and inflammation through an autocrine and paracrine mechanism by inducing pro-angiogenic and pro-inflammatory cytokines. Many of these cytokines are also expressed in KS lesions,implicating a direct role of KSHV in the pathogenesis of this malignancy. Several KSHV genes are involved in KSHV-induced angiogenesis. These studies have provided insights into the pathogenesis of KS,and identified potential therapeutic targets for this malignancy.展开更多
MicroRNAs (miRNAs) play important roles in eukaryotes,plants and some viruses. It is increasingly clear that miRNAs-encoded by viruses can affect the viral life cycle and host physiology. Viral miRNAs could repress th...MicroRNAs (miRNAs) play important roles in eukaryotes,plants and some viruses. It is increasingly clear that miRNAs-encoded by viruses can affect the viral life cycle and host physiology. Viral miRNAs could repress the innate and adaptive host immunity,modulate cellular signaling pathways,and regulate the expression of cellular and viral genes. These functions facilitate viral acute and persistent infections,and have profound effects on the host cell survival and disease progression. Here,we discuss the miRNAs encoded by herpesviruses,and their regulatory roles involved in virus-host interactions.展开更多
基金The Knowledge Innovation Program of the Chinese Academy of Sciences Chinese Academy of Sciences (0702121YJ1)Open Research Fund Program of the State Key Laboratory of Virology of China (2007013)+1 种基金A Type B Outstanding Abroad Young Scientist Award (30328001) from the National Science Foundation of Chinagrants from the National Institutes of Health (CA096512,CA124332,CA119889 and DE017333)
文摘Tumor angiogenesis is the uncontrolled growth of blood vessels in tumors,serving to supply nutrients and oxygen,and remove metabolic wastes. Kaposi’s sarcoma (KS),a multifocal angioproliferative disorder characterized by spindle cell proliferation,neo-angiogenesis,inflammation,and edema,is associated with infection by Kaposi's sarcoma-associated herpesvirus (KSHV). Recent studies indicate that KSHV infection directly promotes angiogenesis and inflammation through an autocrine and paracrine mechanism by inducing pro-angiogenic and pro-inflammatory cytokines. Many of these cytokines are also expressed in KS lesions,implicating a direct role of KSHV in the pathogenesis of this malignancy. Several KSHV genes are involved in KSHV-induced angiogenesis. These studies have provided insights into the pathogenesis of KS,and identified potential therapeutic targets for this malignancy.
基金The Knowledge Innovation Program of the Chinese Academy of Sciences Chinese Academy of Sciences (0702121YJ1)Open Research Fund Program of the State Key Laboratory of Virology of China(2007013)+1 种基金National Science Foundation of China (A Type B Outstanding Abroad Young Scientist Award)National Institutes of Health (CA096512,CA124332,CA119889 and DE017333)
文摘MicroRNAs (miRNAs) play important roles in eukaryotes,plants and some viruses. It is increasingly clear that miRNAs-encoded by viruses can affect the viral life cycle and host physiology. Viral miRNAs could repress the innate and adaptive host immunity,modulate cellular signaling pathways,and regulate the expression of cellular and viral genes. These functions facilitate viral acute and persistent infections,and have profound effects on the host cell survival and disease progression. Here,we discuss the miRNAs encoded by herpesviruses,and their regulatory roles involved in virus-host interactions.
