Recently, two new services - ＂Day Ward＂ and ＂Consultation Center of Intractable Pain Cases＂ - were launched in Wuhan Tongji Cancer Center, in order to simplify diagnosis and treatment process, and improve patients...Recently, two new services - ＂Day Ward＂ and ＂Consultation Center of Intractable Pain Cases＂ - were launched in Wuhan Tongji Cancer Center, in order to simplify diagnosis and treatment process, and improve patients＇ quality life,展开更多
The 2014 Multidisciplinary Symposium for The Consultation Center of Intractable Pain Cases was held on April 21th, 2014. Fourteen departments took part in the symposium.
The 17th National Tumor Prophylaxis and Treatment Week, with the theme of "fight cancer scientifically and care life", kicked off in Wuhan, China. As one of the most important social works all over the year,...The 17th National Tumor Prophylaxis and Treatment Week, with the theme of "fight cancer scientifically and care life", kicked off in Wuhan, China. As one of the most important social works all over the year, the Week was broadened into a series of activities, lasting for one month, in Tongji Cancer Center, Tongji Hospital, Wu-han, China.展开更多
On February 2nd, World Cancer Day 2013 in China hosted by China Anti-Cancer Association （CACA）, and jointly undertaken by Cancer Rehabilitation and Palliative Care Committee, China （CRPC）, a branch of CACA,
The 3rd Session of PICC Concern Group in Tongji Cancer Center was held in the classroom of Tongji Cancer Center on April 17th, 2013. PICC （peripherally inserted central catheter） is a new technique which is widely a...The 3rd Session of PICC Concern Group in Tongji Cancer Center was held in the classroom of Tongji Cancer Center on April 17th, 2013. PICC （peripherally inserted central catheter） is a new technique which is widely adopted in Chinese hospitals soon after it was invented. The technique need smooth cooperation of medical staff and patients.展开更多
On April 12th, the 5th ＂Heart Warming＂ ＆ National Tumor Prophylaxis and Treatment Week Party was held in the classroom of Tongji Cancer Center by Tongji Cancer Center and ＂Sunshine Medical Students＂ group of Tong...On April 12th, the 5th ＂Heart Warming＂ ＆ National Tumor Prophylaxis and Treatment Week Party was held in the classroom of Tongji Cancer Center by Tongji Cancer Center and ＂Sunshine Medical Students＂ group of Tongji Young Volunteers Association. More than 100 patients and their care-givers enjoyed themselves in the party.展开更多
Stroke,particularly ischemic stroke,is the leading cause of long-term disability and mortality worldwide.It occurs due to the occlusion of the cerebral arteries,which significantly reduces the delivery of blood,oxygen...Stroke,particularly ischemic stroke,is the leading cause of long-term disability and mortality worldwide.It occurs due to the occlusion of the cerebral arteries,which significantly reduces the delivery of blood,oxygen,and essential nutrients to brain tissues.This deprivation triggers a cascade of cellular events that ultimately leads to neuronal death.Recent studies have clarified the multifactorial pathogenesis of ischemic stroke,highlighting the roles of energy failure,excitotoxicity,oxidative stress,neuroinflammation,and apoptosis.This review aimed to provide a comprehensive insight into the fundamental mechanisms driving neuronal death triggered by ischemia and to examine the progress of neuroprotective therapeutic approaches designed to mitigate neuronal loss and promote neurological recovery after a stroke.Additionally,we explored widely accepted findings regarding the potential pathways implicated in neuronal death during ischemic stroke,including the interplay of apoptosis,autophagy,pyroptosis,ferroptosis,and necrosis,which collectively influence neuronal fate.We also discussed advancements in neuroprotective therapeutics,encompassing a range of interventions from pharmacological modulation to stem cell-based therapies,aimed at reducing neuronal injury and enhancing functional recovery following ischemic stroke.Despite these advancements,challenges remain in translating mechanistic insights into effective clinical therapies.Although neuroprotective strategies have shown promise in preclinical models,their efficacy in human trials has been inconsistent,often due to the complex pathology of ischemic stroke and the timing of interventions.In conclusion,this review synthesizes mechanistic insights into the intricate interplay of molecular and cellular pathways driving neuronal death post-ischemia.It sheds light on cutting-edge advancements in potential neuroprotective therapeutics,underscores the promise of regenerative medicine,and offers a forward-looking perspective on potential clinical breakthroughs.The ongoing evolution of precision-targeted interventions is expected to significantly enhance preventative strategies and improve clinical outcomes.展开更多
