A modified chitosan adsorbent was synthesized through a simple preparation procedure, and it demonstrated good adsorption performance for selective removal of low density lipoprotein in human plasma. Phase inversion ...A modified chitosan adsorbent was synthesized through a simple preparation procedure, and it demonstrated good adsorption performance for selective removal of low density lipoprotein in human plasma. Phase inversion technique was employed to form chitosan beads, to which epoxy groups were then introduced by reacting with ethyleneglycol diglycidylether, and tryptophan was subsequently coupled to the epoxy-activated beads.展开更多
Crosslinked macroporous polyacrylamide (PAM) was prepared with inverse phase suspension polymerization technique. After treatment with hydrazine, the polymer was functionalized with chloroacetic acid, trifluoroacetic ...Crosslinked macroporous polyacrylamide (PAM) was prepared with inverse phase suspension polymerization technique. After treatment with hydrazine, the polymer was functionalized with chloroacetic acid, trifluoroacetic acid diethylenetriaminepentaacetic acid (DEPAA), and maleic acid, respectively, and PAM based adsorbents bearing carboxyl functional groups for low density lipoprotein (LDL) apheresis use were obtained. The blood compatibility and the adsorption properties for plasma lipoproteins of PAM based adsorbents were investigated.展开更多
Macroporous poly (vinyl acetate-co-triallyl isocyanurate) beads were prepared with suspension polymerization method. The copolymer beads were then transformed into poly (vinyl alcohol-co-triallyl isocyanurate) by est...Macroporous poly (vinyl acetate-co-triallyl isocyanurate) beads were prepared with suspension polymerization method. The copolymer beads were then transformed into poly (vinyl alcohol-co-triallyl isocyanurate) by ester exchange reaction. Aminocarboxylic acids were immobilized on the copolymer beads by the esterification of hydroxyl groups with diethyl-lenetriaminepentaacetic bisanhydride. The weak acid exchange capacities, specific surface areas and mean pore diameters of the resultant resin beads were measured.展开更多
In the present work,the equilibrium adsorption of theophylline was studied by phenolic resin adsorbents: JDW\|2(made by ourselves) and Duolite S\|761 within a temperature range of 303\_323 K. The experimental results...In the present work,the equilibrium adsorption of theophylline was studied by phenolic resin adsorbents: JDW\|2(made by ourselves) and Duolite S\|761 within a temperature range of 303\_323 K. The experimental results show that the Freundlich adsorption law is applicable to the adsorption of theophylline on the two adsorbents,the exponents \%n\%>1 indicate that they are favorable to the adsorptions;the negative values of all the isosteric adsorption enthalpies for the theophylline indicate the exothermic process of the adsorption,while the range(10\_40 kJ/mol) of their magnitudes manifests the physisorption process;other thermodynamic properties,the free energy changes and the entropy change associated with adsorption have been calculated from the Gibbs adsorption equation and the Gibbs\|Helmholtz equation.展开更多
An adsorbent with good adsorption perform-ance for binding low density lipoprotein (LDL) was synthe-sized through a simple preparation procedure. The phase-inversion technique was employed to form macropor-ous chitosa...An adsorbent with good adsorption perform-ance for binding low density lipoprotein (LDL) was synthe-sized through a simple preparation procedure. The phase-inversion technique was employed to form macropor-ous chitosan beads, which were then simultaneously acti-vated, cross-linked and connected with a long spacer arm via the reaction with ethyleneglycol diglycidylether (EGDE). Tryptophan (Trp) was subsequently coupled to the ep-oxy-activated beads. This adsorbent demonstrated satisfac-tory adsorption capacity and selectivity for LDL, and it also exhibited excellent blood compatibility. The effect of spacer arms with different length on the adsorption selectivity was investigated experimentally, and the mechanism was ana-lyzed.展开更多
文摘A modified chitosan adsorbent was synthesized through a simple preparation procedure, and it demonstrated good adsorption performance for selective removal of low density lipoprotein in human plasma. Phase inversion technique was employed to form chitosan beads, to which epoxy groups were then introduced by reacting with ethyleneglycol diglycidylether, and tryptophan was subsequently coupled to the epoxy-activated beads.
文摘Crosslinked macroporous polyacrylamide (PAM) was prepared with inverse phase suspension polymerization technique. After treatment with hydrazine, the polymer was functionalized with chloroacetic acid, trifluoroacetic acid diethylenetriaminepentaacetic acid (DEPAA), and maleic acid, respectively, and PAM based adsorbents bearing carboxyl functional groups for low density lipoprotein (LDL) apheresis use were obtained. The blood compatibility and the adsorption properties for plasma lipoproteins of PAM based adsorbents were investigated.
基金This work was supported by the National 973 project (G1999064707)
文摘Macroporous poly (vinyl acetate-co-triallyl isocyanurate) beads were prepared with suspension polymerization method. The copolymer beads were then transformed into poly (vinyl alcohol-co-triallyl isocyanurate) by ester exchange reaction. Aminocarboxylic acids were immobilized on the copolymer beads by the esterification of hydroxyl groups with diethyl-lenetriaminepentaacetic bisanhydride. The weak acid exchange capacities, specific surface areas and mean pore diameters of the resultant resin beads were measured.
文摘In the present work,the equilibrium adsorption of theophylline was studied by phenolic resin adsorbents: JDW\|2(made by ourselves) and Duolite S\|761 within a temperature range of 303\_323 K. The experimental results show that the Freundlich adsorption law is applicable to the adsorption of theophylline on the two adsorbents,the exponents \%n\%>1 indicate that they are favorable to the adsorptions;the negative values of all the isosteric adsorption enthalpies for the theophylline indicate the exothermic process of the adsorption,while the range(10\_40 kJ/mol) of their magnitudes manifests the physisorption process;other thermodynamic properties,the free energy changes and the entropy change associated with adsorption have been calculated from the Gibbs adsorption equation and the Gibbs\|Helmholtz equation.
基金supported by the National Key Basic Research Development Project(Grant No.G1999064707)by Dazhan Group(Tianjin,China).
文摘An adsorbent with good adsorption perform-ance for binding low density lipoprotein (LDL) was synthe-sized through a simple preparation procedure. The phase-inversion technique was employed to form macropor-ous chitosan beads, which were then simultaneously acti-vated, cross-linked and connected with a long spacer arm via the reaction with ethyleneglycol diglycidylether (EGDE). Tryptophan (Trp) was subsequently coupled to the ep-oxy-activated beads. This adsorbent demonstrated satisfac-tory adsorption capacity and selectivity for LDL, and it also exhibited excellent blood compatibility. The effect of spacer arms with different length on the adsorption selectivity was investigated experimentally, and the mechanism was ana-lyzed.
