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“Day Ward” and “Consultation Center of Intractable Pain Cases”——New services of Wuhan Tongji Cancer Center benefit patients
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第2期99-100,共2页
Recently, two new services - "Day Ward" and "Consultation Center of Intractable Pain Cases" - were launched in Wuhan Tongji Cancer Center, in order to simplify diagnosis and treatment process, and improve patients... Recently, two new services - "Day Ward" and "Consultation Center of Intractable Pain Cases" - were launched in Wuhan Tongji Cancer Center, in order to simplify diagnosis and treatment process, and improve patients' quality life, 展开更多
关键词 咨询中心 顽固性 服务 病房 疼痛 患者 癌症 武汉
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Tongji Cancer Center(Wuhan, China) held 2014 Multidisciplinary Symposium for The Consultation Center of Intractable Pain Cases
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2014年第7期341-341,共1页
The 2014 Multidisciplinary Symposium for The Consultation Center of Intractable Pain Cases was held on April 21th, 2014. Fourteen departments took part in the symposium.
关键词 顽固性 会诊 病例 疼痛 科研 武汉 中国 癌症
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Bring health,bring happiness and bring hope The series of activities of the 17th National Tumor Prophylaxis and Treatment Week in Tongji Cancer Center, Tongji Hospital, Wuhan,china
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第5期303-304,共2页
The 17th National Tumor Prophylaxis and Treatment Week, with the theme of "fight cancer scientifically and care life", kicked off in Wuhan, China. As one of the most important social works all over the year,... The 17th National Tumor Prophylaxis and Treatment Week, with the theme of "fight cancer scientifically and care life", kicked off in Wuhan, China. As one of the most important social works all over the year, the Week was broadened into a series of activities, lasting for one month, in Tongji Cancer Center, Tongji Hospital, Wu-han, China. 展开更多
关键词 预防癌症 肿瘤预防 武汉市 同济大学 中国 医院 治疗 健康
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Cancer, did you know?——Tongji Cancer Center held World Cancer Day 2013 in China
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第4期199-200,共2页
On February 2nd, World Cancer Day 2013 in China hosted by China Anti-Cancer Association (CACA), and jointly undertaken by Cancer Rehabilitation and Palliative Care Committee, China (CRPC), a branch of CACA,
关键词 癌症 中国 世界 委员会 协会
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Tongji cancer center held the 3rd session of PICC concern group
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第6期303-303,共1页
The 3rd Session of PICC Concern Group in Tongji Cancer Center was held in the classroom of Tongji Cancer Center on April 17th, 2013. PICC (peripherally inserted central catheter) is a new technique which is widely a... The 3rd Session of PICC Concern Group in Tongji Cancer Center was held in the classroom of Tongji Cancer Center on April 17th, 2013. PICC (peripherally inserted central catheter) is a new technique which is widely adopted in Chinese hospitals soon after it was invented. The technique need smooth cooperation of medical staff and patients. 展开更多
关键词 肿瘤 临床 治疗 化疗
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Tongji Cancer Center(Wuhan, China) held the 5th "Heart Warming" & National Tumor Prophylaxis and Treatment Week Party
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作者 Yi Cheng Zehuan Li 《The Chinese-German Journal of Clinical Oncology》 CAS 2014年第7期343-343,共1页
On April 12th, the 5th "Heart Warming" & National Tumor Prophylaxis and Treatment Week Party was held in the classroom of Tongji Cancer Center by Tongji Cancer Center and "Sunshine Medical Students" group of Tong... On April 12th, the 5th "Heart Warming" & National Tumor Prophylaxis and Treatment Week Party was held in the classroom of Tongji Cancer Center by Tongji Cancer Center and "Sunshine Medical Students" group of Tongji Young Volunteers Association. More than 100 patients and their care-givers enjoyed themselves in the party. 展开更多
关键词 武汉 中国 癌症
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Emerging mechanisms and implications of c GAS-STING signaling in cancer immunotherapy strategies 被引量:2