From Nov. 25th-27th, 2011, the 7th Conference of Chinese Cancer Rehabilitation and Palliative Care was held in Fuzhou, China. The conference focused on the patients＇ quality of life, and the methods to improve their ...From Nov. 25th-27th, 2011, the 7th Conference of Chinese Cancer Rehabilitation and Palliative Care was held in Fuzhou, China. The conference focused on the patients＇ quality of life, and the methods to improve their survival. The comprehensive therapy should be considered at the beginning of the treatment, and the treatment of rehabilitation and palliative care should be pursued throughout all the anti-cancer therapeutic process.展开更多
The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment.Within this landscape,the innate immune system,a critical sentinel prote...The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment.Within this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key player.The cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor microenvironment.Furthermore,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer immunotherapy.Current strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint inhibitors.These approaches have shown promise in preclinical and clinical settings,by enhancing patient survival rates.This review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and therapy.Moreover,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy strategies.Despite challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.展开更多
Obesity is one of the most serious global health problems,with an incidence that increases yearly and coincides with the development of cancer.Adipose tissue macrophages(ATMs)are particularly important in this context...Obesity is one of the most serious global health problems,with an incidence that increases yearly and coincides with the development of cancer.Adipose tissue macrophages(ATMs)are particularly important in this context and contribute to linking obesity-related inflammation and tumor progression.However,the functions of ATMs on the progression of obesity-associated cancer remain unclear.In this review,we describe the origins,phenotypes,and functions of ATMs.Subsequently,we summarize the potential mechanisms on the reprogramming of ATMs in the obesity-associated microenvironment,including the direct exchange of dysfunctional metabolites,inordinate cytokines and other signaling mediators,transfer of extracellular vesicle cargo,and variations in the gut microbiota and its metabolites.A better understanding of the properties and functions of ATMs under conditions of obesity will lead to the development of new therapeutic interventions for obesity-related cancer.展开更多
2013 National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliative Care (EAPC), was held on May ...2013 National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliative Care (EAPC), was held on May 18th–19th in Wuhan, China.More than 70 medical staff from 70 hospitals all over the country took part in the class.More than 10 specialists from home and abroad gave speeches on pain, digestive symptoms, respiratory symptoms, spiritual symptoms and end-of-life care.The training class was hosted by Professor Shiying Yu, chairmen of CPRC and chief of Tongji Cancer Center, and Professor Duanqi Liu, chief of Cancer Center, the General Hospital of Beijing Military Region (Fig.1).展开更多
The second session of 2013 National Cancer Special- ist Palliative Care Training Class, jointly hosted by Can- cer Rehabilitation and Palliative Care Committee, China （CRPC） and European Association for Palliative C...The second session of 2013 National Cancer Special- ist Palliative Care Training Class, jointly hosted by Can- cer Rehabilitation and Palliative Care Committee, China （CRPC） and European Association for Palliative Care （EAPC）, was held on July 20th-21th in Beijing. More than 60 medical staffs all over the country took part in the class. More than 10 specialists from home and abroad gave speeches on pain, digestive symptoms, respiratory symptoms, spiritual symptoms and end-of-life care.展开更多
The Tenth National Cancer Rehabilitation and Pal- liative Care Conference, with the theme of ＂Integrating Standardized Palliative Care throughout Anti-cancer Treatment＂, was successfully held on June 20th-22nd, 2014...The Tenth National Cancer Rehabilitation and Pal- liative Care Conference, with the theme of ＂Integrating Standardized Palliative Care throughout Anti-cancer Treatment＂, was successfully held on June 20th-22nd, 2014, in Shanghai. This conference was hosted by Can- cer Rehabilitation and Palliative Care Committee, China （CRPC）, jointly undertaken by Shanghai Anti-Cancer As- sociation and Shanghai Changzheng Hospital, and joint- ly supported by Chinese Society of Clinical Oncology （CSCO）, Shanghai Cancer Rehabilitation and Palliative Care Committee, Journey of＂Chinese Clinical Oncology＂ and Cancer Committee of Shanghai Medical Association. More than 1,500 medical staff attended the conference. The opening ceremony was held on June 21st. It was hosted by Professor Li Zhang, Director of Sun Yat-Sen University Cancer Center.展开更多
