AIM: To evaluate if canine models are appropriate for teaching endoscopy fellows the techniques of endoscopic submucosal dissection (ESD). METHODS: ESD was performed in 10 canine models under general anesthesia, on ar...AIM: To evaluate if canine models are appropriate for teaching endoscopy fellows the techniques of endoscopic submucosal dissection (ESD). METHODS: ESD was performed in 10 canine models under general anesthesia, on artificial lesions of the esophagus or stomach marked with coagulation points. After ESD, each canine model was euthanized and surgical resection of the esophagus or stomach was carried out according to "The Principles of Humane Experimental Technique, Russel and Burch". The ESD specimens were fixed with needles on cork submerged in a formol solution with the esophagus or stomach, and delivered to the pathology department to be analyzed. RESULTS: ESD was completed without complications using the Hook-knife in five esophageal areas, with a procedural duration of 124 ± 19 min, a length of 27.4 ± 2.6 mm and a width of 21 ± 2.4 mm. ESD was also completed without complications using the IT-knife2 in five gastric areas, with a procedural duration of 92.6 ± 19 min, a length of 32 ± 2.5 mm and a width of 18 ± 3.7 mm. CONCLUSION: ESD is feasible in the normal esopha- gus and stomach of canine models, which are appropriate for teaching this technique.展开更多
BACKGROUND Chronic atrophic gastritis(CAG)is a clinically refractory gastric disease often characterized by high recurrence rates and adverse drug reactions.Anwei decoction(AWD),a traditional Chinese medicine formula,...BACKGROUND Chronic atrophic gastritis(CAG)is a clinically refractory gastric disease often characterized by high recurrence rates and adverse drug reactions.Anwei decoction(AWD),a traditional Chinese medicine formula,has been shown to significantly improve clinical symptoms in patients with CAG,as demonstrated by a multicenter cohort study(overall effective rate:82.5%,P<0.01).However,the unclear molecular mechanisms and therapeutic targets of AWD limit its international acceptance.AIM To investigate the therapeutic mechanisms of AWD against CAG from an integrated perspective.METHODS In this study,N-methyl-N’-nitro-N-nitrosoguanidine was used to establish a CAG rat model.Serum-derived constituents transferred from AWD were first identified using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.The concentrations of inflammatory cytokines in serum samples were determined by enzyme-linked immunosorbent assay.Moreover,gastric mucosal tissues were analyzed by quantitative realtime polymerase chain reaction to measure messenger RNA(mRNA)levels of the NLRP3 inflammasome.Western blotting was used to detect the protein expression of NLRP3,caspase-1,and interleukin(IL)-1β.To elucidate the regulatory mechanisms underlying AWD treatment,structural alterations of the gut microbiota(GM)and associated metabolites were analyzed using integrated high-throughput sequencing(16S rRNA)and liquid chromatography-mass spectrometry based untargeted metabolomics.This comprehensive approach systematically clarified AWD’s multi-target therapeutic mechanisms against CAG.RESULTS AWD notably reduced serum levels of pro-inflammatory cytokines,such as IL-1β,IL-18,tumor necrosis factor-α,and lipopolysaccharide,demonstrating significant statistical differences(all P<0.01).Additionally,AWD substantially inhibited NLRP3 mRNA expression in gastric mucosal tissue(P<0.01)and concurrently decreased the protein abundance of NLRP3,IL-1β,and caspase-1(all P<0.01),thereby suppressing inflammasome signaling activation.GM analysis indicated that AWD intervention significantly increased the relative abundance of beneficial bacteria.Associated microbial metabolites likely inhibited the NLRP3 inflammasome pathway by modulating immune cell function.Non-targeted metabolomics further indicated that AWD exerted anti-inflammatory effects by regulating critical metabolic pathways,including the Kaposi’s sarcoma-associated herpesvirus infection pathway,autophagy processes,and glycosylphosphatidylinositol-anchor biosynthesis.CONCLUSION AWD alleviates the pathological progression of CAG through multi-target synergistic mechanisms.On one hand,AWD directly suppresses gastric mucosal inflammation by inhibiting NLRP3 inflammasome activation.On the other hand,AWD remodels intestinal microbiota-metabolite homeostasis,enhances intestinal barrier function,and regulates mucosal immune responses.展开更多
Managing memory deficits is a central problem among older adults with mild cognitive impairment (MCI). This study examined the effects of memory training on memory performance in an understudied “oldest-old” populat...Managing memory deficits is a central problem among older adults with mild cognitive impairment (MCI). This study examined the effects of memory training on memory performance in an understudied “oldest-old” population ranging in age from 90 to 99 years. Eighteen mild to moderately cognitive-impaired older seniors, 90 years and older were recruited from memory clinics established in senior living communities. Treatment sessions took place, on average, twice weekly, for 55 minutes. Memory intervention included nineteen computer-based exercises customized to focus on memory loss. The specificity of memory training was very clear;memory training produced significant effects (F(3,51) = 2.81, p = 0.05) on memory performance, especially after 6 months of training, while other outcome measures showed no effects as predicted. Based on the results, it can be concluded that interventions targeting cognition and memory in the oldest-old MCI population can significantly improve memory function and reduce cognitive deficits.展开更多
In order to meet the training needs of Partial Discharge (PD) detection personnel, a PD detection training simulator is developed. The composition of the system and the functions of the modules are described, then the...In order to meet the training needs of Partial Discharge (PD) detection personnel, a PD detection training simulator is developed. The composition of the system and the functions of the modules are described, then the three-dimensional graphic engine based on Open Scene Graph (OSG) and the way of scene organization based on hierarchical tree are introduced, moreover, the methods of fault simulation and detection instrument simulation based on algorithm component library are presented. Application shows that the system can provide various detection schemes, and it is an ideal training tool for the detection personnel.展开更多
With deep development of state grid’s system of "Three Sets of Five [1]", China is in urgent need of establishing an appropriate type of simulation system to rapidly improve operation efficiency and the lev...With deep development of state grid’s system of "Three Sets of Five [1]", China is in urgent need of establishing an appropriate type of simulation system to rapidly improve operation efficiency and the level of maintainers, which aim at the integrated operation of substation operation and maintenance service. This article gives an introduction of a simulation training system which is designed for operation-skills training in electrical systems. By the composition of the multiple subjects and skills training for operations staff, this system can provide human guarantee and intellectual support for the "Big-Centralized Overhal".展开更多