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作者 Jiawen Zhang Sihui Yu +2 位作者 Qiao Peng Ping Wang Lan Fang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第1期45-64,共20页
The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment.Within this landscape,the innate immune system,a critical sentinel prote... The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment.Within this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key player.The cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor microenvironment.Furthermore,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer immunotherapy.Current strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint inhibitors.These approaches have shown promise in preclinical and clinical settings,by enhancing patient survival rates.This review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and therapy.Moreover,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy strategies.Despite challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes. 展开更多
关键词 cGAS-STING pathway type I interferon cyclic dinucleotide STING agonist cancer immunotherapy
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Modeling human gastric cancers in immunocompetent mice
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作者 Weihong Zhang Shilong Wang +4 位作者 Hui Zhang Yan Meng Shi Jiao Liwei An Zhaocai Zhou 《Cancer Biology & Medicine》 SCIE CAS CSCD 2024年第7期553-570,共18页
Gastric cancer(GC)is a major cause of cancer-related mortality worldwide.GC is determined by multiple(epi)genetic and environmental factors;can occur at distinct anatomic positions of the stomach;and displays high het... Gastric cancer(GC)is a major cause of cancer-related mortality worldwide.GC is determined by multiple(epi)genetic and environmental factors;can occur at distinct anatomic positions of the stomach;and displays high heterogeneity,with different cellular origins and diverse histological and molecular features.This heterogeneity has hindered efforts to fully understand the pathology of GC and develop efficient therapeutics.In the past decade,great progress has been made in the study of GC,particularly in molecular subtyping,investigation of the immune microenvironment,and defining the evolutionary path and dynamics.Preclinical mouse models,particularly immunocompetent models that mimic the cellular and molecular features of human GC,in combination with organoid culture and clinical studies,have provided powerful tools for elucidating the molecular and cellular mechanisms underlying GC pathology and immune evasion,and the development of novel therapeutic strategies.Herein,we first briefly introduce current progress and challenges in GC study and subsequently summarize immunocompetent GC mouse models,emphasizing the potential application of genetically engineered mouse models in antitumor immunity and immunotherapy studies. 展开更多
关键词 Gastric cancer HETEROGENEITY mouse model GEMM IMMUNOCOMPETENT
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Mechanistic insights of neuronal death and neuroprotective therapeutic approaches in stroke 被引量:1
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作者 Chun Li Yuping Luo Siguang Li 《Neural Regeneration Research》 2026年第3期869-886,共18页
Stroke,particularly ischemic stroke,is the leading cause of long-term disability and mortality worldwide.It occurs due to the occlusion of the cerebral arteries,which significantly reduces the delivery of blood,oxygen... Stroke,particularly ischemic stroke,is the leading cause of long-term disability and mortality worldwide.It occurs due to the occlusion of the cerebral arteries,which significantly reduces the delivery of blood,oxygen,and essential nutrients to brain tissues.This deprivation triggers a cascade of cellular events that ultimately leads to neuronal death.Recent studies have clarified the multifactorial pathogenesis of ischemic stroke,highlighting the roles of energy failure,excitotoxicity,oxidative stress,neuroinflammation,and apoptosis.This review aimed to provide a comprehensive insight into the fundamental mechanisms driving neuronal death triggered by ischemia and to examine the progress of neuroprotective therapeutic approaches designed to mitigate neuronal loss and promote neurological recovery after a stroke.Additionally,we explored widely accepted findings regarding the potential pathways implicated in neuronal death during ischemic stroke,including the