The first speech of CSCO-Lilly medical experts＇ auditorium in the year of 2011 was given on February 15th in Wuhan. Professor Shiying Yu, the chief of Tongji Cancer Center, and chairman of CRPC,
On Dec. 9th, 2011, the 2011 Symposium of Cancer Re- habilitation and Palliative Care Committee, Hubei was held in Wuhan, China. The symposium was hosted by Cancer Rehabilitation and Palliative Care Committee, Hubei, a...On Dec. 9th, 2011, the 2011 Symposium of Cancer Re- habilitation and Palliative Care Committee, Hubei was held in Wuhan, China. The symposium was hosted by Cancer Rehabilitation and Palliative Care Committee, Hubei, and jointly undertaken by Tongji Hospital, China. More than 100 cancer experts, clinicians and nurses participated in the conference. Professor Yuan Chen, from Tongji Cancer Center, Tongji Hospital, China, was elected as the new chairmen of Cancer Rehabilitation and Palliative Care Committee, Hubei, China.展开更多
The Chinese Anti-cancer Association launched the 16th National Tumor Prophylaxis and Treatment Week in April, 2010. In order to highlight the week＇s spirit of ＂Love life, scientific anti-cancer, better life＂, the T...The Chinese Anti-cancer Association launched the 16th National Tumor Prophylaxis and Treatment Week in April, 2010. In order to highlight the week＇s spirit of ＂Love life, scientific anti-cancer, better life＂, the Tongji Cancer Center and Thoracic Surgery Department held lectures and advisory services in the outpatient lobby of Cancer Center on April 20th, 2010. The content of lectures involves the prophylaxis, diagnosis and treatment of lung cancer,展开更多
Four sessions of the 2014 ＂SMILE＂ National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China （CRPC） and European Association for Palliat...Four sessions of the 2014 ＂SMILE＂ National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China （CRPC） and European Association for Palliative Care （EAPC）, supported by Xian-Janssen Pharmaceutical Ltd., was successfully held, including March 8th in Suzhou, March 22nd in Guangzhou, April 12th in Chengdu and April 26th in Wuhan. More than 200 medical staff all over the country took part in the class.展开更多
Objective： The aim of our study was to investigate if common toxicities are correlated to objective response rate （ORR） in metastatic colorectal cancer （mCRC） patients treated by irinotecan based regimens. Method...Objective： The aim of our study was to investigate if common toxicities are correlated to objective response rate （ORR） in metastatic colorectal cancer （mCRC） patients treated by irinotecan based regimens. Methods： Univadate and multivariate logistic regression analyses were performed to evaluate correlations between common toxicities and binary ORR in 106 mCRC patients from a prospective cohort treated with irinotecan based regimens. Results： The most frequent severe toxicities （Grade 3/4） were as follows： neutropenia （27.4%）, diarrhea （16.9%）, leucopenia （12.6%）, vomiting （3.2%） and thrombocytopenia （2.1%）. Thrombocytosis was observed in 25 （26.3%） patients. ORR was 25.3%. Thrombocytopenia （P = 0.014）, line of chemotherapy （P = 0.028） and thrembocytosis （P = 0.033） were correlated with ORR in univariate analysis. In multivariate analysis, thrombocytopenia （odds ratio [OR] = 8.600, 95% confidence interval [CI] = 1.705-43.385, P = 0.009） and first line chemotherapy （OR = 5.155, 95% CI = 1.153-23.256, P = 0.032） positively related to ORR. Conclusion： Threm- bocytopenia may be an indicator of ORR in mCRC patients treated by irinotecan plus 5-fluorouracil/capecitabine. Evidence is not strong enough to prove that irinotecan based regimens-induced diarrhea, leucopenia, neutropenia or vomiting is associ- ated with ORR.展开更多
