Objective:To investigate the effects of a dry aqueous extract of Notobasis syriaca(N.syriaca)on lipopolysaccharide(LPS)-induced inflammation in rats.Methods:Rats were fed the dried extract[500 mg/(kg·d)]for three...Objective:To investigate the effects of a dry aqueous extract of Notobasis syriaca(N.syriaca)on lipopolysaccharide(LPS)-induced inflammation in rats.Methods:Rats were fed the dried extract[500 mg/(kg·d)]for three consecutive days and then were intraperitoneally injected with LPS(1 mg/kg).Two hours after LPS injection,rats were sacrificed and blood and brain regions were collected.Inflammatory mediators'levels in plasma and homogenates of brain regions were determined by ELISA.Results:Pretreatment with the N.syriaca extract resulted in significant anti-inflammatory effects(P<0.05),including:(i)attenuated LPS-induced hypothermia;(ii)decreased hypothalamus and hippocampus prostaglandin E_(2)levels in the LPStreated rats;and,(iii)reduced hypothalamus and hippocampus interleukin-6 and tumor necrosis factor-a levels in the LPS-treated rats.Conclusions:These results suggest that N.syriaca possesses anti-inflammatory properties.Thus,it is possible that long-term consumption of this plant may result in beneficial pharmacological effects.展开更多
文摘Objective:To investigate the effects of a dry aqueous extract of Notobasis syriaca(N.syriaca)on lipopolysaccharide(LPS)-induced inflammation in rats.Methods:Rats were fed the dried extract[500 mg/(kg·d)]for three consecutive days and then were intraperitoneally injected with LPS(1 mg/kg).Two hours after LPS injection,rats were sacrificed and blood and brain regions were collected.Inflammatory mediators'levels in plasma and homogenates of brain regions were determined by ELISA.Results:Pretreatment with the N.syriaca extract resulted in significant anti-inflammatory effects(P<0.05),including:(i)attenuated LPS-induced hypothermia;(ii)decreased hypothalamus and hippocampus prostaglandin E_(2)levels in the LPStreated rats;and,(iii)reduced hypothalamus and hippocampus interleukin-6 and tumor necrosis factor-a levels in the LPS-treated rats.Conclusions:These results suggest that N.syriaca possesses anti-inflammatory properties.Thus,it is possible that long-term consumption of this plant may result in beneficial pharmacological effects.