Background: Low back pain is the most common spinal disorder among soldiers, and load carriage training(LCT) is considered the main cause. We aimed to investigate changes in the spine system of soldiers after LCT at h...Background: Low back pain is the most common spinal disorder among soldiers, and load carriage training(LCT) is considered the main cause. We aimed to investigate changes in the spine system of soldiers after LCT at high altitudes and the change trend of the lumbar spine and surrounding soft tissues under different load conditions.Methods: Magnetic resonance imaging scans of the lumbar spines of nine soldiers from plateau troops were collected and processed. We used ImageJ and Surgimap software to analyze changes in the lumbar paraspinal muscles, intervertebral discs(IVDs), intervertebral foramina, and curvature. Furthermore, the multiple linear regression equation for spine injury owing to LCT at high altitudes was established as the mathematical prediction model using SPSS Statistics version 23.0 software.Results: In the paraspinal muscles, the cross-sectional area(CSA) increased significantly from(9126.4±691.6) mm~2 to(9862.7±456.4) mm~2, and the functional CSA(FCSA) increased significantly from(8089.6±707.7) mm~2 to(8747.9±426.2) mm~2 after LCT(P<0.05);however, the FCSA/CSA was not significantly different. Regarding IVD, the total lumbar spine showed a decreasing trend after LCT with a significant difference(P<0.05). Regarding the lumbar intervertebral foramen, the percentage of the effective intervertebral foraminal area of L3/4 significantly decreased from 91.6%±2.0% to 88.1%±2.9%(P<0.05). For curvature, the lumbosacral angle after LCT(32.4°±6.8°) was significantly higher(P<0.05) than that before LCT(26.6°±5.3°), while the lumbar lordosis angle increased significantly from(24.0°±7.1°) to(30.6°±7.4°)(P<0.05). The linear regression equation of the change rate, ΔFCSA%=–0.718+23.085×load weight, was successfully established as a prediction model of spinal injury after LCT at high altitudes.Conclusion: The spinal system encountered increased muscle volume, muscle congestion, tissue edema, IVD compression, decreased effective intervertebral foramen area, and increased lumbar curvature after LCT, which revealed important pathophysiological mechanisms of lumbar spinal disorders in soldiers following short-term and high-load weight training. The injury prediction model of the spinal system confirmed that a load weight <60% of soldiers' weight cannot cause acute pathological injury after short-term LCT, providing a reference supporting the formulation of the load weight standard for LCT.展开更多
AIM:To evaluate the effect of hands-on training of gastroenterology fellows in gastric polypectomy using an ex vivo simulator.METHODS:Eight gastroenterology fellows at Mackay Memorial Hospital,Taipei were evaluated in...AIM:To evaluate the effect of hands-on training of gastroenterology fellows in gastric polypectomy using an ex vivo simulator.METHODS:Eight gastroenterology fellows at Mackay Memorial Hospital,Taipei were evaluated in gastricpolypectomy techniques using a pig stomach with artificial polyps created by a rubber band ligation device.The performance of four second year(year-2)fellows who had undergone one year of clinical training was compared with that of four f irst year(year-1)fellows both before and after a 4-h workshop using the ex vivo simulator.The workshop allowed for hands-on train-ing in the removal of multiple artif icial polyps and the placement of hemoclips at the excision site.Evaluation included observation of technical skills,procedure time,and the fellows' conf idence scale.RESULTS:One week after the workshop,the year-1 fellows were re-evaluated and had significantly im-proved mean performance scores(from 17.9 ± 1.8 to 22.5 ± 0.7),conf idence scale(from 4.5 ± 1.0 to 7.8 ± 0.5)and procedure time(from 615.0 ± 57.4 s to 357.5 ± 85.0 s)compared with their baseline performance.After 4 h of training using the ex vivo simulator,the skills of the year-1 fellows were statistically similar to those of the year-2 fellows.CONCLUSION:Use of this ex vivo simulator significantly improved the endoscopic gastric polypectomy skills of gastroenterology fellows who had not had previous clinical training in gastric polypectomy.展开更多
The effects of a memory training paradigm on performance across multiple cognitive domains, measured via the Cognistat, in 70 - 89 year-old individuals with mild cognitive impairment (MCI), were examined. Memory train...The effects of a memory training paradigm on performance across multiple cognitive domains, measured via the Cognistat, in 70 - 89 year-old individuals with mild cognitive impairment (MCI), were examined. Memory training sessions were conducted on average twice weekly, for 55 minutes each session, for 9 months. Across the testing period, Cognistat-measured memory increased relative to performance in other cognitive domains. Additionally, performance on non-memory measures remained stable or declined. Thus, memory training in older adult, MCI individuals may result in improved memory, but not in improvement in other, non-memory, cognitive domains. Results replicate previous work examining “oldest-old” individuals ranging in age from 90 to 99 years old at the time of study start.展开更多
Subjective memory impairment is a major complaint among older adults;however, research is conflicting regarding the relationship between subjective memory impairment and objectively measured memory loss. Here, individ...Subjective memory impairment is a major complaint among older adults;however, research is conflicting regarding the relationship between subjective memory impairment and objectively measured memory loss. Here, individuals with mild memory impairment completed the memory subscale of the Cognistat as a measure of objective memory, and the Memory Complaint Questionnaire (MCQ) as a measure of subjective memory, prior to and following a 3-month memory training program. Results revealed that individuals with more, compared with fewer, memory complaints performed worse on the Cognistat. Additionally, increased Cognistat performance fol-lowing the memory training procedure was associated with decreased MCQ measured complaints. There was suggestive evidence that the memory training procedure improved memory, and thus future research is warranted. These findings imply that older, memory-impaired, adults, despite their memory impairment, are indeed able to judge, and may be accurately concerned with, the extent of their own memory loss. It should be noted that serious statistical limitations here indicate the need for replication to confirm the validity of the findings.展开更多
The article presents wide experience in controlling athletic training aimed at preparation of the Russian national teams for major international competitions. Experimental part of the study has been carried out in the...The article presents wide experience in controlling athletic training aimed at preparation of the Russian national teams for major international competitions. Experimental part of the study has been carried out in the course of training camps and competitions since 2010. Forty Russian national teams in 15 winter and 3 summer Olympic sports participated in the research. Theoretical concepts set forth in the works of Anthony Stafford Beer made a basis of a system of control and management developed for the Russian national winter sports teams. In particular, a five-level system was applied to control athletic training. The authors point out that a system of control over athletic training in elite sport teams should take into account a few important issues： （1） each sport, team and athlete has distinctive features; （2） various aspects of athletic training and their interrelation must be aimed at raising effectiveness of training according to individual training plans; （3） coaches and sport managers must be provided with real-time information necessary for development of long-term and short-term training plans and their timely correction.展开更多