Objective: The purpose of the study was to survey current G-CSF use in cancer patients, investigate whether the use of granulocyte colony-stimulating factor(G-CSF) is standardized. Methods: From July 2012 to October 2...Objective: The purpose of the study was to survey current G-CSF use in cancer patients, investigate whether the use of granulocyte colony-stimulating factor(G-CSF) is standardized. Methods: From July 2012 to October 2012, patients in a third-grade class-A hospital were investigated by self-designed questionnaires, according to ASCO's recommendations for white blood cell growth factors in 2006 and NCCN myeloid growth factors guideline in 2012. Results: Two hundred and twenty-two patients treated with 724 courses of chemotherapy were included. In prophylactic use, 259(35.8%) cases used G-CSF that the guideline doesn't recommend, which belonged to excessive use, the dose were 274 700 μg, accounting for 59.7% of the totle prophylactic use; 105(14.5%) didn't use while the guideline recommend, belonging to lack of use. 89.0% of the prophylactic use were 24–72 h after chemotherapy, only a few(5.4%) on the day of chemotherapy. In therapeutic use, only 3.1% were standardized, with the dose of 23 000 μg, accounting for 7.4% of the total. So 92.6% were excessive. 14.2% of the therapeutic use were 24–72 h after chemotherapy, 21.2% on the day of chemotherapy. Conclusion: More than 50% use of G-CSF weren't standardized, especially the excessive use.展开更多
Objective: The aim of the study was to investigate advanced medical students' knowledge towards cancer pain management, and understand the effect of specialisms and duration of oncology rotation on the advanced me...Objective: The aim of the study was to investigate advanced medical students' knowledge towards cancer pain management, and understand the effect of specialisms and duration of oncology rotation on the advanced medical students' cognitive level towards cancer pain management. Methods: Randomly selected the respondents from a medical school in Wuhan, China. The educational background of the respondents should belong to one of these conditions: (1) clinical master degree candidate; (2) clinical doctor degree candidate; (3) the sixth or seventh year of clinical medicine for seven years. The respondents should also spend more than one year on internship. The self-developed questionnaire papers were distributed to respondents in the unit of dorms selected randomly and recovered them immediately after they're finished. The categori- cal data were expressed at the form of frequency (rate or constituent ratio). Chi-square test was required only as needed. Results: The survey was anonymous. We distributed 300 papers, recovered 300 papers and weeded out 8 invalid papers. Finally there were 292 valid papers, and the valid recovery rate was 97.3%. The 96.7% of oncological medical students and 47.6% non-oncological medical students relied on patients' description for cancer pain assessments; 90.0% of oncological medical students and 53.0% of non-oncological medical students prescribed strong opioid drugs firstly for patients suffering severe cancer pain; only 24.1% of non-oncological medical students recognized that pethidine was not safe and effective to treat cancer pain, which was much lower than oncological medical students (90.0%); 73.3% of oncological medical students and 28.9% of non-oncological medical students had the correct impression of drug addiction; 85.5% of non-oncological medi- cal students worried about the drug addiction, while 60.0% of oncological medical students worried about the strict control over opioid. In respect of the details of cancer pain management, only 66.7% of oncological medical students recognized that there was no upper limit of opioid prescribed clinically, and 16.3% of oncological medical students recognized that there was no psychological dependence if patients took opioid orally. The 69.8% of the students from no-less-than-two-week group relied on patients' description for cancer pain assessments, 76.7% prescribed strong opioid drugs firstly for patients suffer- ing severe cancer pain, 69.8% recognized that pethidine was not safe and effective to treat cancer pain, and 55.8% had the correct impression of drug addiction. All of the data were higher than that in no-rotation group and that in less-than-two-week group. The 51.2% of the students from no-less-than-two-week worried about drug addiction, which was the lowest of all. Conclusion: The cognitive level of advanced medical students towards cancer pain management is so low that it could not satisfy the clinical requirement, especially for the non-oncological medical students and the students spending little time on oncology rotation. Though the oncological medical students know something about cancer pain treatment, they know little about the details.展开更多
文摘Recently, two new services - ＂Day Ward＂ and ＂Consultation Center of Intractable Pain Cases＂ - were launched in Wuhan Tongji Cancer Center, in order to simplify diagnosis and treatment process, and improve patients＇ quality life,
文摘The 2014 Multidisciplinary Symposium for The Consultation Center of Intractable Pain Cases was held on April 21th, 2014. Fourteen departments took part in the symposium.