interplay of apoptosis,autophagy,pyroptosis,ferroptosis,and necrosis,which collectively influence neuronal fate.We also discussed advancements in neuroprotective therapeutics,encompassing a range of interventions from pharmacological modulation to stem cell-based therapies,aimed at reducing neuronal injury and enhancing functional recovery following ischemic stroke.Despite these advancements,challenges remain in translating mechanistic insights into effective clinical therapies.Although neuroprotective strategies have shown promise in preclinical models,their efficacy in human trials has been inconsistent,often due to the complex pathology of ischemic stroke and the timing of interventions.In conclusion,this review synthesizes mechanistic insights into the intricate interplay of molecular and cellular pathways driving neuronal death post-ischemia.It sheds light on cutting-edge advancements in potential neuroprotective therapeutics,underscores the promise of regenerative medicine,and offers a forward-looking perspective on potential clinical breakthroughs.The ongoing evolution of precision-targeted interventions is expected to significantly enhance preventative strategies and improve clinical outcomes. 展开更多
关键词 apoptosis cerebral infarction clinical trial inflammation ischemic stroke mitochondria neurons NEUROPROTECTION oxidative stress PATHOPHYSIOLOGY stem cells
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整合蛋白质组学与单细胞转录组学揭示SERPINB6棕榈酰化修饰促胃癌分子机制
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作者 杨婕 白俊平 +2 位作者 郭峰华 安利伟 周兆才 《中国细胞生物学学报》 2025年第8期1862-1876,共15页
蛋白质棕榈酰化修饰失调在肿瘤发生发展与治疗抵抗过程中扮演关键角色,但其在胃癌中的异常调控网络与修饰底物尚未完全明确。该研究首先通过分析TCGA数据库发现胃癌组织中ZDHHC家族棕榈酰化修饰酶表达与活性显著升高,且与患者不良预后... 蛋白质棕榈酰化修饰失调在肿瘤发生发展与治疗抵抗过程中扮演关键角色,但其在胃癌中的异常调控网络与修饰底物尚未完全明确。该研究首先通过分析TCGA数据库发现胃癌组织中ZDHHC家族棕榈酰化修饰酶表达与活性显著升高,且与患者不良预后及免疫治疗抵抗相关。进而利用4D无标记定量蛋白质组学技术结合代谢物标记的点击化学法绘制并比较了胃癌与癌旁棕榈酰化修饰蛋白图谱,共鉴定出了495个棕榈酰化修饰蛋白,KEGG和GO通路分析发现差异蛋白主要参与糖代谢重编程及氧化还原稳态调控。其中,SERPINB6和PPA1在肿瘤中显著上调而ALDH6A1和GLUL下调。最后,基于公共数据库的单细胞分析显示蛋白差异富集于肿瘤上皮亚群,关键差异蛋白SERPINB高表达通过激活脂代谢通路驱动脂肪酸代谢,并重塑细胞间通讯网络:增强细胞黏附相关信号促进物理屏障的形成,增强肿瘤细胞耐药及免疫抵抗,同时抑制T/NK细胞功能并促进免疫逃逸。该研究的结果揭示了棕榈酰化修饰蛋白SERPINB6可能通过代谢重编程与免疫微环境交互驱动胃癌进展的双重机制,为靶向该修饰网络的精准治疗策略提供了新的方向。 展开更多
关键词 胃癌 棕榈酰化修饰 蛋白质组 单细胞转录组学
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Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment:from molecular mechanisms to therapeutic strategies
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作者 Ziyou Lin Chang Chang +2 位作者 Shuyu Zhao Lan Fang Ping Wang 《Cancer Biology & Medicine》 2025年第7期726-746,共21页
The tumor immune microenvironment(TIME)represents a complex battlefield where metabolic competition and immune evasion mechanisms converge to drive cancer progression.Amino acids,with their multifaceted biological rol... The tumor immune microenvironment(TIME)represents a complex battlefield where metabolic competition and immune evasion mechanisms converge to drive cancer progression.Amino acids,with their multifaceted biological roles,have emerged as pivotal regulators of tumor cell proliferation and immune cell functionality.The sensing mechanisms by which amino acids within the tumor microenvironment influence cellular growth,survival,and immune function are systematically explored in this review;the latest advances in understanding amino acid metabolism in tumor biology are also reviewed.In addition,the multifaceted roles of key amino acids in shaping the TIME with particular emphasis on tumor immunity and malignant growth were investigated.Finally,emerging therapeutic strategies targeting amino acid metabolism to reprogram the TIME are discussed,highlighting promising approaches,such as CAR-T cell therapy and engineered bacterial interventions.Through this comprehensive analysis,critical insights into future research directions and potential clinical translation of amino acid-targeted interventions are provided. 展开更多
关键词 Tumor microenvironment(TME) amino acid sensing amino acid metabolism metabolic reprogramming immunotherapy
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Focus on quality of life,improve the patients' survival The 7th Conference of Chinese Cancer Rehabilitation and Palliative Care was held in Fuzhou,China 被引量:1
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第3期181-182,共2页