Introduction: The key to successful elimination of tuberculosis (TB) is treatment of cases with optimum chemotherapy. Irrational anti-TB drug use over time has led to drug-resistant TB. The treatment of MDR-TB with se...Introduction: The key to successful elimination of tuberculosis (TB) is treatment of cases with optimum chemotherapy. Irrational anti-TB drug use over time has led to drug-resistant TB. The treatment of MDR-TB with second line drugs is long, complex and costly, and has a considerable rate of adverse effects. The level of ADR reporting is low in Ethiopia due to different factors. This Study conducted in a selected treated area in Addis Ababa, Ethiopia and helped the health care centers to understand the prevalence of ADR related MDR-TB and be aware of those adverse effects in order to detect them early and be prepared to take proper steps when they occur. Aim of the Study: To determine the prevalence and risk factor of adverse drug reactions associated treatments of Multidrug Resistant tuberculosis. Method: This was a cross sectional study, which was conducted between March 2012 and February 2013 at St. Peter TB specialized hospital and AHRI/ALERT. 73 MDR TB patients, who were on MDR TB treatments, enrolled to the study. Adverse Drug Reactions associated MDR TB treatments were assessed by patient history review and questionnaire. Chemistry laboratory was used to test renal function, thyroid function, liver enzyme and potassium level. Result: In 72 patients, at least two ADRs were found. The mean age of the study population (Mean ± SD) was 28 ± 8.8. In this study the most commonly found adverse drug reactions (ADRs) were: Anorexia 83.3%, Nausea and vomiting 82%, Gastritis 64%, Arteralgia 47%, Skin rash and itching 45%, Headache 29.2%, Depression 22.2% and Blurred vision 19.4%. Using binary logistic regression model older age (COR 8.71, 95% [CI] 1.06 - 71.9), alcoholism (COR 4.05, 95% [CI] 1.05 - 15.6), smoking (COR 0.24, 95% [CI] 0.06 - 0.87) and concomitant drug intake (COR 0.14, 95% [CI] 0.03 - 0.76) were independent predictors for ADRs. Conclusion: The prevalence of ADRs related MDR TB treatments is high. To minimize ADR occurrence, ADR predictors should be integrated into the clinical pathway. Monitoring of liver function, renal function, TSH and level of potassium during MDR TB treatment, helps to avoid complication caused by therapy and increase the adherence to the treatment.展开更多
AIM: To investigate the use of the Gaumard's Noelle S550.100 Maternal and Neonatal Simulators for teaching forceps delivery.METHODS: Twenty two(n = 22) resident physicians were enrolled in a simulation course on o...AIM: To investigate the use of the Gaumard's Noelle S550.100 Maternal and Neonatal Simulators for teaching forceps delivery.METHODS: Twenty two(n = 22) resident physicians were enrolled in a simulation course on operative forceps deliveries. The physicians enrolled in the course were all part of an accredited Obstetrics and Gynecology residency program and ranged in their training from post graduate year(PGY) 1-4. Each participant received simulation based teaching on the indications, contraindications, proper application, delivery and removal of forceps by a single teacher. The Gaumard's simulator and Simpson forceps were used for this course. Statistical analysis using SPSS statistical software was performed after the completion of the simulation training program. A paired student t-test was performed to compare the cohort's mean pretest and post simulation training scores. Follow up skills assessment scores at one month, 3 mo and 6 mo were compared to thebaseline pretest score using a paired student t-test. RESULTS: There was statistically significant improvement in the post simulation training performance evaluations compared to the pretest, 13.7(SD = 3.14) vs 7.9(SD = 4.92), P < 0.05. Scores at 1 mo, 3 mo, and 6 mo were compared to the pretest score and showed retention of skills: 4.6(SD = 5.5, 95%CI: 2.21-7.07), 4.4(SD = 5.2, 95%CI: 2.13-6.70), and 5.6(SD = 4.8, 95%CI: 3.53-7.75) points, respectively. There were statistically significant differences between residents by post graduate training year on pretest scores, however these differences were not present after simulation training. Pretest scores for PGY 1, 2, 3, 4 were 3.5(SD = 2.27, 95%CI: 2.13-5.00), 7.25(SD = 6.70, 95%CI: 1.50-13.00), 10.75(SD = 1.5, 95%CI: 9.50-12.00), 12.17(SD = 2.57, 95%CI: 10.33-14.00). After simulation training PGY 1 residents did as well as well as the upper level residents. Posttest mean test scores for PGY 1, 2, 3, 4 were 13.75(SD = 1.49, 95%CI: 12.75-14.63), 10.25(SD = 0.24, 95%CI: 4.25-14.00), 15.00(SD = 1.16, 95%CI: 14.00-16.00), 15.17(SD = 0.75, 95%CI: 14.67-15.67). CONCLUSION: Our simulation based training program not only produced short term gains, but participants were able to retain the skills learned and demonstrate their knowledge months later.展开更多
Background: While causing a financial and economic loss in many countries in a few months, COVID 19 was of great impact on public health. The Iraqi government took several measures since the first Iraqi case was disco...Background: While causing a financial and economic loss in many countries in a few months, COVID 19 was of great impact on public health. The Iraqi government took several measures since the first Iraqi case was discovered in February 2020. One of the fundamental measures to control this pandemic is social isolation, which depends greatly on people’s awareness to decrease the incidence of COVID-19. Objectives: To study the COVID-19-effect on dentists’ social life and their future plan, and to find the relation between that effect and some dentists’ demographic variables. Methods: A cross-sectional study was conducted from 2nd January to 7th May 2021, by an electronic version of the questionnaire through Google form. With facilitating orders delivered to all the specialist dental centers for adults of Al-Resafa health directorate;any dentists working in specialist dental centers for adults of Al-Resafa health directorate, and accept to participate in this study. Results: A total of 10 specialist dental centers for adults of the Al-Resafa health directorate represent 566/628 dentists enrolled in this study with a response rate of 88.99%. Most of them aged less than 30 years old (62.2%), female (60.6%), married status (50.4%), had 1 - 3 children (71.91%), Rotator (51.1%), with less than five years of experience (61.3%). Conclusion: COVID-19 affected so many aspects of health workers’ lives including dentists. About two-thirds of dentists had negative feelings, of which almost all had anxiety. Younger ages, females, married and having children are factors that contribute to the affection of dental social lives more than other categories.展开更多
Implement the innovation of the ＂apprenticeship＂ training method in the teachers, explore the effective ways of cultivating the young teachers and the transferred teachers, determine the guidance teachers and the tr...Implement the innovation of the ＂apprenticeship＂ training method in the teachers, explore the effective ways of cultivating the young teachers and the transferred teachers, determine the guidance teachers and the training objects through the combination of rec- ommendation and self-recommendation, sign the mentoring agreement, establish the scientific and effective assessment and incentive mechanisms, to promote the healthy growth of the groups of teachers and the orderly cohesion the replacement of the old and new teachers.展开更多