文摘The 17th National Tumor Prophylaxis and Treatment Week, with the theme of "fight cancer scientifically and care life", kicked off in Wuhan, China. As one of the most important social works all over the year, the Week was broadened into a series of activities, lasting for one month, in Tongji Cancer Center, Tongji Hospital, Wu-han, China.
文摘On February 2nd, World Cancer Day 2013 in China hosted by China Anti-Cancer Association （CACA）, and jointly undertaken by Cancer Rehabilitation and Palliative Care Committee, China （CRPC）, a branch of CACA,
文摘The 3rd Session of PICC Concern Group in Tongji Cancer Center was held in the classroom of Tongji Cancer Center on April 17th, 2013. PICC （peripherally inserted central catheter） is a new technique which is widely adopted in Chinese hospitals soon after it was invented. The technique need smooth cooperation of medical staff and patients.
文摘On April 12th, the 5th ＂Heart Warming＂ ＆ National Tumor Prophylaxis and Treatment Week Party was held in the classroom of Tongji Cancer Center by Tongji Cancer Center and ＂Sunshine Medical Students＂ group of Tongji Young Volunteers Association. More than 100 patients and their care-givers enjoyed themselves in the party.
基金supported by the National Natural Science Foundation of China,Nos.82171387 and 31830111(both to SL).
文摘Stroke,particularly ischemic stroke,is the leading cause of long-term disability and mortality worldwide.It occurs due to the occlusion of the cerebral arteries,which significantly reduces the delivery of blood,oxygen,and essential nutrients to brain tissues.This deprivation triggers a cascade of cellular events that ultimately leads to neuronal death.Recent studies have clarified the multifactorial pathogenesis of ischemic stroke,highlighting the roles of energy failure,excitotoxicity,oxidative stress,neuroinflammation,and apoptosis.This review aimed to provide a comprehensive insight into the fundamental mechanisms driving neuronal death triggered by ischemia and to examine the progress of neuroprotective therapeutic approaches designed to mitigate neuronal loss and promote neurological recovery after a stroke.Additionally,we explored widely accepted findings regarding the potential pathways implicated in neuronal death during ischemic stroke,including the interplay of apoptosis,autophagy,pyroptosis,ferroptosis,and necrosis,which collectively influence neuronal fate.We also discussed advancements in neuroprotective therapeutics,encompassing a range of interventions from pharmacological modulation to stem cell-based therapies,aimed at reducing neuronal injury and enhancing functional recovery following ischemic stroke.Despite these advancements,challenges remain in translating mechanistic insights into effective clinical therapies.Although neuroprotective strategies have shown promise in preclinical models,their efficacy in human trials has been inconsistent,often due to the complex pathology of ischemic stroke and the timing of interventions.In conclusion,this review synthesizes mechanistic insights into the intricate interplay of molecular and cellular pathways driving neuronal death post-ischemia.It sheds light on cutting-edge advancements in potential neuroprotective therapeutics,underscores the promise of regenerative medicine,and offers a forward-looking perspective on potential clinical breakthroughs.The ongoing evolution of precision-targeted interventions is expected to significantly enhance preventative strategies and improve clinical outcomes.