From Nov. 25th-27th, 2011, the 7th Conference of Chinese Cancer Rehabilitation and Palliative Care was held in Fuzhou, China. The conference focused on the patients' quality of life, and the methods to improve their ... From Nov. 25th-27th, 2011, the 7th Conference of Chinese Cancer Rehabilitation and Palliative Care was held in Fuzhou, China. The conference focused on the patients' quality of life, and the methods to improve their survival. The comprehensive therapy should be considered at the beginning of the treatment, and the treatment of rehabilitation and palliative care should be pursued throughout all the anti-cancer therapeutic process. 展开更多
关键词 康复治疗 生活质量 中国 福州 癌症 生存率 患者 综合治疗
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Adipose tissue macrophages:implications for obesity-associated cancer 被引量:2
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作者 Bei Li Si Sun +3 位作者 Juan-Juan Li Jing-Ping Yuan Sheng-Rong Sun Qi Wu 《Military Medical Research》 SCIE CAS CSCD 2023年第5期636-651,共16页
Obesity is one of the most serious global health problems,with an incidence that increases yearly and coincides with the development of cancer.Adipose tissue macrophages(ATMs)are particularly important in this context... Obesity is one of the most serious global health problems,with an incidence that increases yearly and coincides with the development of cancer.Adipose tissue macrophages(ATMs)are particularly important in this context and contribute to linking obesity-related inflammation and tumor progression.However,the functions of ATMs on the progression of obesity-associated cancer remain unclear.In this review,we describe the origins,phenotypes,and functions of ATMs.Subsequently,we summarize the potential mechanisms on the reprogramming of ATMs in the obesity-associated microenvironment,including the direct exchange of dysfunctional metabolites,inordinate cytokines and other signaling mediators,transfer of extracellular vesicle cargo,and variations in the gut microbiota and its metabolites.A better understanding of the properties and functions of ATMs under conditions of obesity will lead to the development of new therapeutic interventions for obesity-related cancer. 展开更多
关键词 Adipose tissue macrophages MACROPHAGE ADIPOSE OBESITY CANCER Therapy
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2013 National Cancer Specialist Palliative Care Training Class was held in Wuhan
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第7期353-354,共2页
2013 National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliative Care (EAPC), was held on May ... 2013 National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliative Care (EAPC), was held on May 18th–19th in Wuhan, China.More than 70 medical staff from 70 hospitals all over the country took part in the class.More than 10 specialists from home and abroad gave speeches on pain, digestive symptoms, respiratory symptoms, spiritual symptoms and end-of-life care.The training class was hosted by Professor Shiying Yu, chairmen of CPRC and chief of Tongji Cancer Center, and Professor Duanqi Liu, chief of Cancer Center, the General Hospital of Beijing Military Region (Fig.1). 展开更多
关键词 培训班 癌症 治疗 专家 武汉 美国 消化道症状 呼吸道症状
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The second session of 2013 National Cancer Specialist Palliative Care Training Class was held in Beijing
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第10期505-506,共2页
The second session of 2013 National Cancer Special- ist Palliative Care Training Class, jointly hosted by Can- cer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliative C... The second session of 2013 National Cancer Special- ist Palliative Care Training Class, jointly hosted by Can- cer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliative Care (EAPC), was held on July 20th-21th in Beijing. More than 60 medical staffs all over the country took part in the class. More than 10 specialists from home and abroad gave speeches on pain, digestive symptoms, respiratory symptoms, spiritual symptoms and end-of-life care. 展开更多
关键词 培训班 治疗 北京 专家 癌症 美国 呼吸道症状 医务人员
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Move Further on the Two-decade Journey through Rain or Shine The tenth National Cancer Rehabilitation and Palliative Care Conference was held in Shanghai
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2014年第8期395-396,共2页