We performed a retrospective analysis of 9 patients with acute myeloid leukemia (AML) treated with gemtuzumab ozogamicin (GO) plus cytarabine as a salvage regimen (GO reinduction) for patients who did not achieve comp...We performed a retrospective analysis of 9 patients with acute myeloid leukemia (AML) treated with gemtuzumab ozogamicin (GO) plus cytarabine as a salvage regimen (GO reinduction) for patients who did not achieve complete remission (CR) after the first cycle of induction chemotherapy or at first relapse. Cases of AML secondary to myelodysplastic syndrome or myeloproliferative disorder were included. CR was achieved in 6 of 9 patients, and 2 of 6 responders became long-term survivors. No non-responders survived longer than 6 months. Toxicity was mild, and the median duration of myelosuppression was less than 30 days. Stomatitis, nausea and sepsis occurred as non-hematological adverse events. Although our sample size was too small to permit definitive conclusions, GO reinduction should be considered for patients who relapse or do not achieve CR after the first cycle of induction chemotherapy. Some AML subtypes may respond more robustly than others, and further investigation is warranted.展开更多
"No danger is safe, no lack is complete." Safety in production is an insurmountable red bottom line for every enterprise. The guarantee of safety in production lies in both material factors and human factors..."No danger is safe, no lack is complete." Safety in production is an insurmountable red bottom line for every enterprise. The guarantee of safety in production lies in both material factors and human factors. The most important and basic part of this factor is safety education. Safety education and training are in place, safety education knowledge is effectively instilled, and the content and carrier of safety education and training are practical, which is both the foundation and the focus. Therefore, it is necessary to establish a safety education and training mechanism in order to maintain the orderly development of the production and operation of enterprises. Only effective safety education, training and training methods break through the traditional mode, can employees carry out safety production based on their posts, and protecting themselves is one of the important factors of safety.展开更多
Safe production is the focus of various management works in power generation enterprises, the foundation for further development of power enterprises and the cornerstone for power enterprises to obtain economic benefi...Safe production is the focus of various management works in power generation enterprises, the foundation for further development of power enterprises and the cornerstone for power enterprises to obtain economic benefits. The safety of electricity production is directly related to the stability of social development and people's practical interests. In recent years, the situation of production safety in power enterprises has become increasingly severe. In order to improve the management level of production safety, power enterprises must strengthen the management of production safety and fundamentally improve the management level of production safety. This paper studies and analyzes the work of safety education and training for reference.展开更多
Introduction: Postpartum mental disorders are psychopathological states that affect women after childbirth. These disorders often negatively impact a child’s mental health and the mother-child bond. The objective of ...Introduction: Postpartum mental disorders are psychopathological states that affect women after childbirth. These disorders often negatively impact a child’s mental health and the mother-child bond. The objective of this work was to determine the frequency of mental disorders during the postpartum period at the University Community Health Center of Konobougou in Mali. Methods: This descriptive cross-sectional study took place from March 1 to July 31, 2022, for four months. Results: The study involved 201 immediate postpartum women at the Konobougou Community and University Health Center. The 20-35 age group accounted for 70.00% of the population;the average age was 24 years ± 5.95 years, with a range of 15 to 45 years. Married women made up 96.00% of the sample. The overall frequency of mental disorders was 15.92%. The mental disorders recorded were postpartum depression (5.47%), anxiety disorders (3.98%), postpartum blues (5.47%), and posttraumatic stress disorder (0.50%). Puerperal psychosis was found in 0.50% of the participants. Conclusion: This study revealed a high prevalence of mental disorders among postpartum women in Konobougou, Mali. During postnatal consultations, health workers should prioritize screening for mental health disorders.展开更多
BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility disturbance.The pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling p...BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility disturbance.The pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal cells.Moreover,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal cells.Cajal cells are the pacemakers of gastrointestinal motility.AIM To investigate the effects of Bifidobacterium lactis(B.lactis)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit pathway.METHODS The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 days.The tail group was given B.lactis BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/day.Hematoxylin&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and PCR.The fecal flora and mucosal flora of rats in each group were detected by 16S rRNA.RESULTS Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic intervention.Simulated microgravity reduced the expressions of SCF and c-kit,and increased the expressions of ERK and P-ERK in the gastric antrum of rats.However,after probiotic intervention,the expressions of SCF and ckit were increased,while the expressions of ERK and P-ERK were decreased,with statistical significance(P<0.05).In addition,simulated microgravity can reduce the operational taxonomic unit(OTU)of the overall intestinal flora of rats,B.lactis BLa80 can increase the OTU of rats,simulated microgravity can reduce the overall richness and diversity of stool flora of rats,increase the abundance of firmicutes in stool flora of rats,and reduce the abundance of Bacteroides in stool flora of rats,most of which are mainly beneficial bacteria.Simulated microgravity can increase the overall richness and diversity of mucosal flora,increase the abundance of Bacteroides and Desulphurides in the rat mucosal flora,and decrease the abundance of firmicutes,most of which are proteobacteria.After probiotics intervention,the overall Bacteroidetes trend in simulated microgravity rats was increased.CONCLUSION B.lactis BLa80 can ameliorate intestinal mucosal injury,regulate intestinal flora,inhibit ERK expression,and activate the SCF/c-kit signaling pathway,which may have a facilitating effect on gastrointestinal motility in simulated microgravity rats.展开更多