文摘From Nov. 25th-27th, 2011, the 7th Conference of Chinese Cancer Rehabilitation and Palliative Care was held in Fuzhou, China. The conference focused on the patients＇ quality of life, and the methods to improve their survival. The comprehensive therapy should be considered at the beginning of the treatment, and the treatment of rehabilitation and palliative care should be pursued throughout all the anti-cancer therapeutic process.
基金the National Key Research and Development Program of China(Grant Nos.2022YFC3401500 and 2020YFA0803201 to P.W.,and 2021YFA1302200 to L.F.)the National Natural Science Foundation of China(Grant Nos.31830053,31920103007,and 82341028 to P.W.+1 种基金82122056,82073153,and 31871398 to L.F.and 31900568 to P.W.)the Natural Science Foundation of Shanghai(Grant No.22ZR1450700 to Z.J.W.)。
文摘The intricate interplay between the human immune system and cancer development underscores the central role of immunotherapy in cancer treatment.Within this landscape,the innate immune system,a critical sentinel protecting against tumor incursion,is a key player.The cyclic GMP-AMP synthase(c GAS)and stimulator of interferon genes(STING)pathway has been found to be a linchpin of innate immunity:activation of this signaling pathway orchestrates the production of type I interferon(IFN-α/β),thus fostering the maturation,differentiation,and mobilization of immune effectors in the tumor microenvironment.Furthermore,STING activation facilitates the release and presentation of tumor antigens,and therefore is an attractive target for cancer immunotherapy.Current strategies to activate the STING pathway,including use of pharmacological agonists,have made substantial advancements,particularly when combined with immune checkpoint inhibitors.These approaches have shown promise in preclinical and clinical settings,by enhancing patient survival rates.This review describes the evolving understanding of the c GAS-STING pathway's involvement in tumor biology and therapy.Moreover,this review explores classical and non-classical STING agonists,providing insights into their mechanisms of action and potential for optimizing immunotherapy strategies.Despite challenges and complexities,the c GAS-STING pathway,a promising avenue for enhancing cancer treatment efficacy,has the potential to revolutionize patient outcomes.
基金supported by the Fundamental Research Funds for the Central Universities(2042021kf0102,2042021kf0083)supported by two National Natural Science Foundation of China(NSFC)Grants(81903166,82203629)+1 种基金a Natural Science Foundation of Hubei(2018CKB916)sponsored by Shanghai Pujiang Program(22PJD054).
文摘Obesity is one of the most serious global health problems,with an incidence that increases yearly and coincides with the development of cancer.Adipose tissue macrophages(ATMs)are particularly important in this context and contribute to linking obesity-related inflammation and tumor progression.However,the functions of ATMs on the progression of obesity-associated cancer remain unclear.In this review,we describe the origins,phenotypes,and functions of ATMs.Subsequently,we summarize the potential mechanisms on the reprogramming of ATMs in the obesity-associated microenvironment,including the direct exchange of dysfunctional metabolites,inordinate cytokines and other signaling mediators,transfer of extracellular vesicle cargo,and variations in the gut microbiota and its metabolites.A better understanding of the properties and functions of ATMs under conditions of obesity will lead to the development of new therapeutic interventions for obesity-related cancer.
文摘2013 National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China (CRPC) and European Association for Palliative Care (EAPC), was held on May 18th–19th in Wuhan, China.More than 70 medical staff from 70 hospitals all over the country took part in the class.More than 10 specialists from home and abroad gave speeches on pain, digestive symptoms, respiratory symptoms, spiritual symptoms and end-of-life care.The training class was hosted by Professor Shiying Yu, chairmen of CPRC and chief of Tongji Cancer Center, and Professor Duanqi Liu, chief of Cancer Center, the General Hospital of Beijing Military Region (Fig.1).
文摘The second session of 2013 National Cancer Special- ist Palliative Care Training Class, jointly hosted by Can- cer Rehabilitation and Palliative Care Committee, China （CRPC） and European Association for Palliative Care （EAPC）, was held on July 20th-21th in Beijing. More than 60 medical staffs all over the country took part in the class. More than 10 specialists from home and abroad gave speeches on pain, digestive symptoms, respiratory symptoms, spiritual symptoms and end-of-life care.