The Tenth National Cancer Rehabilitation and Pal- liative Care Conference, with the theme of "Integrating Standardized Palliative Care throughout Anti-cancer Treatment", was successfully held on June 20th-22nd, 2014... The Tenth National Cancer Rehabilitation and Pal- liative Care Conference, with the theme of "Integrating Standardized Palliative Care throughout Anti-cancer Treatment", was successfully held on June 20th-22nd, 2014, in Shanghai. This conference was hosted by Can- cer Rehabilitation and Palliative Care Committee, China (CRPC), jointly undertaken by Shanghai Anti-Cancer As- sociation and Shanghai Changzheng Hospital, and joint- ly supported by Chinese Society of Clinical Oncology (CSCO), Shanghai Cancer Rehabilitation and Palliative Care Committee, Journey of"Chinese Clinical Oncology" and Cancer Committee of Shanghai Medical Association. More than 1,500 medical staff attended the conference. The opening ceremony was held on June 21st. It was hosted by Professor Li Zhang, Director of Sun Yat-Sen University Cancer Center. 展开更多
关键词 上海 治疗 康复 癌症 通过量 风雨 肿瘤防治中心 委员会
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No hot,no watery,no sweet,give correct food to patients receiving chemotherapy-CSCO-Lilly medical experts' auditorium gave a speech on lung cancer in Wuhan
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第4期245-245,共1页
The first speech of CSCO-Lilly medical experts' auditorium in the year of 2011 was given on February 15th in Wuhan. Professor Shiying Yu, the chief of Tongji Cancer Center, and chairman of CRPC,
关键词 武汉 专家 医学 甜味 食物 化疗 患者 肺癌
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The 2011 Symposium of Cancer Rehabilitation and Palliative Care Committee,Hubei,China was held in Wuhan,China Professor Yuan Chen was elected as the new chairmen of Cancer Rehabilitation and Palliative Care Committee, Hubei, China
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2012年第3期183-183,共1页
On Dec. 9th, 2011, the 2011 Symposium of Cancer Re- habilitation and Palliative Care Committee, Hubei was held in Wuhan, China. The symposium was hosted by Cancer Rehabilitation and Palliative Care Committee, Hubei, a... On Dec. 9th, 2011, the 2011 Symposium of Cancer Re- habilitation and Palliative Care Committee, Hubei was held in Wuhan, China. The symposium was hosted by Cancer Rehabilitation and Palliative Care Committee, Hubei, and jointly undertaken by Tongji Hospital, China. More than 100 cancer experts, clinicians and nurses participated in the conference. Professor Yuan Chen, from Tongji Cancer Center, Tongji Hospital, China, was elected as the new chairmen of Cancer Rehabilitation and Palliative Care Committee, Hubei, China. 展开更多
关键词 委员会 湖北省 癌症 中国 治疗 康复 武汉 学术研讨会
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Love life,scientific anti-cancer,better life
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2010年第6期368-368,共1页
The Chinese Anti-cancer Association launched the 16th National Tumor Prophylaxis and Treatment Week in April, 2010. In order to highlight the week's spirit of "Love life, scientific anti-cancer, better life", the T... The Chinese Anti-cancer Association launched the 16th National Tumor Prophylaxis and Treatment Week in April, 2010. In order to highlight the week's spirit of "Love life, scientific anti-cancer, better life", the Tongji Cancer Center and Thoracic Surgery Department held lectures and advisory services in the outpatient lobby of Cancer Center on April 20th, 2010. The content of lectures involves the prophylaxis, diagnosis and treatment of lung cancer, 展开更多
关键词 生活 抗癌 科学 咨询服务 同济大学 治疗 预防 癌症
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The 2014 “SMILE” National Cancer SpecialistPalliative Care Training Class was held successfully
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作者 Yi Cheng 《The Chinese-German Journal of Clinical Oncology》 CAS 2014年第7期342-342,共1页
Four sessions of the 2014 "SMILE" National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliat... Four sessions of the 2014 "SMILE" National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliative Care (EAPC), supported by Xian-Janssen Pharmaceutical Ltd., was successfully held, including March 8th in Suzhou, March 22nd in Guangzhou, April 12th in Chengdu and April 26th in Wuhan. More than 200 medical staff all over the country took part in the class. 展开更多
关键词 培训班 癌症 专家 医务人员 委员会 治疗
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