7075 aluminum alloy is often used as an important load-bearing structure in aircraft industry due to its superior mechanical properties.During the process of deep hole boring,the boring bar is prone to vibrate because...7075 aluminum alloy is often used as an important load-bearing structure in aircraft industry due to its superior mechanical properties.During the process of deep hole boring,the boring bar is prone to vibrate because of its limited machining space,bad environment and large elongation induced low stiffness.To reduce vibration and improve machined surface quality,a particle damping boring bar,filled with particles in its inside damping block,is designed based on the theory of vibration control.The theoretical damping coefficient is determined,then the boring bar structure is designed and trial-manufactured.Experimental studies through impact testing show that cemented carbide particles with a diameter of 5 mm and a filling rate of 70% achieve a damping ratio of 19.386%,providing excellent vibration reduction capabilities,which may reduce the possibility of boring vibration.Then,experiments are setup to investigate its vibration reduction performance during deep hole boring of 7075 aluminum alloy.To observe more obviously,severe working conditions are adopted and carried out to acquire the time domain vibration signal of the head of the boring bar and the surface morphologies and roughness values of the workpieces.By comparing different experimental results,it is found that the designed boring bar could reduce the maximum vibration amplitude by up to 81.01% and the surface roughness value by up to 47.09% compared with the ordinary boring bar in two sets of experiments,proving that the designed boring bar can effectively reduce vibration.This study can offer certain valuable insights for the machining of this material.展开更多
文摘AIM: To evaluate if canine models are appropriate for teaching endoscopy fellows the techniques of endoscopic submucosal dissection (ESD). METHODS: ESD was performed in 10 canine models under general anesthesia, on artificial lesions of the esophagus or stomach marked with coagulation points. After ESD, each canine model was euthanized and surgical resection of the esophagus or stomach was carried out according to "The Principles of Humane Experimental Technique, Russel and Burch". The ESD specimens were fixed with needles on cork submerged in a formol solution with the esophagus or stomach, and delivered to the pathology department to be analyzed. RESULTS: ESD was completed without complications using the Hook-knife in five esophageal areas, with a procedural duration of 124 ± 19 min, a length of 27.4 ± 2.6 mm and a width of 21 ± 2.4 mm. ESD was also completed without complications using the IT-knife2 in five gastric areas, with a procedural duration of 92.6 ± 19 min, a length of 32 ± 2.5 mm and a width of 18 ± 3.7 mm. CONCLUSION: ESD is feasible in the normal esopha- gus and stomach of canine models, which are appropriate for teaching this technique.
基金Supported by the National Natural Science Foundation of China,No.81860843Guangxi Administration of Traditional Chinese Medicine Project,No.GZSY23-36 and No.GXZYA20240150。
文摘BACKGROUND Chronic atrophic gastritis(CAG)is a clinically refractory gastric disease often characterized by high recurrence rates and adverse drug reactions.Anwei decoction(AWD),a traditional Chinese medicine formula,has been shown to significantly improve clinical symptoms in patients with CAG,as demonstrated by a multicenter cohort study(overall effective rate:82.5%,P<0.01).However,the unclear molecular mechanisms and therapeutic targets of AWD limit its international acceptance.AIM To investigate the therapeutic mechanisms of AWD against CAG from an integrated perspective.METHODS In this study,N-methyl-N’-nitro-N-nitrosoguanidine was used to establish a CAG rat model.Serum-derived constituents transferred from AWD were first identified using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.The concentrations of inflammatory cytokines in serum samples were determined by enzyme-linked immunosorbent assay.Moreover,gastric mucosal tissues were analyzed by quantitative realtime polymerase chain reaction to measure messenger RNA(mRNA)levels of the NLRP3 inflammasome.Western blotting was used to detect the protein expression of NLRP3,caspase-1,and interleukin(IL)-1β.To elucidate the regulatory mechanisms underlying AWD treatment,structural alterations of the gut microbiota(GM)and associated metabolites were analyzed using integrated high-throughput sequencing(16S rRNA)and liquid chromatography-mass spectrometry based untargeted metabolomics.This comprehensive approach systematically clarified AWD’s multi-target therapeutic mechanisms against CAG.RESULTS AWD notably reduced serum levels of pro-inflammatory cytokines,such as IL-1β,IL-18,tumor necrosis factor-α,and lipopolysaccharide,demonstrating significant statistical differences(all P<0.01).Additionally,AWD substantially inhibited NLRP3 mRNA expression in gastric mucosal tissue(P<0.01)and concurrently decreased the protein abundance of NLRP3,IL-1β,and caspase-1(all P<0.01),thereby suppressing inflammasome signaling activation.GM analysis indicated that AWD intervention significantly increased the relative abundance of beneficial bacteria.Associated microbial metabolites likely inhibited the NLRP3 inflammasome pathway by modulating immune cell function.Non-targeted metabolomics further indicated that AWD exerted anti-inflammatory effects by regulating critical metabolic pathways,including the Kaposi’s sarcoma-associated herpesvirus infection pathway,autophagy processes,and glycosylphosphatidylinositol-anchor biosynthesis.CONCLUSION AWD alleviates the pathological progression of CAG through multi-target synergistic mechanisms.On one hand,AWD directly suppresses gastric mucosal inflammation by inhibiting NLRP3 inflammasome activation.On the other hand,AWD remodels intestinal microbiota-metabolite homeostasis,enhances intestinal barrier function,and regulates mucosal immune responses.
文摘Managing memory deficits is a central problem among older adults with mild cognitive impairment (MCI). This study examined the effects of memory training on memory performance in an understudied “oldest-old” population ranging in age from 90 to 99 years. Eighteen mild to moderately cognitive-impaired older seniors, 90 years and older were recruited from memory clinics established in senior living communities. Treatment sessions took place, on average, twice weekly, for 55 minutes. Memory intervention included nineteen computer-based exercises customized to focus on memory loss. The specificity of memory training was very clear;memory training produced significant effects (F(3,51) = 2.81, p = 0.05) on memory performance, especially after 6 months of training, while other outcome measures showed no effects as predicted. Based on the results, it can be concluded that interventions targeting cognition and memory in the oldest-old MCI population can significantly improve memory function and reduce cognitive deficits.
文摘In order to meet the training needs of Partial Discharge (PD) detection personnel, a PD detection training simulator is developed. The composition of the system and the functions of the modules are described, then the three-dimensional graphic engine based on Open Scene Graph (OSG) and the way of scene organization based on hierarchical tree are introduced, moreover, the methods of fault simulation and detection instrument simulation based on algorithm component library are presented. Application shows that the system can provide various detection schemes, and it is an ideal training tool for the detection personnel.
文摘With deep development of state grid’s system of "Three Sets of Five [1]", China is in urgent need of establishing an appropriate type of simulation system to rapidly improve operation efficiency and the level of maintainers, which aim at the integrated operation of substation operation and maintenance service. This article gives an introduction of a simulation training system which is designed for operation-skills training in electrical systems. By the composition of the multiple subjects and skills training for operations staff, this system can provide human guarantee and intellectual support for the "Big-Centralized Overhal".