文摘The Tenth National Cancer Rehabilitation and Pal- liative Care Conference, with the theme of ＂Integrating Standardized Palliative Care throughout Anti-cancer Treatment＂, was successfully held on June 20th-22nd, 2014, in Shanghai. This conference was hosted by Can- cer Rehabilitation and Palliative Care Committee, China （CRPC）, jointly undertaken by Shanghai Anti-Cancer As- sociation and Shanghai Changzheng Hospital, and joint- ly supported by Chinese Society of Clinical Oncology （CSCO）, Shanghai Cancer Rehabilitation and Palliative Care Committee, Journey of＂Chinese Clinical Oncology＂ and Cancer Committee of Shanghai Medical Association. More than 1,500 medical staff attended the conference. The opening ceremony was held on June 21st. It was hosted by Professor Li Zhang, Director of Sun Yat-Sen University Cancer Center.
文摘The first speech of CSCO-Lilly medical experts＇ auditorium in the year of 2011 was given on February 15th in Wuhan. Professor Shiying Yu, the chief of Tongji Cancer Center, and chairman of CRPC,
文摘On Dec. 9th, 2011, the 2011 Symposium of Cancer Re- habilitation and Palliative Care Committee, Hubei was held in Wuhan, China. The symposium was hosted by Cancer Rehabilitation and Palliative Care Committee, Hubei, and jointly undertaken by Tongji Hospital, China. More than 100 cancer experts, clinicians and nurses participated in the conference. Professor Yuan Chen, from Tongji Cancer Center, Tongji Hospital, China, was elected as the new chairmen of Cancer Rehabilitation and Palliative Care Committee, Hubei, China.
文摘The Chinese Anti-cancer Association launched the 16th National Tumor Prophylaxis and Treatment Week in April, 2010. In order to highlight the week＇s spirit of ＂Love life, scientific anti-cancer, better life＂, the Tongji Cancer Center and Thoracic Surgery Department held lectures and advisory services in the outpatient lobby of Cancer Center on April 20th, 2010. The content of lectures involves the prophylaxis, diagnosis and treatment of lung cancer,
文摘Four sessions of the 2014 ＂SMILE＂ National Cancer Specialist Palliative Care Training Class, jointly hosted by Cancer Rehabilitation and Palliative Care Committee, China （CRPC） and European Association for Palliative Care （EAPC）, supported by Xian-Janssen Pharmaceutical Ltd., was successfully held, including March 8th in Suzhou, March 22nd in Guangzhou, April 12th in Chengdu and April 26th in Wuhan. More than 200 medical staff all over the country took part in the class.
基金Supported by grants from the Key Project of Hubei Provincial Health Office (No. JX5A01)Wuhan Planning Project of Science and Technology (No. 201161038339-07)
文摘Objective： The aim of our study was to investigate if common toxicities are correlated to objective response rate （ORR） in metastatic colorectal cancer （mCRC） patients treated by irinotecan based regimens. Methods： Univadate and multivariate logistic regression analyses were performed to evaluate correlations between common toxicities and binary ORR in 106 mCRC patients from a prospective cohort treated with irinotecan based regimens. Results： The most frequent severe toxicities （Grade 3/4） were as follows： neutropenia （27.4%）, diarrhea （16.9%）, leucopenia （12.6%）, vomiting （3.2%） and thrombocytopenia （2.1%）. Thrombocytosis was observed in 25 （26.3%） patients. ORR was 25.3%. Thrombocytopenia （P = 0.014）, line of chemotherapy （P = 0.028） and thrembocytosis （P = 0.033） were correlated with ORR in univariate analysis. In multivariate analysis, thrombocytopenia （odds ratio [OR] = 8.600, 95% confidence interval [CI] = 1.705-43.385, P = 0.009） and first line chemotherapy （OR = 5.155, 95% CI = 1.153-23.256, P = 0.032） positively related to ORR. Conclusion： Threm- bocytopenia may be an indicator of ORR in mCRC patients treated by irinotecan plus 5-fluorouracil/capecitabine. Evidence is not strong enough to prove that irinotecan based regimens-induced diarrhea, leucopenia, neutropenia or vomiting is associ- ated with ORR.