基金supported by the National Key Research and Development Program of China (2018YFB1307603)the National Natural Science Foundation of China (8174100706)。
文摘Background: Low back pain is the most common spinal disorder among soldiers, and load carriage training(LCT) is considered the main cause. We aimed to investigate changes in the spine system of soldiers after LCT at high altitudes and the change trend of the lumbar spine and surrounding soft tissues under different load conditions.Methods: Magnetic resonance imaging scans of the lumbar spines of nine soldiers from plateau troops were collected and processed. We used ImageJ and Surgimap software to analyze changes in the lumbar paraspinal muscles, intervertebral discs(IVDs), intervertebral foramina, and curvature. Furthermore, the multiple linear regression equation for spine injury owing to LCT at high altitudes was established as the mathematical prediction model using SPSS Statistics version 23.0 software.Results: In the paraspinal muscles, the cross-sectional area(CSA) increased significantly from(9126.4±691.6) mm~2 to(9862.7±456.4) mm~2, and the functional CSA(FCSA) increased significantly from(8089.6±707.7) mm~2 to(8747.9±426.2) mm~2 after LCT(P<0.05);however, the FCSA/CSA was not significantly different. Regarding IVD, the total lumbar spine showed a decreasing trend after LCT with a significant difference(P<0.05). Regarding the lumbar intervertebral foramen, the percentage of the effective intervertebral foraminal area of L3/4 significantly decreased from 91.6%±2.0% to 88.1%±2.9%(P<0.05). For curvature, the lumbosacral angle after LCT(32.4°±6.8°) was significantly higher(P<0.05) than that before LCT(26.6°±5.3°), while the lumbar lordosis angle increased significantly from(24.0°±7.1°) to(30.6°±7.4°)(P<0.05). The linear regression equation of the change rate, ΔFCSA%=–0.718+23.085×load weight, was successfully established as a prediction model of spinal injury after LCT at high altitudes.Conclusion: The spinal system encountered increased muscle volume, muscle congestion, tissue edema, IVD compression, decreased effective intervertebral foramen area, and increased lumbar curvature after LCT, which revealed important pathophysiological mechanisms of lumbar spinal disorders in soldiers following short-term and high-load weight training. The injury prediction model of the spinal system confirmed that a load weight <60% of soldiers' weight cannot cause acute pathological injury after short-term LCT, providing a reference supporting the formulation of the load weight standard for LCT.
文摘AIM:To evaluate the effect of hands-on training of gastroenterology fellows in gastric polypectomy using an ex vivo simulator.METHODS:Eight gastroenterology fellows at Mackay Memorial Hospital,Taipei were evaluated in gastricpolypectomy techniques using a pig stomach with artificial polyps created by a rubber band ligation device.The performance of four second year(year-2)fellows who had undergone one year of clinical training was compared with that of four f irst year(year-1)fellows both before and after a 4-h workshop using the ex vivo simulator.The workshop allowed for hands-on train-ing in the removal of multiple artif icial polyps and the placement of hemoclips at the excision site.Evaluation included observation of technical skills,procedure time,and the fellows' conf idence scale.RESULTS:One week after the workshop,the year-1 fellows were re-evaluated and had significantly im-proved mean performance scores(from 17.9 ± 1.8 to 22.5 ± 0.7),conf idence scale(from 4.5 ± 1.0 to 7.8 ± 0.5)and procedure time(from 615.0 ± 57.4 s to 357.5 ± 85.0 s)compared with their baseline performance.After 4 h of training using the ex vivo simulator,the skills of the year-1 fellows were statistically similar to those of the year-2 fellows.CONCLUSION:Use of this ex vivo simulator significantly improved the endoscopic gastric polypectomy skills of gastroenterology fellows who had not had previous clinical training in gastric polypectomy.
文摘The effects of a memory training paradigm on performance across multiple cognitive domains, measured via the Cognistat, in 70 - 89 year-old individuals with mild cognitive impairment (MCI), were examined. Memory training sessions were conducted on average twice weekly, for 55 minutes each session, for 9 months. Across the testing period, Cognistat-measured memory increased relative to performance in other cognitive domains. Additionally, performance on non-memory measures remained stable or declined. Thus, memory training in older adult, MCI individuals may result in improved memory, but not in improvement in other, non-memory, cognitive domains. Results replicate previous work examining “oldest-old” individuals ranging in age from 90 to 99 years old at the time of study start.
文摘Subjective memory impairment is a major complaint among older adults;however, research is conflicting regarding the relationship between subjective memory impairment and objectively measured memory loss. Here, individuals with mild memory impairment completed the memory subscale of the Cognistat as a measure of objective memory, and the Memory Complaint Questionnaire (MCQ) as a measure of subjective memory, prior to and following a 3-month memory training program. Results revealed that individuals with more, compared with fewer, memory complaints performed worse on the Cognistat. Additionally, increased Cognistat performance fol-lowing the memory training procedure was associated with decreased MCQ measured complaints. There was suggestive evidence that the memory training procedure improved memory, and thus future research is warranted. These findings imply that older, memory-impaired, adults, despite their memory impairment, are indeed able to judge, and may be accurately concerned with, the extent of their own memory loss. It should be noted that serious statistical limitations here indicate the need for replication to confirm the validity of the findings.
文摘The article presents wide experience in controlling athletic training aimed at preparation of the Russian national teams for major international competitions. Experimental part of the study has been carried out in the course of training camps and competitions since 2010. Forty Russian national teams in 15 winter and 3 summer Olympic sports participated in the research. Theoretical concepts set forth in the works of Anthony Stafford Beer made a basis of a system of control and management developed for the Russian national winter sports teams. In particular, a five-level system was applied to control athletic training. The authors point out that a system of control over athletic training in elite sport teams should take into account a few important issues： （1） each sport, team and athlete has distinctive features; （2） various aspects of athletic training and their interrelation must be aimed at raising effectiveness of training according to individual training plans; （3） coaches and sport managers must be provided with real-time information necessary for development of long-term and short-term training plans and their timely correction.
文摘Introduction: The key to successful elimination of tuberculosis (TB) is treatment of cases with optimum chemotherapy. Irrational anti-TB drug use over time has led to drug-resistant TB. The treatment of MDR-TB with second line drugs is long, complex and costly, and has a considerable rate of adverse effects. The level of ADR reporting is low in Ethiopia due to different factors. This Study conducted in a selected treated area in Addis Ababa, Ethiopia and helped the health care centers to understand the prevalence of ADR related MDR-TB and be aware of those adverse effects in order to detect them early and be prepared to take proper steps when they occur. Aim of the Study: To determine the prevalence and risk factor of adverse drug reactions associated treatments of Multidrug Resistant tuberculosis. Method: This was a cross sectional study, which was conducted between March 2012 and February 2013 at St. Peter TB specialized hospital and AHRI/ALERT. 73 MDR TB patients, who were on MDR TB treatments, enrolled to the study. Adverse Drug Reactions associated MDR TB treatments were assessed by patient history review and questionnaire. Chemistry laboratory was used to test renal function, thyroid function, liver enzyme and potassium level. Result: In 72 patients, at least two ADRs were found. The mean age of the study population (Mean ± SD) was 28 ± 8.8. In this study the most commonly found adverse drug reactions (ADRs) were: Anorexia 83.3%, Nausea and vomiting 82%, Gastritis 64%, Arteralgia 47%, Skin rash and itching 45%, Headache 29.2%, Depression 22.2% and Blurred vision 19.4%. Using binary logistic regression model older age (COR 8.71, 95% [CI] 1.06 - 71.9), alcoholism (COR 4.05, 95% [CI] 1.05 - 15.6), smoking (COR 0.24, 95% [CI] 0.06 - 0.87) and concomitant drug intake (COR 0.14, 95% [CI] 0.03 - 0.76) were independent predictors for ADRs. Conclusion: The prevalence of ADRs related MDR TB treatments is high. To minimize ADR occurrence, ADR predictors should be integrated into the clinical pathway. Monitoring of liver function, renal function, TSH and level of potassium during MDR TB treatment, helps to avoid complication caused by therapy and increase the adherence to the treatment.
文摘AIM: To investigate the use of the Gaumard's Noelle S550.100 Maternal and Neonatal Simulators for teaching forceps delivery.METHODS: Twenty two(n = 22) resident physicians were enrolled in a simulation course on operative forceps deliveries. The physicians enrolled in the course were all part of an accredited Obstetrics and Gynecology residency program and ranged in their training from post graduate year(PGY) 1-4. Each participant received simulation based teaching on the indications, contraindications, proper application, delivery and removal of forceps by a single teacher. The Gaumard's simulator and Simpson forceps were used for this course. Statistical analysis using SPSS statistical software was performed after the completion of the simulation training program. A paired student t-test was performed to compare the cohort's mean pretest and post simulation training scores. Follow up skills assessment scores at one month, 3 mo and 6 mo were compared to thebaseline pretest score using a paired student t-test. RESULTS: There was statistically significant improvement in the post simulation training performance evaluations compared to the pretest, 13.7(SD = 3.14) vs 7.9(SD = 4.92), P < 0.05. Scores at 1 mo, 3 mo, and 6 mo were compared to the pretest score and showed retention of skills: 4.6(SD = 5.5, 95%CI: 2.21-7.07), 4.4(SD = 5.2, 95%CI: 2.13-6.70), and 5.6(SD = 4.8, 95%CI: 3.53-7.75) points, respectively. There were statistically significant differences between residents by post graduate training year on pretest scores, however these differences were not present after simulation training. Pretest scores for PGY 1, 2, 3, 4 were 3.5(SD = 2.27, 95%CI: 2.13-5.00), 7.25(SD = 6.70, 95%CI: 1.50-13.00), 10.75(SD = 1.5, 95%CI: 9.50-12.00), 12.17(SD = 2.57, 95%CI: 10.33-14.00). After simulation training PGY 1 residents did as well as well as the upper level residents. Posttest mean test scores for PGY 1, 2, 3, 4 were 13.75(SD = 1.49, 95%CI: 12.75-14.63), 10.25(SD = 0.24, 95%CI: 4.25-14.00), 15.00(SD = 1.16, 95%CI: 14.00-16.00), 15.17(SD = 0.75, 95%CI: 14.67-15.67). CONCLUSION: Our simulation based training program not only produced short term gains, but participants were able to retain the skills learned and demonstrate their knowledge months later.
文摘Background: While causing a financial and economic loss in many countries in a few months, COVID 19 was of great impact on public health. The Iraqi government took several measures since the first Iraqi case was discovered in February 2020. One of the fundamental measures to control this pandemic is social isolation, which depends greatly on people’s awareness to decrease the incidence of COVID-19. Objectives: To study the COVID-19-effect on dentists’ social life and their future plan, and to find the relation between that effect and some dentists’ demographic variables. Methods: A cross-sectional study was conducted from 2nd January to 7th May 2021, by an electronic version of the questionnaire through Google form. With facilitating orders delivered to all the specialist dental centers for adults of Al-Resafa health directorate;any dentists working in specialist dental centers for adults of Al-Resafa health directorate, and accept to participate in this study. Results: A total of 10 specialist dental centers for adults of the Al-Resafa health directorate represent 566/628 dentists enrolled in this study with a response rate of 88.99%. Most of them aged less than 30 years old (62.2%), female (60.6%), married status (50.4%), had 1 - 3 children (71.91%), Rotator (51.1%), with less than five years of experience (61.3%). Conclusion: COVID-19 affected so many aspects of health workers’ lives including dentists. About two-thirds of dentists had negative feelings, of which almost all had anxiety. Younger ages, females, married and having children are factors that contribute to the affection of dental social lives more than other categories.
文摘Implement the innovation of the ＂apprenticeship＂ training method in the teachers, explore the effective ways of cultivating the young teachers and the transferred teachers, determine the guidance teachers and the training objects through the combination of rec- ommendation and self-recommendation, sign the mentoring agreement, establish the scientific and effective assessment and incentive mechanisms, to promote the healthy growth of the groups of teachers and the orderly cohesion the replacement of the old and new teachers.
文摘We performed a retrospective analysis of 9 patients with acute myeloid leukemia (AML) treated with gemtuzumab ozogamicin (GO) plus cytarabine as a salvage regimen (GO reinduction) for patients who did not achieve complete remission (CR) after the first cycle of induction chemotherapy or at first relapse. Cases of AML secondary to myelodysplastic syndrome or myeloproliferative disorder were included. CR was achieved in 6 of 9 patients, and 2 of 6 responders became long-term survivors. No non-responders survived longer than 6 months. Toxicity was mild, and the median duration of myelosuppression was less than 30 days. Stomatitis, nausea and sepsis occurred as non-hematological adverse events. Although our sample size was too small to permit definitive conclusions, GO reinduction should be considered for patients who relapse or do not achieve CR after the first cycle of induction chemotherapy. Some AML subtypes may respond more robustly than others, and further investigation is warranted.