文摘Objective: The purpose of the study was to survey current G-CSF use in cancer patients, investigate whether the use of granulocyte colony-stimulating factor(G-CSF) is standardized. Methods: From July 2012 to October 2012, patients in a third-grade class-A hospital were investigated by self-designed questionnaires, according to ASCO's recommendations for white blood cell growth factors in 2006 and NCCN myeloid growth factors guideline in 2012. Results: Two hundred and twenty-two patients treated with 724 courses of chemotherapy were included. In prophylactic use, 259(35.8%) cases used G-CSF that the guideline doesn't recommend, which belonged to excessive use, the dose were 274 700 μg, accounting for 59.7% of the totle prophylactic use; 105(14.5%) didn't use while the guideline recommend, belonging to lack of use. 89.0% of the prophylactic use were 24–72 h after chemotherapy, only a few(5.4%) on the day of chemotherapy. In therapeutic use, only 3.1% were standardized, with the dose of 23 000 μg, accounting for 7.4% of the total. So 92.6% were excessive. 14.2% of the therapeutic use were 24–72 h after chemotherapy, 21.2% on the day of chemotherapy. Conclusion: More than 50% use of G-CSF weren't standardized, especially the excessive use.
文摘Objective: The aim of the study was to investigate advanced medical students' knowledge towards cancer pain management, and understand the effect of specialisms and duration of oncology rotation on the advanced medical students' cognitive level towards cancer pain management. Methods: Randomly selected the respondents from a medical school in Wuhan, China. The educational background of the respondents should belong to one of these conditions: (1) clinical master degree candidate; (2) clinical doctor degree candidate; (3) the sixth or seventh year of clinical medicine for seven years. The respondents should also spend more than one year on internship. The self-developed questionnaire papers were distributed to respondents in the unit of dorms selected randomly and recovered them immediately after they're finished. The categori- cal data were expressed at the form of frequency (rate or constituent ratio). Chi-square test was required only as needed. Results: The survey was anonymous. We distributed 300 papers, recovered 300 papers and weeded out 8 invalid papers. Finally there were 292 valid papers, and the valid recovery rate was 97.3%. The 96.7% of oncological medical students and 47.6% non-oncological medical students relied on patients' description for cancer pain assessments; 90.0% of oncological medical students and 53.0% of non-oncological medical students prescribed strong opioid drugs firstly for patients suffering severe cancer pain; only 24.1% of non-oncological medical students recognized that pethidine was not safe and effective to treat cancer pain, which was much lower than oncological medical students (90.0%); 73.3% of oncological medical students and 28.9% of non-oncological medical students had the correct impression of drug addiction; 85.5% of non-oncological medi- cal students worried about the drug addiction, while 60.0% of oncological medical students worried about the strict control over opioid. In respect of the details of cancer pain management, only 66.7% of oncological medical students recognized that there was no upper limit of opioid prescribed clinically, and 16.3% of oncological medical students recognized that there was no psychological dependence if patients took opioid orally. The 69.8% of the students from no-less-than-two-week group relied on patients' description for cancer pain assessments, 76.7% prescribed strong opioid drugs firstly for patients suffer- ing severe cancer pain, 69.8% recognized that pethidine was not safe and effective to treat cancer pain, and 55.8% had the correct impression of drug addiction. All of the data were higher than that in no-rotation group and that in less-than-two-week group. The 51.2% of the students from no-less-than-two-week worried about drug addiction, which was the lowest of all. Conclusion: The cognitive level of advanced medical students towards cancer pain management is so low that it could not satisfy the clinical requirement, especially for the non-oncological medical students and the students spending little time on oncology rotation. Though the oncological medical students know something about cancer pain treatment, they know little about the details.