文摘"No danger is safe, no lack is complete." Safety in production is an insurmountable red bottom line for every enterprise. The guarantee of safety in production lies in both material factors and human factors. The most important and basic part of this factor is safety education. Safety education and training are in place, safety education knowledge is effectively instilled, and the content and carrier of safety education and training are practical, which is both the foundation and the focus. Therefore, it is necessary to establish a safety education and training mechanism in order to maintain the orderly development of the production and operation of enterprises. Only effective safety education, training and training methods break through the traditional mode, can employees carry out safety production based on their posts, and protecting themselves is one of the important factors of safety.
文摘Safe production is the focus of various management works in power generation enterprises, the foundation for further development of power enterprises and the cornerstone for power enterprises to obtain economic benefits. The safety of electricity production is directly related to the stability of social development and people's practical interests. In recent years, the situation of production safety in power enterprises has become increasingly severe. In order to improve the management level of production safety, power enterprises must strengthen the management of production safety and fundamentally improve the management level of production safety. This paper studies and analyzes the work of safety education and training for reference.
文摘Introduction: Postpartum mental disorders are psychopathological states that affect women after childbirth. These disorders often negatively impact a child’s mental health and the mother-child bond. The objective of this work was to determine the frequency of mental disorders during the postpartum period at the University Community Health Center of Konobougou in Mali. Methods: This descriptive cross-sectional study took place from March 1 to July 31, 2022, for four months. Results: The study involved 201 immediate postpartum women at the Konobougou Community and University Health Center. The 20-35 age group accounted for 70.00% of the population;the average age was 24 years ± 5.95 years, with a range of 15 to 45 years. Married women made up 96.00% of the sample. The overall frequency of mental disorders was 15.92%. The mental disorders recorded were postpartum depression (5.47%), anxiety disorders (3.98%), postpartum blues (5.47%), and posttraumatic stress disorder (0.50%). Puerperal psychosis was found in 0.50% of the participants. Conclusion: This study revealed a high prevalence of mental disorders among postpartum women in Konobougou, Mali. During postnatal consultations, health workers should prioritize screening for mental health disorders.
文摘BACKGROUND Simulated microgravity environment can lead to gastrointestinal motility disturbance.The pathogenesis of gastrointestinal motility disorders is closely related to the stem cell factor(SCF)/c-kit signaling pathway associated with intestinal flora and Cajal stromal cells.Moreover,intestinal flora can also affect the regulation of SCF/c-kit signaling pathway,thus affecting the expression of Cajal stromal cells.Cajal cells are the pacemakers of gastrointestinal motility.AIM To investigate the effects of Bifidobacterium lactis(B.lactis)BLa80 on the intestinal flora of rats in simulated microgravity and on the gastrointestinal motility-related SCF/c-kit pathway.METHODS The internationally recognized tail suspension animal model was used to simulate the microgravity environment,and 30 rats were randomly divided into control group,tail suspension group and drug administration tail suspension group with 10 rats in each group for a total of 28 days.The tail group was given B.lactis BLa80 by intragastric administration,and the other two groups were given water intragastric administration,the concentration of intragastric administration was 0.1 g/mL,and each rat was 1 mL/day.Hematoxylin&eosin staining was used to observe the histopathological changes in each segment of the intestine of each group,and the expression levels of SCF,c-kit,extracellular signal-regulated kinase(ERK)and p-ERK in the gastric antrum of each group were detected by Western blotting and PCR.The fecal flora and mucosal flora of rats in each group were detected by 16S rRNA.RESULTS Simulated microgravity resulted in severe exfoliation of villi of duodenum,jejunum and ileum in rats,marked damage,increased space between villi,loose arrangement,shortened columnar epithelium of colon,less folds,narrower mucosal thickness,reduced goblet cell number and crypts,and significant improvement after probiotic intervention.Simulated microgravity reduced the expressions of SCF and c-kit,and increased the expressions of ERK and P-ERK in the gastric antrum of rats.However,after probiotic intervention,the expressions of SCF and ckit were increased,while the expressions of ERK and P-ERK were decreased,with statistical significance(P<0.05).In addition,simulated microgravity can reduce the operational taxonomic unit(OTU)of the overall intestinal flora of rats,B.lactis BLa80 can increase the OTU of rats,simulated microgravity can reduce the overall richness and diversity of stool flora of rats,increase the abundance of firmicutes in stool flora of rats,and reduce the abundance of Bacteroides in stool flora of rats,most of which are mainly beneficial bacteria.Simulated microgravity can increase the overall richness and diversity of mucosal flora,increase the abundance of Bacteroides and Desulphurides in the rat mucosal flora,and decrease the abundance of firmicutes,most of which are proteobacteria.After probiotics intervention,the overall Bacteroidetes trend in simulated microgravity rats was increased.CONCLUSION B.lactis BLa80 can ameliorate intestinal mucosal injury,regulate intestinal flora,inhibit ERK expression,and activate the SCF/c-kit signaling pathway,which may have a facilitating effect on gastrointestinal motility in simulated microgravity rats.
基金supported by the Scientific Research Program of Tianjin Education Committee(No.2022ZD030)。
文摘7075 aluminum alloy is often used as an important load-bearing structure in aircraft industry due to its superior mechanical properties.During the process of deep hole boring,the boring bar is prone to vibrate because of its limited machining space,bad environment and large elongation induced low stiffness.To reduce vibration and improve machined surface quality,a particle damping boring bar,filled with particles in its inside damping block,is designed based on the theory of vibration control.The theoretical damping coefficient is determined,then the boring bar structure is designed and trial-manufactured.Experimental studies through impact testing show that cemented carbide particles with a diameter of 5 mm and a filling rate of 70% achieve a damping ratio of 19.386%,providing excellent vibration reduction capabilities,which may reduce the possibility of boring vibration.Then,experiments are setup to investigate its vibration reduction performance during deep hole boring of 7075 aluminum alloy.To observe more obviously,severe working conditions are adopted and carried out to acquire the time domain vibration signal of the head of the boring bar and the surface morphologies and roughness values of the workpieces.By comparing different experimental results,it is found that the designed boring bar could reduce the maximum vibration amplitude by up to 81.01% and the surface roughness value by up to 47.09% compared with the ordinary boring bar in two sets of experiments,proving that the designed boring bar can effectively reduce vibration.This study can offer certain valuable insights for the machining of this material.
